Ddx42

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Ddx42 0.02 0.01 1.6e-03 0.02 0.02 0.02 0.02 3.2e-04 5.2e-04 6.3e-04 4.0e-04
2 BLA mRNA stability Ddx42 0.09 0.05 1.7e-04 0.09 0.04 0.05 0.06 3.0e-05 3.7e-03 1.7e-03 7.3e-04
3 Adipose gene expression Ddx42 0.12 0.05 7.5e-10 0.03 0.05 0.05 0.06 1.7e-04 3.5e-06 5.0e-06 7.6e-07
4 PL mRNA stability Ddx42 0.03 0.02 1.0e-03 0.03 0.02 0.01 0.02 4.1e-04 5.7e-03 9.4e-03 5.1e-03
5 RMTg mRNA stability Ddx42 0.23 0.1 1.9e-05 0.11 0.16 0.13 0.13 6.6e-04 6.5e-05 3.4e-04 2.2e-04
6 pVTA mRNA stability Ddx42 0.11 0.06 2.3e-04 0.03 0.04 0.05 0.03 4.2e-03 6.1e-04 1.0e-04 8.4e-04
7 NAcc mRNA stability Ddx42 0.02 0.02 6.5e-03 -0 0.01 0 0 7.1e-01 3.6e-02 2.4e-01 3.4e-01
8 Brain mRNA stability Ddx42 0.07 0.03 2.6e-05 0.01 0.05 0.04 0.04 1.4e-02 2.6e-05 1.4e-04 2.1e-04
9 Liver gene expression Ddx42 0.07 0.04 1.8e-04 0.04 0.04 0.04 0.03 4.4e-05 8.7e-05 7.2e-05 9.2e-05
10 Adipose mRNA stability Ddx42 0.13 0.05 5.4e-13 0.06 0.11 0.12 0.12 3.9e-07 1.3e-12 1.1e-13 5.0e-13
11 LHb mRNA stability Ddx42 0.55 0.12 8.3e-07 0.16 0.22 0.2 0.23 1.2e-04 6.8e-06 1.7e-05 4.1e-06
12 Liver mRNA stability Ddx42 0.05 0.03 1.4e-03 0.03 0.02 0.02 0.02 9.9e-05 6.4e-03 4.6e-03 1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.32.27.8-1.60.7-2.80.90.10.9-0.5-1.4-2.7-0.7-1.6-1.3
Area under the delay curve0.30.40.7-0.50.5-0.80.4-0.90.40.8-0.8-0.8-0.2-0.40.3
BMI with tail1.03.57.7-1.92.2-0.62.40.21.72.82.51.21.71.81.6
BMI without tail1.95.711.7-3.43.2-2.03.20.52.93.22.50.31.81.90.9
Body weight1.88.020.9-4.63.7-3.14.01.52.54.32.3-0.31.61.10.0
Weight adjusted by age0.40.61.31.1-0.80.7-1.0-1.1-1.00.3-0.60.5-0.4-0.00.9
Bone surface2.95.318.4-3.62.0-4.32.31.60.71.1-0.9-3.0-0.4-1.3-2.6
Bone volume2.44.416.1-3.21.8-4.02.11.11.01.0-1.0-2.9-0.4-1.2-2.0
Breakpoint value in progressive ratio session0.40.51.40.40.30.20.71.20.7-0.60.70.31.11.1-0.1
Number of licking bursts0.00.10.20.30.1-0.1-0.0-0.1-0.40.2-0.4-0.0-0.0-0.5-0.0
Context. condit. distance diff. score0.40.52.80.40.41.2-0.1-0.20.20.40.81.70.40.70.6
Locomotion velocity, session 11.11.23.6-1.71.0-1.90.50.40.50.0-0.6-1.3-0.7-0.9-1.6
Locomotion distance, session 10.50.61.1-0.9-0.1-0.7-0.3-0.80.4-0.0-1.1-1.0-0.8-1.0-0.9
Locomotion velocity, session 20.40.42.5-0.40.1-0.60.31.60.5-0.80.4-0.10.50.5-0.8
Locomotion distance, session 20.20.31.2-0.0-0.30.4-0.5-0.00.5-0.5-0.50.4-0.3-0.5-1.1
Locomotion velocity, session 30.50.61.20.7-0.7-0.1-0.7-0.7-0.1-0.9-0.9-0.5-1.1-1.1-0.6
Locomotion distance, session 30.30.30.70.3-0.6-0.4-0.3-0.0-0.4-0.3-0.8-0.6-0.7-0.8-0.8
Stereotopy head waving bouts, day 30.50.61.60.5-0.3-0.6-0.5-0.90.0-1.0-1.1-1.2-1.0-1.0-0.3
Stereotopy head waving duration, day 30.30.31.30.8-0.10.1-0.4-1.10.3-0.3-0.8-0.4-0.5-0.40.7
Locomotion velocity, session 70.40.41.00.9-1.00.2-0.7-0.4-0.3-1.0-0.4-0.2-0.7-0.5-0.7
Locomotion distance, session 70.20.31.10.6-0.70.5-0.4-0.30.10.10.10.60.31.10.7
Stereotopy head waving bouts, day 70.80.92.20.8-0.70.0-0.9-0.5-0.4-1.5-1.1-0.6-1.1-1.3-1.1
Stereotopy head waving duration, day 71.31.54.41.6-1.30.9-1.4-0.5-0.5-2.1-1.3-0.1-1.1-1.7-1.0
Locomotion velocity, session 80.60.82.8-0.51.10.50.81.00.21.11.21.70.30.0-0.7
Locomotion distance, session 80.50.73.30.10.41.20.10.31.20.30.71.80.80.60.3
Degree of sensitization distance0.70.71.9-0.60.40.50.4-0.10.51.20.71.10.81.41.0
Degree of sensitization stereotypy1.01.13.41.0-0.90.7-1.2-0.3-0.6-1.8-0.90.0-1.1-1.2-1.4
Conditioned locomotion1.11.33.7-0.20.50.41.00.71.60.81.10.81.91.41.7
Cocaine response after cond. corrected1.01.24.80.6-0.6-0.7-1.0-1.1-2.20.4-1.5-1.1-1.2-1.0-0.2
Cocaine response after cond. not corrected2.02.47.20.8-0.9-1.2-1.4-0.7-2.7-0.7-2.0-1.8-1.9-1.7-1.5
Cocaine response before conditioning0.70.93.20.3-0.3-0.6-0.30.5-0.2-1.6-0.8-1.0-1.0-1.0-1.8
Saline control response3.44.510.0-0.71.90.22.02.12.31.13.01.73.23.11.9
Bone: connectivity density1.42.17.9-1.91.1-2.81.20.71.1-0.2-1.0-2.2-0.3-1.0-1.6
Bone: cortical apparent density2.43.37.92.1-2.51.7-2.1-2.80.1-2.1-1.9-0.2-1.6-1.60.7
Bone: cortical area1.32.17.7-1.70.5-2.80.7-0.40.10.1-1.2-2.7-1.0-1.4-1.1
Bone: cortical porosity4.24.617.8-2.51.7-4.21.83.1-1.10.40.5-2.90.00.0-2.3
Bone: cortical porosity3.13.413.7-2.41.3-3.71.72.1-0.80.70.1-2.6-0.3-0.5-2.1
Bone: cortical thickness5.59.116.12.1-3.5-0.2-3.1-4.0-1.8-3.3-3.8-3.1-3.7-3.7-0.8
Bone: cortical thickness3.23.89.11.7-2.80.0-2.2-2.0-0.9-3.0-2.2-1.8-2.0-1.8-1.0
Bone: cortical tissue density2.23.17.02.1-2.41.7-2.0-2.60.2-2.1-1.8-0.1-1.5-1.50.7
Condit. Reinf. active minus inactive responses1.92.13.7-1.51.9-1.51.81.91.40.81.3-0.51.61.60.1
Condit. Reinf. active-inactive response ratio0.80.82.0-0.81.1-0.91.11.40.70.30.9-0.41.01.0-0.2
Condit. Reinf. active responses2.53.15.3-1.92.3-1.52.32.02.21.31.6-0.02.11.90.5
Condit. Reinf. inactive responses0.91.13.2-1.41.3-0.71.40.51.81.20.40.31.00.70.3
Incentive salience index mean1.51.84.2-1.71.5-1.71.72.11.30.30.9-1.01.20.8-0.7
Condit. Reinf. lever presses0.50.72.2-1.00.1-0.60.81.51.0-0.70.3-0.60.3-0.3-1.3
Condit. Reinf. active minus inactive responses2.83.710.3-2.72.5-3.22.51.92.11.10.0-1.61.10.4-1.2
Condit. Reinf. active-inactive response ratio2.02.37.8-1.92.0-2.81.71.90.90.4-0.0-1.60.70.0-1.4
Condit. Reinf. active responses3.54.99.2-2.92.9-2.83.02.32.81.61.1-0.92.01.5-0.4
Condit. Reinf. inactive responses2.02.77.5-1.41.5-0.62.01.02.71.21.50.52.12.31.3
Condit. Reinf. lever presses1.21.63.2-1.71.4-1.51.61.81.60.30.9-0.61.10.7-0.7
Condit. Reinf. lever reinforcers received3.14.38.3-2.82.8-2.92.82.12.51.40.9-1.11.81.3-0.4
Conditioned reinforcement - actives0.40.71.7-1.21.1-0.10.60.40.91.31.00.70.60.60.4
Conditioned reinforcement - inactives0.50.82.4-1.61.4-1.30.90.70.40.80.8-0.40.10.1-0.7
Conditioned locomotion1.72.25.7-2.42.3-1.61.61.51.31.61.4-0.40.80.7-0.4
Patch foraging indifference point 0 sec2.54.710.0-2.63.1-2.02.91.33.22.01.40.62.41.60.9
Patch foraging indifference point AUC0.50.81.7-1.21.1-0.11.10.51.31.20.90.60.70.10.4
Delay disc. indifference point, 0s delay0.30.30.80.8-0.60.6-0.3-0.90.1-0.0-0.80.10.3-0.30.9
Delay disc. indifference point, 16s delay0.60.71.9-0.71.0-1.20.8-0.50.51.4-0.2-0.80.40.31.0
Delay disc. indifference point, 2s delay0.80.92.1-1.00.7-1.10.8-0.70.90.9-1.4-1.1-0.6-1.3-0.8
Delay disc. indifference point, 24s delay1.21.34.0-1.71.5-1.21.4-0.21.52.00.4-0.20.50.10.6
Delay disc. indifference point, 4s delay1.11.12.40.8-0.8-0.5-1.0-1.0-1.4-0.6-1.5-1.5-1.3-1.0-0.6
Delay disc. indifference point, 8s delay0.40.41.4-0.20.0-0.70.1-1.10.40.0-1.1-1.2-0.5-0.70.2
Indifference point function ln k0.30.61.60.8-0.6-0.7-0.4-1.00.0-1.1-1.3-0.9-0.5-0.50.4
Indifference point function log k0.30.61.60.8-0.6-0.7-0.4-1.00.0-1.1-1.3-0.9-0.5-0.50.4
Patch foraging total patch changes 0 sec2.54.710.2-2.73.2-2.22.91.33.02.11.30.42.31.60.8
Patch foraging total patch changes 12 sec4.25.410.9-2.72.9-0.52.82.23.32.42.21.62.82.00.7
Patch foraging total patch changes 18 sec1.82.85.9-1.92.4-1.42.11.61.71.61.70.62.01.70.5
Patch foraging total patch changes 24 sec1.62.86.4-2.52.5-2.02.30.92.51.40.6-0.71.10.4-0.3
Patch foraging total patch changes 6 sec1.42.14.0-1.92.0-1.72.01.21.91.31.0-0.21.50.70.2
Patch foraging time to switch 0 sec0.30.51.91.0-1.00.5-0.90.4-1.4-1.0-0.0-0.5-0.30.3-0.3
Patch foraging water rate 0 sec0.91.94.8-2.22.0-1.72.00.51.91.50.7-0.10.80.50.1
Patch foraging water rate 12 sec1.22.55.30.7-1.2-0.8-1.3-2.0-1.7-0.9-2.1-1.7-2.3-1.9-1.3
Patch foraging water rate 18 sec0.81.33.2-0.2-0.5-1.1-0.3-0.9-0.1-0.9-1.8-1.6-1.4-1.5-1.4
Patch foraging water rate 24 sec0.30.41.6-0.1-0.3-0.1-0.4-0.6-0.50.0-1.0-0.2-1.1-0.6-1.3
Patch foraging water rate 6 sec0.60.92.8-0.40.2-1.5-0.0-0.90.2-0.5-1.4-1.7-1.0-1.1-0.8
Seeking ratio, delayed vs. immediate footshock0.30.41.1-0.20.10.70.20.10.30.41.01.00.70.70.7
Distance traveled before self-admin0.91.13.01.3-0.9-0.5-1.0-0.8-1.7-0.5-1.5-1.3-1.1-0.9-0.4
Distance traveled after self-admin0.20.20.50.6-0.70.4-0.3-0.0-0.70.0-0.50.2-0.1-0.3-0.6
Extensor digitorum longus weight1.66.216.92.5-0.94.1-0.8-1.6-0.91.62.53.81.42.34.1
Bone: elastic displacement2.42.85.81.0-1.9-0.0-1.7-1.6-1.5-1.8-1.8-1.6-2.4-2.1-1.2
Bone: elastic work1.21.54.1-0.6-1.0-1.2-0.4-0.5-0.6-1.0-1.0-2.0-1.7-1.7-1.7
Bone: endosteal estimation7.716.933.7-5.85.6-4.95.35.52.34.13.1-0.53.43.0-1.6
Bone: endosteal perimeter8.217.437.6-6.15.8-4.95.64.82.25.22.9-0.83.12.3-1.4
Epididymis fat weight0.31.02.7-1.21.4-0.81.20.30.81.61.00.50.71.10.8
Delta time in closed arm before/after self-admin0.80.71.50.2-0.7-0.4-0.7-0.1-0.9-0.7-0.9-1.2-1.2-1.1-1.1
Delta time in open arm before/after self-admin2.02.06.20.30.61.40.6-0.11.70.81.22.51.71.62.2
Diff in mean of infusions in LGA sessions0.91.13.21.8-1.01.8-1.2-0.7-0.0-1.40.01.00.10.30.6
Delay discount exponential model param0.40.40.90.7-0.60.9-0.50.7-0.5-0.90.70.70.20.4-0.1
Extinction: sum of active levers before priming1.11.23.30.40.50.90.60.11.60.50.91.81.41.41.4
Active lever presses in extinction session 61.31.32.6-0.91.6-1.21.51.30.80.81.20.11.41.50.4
Bone: final force1.32.15.8-1.20.1-2.30.1-0.7-0.5-0.1-1.8-2.4-1.5-2.0-1.7
Bone: final moment1.52.47.0-1.20.1-2.50.1-0.6-0.6-0.3-1.9-2.6-1.6-2.0-1.9
Food consumed during 24 hour testing period2.33.25.7-2.42.2-0.72.41.41.92.32.11.31.31.60.1
Glucose0.91.43.61.5-1.50.9-1.6-1.4-1.9-0.3-1.00.2-1.2-0.90.3
Heart weight0.81.33.9-0.2-0.6-0.4-0.4-2.0-1.00.7-1.6-1.0-1.8-1.6-0.2
Delay discount hyperbolic model param0.40.40.80.7-0.60.9-0.50.7-0.4-0.90.80.80.30.50.1
Intermittent access intake day 1-15 change0.20.51.40.3-0.00.6-0.20.8-1.00.41.11.20.50.80.2
Intermittent access intake escalation0.30.61.7-0.20.50.20.31.0-0.70.91.31.20.81.00.2
Intermittent access intake escalation 20.70.82.1-0.40.50.10.51.3-0.70.91.51.00.91.10.1
Intermitt. access day 1 inactive lever presses0.72.75.0-2.12.2-2.02.22.21.50.71.6-0.31.61.4-0.2
Intermitt. access day 15 inactive lever presses1.12.34.5-1.42.1-2.01.31.70.80.21.7-0.71.82.01.0
Intermitt. access escalation Index1.31.94.52.1-1.51.3-1.7-1.6-2.1-0.7-1.50.1-1.1-0.80.2
Intermittent access day 1 total infusions0.40.71.8-1.41.2-0.90.90.31.20.60.0-0.1-0.1-0.3-1.0
Intermittent access day 15 total infusions1.01.54.3-1.71.8-0.51.40.80.72.11.41.10.60.7-0.0
Intermittent access terminal intake (last 3 days)1.82.35.4-2.32.2-0.81.71.41.12.31.71.11.00.9-0.2
Intermittent access total infusions1.72.05.5-2.32.1-0.71.61.01.72.01.11.00.50.2-0.7
Intermittent access day 1 locomotion2.12.67.8-2.82.2-2.12.01.41.51.20.9-0.90.1-0.2-1.7
Intermittent access day 15 total locomotion2.34.211.1-3.33.0-1.22.62.02.22.32.00.90.90.3-1.4
Intermittent access total locomotion4.25.115.4-3.93.2-2.12.72.22.72.01.80.10.80.3-1.8
Intermittent access standard deviation0.40.81.8-1.41.0-0.30.91.20.80.51.20.80.1-0.0-1.1
Left kidney weight0.52.26.0-0.0-1.1-0.8-0.9-1.7-0.5-0.8-2.3-1.7-1.9-2.4-1.5
Right kidney weight0.73.010.1-0.8-0.6-1.2-0.5-1.6-0.5-0.3-2.4-1.9-2.4-3.2-2.1
Cocaine induced anxiety1.31.93.60.4-1.0-0.7-1.0-1.0-1.3-1.3-1.6-1.9-1.9-1.8-1.7
Post-drug Anxiety2.02.25.00.4-1.1-0.5-1.0-1.2-1.5-1.1-1.6-1.7-2.2-2.1-1.9
Baseline Anxiety0.00.00.10.2-0.10.3-0.1-0.4-0.20.00.10.1-0.3-0.20.1
Tail length1.45.415.9-4.02.7-3.52.72.32.41.51.1-1.70.90.3-1.9
Length with tail1.04.315.4-3.92.3-2.72.61.81.42.70.6-0.90.3-0.7-1.9
Length without tail0.20.52.2-1.20.2-0.40.50.2-0.41.5-0.10.0-0.6-1.0-0.8
Times rat made contact with spout0.50.62.5-1.60.8-0.70.90.90.30.60.5-0.3-0.1-0.2-1.0
Lifetime Intake1.92.35.7-2.42.4-1.01.81.01.91.91.20.80.80.5-0.4
Liver weight, left2.13.49.3-3.11.8-2.42.22.41.20.90.3-1.40.1-0.8-2.6
Liver weight, right2.13.76.80.2-1.8-0.9-1.6-1.7-1.0-2.0-2.6-2.5-2.3-2.6-2.0
Locomotor activity0.40.61.6-0.91.2-0.20.60.81.3-0.00.71.00.50.4-0.8
Locomotor testing distance0.71.33.1-1.21.8-0.61.01.41.20.21.40.71.11.4-0.3
Locomotor testing rearing1.32.77.0-0.91.70.11.02.60.8-0.12.61.52.02.6-0.3
Locomotion in novel chamber1.92.57.1-0.3-1.2-0.7-1.2-0.2-2.2-0.3-1.4-1.8-2.2-2.1-2.7
Locomotion in novel chamber post-restriction0.71.13.8-1.21.7-1.51.2-0.00.41.9-0.6-0.6-0.0-0.8-0.6
Fecal boli incidents, locomotor time 10.30.42.10.60.30.00.00.1-0.61.00.30.40.90.71.5
Change in fecal boli incidents, locomotor task0.20.20.6-0.4-0.50.1-0.2-0.80.00.5-0.2-0.2-0.3-0.30.8
Time >=10cm from walls, locomotor time 12.12.24.41.9-2.11.6-1.8-1.2-2.0-1.1-1.40.3-1.5-0.9-0.7
Bouts of movement, locomotor time 10.10.10.30.4-0.60.2-0.1-0.50.1-0.60.1-0.20.00.20.6
Total resting periods, locomotor time 10.10.10.40.4-0.70.1-0.3-0.6-0.1-0.5-0.1-0.4-0.2-0.10.5
Rest time, locomotor task time 10.10.20.80.5-0.1-0.2-0.20.0-0.3-0.4-0.2-0.50.50.30.9
Distance moved, locomotor task time 10.30.41.6-1.10.2-0.40.40.30.40.50.4-0.2-0.8-0.3-1.3
Vertical activity count, locomotor time 10.20.51.7-0.9-0.0-0.70.20.1-0.10.3-0.3-0.9-1.0-0.5-1.3
Time >=10cm from walls, locomotor time 20.60.92.60.6-0.6-0.3-1.00.5-1.6-1.1-0.5-0.7-1.1-0.6-1.6
Bouts of movement, locomotor time 20.30.52.60.9-0.80.4-0.1-0.5-0.3-0.20.3-0.00.61.11.6
Total resting periods, locomotor time 20.40.72.71.2-1.20.5-0.3-0.7-0.5-0.40.1-0.10.41.01.6
Rest time, locomotor task time 21.72.26.92.6-1.81.5-1.0-1.9-1.4-0.6-1.20.30.0-0.02.2
Distance moved, locomotor task time 20.91.06.0-1.20.3-0.70.21.40.2-0.70.7-0.7-0.8-0.6-2.4
Vertical activity count, locomotor time 21.31.74.8-1.91.3-1.61.12.21.3-0.21.4-0.70.60.7-1.4
Light reinforcement 10.81.98.7-0.31.1-0.31.6-0.62.90.40.30.51.80.92.3
Light reinforcement 20.81.24.4-0.60.9-1.11.1-0.52.10.3-0.2-0.51.20.42.1
Bone: marrow area7.416.232.9-5.75.5-4.85.25.42.24.03.0-0.63.22.9-1.7
Bone: maximum diameter2.24.213.9-3.22.7-3.72.41.40.62.1-0.1-2.30.5-0.1-1.0
Bone: maximum force1.32.37.5-2.20.7-2.70.8-0.70.01.1-1.5-2.3-1.2-1.4-1.5
Bone: maximum moment1.42.58.2-2.20.7-2.90.7-0.6-0.00.8-1.5-2.5-1.3-1.5-1.6
Mean time between licks in bursts0.20.43.0-0.50.7-0.20.2-0.6-0.71.70.00.1-0.3-0.30.5
Mean num. licks in bursts0.20.31.2-1.10.4-0.30.70.40.80.50.80.00.20.70.1
Cd content in liver2.02.28.72.2-1.92.9-1.5-0.7-0.9-0.60.51.9-0.00.11.2
Co content in liver0.91.15.11.6-0.72.3-0.9-0.3-0.4-0.40.51.7-0.0-0.40.7
Cu content in liver0.30.40.9-0.40.5-0.50.90.90.80.30.7-0.40.90.60.2
Fe content in liver0.20.30.80.4-0.90.4-0.40.70.0-0.9-0.3-0.1-0.1-0.2-0.6
K content in liver0.20.21.1-0.40.40.10.60.41.10.4-0.30.30.5-0.3-0.0
Mg content in liver0.60.62.00.9-0.51.4-0.1-0.11.4-0.7-0.11.00.7-0.20.9
Mn content in liver0.80.92.90.4-0.4-0.0-0.4-0.61.2-1.4-1.7-0.6-0.6-1.5-1.1
Na content in liver0.60.62.5-0.10.70.21.01.11.60.00.50.71.20.30.2
Rb content in liver2.53.06.82.3-2.62.0-2.1-1.5-0.9-2.1-1.80.0-1.3-1.7-0.3
Se content in liver0.81.02.51.2-1.11.5-0.6-1.60.5-0.1-1.00.8-0.2-0.71.3
Sr content in liver0.40.41.2-0.70.9-1.10.90.30.20.60.2-0.6-0.0-0.4-0.3
Zn content in liver0.40.51.00.7-1.00.2-0.7-0.9-0.5-0.4-1.0-0.5-0.7-0.8-0.0
Bone: minimum diameter6.511.828.9-5.44.6-4.84.63.32.24.12.0-1.51.81.3-1.4
Time in familiar zone, hab. session 11.61.62.9-0.61.10.61.01.00.51.71.61.71.61.61.1
Time in novel zone, hab. session 11.61.63.41.1-1.3-0.6-1.3-1.2-1.0-1.8-1.4-1.8-1.5-1.2-0.5
Total zone transitions, hab. session 10.20.31.8-0.80.3-0.00.0-0.30.60.4-0.00.5-0.5-0.6-1.3
Total locomotion distance, hab. session 11.01.46.6-1.70.5-1.60.4-0.00.9-0.2-0.6-1.2-0.9-0.9-2.6
Locomotion velocity, hab. session 11.11.56.9-2.00.9-1.50.60.21.10.2-0.4-0.8-0.7-0.8-2.6
Time in familiar zone, hab. session 21.71.73.8-0.81.40.61.01.60.71.42.01.81.51.40.8
Time in novel zone, hab. session 22.42.45.80.7-1.2-1.1-1.2-1.8-0.9-1.5-2.4-2.4-1.8-1.5-1.0
Total zone transitions, hab. session 20.30.31.8-0.50.50.70.10.11.00.30.41.30.2-0.2-0.2
Total locomotion distance, hab. session 20.60.74.3-1.31.1-0.10.60.02.10.40.40.60.40.1-0.1
Locomotion velocity, hab. session 20.50.63.9-1.40.9-0.10.5-0.22.00.50.20.60.2-0.1-0.2
Novel to familiar place preference ratio0.20.21.0-0.40.1-0.90.5-0.10.10.5-0.2-1.0-0.3-0.2-0.1
Novelty place preference0.10.10.8-0.1-0.1-0.70.3-0.1-0.10.1-0.3-0.9-0.3-0.3-0.0
Time in novel zone, NPP test0.20.21.1-0.1-0.2-0.70.1-0.2-0.2-0.1-0.4-1.1-0.5-0.4-0.3
Total zone transitions, NPP test0.40.61.7-0.80.30.1-0.2-0.91.30.1-0.80.5-0.7-1.0-1.0
Total locomotion distance, NPP test0.81.14.3-1.80.9-1.10.3-0.01.5-0.1-0.5-0.3-0.6-0.6-2.1
Locomotion velocity, NPP test0.50.73.0-1.61.0-0.70.5-0.51.70.5-0.20.2-0.2-0.2-1.0
Intraocular pressure0.91.33.3-0.91.6-0.90.9-0.30.41.81.10.21.01.81.5
Delta distance traveled before/after self-admin0.30.31.20.1-0.31.10.30.30.8-0.40.61.10.60.3-0.2
Delta ambulatory time before/after self-admin0.30.30.9-0.3-0.10.70.40.40.90.20.60.90.70.50.1
Parametrial fat weight0.61.44.0-1.1-0.0-1.90.4-0.1-0.50.1-1.3-2.0-1.0-1.9-1.1
Pavlov. Cond. lever latency1.11.33.31.8-0.71.7-1.2-1.4-1.10.3-0.21.20.20.41.7
Pavlov. Cond. magazine entry latency2.12.75.9-2.41.9-2.32.22.12.10.40.8-1.20.90.0-1.0
Pavlov. Cond. change in total contacts1.71.84.4-1.61.2-1.81.72.11.8-0.21.0-1.00.90.5-0.7
Pavlov. Cond. index score1.72.14.9-2.21.5-2.02.01.91.90.20.7-1.20.60.0-1.0
Pavlov. Cond. latency score1.41.74.1-2.01.3-1.71.81.71.70.20.6-0.90.5-0.1-1.1
Pavlov. Cond. lever contacts1.31.63.8-1.90.9-1.71.42.01.1-0.20.6-1.20.2-0.1-1.6
Pavlov. Cond. magazine entry number1.62.04.51.9-1.61.8-1.9-1.9-2.1-0.1-0.81.1-1.0-0.30.4
Pavlov. Cond. intertrial magazine entries2.02.44.7-0.81.70.11.40.11.92.21.31.52.02.11.8
Pavlov. Cond. lever-magazine prob. diff.1.72.14.9-2.21.4-2.21.91.81.70.20.5-1.50.5-0.1-1.0
Pavlov. Cond. response bias2.73.38.5-2.71.5-2.92.12.21.9-0.20.2-2.20.4-0.4-1.7
Pavlov. Cond. lever latency0.20.20.60.8-0.60.6-0.6-0.6-0.6-0.2-0.10.3-0.4-0.00.3
Pavlov. Cond. magazine entry latency1.72.14.51.9-2.11.8-1.9-1.3-1.9-0.8-1.20.3-1.1-1.00.2
Pavlov. Cond. change in total contacts0.50.81.6-0.40.80.40.91.31.20.61.01.01.20.90.3
Pavlov. Cond. index score0.00.10.10.2-0.30.2-0.20.3-0.4-0.1-0.2-0.0-0.0-0.2-0.3
Pavlov. Cond. latency score0.20.20.60.3-0.60.2-0.50.1-0.7-0.4-0.6-0.3-0.4-0.6-0.5
Pavlov. Cond. lever contacts0.10.20.6-0.60.5-0.40.60.50.80.20.2-0.10.50.2-0.0
Pavlov. Cond. magazine entry number2.43.05.9-2.12.4-1.72.41.52.11.51.7-0.01.71.40.5
Pavlov. Cond. intertrial magazine entries7.711.523.4-4.54.8-3.74.73.23.43.63.1-0.33.02.30.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.3-0.50.3-0.30.1-0.5-0.2-0.4-0.1-0.2-0.4-0.3
Pavlov. Cond. response bias0.00.00.1-0.1-0.10.10.00.10.20.0-0.20.00.1-0.1-0.2
Time in closed arm before self-admin0.20.31.8-0.0-0.2-0.10.30.2-0.0-1.0-0.1-0.3-0.5-0.6-1.4
Time in closed arm after self-admin1.31.44.40.5-1.10.6-0.8-0.2-1.4-1.1-0.8-0.6-1.7-1.6-2.1
Time in open arm before self-admin2.12.36.31.1-1.3-0.2-1.9-1.1-2.5-0.7-1.7-1.6-1.9-1.8-1.1
Time in open arm after self-admin0.80.82.7-0.10.60.40.3-0.10.51.40.81.31.01.11.7
Bone: periosteal estimation4.49.225.1-4.83.9-5.03.93.21.62.71.0-2.31.40.8-1.7
Bone: periosteal perimeter2.44.213.3-3.12.2-3.62.41.50.22.1-0.1-2.3-0.1-0.7-1.9
Bone: post-yield work0.71.02.8-1.71.0-1.61.00.9-0.51.40.2-0.70.10.1-0.9
Progressive ratio test 1 active lever presses1.61.94.8-2.22.1-1.81.80.81.81.40.7-0.40.70.5-0.3
Progressive ratio test 1 breakpoint1.92.35.5-2.32.2-1.82.00.92.11.50.9-0.30.90.7-0.1
Progressive ratio test 1 inactive lever presses1.72.46.1-2.32.5-1.81.91.31.91.51.1-0.11.31.0-0.1
Progressive ratio test 2 active lever presses2.93.58.3-2.92.8-2.32.41.31.72.51.1-0.51.10.8-0.0
Progressive ratio test 2 breakpoint3.33.78.9-3.02.9-2.32.51.41.72.71.2-0.41.20.9-0.1
Progressive ratio test 2 inactive lever presses1.62.66.7-2.52.6-1.72.00.72.11.91.20.01.10.80.5
Incentive Sensitization - Responses1.42.05.7-2.22.1-1.61.91.10.62.40.8-0.30.90.7-0.0
Incentive Sensitization - Breakpoint1.52.05.7-2.22.1-1.61.81.20.52.40.9-0.20.80.6-0.2
Sum of active levers in priming session hrs 5-61.71.64.01.6-0.11.6-0.3-0.20.6-0.10.71.91.51.82.0
Progressive ratio0.10.21.0-0.30.5-0.00.8-0.30.21.0-0.40.1-0.1-0.3-0.1
Food seeking constrained by brief footshock2.93.67.6-2.12.6-0.52.22.81.11.62.41.82.01.7-0.5
Seeking ratio, punishment vs. effort1.01.43.7-1.21.3-0.70.81.90.70.41.80.81.41.50.0
Retroperitoneal fat weight0.31.34.4-2.11.4-1.41.50.71.21.00.7-0.40.40.2-0.6
Reaction time number correct0.61.24.00.3-0.9-0.1-0.7-2.0-0.80.1-1.9-0.6-1.4-1.4-0.5
Reaction time mean minus median0.10.20.60.6-0.50.2-0.70.0-0.8-0.50.1-0.20.00.30.3
Reaction time mean minus median AUC0.40.92.21.4-1.10.7-1.5-1.2-0.8-1.0-1.1-0.2-0.8-0.80.2
Reaction time num false alarms1.62.35.8-2.42.2-1.72.21.41.51.70.60.00.90.2-1.1
Reaction time num false alarms AUC1.72.66.8-2.62.3-1.82.41.41.81.70.6-0.10.90.0-1.2
Reaction time trials correct on left0.61.24.00.3-0.9-0.1-0.7-2.0-0.80.1-1.9-0.6-1.4-1.4-0.5
Reaction time trials on left0.71.24.10.2-0.8-0.2-0.7-2.0-0.80.1-2.0-0.7-1.4-1.5-0.5
Reaction time mean0.50.92.71.4-1.00.4-1.5-0.3-1.0-1.6-0.9-0.5-0.6-0.1-0.1
Reaction time mean AUC0.71.13.71.7-1.20.6-1.7-0.2-1.0-1.9-0.7-0.3-0.40.10.1
Median of all reaction times0.71.03.31.4-1.00.3-1.5-0.3-0.9-1.8-1.0-0.6-0.7-0.2-0.2
Reaction time omissions0.40.52.6-0.70.2-1.6-0.1-0.1-0.2-0.3-0.6-1.60.0-0.2-0.1
Reaction time false alarm rate2.02.75.3-2.32.2-1.52.32.31.61.21.50.21.30.9-0.9
Reaction time premature initiation rate0.81.22.3-1.01.5-0.91.40.41.50.80.9-0.31.30.91.1
Reaction time premature initiations0.40.61.4-0.91.1-0.81.1-0.61.21.0-0.0-0.30.70.00.9
Std. dev. reaction times0.20.31.00.8-0.80.3-1.0-0.0-0.8-1.0-0.3-0.4-0.20.00.1
Reaction time trials completed0.71.24.10.2-0.8-0.2-0.7-2.0-0.80.1-2.0-0.7-1.4-1.5-0.5
Reaction time trials AUC0.61.24.00.2-0.9-0.0-0.7-2.0-0.70.1-1.9-0.6-1.3-1.4-0.5
Run reversals in cocaine runway, females0.40.41.90.1-0.3-0.7-0.8-0.6-1.4-0.3-0.0-0.7-0.7-0.30.3
Run reversals in cocaine runway, males0.40.41.90.4-0.6-0.5-0.4-0.5-1.40.2-0.6-1.0-0.7-0.4-0.0
Latency to leave start box in cocaine runway0.20.20.60.7-0.60.1-0.7-0.4-0.8-0.4-0.3-0.4-0.4-0.10.1
Latency to leave start box in cocaine runway, F1.01.22.81.0-1.1-0.5-1.1-0.9-1.7-0.8-1.1-1.5-1.2-0.8-0.4
Latency to leave start box in cocaine runway, M0.70.61.7-0.00.50.90.40.90.8-0.01.01.31.10.90.6
Std. dev. time between licks in bursts0.10.10.40.1-0.10.40.0-0.10.20.40.60.60.20.50.6
Total sessions with >9 infusions0.20.30.9-0.70.8-0.20.3-0.41.00.60.40.40.10.20.3
Short access day 1 total inactive lever presses1.31.75.7-2.01.8-2.41.20.80.70.60.3-1.5-0.3-0.5-1.3
Short access day 10 total inactive lever presses0.20.52.2-0.30.8-0.80.4-0.00.40.30.6-0.10.80.91.5
Short access day 1 total infusions0.40.52.4-0.71.2-0.60.6-0.31.60.40.30.10.60.50.7
Short access day 10 total infusions1.72.25.6-2.22.4-1.31.71.21.91.41.40.51.11.0-0.1
Short access total infusions0.91.13.1-1.41.8-1.21.20.61.50.70.80.10.90.80.1
Short access day 1 locomotion1.31.63.2-1.71.8-1.61.20.01.71.50.9-0.50.81.01.1
Short access day 10 total locomotion2.75.010.6-3.33.1-1.92.92.72.41.62.60.31.61.2-1.1
Short access total locomotion1.82.15.4-2.32.2-1.61.81.21.81.31.6-0.20.80.8-0.3
One hour access (0.3 mA shock)0.60.71.7-1.01.1-0.90.90.80.31.30.70.10.91.00.4
Compulsive drug intake1.31.53.11.0-1.1-0.3-1.0-1.2-1.7-0.7-1.8-1.4-1.4-1.6-0.7
One hour access (shock baseline)1.11.72.5-1.51.5-0.31.21.31.41.51.61.21.31.40.4
Social response proportion0.30.31.50.2-0.80.5-0.5-0.7-1.20.7-0.20.3-0.60.0-0.1
Social responses0.10.10.6-0.1-0.10.40.10.20.20.40.50.70.30.4-0.3
Social time0.30.43.00.10.1-0.6-0.20.3-1.70.70.2-0.5-0.10.60.1
Soleus weight0.10.20.5-0.60.3-0.60.5-0.0-0.20.70.1-0.60.1-0.20.1
Bone: stiffness0.40.61.6-1.30.4-0.70.4-0.50.31.1-1.0-0.2-0.6-0.9-0.9
Tibialis anterior weight0.93.18.7-0.10.71.51.40.61.12.02.92.32.02.12.3
Time to tail flick, vehicle, before self-admin2.02.15.50.4-0.7-1.1-1.3-0.6-1.9-0.2-2.0-2.4-1.6-1.8-1.3
Time to tail flick, vehicle, after self-admin0.30.41.1-0.00.5-0.80.2-0.90.10.7-1.0-0.8-0.3-0.70.6
Time to tail flick, test, before self-admin0.30.30.70.6-0.20.6-0.30.8-0.8-0.60.70.50.30.6-0.2
Time to tail flick, test, after self-admin0.00.00.10.00.3-0.20.30.10.3-0.1-0.1-0.00.20.10.2
Delta time to tail flick, vehicle, before/after SA1.71.63.5-1.11.6-0.51.90.91.71.01.31.01.51.21.0
Delta time to tail flick, test, before/after SA0.10.10.5-0.10.1-0.00.2-0.50.60.3-0.70.2-0.2-0.6-0.1
Tibia length1.02.77.9-1.0-0.9-0.9-0.5-1.6-0.4-0.2-2.3-1.6-2.2-2.8-2.5
Ambulatory time before self-admin0.50.82.10.8-0.6-0.5-0.4-0.5-1.5-0.3-1.3-1.1-1.0-1.0-0.9
Ambulatory time after self-admin0.10.10.20.3-0.5-0.10.10.1-0.3-0.1-0.4-0.2-0.0-0.2-0.5
Bone: tissue strength1.71.73.30.7-1.50.9-1.6-1.8-1.0-0.6-1.8-0.4-1.8-1.5-1.0
Total heroin consumption0.30.31.4-0.20.5-0.80.31.10.3-0.5-0.2-0.50.20.2-1.2
Bone: trabecular number1.62.610.0-2.11.2-3.21.30.51.3-0.1-1.2-2.7-0.4-1.3-1.4
Bone: trabecular spacing1.11.55.91.1-0.12.3-0.40.3-0.50.61.42.40.71.31.0
Bone: trabecular thickness2.43.012.9-2.11.0-3.61.40.20.40.4-1.1-3.2-0.7-1.2-1.1
Bone: trabecular tissue density2.23.28.70.2-1.6-0.4-1.5-2.9-0.7-0.6-2.9-1.5-2.6-2.4-0.7
Water consumed over 24 hours0.20.31.2-0.9-0.1-0.40.2-0.00.3-0.1-0.2-0.5-0.8-0.4-1.1
Number of responses in last shaping day0.50.52.7-0.30.4-1.5-0.2-0.0-0.5-0.2-0.3-1.6-0.4-0.1-0.2