Hub : Genes

Ddx3y

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ddx3y	0.04	0.03	6.5e-06	0.04	0.03	0.03	0.04	2.1e-05	1.2e-04	2.3e-04	5.2e-05
2	Brain	gene expression	Ddx3y	0.13	0.07	1.1e-16	0.19	0.17	0.17	0.18	4.8e-17	4.5e-16	8.5e-16	4.0e-16
3	PL	gene expression	Ddx3y	0.14	0.07	0.0e+00	0.18	0.18	0.19	0.18	1.9e-19	1.4e-19	4.7e-20	6.4e-20
4	pVTA	gene expression	Ddx3y	0.18	0.14	2.2e-05	0.07	0.11	0.11	0.11	4.7e-04	1.3e-05	2.3e-05	2.0e-05
5	LHb	gene expression	Ddx3y	0.18	0.13	6.2e-03	0.06	0.06	0.03	0.04	2.0e-02	1.3e-02	8.0e-02	3.3e-02
6	Adipose	gene expression	Ddx3y	0.1	0.07	7.6e-09	0.05	0.05	0.05	0.06	5.7e-06	1.1e-06	4.2e-06	5.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	0.9	-0.2	-0.8	-0.2	0.9	0.0	0.8
Area under the delay curve	0.2	0.3	0.4	0.5	0.6	0.6	-0.4	-0.5	-0.3
BMI with tail	1.2	3.9	5.2	-2.3	-1.9	-2.0	1.8	1.8	2.0
BMI without tail	0.7	1.5	2.0	1.2	1.2	1.2	-1.4	-1.1	-1.3
Body weight	0.4	1.5	2.0	1.2	1.4	1.2	-1.2	-1.3	-1.1
Weight adjusted by age	0.6	0.7	1.4	1.0	0.9	0.9	-0.4	-1.2	-0.5
Bone surface	0.1	0.2	0.2	0.4	0.2	0.5	-0.4	-0.4	-0.4
Bone volume	0.1	0.2	0.2	0.4	0.2	0.5	-0.3	-0.5	-0.4
Breakpoint value in progressive ratio session	1.8	2.0	2.5	-1.5	-1.6	-1.3	1.2	1.5	1.3
Number of licking bursts	0.3	0.4	0.7	-0.4	-0.8	-0.6	0.6	0.7	0.6
Context. condit. distance diff. score	0.9	1.1	1.9	1.2	1.2	1.1	-0.6	-1.4	-0.5
Locomotion velocity, session 1	0.1	0.1	0.3	-0.3	-0.5	-0.4	0.1	0.5	-0.1
Locomotion distance, session 1	0.1	0.1	0.2	-0.4	0.0	-0.4	0.2	0.3	0.3
Locomotion velocity, session 2	0.0	0.0	0.1	-0.2	0.1	-0.1	0.3	-0.1	0.1
Locomotion distance, session 2	0.1	0.1	0.3	0.1	0.2	0.2	-0.5	-0.0	-0.5
Locomotion velocity, session 3	5.5	6.4	8.1	2.7	2.3	2.5	-2.9	-2.1	-2.8
Locomotion distance, session 3	6.2	6.8	8.2	2.9	2.5	2.6	-2.8	-2.2	-2.6
Stereotopy head waving bouts, day 3	1.3	1.5	2.3	-1.4	-1.2	-1.4	0.7	1.5	0.8
Stereotopy head waving duration, day 3	0.9	1.1	1.6	-1.2	-1.0	-1.2	0.6	1.2	0.7
Locomotion velocity, session 7	2.2	2.4	4.3	1.5	1.2	1.3	-2.0	-0.8	-2.1
Locomotion distance, session 7	1.7	2.2	2.7	1.6	1.2	1.4	-1.6	-1.3	-1.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.5	-0.4	-0.1	-0.4	-0.2	0.7	-0.0
Stereotopy head waving duration, day 7	0.4	0.5	1.0	-0.8	-0.5	-0.7	0.3	1.0	0.5
Locomotion velocity, session 8	0.1	0.1	0.2	-0.4	-0.1	-0.3	0.4	0.3	0.4
Locomotion distance, session 8	0.9	1.3	1.6	1.2	1.3	1.2	-0.9	-1.2	-0.9
Degree of sensitization distance	2.0	2.0	2.6	-1.5	-1.5	-1.4	1.6	1.0	1.4
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.3	-0.0	-0.2	-0.2	0.5	0.0
Conditioned locomotion	3.1	3.6	3.8	-2.0	-1.8	-1.9	1.9	1.9	1.9
Cocaine response after cond. corrected	0.2	0.3	0.6	-0.5	-0.4	-0.5	0.8	0.2	0.5
Cocaine response after cond. not corrected	0.4	0.4	0.8	-0.6	-0.5	-0.6	0.9	0.3	0.7
Cocaine response before conditioning	0.0	0.0	0.0	0.1	-0.0	0.1	-0.1	0.0	0.1
Saline control response	0.2	0.3	0.8	0.4	0.9	0.5	0.1	-0.8	0.2
Bone: connectivity density	0.1	0.2	0.5	-0.0	-0.3	0.0	0.7	-0.3	0.6
Bone: cortical apparent density	1.1	1.4	1.6	1.3	1.2	1.2	-1.1	-1.2	-1.1
Bone: cortical area	0.3	0.5	1.1	0.5	0.6	0.6	-1.0	-0.3	-0.9
Bone: cortical porosity	0.3	0.4	1.0	-0.2	-0.2	-0.3	1.0	-0.1	1.0
Bone: cortical porosity	0.2	0.2	0.3	0.2	0.4	0.2	0.5	-0.6	0.6
Bone: cortical thickness	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.4	0.3	-0.2
Bone: cortical thickness	0.2	0.3	0.6	0.3	0.3	0.4	-0.7	-0.2	-0.7
Bone: cortical tissue density	1.1	1.5	1.7	1.3	1.3	1.2	-1.1	-1.3	-1.1
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	0.6	0.7	0.7	-0.3	-0.9	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.8	0.5	0.4	0.4	0.2	-0.9	0.1
Condit. Reinf. active responses	1.1	1.4	2.0	1.1	1.4	1.2	-1.0	-1.4	-0.9
Condit. Reinf. inactive responses	0.6	0.7	1.2	0.6	1.1	0.7	-1.0	-0.6	-0.9
Incentive salience index mean	0.9	1.1	1.8	1.0	1.3	1.1	-0.7	-1.3	-0.7
Condit. Reinf. lever presses	0.7	0.9	2.0	0.8	1.4	0.9	-0.8	-1.1	-0.7
Condit. Reinf. active minus inactive responses	0.6	0.8	1.3	-0.6	-1.0	-0.7	1.1	0.5	1.1
Condit. Reinf. active-inactive response ratio	3.5	3.7	4.6	-1.8	-2.1	-1.9	1.9	1.9	1.9
Condit. Reinf. active responses	0.1	0.1	0.2	0.3	-0.1	0.3	0.2	-0.4	0.2
Condit. Reinf. inactive responses	3.8	4.7	5.6	2.2	2.4	2.3	-1.8	-2.4	-1.8
Condit. Reinf. lever presses	1.4	1.9	2.4	1.6	1.2	1.5	-1.6	-1.2	-1.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	0.5	0.0	0.4	-0.0	-0.5	0.0
Conditioned reinforcement - actives	4.5	4.5	5.5	-2.1	-2.0	-2.1	2.3	2.0	2.2
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.2	-0.2	-0.1	-0.2	0.2	-0.1
Conditioned locomotion	0.8	0.9	1.2	-0.8	-1.0	-1.0	1.1	1.0	0.9
Patch foraging indifference point 0 sec	0.3	0.5	0.9	-0.6	-0.9	-0.5	0.7	0.5	0.9
Patch foraging indifference point AUC	0.1	0.1	0.3	0.4	-0.1	0.3	-0.5	-0.1	-0.6
Delay disc. indifference point, 0s delay	0.0	0.0	0.2	-0.1	-0.0	-0.0	-0.2	0.4	-0.0
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.2	0.3	0.4	0.2	-0.6	0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.5	0.4	0.4	-0.2	-0.3	-0.1
Delay disc. indifference point, 24s delay	2.0	1.9	3.0	1.3	1.5	1.5	-1.0	-1.7	-1.1
Delay disc. indifference point, 4s delay	0.6	0.7	1.0	1.0	0.9	0.9	-0.5	-1.0	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.2	0.5	0.4
Indifference point function ln k	0.6	0.8	0.9	-0.9	-0.9	-0.9	0.9	0.9	0.9
Indifference point function log k	0.6	0.8	0.9	-0.9	-0.9	-0.9	0.9	0.9	0.9
Patch foraging total patch changes 0 sec	0.3	0.5	1.0	-0.5	-1.0	-0.5	0.7	0.5	1.0
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.4	0.0	0.4	-0.5	-0.1	-0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.5	0.0	-0.7	0.0	-0.1	0.3	0.0
Patch foraging total patch changes 24 sec	1.3	1.6	2.0	1.4	0.9	1.4	-1.3	-1.2	-1.3
Patch foraging total patch changes 6 sec	1.5	2.2	2.8	1.7	1.2	1.6	-1.5	-1.4	-1.5
Patch foraging time to switch 0 sec	0.1	0.1	0.4	0.2	0.6	0.2	-0.1	-0.3	-0.1
Patch foraging water rate 0 sec	0.5	0.8	1.9	-0.7	-1.4	-0.6	0.8	0.7	0.8
Patch foraging water rate 12 sec	0.1	0.2	0.5	-0.1	-0.7	-0.3	-0.1	0.7	-0.1
Patch foraging water rate 18 sec	0.2	0.2	0.7	0.2	-0.1	0.2	-0.8	0.4	-0.6
Patch foraging water rate 24 sec	0.9	1.2	1.9	-1.0	-1.4	-1.1	0.8	1.4	0.9
Patch foraging water rate 6 sec	0.0	0.0	0.2	0.1	-0.4	0.0	-0.1	0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	0.0	-0.2	-0.1	0.5	0.1	0.5
Distance traveled before self-admin	0.8	0.8	1.6	1.0	0.8	1.0	-0.8	-1.3	-0.4
Distance traveled after self-admin	0.1	0.1	0.3	-0.1	-0.1	-0.1	-0.5	0.2	-0.4
Extensor digitorum longus weight	0.6	2.2	2.4	1.6	1.5	1.5	-1.4	-1.5	-1.5
Bone: elastic displacement	1.2	1.3	1.5	-1.2	-1.0	-1.2	1.1	1.1	1.2
Bone: elastic work	0.8	1.0	1.3	-1.1	-0.9	-1.1	0.9	0.9	1.0
Bone: endosteal estimation	0.1	0.1	0.4	0.1	-0.0	0.1	-0.6	0.1	-0.6
Bone: endosteal perimeter	0.8	1.7	2.4	1.1	1.0	1.3	-1.5	-1.1	-1.6
Epididymis fat weight	0.2	0.6	0.9	-0.9	-0.6	-0.8	0.8	0.7	0.7
Delta time in closed arm before/after self-admin	0.4	0.4	0.8	-0.8	-0.9	-0.6	0.4	0.6	0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.3	0.6	0.2	0.0	-0.3	-0.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.4	-0.4	-0.6	-0.2	0.0	0.4	-0.0
Delay discount exponential model param	0.2	0.2	0.3	-0.5	-0.6	-0.6	0.3	0.5	0.2
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.3	-0.3	-0.2	-0.0	0.5	0.1
Active lever presses in extinction session 6	1.5	1.4	2.3	-1.5	-1.0	-1.2	0.9	1.4	1.0
Bone: final force	0.8	1.3	2.1	-1.4	-1.2	-1.3	0.5	1.5	0.7
Bone: final moment	0.7	1.2	1.8	-1.3	-1.2	-1.2	0.5	1.4	0.6
Food consumed during 24 hour testing period	0.7	0.9	1.8	-0.9	-1.2	-0.9	0.4	1.4	0.6
Glucose	1.8	2.7	4.1	-1.4	-1.9	-1.4	2.0	1.1	1.8
Heart weight	2.8	3.9	5.7	1.9	1.8	1.8	-2.3	-1.5	-2.4
Delay discount hyperbolic model param	0.3	0.3	0.4	-0.6	-0.6	-0.7	0.4	0.5	0.2
Intermittent access intake day 1-15 change	1.7	1.7	2.0	-1.4	-1.3	-1.3	1.4	1.1	1.3
Intermittent access intake escalation	1.1	1.1	1.5	-1.2	-1.0	-1.0	1.0	0.8	1.0
Intermittent access intake escalation 2	2.0	2.0	2.4	-1.5	-1.4	-1.4	1.4	1.3	1.4
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.1	0.1	0.3	0.2	-0.4	-0.1	-0.3
Intermitt. access day 15 inactive lever presses	2.2	2.4	2.6	1.5	1.6	1.6	-1.4	-1.6	-1.5
Intermitt. access escalation Index	0.4	0.3	0.7	0.4	0.4	0.4	-0.9	-0.3	-0.8
Intermittent access day 1 total infusions	0.0	0.1	0.1	-0.0	0.2	-0.0	-0.3	0.3	-0.2
Intermittent access day 15 total infusions	0.9	1.0	1.5	-1.2	-1.0	-1.0	0.8	1.1	0.8
Intermittent access terminal intake (last 3 days)	1.3	1.5	2.3	-1.4	-1.3	-1.3	0.7	1.5	0.8
Intermittent access total infusions	0.6	0.7	0.9	-0.9	-0.8	-0.8	0.7	1.0	0.7
Intermittent access day 1 locomotion	0.1	0.1	0.6	-0.2	0.0	-0.3	-0.3	0.8	-0.3
Intermittent access day 15 total locomotion	2.2	2.3	2.6	-1.6	-1.4	-1.6	1.6	1.5	1.4
Intermittent access total locomotion	0.1	0.1	0.2	-0.3	0.1	-0.3	0.1	0.4	0.1
Intermittent access standard deviation	0.7	0.7	1.1	-0.9	-1.1	-0.9	0.5	1.1	0.5
Left kidney weight	3.5	9.8	12.2	3.0	3.3	3.0	-3.5	-2.6	-3.3
Right kidney weight	1.2	3.4	4.4	1.8	1.9	1.6	-2.1	-1.5	-2.0
Cocaine induced anxiety	7.0	8.1	9.7	3.1	2.8	2.8	-2.8	-2.6	-2.8
Post-drug Anxiety	3.1	3.4	4.1	2.0	1.9	1.7	-1.9	-1.5	-2.0
Baseline Anxiety	4.7	5.0	5.4	-2.3	-2.2	-2.3	2.1	2.3	2.1
Tail length	7.7	23.3	26.9	5.2	4.6	4.9	-4.8	-4.6	-4.8
Length with tail	3.9	14.1	16.5	4.1	3.8	3.8	-3.5	-3.7	-3.6
Length without tail	0.2	0.3	0.5	-0.6	-0.2	-0.6	0.7	0.4	0.7
Times rat made contact with spout	0.0	0.0	0.0	0.2	0.0	0.1	0.2	-0.2	0.1
Lifetime Intake	0.4	0.4	0.6	-0.7	-0.6	-0.7	0.6	0.7	0.6
Liver weight, left	0.1	0.1	0.2	0.1	0.3	0.0	0.4	-0.3	0.4
Liver weight, right	0.9	1.5	2.1	-1.3	-0.8	-1.3	1.3	1.1	1.5
Locomotor activity	1.6	2.5	4.7	-1.7	-1.8	-1.6	1.0	2.2	0.8
Locomotor testing distance	0.1	0.2	0.7	-0.4	-0.5	-0.4	-0.1	0.8	-0.2
Locomotor testing rearing	0.8	1.3	1.5	-1.1	-1.1	-1.1	1.2	1.2	1.0
Locomotion in novel chamber	0.7	0.9	1.7	-1.3	-0.7	-1.1	0.4	1.2	0.5
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	-0.1	0.3	-0.1	0.4	-0.2	0.3
Fecal boli incidents, locomotor time 1	0.8	0.9	1.5	-1.1	-0.6	-0.9	1.2	0.4	1.2
Change in fecal boli incidents, locomotor task	0.7	0.7	1.1	-1.0	-0.8	-1.0	0.6	1.0	0.6
Time >=10cm from walls, locomotor time 1	2.0	2.0	3.0	-1.5	-1.7	-1.4	1.2	1.5	1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.6	0.2	0.8	0.2	-0.2	-0.2	-0.1
Total resting periods, locomotor time 1	0.1	0.1	0.6	0.1	0.8	0.1	-0.1	-0.1	-0.0
Rest time, locomotor task time 1	0.4	0.5	1.1	-0.6	-0.1	-0.9	0.6	1.0	0.6
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.1	-0.5	-0.2	-0.1	0.3	0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.4	-0.3	-0.4	-0.4	0.5	0.2	0.7
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	-0.4	-0.4	-0.5	0.1	0.6	0.2
Bouts of movement, locomotor time 2	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	-0.0
Rest time, locomotor task time 2	0.8	0.9	2.1	-1.0	-0.4	-1.3	0.7	1.5	0.6
Distance moved, locomotor task time 2	0.0	0.1	0.2	0.4	-0.2	0.2	-0.1	-0.1	0.1
Vertical activity count, locomotor time 2	1.0	1.1	1.9	-0.7	-1.1	-0.9	1.1	0.9	1.4
Light reinforcement 1	0.1	0.2	0.7	-0.2	-0.2	-0.2	0.7	0.1	0.9
Light reinforcement 2	0.1	0.1	0.3	0.1	0.2	0.1	-0.6	0.2	-0.3
Bone: marrow area	0.0	0.1	0.3	-0.0	-0.1	0.0	-0.5	0.2	-0.5
Bone: maximum diameter	1.0	1.9	3.2	1.1	1.2	1.2	-1.8	-1.0	-1.7
Bone: maximum force	0.8	1.4	2.0	-1.3	-1.2	-1.3	0.7	1.4	0.9
Bone: maximum moment	0.6	1.1	1.6	-1.2	-1.1	-1.2	0.6	1.2	0.8
Mean time between licks in bursts	0.2	0.3	0.8	0.3	0.4	0.2	-0.9	0.2	-0.8
Mean num. licks in bursts	0.4	0.4	0.6	0.6	0.8	0.7	-0.5	-0.8	-0.5
Cd content in liver	1.0	1.1	1.7	1.1	0.6	1.2	-0.8	-1.3	-1.0
Co content in liver	2.0	2.3	2.5	-1.5	-1.5	-1.5	1.6	1.5	1.5
Cu content in liver	1.0	1.3	1.5	-1.1	-0.9	-1.1	1.2	1.1	1.2
Fe content in liver	0.2	0.2	0.4	0.6	0.4	0.6	-0.3	-0.6	-0.4
K content in liver	0.2	0.2	0.4	0.1	0.7	0.2	-0.6	0.0	-0.3
Mg content in liver	0.9	0.9	1.5	0.9	1.2	0.9	-0.9	-0.9	-0.8
Mn content in liver	0.3	0.3	0.4	0.6	0.7	0.6	-0.4	-0.6	-0.4
Na content in liver	0.5	0.5	1.0	-0.8	-0.6	-0.8	0.4	1.0	0.7
Rb content in liver	0.0	0.0	0.1	0.1	0.2	0.1	0.1	-0.3	-0.0
Se content in liver	0.3	0.4	0.9	0.5	0.7	0.6	-0.9	-0.3	-0.7
Sr content in liver	5.8	5.3	5.6	2.3	2.3	2.3	-2.3	-2.2	-2.4
Zn content in liver	0.5	0.5	0.8	0.8	0.8	0.8	-0.4	-0.9	-0.5
Bone: minimum diameter	1.3	2.5	3.2	1.4	1.6	1.5	-1.8	-1.4	-1.7
Time in familiar zone, hab. session 1	0.3	0.3	0.7	0.5	0.4	0.5	-0.7	-0.2	-0.8
Time in novel zone, hab. session 1	0.5	0.5	0.8	0.7	0.5	0.7	-0.9	-0.5	-0.8
Total zone transitions, hab. session 1	2.5	3.5	4.4	1.7	2.0	1.8	-2.1	-1.6	-2.0
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.4	0.7	0.4	-0.8	-0.3	-0.6
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.0	0.3	0.0	-0.1	-0.1	0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.5	0.4	0.3
Time in novel zone, hab. session 2	0.9	0.9	1.3	0.9	0.8	1.0	-1.1	-0.8	-1.0
Total zone transitions, hab. session 2	0.0	0.1	0.1	0.2	0.3	0.2	-0.3	-0.1	-0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.2	0.3	0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.2	-0.3	-0.2	-0.3	0.3	0.3	0.4
Novel to familiar place preference ratio	0.1	0.1	0.5	0.3	0.2	0.4	0.1	-0.7	-0.0
Novelty place preference	0.1	0.1	0.3	0.3	0.1	0.4	0.0	-0.6	-0.1
Time in novel zone, NPP test	0.3	0.3	0.6	0.5	0.3	0.6	-0.3	-0.8	-0.4
Total zone transitions, NPP test	0.9	1.2	2.0	1.0	1.4	1.1	-1.1	-1.0	-1.0
Total locomotion distance, NPP test	0.4	0.5	1.0	0.6	1.0	0.6	-0.7	-0.7	-0.5
Locomotion velocity, NPP test	0.2	0.2	0.6	0.4	0.7	0.4	-0.3	-0.6	-0.1
Intraocular pressure	0.2	0.3	0.5	-0.6	-0.7	-0.4	0.7	0.2	0.5
Delta distance traveled before/after self-admin	0.1	0.1	0.4	-0.2	-0.1	-0.1	-0.5	0.3	-0.6
Delta ambulatory time before/after self-admin	0.4	0.4	0.6	-0.8	-0.7	-0.8	0.4	0.7	0.2
Parametrial fat weight	1.1	2.1	2.9	-1.6	-1.4	-1.6	1.3	1.7	1.2
Pavlov. Cond. lever latency	0.3	0.3	0.8	-0.5	-0.9	-0.6	0.3	0.8	0.1
Pavlov. Cond. magazine entry latency	1.8	2.3	3.3	1.4	1.8	1.4	-1.7	-1.4	-1.4
Pavlov. Cond. change in total contacts	2.0	2.1	2.8	1.5	1.7	1.5	-1.3	-1.6	-1.1
Pavlov. Cond. index score	0.4	0.5	1.2	0.6	1.1	0.7	-0.7	-0.7	-0.4
Pavlov. Cond. latency score	0.7	0.8	1.7	0.8	1.3	0.9	-0.9	-0.9	-0.6
Pavlov. Cond. lever contacts	0.3	0.3	0.9	0.5	0.9	0.5	-0.5	-0.7	-0.2
Pavlov. Cond. magazine entry number	1.1	1.4	1.8	-1.1	-1.3	-1.1	1.3	1.0	1.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	0.2	-0.1	0.3	0.0	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.7	0.4	0.8	0.4	-0.5	-0.4	-0.2
Pavlov. Cond. response bias	0.7	0.9	1.5	0.8	1.2	0.9	-1.1	-0.8	-0.8
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.2	0.3	-0.2	0.4	-0.3	0.2
Pavlov. Cond. magazine entry latency	2.2	2.5	3.5	1.8	1.5	1.8	-1.3	-1.9	-1.3
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.2	-0.3	0.1	-0.2	0.0	-0.1
Pavlov. Cond. index score	1.0	1.3	1.7	1.3	0.9	1.3	-1.1	-1.2	-1.0
Pavlov. Cond. latency score	1.0	1.2	1.6	1.3	0.9	1.2	-1.1	-1.1	-1.0
Pavlov. Cond. lever contacts	0.2	0.3	0.5	0.6	0.1	0.6	-0.7	-0.2	-0.5
Pavlov. Cond. magazine entry number	1.5	1.8	2.5	-1.5	-1.2	-1.5	1.1	1.6	1.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.7	-0.7	-0.7	0.8	0.6	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.9	1.4	1.0	1.3	-1.1	-1.2	-1.0
Pavlov. Cond. response bias	0.4	0.5	0.8	0.9	0.3	0.8	-0.7	-0.7	-0.6
Time in closed arm before self-admin	0.3	0.3	0.9	-0.1	-0.1	-0.3	1.0	-0.2	0.8
Time in closed arm after self-admin	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.5	-0.2	0.3
Time in open arm before self-admin	0.9	1.0	2.1	0.8	0.7	0.9	-1.5	-0.5	-1.3
Time in open arm after self-admin	0.7	0.8	1.2	0.8	0.9	0.7	-1.1	-0.5	-1.1
Bone: periosteal estimation	0.4	0.8	1.6	0.7	0.6	0.7	-1.3	-0.5	-1.2
Bone: periosteal perimeter	0.7	1.2	2.2	0.9	0.9	1.0	-1.5	-0.8	-1.4
Bone: post-yield work	0.1	0.1	0.2	0.3	0.4	0.3	-0.4	-0.2	-0.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.0	0.3	0.2	0.1	-0.3	0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.3	-0.0	-0.2	0.3	0.1	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.5	0.1	0.7	0.2	-0.3	-0.2	-0.1
Progressive ratio test 2 active lever presses	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.5	0.3	0.4
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.4	-0.4	-0.4	0.6	0.3	0.5
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.3	-0.6	-0.4	-0.5	0.5	0.6	0.5
Incentive Sensitization - Responses	0.6	0.6	1.0	-0.7	-0.9	-0.8	0.5	1.0	0.5
Incentive Sensitization - Breakpoint	0.6	0.6	1.0	-0.7	-0.9	-0.8	0.5	1.0	0.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.6	-0.6	-0.5	0.6	0.4	0.6
Progressive ratio	0.1	0.1	0.2	0.1	0.0	0.1	0.4	-0.4	0.2
Food seeking constrained by brief footshock	0.2	0.2	0.5	0.5	0.7	0.4	-0.1	-0.7	-0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.0	0.1	0.1	-0.3	-0.1	-0.2
Retroperitoneal fat weight	0.1	0.4	0.4	-0.7	-0.6	-0.6	0.6	0.6	0.6
Reaction time number correct	0.3	0.5	1.2	0.8	0.6	0.8	-0.0	-1.1	-0.2
Reaction time mean minus median	8.2	10.8	12.3	-3.2	-3.5	-3.3	3.4	3.2	3.2
Reaction time mean minus median AUC	6.9	8.9	9.9	-2.9	-3.2	-3.0	3.1	2.9	2.9
Reaction time num false alarms	0.7	1.0	1.3	-1.0	-0.7	-1.1	1.0	1.2	1.0
Reaction time num false alarms AUC	1.2	1.7	2.2	-1.4	-1.0	-1.4	1.2	1.5	1.3
Reaction time trials correct on left	0.3	0.5	1.2	0.8	0.6	0.8	-0.0	-1.1	-0.2
Reaction time trials on left	0.3	0.5	1.1	0.8	0.6	0.8	0.0	-1.1	-0.2
Reaction time mean	3.5	4.9	6.5	-2.2	-2.5	-2.2	1.9	2.5	1.8
Reaction time mean AUC	2.7	3.6	4.8	-1.9	-2.2	-1.9	1.6	2.1	1.6
Median of all reaction times	0.9	1.2	2.1	-1.1	-1.4	-1.1	0.7	1.5	0.6
Reaction time omissions	0.5	0.7	1.6	-0.6	-0.7	-0.7	1.3	0.5	1.1
Reaction time false alarm rate	1.2	1.7	2.9	-1.4	-1.0	-1.5	1.0	1.7	1.1
Reaction time premature initiation rate	1.2	1.6	3.3	1.2	1.1	1.1	-1.8	-0.6	-1.4
Reaction time premature initiations	1.1	1.5	2.3	1.3	1.1	1.2	-1.5	-0.8	-1.2
Std. dev. reaction times	6.6	9.2	11.0	-3.0	-3.3	-3.0	3.0	3.1	2.8
Reaction time trials completed	0.3	0.5	1.1	0.8	0.6	0.8	0.0	-1.1	-0.2
Reaction time trials AUC	0.4	0.6	1.4	0.9	0.7	0.9	-0.1	-1.2	-0.3
Run reversals in cocaine runway, females	0.2	0.2	0.6	-0.5	-0.4	-0.6	-0.0	0.8	0.1
Run reversals in cocaine runway, males	0.4	0.4	0.5	0.7	0.3	0.7	-0.7	-0.7	-0.6
Latency to leave start box in cocaine runway	1.9	2.0	2.7	1.6	1.3	1.5	-1.2	-1.5	-1.3
Latency to leave start box in cocaine runway, F	0.3	0.3	0.5	0.7	0.5	0.6	-0.3	-0.7	-0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.3	0.6	0.3	0.5	-0.5	-0.4	-0.5
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.0	0.6	0.0
Total sessions with >9 infusions	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.2	-0.0	-0.1
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.7	-0.3	-0.5	0.2	0.7	0.4
Short access day 10 total inactive lever presses	0.6	0.6	0.8	0.7	0.9	0.7	-0.9	-0.6	-0.9
Short access day 1 total infusions	0.0	0.0	0.0	-0.2	0.2	-0.0	-0.0	0.0	0.1
Short access day 10 total infusions	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.0	0.4	0.1
Short access total infusions	0.3	0.4	0.5	-0.7	-0.5	-0.6	0.6	0.7	0.6
Short access day 1 locomotion	0.1	0.1	0.2	0.2	0.3	0.3	-0.1	-0.5	-0.1
Short access day 10 total locomotion	1.5	1.7	2.4	-1.5	-1.1	-1.5	1.1	1.5	1.1
Short access total locomotion	0.9	0.9	1.6	-1.1	-0.9	-1.1	0.6	1.3	0.6
One hour access (0.3 mA shock)	0.4	0.5	0.8	-0.7	-0.6	-0.8	0.7	0.9	0.6
Compulsive drug intake	4.2	4.2	4.9	2.2	2.1	2.1	-1.9	-2.1	-1.8
One hour access (shock baseline)	2.0	2.3	2.8	-1.7	-1.5	-1.6	1.4	1.7	1.3
Social response proportion	1.1	1.1	2.1	-1.0	-1.0	-0.9	1.4	0.7	1.3
Social responses	0.2	0.3	1.0	0.3	0.3	0.4	0.6	-1.0	0.4
Social time	1.1	1.5	2.0	-1.3	-1.4	-1.1	1.2	1.0	1.2
Soleus weight	1.0	2.9	4.9	-1.6	-1.6	-1.6	2.2	1.1	2.0
Bone: stiffness	0.2	0.2	0.6	-0.5	-0.5	-0.6	0.1	0.7	0.3
Tibialis anterior weight	0.7	2.5	2.7	1.6	1.6	1.6	-1.5	-1.5	-1.6
Time to tail flick, vehicle, before self-admin	1.4	1.4	1.7	1.2	1.3	1.1	-1.1	-1.1	-1.3
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.0	0.1	-0.1	0.0	0.1	0.0
Time to tail flick, test, before self-admin	0.0	0.0	0.0	-0.1	-0.1	0.0	-0.2	0.0	-0.1
Time to tail flick, test, after self-admin	0.5	0.5	0.9	-0.9	-0.7	-0.8	0.3	0.9	0.2
Delta time to tail flick, vehicle, before/after SA	1.3	1.3	1.6	-1.1	-1.2	-1.1	1.2	1.0	1.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.5	-0.3	-0.6	0.2	0.7	0.3
Tibia length	0.9	2.4	3.0	1.6	1.3	1.6	-1.6	-1.5	-1.7
Ambulatory time before self-admin	0.1	0.1	0.3	0.3	0.1	0.4	-0.3	-0.6	-0.3
Ambulatory time after self-admin	1.0	1.1	1.9	-1.0	-1.4	-1.1	0.7	1.0	0.8
Bone: tissue strength	0.1	0.1	0.2	0.1	-0.3	0.1	-0.5	0.3	-0.3
Total heroin consumption	2.5	3.0	3.4	-1.9	-1.7	-1.7	1.6	1.8	1.6
Bone: trabecular number	0.8	1.3	2.3	-0.8	-1.4	-0.8	1.5	0.6	1.4
Bone: trabecular spacing	2.5	3.3	4.8	1.6	1.8	1.6	-2.2	-1.3	-2.2
Bone: trabecular thickness	0.1	0.1	0.4	-0.3	-0.7	-0.2	0.4	0.2	0.3
Bone: trabecular tissue density	0.6	0.8	1.0	-1.0	-0.8	-1.0	0.8	1.0	0.8
Water consumed over 24 hours	0.1	0.1	0.2	-0.0	-0.5	-0.1	0.0	0.4	0.2
Number of responses in last shaping day	0.2	0.2	0.3	0.6	0.5	0.5	-0.3	-0.5	-0.2