Hub : Genes

Dcdc1-ps1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Eye	mRNA stability	Dcdc1-ps1	0.39	0.29	9.0e-03	0.07	-0	-0.01	0.03	3.6e-02	4.0e-01	4.1e-01	1.1e-01
2	pVTA	gene expression	Dcdc1-ps1	0.03	0.02	4.2e-03	0.01	0.03	0.02	0.02	3.1e-02	2.3e-03	4.3e-03	1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	1.4	2.4	2.9	-1.7	1.4
Area under the delay curve	0.1	0.1	0.2	-0.0	0.5
BMI with tail	0.1	0.4	0.5	-0.7	0.6
BMI without tail	1.1	3.4	5.0	-1.3	2.2
Body weight	1.6	7.1	9.2	-2.3	3.0
Weight adjusted by age	0.2	0.4	0.7	0.3	0.8
Bone surface	1.3	2.4	2.7	-1.7	1.5
Bone volume	2.3	4.1	4.9	-2.2	1.8
Breakpoint value in progressive ratio session	1.7	2.0	3.3	1.8	-0.9
Number of licking bursts	0.7	1.1	1.5	-1.2	0.8
Context. condit. distance diff. score	2.9	3.5	3.8	-1.8	2.0
Locomotion velocity, session 1	1.1	1.2	2.1	0.6	-1.4
Locomotion distance, session 1	0.4	0.5	0.8	0.4	-0.9
Locomotion velocity, session 2	0.1	0.1	0.2	-0.5	-0.2
Locomotion distance, session 2	0.1	0.2	0.3	-0.3	-0.6
Locomotion velocity, session 3	0.2	0.2	0.4	-0.6	0.1
Locomotion distance, session 3	0.1	0.2	0.3	-0.5	0.1
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.2	-0.3
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	0.5
Locomotion distance, session 7	0.0	0.0	0.1	-0.3	-0.0
Stereotopy head waving bouts, day 7	0.7	0.8	1.2	0.6	-1.1
Stereotopy head waving duration, day 7	0.3	0.3	0.4	0.5	-0.6
Locomotion velocity, session 8	0.2	0.3	0.4	-0.6	0.5
Locomotion distance, session 8	1.4	2.1	2.6	-1.6	1.2
Degree of sensitization distance	0.1	0.1	0.2	0.4	-0.3
Degree of sensitization stereotypy	0.7	0.8	1.1	0.7	-1.0
Conditioned locomotion	4.8	5.5	7.4	2.7	-1.9
Cocaine response after cond. corrected	4.9	5.9	6.9	2.2	-2.6
Cocaine response after cond. not corrected	1.8	2.1	2.7	1.2	-1.7
Cocaine response before conditioning	6.2	7.5	7.6	-2.7	2.8
Saline control response	0.1	0.2	0.3	-0.1	0.5
Bone: connectivity density	0.7	1.1	1.5	-1.2	0.9
Bone: cortical apparent density	0.0	0.0	0.0	0.1	-0.1
Bone: cortical area	2.5	3.8	4.9	-2.2	1.6
Bone: cortical porosity	0.2	0.2	0.3	0.6	-0.2
Bone: cortical porosity	0.1	0.1	0.1	0.2	0.3
Bone: cortical thickness	0.3	0.6	0.9	-1.0	0.5
Bone: cortical thickness	0.5	0.6	0.8	0.7	-0.9
Bone: cortical tissue density	0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. active minus inactive responses	1.8	2.0	2.2	-1.5	1.3
Condit. Reinf. active-inactive response ratio	5.2	5.6	5.8	-2.3	2.4
Condit. Reinf. active responses	0.8	1.0	1.5	-1.2	0.7
Condit. Reinf. inactive responses	0.5	0.6	1.2	0.3	-1.1
Incentive salience index mean	1.2	1.5	1.7	-1.3	1.1
Condit. Reinf. lever presses	0.3	0.4	0.5	-0.7	0.6
Condit. Reinf. active minus inactive responses	2.2	2.8	3.4	-1.9	1.5
Condit. Reinf. active-inactive response ratio	4.1	4.7	5.6	-2.4	2.0
Condit. Reinf. active responses	1.9	2.6	3.0	-1.7	1.5
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.2	0.5
Condit. Reinf. lever presses	2.7	3.8	4.2	-1.8	2.1
Condit. Reinf. lever reinforcers received	1.9	2.7	3.0	-1.7	1.5
Conditioned reinforcement - actives	1.8	3.1	4.5	-2.1	1.3
Conditioned reinforcement - inactives	4.2	6.2	10.0	-3.2	1.5
Conditioned locomotion	3.0	3.9	5.7	-2.4	1.4
Patch foraging indifference point 0 sec	0.2	0.3	0.6	-0.8	0.1
Patch foraging indifference point AUC	1.9	2.8	3.8	1.3	-1.9
Delay disc. indifference point, 0s delay	0.8	0.9	1.1	-0.8	1.0
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	0.2	-0.0
Delay disc. indifference point, 2s delay	0.6	0.7	1.0	-0.6	1.0
Delay disc. indifference point, 24s delay	0.4	0.5	0.6	0.6	-0.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.5	0.4
Delay disc. indifference point, 8s delay	0.3	0.3	0.6	-0.3	0.8
Indifference point function ln k	1.7	2.9	4.6	-1.1	2.1
Indifference point function log k	1.7	2.9	4.6	-1.1	2.1
Patch foraging total patch changes 0 sec	0.2	0.4	0.8	-0.9	0.2
Patch foraging total patch changes 12 sec	0.6	0.8	1.5	-1.2	-0.2
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	-0.1	-0.7
Patch foraging total patch changes 24 sec	0.4	0.6	0.7	-0.8	0.8
Patch foraging total patch changes 6 sec	0.0	0.1	0.1	-0.3	-0.2
Patch foraging time to switch 0 sec	0.3	0.6	1.0	-1.0	0.5
Patch foraging water rate 0 sec	0.0	0.1	0.1	-0.1	0.3
Patch foraging water rate 12 sec	0.5	1.1	2.1	-0.1	1.5
Patch foraging water rate 18 sec	1.1	1.6	3.1	-0.4	1.8
Patch foraging water rate 24 sec	0.9	1.2	2.4	-0.3	1.6
Patch foraging water rate 6 sec	0.2	0.3	0.5	0.2	0.7
Seeking ratio, delayed vs. immediate footshock	1.5	1.8	3.1	-0.7	1.8
Distance traveled before self-admin	0.0	0.0	0.0	0.1	0.2
Distance traveled after self-admin	1.5	1.8	3.1	-0.8	1.8
Extensor digitorum longus weight	0.0	0.2	0.4	-0.6	-0.2
Bone: elastic displacement	0.6	0.7	1.0	0.6	-1.0
Bone: elastic work	0.2	0.3	0.5	-0.7	0.3
Bone: endosteal estimation	0.2	0.4	0.5	-0.7	0.5
Bone: endosteal perimeter	1.2	2.5	2.9	-1.7	1.5
Epididymis fat weight	2.5	8.6	9.0	-2.9	3.0
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.0	-0.7
Delta time in open arm before/after self-admin	0.4	0.4	0.5	0.5	-0.7
Diff in mean of infusions in LGA sessions	0.2	0.3	0.5	0.7	-0.1
Delay discount exponential model param	0.1	0.1	0.2	-0.1	-0.4
Extinction: sum of active levers before priming	0.2	0.2	0.4	0.6	-0.3
Active lever presses in extinction session 6	0.5	0.5	1.0	0.0	1.0
Bone: final force	1.5	2.4	2.9	-1.7	1.4
Bone: final moment	1.3	2.1	2.5	-1.6	1.3
Food consumed during 24 hour testing period	2.1	2.8	2.9	-1.7	1.7
Glucose	2.1	3.3	3.4	-1.8	1.8
Heart weight	1.3	2.0	4.0	0.1	2.0
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.1	-0.4
Intermittent access intake day 1-15 change	0.2	0.4	0.8	-0.9	0.2
Intermittent access intake escalation	0.2	0.4	0.7	-0.9	0.2
Intermittent access intake escalation 2	0.5	0.6	0.8	-0.9	0.6
Intermitt. access day 1 inactive lever presses	0.2	0.6	0.9	-0.9	0.6
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	-0.3	0.3
Intermitt. access escalation Index	1.0	1.4	1.6	1.3	-1.1
Intermittent access day 1 total infusions	0.6	1.0	1.7	-1.3	0.6
Intermittent access day 15 total infusions	1.1	1.6	2.9	-1.7	0.5
Intermittent access terminal intake (last 3 days)	1.2	1.6	2.9	-1.7	0.5
Intermittent access total infusions	1.5	1.8	3.2	-1.8	0.6
Intermittent access day 1 locomotion	0.9	1.1	2.1	-1.5	0.4
Intermittent access day 15 total locomotion	0.3	0.6	1.1	-1.1	0.0
Intermittent access total locomotion	0.9	1.1	2.2	-1.5	0.0
Intermittent access standard deviation	0.6	1.3	1.9	-1.4	0.8
Left kidney weight	2.1	9.8	12.0	-2.8	3.5
Right kidney weight	3.8	17.2	20.4	-3.7	4.5
Cocaine induced anxiety	0.8	1.2	1.2	-1.1	1.1
Post-drug Anxiety	0.7	0.7	1.5	0.1	1.2
Baseline Anxiety	1.0	1.1	2.2	1.5	0.1
Tail length	1.9	7.3	12.4	-1.5	3.5
Length with tail	2.8	12.4	16.8	-2.8	4.1
Length without tail	1.9	6.2	7.2	-2.7	2.3
Times rat made contact with spout	0.1	0.1	0.1	-0.2	0.3
Lifetime Intake	1.3	1.6	3.2	-1.8	0.1
Liver weight, left	6.2	10.2	12.2	-2.9	3.5
Liver weight, right	2.8	4.9	5.0	-2.2	2.2
Locomotor activity	0.0	0.1	0.1	-0.1	-0.3
Locomotor testing distance	1.5	2.7	3.5	-1.9	1.4
Locomotor testing rearing	0.3	0.5	0.6	-0.7	0.7
Locomotion in novel chamber	2.0	2.5	3.9	-1.1	2.0
Locomotion in novel chamber post-restriction	0.5	0.9	1.1	1.1	-0.8
Fecal boli incidents, locomotor time 1	3.7	5.3	6.6	2.6	-2.0
Change in fecal boli incidents, locomotor task	3.0	2.9	3.3	-1.6	1.8
Time >=10cm from walls, locomotor time 1	1.2	1.3	1.4	1.2	-1.1
Bouts of movement, locomotor time 1	1.1	1.3	1.5	1.1	-1.2
Total resting periods, locomotor time 1	1.8	2.0	2.3	1.3	-1.5
Rest time, locomotor task time 1	3.6	4.5	4.7	2.2	-2.1
Distance moved, locomotor task time 1	1.6	2.3	2.4	-1.6	1.5
Vertical activity count, locomotor time 1	0.5	1.2	2.0	-0.7	1.4
Time >=10cm from walls, locomotor time 2	2.0	2.9	4.0	-1.3	2.0
Bouts of movement, locomotor time 2	0.5	0.8	1.1	-1.1	0.6
Total resting periods, locomotor time 2	0.3	0.5	1.0	-1.0	0.3
Rest time, locomotor task time 2	5.8	7.4	9.6	2.3	-3.1
Distance moved, locomotor task time 2	3.7	4.4	5.7	-1.7	2.4
Vertical activity count, locomotor time 2	4.9	6.7	9.1	-2.1	3.0
Light reinforcement 1	0.1	0.2	0.4	-0.4	0.6
Light reinforcement 2	0.8	1.2	1.7	0.9	-1.3
Bone: marrow area	0.2	0.3	0.5	-0.7	0.5
Bone: maximum diameter	1.1	2.0	2.8	-1.7	1.1
Bone: maximum force	2.2	3.9	4.1	-2.0	1.9
Bone: maximum moment	1.8	3.1	3.2	-1.8	1.7
Mean time between licks in bursts	0.0	0.1	0.1	0.2	-0.3
Mean num. licks in bursts	0.5	0.7	1.0	1.0	-0.6
Cd content in liver	1.5	1.7	2.5	-1.6	0.9
Co content in liver	0.9	1.0	1.5	0.8	-1.2
Cu content in liver	1.9	2.2	2.4	1.5	-1.4
Fe content in liver	0.1	0.1	0.2	-0.1	-0.4
K content in liver	0.1	0.1	0.1	0.2	-0.3
Mg content in liver	0.0	0.0	0.0	-0.2	-0.0
Mn content in liver	0.8	0.8	0.9	0.9	-1.0
Na content in liver	0.6	0.6	0.9	-0.5	1.0
Rb content in liver	1.5	1.8	2.3	1.1	-1.5
Se content in liver	1.7	2.0	3.0	1.7	-1.0
Sr content in liver	0.1	0.1	0.2	0.5	0.1
Zn content in liver	0.1	0.1	0.2	-0.0	-0.4
Bone: minimum diameter	3.2	5.8	6.8	-2.6	2.2
Time in familiar zone, hab. session 1	0.8	0.8	0.9	0.8	-0.9
Time in novel zone, hab. session 1	1.6	1.6	1.7	-1.3	1.2
Total zone transitions, hab. session 1	0.9	1.3	1.3	-1.2	1.1
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.6	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.5	0.1
Time in familiar zone, hab. session 2	0.0	0.0	0.0	0.0	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.2	0.5
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	0.0
Total locomotion distance, hab. session 2	0.5	0.7	1.0	0.6	-1.0
Locomotion velocity, hab. session 2	0.5	0.6	1.0	0.5	-1.0
Novel to familiar place preference ratio	1.3	1.4	1.5	-1.2	1.2
Novelty place preference	1.4	1.5	1.6	-1.2	1.3
Time in novel zone, NPP test	1.2	1.3	1.4	-1.1	1.2
Total zone transitions, NPP test	1.6	2.3	2.4	1.5	-1.6
Total locomotion distance, NPP test	1.4	2.0	2.0	1.4	-1.4
Locomotion velocity, NPP test	1.2	1.7	1.8	1.3	-1.3
Intraocular pressure	0.7	1.1	1.9	0.4	-1.4
Delta distance traveled before/after self-admin	0.3	0.3	0.6	-0.1	0.8
Delta ambulatory time before/after self-admin	0.6	0.8	1.1	-0.7	1.1
Parametrial fat weight	0.0	0.0	0.0	-0.1	-0.0
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.4	-0.2
Pavlov. Cond. magazine entry latency	0.7	0.9	1.2	-1.1	0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.2	0.1
Pavlov. Cond. index score	0.1	0.2	0.3	-0.5	0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.6	0.2
Pavlov. Cond. lever contacts	0.1	0.2	0.2	-0.5	0.4
Pavlov. Cond. magazine entry number	0.9	1.1	1.4	1.2	-0.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.7	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.1	-0.3	0.2
Pavlov. Cond. response bias	0.3	0.4	0.5	-0.7	0.5
Pavlov. Cond. lever latency	2.8	3.7	4.3	1.8	-2.1
Pavlov. Cond. magazine entry latency	1.0	1.2	1.4	-1.2	1.0
Pavlov. Cond. change in total contacts	0.7	1.2	1.3	-1.0	1.2
Pavlov. Cond. index score	3.0	4.0	4.3	-1.9	2.1
Pavlov. Cond. latency score	3.0	4.0	4.3	-1.9	2.1
Pavlov. Cond. lever contacts	3.3	4.6	5.2	-2.0	2.3
Pavlov. Cond. magazine entry number	1.8	2.3	2.4	1.6	-1.5
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	-0.5	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.5	3.8	-1.8	2.0
Pavlov. Cond. response bias	3.2	4.4	4.6	-2.0	2.1
Time in closed arm before self-admin	2.9	3.7	4.4	-2.1	1.7
Time in closed arm after self-admin	2.8	3.0	4.2	-2.1	1.3
Time in open arm before self-admin	2.3	2.5	4.6	2.1	-0.6
Time in open arm after self-admin	4.6	5.1	8.4	2.9	-1.3
Bone: periosteal estimation	0.9	1.9	2.6	-1.6	1.1
Bone: periosteal perimeter	1.8	3.1	3.8	-1.9	1.5
Bone: post-yield work	0.1	0.2	0.4	-0.1	0.6
Progressive ratio test 1 active lever presses	1.1	1.4	2.7	-1.6	0.3
Progressive ratio test 1 breakpoint	1.1	1.3	2.5	-1.6	0.3
Progressive ratio test 1 inactive lever presses	0.5	0.8	1.5	-1.2	-0.3
Progressive ratio test 2 active lever presses	2.5	3.0	4.9	-2.2	1.0
Progressive ratio test 2 breakpoint	2.6	3.0	4.8	-2.2	1.1
Progressive ratio test 2 inactive lever presses	2.9	4.7	7.6	-2.8	1.4
Incentive Sensitization - Responses	0.5	0.7	1.4	-1.2	0.3
Incentive Sensitization - Breakpoint	0.5	0.7	1.3	-1.1	0.3
Sum of active levers in priming session hrs 5-6	2.2	2.1	3.7	1.9	-0.7
Progressive ratio	0.0	0.1	0.1	-0.4	-0.1
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.2	-0.4
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	-0.0	-0.4
Retroperitoneal fat weight	17.0	72.6	77.7	-8.8	8.2
Reaction time number correct	0.3	0.6	1.2	0.0	1.1
Reaction time mean minus median	0.0	0.1	0.2	-0.5	0.1
Reaction time mean minus median AUC	0.1	0.4	0.4	-0.6	0.6
Reaction time num false alarms	0.2	0.3	0.4	0.6	-0.5
Reaction time num false alarms AUC	0.5	0.9	1.0	1.0	-0.8
Reaction time trials correct on left	0.3	0.6	1.2	0.0	1.1
Reaction time trials on left	0.3	0.5	1.1	0.1	1.0
Reaction time mean	0.5	0.8	1.2	-1.1	0.6
Reaction time mean AUC	0.6	0.9	1.3	-1.1	0.8
Median of all reaction times	0.7	0.9	1.3	-1.2	0.7
Reaction time omissions	0.2	0.3	0.5	-0.2	-0.7
Reaction time false alarm rate	1.0	1.3	1.6	1.0	-1.3
Reaction time premature initiation rate	0.3	0.4	0.4	0.6	-0.6
Reaction time premature initiations	0.2	0.3	0.6	0.8	-0.2
Std. dev. reaction times	0.4	0.7	1.1	-1.0	0.6
Reaction time trials completed	0.3	0.5	1.1	0.1	1.0
Reaction time trials AUC	0.3	0.6	1.2	-0.1	1.1
Run reversals in cocaine runway, females	1.5	1.5	2.1	-0.9	1.5
Run reversals in cocaine runway, males	0.7	0.7	1.3	0.3	-1.1
Latency to leave start box in cocaine runway	1.8	2.0	3.1	1.8	-1.0
Latency to leave start box in cocaine runway, F	1.1	1.3	2.0	1.4	-0.8
Latency to leave start box in cocaine runway, M	0.5	0.5	0.9	1.0	-0.2
Std. dev. time between licks in bursts	2.4	3.2	3.7	-1.9	1.6
Total sessions with >9 infusions	1.0	1.2	2.1	-1.5	-0.6
Short access day 1 total inactive lever presses	0.6	0.7	1.5	-1.2	0.1
Short access day 10 total inactive lever presses	0.2	0.4	0.8	-0.2	0.9
Short access day 1 total infusions	2.1	2.7	4.9	-2.2	-0.7
Short access day 10 total infusions	1.3	1.6	2.8	-1.7	-0.7
Short access total infusions	1.1	1.5	1.9	-1.4	-1.0
Short access day 1 locomotion	1.0	1.2	2.4	-1.5	-0.1
Short access day 10 total locomotion	0.3	0.5	0.8	-0.9	-0.5
Short access total locomotion	0.8	1.0	1.9	-1.4	0.1
One hour access (0.3 mA shock)	2.2	2.6	4.6	-2.1	0.8
Compulsive drug intake	2.1	2.5	2.8	1.7	-1.5
One hour access (shock baseline)	3.2	4.9	7.5	-2.7	1.5
Social response proportion	1.9	2.2	2.9	1.2	-1.7
Social responses	0.1	0.1	0.2	-0.5	0.1
Social time	5.5	7.5	9.4	2.4	-3.1
Soleus weight	0.0	0.1	0.2	-0.1	-0.5
Bone: stiffness	2.2	3.6	3.9	-2.0	1.8
Tibialis anterior weight	0.7	2.4	3.7	1.1	-1.9
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.3	-0.5	0.6
Time to tail flick, vehicle, after self-admin	2.3	3.1	4.2	-2.1	1.4
Time to tail flick, test, before self-admin	0.4	0.4	0.6	-0.8	0.4
Time to tail flick, test, after self-admin	0.7	0.7	1.4	-1.2	0.2
Delta time to tail flick, vehicle, before/after SA	1.5	1.4	1.5	-1.1	1.2
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.1	-0.5
Tibia length	0.3	0.7	0.8	0.9	-0.8
Ambulatory time before self-admin	0.0	0.0	0.1	-0.0	0.3
Ambulatory time after self-admin	1.3	1.5	2.6	-0.7	1.6
Bone: tissue strength	0.9	0.9	1.2	1.1	-0.8
Total heroin consumption	1.2	1.5	2.3	1.5	-0.8
Bone: trabecular number	1.1	1.8	1.9	-1.4	1.3
Bone: trabecular spacing	0.1	0.2	0.3	0.2	-0.5
Bone: trabecular thickness	1.4	1.8	2.2	-1.5	1.2
Bone: trabecular tissue density	0.4	0.6	0.8	0.9	-0.6
Water consumed over 24 hours	0.6	0.8	1.2	-1.1	0.6
Number of responses in last shaping day	2.3	2.5	3.9	-2.0	1.1