Ddx5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Ddx5	0.06	0.03	9.3e-10	0.08	0.08	0.07	0.08	9.1e-09	5.2e-09	2.7e-08	2.5e-09
2	IC	mRNA stability	Ddx5	0.09	0.05	1.9e-03	0.07	0.05	0.05	0.06	6.0e-04	4.7e-03	4.1e-03	1.9e-03
3	NAcc	mRNA stability	Ddx5	0.04	0.02	3.0e-07	0.06	0.05	0.05	0.06	1.2e-09	1.6e-07	1.6e-08	6.4e-09
4	Adipose	alternative TSS	XM_008768313.4	0.03	0.02	8.1e-03	0	0.02	0.01	0.01	1.4e-01	3.0e-03	1.6e-02	3.4e-02
5	Adipose	alternative TSS	NM_001007613.1	0.03	0.02	8.1e-03	0	0.02	0.01	0.01	1.3e-01	3.5e-03	2.0e-02	3.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.4	0.8	0.9	0.6	0.4	0.5	-0.5
Area under the delay curve	0.1	0.1	0.3	-0.4	-0.6	0.2	0.3	-0.3
BMI with tail	0.5	1.8	3.5	1.4	-0.2	0.0	-1.9	1.9
BMI without tail	0.8	2.5	4.4	1.9	0.3	0.2	-2.1	2.1
Body weight	1.1	4.9	10.5	3.2	1.7	1.8	-2.0	1.9
Weight adjusted by age	0.3	0.5	1.1	-1.0	-0.9	-0.0	0.6	-0.6
Bone surface	2.1	3.8	9.1	3.0	2.6	1.6	0.4	-0.5
Bone volume	1.4	2.5	6.2	2.5	2.0	1.4	0.3	-0.3
Breakpoint value in progressive ratio session	0.0	0.1	0.3	-0.1	-0.5	0.1	0.0	-0.1
Number of licking bursts	0.1	0.2	0.5	-0.1	-0.2	-0.1	0.6	-0.7
Context. condit. distance diff. score	0.1	0.1	0.4	-0.1	-0.1	-0.6	-0.1	0.1
Locomotion velocity, session 1	0.2	0.2	0.7	0.8	0.5	0.3	0.3	-0.4
Locomotion distance, session 1	0.2	0.3	0.6	0.2	-0.3	-0.6	0.7	-0.7
Locomotion velocity, session 2	0.2	0.3	1.0	1.0	0.6	0.0	0.1	-0.2
Locomotion distance, session 2	0.5	0.7	1.1	-0.0	-0.6	-1.0	1.0	-1.1
Locomotion velocity, session 3	1.7	1.9	2.4	-1.0	-1.5	-1.5	1.4	-1.4
Locomotion distance, session 3	0.4	0.5	1.1	0.1	-0.2	-0.5	1.0	-1.0
Stereotopy head waving bouts, day 3	0.5	0.5	1.1	-1.1	-1.0	-0.5	0.5	-0.4
Stereotopy head waving duration, day 3	0.6	0.7	1.4	-1.1	-1.2	-0.6	0.5	-0.5
Locomotion velocity, session 7	0.1	0.1	0.3	-0.2	-0.3	-0.6	0.2	-0.2
Locomotion distance, session 7	0.0	0.1	0.1	-0.0	-0.2	-0.3	-0.3	0.3
Stereotopy head waving bouts, day 7	1.6	1.9	2.2	-1.2	-1.4	-1.2	1.5	-1.5
Stereotopy head waving duration, day 7	2.4	2.8	3.3	-1.7	-1.7	-1.3	1.8	-1.8
Locomotion velocity, session 8	0.6	0.8	1.8	1.3	1.2	0.7	-0.3	0.3
Locomotion distance, session 8	0.1	0.1	0.2	0.4	0.1	-0.5	0.1	-0.1
Degree of sensitization distance	0.6	0.6	1.2	0.4	0.6	0.6	-1.1	1.1
Degree of sensitization stereotypy	2.5	2.7	3.2	-1.3	-1.7	-1.8	1.7	-1.7
Conditioned locomotion	0.6	0.7	1.5	0.5	0.4	0.7	-1.2	1.2
Cocaine response after cond. corrected	0.4	0.5	0.9	-0.7	-0.3	-0.2	1.0	-1.0
Cocaine response after cond. not corrected	1.3	1.6	3.4	-0.8	-0.4	-0.6	1.8	-1.8
Cocaine response before conditioning	0.8	0.9	1.8	-0.3	-0.6	-0.8	1.3	-1.3
Saline control response	1.7	2.3	5.0	0.9	0.2	1.0	-2.2	2.2
Bone: connectivity density	0.5	0.8	2.1	1.5	1.2	0.7	0.3	-0.3
Bone: cortical apparent density	3.0	4.2	6.2	-2.5	-2.5	-2.2	1.4	-1.3
Bone: cortical area	0.5	0.8	1.3	0.8	-0.2	-0.8	1.1	-1.1
Bone: cortical porosity	1.3	1.4	3.9	2.0	1.4	1.1	0.0	-0.1
Bone: cortical porosity	0.7	0.8	2.6	1.6	0.8	0.6	0.4	-0.5
Bone: cortical thickness	8.7	14.5	19.1	-3.6	-4.4	-4.4	3.3	-3.2
Bone: cortical thickness	4.8	5.7	9.1	-2.2	-2.5	-3.0	2.0	-2.0
Bone: cortical tissue density	2.8	3.8	6.0	-2.4	-2.4	-2.1	1.2	-1.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.3	1.1	0.5	0.8	-0.9	0.9
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.6	0.4	0.5	-0.6	0.5
Condit. Reinf. active responses	1.2	1.4	2.3	1.5	0.8	1.3	-1.2	1.1
Condit. Reinf. inactive responses	0.4	0.5	1.2	1.1	0.6	0.9	-0.4	0.4
Incentive salience index mean	0.5	0.6	1.3	1.2	0.6	0.9	-0.5	0.4
Condit. Reinf. lever presses	0.0	0.1	0.1	0.3	-0.1	0.4	0.2	-0.3
Condit. Reinf. active minus inactive responses	0.9	1.1	3.8	1.9	1.0	0.5	0.4	-0.6
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.3	1.1	0.8	0.8	0.2	-0.3
Condit. Reinf. active responses	1.6	2.3	6.6	2.6	1.6	1.1	-0.7	0.6
Condit. Reinf. inactive responses	1.1	1.4	3.0	1.7	0.8	0.4	-1.3	1.3
Condit. Reinf. lever presses	0.3	0.4	1.7	1.3	0.5	0.1	-0.2	0.2
Condit. Reinf. lever reinforcers received	1.4	2.0	5.8	2.4	1.6	1.0	-0.7	0.6
Conditioned reinforcement - actives	0.1	0.1	0.2	0.3	-0.2	-0.2	-0.5	0.4
Conditioned reinforcement - inactives	0.6	0.8	2.4	1.6	1.0	-0.1	-0.6	0.6
Conditioned locomotion	1.3	1.7	2.8	1.7	1.0	1.2	-1.2	1.2
Patch foraging indifference point 0 sec	1.2	2.3	4.9	2.2	1.1	1.3	-1.4	1.3
Patch foraging indifference point AUC	0.6	0.8	1.9	1.4	1.1	0.8	-0.5	0.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	-0.9	-0.6	0.2	0.3	-0.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.3	-0.6	0.2	-0.2	0.2
Delay disc. indifference point, 2s delay	0.4	0.5	0.8	0.5	0.5	0.9	0.7	-0.8
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.7	0.2	0.5	-0.6	0.6
Delay disc. indifference point, 4s delay	1.0	1.1	1.4	-1.1	-1.0	-0.6	1.2	-1.2
Delay disc. indifference point, 8s delay	0.2	0.3	0.6	-0.7	-0.8	0.0	0.4	-0.4
Indifference point function ln k	1.0	1.7	2.6	-1.3	-1.6	-1.5	1.0	-1.0
Indifference point function log k	1.0	1.7	2.6	-1.3	-1.6	-1.5	1.0	-1.0
Patch foraging total patch changes 0 sec	1.3	2.4	5.1	2.2	1.3	1.3	-1.4	1.3
Patch foraging total patch changes 12 sec	4.4	5.6	8.6	2.9	2.3	2.6	-2.0	1.9
Patch foraging total patch changes 18 sec	1.2	1.9	3.8	1.9	1.2	1.0	-1.3	1.2
Patch foraging total patch changes 24 sec	0.7	1.3	3.8	1.9	1.1	0.9	-0.6	0.6
Patch foraging total patch changes 6 sec	1.3	1.9	5.1	2.3	1.3	1.1	-0.9	0.9
Patch foraging time to switch 0 sec	0.1	0.1	0.4	-0.6	-0.3	0.2	-0.2	0.3
Patch foraging water rate 0 sec	0.6	1.2	2.9	1.7	1.1	0.5	-0.8	0.8
Patch foraging water rate 12 sec	1.5	3.1	4.9	-1.1	-1.3	-2.2	1.9	-1.9
Patch foraging water rate 18 sec	1.3	2.0	3.2	-0.5	-0.9	-1.6	1.8	-1.8
Patch foraging water rate 24 sec	0.5	0.8	1.5	-0.3	-0.3	-0.9	1.2	-1.2
Patch foraging water rate 6 sec	0.5	0.7	1.0	-0.5	-0.8	-1.0	0.9	-0.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	-0.3	-0.4	-0.1	-0.8	0.8
Distance traveled before self-admin	1.3	1.7	2.6	-1.1	-1.0	-1.1	1.6	-1.6
Distance traveled after self-admin	0.7	0.8	1.7	-0.2	-0.4	-0.9	1.3	-1.3
Extensor digitorum longus weight	1.2	4.8	9.7	-1.8	-1.0	1.0	-3.0	3.1
Bone: elastic displacement	2.9	3.4	3.8	-1.8	-1.8	-1.9	1.8	-1.8
Bone: elastic work	0.3	0.4	0.7	-0.1	-0.5	-0.8	0.8	-0.8
Bone: endosteal estimation	10.1	22.2	41.1	6.4	5.9	4.5	-2.7	2.6
Bone: endosteal perimeter	10.1	21.6	41.5	6.4	5.8	4.7	-2.5	2.3
Epididymis fat weight	0.3	0.9	1.3	1.0	0.6	0.9	-1.1	1.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.1	0.5	-0.1	0.4	-0.3
Delta time in open arm before/after self-admin	0.5	0.5	1.0	-0.6	-0.6	0.1	-1.0	1.0
Diff in mean of infusions in LGA sessions	0.8	1.0	2.0	-1.4	-1.4	-1.0	0.3	-0.2
Delay discount exponential model param	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3	0.3
Extinction: sum of active levers before priming	0.2	0.2	0.5	-0.3	-0.7	0.3	-0.5	0.5
Active lever presses in extinction session 6	0.6	0.6	0.9	1.0	0.3	0.6	-0.9	0.9
Bone: final force	0.9	1.4	2.7	0.9	0.4	-0.8	1.6	-1.6
Bone: final moment	0.9	1.4	2.8	0.9	0.4	-0.8	1.7	-1.7
Food consumed during 24 hour testing period	1.6	2.3	3.0	1.7	1.0	1.5	-1.6	1.6
Glucose	1.2	1.9	2.3	-1.5	-1.4	-1.3	1.4	-1.4
Heart weight	1.3	2.0	2.6	-1.3	-1.6	-1.1	1.5	-1.5
Delay discount hyperbolic model param	0.1	0.1	0.2	0.1	0.2	-0.5	-0.3	0.3
Intermittent access intake day 1-15 change	0.3	0.6	0.9	0.2	0.9	0.5	-0.9	0.9
Intermittent access intake escalation	0.4	0.8	1.0	0.6	1.0	0.7	-1.0	1.0
Intermittent access intake escalation 2	1.5	1.7	2.4	1.0	1.5	1.2	-1.4	1.4
Intermitt. access day 1 inactive lever presses	0.7	2.6	3.9	2.0	1.5	1.6	-1.5	1.5
Intermitt. access day 15 inactive lever presses	1.6	3.3	5.6	1.5	1.3	1.2	-2.3	2.4
Intermitt. access escalation Index	2.2	3.2	3.5	-1.8	-1.8	-1.6	1.9	-1.9
Intermittent access day 1 total infusions	0.3	0.5	0.6	0.7	-0.4	-0.8	0.7	-0.8
Intermittent access day 15 total infusions	0.3	0.4	1.2	1.1	0.5	0.2	-0.6	0.6
Intermittent access terminal intake (last 3 days)	1.4	1.9	4.1	2.0	1.5	0.8	-1.1	1.0
Intermittent access total infusions	0.6	0.7	3.0	1.7	0.7	0.0	-0.2	0.1
Intermittent access day 1 locomotion	0.5	0.6	2.9	1.7	0.2	0.3	-0.1	0.1
Intermittent access day 15 total locomotion	1.2	2.1	6.2	2.5	1.4	0.9	-0.9	0.8
Intermittent access total locomotion	1.9	2.2	8.4	2.9	1.2	0.7	-0.7	0.7
Intermittent access standard deviation	0.4	0.9	1.5	1.2	1.1	0.5	-0.8	0.9
Left kidney weight	0.8	3.9	6.2	-0.6	-1.1	-2.4	2.5	-2.5
Right kidney weight	0.9	3.9	7.3	-0.5	-1.0	-2.0	2.7	-2.7
Cocaine induced anxiety	1.1	1.6	2.4	-0.9	-0.8	-1.3	1.5	-1.5
Post-drug Anxiety	1.5	1.6	2.2	-1.0	-0.8	-1.4	1.5	-1.4
Baseline Anxiety	0.1	0.2	0.2	-0.5	-0.4	-0.4	-0.3	0.3
Tail length	1.0	3.9	8.7	3.0	2.2	1.7	-1.2	1.2
Length with tail	1.1	4.9	9.4	3.1	2.8	2.5	-0.6	0.5
Length without tail	0.4	1.2	2.8	1.0	1.4	1.7	-0.1	0.1
Times rat made contact with spout	0.4	0.5	1.1	1.0	0.8	0.7	-0.2	0.2
Lifetime Intake	0.5	0.7	2.9	1.7	0.5	-0.2	-0.3	0.2
Liver weight, left	1.5	2.5	6.6	2.6	2.1	1.0	0.5	-0.6
Liver weight, right	2.3	4.1	6.8	-1.2	-1.3	-2.6	2.3	-2.3
Locomotor activity	0.6	1.0	2.4	0.3	-1.0	-1.5	0.9	-0.9
Locomotor testing distance	0.3	0.5	1.5	0.4	-1.0	-1.2	0.1	-0.1
Locomotor testing rearing	0.3	0.6	1.2	0.9	0.2	-0.3	-1.1	1.0
Locomotion in novel chamber	0.8	1.0	2.6	0.1	0.0	-0.3	1.6	-1.6
Locomotion in novel chamber post-restriction	1.1	1.8	3.5	1.8	1.9	1.3	0.2	-0.3
Fecal boli incidents, locomotor time 1	0.3	0.4	1.3	-0.1	0.1	1.1	-0.7	0.6
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.0	0.1	0.3	-0.6	0.6
Time >=10cm from walls, locomotor time 1	2.1	2.3	3.6	-1.0	-0.5	-1.6	1.9	-1.9
Bouts of movement, locomotor time 1	0.3	0.3	0.6	-0.5	-0.4	-0.2	-0.7	0.7
Total resting periods, locomotor time 1	0.2	0.3	0.6	-0.4	-0.1	0.0	-0.7	0.8
Rest time, locomotor task time 1	0.3	0.4	0.6	-0.2	0.4	0.8	-0.7	0.7
Distance moved, locomotor task time 1	0.1	0.1	0.5	0.7	0.5	0.0	-0.1	0.1
Vertical activity count, locomotor time 1	0.1	0.1	0.2	0.4	0.3	-0.2	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.5	0.0	0.4	-0.4	0.7	-0.7
Bouts of movement, locomotor time 2	0.3	0.4	0.7	-0.7	-0.6	-0.2	-0.8	0.8
Total resting periods, locomotor time 2	0.3	0.5	0.8	-0.9	-0.8	-0.4	-0.6	0.6
Rest time, locomotor task time 2	1.2	1.5	4.7	-2.2	-1.5	-0.5	0.4	-0.4
Distance moved, locomotor task time 2	0.4	0.5	1.3	1.1	0.9	0.1	-0.2	0.3
Vertical activity count, locomotor time 2	1.0	1.4	2.9	1.7	1.3	0.7	-1.0	1.0
Light reinforcement 1	0.3	0.7	2.5	-0.6	-1.6	-0.3	-0.5	0.5
Light reinforcement 2	0.1	0.2	0.3	-0.1	-0.5	0.3	-0.6	0.6
Bone: marrow area	9.8	21.5	39.8	6.3	5.9	4.4	-2.6	2.5
Bone: maximum diameter	1.7	3.2	8.4	2.9	2.3	1.5	-0.1	-0.0
Bone: maximum force	0.6	1.0	1.6	1.3	0.5	-0.4	1.2	-1.2
Bone: maximum moment	0.6	1.0	1.7	1.3	0.6	-0.4	1.2	-1.2
Mean time between licks in bursts	0.1	0.3	0.6	0.5	0.7	0.7	-0.3	0.3
Mean num. licks in bursts	0.4	0.6	1.2	0.6	0.5	0.6	-1.1	1.1
Cd content in liver	0.5	0.5	1.1	-1.1	0.1	0.2	-0.8	0.9
Co content in liver	0.1	0.2	0.5	-0.7	-0.6	-0.1	0.0	0.0
Cu content in liver	0.7	0.8	1.5	0.5	0.6	1.2	-1.0	1.0
Fe content in liver	0.4	0.5	1.1	0.2	-0.0	-0.4	1.0	-1.1
K content in liver	0.3	0.3	0.4	0.6	0.3	0.6	0.5	-0.6
Mg content in liver	0.1	0.1	0.2	-0.3	-0.1	0.4	-0.0	0.0
Mn content in liver	1.1	1.2	2.7	-0.1	-0.4	-0.9	1.6	-1.6
Na content in liver	0.1	0.1	0.2	0.2	-0.4	0.4	0.3	-0.4
Rb content in liver	2.5	2.9	3.8	-1.6	-1.3	-1.7	1.9	-1.9
Se content in liver	1.7	2.0	2.8	-1.4	-1.7	-1.2	1.3	-1.4
Sr content in liver	0.4	0.3	0.8	0.9	0.7	0.5	-0.2	0.2
Zn content in liver	0.5	0.5	0.7	-0.7	-0.5	-0.6	0.8	-0.8
Bone: minimum diameter	6.6	12.0	25.4	5.0	4.1	3.4	-1.8	1.7
Time in familiar zone, hab. session 1	2.0	1.9	2.5	1.1	1.3	1.6	-1.5	1.4
Time in novel zone, hab. session 1	1.8	1.8	3.2	-1.1	-1.4	-1.8	1.1	-1.1
Total zone transitions, hab. session 1	0.2	0.3	0.7	0.3	-0.3	-0.8	0.6	-0.6
Total locomotion distance, hab. session 1	0.3	0.5	0.7	0.8	-0.0	-0.8	0.7	-0.7
Locomotion velocity, hab. session 1	0.3	0.4	1.0	1.0	0.4	-0.3	0.6	-0.6
Time in familiar zone, hab. session 2	1.6	1.7	2.7	1.6	1.4	1.1	-1.2	1.1
Time in novel zone, hab. session 2	1.3	1.3	1.6	-1.3	-1.0	-1.1	1.2	-1.1
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	-0.2	-0.5	0.3	-0.3
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.7	0.2	0.1	-0.4	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.4	0.6	0.2	0.1	-0.2	0.3
Novel to familiar place preference ratio	0.2	0.2	0.5	0.7	0.6	0.2	-0.1	0.1
Novelty place preference	0.1	0.1	0.2	0.5	0.5	-0.0	0.1	-0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	0.3	-0.3	0.3	-0.3
Total zone transitions, NPP test	0.8	1.2	1.7	-0.3	-1.0	-1.3	1.3	-1.3
Total locomotion distance, NPP test	0.2	0.3	0.6	0.8	0.3	-0.4	0.5	-0.5
Locomotion velocity, NPP test	0.0	0.0	0.1	0.4	-0.2	-0.2	0.1	-0.1
Intraocular pressure	0.6	0.9	1.9	-0.1	-0.7	0.3	-1.4	1.4
Delta distance traveled before/after self-admin	0.2	0.2	0.8	-0.0	-0.5	-0.9	0.2	-0.2
Delta ambulatory time before/after self-admin	0.0	0.1	0.1	0.4	0.0	-0.0	-0.2	0.2
Parametrial fat weight	0.4	0.9	2.5	0.8	1.6	1.1	0.2	-0.2
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.6	0.2	0.3	-0.7	0.7
Pavlov. Cond. magazine entry latency	0.6	0.8	2.5	1.6	0.8	0.9	-0.3	0.2
Pavlov. Cond. change in total contacts	0.4	0.4	1.2	1.1	0.3	0.6	-0.5	0.4
Pavlov. Cond. index score	0.3	0.4	1.7	1.3	0.5	0.4	0.0	-0.1
Pavlov. Cond. latency score	0.2	0.3	1.3	1.1	0.3	0.2	0.2	-0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.8	0.9	0.3	0.4	0.1	-0.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.4	-1.2	-0.4	-0.8	0.4	-0.3
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.4	0.7	-0.0	0.7	-1.2	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.6	1.3	0.5	0.4	0.1	-0.1
Pavlov. Cond. response bias	0.5	0.6	2.0	1.4	0.6	0.8	0.1	-0.2
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	-0.0	0.1	-0.4	0.5
Pavlov. Cond. magazine entry latency	1.9	2.3	3.0	-1.5	-1.1	-1.3	1.7	-1.7
Pavlov. Cond. change in total contacts	0.1	0.2	0.6	0.7	0.4	0.5	-0.1	0.1
Pavlov. Cond. index score	0.3	0.4	1.0	-0.1	-0.3	-0.5	0.9	-1.0
Pavlov. Cond. latency score	0.7	0.9	1.8	-0.3	-0.5	-0.8	1.3	-1.3
Pavlov. Cond. lever contacts	0.0	0.1	0.1	0.2	-0.3	-0.2	0.3	-0.3
Pavlov. Cond. magazine entry number	3.4	4.2	5.2	2.0	1.6	2.0	-2.3	2.3
Pavlov. Cond. intertrial magazine entries	10.2	15.4	18.5	4.3	3.8	4.0	-3.8	3.8
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.3	-0.2	-0.3	-0.6	1.1	-1.1
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.0	-0.3	-0.4	0.8	-0.8
Time in closed arm before self-admin	0.5	0.7	1.4	-0.2	-0.7	-1.2	0.9	-0.8
Time in closed arm after self-admin	0.6	0.6	1.4	0.1	0.4	-0.4	1.2	-1.1
Time in open arm before self-admin	1.3	1.4	2.2	-0.9	-0.7	-1.1	1.5	-1.5
Time in open arm after self-admin	0.3	0.3	0.6	-0.2	-0.2	0.4	-0.8	0.8
Bone: periosteal estimation	4.0	8.5	21.0	4.6	3.7	2.5	-1.0	0.9
Bone: periosteal perimeter	1.6	2.8	7.7	2.8	2.1	1.3	0.3	-0.4
Bone: post-yield work	0.8	1.2	3.0	1.7	1.6	0.7	-0.1	0.0
Progressive ratio test 1 active lever presses	0.3	0.4	1.7	1.3	0.1	0.0	-0.2	0.2
Progressive ratio test 1 breakpoint	0.4	0.5	2.2	1.5	0.3	0.3	-0.4	0.4
Progressive ratio test 1 inactive lever presses	0.9	1.2	5.0	2.2	0.8	-0.0	-0.5	0.5
Progressive ratio test 2 active lever presses	1.2	1.4	3.4	1.9	1.0	1.0	-0.9	0.8
Progressive ratio test 2 breakpoint	1.4	1.6	4.0	2.0	1.2	1.1	-0.9	0.9
Progressive ratio test 2 inactive lever presses	0.6	1.0	2.3	1.5	0.6	0.3	-1.1	1.0
Incentive Sensitization - Responses	0.9	1.3	2.6	1.6	1.3	1.1	-0.8	0.7
Incentive Sensitization - Breakpoint	1.0	1.4	2.8	1.7	1.3	1.1	-0.7	0.7
Sum of active levers in priming session hrs 5-6	1.1	1.0	3.1	-1.4	-1.8	-0.4	-0.1	0.0
Progressive ratio	0.1	0.1	0.2	0.3	0.5	0.3	0.3	-0.3
Food seeking constrained by brief footshock	3.6	4.4	7.1	2.6	2.7	1.8	-1.6	1.5
Seeking ratio, punishment vs. effort	1.0	1.5	2.1	1.4	1.0	1.0	-1.3	1.3
Retroperitoneal fat weight	0.3	1.3	2.1	1.4	1.2	1.1	-1.0	1.0
Reaction time number correct	1.2	2.3	2.8	-1.4	-1.3	-1.4	1.7	-1.7
Reaction time mean minus median	0.1	0.2	0.4	-0.4	-0.1	0.4	-0.6	0.6
Reaction time mean minus median AUC	0.3	0.8	1.4	-1.2	-1.1	-0.7	0.7	-0.7
Reaction time num false alarms	0.6	0.9	2.7	1.6	1.1	0.5	0.3	-0.4
Reaction time num false alarms AUC	0.7	1.1	3.1	1.8	1.3	0.8	0.2	-0.3
Reaction time trials correct on left	1.2	2.3	2.8	-1.4	-1.3	-1.4	1.7	-1.7
Reaction time trials on left	1.2	2.2	2.8	-1.4	-1.3	-1.4	1.7	-1.7
Reaction time mean	0.2	0.3	0.7	-0.8	-0.4	-0.5	0.5	-0.5
Reaction time mean AUC	0.3	0.5	1.2	-1.1	-0.6	-0.7	0.4	-0.4
Median of all reaction times	0.4	0.6	0.8	-0.9	-0.6	-0.8	0.7	-0.7
Reaction time omissions	0.5	0.7	1.0	0.8	1.0	0.8	-0.8	0.8
Reaction time false alarm rate	1.5	2.1	4.6	2.1	1.8	1.3	-0.7	0.6
Reaction time premature initiation rate	0.4	0.5	1.0	0.7	-0.0	0.4	-1.0	1.0
Reaction time premature initiations	0.0	0.1	0.3	0.0	-0.5	-0.1	-0.1	0.1
Std. dev. reaction times	0.1	0.2	0.2	-0.2	0.5	0.4	-0.4	0.5
Reaction time trials completed	1.2	2.2	2.8	-1.4	-1.3	-1.4	1.7	-1.7
Reaction time trials AUC	1.0	2.0	2.6	-1.3	-1.2	-1.3	1.6	-1.6
Run reversals in cocaine runway, females	0.4	0.4	0.8	-0.7	-0.2	0.3	-0.8	0.9
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.2	-0.1	0.3	0.1	-0.1
Latency to leave start box in cocaine runway	0.2	0.2	0.2	-0.5	-0.5	-0.3	0.4	-0.4
Latency to leave start box in cocaine runway, F	1.3	1.5	1.6	-1.0	-1.3	-1.3	1.3	-1.3
Latency to leave start box in cocaine runway, M	0.6	0.6	0.8	0.4	0.7	0.9	-0.8	0.8
Std. dev. time between licks in bursts	0.2	0.2	0.6	0.0	0.1	0.3	-0.7	0.8
Total sessions with >9 infusions	0.8	1.0	2.5	-0.5	-1.6	-1.3	0.4	-0.4
Short access day 1 total inactive lever presses	0.4	0.5	2.0	1.4	0.4	-0.6	-0.1	0.1
Short access day 10 total inactive lever presses	0.4	0.9	1.8	0.6	0.4	0.5	-1.3	1.3
Short access day 1 total infusions	1.0	1.4	3.5	-0.5	-1.9	-1.6	0.5	-0.5
Short access day 10 total infusions	0.7	0.8	3.0	1.7	0.5	-0.2	-0.7	0.7
Short access total infusions	0.3	0.3	0.8	0.8	-0.4	-0.9	-0.0	0.0
Short access day 1 locomotion	0.4	0.5	1.2	0.4	-1.1	-0.4	-0.7	0.7
Short access day 10 total locomotion	1.9	3.6	6.0	2.5	1.2	2.0	-1.8	1.8
Short access total locomotion	0.6	0.7	1.5	1.2	-0.2	0.3	-1.0	0.9
One hour access (0.3 mA shock)	0.2	0.3	0.8	0.9	0.6	0.1	-0.4	0.3
Compulsive drug intake	1.1	1.3	2.5	-0.8	-0.5	-0.9	1.6	-1.6
One hour access (shock baseline)	0.7	1.1	1.7	1.3	1.0	0.5	-1.2	1.1
Social response proportion	0.2	0.2	0.4	-0.6	-0.6	-0.4	0.3	-0.3
Social responses	0.1	0.2	0.5	0.0	-0.4	-0.7	0.3	-0.3
Social time	0.1	0.1	0.2	-0.3	0.1	0.4	-0.4	0.3
Soleus weight	0.1	0.3	0.6	-0.2	-0.8	-0.4	0.5	-0.5
Bone: stiffness	0.6	1.1	1.9	1.1	0.5	-0.4	1.3	-1.4
Tibialis anterior weight	1.1	3.9	8.2	0.5	0.2	1.7	-2.8	2.9
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.9	-0.1	0.5	0.4	1.4	-1.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.2	-0.1	0.1	0.5	-0.5
Time to tail flick, test, before self-admin	0.1	0.2	0.3	0.2	0.4	0.2	-0.5	0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.2	0.0	-0.1	0.4	-0.0	0.0
Delta time to tail flick, vehicle, before/after SA	1.6	1.5	2.2	1.1	1.1	0.9	-1.5	1.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.1	0.1	0.3	0.7	-0.7
Tibia length	1.3	3.7	7.1	-0.7	-1.1	-1.6	2.7	-2.7
Ambulatory time before self-admin	0.8	1.3	2.4	-0.7	-0.6	-0.9	1.5	-1.5
Ambulatory time after self-admin	0.4	0.4	0.7	-0.1	-0.4	-0.8	0.8	-0.9
Bone: tissue strength	3.2	3.2	4.4	-1.3	-1.4	-1.8	2.1	-2.1
Total heroin consumption	0.4	0.5	1.2	0.2	-0.4	-0.2	1.0	-1.1
Bone: trabecular number	0.4	0.6	1.5	1.2	0.9	0.6	0.5	-0.5
Bone: trabecular spacing	0.1	0.2	0.3	-0.3	-0.1	0.1	-0.6	0.6
Bone: trabecular thickness	0.4	0.5	1.1	0.9	0.7	1.1	-0.1	0.1
Bone: trabecular tissue density	2.5	3.7	4.7	-1.6	-1.6	-2.0	2.2	-2.1
Water consumed over 24 hours	0.1	0.1	0.2	0.4	-0.1	-0.2	0.3	-0.3
Number of responses in last shaping day	0.1	0.1	0.4	-0.3	-0.4	-0.6	0.1	-0.1