Def6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Def6	0.04	0.03	5.8e-03	0.01	0.01	0.01	0.01	6.7e-02	3.6e-02	1.5e-02	1.9e-02
2	PL	gene expression	Def6	0.02	0.02	2.7e-03	0.03	0.02	0.02	0.02	8.1e-04	5.4e-03	6.5e-03	1.3e-03
3	Liver	gene expression	Def6	0.15	0.07	2.1e-07	0.05	0.04	0.03	0.04	3.7e-06	8.5e-06	7.4e-04	1.1e-05
4	Adipose	gene expression	Def6	0.25	0.11	0.0e+00	0.17	0.16	0.19	0.1	2.0e-18	3.6e-17	2.0e-20	1.2e-11
5	pVTA	gene expression	Def6	0.08	0.05	4.8e-04	0	0.03	0.03	0.02	1.3e-01	1.4e-03	2.3e-03	5.7e-03
6	BLA	mRNA stability	Def6	0.06	0.04	7.5e-03	0.05	0.03	0.02	0.03	7.8e-04	1.3e-02	2.8e-02	7.7e-03
7	pVTA	mRNA stability	Def6	0.11	0.06	2.1e-05	0.05	0.05	0.04	0.04	1.0e-04	3.7e-05	5.5e-04	1.7e-04
8	PL	mRNA stability	Def6	0.05	0.03	2.9e-03	0	0.02	0.02	0.01	2.4e-01	2.1e-03	5.5e-03	1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.0	0.1	0.2	0.0	-0.1	0.1	0.3	0.3	-0.4	-0.1	-0.4
Area under the delay curve	0.3	0.4	1.5	-0.5	-0.0	0.3	-0.2	0.6	0.6	-1.2	-1.0
BMI with tail	1.8	6.5	11.1	3.2	3.0	3.3	2.8	-3.0	1.8	-0.2	-1.2
BMI without tail	0.6	3.2	5.1	2.2	2.1	2.3	1.4	-2.1	2.0	-0.4	-0.7
Body weight	1.2	5.2	19.5	0.1	1.9	2.6	1.5	-0.7	4.4	-2.3	-2.0
Weight adjusted by age	0.6	1.7	3.6	-1.9	-0.4	0.2	-0.3	1.6	1.0	-1.9	-1.6
Bone surface	0.1	0.3	0.8	-0.9	-0.6	-0.7	-0.0	0.7	0.4	0.0	0.2
Bone volume	0.0	0.1	0.3	-0.3	-0.1	-0.0	0.2	0.4	0.6	-0.3	-0.3
Breakpoint value in progressive ratio session	0.5	1.0	2.3	0.7	1.2	1.0	1.5	-1.1	0.4	1.1	0.2
Number of licking bursts	0.4	1.1	2.6	-0.8	-1.1	-1.2	-0.6	0.0	-0.9	1.3	1.6
Context. condit. distance diff. score	1.5	1.9	3.9	-1.7	-1.7	-2.0	-1.3	1.4	-0.8	0.5	1.0
Locomotion velocity, session 1	2.2	2.5	4.2	-1.8	-2.0	-1.9	-1.9	1.8	-1.4	-0.5	0.3
Locomotion distance, session 1	1.4	1.8	5.2	-0.3	-1.5	-1.8	-1.2	0.5	-2.3	0.9	1.2
Locomotion velocity, session 2	0.7	0.9	1.7	-0.9	-1.0	-1.3	-0.6	0.5	-0.8	0.9	1.1
Locomotion distance, session 2	0.4	0.6	1.4	-0.5	-1.0	-1.1	-0.6	0.8	-1.2	0.2	0.4
Locomotion velocity, session 3	0.5	0.6	1.5	0.7	-0.6	-0.9	-0.8	-0.7	-0.1	0.6	1.2
Locomotion distance, session 3	0.8	0.9	1.7	0.6	-1.0	-1.3	-1.2	-0.2	-1.0	0.5	1.2
Stereotopy head waving bouts, day 3	0.3	0.4	1.3	-1.0	-0.4	-0.4	-0.3	0.2	1.1	0.0	0.4
Stereotopy head waving duration, day 3	0.4	0.5	1.7	-1.3	-0.7	-0.6	-0.7	0.9	0.1	-0.3	-0.1
Locomotion velocity, session 7	0.7	0.8	1.3	-0.6	-0.7	-0.8	-1.1	1.1	-0.5	-1.1	-0.7
Locomotion distance, session 7	1.3	1.7	3.0	-0.9	-1.5	-1.4	-1.5	1.7	-1.2	-1.1	-0.5
Stereotopy head waving bouts, day 7	0.2	0.3	0.9	0.5	-0.3	-0.3	-0.9	-0.6	0.4	0.0	0.7
Stereotopy head waving duration, day 7	0.2	0.3	0.9	0.6	0.0	0.1	-0.5	-0.9	0.5	0.2	0.6
Locomotion velocity, session 8	2.2	2.7	6.4	-2.5	-1.9	-2.1	-1.6	1.9	-0.1	0.1	0.9
Locomotion distance, session 8	1.5	2.2	5.5	-1.3	-1.8	-2.3	-1.3	1.4	-1.2	0.7	1.3
Degree of sensitization distance	0.8	0.9	2.2	-1.5	0.0	0.2	0.6	1.4	0.5	-0.8	-1.2
Degree of sensitization stereotypy	0.4	0.5	0.9	0.8	-0.4	-0.5	-0.9	-0.7	-0.6	0.5	0.9
Conditioned locomotion	1.1	1.3	4.2	0.3	1.2	1.3	1.5	-0.5	2.0	-0.3	-0.6
Cocaine response after cond. corrected	0.6	0.9	1.7	0.9	1.1	0.8	1.3	-1.2	1.0	0.7	0.3
Cocaine response after cond. not corrected	0.2	0.3	0.8	0.1	0.5	0.1	0.5	-0.6	0.9	0.7	0.6
Cocaine response before conditioning	1.1	1.3	2.8	-1.7	-1.3	-1.3	-1.5	1.3	-0.1	-0.4	0.2
Saline control response	2.2	3.0	5.6	1.6	2.3	2.4	2.1	-1.2	1.3	-0.5	-1.6
Bone: connectivity density	0.1	0.2	0.5	-0.6	-0.2	0.0	0.2	0.7	-0.3	-0.4	-0.7
Bone: cortical apparent density	0.9	1.4	3.5	1.9	1.3	1.2	1.4	-1.5	0.5	0.6	-0.0
Bone: cortical area	0.0	0.1	0.2	-0.2	-0.3	-0.2	-0.5	0.1	-0.2	-0.1	0.2
Bone: cortical porosity	1.1	1.2	2.9	-0.8	-1.2	-1.0	-1.7	1.2	-0.8	-1.2	-0.4
Bone: cortical porosity	2.2	2.4	4.3	-1.7	-1.5	-1.0	-2.1	2.0	-0.7	-1.9	-1.0
Bone: cortical thickness	0.5	0.9	3.3	1.8	0.5	0.5	0.1	-1.3	-1.2	0.5	0.3
Bone: cortical thickness	1.9	2.3	5.0	2.2	1.8	1.7	2.0	-1.8	0.0	0.4	-0.4
Bone: cortical tissue density	0.8	1.2	2.8	1.7	1.2	1.1	1.3	-1.4	0.6	0.5	-0.0
Condit. Reinf. active minus inactive responses	0.8	0.9	2.3	-1.0	-0.6	-0.4	-0.6	1.5	-0.6	-1.2	-1.2
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.8	0.3	0.8	0.9	0.7	-0.1	0.3	-0.4	-0.9
Condit. Reinf. active responses	0.6	0.7	2.2	-0.6	-0.1	0.2	-0.1	1.1	-0.1	-1.4	-1.5
Condit. Reinf. inactive responses	0.2	0.2	0.8	0.2	0.1	0.3	0.3	0.3	-0.3	-0.7	-0.9
Incentive salience index mean	1.0	1.2	2.5	-1.5	-1.1	-0.9	-1.3	1.6	-0.5	-1.0	-0.6
Condit. Reinf. lever presses	0.7	1.1	2.4	-1.6	-1.2	-1.1	-1.4	1.2	-0.4	-0.4	0.1
Condit. Reinf. active minus inactive responses	0.6	0.9	1.7	-1.3	-0.9	-1.0	-1.1	1.3	-0.6	-0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.5	1.0	-1.0	-0.5	-0.7	-0.9	1.0	-0.1	-0.4	-0.1
Condit. Reinf. active responses	0.6	0.8	1.5	-1.2	-1.0	-1.0	-1.0	1.2	-0.9	-0.3	-0.0
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	-0.2	-0.0	0.2	-0.0	-0.2	0.1	0.0
Condit. Reinf. lever presses	1.4	2.0	4.8	-1.4	-1.3	-1.2	-1.6	1.8	-2.2	-0.4	-0.3
Condit. Reinf. lever reinforcers received	1.0	1.4	2.1	-1.4	-1.3	-1.3	-1.4	1.5	-1.3	-0.3	0.0
Conditioned reinforcement - actives	0.1	0.4	1.1	-0.5	-0.8	0.4	-0.4	0.5	0.0	-1.0	-0.6
Conditioned reinforcement - inactives	0.1	0.3	0.8	-0.3	-0.8	-0.4	-0.9	0.4	-0.6	-0.7	-0.2
Conditioned locomotion	1.1	1.7	5.4	-1.3	-0.3	0.5	-0.4	1.3	0.9	-2.3	-1.8
Patch foraging indifference point 0 sec	0.5	1.3	2.6	1.6	1.0	1.6	1.3	-1.3	0.7	-0.2	-0.5
Patch foraging indifference point AUC	0.5	1.1	2.4	-1.1	-1.1	-1.5	-1.3	0.7	-0.5	0.7	1.2
Delay disc. indifference point, 0s delay	0.1	0.2	0.4	-0.6	-0.4	-0.2	-0.1	0.6	0.1	-0.4	-0.3
Delay disc. indifference point, 16s delay	0.2	0.2	0.9	0.0	-0.6	0.1	-0.1	0.4	0.4	-1.0	-0.6
Delay disc. indifference point, 2s delay	0.8	0.9	2.3	-1.5	-0.5	-0.3	-0.7	1.4	-0.4	-1.0	-0.9
Delay disc. indifference point, 24s delay	0.7	1.1	4.6	-0.2	0.1	0.6	-0.1	0.7	0.8	-2.2	-1.7
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.2	0.5	0.3	0.1	0.0	0.7	-0.5	-0.5
Delay disc. indifference point, 8s delay	0.5	0.8	2.4	-0.6	0.2	0.6	-0.2	0.6	0.8	-1.6	-1.3
Indifference point function ln k	0.1	0.4	0.9	-0.3	-1.0	-0.6	-0.5	0.3	-0.8	0.3	0.5
Indifference point function log k	0.1	0.4	0.9	-0.3	-1.0	-0.6	-0.5	0.3	-0.8	0.3	0.5
Patch foraging total patch changes 0 sec	0.4	1.3	2.9	1.7	1.0	1.6	1.2	-1.3	0.5	-0.2	-0.5
Patch foraging total patch changes 12 sec	0.3	0.4	1.0	0.9	0.0	0.2	0.1	-1.0	-0.5	0.9	0.8
Patch foraging total patch changes 18 sec	0.9	2.0	5.1	2.3	1.5	1.5	1.4	-2.0	0.8	0.4	0.0
Patch foraging total patch changes 24 sec	0.2	0.8	2.8	1.7	0.9	0.9	0.8	-0.9	-0.2	0.0	-0.4
Patch foraging total patch changes 6 sec	0.7	1.2	3.3	1.8	1.2	1.1	1.2	-1.2	0.3	-0.1	-0.5
Patch foraging time to switch 0 sec	1.0	3.8	7.5	2.0	2.6	2.4	2.7	-1.9	1.3	-0.0	-1.1
Patch foraging water rate 0 sec	0.1	0.3	1.0	-0.4	-0.9	-0.3	-1.0	0.6	-0.2	-0.4	0.1
Patch foraging water rate 12 sec	0.1	0.4	1.2	1.1	-0.3	-0.4	-0.4	-0.7	-0.6	0.5	0.8
Patch foraging water rate 18 sec	0.1	0.3	0.8	-0.0	0.4	0.8	0.1	0.3	0.5	-0.7	-0.9
Patch foraging water rate 24 sec	0.4	0.6	1.4	1.0	-0.3	-0.3	-0.3	-0.8	-0.5	1.0	1.2
Patch foraging water rate 6 sec	0.2	0.3	1.0	0.7	-0.3	-0.6	-0.1	-0.4	-0.3	0.8	1.0
Seeking ratio, delayed vs. immediate footshock	0.7	1.0	2.6	1.1	0.7	-0.0	0.3	-1.3	0.2	1.6	1.4
Distance traveled before self-admin	0.4	0.8	1.5	0.9	0.6	0.1	0.3	-1.2	1.2	1.1	1.2
Distance traveled after self-admin	0.4	0.8	1.6	0.5	0.7	0.5	0.7	-1.0	1.1	1.2	0.9
Extensor digitorum longus weight	0.5	2.2	5.7	-2.4	-1.9	-1.5	-1.3	1.7	-1.0	0.3	0.6
Bone: elastic displacement	0.6	0.7	2.1	-0.1	-0.8	-0.4	-1.4	0.7	-0.5	-1.3	-0.7
Bone: elastic work	0.3	0.4	1.6	0.1	-0.1	0.3	-0.6	0.5	0.1	-1.3	-1.1
Bone: endosteal estimation	0.8	2.0	9.2	-2.0	0.4	0.4	0.6	1.0	3.0	-0.9	-0.7
Bone: endosteal perimeter	0.3	0.7	3.4	-1.4	0.2	-0.0	0.2	0.5	1.8	-0.1	0.0
Epididymis fat weight	4.1	20.9	51.7	7.2	5.4	5.1	4.8	-5.7	1.4	0.3	-1.5
Delta time in closed arm before/after self-admin	0.8	0.7	1.3	0.8	0.9	1.2	0.5	-0.5	0.7	-1.1	-1.0
Delta time in open arm before/after self-admin	0.1	0.1	0.5	-0.7	-0.3	-0.3	-0.1	0.4	-0.1	0.4	0.3
Diff in mean of infusions in LGA sessions	0.2	0.3	0.6	0.6	0.7	0.3	0.8	-0.5	-0.4	0.7	0.1
Delay discount exponential model param	0.3	0.4	1.5	0.5	0.1	-0.2	0.3	-0.6	-0.5	1.2	1.0
Extinction: sum of active levers before priming	0.1	0.2	0.4	0.4	0.0	-0.2	0.3	-0.4	-0.0	0.6	0.6
Active lever presses in extinction session 6	1.2	1.2	3.9	-0.2	0.5	1.1	0.6	0.7	0.5	-1.8	-2.0
Bone: final force	2.5	4.1	6.3	2.1	2.5	2.5	2.4	-1.9	2.4	-0.4	-1.0
Bone: final moment	1.8	2.9	4.6	1.7	2.0	2.2	1.9	-1.4	2.1	-0.7	-1.1
Food consumed during 24 hour testing period	0.8	1.7	4.7	0.2	1.6	1.6	2.2	-0.5	1.6	-0.0	-0.9
Glucose	3.1	4.9	11.3	-3.4	-2.6	-2.1	-2.7	2.7	-0.8	-1.0	0.0
Heart weight	2.1	3.4	5.3	-2.2	-2.2	-1.1	-2.2	2.3	-1.8	-1.5	-0.9
Delay discount hyperbolic model param	0.3	0.4	1.2	0.7	0.3	0.1	0.6	-0.8	-0.1	1.1	0.8
Intermittent access intake day 1-15 change	0.2	1.0	1.8	1.2	1.3	0.9	0.9	-1.3	0.7	0.8	0.3
Intermittent access intake escalation	0.2	1.2	2.5	1.3	1.6	1.2	1.2	-1.4	0.8	0.5	-0.1
Intermittent access intake escalation 2	0.0	0.1	0.2	-0.5	0.1	0.2	-0.3	0.2	0.1	-0.1	-0.1
Intermitt. access day 1 inactive lever presses	0.2	2.7	7.0	0.6	-1.0	-1.4	-0.8	-0.8	-1.9	2.7	2.6
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.4	0.2	-0.2	-0.0	-0.0	-0.4	0.2	0.4	0.7
Intermitt. access escalation Index	0.6	1.7	5.4	1.0	-0.0	-0.9	-0.2	-1.1	-1.2	2.3	2.0
Intermittent access day 1 total infusions	1.0	2.9	5.4	-2.2	-2.3	-0.5	-1.4	2.2	-1.0	-1.9	-1.2
Intermittent access day 15 total infusions	0.1	0.2	0.6	-0.4	-0.4	0.3	-0.2	0.4	-0.3	-0.8	-0.7
Intermittent access terminal intake (last 3 days)	0.2	0.4	1.1	-0.5	-0.6	0.1	-0.5	0.6	-0.3	-1.1	-0.8
Intermittent access total infusions	0.9	1.1	1.8	-1.2	-1.3	-0.1	-0.8	1.3	-0.5	-1.4	-1.0
Intermittent access day 1 locomotion	0.2	0.3	0.7	-0.6	-0.7	-0.1	-0.5	0.6	0.2	-0.8	-0.5
Intermittent access day 15 total locomotion	0.4	1.7	5.8	0.1	1.0	1.4	0.6	-0.2	2.4	-1.6	-1.3
Intermittent access total locomotion	0.7	0.8	2.4	-0.7	-0.1	0.6	-0.1	0.7	1.3	-1.5	-1.2
Intermittent access standard deviation	0.3	1.7	2.7	1.6	1.5	1.6	1.6	-1.5	1.2	0.3	-0.2
Left kidney weight	0.3	2.7	10.5	0.7	1.3	2.0	1.4	-1.1	3.2	-1.1	-0.8
Right kidney weight	0.6	4.5	17.7	0.6	2.0	2.3	2.0	-1.2	4.2	-1.3	-1.2
Cocaine induced anxiety	0.2	0.5	1.8	-0.1	-0.3	-0.7	-0.1	-0.2	-0.1	1.3	1.3
Post-drug Anxiety	0.2	0.2	0.7	0.1	0.5	-0.2	0.6	-0.2	0.5	0.8	0.4
Baseline Anxiety	0.7	1.3	2.3	1.1	1.5	1.3	1.5	-0.7	0.7	-0.5	-1.1
Tail length	0.5	2.9	7.6	-2.7	-1.3	-1.4	-1.7	1.8	2.2	-1.0	0.2
Length with tail	1.2	5.2	13.9	-3.7	-1.3	-0.7	-1.4	2.6	3.3	-2.4	-1.0
Length without tail	0.6	3.3	9.6	-1.9	0.3	1.1	0.4	1.3	3.1	-2.5	-2.0
Times rat made contact with spout	0.2	0.3	1.6	0.6	0.2	0.2	0.2	-0.1	-1.3	0.1	-0.3
Lifetime Intake	0.8	0.9	2.3	-1.1	-1.0	0.1	-0.6	1.1	-0.2	-1.5	-1.1
Liver weight, left	0.4	0.7	3.8	-1.1	0.3	0.2	0.3	0.3	2.0	-0.1	-0.0
Liver weight, right	1.1	1.9	6.3	-2.0	-1.0	-1.2	-0.7	1.1	2.5	-0.1	0.9
Locomotor activity	0.6	0.9	3.2	0.4	-0.2	-0.5	0.0	-1.1	0.1	1.6	1.8
Locomotor testing distance	0.5	1.3	3.0	1.2	0.7	0.3	0.9	-1.7	-0.1	1.7	1.3
Locomotor testing rearing	0.4	1.5	2.5	1.1	1.4	0.9	1.5	-1.6	1.2	1.1	0.7
Locomotion in novel chamber	0.2	0.3	1.1	-0.5	-0.7	-0.1	-0.6	0.2	-1.0	0.1	0.2
Locomotion in novel chamber post-restriction	0.7	2.0	3.7	1.2	1.8	1.6	1.4	-1.0	1.9	-0.7	-1.0
Fecal boli incidents, locomotor time 1	0.3	0.8	2.0	-0.5	0.4	1.1	0.8	0.5	0.7	-1.1	-1.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.4	0.6	0.1	0.1	-0.7	-0.0	0.4	0.3
Time >=10cm from walls, locomotor time 1	2.0	2.5	5.7	1.4	2.4	2.0	1.8	-1.8	1.1	1.0	0.1
Bouts of movement, locomotor time 1	0.3	0.4	1.5	0.1	-0.0	-0.3	-0.0	-0.4	-0.0	1.2	1.0
Total resting periods, locomotor time 1	0.2	0.2	0.7	-0.2	-0.1	-0.3	-0.1	-0.1	0.3	0.8	0.7
Rest time, locomotor task time 1	0.5	0.9	1.9	-0.9	-1.1	-1.1	-1.4	1.1	-0.1	-0.6	0.1
Distance moved, locomotor task time 1	0.3	0.8	1.5	0.8	1.2	1.1	1.2	-1.0	0.9	0.3	-0.2
Vertical activity count, locomotor time 1	0.5	3.1	7.1	1.0	2.3	2.3	2.7	-1.4	1.8	0.3	-0.9
Time >=10cm from walls, locomotor time 2	1.0	2.8	5.3	0.5	2.3	2.3	1.7	-0.7	1.4	-1.4	-2.1
Bouts of movement, locomotor time 2	0.1	0.4	0.8	-0.3	0.3	-0.7	-0.2	-0.0	0.7	0.9	0.9
Total resting periods, locomotor time 2	0.2	0.7	1.7	-0.6	-0.2	-1.3	-0.7	0.3	0.3	1.1	1.3
Rest time, locomotor task time 2	0.5	0.8	2.4	-0.2	-0.6	-1.1	-0.8	-0.0	-0.1	1.2	1.5
Distance moved, locomotor task time 2	2.5	3.3	6.4	0.4	1.8	2.3	1.7	-0.3	2.0	-2.1	-2.5
Vertical activity count, locomotor time 2	1.3	3.1	6.4	-0.2	1.5	2.0	1.9	0.2	2.2	-1.9	-2.5
Light reinforcement 1	0.9	4.3	7.3	2.3	2.3	1.9	2.7	-2.7	1.8	1.5	0.7
Light reinforcement 2	1.1	2.4	5.5	1.0	1.9	1.5	2.3	-1.2	2.3	0.3	-0.4
Bone: marrow area	0.9	2.1	9.7	-1.9	0.6	0.5	0.7	0.9	3.1	-1.0	-0.8
Bone: maximum diameter	0.8	1.6	4.8	-2.2	-1.3	-1.4	-1.3	1.5	0.3	-0.2	0.4
Bone: maximum force	0.4	0.8	1.8	0.7	0.9	1.1	0.9	-0.5	1.4	-0.6	-0.6
Bone: maximum moment	0.3	0.5	1.2	0.1	0.5	0.8	0.4	0.1	1.1	-1.0	-0.9
Mean time between licks in bursts	0.9	5.1	9.2	-3.0	-2.8	-3.0	-1.9	2.0	-1.4	1.1	2.0
Mean num. licks in bursts	0.3	0.8	2.2	1.0	1.0	0.9	0.4	0.0	-0.1	-1.0	-1.5
Cd content in liver	1.5	1.7	4.8	0.0	1.1	1.5	1.2	0.5	0.9	-1.6	-2.2
Co content in liver	3.0	3.5	6.8	1.5	2.4	2.6	2.1	-1.2	1.5	-1.2	-2.0
Cu content in liver	0.7	0.8	3.0	1.2	0.5	0.2	0.4	-0.8	-1.7	0.8	0.3
Fe content in liver	0.5	0.7	1.7	0.9	0.7	0.7	1.0	-0.7	1.3	-0.4	-0.2
K content in liver	1.6	1.5	2.6	-1.2	-1.6	-1.6	-1.5	1.2	-1.3	-0.0	0.6
Mg content in liver	2.1	2.3	4.2	-1.9	-1.8	-2.1	-1.5	1.4	-1.4	0.7	1.1
Mn content in liver	2.5	2.8	5.7	-2.4	-2.2	-2.3	-1.3	1.8	-0.2	0.4	1.2
Na content in liver	0.5	0.6	1.4	0.8	-0.2	-0.5	-0.5	-0.8	-0.7	1.0	1.2
Rb content in liver	0.3	0.4	1.1	-0.6	0.5	0.5	0.2	0.6	0.1	-0.7	-1.1
Se content in liver	4.5	5.3	9.9	-2.8	-2.9	-3.1	-2.5	2.4	-1.6	0.5	1.5
Sr content in liver	0.8	0.7	2.1	-0.5	0.2	0.7	0.2	0.8	0.6	-1.4	-1.4
Zn content in liver	1.4	1.7	3.8	-2.0	-1.4	-1.3	-1.3	1.8	-1.0	-0.4	-0.0
Bone: minimum diameter	0.3	0.6	2.1	-1.5	-0.1	0.0	-0.2	0.7	1.2	-0.5	-0.3
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.7	0.1	0.2	-0.2	-0.0	-0.4	-0.6	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.3	-0.2	-0.3	-0.1	-0.1	0.3	0.2	0.3
Total zone transitions, hab. session 1	1.6	2.2	5.7	0.3	-1.4	-1.6	-1.2	-0.3	-2.4	1.5	1.9
Total locomotion distance, hab. session 1	1.7	2.4	4.9	-0.1	-1.7	-2.0	-1.3	0.0	-2.2	1.4	1.9
Locomotion velocity, hab. session 1	1.6	2.3	4.5	-0.3	-1.7	-1.9	-1.4	0.2	-2.1	1.3	1.9
Time in familiar zone, hab. session 2	1.3	1.5	5.3	0.6	0.2	-0.4	0.9	-1.1	-0.8	2.3	1.8
Time in novel zone, hab. session 2	1.9	2.1	7.0	-0.7	0.2	0.8	-0.6	1.1	1.0	-2.6	-2.4
Total zone transitions, hab. session 2	1.3	1.7	4.8	1.0	-0.3	-0.9	0.0	-1.3	-0.8	2.0	2.2
Total locomotion distance, hab. session 2	2.3	3.0	8.4	0.7	-0.9	-1.6	-0.4	-1.1	-1.8	2.7	2.9
Locomotion velocity, hab. session 2	2.6	3.5	9.5	0.5	-1.3	-1.9	-0.7	-0.9	-2.0	2.8	3.1
Novel to familiar place preference ratio	0.1	0.2	0.7	0.4	0.0	0.4	-0.1	0.1	0.1	-0.9	-0.6
Novelty place preference	0.1	0.1	0.6	0.2	-0.1	0.2	-0.2	0.2	0.1	-0.8	-0.5
Time in novel zone, NPP test	0.1	0.2	0.8	0.1	0.0	0.2	-0.2	0.3	0.2	-0.9	-0.7
Total zone transitions, NPP test	1.1	1.6	3.6	-0.3	-1.3	-1.9	-1.1	0.4	-1.7	1.0	1.5
Total locomotion distance, NPP test	0.3	0.4	1.6	0.1	-0.6	-0.9	-0.5	0.4	-1.3	0.3	0.4
Locomotion velocity, NPP test	0.5	0.7	2.5	0.4	-0.6	-1.0	-0.4	0.0	-1.6	0.8	0.9
Intraocular pressure	0.1	0.2	0.5	0.1	0.3	0.4	0.3	-0.2	0.7	-0.6	-0.3
Delta distance traveled before/after self-admin	0.3	0.3	0.8	-0.8	-0.0	0.6	0.3	0.7	-0.2	-0.5	-0.9
Delta ambulatory time before/after self-admin	0.1	0.2	0.5	-0.7	0.1	0.5	0.5	0.4	-0.0	-0.1	-0.6
Parametrial fat weight	2.6	6.1	8.8	2.5	2.8	3.0	2.8	-3.0	2.9	0.5	-0.3
Pavlov. Cond. lever latency	4.4	5.6	11.9	2.5	3.0	2.8	3.4	-2.4	1.7	0.8	-0.7
Pavlov. Cond. magazine entry latency	3.5	4.4	7.9	-2.5	-2.5	-2.8	-2.8	2.2	-1.3	-0.2	0.9
Pavlov. Cond. change in total contacts	1.3	1.4	3.9	-1.2	-1.4	-1.2	-2.0	1.1	-0.3	-0.9	0.0
Pavlov. Cond. index score	4.3	5.4	11.1	-2.6	-2.9	-2.9	-3.3	2.4	-1.4	-0.7	0.7
Pavlov. Cond. latency score	4.0	5.1	10.2	-2.5	-2.9	-2.8	-3.2	2.3	-1.3	-0.6	0.8
Pavlov. Cond. lever contacts	3.3	3.9	8.9	-2.2	-2.5	-2.2	-3.0	2.1	-1.2	-0.9	0.4
Pavlov. Cond. magazine entry number	2.9	3.7	6.5	2.1	2.3	2.6	2.5	-1.9	1.6	-0.1	-1.0
Pavlov. Cond. intertrial magazine entries	1.3	1.5	3.6	1.0	1.2	1.5	1.2	-0.1	0.6	-1.5	-1.9
Pavlov. Cond. lever-magazine prob. diff.	4.2	5.3	11.4	-2.4	-2.9	-2.8	-3.4	2.4	-1.4	-0.8	0.7
Pavlov. Cond. response bias	4.5	5.6	10.8	-2.6	-2.9	-3.0	-3.3	2.4	-1.7	-0.3	1.0
Pavlov. Cond. lever latency	1.0	1.4	2.9	0.9	1.0	0.9	1.5	-1.5	1.7	0.8	0.7
Pavlov. Cond. magazine entry latency	0.6	0.8	1.8	-1.1	0.0	0.1	-0.3	1.2	0.9	-1.3	-1.2
Pavlov. Cond. change in total contacts	0.2	0.6	1.3	-0.7	-0.5	-0.4	-0.8	1.1	-0.9	-0.7	-0.7
Pavlov. Cond. index score	0.7	1.1	2.4	-1.2	-0.7	-0.6	-1.2	1.6	-0.5	-1.2	-0.9
Pavlov. Cond. latency score	0.5	0.8	1.8	-1.1	-0.5	-0.5	-1.1	1.3	-0.4	-1.0	-0.8
Pavlov. Cond. lever contacts	0.7	1.0	2.4	-0.7	-0.7	-0.6	-1.3	1.3	-1.5	-0.9	-0.7
Pavlov. Cond. magazine entry number	0.3	0.5	1.2	0.4	-0.5	-0.5	0.0	-0.6	-0.5	1.0	1.1
Pavlov. Cond. intertrial magazine entries	0.9	2.0	5.1	-1.0	-1.0	-1.6	-0.2	-0.0	-1.0	2.3	2.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.9	2.0	-1.1	-0.5	-0.4	-1.1	1.4	-0.4	-1.2	-1.0
Pavlov. Cond. response bias	1.2	1.6	3.3	-1.3	-0.9	-0.9	-1.6	1.8	-1.0	-1.4	-1.0
Time in closed arm before self-admin	0.1	0.1	0.3	-0.5	-0.1	-0.1	-0.3	0.5	-0.5	-0.2	-0.3
Time in closed arm after self-admin	0.5	0.5	1.6	-0.1	-0.1	0.3	-0.6	0.5	-0.9	-1.3	-1.0
Time in open arm before self-admin	0.4	0.4	0.8	-0.6	-0.8	-0.8	-0.8	0.6	-0.9	-0.2	0.3
Time in open arm after self-admin	0.4	0.4	0.9	-0.9	-0.8	-0.8	-0.4	0.7	-0.1	0.5	0.6
Bone: periosteal estimation	0.3	0.7	3.4	-1.2	0.2	0.1	0.2	0.5	1.9	-0.4	-0.2
Bone: periosteal perimeter	0.1	0.2	0.6	-0.8	0.1	0.1	-0.1	0.2	0.7	-0.0	0.1
Bone: post-yield work	0.5	0.9	3.5	-1.9	-0.4	-0.1	-0.3	1.3	0.8	-0.9	-0.6
Progressive ratio test 1 active lever presses	0.4	0.6	2.0	-0.7	-0.5	0.4	-0.3	0.8	-0.1	-1.4	-1.2
Progressive ratio test 1 breakpoint	0.4	0.7	1.9	-0.8	-0.7	0.2	-0.4	0.9	-0.3	-1.4	-1.1
Progressive ratio test 1 inactive lever presses	0.3	0.7	1.6	1.3	0.8	1.1	0.9	-1.2	0.4	-0.0	-0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.1	-0.3	0.0	-0.3	0.2	-0.2	-0.6	-0.4
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	-0.2	-0.4	0.0	-0.3	0.3	-0.3	-0.6	-0.4
Progressive ratio test 2 inactive lever presses	0.3	1.0	1.9	-1.2	-1.1	-0.6	-1.4	1.1	-0.7	-1.0	-0.3
Incentive Sensitization - Responses	0.2	0.7	1.3	0.0	-0.9	-0.8	-0.7	-0.1	-1.1	1.0	1.1
Incentive Sensitization - Breakpoint	0.2	0.5	1.2	0.2	-0.7	-0.6	-0.5	-0.3	-0.9	1.0	1.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	-0.6	-0.2	-0.4	0.5	-0.4	-0.3	-0.2
Progressive ratio	1.2	3.5	5.8	2.2	2.3	1.8	2.2	-2.1	2.4	0.3	-0.3
Food seeking constrained by brief footshock	0.5	0.7	2.3	0.1	0.3	0.9	0.2	0.5	0.4	-1.4	-1.5
Seeking ratio, punishment vs. effort	1.0	2.2	3.8	-1.4	-1.8	-1.3	-1.8	1.7	-2.0	-0.7	-0.1
Retroperitoneal fat weight	0.3	1.2	3.2	1.1	1.3	1.0	0.9	-1.2	1.8	-0.3	-0.2
Reaction time number correct	0.8	2.9	6.4	2.5	2.2	1.6	2.0	-1.9	1.2	0.3	-0.3
Reaction time mean minus median	0.3	2.2	8.1	-2.8	-1.5	-1.4	-1.2	1.9	0.5	-0.5	0.2
Reaction time mean minus median AUC	0.5	3.1	9.5	-3.1	-1.4	-1.0	-1.4	2.5	0.6	-1.6	-0.9
Reaction time num false alarms	0.7	1.2	3.0	-0.6	-1.4	-1.1	-0.9	0.0	-0.7	1.3	1.7
Reaction time num false alarms AUC	0.8	1.9	3.9	-0.8	-1.7	-1.6	-1.3	0.3	-1.2	1.5	2.0
Reaction time trials correct on left	0.8	2.9	6.4	2.5	2.2	1.6	2.0	-1.9	1.2	0.3	-0.3
Reaction time trials on left	0.8	2.8	6.0	2.4	2.1	1.6	2.0	-1.9	1.3	0.3	-0.3
Reaction time mean	0.8	1.7	6.7	-2.6	-0.6	-0.3	-0.5	1.9	0.6	-1.2	-0.9
Reaction time mean AUC	0.7	1.8	5.9	-2.4	-0.3	-0.1	-0.3	1.8	1.0	-1.5	-1.2
Median of all reaction times	0.7	1.1	3.5	-1.9	-0.1	0.2	-0.1	1.4	0.6	-1.3	-1.2
Reaction time omissions	0.2	0.4	1.3	-1.1	-0.3	-0.6	-0.2	0.2	0.4	0.7	0.8
Reaction time false alarm rate	3.1	4.3	7.9	-2.2	-2.8	-2.4	-2.4	1.4	-1.8	1.1	1.9
Reaction time premature initiation rate	0.0	0.0	0.2	-0.0	-0.1	0.2	0.3	-0.2	-0.4	0.2	-0.0
Reaction time premature initiations	0.4	1.2	2.5	1.4	1.3	1.3	1.6	-1.3	0.5	0.2	-0.4
Std. dev. reaction times	1.0	3.3	12.0	-3.5	-1.6	-1.4	-1.5	2.5	0.3	-1.0	-0.3
Reaction time trials completed	0.8	2.8	6.0	2.4	2.1	1.6	2.0	-1.9	1.3	0.3	-0.3
Reaction time trials AUC	0.8	2.9	6.1	2.5	2.2	1.6	2.1	-1.9	1.3	0.3	-0.3
Run reversals in cocaine runway, females	0.9	1.0	3.2	-0.4	-0.1	0.7	0.1	0.8	0.4	-1.8	-1.7
Run reversals in cocaine runway, males	1.5	1.6	3.4	-1.8	-1.5	-1.3	-1.8	1.4	0.0	-0.6	0.3
Latency to leave start box in cocaine runway	0.4	0.6	3.2	-0.2	-0.5	-0.5	-0.9	0.3	-1.8	0.3	0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	1.1	-0.2	-0.4	-0.3	-0.3	0.3	-1.0	0.2	0.1
Latency to leave start box in cocaine runway, M	0.4	0.3	1.8	0.1	-0.1	-0.3	-0.8	-0.2	-1.3	0.2	0.3
Std. dev. time between licks in bursts	1.9	3.6	7.6	-2.1	-2.4	-2.8	-2.0	1.2	-0.6	0.9	2.1
Total sessions with >9 infusions	0.4	0.5	0.8	-0.9	-0.9	-0.0	-0.5	0.8	-0.4	-0.9	-0.6
Short access day 1 total inactive lever presses	0.7	1.4	3.4	-1.9	-1.1	-0.5	-1.3	1.6	-0.1	-1.4	-0.8
Short access day 10 total inactive lever presses	0.6	3.9	11.4	2.0	0.4	-0.7	0.2	-2.2	-0.9	3.4	3.0
Short access day 1 total infusions	0.6	1.3	2.6	-1.6	-1.6	-0.4	-1.0	1.4	-0.7	-1.1	-0.6
Short access day 10 total infusions	0.1	0.1	0.3	-0.2	-0.6	0.3	0.1	0.2	-0.2	-0.2	-0.2
Short access total infusions	0.5	0.8	1.7	-1.1	-0.9	0.3	-0.4	1.0	-0.2	-1.3	-1.0
Short access day 1 locomotion	0.3	0.5	1.2	0.2	-0.7	-0.7	-0.3	-0.3	-0.7	1.0	1.1
Short access day 10 total locomotion	0.1	0.5	1.9	0.1	-0.4	-0.6	-0.3	-0.3	0.0	1.3	1.4
Short access total locomotion	0.0	0.1	0.2	-0.0	-0.2	-0.1	-0.0	-0.1	0.1	0.4	0.4
One hour access (0.3 mA shock)	1.5	1.8	4.0	-0.6	-1.6	-1.5	-1.4	0.6	-2.0	1.0	1.2
Compulsive drug intake	0.9	1.3	4.6	-0.3	-0.7	-0.9	0.0	0.1	-1.2	2.2	1.6
One hour access (shock baseline)	0.4	1.0	2.2	-1.1	-0.9	-0.4	-1.2	1.1	-0.2	-1.5	-0.9
Social response proportion	0.1	0.1	0.6	-0.8	-0.4	-0.2	-0.0	0.6	-0.1	-0.0	-0.0
Social responses	0.2	0.3	1.1	-0.0	-0.0	-0.3	0.3	-0.4	-0.2	1.1	0.9
Social time	1.7	2.6	8.1	-0.9	-1.1	-1.6	-0.3	-0.3	-0.5	2.8	2.8
Soleus weight	2.1	6.3	17.5	-4.2	-2.8	-2.6	-2.9	2.9	0.6	-0.6	0.8
Bone: stiffness	0.7	1.2	2.9	1.2	1.3	1.1	1.7	-1.2	1.1	0.3	-0.1
Tibialis anterior weight	0.1	0.5	1.9	-0.0	-0.4	-0.2	0.3	-0.1	-1.4	1.1	0.6
Time to tail flick, vehicle, before self-admin	2.0	2.5	5.1	1.8	1.2	-0.0	0.7	-2.2	0.9	2.2	2.0
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.6	-0.8	-0.2	-0.3	-0.2	0.5	-0.6	0.3	0.0
Time to tail flick, test, before self-admin	1.0	1.2	3.0	1.2	0.0	-0.6	-0.4	-1.2	-0.7	1.6	1.7
Time to tail flick, test, after self-admin	0.5	0.6	1.7	-0.4	-0.6	-1.2	-1.3	0.3	-0.6	0.3	0.7
Delta time to tail flick, vehicle, before/after SA	1.8	1.9	4.1	-1.4	-0.8	0.2	-0.4	1.9	-0.9	-1.9	-2.0
Delta time to tail flick, test, before/after SA	0.1	0.2	0.5	0.1	0.4	0.4	0.4	0.0	0.4	-0.5	-0.7
Tibia length	0.4	1.2	7.7	-0.7	0.8	0.4	0.8	-0.3	2.8	0.0	0.2
Ambulatory time before self-admin	0.2	0.5	1.1	0.7	0.2	-0.1	0.1	-0.9	0.9	0.9	1.1
Ambulatory time after self-admin	0.3	0.4	0.9	0.2	0.4	0.4	0.6	-0.6	0.9	0.9	0.6
Bone: tissue strength	0.5	0.5	1.2	0.4	0.6	1.0	0.1	0.0	0.6	-1.0	-1.1
Total heroin consumption	0.6	0.8	3.1	0.5	0.2	-0.1	0.6	-0.8	0.1	1.8	1.3
Bone: trabecular number	0.1	0.1	0.8	-0.0	-0.3	-0.0	0.2	0.4	-0.9	-0.1	-0.4
Bone: trabecular spacing	0.4	0.6	2.3	0.2	0.9	0.9	0.4	-0.4	1.5	-0.4	-0.4
Bone: trabecular thickness	0.2	0.3	0.7	0.0	0.3	0.4	0.6	0.2	0.8	-0.8	-0.8
Bone: trabecular tissue density	0.4	0.7	1.5	-0.9	-1.1	-0.9	-1.2	1.0	0.1	-0.6	0.1
Water consumed over 24 hours	0.1	0.1	0.5	-0.5	-0.0	-0.2	-0.2	0.1	-0.7	0.5	0.1
Number of responses in last shaping day	2.8	3.6	5.7	-2.3	-2.4	-1.5	-2.2	2.3	-1.8	-1.3	-0.4