Def6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Def6	0.05	0.03	3.9e-03	0.01	0.02	0.02	0.02	2.1e-02	1.2e-02	6.7e-03	8.9e-03
2	Adipose	gene expression	Def6	0.21	0.09	0.0e+00	0.15	0.13	0.16	0.09	4.7e-16	1.1e-14	6.0e-18	7.8e-10
3	LHb	mRNA stability	Def6	0.25	0.14	3.6e-03	0.07	0.05	0.04	0.14	9.8e-03	3.0e-02	4.2e-02	3.0e-04
4	Liver	gene expression	Def6	0.15	0.07	2.5e-07	0.05	0.04	0.04	0.04	3.2e-06	1.3e-05	9.1e-06	8.7e-06
5	BLA	mRNA stability	Def6	0.06	0.04	3.9e-03	0.05	0.04	0.03	0.04	9.7e-04	5.1e-03	8.9e-03	3.1e-03
6	pVTA	gene expression	Def6	0.14	0.09	2.6e-03	0.04	0.05	0.05	0.05	6.0e-03	3.0e-03	3.4e-03	3.1e-03
7	pVTA	mRNA stability	Def6	0.12	0.08	8.2e-03	-0	0.02	0.01	-0	3.7e-01	4.1e-02	8.7e-02	6.3e-01
8	PL	mRNA stability	Def6	0.04	0.03	3.1e-03	0	0.01	-0	0.01	2.2e-01	4.4e-02	6.8e-01	7.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.1	0.7	0.2	0.3	0.3	-0.0	-0.9	0.3	0.2	-0.2
Area under the delay curve	0.5	0.6	1.7	-0.4	-0.2	0.4	0.2	0.6	1.0	-1.3	-1.0
BMI with tail	1.4	4.6	8.8	2.4	2.6	-2.6	3.0	2.1	-1.1	-1.2	-1.3
BMI without tail	0.5	1.0	2.6	1.0	0.4	-1.1	0.8	1.6	-1.3	0.1	0.5
Body weight	1.9	8.2	26.1	-1.5	1.1	-1.9	2.5	5.1	1.0	-4.2	-2.7
Weight adjusted by age	1.6	1.8	4.0	-1.8	-0.3	-0.1	0.4	1.3	1.7	-2.0	-1.6
Bone surface	0.2	0.3	1.1	-1.1	-0.6	0.6	-0.7	-0.0	0.3	-0.0	0.2
Bone volume	0.0	0.1	0.2	-0.5	-0.1	0.2	-0.2	0.1	0.3	-0.3	-0.1
Breakpoint value in progressive ratio session	0.6	0.6	1.6	0.6	1.3	-0.7	0.9	-0.2	-0.9	0.9	0.1
Number of licking bursts	1.0	1.2	2.2	-0.8	-1.0	1.2	-1.1	-1.0	-0.6	1.3	1.5
Context. condit. distance diff. score	1.8	2.2	4.2	-1.9	-2.0	1.8	-2.0	-0.8	0.6	0.5	1.0
Locomotion velocity, session 1	1.9	2.0	4.0	-1.4	-1.9	2.0	-1.9	-1.3	1.3	-0.2	0.3
Locomotion distance, session 1	1.5	1.9	5.0	0.6	-1.1	1.5	-1.7	-2.2	-0.0	1.4	1.2
Locomotion velocity, session 2	0.8	1.0	1.6	-1.0	-1.1	1.0	-1.3	-1.1	-0.2	0.9	1.1
Locomotion distance, session 2	0.4	0.5	1.2	-0.3	-0.7	1.0	-1.1	-1.0	0.5	0.4	0.4
Locomotion velocity, session 3	0.5	0.6	1.4	0.5	-1.0	0.4	-0.9	0.2	-0.9	0.3	1.2
Locomotion distance, session 3	0.9	1.0	1.7	0.7	-1.3	1.0	-1.3	-1.1	-0.4	0.7	1.2
Stereotopy head waving bouts, day 3	0.7	0.8	2.7	-1.6	-0.9	0.4	-0.5	1.5	-0.0	-0.6	0.3
Stereotopy head waving duration, day 3	0.5	0.6	2.1	-1.5	-1.0	0.7	-0.7	0.4	0.8	-0.5	-0.2
Locomotion velocity, session 7	0.5	0.5	1.4	-0.1	-0.9	0.5	-0.8	-0.1	1.2	-1.0	-0.7
Locomotion distance, session 7	1.0	1.2	2.7	-0.6	-1.3	1.3	-1.5	-0.9	1.6	-0.6	-0.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.3	-0.7	0.3	-0.4	0.3	-0.5	-0.1	0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.6	0.5	-0.3	-0.3	0.2	0.8	-0.8	-0.2	0.4
Locomotion velocity, session 8	2.6	3.1	8.7	-3.0	-2.4	2.0	-2.1	-0.2	1.0	-0.1	0.7
Locomotion distance, session 8	1.6	2.4	5.4	-1.5	-2.1	1.9	-2.3	-1.1	0.5	0.8	1.3
Degree of sensitization distance	0.8	0.8	2.2	-1.5	0.2	-0.2	0.1	0.6	1.3	-0.9	-1.2
Degree of sensitization stereotypy	0.4	0.4	0.9	1.0	-0.6	0.2	-0.4	-0.5	-0.8	0.5	0.9
Conditioned locomotion	1.1	1.3	4.4	-0.9	0.9	-1.2	1.2	2.1	-0.3	-0.9	-0.6
Cocaine response after cond. corrected	0.7	0.7	1.2	0.7	1.0	-1.1	0.8	1.1	-1.1	0.4	0.3
Cocaine response after cond. not corrected	0.3	0.4	1.6	-0.1	0.0	-0.5	0.1	1.3	-0.8	0.3	0.6
Cocaine response before conditioning	1.1	1.3	3.1	-1.8	-1.7	1.1	-1.3	0.3	1.0	-0.5	0.1
Saline control response	2.8	3.7	7.5	2.1	2.7	-2.6	2.5	1.6	-0.8	-0.4	-1.2
Bone: connectivity density	0.1	0.2	0.5	-0.3	0.2	0.4	-0.1	-0.7	0.7	-0.0	-0.4
Bone: cortical apparent density	0.8	1.1	2.7	1.6	1.3	-1.3	1.2	0.7	-0.8	0.2	-0.2
Bone: cortical area	0.0	0.0	0.1	0.1	-0.2	0.0	-0.0	0.2	-0.0	-0.2	0.1
Bone: cortical porosity	1.1	1.2	2.9	-0.8	-1.1	1.4	-0.9	-0.3	1.7	-1.4	-0.8
Bone: cortical porosity	1.9	2.1	4.9	-1.5	-1.4	1.6	-1.0	-0.2	2.2	-1.6	-1.1
Bone: cortical thickness	0.8	1.4	7.1	2.7	1.1	-0.7	0.8	-0.7	-0.8	0.5	0.1
Bone: cortical thickness	2.2	2.5	6.9	2.6	2.2	-1.7	1.6	-0.0	-1.4	0.7	-0.1
Bone: cortical tissue density	0.7	0.9	1.9	1.4	1.1	-1.3	1.2	0.8	-0.7	0.1	-0.2
Condit. Reinf. active minus inactive responses	0.8	0.9	2.8	-0.7	-0.4	0.7	-0.4	-1.1	1.7	-0.8	-1.1
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.9	0.4	0.9	-0.7	0.9	-0.2	0.3	-0.2	-0.9
Condit. Reinf. active responses	0.5	0.7	2.0	-0.2	0.1	0.1	0.2	-0.4	1.4	-1.0	-1.4
Condit. Reinf. inactive responses	0.2	0.2	0.6	0.6	0.5	-0.2	0.4	-0.2	0.6	-0.5	-0.8
Incentive salience index mean	0.9	1.1	2.3	-1.3	-1.1	1.1	-0.9	-0.9	1.5	-0.7	-0.6
Condit. Reinf. lever presses	0.7	0.9	1.8	-1.3	-1.3	1.2	-1.1	-0.6	0.9	-0.3	0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.5	-1.2	-1.0	0.9	-1.1	-0.8	1.1	-0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.2	-1.1	-0.9	0.6	-0.8	-0.1	0.9	-0.3	-0.2
Condit. Reinf. active responses	0.6	0.8	1.4	-1.1	-0.8	1.0	-1.1	-1.2	0.9	0.0	0.0
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	0.2	0.1	-0.0	-0.2	-0.1	0.0	0.1
Condit. Reinf. lever presses	1.0	1.3	4.5	-0.6	-0.9	1.3	-1.1	-2.1	1.4	0.4	-0.2
Condit. Reinf. lever reinforcers received	0.9	1.3	3.1	-1.1	-1.1	1.4	-1.4	-1.8	1.1	0.2	0.1
Conditioned reinforcement - actives	0.8	0.8	1.9	-1.1	-0.5	0.7	-0.0	0.7	1.2	-1.4	-0.9
Conditioned reinforcement - inactives	0.1	0.1	0.3	-0.3	-0.6	0.1	-0.3	-0.1	0.4	-0.2	0.0
Conditioned locomotion	2.4	2.9	6.7	-1.9	-0.6	0.4	0.2	1.0	2.6	-2.6	-2.1
Patch foraging indifference point 0 sec	0.9	1.5	3.1	1.6	1.8	-1.4	1.7	0.9	-0.8	-0.2	-0.4
Patch foraging indifference point AUC	1.1	1.2	3.2	-1.3	-1.8	1.0	-1.5	-0.6	0.0	0.4	1.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.4	-0.2	0.4	-0.2	-0.1	0.6	-0.4	-0.3
Delay disc. indifference point, 16s delay	0.3	0.4	0.8	0.0	-0.2	0.9	0.0	0.7	0.7	-0.8	-0.6
Delay disc. indifference point, 2s delay	0.7	0.7	2.1	-1.2	-0.5	0.7	-0.4	-0.5	1.4	-0.7	-0.9
Delay disc. indifference point, 24s delay	1.7	1.7	5.2	-0.2	0.2	0.1	0.7	1.6	1.4	-2.3	-1.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.2	0.1	-0.5	0.4	0.7	0.2	-0.7	-0.5
Delay disc. indifference point, 8s delay	1.0	1.0	3.1	-0.6	-0.1	-0.1	0.5	0.9	1.2	-1.8	-1.4
Indifference point function ln k	0.2	0.3	0.8	-0.3	-0.5	0.9	-0.7	-0.5	-0.0	0.4	0.6
Indifference point function log k	0.2	0.3	0.8	-0.3	-0.5	0.9	-0.7	-0.5	-0.0	0.4	0.6
Patch foraging total patch changes 0 sec	1.0	1.6	3.2	1.8	1.7	-1.4	1.6	0.9	-0.8	-0.2	-0.4
Patch foraging total patch changes 12 sec	0.4	0.5	1.3	1.1	0.4	-0.5	0.4	-0.3	-1.1	0.8	0.8
Patch foraging total patch changes 18 sec	1.8	2.3	5.1	2.3	1.8	-2.1	1.6	1.0	-1.5	0.2	-0.0
Patch foraging total patch changes 24 sec	0.9	1.1	4.2	2.0	1.3	-1.0	1.0	-0.4	-0.6	0.5	-0.2
Patch foraging total patch changes 6 sec	1.0	1.4	4.3	2.1	1.4	-1.5	1.3	0.4	-0.8	0.1	-0.3
Patch foraging time to switch 0 sec	2.7	4.2	9.3	2.2	3.0	-2.7	2.5	1.6	-1.3	-0.1	-1.0
Patch foraging water rate 0 sec	0.3	0.4	1.0	-0.7	-1.0	0.9	-0.5	-0.5	0.7	-0.3	0.1
Patch foraging water rate 12 sec	0.3	0.4	1.0	1.0	-0.4	0.1	-0.5	-0.6	-0.7	0.7	0.9
Patch foraging water rate 18 sec	0.2	0.2	0.6	0.1	0.3	0.1	0.7	0.0	0.7	-0.4	-0.8
Patch foraging water rate 24 sec	0.4	0.6	1.4	0.8	-0.4	0.2	-0.4	-0.4	-0.9	1.1	1.2
Patch foraging water rate 6 sec	0.3	0.4	0.9	0.3	-0.6	0.6	-0.7	-0.4	-0.4	0.7	0.9
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	2.7	0.8	0.2	-0.7	-0.1	0.3	-1.7	1.3	1.4
Distance traveled before self-admin	0.9	0.9	2.9	0.2	-0.0	-0.9	0.0	1.1	-1.7	0.9	1.3
Distance traveled after self-admin	1.0	1.1	3.2	0.3	0.5	-1.2	0.5	0.9	-1.8	1.2	1.2
Extensor digitorum longus weight	0.5	1.9	6.0	-2.5	-1.5	1.7	-1.4	-0.8	0.8	0.4	0.6
Bone: elastic displacement	0.4	0.5	1.2	0.3	-0.6	0.6	-0.5	-0.3	1.1	-0.9	-0.7
Bone: elastic work	0.3	0.4	1.1	0.4	0.1	-0.1	0.3	-0.0	0.9	-1.0	-1.0
Bone: endosteal estimation	1.2	2.7	8.5	-2.9	-0.1	-0.6	0.6	2.6	0.8	-1.9	-1.0
Bone: endosteal perimeter	0.6	1.2	4.7	-2.2	-0.5	-0.4	0.1	1.9	0.0	-0.8	-0.1
Epididymis fat weight	4.7	10.9	28.5	5.3	4.1	-4.2	3.7	1.7	-1.4	-1.2	-2.0
Delta time in closed arm before/after self-admin	0.6	0.6	1.4	0.2	0.5	-1.0	0.8	1.2	-0.0	-0.9	-0.6
Delta time in open arm before/after self-admin	0.2	0.2	0.8	-0.3	0.1	0.4	-0.1	-0.9	0.4	0.4	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.5	0.4	-0.1	0.2	-0.5	-0.0	0.5	-0.1
Delay discount exponential model param	0.5	0.6	1.7	0.4	0.3	-0.5	-0.0	-0.6	-1.0	1.3	0.9
Extinction: sum of active levers before priming	0.1	0.1	0.4	0.2	0.1	0.3	-0.1	-0.3	-0.4	0.6	0.4
Active lever presses in extinction session 6	2.0	1.9	5.0	0.1	1.3	-0.9	1.5	0.8	1.5	-1.6	-2.2
Bone: final force	2.9	4.6	8.1	1.5	2.8	-2.8	2.8	2.5	-0.9	-1.3	-1.4
Bone: final moment	2.1	3.4	5.9	1.1	2.3	-2.4	2.4	2.2	-0.4	-1.5	-1.5
Food consumed during 24 hour testing period	0.8	1.0	2.3	-0.3	1.5	-1.4	1.4	0.8	-0.2	-0.3	-0.8
Glucose	3.8	5.7	13.8	-3.7	-3.2	2.8	-2.6	-0.7	2.3	-1.0	0.1
Heart weight	1.6	2.3	4.1	-1.1	-1.9	2.0	-2.0	-1.5	1.7	-0.0	0.0
Delay discount hyperbolic model param	0.4	0.5	1.2	0.5	0.4	-0.5	0.1	-0.3	-1.0	1.1	0.8
Intermittent access intake day 1-15 change	0.7	0.7	2.0	1.1	0.5	-0.8	0.4	0.8	-1.4	0.5	0.7
Intermittent access intake escalation	0.6	0.5	1.6	0.6	0.3	-0.8	0.4	1.0	-1.3	0.3	0.6
Intermittent access intake escalation 2	0.9	0.9	2.0	-1.4	-1.4	1.2	-0.9	-0.3	0.1	0.3	0.7
Intermitt. access day 1 inactive lever presses	2.0	2.1	5.2	1.1	-0.3	0.4	-0.9	-0.3	-2.1	2.1	2.3
Intermitt. access day 15 inactive lever presses	0.6	0.6	2.4	0.4	0.3	-0.6	0.2	1.5	-1.2	0.2	0.7
Intermitt. access escalation Index	1.4	1.2	2.9	1.1	-0.0	0.0	-0.5	-0.9	-1.5	1.7	1.5
Intermittent access day 1 total infusions	1.3	1.5	4.5	-1.5	-0.8	1.2	-0.3	-0.3	2.1	-1.3	-1.3
Intermittent access day 15 total infusions	0.1	0.1	0.3	-0.1	0.0	0.1	0.2	0.5	0.3	-0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.4	0.4	1.0	-0.7	-0.4	0.4	0.1	0.6	0.9	-1.0	-0.7
Intermittent access total infusions	0.8	0.9	2.4	-1.1	-0.4	0.7	0.1	0.2	1.6	-1.1	-1.1
Intermittent access day 1 locomotion	0.4	0.4	0.8	-0.8	-0.4	-0.1	-0.1	0.8	0.8	-0.9	-0.5
Intermittent access day 15 total locomotion	2.1	2.2	7.3	-0.9	0.2	-1.4	1.0	2.7	0.6	-2.1	-1.3
Intermittent access total locomotion	1.7	2.0	4.4	-1.4	-0.0	-0.9	0.8	2.0	1.3	-2.1	-1.5
Intermittent access standard deviation	1.2	1.3	2.2	1.2	1.5	-1.3	1.4	1.2	-1.3	0.3	0.1
Left kidney weight	1.0	2.7	11.0	-1.2	0.3	-1.0	1.0	3.3	0.5	-2.3	-1.2
Right kidney weight	0.9	2.5	12.8	-1.4	0.1	-1.1	0.7	3.6	-0.1	-1.8	-0.5
Cocaine induced anxiety	1.3	1.6	3.9	0.6	-0.2	-0.2	-0.6	-0.2	-2.0	2.0	2.0
Post-drug Anxiety	0.8	0.8	2.4	0.6	-0.0	-0.5	-0.3	-0.5	-1.3	1.6	1.2
Baseline Anxiety	0.6	0.6	1.7	0.6	0.7	-0.4	0.7	-0.3	0.9	-0.7	-1.3
Tail length	1.9	5.8	19.1	-4.4	-3.2	2.0	-2.1	2.3	1.2	-1.3	0.6
Length with tail	1.9	7.0	20.4	-4.5	-2.0	1.2	-0.8	3.3	2.3	-3.3	-1.3
Length without tail	1.7	3.7	9.1	-2.4	0.2	0.0	0.8	2.3	2.1	-3.0	-2.2
Times rat made contact with spout	0.5	0.6	2.3	1.3	0.6	0.0	0.1	-1.5	0.1	0.8	-0.2
Lifetime Intake	0.9	1.1	2.7	-1.1	-0.3	0.5	0.2	0.5	1.6	-1.5	-1.4
Liver weight, left	1.3	2.0	7.8	-2.1	-0.4	-0.8	0.2	2.8	0.2	-1.8	-0.5
Liver weight, right	3.1	5.1	18.3	-4.3	-2.7	1.6	-2.3	2.1	0.5	-0.9	1.2
Locomotor activity	0.6	1.0	3.1	0.2	-0.2	-0.1	-0.4	0.2	-1.7	1.3	1.8
Locomotor testing distance	1.1	1.9	5.0	1.6	0.7	-0.7	0.2	-0.4	-2.2	1.8	1.7
Locomotor testing rearing	0.8	1.3	2.8	0.9	1.1	-1.5	0.8	1.4	-1.7	0.6	0.7
Locomotion in novel chamber	0.3	0.4	1.8	-0.5	-0.4	0.8	-0.2	-1.3	0.5	0.2	0.1
Locomotion in novel chamber post-restriction	1.2	1.5	2.5	0.9	1.3	-1.4	1.5	1.6	-0.2	-1.1	-1.0
Fecal boli incidents, locomotor time 1	0.5	0.6	1.6	-0.3	0.6	-0.3	0.8	0.3	1.0	-0.8	-1.3
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.1	-0.3	-0.5	-0.4	-0.6	-0.5	0.4	0.5
Time >=10cm from walls, locomotor time 1	2.0	2.0	4.9	0.7	1.8	-2.2	1.9	1.0	-1.6	0.4	0.0
Bouts of movement, locomotor time 1	0.4	0.5	1.2	-0.1	-0.6	-0.3	-0.6	-0.4	-0.7	1.1	1.1
Total resting periods, locomotor time 1	0.2	0.3	0.5	-0.5	-0.7	-0.3	-0.6	-0.0	-0.3	0.6	0.7
Rest time, locomotor task time 1	0.6	0.7	1.7	-1.2	-1.3	0.6	-1.1	0.0	0.8	-0.6	-0.0
Distance moved, locomotor task time 1	0.8	0.9	2.0	1.2	1.4	-1.0	1.3	0.4	-0.8	0.2	-0.2
Vertical activity count, locomotor time 1	2.6	2.8	6.8	1.2	2.6	-2.1	2.6	0.9	-1.0	0.0	-0.9
Time >=10cm from walls, locomotor time 2	3.2	3.4	6.1	0.4	2.1	-2.3	2.5	1.8	0.2	-1.9	-2.1
Bouts of movement, locomotor time 2	0.4	0.4	0.6	-0.8	-0.7	-0.5	-0.6	0.5	-0.6	0.4	0.8
Total resting periods, locomotor time 2	0.8	0.8	1.6	-1.1	-1.2	0.0	-1.2	-0.1	-0.4	0.8	1.2
Rest time, locomotor task time 2	0.8	0.9	2.1	-0.9	-1.3	0.4	-1.2	-0.2	-0.6	0.9	1.4
Distance moved, locomotor task time 2	2.9	3.4	6.0	0.8	1.9	-1.7	2.3	1.8	0.9	-2.2	-2.4
Vertical activity count, locomotor time 2	2.9	3.1	6.2	0.2	1.8	-1.5	2.2	1.7	1.1	-2.0	-2.5
Light reinforcement 1	2.0	3.7	7.0	1.9	2.2	-2.5	2.0	1.7	-2.6	0.7	0.7
Light reinforcement 2	1.1	1.5	2.9	0.2	1.5	-1.7	1.5	1.7	-1.1	-0.3	-0.3
Bone: marrow area	1.2	2.7	8.1	-2.8	-0.0	-0.7	0.7	2.7	0.7	-1.9	-1.1
Bone: maximum diameter	0.9	1.7	6.0	-2.5	-1.8	1.1	-1.3	0.7	0.8	-0.6	0.3
Bone: maximum force	0.7	1.2	1.8	0.4	1.3	-1.2	1.4	1.3	0.0	-1.2	-1.0
Bone: maximum moment	0.5	0.9	1.9	-0.0	0.8	-0.8	1.0	1.0	0.5	-1.4	-1.2
Mean time between licks in bursts	3.8	5.3	11.5	-3.4	-2.9	2.7	-2.9	-1.2	0.3	1.1	2.1
Mean num. licks in bursts	0.7	0.9	2.1	1.5	1.0	-0.9	0.8	-0.1	0.5	-0.6	-1.3
Cd content in liver	2.4	2.6	4.8	1.2	1.6	-1.5	2.1	1.3	0.7	-1.8	-2.2
Co content in liver	3.2	3.7	6.6	2.3	2.5	-2.5	2.6	1.3	-1.0	-0.8	-1.2
Cu content in liver	0.8	1.0	4.0	1.7	0.4	0.1	-0.1	-2.0	0.0	0.9	0.1
Fe content in liver	1.1	1.3	4.6	-0.3	0.4	-0.4	0.6	2.1	0.4	-2.0	-0.9
K content in liver	2.3	2.3	4.4	-1.8	-1.8	2.1	-2.0	-1.4	0.8	0.4	0.8
Mg content in liver	5.7	5.9	10.4	-2.9	-3.0	3.2	-3.1	-2.3	1.6	0.5	1.0
Mn content in liver	3.2	3.6	11.3	-3.4	-2.3	2.1	-2.4	-0.5	1.1	0.1	0.9
Na content in liver	0.2	0.2	0.5	0.1	-0.7	0.1	-0.5	0.2	-0.4	0.3	0.6
Rb content in liver	0.5	0.6	1.6	-0.8	0.0	-0.1	0.3	0.1	1.2	-1.2	-1.3
Se content in liver	7.9	9.6	17.4	-3.7	-4.1	4.1	-4.2	-2.3	1.5	0.8	1.8
Sr content in liver	0.6	0.6	1.9	-0.1	0.5	-0.4	0.8	0.0	1.0	-0.9	-1.4
Zn content in liver	1.2	1.3	2.7	-1.6	-1.0	1.1	-0.6	0.2	1.6	-1.4	-0.8
Bone: minimum diameter	0.5	0.9	3.5	-1.9	-0.4	0.1	0.1	1.2	0.6	-1.1	-0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.6	0.8	0.3	-0.1	0.1	-0.3	0.3	-0.4	-0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.3	-0.5	-0.1	-0.3	0.3	-0.2	-0.0	0.3
Total zone transitions, hab. session 1	1.9	2.6	6.2	1.0	-1.0	1.5	-1.5	-2.5	-0.9	1.9	1.9
Total locomotion distance, hab. session 1	1.8	2.6	4.5	0.4	-1.4	1.8	-1.9	-2.1	-0.7	1.8	2.0
Locomotion velocity, hab. session 1	1.8	2.6	4.4	0.1	-1.4	2.0	-1.9	-2.1	-0.5	1.6	1.9
Time in familiar zone, hab. session 2	1.5	1.6	5.2	0.6	0.2	-0.1	-0.3	-0.5	-1.8	2.3	1.9
Time in novel zone, hab. session 2	2.2	2.2	6.5	-0.4	0.2	-0.2	0.8	0.6	2.0	-2.6	-2.4
Total zone transitions, hab. session 2	1.4	1.9	4.7	1.1	-0.5	0.4	-0.9	-0.8	-1.8	2.0	2.2
Total locomotion distance, hab. session 2	2.8	3.7	8.5	0.9	-0.9	1.2	-1.5	-1.8	-2.0	2.9	2.9
Locomotion velocity, hab. session 2	3.2	4.3	9.6	0.7	-1.3	1.6	-1.9	-2.0	-1.9	3.0	3.1
Novel to familiar place preference ratio	0.2	0.2	0.7	0.3	0.3	0.1	0.3	-0.0	0.5	-0.8	-0.6
Novelty place preference	0.2	0.2	0.6	0.1	0.1	0.2	0.1	0.0	0.5	-0.8	-0.5
Time in novel zone, NPP test	0.2	0.2	0.8	0.0	0.0	0.1	0.1	0.2	0.6	-0.9	-0.7
Total zone transitions, NPP test	1.2	1.8	3.2	0.2	-1.3	1.5	-1.8	-1.7	-0.2	1.4	1.4
Total locomotion distance, NPP test	0.4	0.5	1.7	0.5	-0.4	0.8	-0.8	-1.3	0.2	0.7	0.4
Locomotion velocity, NPP test	0.7	0.9	2.6	0.9	-0.3	0.8	-0.9	-1.6	-0.3	1.3	0.9
Intraocular pressure	0.2	0.3	1.3	-0.2	0.2	-0.3	0.3	1.1	0.0	-0.8	-0.4
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.3	0.5	-0.0	0.4	-0.4	0.5	-0.0	-0.6
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.2	0.4	-0.1	0.3	-0.4	0.1	0.4	-0.2
Parametrial fat weight	1.0	2.0	3.9	1.2	1.3	-2.0	1.6	1.7	-1.8	-0.1	0.3
Pavlov. Cond. lever latency	3.8	4.8	9.7	2.2	3.1	-3.1	2.8	1.8	-1.6	0.3	-0.7
Pavlov. Cond. magazine entry latency	3.3	4.2	8.7	-2.4	-2.9	2.6	-2.7	-1.5	1.5	-0.0	0.7
Pavlov. Cond. change in total contacts	1.2	1.2	3.1	-1.3	-1.7	1.3	-1.3	-0.4	1.0	-1.0	-0.1
Pavlov. Cond. index score	4.0	5.1	10.4	-2.6	-3.2	3.0	-2.9	-1.5	1.8	-0.5	0.5
Pavlov. Cond. latency score	3.8	4.8	9.7	-2.6	-3.1	2.9	-2.8	-1.4	1.7	-0.5	0.6
Pavlov. Cond. lever contacts	3.3	3.8	7.5	-2.0	-2.7	2.7	-2.4	-1.4	1.9	-0.7	0.1
Pavlov. Cond. magazine entry number	2.6	3.2	6.7	1.8	2.6	-2.3	2.5	1.6	-1.0	-0.4	-1.0
Pavlov. Cond. intertrial magazine entries	1.4	1.6	3.1	1.3	1.6	-1.2	1.5	0.4	0.7	-1.1	-1.8
Pavlov. Cond. lever-magazine prob. diff.	4.0	5.0	10.1	-2.5	-3.2	3.0	-2.8	-1.5	1.9	-0.6	0.4
Pavlov. Cond. response bias	4.5	5.5	11.1	-2.6	-3.3	3.1	-3.0	-1.8	2.0	-0.2	0.6
Pavlov. Cond. lever latency	0.9	1.2	2.4	0.7	1.0	-1.5	1.1	1.5	-1.6	0.1	0.4
Pavlov. Cond. magazine entry latency	1.0	1.1	2.3	-1.3	-0.2	-0.1	0.1	0.7	1.5	-1.5	-1.4
Pavlov. Cond. change in total contacts	0.4	0.5	1.4	-0.3	-0.3	0.7	-0.5	-1.1	1.2	-0.1	-0.6
Pavlov. Cond. index score	0.6	0.8	2.6	-1.0	-0.7	0.8	-0.6	-0.5	1.6	-0.8	-0.9
Pavlov. Cond. latency score	0.5	0.7	2.0	-1.0	-0.6	0.7	-0.5	-0.4	1.4	-0.8	-0.8
Pavlov. Cond. lever contacts	0.4	0.5	1.6	0.2	-0.2	0.7	-0.4	-1.3	1.1	-0.1	-0.6
Pavlov. Cond. magazine entry number	0.4	0.5	1.3	0.4	-0.3	0.4	-0.4	-0.4	-0.9	1.0	1.1
Pavlov. Cond. intertrial magazine entries	1.7	2.3	4.8	-1.2	-1.4	1.0	-1.6	-1.1	-1.2	2.0	2.2
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	2.4	-0.9	-0.5	0.5	-0.3	-0.2	1.5	-0.9	-1.0
Pavlov. Cond. response bias	0.7	1.0	3.1	-0.6	-0.7	0.9	-0.7	-0.9	1.8	-0.8	-1.0
Time in closed arm before self-admin	0.1	0.1	0.4	-0.2	0.1	0.3	0.1	-0.4	0.6	-0.2	-0.5
Time in closed arm after self-admin	0.3	0.3	0.9	0.1	0.1	-0.1	0.4	0.2	0.7	-1.0	-0.9
Time in open arm before self-admin	0.7	0.8	1.6	-1.1	-1.3	1.2	-1.1	-0.5	0.6	0.0	0.4
Time in open arm after self-admin	0.8	0.9	1.8	-1.2	-1.0	1.3	-1.1	-0.9	0.9	0.5	0.2
Bone: periosteal estimation	0.5	1.0	3.3	-1.6	-0.1	-0.5	0.4	1.8	0.2	-1.2	-0.5
Bone: periosteal perimeter	0.2	0.3	1.0	-0.9	-0.1	-0.4	0.3	1.0	-0.2	-0.3	0.0
Bone: post-yield work	0.5	0.7	2.3	-1.5	-0.2	0.4	0.1	0.4	1.1	-1.0	-0.8
Progressive ratio test 1 active lever presses	1.1	1.1	3.3	-1.1	-0.5	0.0	0.0	0.3	1.8	-1.5	-1.4
Progressive ratio test 1 breakpoint	0.8	0.9	2.6	-0.8	-0.4	0.0	0.0	0.3	1.6	-1.3	-1.3
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.4	1.0	1.0	-1.2	1.0	1.2	-0.7	-0.3	-0.3
Progressive ratio test 2 active lever presses	0.1	0.1	0.2	0.0	0.1	-0.5	0.2	0.2	0.3	-0.4	-0.4
Progressive ratio test 2 breakpoint	0.0	0.0	0.2	0.3	0.0	-0.4	0.1	0.0	0.1	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.8	0.9	2.3	-1.5	-1.2	0.8	-0.7	-0.2	1.2	-0.8	-0.4
Incentive Sensitization - Responses	1.0	1.0	2.6	0.6	-0.2	0.1	-0.4	-1.0	-1.2	1.6	1.4
Incentive Sensitization - Breakpoint	1.0	1.0	2.5	0.8	-0.0	-0.2	-0.3	-0.8	-1.5	1.6	1.5
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.8	-0.9	-0.5	1.2	-0.3	-0.6	1.3	-0.6	-0.8
Progressive ratio	2.8	3.2	7.5	1.4	2.0	-2.7	1.9	2.3	-1.7	-0.3	-0.2
Food seeking constrained by brief footshock	0.4	0.5	1.3	0.4	0.6	-0.3	1.0	0.3	0.7	-0.7	-1.1
Seeking ratio, punishment vs. effort	1.4	1.7	4.6	-0.6	-1.4	2.1	-1.2	-1.7	1.3	0.2	0.0
Retroperitoneal fat weight	0.6	1.8	3.9	0.4	0.8	-1.7	1.2	2.0	0.3	-1.9	-1.4
Reaction time number correct	1.6	2.3	5.5	2.3	1.7	-2.0	1.5	1.1	-1.6	0.2	0.0
Reaction time mean minus median	2.2	2.9	11.7	-3.4	-1.8	1.8	-1.4	0.4	1.3	-0.8	0.1
Reaction time mean minus median AUC	2.8	3.7	12.8	-3.6	-1.6	1.9	-1.1	0.3	2.3	-1.7	-1.0
Reaction time num false alarms	0.8	1.0	2.6	-1.0	-1.0	0.9	-1.0	-0.4	-0.8	1.1	1.6
Reaction time num false alarms AUC	1.3	1.8	4.0	-1.0	-1.3	1.3	-1.4	-0.9	-0.8	1.6	2.0
Reaction time trials correct on left	1.6	2.3	5.5	2.3	1.7	-2.0	1.5	1.1	-1.6	0.2	0.0
Reaction time trials on left	1.5	2.2	5.0	2.2	1.7	-2.0	1.5	1.1	-1.5	0.2	-0.0
Reaction time mean	1.3	1.9	7.6	-2.8	-0.7	1.3	-0.3	0.1	1.6	-1.2	-1.0
Reaction time mean AUC	1.4	1.9	7.0	-2.7	-0.5	1.0	-0.1	0.4	1.7	-1.5	-1.3
Median of all reaction times	0.6	0.8	3.0	-1.7	-0.1	0.6	0.2	0.1	1.1	-0.9	-1.0
Reaction time omissions	0.4	0.5	2.1	-1.5	-0.8	0.6	-0.6	-0.2	-0.1	0.2	0.6
Reaction time false alarm rate	2.5	3.5	5.8	-2.3	-2.3	2.4	-2.2	-1.5	0.3	1.2	1.7
Reaction time premature initiation rate	0.1	0.1	0.4	0.1	0.5	0.1	0.2	-0.6	-0.2	0.4	0.0
Reaction time premature initiations	0.8	1.1	2.7	1.4	1.6	-1.2	1.2	0.2	-1.0	0.3	-0.2
Std. dev. reaction times	2.6	3.6	14.7	-3.8	-1.8	2.1	-1.3	0.1	1.9	-1.0	-0.4
Reaction time trials completed	1.5	2.2	5.0	2.2	1.7	-2.0	1.5	1.1	-1.5	0.2	-0.0
Reaction time trials AUC	1.6	2.4	5.3	2.3	1.8	-2.0	1.5	1.1	-1.6	0.3	0.0
Run reversals in cocaine runway, females	1.1	1.0	2.9	0.2	0.8	-0.2	0.9	0.3	1.3	-1.4	-1.7
Run reversals in cocaine runway, males	1.8	1.7	4.4	-2.1	-1.9	1.6	-1.4	0.1	0.9	-0.6	0.3
Latency to leave start box in cocaine runway	0.2	0.3	1.1	0.3	-0.3	0.4	-0.5	-1.1	0.0	0.5	0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.1	-0.2	0.4	-0.5	-0.7	-0.0	0.6	0.3
Latency to leave start box in cocaine runway, M	0.3	0.3	0.7	0.8	-0.2	-0.0	-0.3	-0.8	-0.5	0.4	0.5
Std. dev. time between licks in bursts	3.6	4.3	8.9	-2.9	-3.0	2.4	-2.7	-0.0	0.2	0.5	1.9
Total sessions with >9 infusions	1.0	1.1	3.0	-1.3	-0.5	0.2	-0.0	0.2	1.7	-1.4	-1.3
Short access day 1 total inactive lever presses	1.3	1.5	3.4	-1.8	-1.4	1.1	-0.7	-0.0	1.7	-1.1	-0.8
Short access day 10 total inactive lever presses	4.0	4.4	12.1	1.8	0.0	-0.7	-0.8	-0.1	-3.5	3.0	3.2
Short access day 1 total infusions	2.0	2.2	5.1	-2.0	-1.5	1.6	-0.9	-0.9	2.3	-1.0	-0.9
Short access day 10 total infusions	0.1	0.1	0.3	-0.3	0.1	0.0	0.3	0.6	0.3	-0.3	-0.3
Short access total infusions	0.9	1.0	2.8	-1.2	-0.5	0.6	-0.0	0.3	1.7	-1.4	-1.2
Short access day 1 locomotion	0.3	0.4	0.9	0.1	-0.6	0.1	-0.8	-0.3	-0.5	0.7	1.0
Short access day 10 total locomotion	0.8	0.9	1.9	-0.7	-1.3	0.4	-1.3	-0.1	-0.4	1.1	1.4
Short access total locomotion	0.1	0.1	0.3	-0.5	-0.4	-0.3	-0.3	0.5	0.2	-0.1	0.1
One hour access (0.3 mA shock)	0.5	0.6	1.0	-0.2	-0.8	1.0	-1.0	-0.7	-0.1	0.9	0.9
Compulsive drug intake	0.8	0.8	2.7	0.1	-0.1	1.1	-0.7	-1.1	-0.3	1.6	0.9
One hour access (shock baseline)	1.0	1.2	2.4	-1.5	-0.9	0.3	-0.2	0.7	1.5	-1.6	-1.0
Social response proportion	0.1	0.1	0.6	-0.8	-0.3	0.4	-0.2	-0.1	0.2	0.1	0.1
Social responses	0.4	0.5	1.3	-0.1	-0.2	0.1	-0.3	-0.5	-1.0	1.1	1.1
Social time	2.3	3.1	7.1	-1.4	-1.6	1.1	-1.7	-1.0	-1.6	2.3	2.7
Soleus weight	2.4	7.1	25.2	-5.0	-3.5	2.8	-2.6	0.6	1.7	-0.9	0.6
Bone: stiffness	0.7	1.1	2.4	0.7	1.6	-1.4	1.3	1.0	-0.8	-0.3	-0.3
Tibialis anterior weight	0.3	0.9	2.7	0.4	0.2	0.5	-0.4	-1.6	-0.6	1.6	0.9
Time to tail flick, vehicle, before self-admin	2.1	2.2	7.9	1.4	0.2	-1.0	0.0	0.7	-2.8	1.4	2.0
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.7	-0.1	0.3	-0.5	0.1	-0.5	-0.7	0.8	0.5
Time to tail flick, test, before self-admin	1.3	1.2	3.2	1.3	-0.1	-0.6	-0.3	-0.1	-1.8	1.4	1.7
Time to tail flick, test, after self-admin	0.5	0.5	1.4	-0.2	-1.1	0.2	-1.2	-0.4	-0.4	0.4	0.9
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	4.0	-0.7	0.3	0.3	0.3	-0.7	2.0	-1.0	-1.7
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.3	0.5	-0.7	0.4	0.4	0.2	-0.8	-0.7
Tibia length	0.6	1.7	8.7	-1.7	-0.1	-0.8	0.4	2.9	-0.4	-1.2	-0.1
Ambulatory time before self-admin	0.6	0.6	1.6	0.3	-0.1	-0.6	-0.0	1.0	-1.3	0.6	1.0
Ambulatory time after self-admin	0.7	0.7	1.9	0.2	0.3	-0.6	0.2	0.7	-1.4	1.3	1.1
Bone: tissue strength	0.6	0.6	1.1	0.7	0.9	-0.7	1.0	0.3	0.5	-0.6	-1.1
Total heroin consumption	0.1	0.1	0.5	0.0	0.3	0.2	0.1	-0.1	-0.4	0.7	0.4
Bone: trabecular number	0.2	0.3	1.6	0.4	0.2	0.5	-0.2	-1.3	0.2	0.6	0.1
Bone: trabecular spacing	0.7	0.9	3.1	-0.2	0.6	-1.1	1.0	1.7	-0.1	-0.9	-0.7
Bone: trabecular thickness	0.3	0.3	0.9	-0.3	0.2	-0.0	0.2	0.6	0.6	-0.9	-0.7
Bone: trabecular tissue density	0.7	1.0	2.1	-1.5	-1.3	1.1	-0.9	0.5	1.1	-0.9	-0.2
Water consumed over 24 hours	0.2	0.2	1.1	0.0	-0.1	0.2	-0.2	-1.0	0.4	0.5	-0.1
Number of responses in last shaping day	4.3	4.5	8.3	-2.6	-2.4	2.7	-1.8	-1.4	2.9	-1.3	-0.9