Hub : Genes

Ddx25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ddx25 0.46 0.29 4.1e-05 0.01 0.02 0.02 0.01 4.8e-02 4.8e-03 1.3e-03 8.2e-03
2 Liver gene expression Ddx25 0.24 0.13 1.1e-03 -0 0.02 0.01 -0 9.7e-01 6.7e-03 4.7e-02 7.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.11.82.61.0-1.6
Area under the delay curve0.10.10.10.4-0.2
BMI with tail1.24.05.22.3-1.7
BMI without tail2.55.28.4-2.9-1.4
Body weight0.20.81.60.1-1.2
Weight adjusted by age0.30.30.60.8-0.2
Bone surface2.13.74.71.6-2.2
Bone volume1.01.82.21.2-1.5
Breakpoint value in progressive ratio session0.40.40.70.80.4
Number of licking bursts0.00.00.00.10.1
Context. condit. distance diff. score0.00.00.1-0.30.0
Locomotion velocity, session 10.10.10.2-0.5-0.1
Locomotion distance, session 10.10.10.1-0.2-0.4
Locomotion velocity, session 20.20.30.4-0.3-0.7
Locomotion distance, session 20.20.30.5-0.4-0.7
Locomotion velocity, session 30.20.30.40.3-0.7
Locomotion distance, session 30.00.00.00.00.1
Stereotopy head waving bouts, day 30.30.30.60.8-0.3
Stereotopy head waving duration, day 30.10.10.10.3-0.2
Locomotion velocity, session 70.10.10.10.3-0.2
Locomotion distance, session 70.30.40.5-0.50.7
Stereotopy head waving bouts, day 70.30.30.50.3-0.7
Stereotopy head waving duration, day 70.81.01.30.8-1.1
Locomotion velocity, session 80.30.30.60.2-0.8
Locomotion distance, session 80.20.40.7-0.2-0.8
Degree of sensitization distance0.10.10.1-0.40.2
Degree of sensitization stereotypy0.70.81.30.4-1.2
Conditioned locomotion0.10.10.2-0.50.1
Cocaine response after cond. corrected0.50.50.9-0.50.9
Cocaine response after cond. not corrected0.40.50.9-0.20.9
Cocaine response before conditioning0.10.20.40.6-0.0
Saline control response2.43.23.7-1.61.9
Bone: connectivity density1.52.43.81.0-1.9
Bone: cortical apparent density3.03.95.11.7-2.3
Bone: cortical area10.916.421.53.4-4.6
Bone: cortical porosity4.04.46.11.6-2.5
Bone: cortical porosity3.33.54.71.6-2.2
Bone: cortical thickness6.610.914.52.7-3.8
Bone: cortical thickness7.18.29.72.6-3.1
Bone: cortical tissue density2.73.64.61.6-2.1
Condit. Reinf. active minus inactive responses0.10.10.3-0.10.5
Condit. Reinf. active-inactive response ratio0.00.00.0-0.00.2
Condit. Reinf. active responses0.10.20.3-0.10.6
Condit. Reinf. inactive responses0.20.30.4-0.40.7
Incentive salience index mean0.00.00.10.10.2
Condit. Reinf. lever presses0.10.10.10.4-0.2
Condit. Reinf. active minus inactive responses1.01.22.2-0.51.5
Condit. Reinf. active-inactive response ratio0.30.30.60.10.8
Condit. Reinf. active responses1.72.33.7-1.01.9
Condit. Reinf. inactive responses1.51.81.9-1.31.4
Condit. Reinf. lever presses0.40.50.9-0.40.9
Condit. Reinf. lever reinforcers received1.21.62.6-0.81.6
Conditioned reinforcement - actives0.00.00.00.10.1
Conditioned reinforcement - inactives7.58.416.8-4.1-0.0
Conditioned locomotion1.31.53.0-1.70.0
Patch foraging indifference point 0 sec1.52.54.8-2.2-0.5
Patch foraging indifference point AUC2.12.52.81.7-1.5
Delay disc. indifference point, 0s delay0.10.10.10.4-0.3
Delay disc. indifference point, 16s delay1.01.01.91.40.1
Delay disc. indifference point, 2s delay0.10.10.2-0.50.2
Delay disc. indifference point, 24s delay0.40.30.70.80.1
Delay disc. indifference point, 4s delay0.10.10.10.2-0.3
Delay disc. indifference point, 8s delay0.60.61.0-1.0-0.4
Indifference point function ln k0.91.32.3-1.5-0.4
Indifference point function log k0.91.32.3-1.5-0.4
Patch foraging total patch changes 0 sec1.62.64.9-2.2-0.5
Patch foraging total patch changes 12 sec1.41.83.5-1.90.3
Patch foraging total patch changes 18 sec2.12.74.6-2.10.8
Patch foraging total patch changes 24 sec0.10.10.1-0.4-0.1
Patch foraging total patch changes 6 sec0.10.10.2-0.2-0.4
Patch foraging time to switch 0 sec0.60.91.50.51.2
Patch foraging water rate 0 sec0.50.80.9-0.8-0.9
Patch foraging water rate 12 sec0.20.30.4-0.50.6
Patch foraging water rate 18 sec0.00.00.00.10.0
Patch foraging water rate 24 sec0.50.71.3-1.1-0.4
Patch foraging water rate 6 sec1.32.03.5-1.90.7
Seeking ratio, delayed vs. immediate footshock0.20.20.30.60.2
Distance traveled before self-admin8.18.617.24.1-0.0
Distance traveled after self-admin6.16.813.43.7-0.5
Extensor digitorum longus weight1.45.49.2-1.33.0
Bone: elastic displacement0.91.01.2-1.10.9
Bone: elastic work4.86.28.02.1-2.8
Bone: endosteal estimation0.92.02.31.3-1.5
Bone: endosteal perimeter0.40.71.20.5-1.1
Epididymis fat weight0.41.01.5-0.8-1.2
Delta time in closed arm before/after self-admin3.33.26.2-2.5-0.3
Delta time in open arm before/after self-admin1.71.73.3-1.8-0.0
Diff in mean of infusions in LGA sessions0.10.10.10.40.1
Delay discount exponential model param0.00.00.1-0.30.1
Extinction: sum of active levers before priming11.911.923.7-4.9-0.1
Active lever presses in extinction session 64.94.79.23.00.5
Bone: final force6.510.512.52.9-3.5
Bone: final moment5.99.611.72.7-3.4
Food consumed during 24 hour testing period0.10.10.10.20.3
Glucose0.00.10.1-0.2-0.3
Heart weight1.21.73.3-1.80.0
Delay discount hyperbolic model param0.00.10.1-0.30.1
Intermittent access intake day 1-15 change39.739.278.0-8.8-0.6
Intermittent access intake escalation20.820.440.5-6.4-0.6
Intermittent access intake escalation 216.816.632.7-5.7-0.7
Intermitt. access day 1 inactive lever presses12.913.827.55.2-0.1
Intermitt. access day 15 inactive lever presses20.422.444.8-6.7-0.0
Intermitt. access escalation Index7.46.512.93.6-0.4
Intermittent access day 1 total infusions1.01.22.4-1.60.1
Intermittent access day 15 total infusions22.124.749.3-7.0-0.4
Intermittent access terminal intake (last 3 days)22.024.148.0-6.9-0.3
Intermittent access total infusions12.714.128.2-5.3-0.1
Intermittent access day 1 locomotion0.10.10.2-0.40.3
Intermittent access day 15 total locomotion1.11.22.4-1.6-0.1
Intermittent access total locomotion0.50.61.2-1.10.0
Intermittent access standard deviation7.98.416.5-4.1-0.6
Left kidney weight0.10.40.70.0-0.9
Right kidney weight1.54.36.2-2.5-1.6
Cocaine induced anxiety6.47.314.6-3.80.3
Post-drug Anxiety0.10.10.1-0.30.2
Baseline Anxiety2.83.06.02.4-0.3
Tail length3.19.318.4-4.30.5
Length with tail0.51.83.6-1.90.1
Length without tail2.65.611.23.3-0.1
Times rat made contact with spout0.00.00.00.10.1
Lifetime Intake21.524.448.7-7.0-0.1
Liver weight, left1.62.53.71.9-1.1
Liver weight, right0.10.20.40.6-0.3
Locomotor activity2.33.67.1-2.7-0.4
Locomotor testing distance2.54.27.9-2.8-0.7
Locomotor testing rearing1.72.65.1-2.30.0
Locomotion in novel chamber0.10.10.10.40.0
Locomotion in novel chamber post-restriction0.10.10.2-0.5-0.0
Fecal boli incidents, locomotor time 10.30.30.50.70.3
Change in fecal boli incidents, locomotor task0.00.00.0-0.20.2
Time >=10cm from walls, locomotor time 10.60.61.21.1-0.2
Bouts of movement, locomotor time 10.10.10.10.20.3
Total resting periods, locomotor time 10.10.10.10.30.3
Rest time, locomotor task time 10.70.81.51.20.3
Distance moved, locomotor task time 10.30.30.5-0.7-0.2
Vertical activity count, locomotor time 10.20.20.30.60.1
Time >=10cm from walls, locomotor time 20.10.10.2-0.3-0.4
Bouts of movement, locomotor time 22.02.24.2-2.00.5
Total resting periods, locomotor time 21.61.73.0-1.70.6
Rest time, locomotor task time 20.70.91.51.20.4
Distance moved, locomotor task time 20.91.12.0-1.4-0.5
Vertical activity count, locomotor time 20.30.30.6-0.8-0.2
Light reinforcement 10.20.30.6-0.1-0.7
Light reinforcement 20.91.21.21.1-1.1
Bone: marrow area1.02.12.51.3-1.6
Bone: maximum diameter1.93.54.61.6-2.1
Bone: maximum force8.414.517.43.4-4.2
Bone: maximum moment7.613.116.23.2-4.0
Mean time between licks in bursts0.00.00.0-0.0-0.1
Mean num. licks in bursts0.00.00.0-0.1-0.0
Cd content in liver0.20.20.30.6-0.4
Co content in liver8.39.714.82.1-3.9
Cu content in liver0.20.30.4-0.40.6
Fe content in liver5.56.611.2-1.43.4
K content in liver1.01.02.0-1.4-0.0
Mg content in liver1.71.83.0-1.70.7
Mn content in liver1.01.22.0-1.40.6
Na content in liver0.30.30.5-0.70.1
Rb content in liver0.20.20.4-0.60.3
Se content in liver0.30.40.70.3-0.8
Sr content in liver9.58.78.93.0-2.9
Zn content in liver0.40.50.70.4-0.9
Bone: minimum diameter6.111.416.12.6-4.0
Time in familiar zone, hab. session 10.20.20.2-0.3-0.5
Time in novel zone, hab. session 10.10.10.20.30.5
Total zone transitions, hab. session 10.00.00.00.1-0.1
Total locomotion distance, hab. session 10.00.00.0-0.1-0.2
Locomotion velocity, hab. session 10.00.10.1-0.1-0.3
Time in familiar zone, hab. session 20.00.00.0-0.10.0
Time in novel zone, hab. session 20.00.00.00.00.0
Total zone transitions, hab. session 20.20.30.60.1-0.8
Total locomotion distance, hab. session 20.10.10.20.2-0.5
Locomotion velocity, hab. session 20.10.10.20.2-0.5
Novel to familiar place preference ratio0.00.00.00.10.0
Novelty place preference0.00.00.00.10.0
Time in novel zone, NPP test0.00.00.00.10.1
Total zone transitions, NPP test0.20.20.5-0.0-0.7
Total locomotion distance, NPP test0.10.10.20.0-0.4
Locomotion velocity, NPP test0.10.20.30.0-0.6
Intraocular pressure0.10.20.3-0.40.5
Delta distance traveled before/after self-admin3.43.77.3-2.7-0.3
Delta ambulatory time before/after self-admin7.38.015.9-4.0-0.4
Parametrial fat weight1.63.25.4-2.3-1.0
Pavlov. Cond. lever latency0.40.50.7-0.80.6
Pavlov. Cond. magazine entry latency1.92.52.91.4-1.7
Pavlov. Cond. change in total contacts0.91.01.7-0.51.3
Pavlov. Cond. index score0.50.70.70.8-0.8
Pavlov. Cond. latency score0.30.40.50.7-0.5
Pavlov. Cond. lever contacts0.10.10.10.4-0.1
Pavlov. Cond. magazine entry number0.91.11.4-0.91.2
Pavlov. Cond. intertrial magazine entries1.21.52.6-0.61.6
Pavlov. Cond. lever-magazine prob. diff.0.70.81.01.0-0.8
Pavlov. Cond. response bias0.20.20.30.6-0.3
Pavlov. Cond. lever latency0.30.40.5-0.70.6
Pavlov. Cond. magazine entry latency0.10.10.30.1-0.5
Pavlov. Cond. change in total contacts0.30.40.40.6-0.6
Pavlov. Cond. index score0.10.20.20.4-0.4
Pavlov. Cond. latency score0.00.00.00.1-0.0
Pavlov. Cond. lever contacts0.00.10.10.2-0.3
Pavlov. Cond. magazine entry number0.10.10.1-0.20.3
Pavlov. Cond. intertrial magazine entries0.50.60.8-0.60.9
Pavlov. Cond. lever-magazine prob. diff.0.40.50.50.6-0.7
Pavlov. Cond. response bias0.20.30.30.5-0.5
Time in closed arm before self-admin0.70.81.61.3-0.1
Time in closed arm after self-admin0.70.81.51.2-0.2
Time in open arm before self-admin0.10.10.30.50.2
Time in open arm after self-admin2.22.54.9-2.20.1
Bone: periosteal estimation5.010.413.02.8-3.6
Bone: periosteal perimeter3.66.08.12.0-2.8
Bone: post-yield work1.01.42.10.8-1.4
Progressive ratio test 1 active lever presses4.54.79.3-3.10.2
Progressive ratio test 1 breakpoint3.43.67.2-2.70.2
Progressive ratio test 1 inactive lever presses7.07.715.4-3.9-0.0
Progressive ratio test 2 active lever presses7.88.416.8-4.1-0.2
Progressive ratio test 2 breakpoint9.510.621.2-4.6-0.3
Progressive ratio test 2 inactive lever presses19.122.044.0-6.6-0.2
Incentive Sensitization - Responses9.49.619.0-4.4-0.3
Incentive Sensitization - Breakpoint10.710.921.7-4.7-0.3
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.1
Progressive ratio0.40.40.8-0.9-0.3
Food seeking constrained by brief footshock0.30.40.6-0.3-0.8
Seeking ratio, punishment vs. effort0.20.20.40.6-0.3
Retroperitoneal fat weight0.31.11.40.9-1.2
Reaction time number correct0.20.30.7-0.8-0.1
Reaction time mean minus median2.73.64.2-1.72.1
Reaction time mean minus median AUC4.45.76.4-2.32.5
Reaction time num false alarms1.52.13.60.7-1.9
Reaction time num false alarms AUC3.24.47.90.9-2.8
Reaction time trials correct on left0.20.30.7-0.8-0.1
Reaction time trials on left0.30.40.9-0.9-0.0
Reaction time mean4.46.16.7-2.62.4
Reaction time mean AUC3.75.05.3-2.22.3
Median of all reaction times3.24.44.8-2.22.0
Reaction time omissions1.82.43.7-1.91.1
Reaction time false alarm rate2.73.75.41.4-2.3
Reaction time premature initiation rate0.71.01.8-0.31.3
Reaction time premature initiations0.50.71.2-0.51.1
Std. dev. reaction times1.82.52.6-1.61.6
Reaction time trials completed0.30.40.9-0.9-0.0
Reaction time trials AUC0.20.30.6-0.80.0
Run reversals in cocaine runway, females2.12.14.1-2.0-0.2
Run reversals in cocaine runway, males4.34.18.1-2.8-0.4
Latency to leave start box in cocaine runway3.03.36.42.50.4
Latency to leave start box in cocaine runway, F0.60.61.31.10.2
Latency to leave start box in cocaine runway, M5.55.310.33.20.5
Std. dev. time between licks in bursts0.00.00.00.0-0.0
Total sessions with >9 infusions9.410.420.8-4.6-0.1
Short access day 1 total inactive lever presses0.91.02.01.40.2
Short access day 10 total inactive lever presses0.60.71.31.2-0.1
Short access day 1 total infusions25.226.953.7-7.30.0
Short access day 10 total infusions16.518.336.6-6.10.0
Short access total infusions27.330.761.4-7.8-0.1
Short access day 1 locomotion2.32.44.8-2.20.3
Short access day 10 total locomotion5.76.412.73.60.4
Short access total locomotion0.30.30.50.70.3
One hour access (0.3 mA shock)35.241.182.2-9.1-0.2
Compulsive drug intake0.00.00.0-0.0-0.0
One hour access (shock baseline)20.223.446.9-6.8-0.1
Social response proportion0.50.60.91.0-0.5
Social responses0.10.10.10.3-0.4
Social time0.00.00.0-0.20.1
Soleus weight2.67.713.9-1.23.7
Bone: stiffness5.89.110.32.8-3.2
Tibialis anterior weight1.34.37.5-1.12.7
Time to tail flick, vehicle, before self-admin4.64.79.5-3.1-0.1
Time to tail flick, vehicle, after self-admin0.70.81.5-1.2-0.0
Time to tail flick, test, before self-admin3.02.95.7-2.40.2
Time to tail flick, test, after self-admin0.80.81.6-1.3-0.2
Delta time to tail flick, vehicle, before/after SA2.42.44.72.20.0
Delta time to tail flick, test, before/after SA1.21.12.01.4-0.3
Tibia length0.61.82.41.1-1.6
Ambulatory time before self-admin14.314.929.75.5-0.0
Ambulatory time after self-admin2.93.16.22.5-0.3
Bone: tissue strength0.00.00.10.1-0.3
Total heroin consumption4.65.410.43.20.6
Bone: trabecular number0.10.20.3-0.60.3
Bone: trabecular spacing1.11.52.0-1.01.4
Bone: trabecular thickness5.46.57.82.3-2.8
Bone: trabecular tissue density0.10.10.20.20.4
Water consumed over 24 hours0.10.10.20.30.4
Number of responses in last shaping day15.516.131.9-5.70.5