Hub : Genes

Dbi

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Dbi 0.28 0.12 4.3e-10 0.05 0.04 0.05 0.05 6.0e-06 8.9e-06 7.5e-06 3.0e-06
2 BLA mRNA stability Dbi 0.49 0.07 0.0e+00 0.3 0.34 0.36 0.35 1.7e-16 5.7e-19 1.0e-19 1.8e-19
3 IL gene expression Dbi 0.58 0.12 3.4e-06 0.1 0.1 0.1 0.13 1.7e-03 2.8e-03 1.8e-03 5.5e-04
4 Adipose gene expression Dbi 0.46 0.06 0.0e+00 0.17 0.17 0.17 0.17 6.6e-19 6.4e-19 2.3e-18 5.9e-19
5 NAcc gene expression Dbi 0.21 0.06 3.3e-16 0.08 0.09 0.1 0.1 3.0e-12 4.6e-14 1.2e-14 7.4e-15
6 NAcc mRNA stability Dbi 0.43 0.01 0.0e+00 0.23 0.22 0.22 0.23 6.1e-35 3.5e-32 1.6e-33 3.6e-34
7 Adipose mRNA stability Dbi 0.08 0.05 6.5e-03 0.02 -0 0.01 0.01 2.1e-03 3.8e-01 5.5e-02 1.1e-02
8 pVTA gene expression Dbi 0.18 0.09 5.3e-05 0.05 0.04 0.04 0.05 4.2e-05 4.5e-04 1.7e-04 1.0e-04
9 Brain mRNA stability Dbi 0.58 0.12 0.0e+00 0.4 0.39 0.41 0.42 2.1e-39 3.3e-38 4.1e-41 9.2e-42
10 pVTA mRNA stability Dbi 0.39 0.02 0.0e+00 0.38 0.41 0.41 0.42 1.0e-31 8.9e-36 7.2e-35 5.6e-36
11 Eye mRNA stability Dbi 0.51 0.19 5.6e-04 0.07 0.11 0.06 0.12 2.9e-02 9.1e-03 4.5e-02 5.8e-03
12 Brain gene expression Dbi 0.47 0.11 0.0e+00 0.31 0.29 0.32 0.32 7.7e-30 1.7e-27 6.5e-30 1.3e-30
13 Liver gene expression Dbi 0.1 0.06 5.9e-07 0.04 0.04 0.04 0.04 8.0e-06 3.6e-05 1.0e-05 1.1e-05
14 IC gene expression Dbi 0.26 0.1 7.8e-05 0.06 0.04 0.07 0.08 1.8e-03 1.1e-02 6.3e-04 3.0e-04
15 OFC gene expression Dbi 0.54 0.16 3.4e-04 0.18 0.1 0.14 0.17 4.0e-05 1.9e-03 3.3e-04 7.3e-05
16 IC mRNA stability Dbi 0.79 0.05 0.0e+00 0.39 0.35 0.4 0.39 2.6e-17 1.9e-15 7.0e-18 2.5e-17
17 PL gene expression Dbi 0.26 0.08 3.1e-14 0.09 0.11 0.12 0.12 8.9e-10 1.9e-12 3.1e-13 1.4e-12
18 Eye gene expression Dbi 0.33 0.17 4.0e-03 0.12 0.07 0.04 0.06 8.0e-03 3.0e-02 7.3e-02 4.3e-02
19 BLA gene expression Dbi 0.25 0.1 5.0e-07 0.07 0.08 0.07 0.08 1.1e-04 3.5e-05 1.2e-04 5.0e-05
20 PL mRNA stability Dbi 0.3 0.03 0.0e+00 0.28 0.3 0.3 0.3 7.8e-31 2.1e-33 4.4e-33 1.9e-32
21 RMTg mRNA stability Dbi 0.17 0.11 5.1e-03 0.03 0.05 0.05 0.03 5.5e-02 2.3e-02 2.2e-02 4.8e-02
22 LHb gene expression Dbi 0.22 0.13 7.7e-03 0.09 0.01 0.06 0.07 4.6e-03 1.6e-01 1.7e-02 8.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.81.33.8-0.9-1.50.11.01.0-1.0-1.01.0-1.3-1.1-1.91.20.61.1-0.3-1.10.82.01.5-1.2-1.60.0
Area under the delay curve0.91.06.10.90.1-0.4-1.3-1.10.1-0.30.31.00.51.2-0.8-2.5-1.2-0.00.6-1.8-0.9-1.41.2-0.30.0
BMI with tail2.07.012.93.32.6-3.6-3.3-2.93.13.1-3.13.03.01.1-2.9-1.7-2.6-2.82.5-2.9-0.3-2.72.40.80.0
BMI without tail0.92.75.02.01.5-2.2-2.1-1.82.01.6-1.61.91.80.6-1.8-1.0-1.7-1.91.6-1.9-0.1-1.91.60.50.0
Body weight0.41.75.21.81.1-2.3-1.8-1.31.51.7-1.71.41.4-0.0-1.2-0.1-0.9-1.70.8-1.40.7-1.40.8-0.20.0
Weight adjusted by age0.40.62.70.60.7-0.9-0.8-1.1-0.00.7-0.70.50.50.2-0.4-1.6-1.1-0.80.7-1.20.2-1.10.5-0.20.0
Bone surface0.30.51.50.50.8-1.2-0.5-0.60.51.1-1.10.30.6-0.6-0.30.2-0.4-1.00.5-0.90.7-0.30.6-0.60.0
Bone volume0.20.41.9-0.6-0.7-0.00.50.5-0.8-0.40.4-0.8-0.6-1.20.80.10.5-0.1-0.6-0.11.10.6-0.3-1.40.0
Breakpoint value in progressive ratio session0.30.42.50.20.10.1-0.4-0.50.20.0-0.00.60.50.9-0.6-1.6-0.80.50.5-0.9-1.0-0.70.6-0.30.0
Number of licking bursts0.30.65.10.50.2-0.1-0.7-0.60.1-0.10.10.60.41.0-0.6-2.3-0.90.10.6-1.0-1.0-0.40.8-0.20.0
Context. condit. distance diff. score0.40.42.60.60.50.1-0.6-0.60.10.1-0.10.50.21.3-0.4-1.0-0.50.30.4-0.3-1.6-0.90.61.00.0
Locomotion velocity, session 12.22.46.21.21.6-0.5-1.5-1.60.91.1-1.11.61.32.2-1.3-2.3-1.70.21.5-2.5-1.6-2.52.20.30.0
Locomotion distance, session 10.40.52.5-0.20.20.8-0.1-0.3-0.5-0.30.30.2-0.11.4-0.0-1.6-0.50.90.1-1.1-0.8-1.10.6-0.60.0
Locomotion velocity, session 20.50.62.1-1.4-0.90.91.10.8-0.9-0.60.6-0.5-0.6-0.80.6-0.70.21.2-0.5-0.20.7-0.4-0.1-1.50.0
Locomotion distance, session 20.20.32.3-0.6-0.50.40.40.2-0.2-0.50.50.0-0.1-0.1-0.1-1.3-0.30.6-0.0-0.70.6-0.20.1-1.50.0
Locomotion velocity, session 30.30.40.9-0.2-0.40.90.30.5-0.8-0.50.5-0.6-0.70.70.70.90.80.5-0.70.9-0.80.0-0.50.40.0
Locomotion distance, session 30.40.53.40.2-0.1-0.80.10.2-0.00.3-0.3-0.4-0.2-0.80.51.80.6-1.4-0.50.61.20.4-0.6-0.20.0
Stereotopy head waving bouts, day 30.40.41.3-0.3-1.10.30.40.7-0.8-0.90.9-0.9-0.8-0.60.80.10.80.0-0.50.70.60.8-0.5-0.50.0
Stereotopy head waving duration, day 30.20.31.40.1-0.20.8-0.10.1-0.4-0.60.6-0.1-0.31.10.2-0.70.20.80.10.2-1.2-0.10.30.50.0
Locomotion velocity, session 70.70.74.50.11.01.00.1-0.0-0.10.4-0.4-0.1-0.11.50.31.10.31.4-0.10.5-1.6-0.70.42.10.0
Locomotion distance, session 70.10.11.30.10.00.2-0.10.00.00.1-0.1-0.0-0.00.30.10.20.20.6-0.10.3-0.3-0.10.11.10.0
Stereotopy head waving bouts, day 70.50.61.4-0.8-0.91.00.70.9-0.8-0.90.9-0.7-0.8-0.10.7-0.10.80.7-0.90.7-0.30.9-1.2-0.80.0
Stereotopy head waving duration, day 70.10.11.0-0.10.00.70.10.2-0.2-0.30.3-0.0-0.20.70.1-0.30.20.5-0.3-0.1-1.00.1-0.4-0.50.0
Locomotion velocity, session 80.91.04.90.0-0.11.5-0.00.2-1.1-1.01.0-0.5-0.82.00.7-0.10.51.8-0.50.7-2.2-0.40.21.50.0
Locomotion distance, session 80.10.21.2-0.1-0.40.6-0.1-0.0-0.5-0.60.6-0.1-0.30.80.2-1.1-0.10.7-0.2-0.1-0.6-0.20.0-0.30.0
Degree of sensitization distance0.40.42.50.10.10.4-0.3-0.30.1-0.00.00.40.20.7-0.4-1.6-0.51.30.4-0.6-1.0-0.50.70.70.0
Degree of sensitization stereotypy1.01.12.7-1.0-1.21.31.01.1-1.0-1.21.2-1.0-1.1-0.31.00.31.10.8-1.31.1-0.11.3-1.6-1.00.0
Conditioned locomotion0.00.00.20.1-0.20.1-0.1-0.00.0-0.40.40.1-0.10.2-0.0-0.4-0.0-0.1-0.1-0.1-0.1-0.10.1-0.20.0
Cocaine response after cond. corrected3.94.710.22.62.2-1.1-2.6-2.32.21.6-1.62.52.23.2-2.4-1.8-2.2-0.62.5-1.5-2.9-2.12.42.70.0
Cocaine response after cond. not corrected4.35.014.02.82.2-0.7-2.7-2.32.01.4-1.42.42.03.7-2.3-1.9-2.1-0.32.3-1.4-3.4-2.32.53.20.0
Cocaine response before conditioning0.20.20.60.0-0.60.60.00.4-0.6-0.70.7-0.5-0.70.20.60.20.70.2-0.80.4-0.20.3-0.20.50.0
Saline control response0.50.72.0-0.8-1.11.30.70.8-1.1-1.21.2-0.7-0.90.00.7-0.50.61.4-0.80.6-0.30.7-0.5-0.30.0
Bone: connectivity density0.30.41.80.1-0.2-0.90.10.20.30.3-0.3-0.30.1-1.30.11.20.4-1.3-0.20.51.41.0-0.7-0.30.0
Bone: cortical apparent density1.82.56.0-1.4-2.51.31.41.6-1.8-2.32.3-1.8-1.8-1.41.6-0.31.40.4-1.51.81.22.1-1.7-0.60.0
Bone: cortical area0.91.42.6-1.1-0.91.41.31.4-1.3-1.11.1-1.4-1.4-0.51.51.51.61.1-1.51.50.21.1-1.2-0.10.0
Bone: cortical porosity0.10.11.20.40.3-0.5-0.3-0.20.10.3-0.3-0.2-0.0-0.20.21.10.2-0.2-0.20.00.30.1-0.10.10.0
Bone: cortical porosity0.10.10.60.40.4-0.2-0.2-0.20.10.5-0.5-0.00.10.20.10.70.10.2-0.1-0.3-0.2-0.20.10.10.0
Bone: cortical thickness1.01.73.0-1.3-1.11.41.41.5-1.4-1.11.1-1.6-1.5-0.71.61.61.71.1-1.51.70.21.4-1.30.10.0
Bone: cortical thickness2.73.15.8-1.5-2.01.51.71.9-2.2-1.81.8-2.4-2.2-1.32.31.42.20.8-2.12.11.22.1-1.9-0.30.0
Bone: cortical tissue density1.72.35.8-1.3-2.41.21.31.5-1.7-2.32.3-1.7-1.7-1.31.5-0.51.30.3-1.41.71.12.0-1.6-0.70.0
Condit. Reinf. active minus inactive responses0.20.31.40.6-0.2-1.2-0.5-0.30.10.1-0.1-0.00.1-0.8-0.00.1-0.1-1.1-0.1-0.21.10.1-0.0-0.50.0
Condit. Reinf. active-inactive response ratio0.10.10.30.1-0.20.10.00.2-0.4-0.30.3-0.4-0.40.00.50.40.50.2-0.50.50.10.4-0.5-0.00.0
Condit. Reinf. active responses0.40.52.30.5-0.1-1.5-0.5-0.60.50.5-0.50.40.6-1.2-0.5-0.5-0.7-1.30.5-0.51.4-0.10.3-0.50.0
Condit. Reinf. inactive responses0.50.61.60.3-0.1-1.3-0.4-0.60.70.6-0.60.60.8-1.2-0.8-1.0-1.0-1.01.0-0.61.2-0.20.5-0.40.0
Incentive salience index mean0.40.53.80.1-0.6-1.2-0.0-0.1-0.10.1-0.1-0.3-0.0-1.60.20.30.0-1.3-0.20.01.90.4-0.2-0.80.0
Condit. Reinf. lever presses0.30.42.9-0.2-0.5-0.90.2-0.1-0.00.4-0.4-0.30.1-1.50.10.1-0.2-1.00.20.11.70.4-0.1-0.70.0
Condit. Reinf. active minus inactive responses5.16.510.82.83.3-3.0-2.8-3.02.73.3-3.32.72.91.6-2.6-1.2-2.7-2.42.6-3.0-0.9-2.72.60.80.0
Condit. Reinf. active-inactive response ratio5.15.99.62.32.9-2.6-2.4-2.82.42.8-2.82.72.71.5-2.6-2.0-2.8-1.92.8-3.1-1.1-2.82.70.40.0
Condit. Reinf. active responses3.95.49.72.72.8-3.1-2.7-2.72.33.1-3.12.22.51.1-2.1-0.9-2.3-2.52.1-2.8-0.1-2.52.30.50.0
Condit. Reinf. inactive responses0.40.52.60.90.2-1.4-0.7-0.40.30.8-0.8-0.20.2-0.80.10.90.2-1.6-0.3-0.11.50.3-0.2-0.00.0
Condit. Reinf. lever presses0.30.41.11.00.6-1.1-0.9-0.60.20.7-0.70.20.30.2-0.10.8-0.1-0.6-0.1-0.70.3-0.70.5-0.90.0
Condit. Reinf. lever reinforcers received3.54.89.22.72.6-3.0-2.7-2.62.12.9-2.92.22.41.0-2.0-0.9-2.1-2.41.9-2.7-0.2-2.42.20.40.0
Conditioned reinforcement - actives0.20.30.90.50.3-0.7-0.6-0.50.6-0.10.10.60.40.4-0.7-0.8-0.6-0.50.6-0.8-0.5-0.41.0-0.10.0
Conditioned reinforcement - inactives0.40.62.6-1.4-0.60.31.30.8-0.3-0.50.5-0.5-0.4-1.60.40.20.30.4-0.30.41.30.7-0.6-1.00.0
Conditioned locomotion0.81.12.8-1.4-1.21.11.31.0-1.1-0.90.9-1.1-0.9-1.01.0-0.10.81.7-0.80.80.71.1-0.9-1.30.0
Patch foraging indifference point 0 sec1.52.87.7-1.7-1.72.81.72.0-1.6-2.12.1-1.5-1.90.21.61.21.92.0-1.91.9-0.71.4-1.5-0.50.0
Patch foraging indifference point AUC0.10.21.0-0.7-0.60.00.50.3-0.5-0.10.1-0.3-0.2-0.80.2-0.70.00.1-0.2-0.00.80.2-0.3-1.00.0
Delay disc. indifference point, 0s delay0.40.42.3-1.0-0.80.70.60.4-0.7-0.60.6-0.2-0.4-0.50.3-1.5-0.11.1-0.2-0.50.2-0.1-0.0-0.90.0
Delay disc. indifference point, 16s delay3.53.97.72.21.4-2.2-2.5-2.41.81.0-1.02.41.91.5-2.3-2.8-2.5-1.71.9-2.7-0.8-2.42.20.60.0
Delay disc. indifference point, 2s delay1.51.74.8-1.5-1.22.21.31.3-1.8-1.51.5-1.3-1.60.61.4-0.31.22.2-1.50.5-0.80.5-0.6-0.20.0
Delay disc. indifference point, 24s delay0.30.31.20.5-0.9-0.4-0.6-0.3-0.1-0.90.90.1-0.2-0.3-0.1-0.9-0.2-0.3-0.3-0.50.7-0.0-0.2-1.10.0
Delay disc. indifference point, 4s delay0.40.42.60.4-0.4-0.1-0.7-0.6-0.5-0.60.60.2-0.20.6-0.1-1.6-0.60.2-0.0-1.2-0.6-0.90.8-0.90.0
Delay disc. indifference point, 8s delay0.50.64.20.7-0.10.1-0.9-0.8-0.1-0.40.40.60.21.2-0.5-2.0-0.80.40.3-1.2-0.9-0.90.8-0.30.0
Indifference point function ln k0.20.41.40.70.90.1-0.6-0.51.00.4-0.40.80.61.2-0.70.6-0.30.30.3-0.3-0.8-0.50.20.50.0
Indifference point function log k0.20.41.40.70.90.1-0.6-0.51.00.4-0.40.80.61.2-0.70.6-0.30.30.3-0.3-0.8-0.50.20.50.0
Patch foraging total patch changes 0 sec1.22.26.3-1.6-1.62.51.61.8-1.4-1.91.9-1.3-1.60.21.40.91.71.8-1.71.5-0.61.2-1.3-0.70.0
Patch foraging total patch changes 12 sec2.02.65.1-2.0-2.02.22.02.1-1.9-1.81.8-1.7-1.8-0.81.70.31.81.8-1.51.7-0.11.6-1.3-0.90.0
Patch foraging total patch changes 18 sec1.21.94.8-1.9-1.52.21.91.8-1.4-1.51.5-1.3-1.4-0.51.20.11.31.9-1.21.4-0.11.4-1.1-0.50.0
Patch foraging total patch changes 24 sec0.50.93.8-1.1-0.61.91.11.2-0.8-0.80.8-0.7-0.90.50.80.71.11.5-1.01.1-1.10.7-0.60.30.0
Patch foraging total patch changes 6 sec1.11.74.5-1.4-1.72.11.41.5-1.6-1.71.7-1.3-1.5-0.01.3-0.01.31.8-1.21.4-0.41.2-0.9-0.50.0
Patch foraging time to switch 0 sec0.20.41.00.50.5-0.7-0.6-0.70.30.5-0.50.50.50.1-0.5-1.0-0.8-0.30.8-0.9-0.1-0.71.00.30.0
Patch foraging water rate 0 sec0.40.72.60.2-0.01.2-0.00.6-0.4-0.30.3-0.5-0.71.60.71.41.21.0-1.11.0-1.60.3-0.80.70.0
Patch foraging water rate 12 sec0.10.21.5-0.20.30.00.30.20.00.5-0.5-0.3-0.1-0.10.31.20.4-0.6-0.60.5-0.10.6-0.80.10.0
Patch foraging water rate 18 sec0.40.61.4-0.3-0.21.10.50.7-0.6-0.60.6-0.7-0.80.90.81.20.90.2-0.71.2-1.10.6-0.61.00.0
Patch foraging water rate 24 sec0.30.42.31.20.6-0.2-1.0-0.60.10.3-0.30.20.11.5-0.10.3-0.1-0.4-0.00.0-1.1-0.40.10.90.0
Patch foraging water rate 6 sec0.20.33.10.30.20.20.00.40.10.0-0.0-0.3-0.30.40.41.80.9-0.1-0.80.7-0.40.8-1.00.10.0
Seeking ratio, delayed vs. immediate footshock0.30.31.80.30.50.5-0.3-0.20.00.0-0.00.20.11.2-0.10.0-0.11.00.30.1-1.2-0.30.81.30.0
Distance traveled before self-admin0.30.41.4-1.1-0.61.00.90.4-0.9-0.30.3-0.5-0.4-0.20.5-1.00.01.2-0.50.1-0.10.1-0.4-0.40.0
Distance traveled after self-admin1.92.46.7-2.6-1.41.92.51.7-1.8-1.31.3-1.8-1.5-1.61.60.31.22.0-1.31.30.81.5-1.3-0.40.0
Extensor digitorum longus weight0.72.77.3-1.6-2.70.71.31.6-1.9-2.32.3-1.6-1.8-2.21.6-0.71.30.6-1.51.01.81.4-1.4-2.00.0
Bone: elastic displacement0.20.20.80.70.5-0.6-0.6-0.50.50.5-0.50.40.40.4-0.40.1-0.3-0.90.3-0.5-0.2-0.20.40.00.0
Bone: elastic work1.11.42.7-0.9-1.01.51.01.2-1.5-1.31.3-1.5-1.50.11.51.31.51.2-1.31.6-0.41.0-1.00.00.0
Bone: endosteal estimation0.00.10.20.10.20.2-0.1-0.0-0.1-0.10.10.0-0.10.40.10.10.10.5-0.1-0.3-0.5-0.40.3-0.30.0
Bone: endosteal perimeter0.10.20.60.30.5-0.1-0.4-0.40.10.3-0.30.40.30.5-0.3-0.7-0.40.20.3-0.7-0.3-0.70.5-0.30.0
Epididymis fat weight2.38.012.13.03.2-3.4-3.2-3.32.93.5-3.53.13.31.4-3.1-2.4-3.3-2.83.2-2.9-0.9-2.72.60.80.0
Delta time in closed arm before/after self-admin3.02.86.62.11.3-1.1-2.1-1.81.31.1-1.11.61.52.6-1.8-2.2-1.7-0.71.8-1.3-2.3-0.91.92.30.0
Delta time in open arm before/after self-admin3.03.07.4-2.1-2.11.21.91.8-2.1-1.51.5-1.8-1.8-2.31.90.21.61.2-1.90.91.81.1-2.0-2.70.0
Diff in mean of infusions in LGA sessions0.30.41.50.40.40.5-0.20.2-0.5-0.20.2-0.5-0.61.10.61.10.80.2-0.50.5-1.20.0-0.21.00.0
Delay discount exponential model param0.80.95.0-0.9-0.10.31.21.0-0.10.3-0.3-0.9-0.4-1.20.72.21.1-0.1-0.51.61.01.3-1.20.30.0
Extinction: sum of active levers before priming0.10.10.6-0.7-0.20.30.60.4-0.0-0.10.1-0.1-0.0-0.80.0-0.40.10.7-0.1-0.00.60.3-0.3-0.30.0
Active lever presses in extinction session 60.90.93.5-1.5-1.00.91.31.0-0.8-0.40.4-0.7-0.6-1.30.7-0.00.61.1-0.70.31.00.6-1.0-1.90.0
Bone: final force1.52.44.5-1.5-1.11.91.71.6-1.8-1.31.3-1.9-1.9-0.52.02.11.92.0-1.91.70.00.9-1.3-0.20.0
Bone: final moment1.42.34.5-1.5-1.01.91.61.6-1.8-1.41.4-1.8-1.8-0.42.02.11.92.0-1.91.6-0.10.9-1.2-0.20.0
Food consumed during 24 hour testing period0.10.10.60.20.1-0.2-0.3-0.20.10.3-0.30.20.2-0.0-0.2-0.5-0.2-0.20.0-0.8-0.0-0.20.2-0.30.0
Glucose3.55.510.12.42.5-2.5-2.6-2.72.22.6-2.62.72.61.4-2.6-2.3-2.8-1.62.5-3.2-1.1-2.82.5-0.10.0
Heart weight0.40.62.21.50.7-1.4-1.3-1.01.10.6-0.60.80.80.3-0.90.3-0.6-1.00.6-0.30.1-0.20.10.00.0
Delay discount hyperbolic model param0.70.84.6-0.70.00.01.00.80.10.4-0.4-0.7-0.2-1.40.52.10.9-0.4-0.31.51.31.2-1.10.20.0
Intermittent access intake day 1-15 change0.30.54.1-1.00.90.11.20.60.70.7-0.70.10.2-1.1-0.12.00.40.50.20.50.70.1-0.60.10.0
Intermittent access intake escalation0.30.64.0-1.30.50.61.40.90.20.3-0.3-0.4-0.3-0.90.42.00.70.9-0.20.90.50.5-0.90.20.0
Intermittent access intake escalation 20.20.21.1-0.50.80.30.60.30.70.4-0.40.30.30.1-0.31.00.10.60.40.4-0.30.1-0.20.80.0
Intermitt. access day 1 inactive lever presses0.82.98.1-2.3-1.90.72.22.0-1.5-1.41.4-1.6-1.5-2.81.61.01.50.4-1.31.32.41.6-1.7-2.30.0
Intermitt. access day 15 inactive lever presses0.30.54.1-1.2-0.4-0.41.10.4-0.1-0.20.2-0.4-0.2-2.00.30.5-0.0-0.5-0.10.11.70.4-0.4-0.80.0
Intermitt. access escalation Index0.30.41.10.2-1.00.0-0.20.1-0.9-0.70.7-0.7-0.7-0.10.6-0.80.4-0.4-0.80.10.50.6-1.1-0.80.0
Intermittent access day 1 total infusions0.10.10.80.5-0.3-0.4-0.5-0.3-0.3-0.30.3-0.2-0.10.40.1-0.9-0.1-0.60.1-0.2-0.30.20.50.40.0
Intermittent access day 15 total infusions0.30.40.9-0.6-0.40.40.80.7-0.6-0.50.5-0.9-0.8-0.70.90.90.90.3-0.50.80.40.9-0.60.30.0
Intermittent access terminal intake (last 3 days)0.20.20.5-0.3-0.30.30.40.5-0.6-0.50.5-0.7-0.7-0.10.70.40.70.5-0.50.5-0.10.6-0.40.10.0
Intermittent access total infusions0.00.10.20.3-0.1-0.4-0.2-0.2-0.2-0.20.2-0.3-0.2-0.10.2-0.50.0-0.40.1-0.10.20.40.30.10.0
Intermittent access day 1 locomotion1.62.05.5-1.2-1.91.21.11.2-2.3-1.81.8-1.9-1.9-0.71.9-0.31.41.3-1.61.10.41.2-1.2-0.90.0
Intermittent access day 15 total locomotion0.30.51.8-0.9-0.61.00.90.8-0.8-0.90.9-0.7-0.8-0.00.7-0.00.61.3-0.40.7-0.30.7-0.4-0.10.0
Intermittent access total locomotion0.60.82.7-1.3-0.81.21.20.9-1.1-0.90.9-1.0-0.9-0.40.9-0.30.71.7-0.60.60.00.8-0.7-0.60.0
Intermittent access standard deviation0.10.21.8-0.50.50.40.50.20.50.2-0.20.30.3-0.2-0.30.3-0.11.40.60.1-0.0-0.20.20.80.0
Left kidney weight0.52.410.6-1.7-2.70.51.21.4-1.0-1.61.6-0.7-0.8-2.70.6-2.00.50.6-1.1-0.42.51.0-0.8-3.30.0
Right kidney weight0.62.88.2-1.9-2.90.91.51.8-1.5-2.02.0-1.1-1.4-2.51.1-0.91.21.2-1.70.52.31.1-1.5-2.80.0
Cocaine induced anxiety0.81.24.3-0.01.3-0.90.0-0.62.11.5-1.51.61.6-0.6-1.60.5-1.2-0.61.0-1.00.7-0.90.40.10.0
Post-drug Anxiety0.60.62.20.11.1-0.6-0.1-0.61.51.3-1.31.01.2-0.4-1.10.5-0.9-0.50.9-0.50.5-0.40.20.30.0
Baseline Anxiety0.20.20.80.4-0.60.2-0.30.0-0.9-0.30.3-0.8-0.6-0.00.70.10.5-0.2-0.40.50.30.7-0.4-0.20.0
Tail length0.20.71.4-0.7-0.60.90.70.8-0.8-0.90.9-0.9-1.0-0.31.01.21.01.0-1.10.90.30.5-1.0-0.50.0
Length with tail0.10.30.8-0.4-0.50.50.40.6-0.6-0.50.5-0.5-0.6-0.30.70.60.80.7-0.90.40.40.1-0.7-0.80.0
Length without tail0.00.10.20.40.0-0.1-0.30.2-0.10.3-0.3-0.1-0.10.30.20.40.50.3-0.20.4-0.1-0.0-0.00.00.0
Times rat made contact with spout0.80.91.4-1.2-0.90.81.21.1-1.0-1.01.0-1.1-1.0-1.01.00.71.00.7-1.00.80.71.1-0.8-0.60.0
Lifetime Intake0.10.10.40.1-0.3-0.3-0.1-0.1-0.4-0.40.4-0.4-0.3-0.30.2-0.60.0-0.10.1-0.10.20.40.3-0.00.0
Liver weight, left0.71.15.3-1.4-0.90.31.31.1-0.6-0.50.5-0.9-0.8-2.31.00.80.90.5-1.00.51.80.9-1.0-1.40.0
Liver weight, right0.20.31.10.1-1.10.1-0.20.1-0.4-1.01.0-0.2-0.5-0.70.3-1.10.1-0.2-0.4-0.20.40.2-0.1-0.50.0
Locomotor activity0.40.62.10.3-0.4-1.3-0.5-0.30.40.4-0.40.60.5-1.2-0.5-1.3-0.5-0.90.2-1.11.4-0.70.2-0.70.0
Locomotor testing distance0.20.42.0-0.1-0.4-0.8-0.2-0.20.30.3-0.30.60.5-0.9-0.5-1.4-0.6-0.30.2-1.21.1-0.80.4-0.90.0
Locomotor testing rearing0.20.42.0-0.8-1.20.00.60.6-0.4-0.60.6-0.3-0.3-1.30.3-0.60.2-0.1-0.30.11.40.3-0.6-1.00.0
Locomotion in novel chamber0.60.81.8-0.6-1.01.10.70.9-0.7-1.11.1-0.9-0.90.10.80.40.90.7-1.20.70.31.3-1.4-0.60.0
Locomotion in novel chamber post-restriction0.10.10.6-0.4-0.40.30.30.2-0.5-0.50.5-0.4-0.3-0.20.3-0.60.0-0.20.0-0.00.60.4-0.2-0.80.0
Fecal boli incidents, locomotor time 12.13.05.61.81.5-2.4-1.9-2.11.61.8-1.81.82.00.3-1.9-2.0-2.2-2.32.1-1.7-0.0-1.31.70.90.0
Change in fecal boli incidents, locomotor task2.72.65.0-1.5-1.51.01.71.7-1.4-1.41.4-1.8-1.6-1.71.71.91.80.1-1.91.52.12.2-2.1-1.40.0
Time >=10cm from walls, locomotor time 10.30.31.4-0.10.2-1.00.20.20.10.5-0.5-0.20.1-0.90.20.70.3-1.10.00.31.20.2-0.3-0.20.0
Bouts of movement, locomotor time 10.10.10.5-0.1-0.50.2-0.0-0.2-0.2-0.30.30.0-0.1-0.2-0.1-0.7-0.30.10.1-0.40.6-0.20.2-0.40.0
Total resting periods, locomotor time 10.10.10.90.2-0.4-0.2-0.3-0.40.1-0.10.10.20.1-0.3-0.2-0.3-0.4-0.30.1-0.51.0-0.20.1-0.60.0
Rest time, locomotor task time 11.01.22.31.11.2-1.2-1.1-1.31.51.2-1.21.31.20.3-1.20.1-1.2-1.50.9-1.30.5-1.11.00.50.0
Distance moved, locomotor task time 10.81.23.6-1.6-1.01.71.31.2-1.2-1.51.5-0.7-1.00.30.7-1.30.61.9-0.60.5-1.30.4-0.3-0.30.0
Vertical activity count, locomotor time 11.22.86.6-2.1-1.62.22.02.0-2.2-1.81.8-1.9-1.90.01.8-0.71.62.6-1.41.7-0.81.5-1.6-0.60.0
Time >=10cm from walls, locomotor time 20.30.52.30.00.7-0.90.2-0.00.61.0-1.00.00.4-1.0-0.11.50.2-0.70.40.51.30.2-0.30.60.0
Bouts of movement, locomotor time 20.91.54.31.00.6-1.0-1.2-1.21.30.7-0.71.61.30.6-1.6-2.1-1.5-0.51.5-1.7-0.8-1.51.80.10.0
Total resting periods, locomotor time 20.91.65.50.90.5-1.1-1.2-1.21.30.7-0.71.61.40.2-1.6-2.4-1.7-0.71.6-1.9-0.4-1.51.9-0.30.0
Rest time, locomotor task time 20.30.31.60.70.2-1.0-0.7-0.70.20.2-0.20.40.3-0.3-0.3-0.1-0.5-1.30.3-0.80.8-0.60.5-0.50.0
Distance moved, locomotor task time 21.01.23.9-2.0-0.91.81.81.4-0.9-1.21.2-0.7-0.9-0.10.7-0.50.71.9-0.90.5-0.50.6-0.9-0.70.0
Vertical activity count, locomotor time 20.30.41.5-0.8-0.31.00.70.5-0.6-0.50.5-0.5-0.50.40.5-0.80.21.2-0.30.4-0.60.4-0.7-0.00.0
Light reinforcement 10.30.64.5-0.0-0.5-1.2-0.0-0.10.60.3-0.30.40.4-1.8-0.40.3-0.3-1.20.2-0.52.1-0.00.0-1.10.0
Light reinforcement 20.91.33.50.91.3-1.9-0.6-1.01.61.7-1.70.91.3-0.9-1.01.4-0.8-1.71.1-0.51.4-0.40.30.00.0
Bone: marrow area0.00.10.30.00.20.4-0.00.1-0.2-0.20.2-0.1-0.30.40.20.30.30.6-0.3-0.1-0.5-0.30.2-0.20.0
Bone: maximum diameter0.20.30.7-0.8-0.50.70.70.7-0.8-0.50.5-0.7-0.7-0.50.80.20.70.7-0.60.50.40.3-0.5-0.40.0
Bone: maximum force2.34.17.2-1.9-1.42.72.02.1-2.5-2.02.0-2.4-2.5-0.32.62.52.52.7-2.52.3-0.51.1-1.60.10.0
Bone: maximum moment2.13.77.0-1.7-1.42.61.92.0-2.4-1.91.9-2.2-2.4-0.22.52.42.42.7-2.42.2-0.61.0-1.50.10.0
Mean time between licks in bursts1.22.85.92.42.0-2.2-2.1-1.91.81.8-1.81.51.71.5-1.6-0.2-1.4-2.41.9-0.5-1.0-0.61.22.40.0
Mean num. licks in bursts0.81.36.0-1.2-0.80.61.41.2-0.7-0.50.5-1.2-1.0-1.61.22.51.30.4-1.11.31.31.0-1.1-0.40.0
Cd content in liver0.00.00.10.30.1-0.2-0.3-0.20.2-0.10.10.30.20.2-0.3-0.1-0.20.00.30.2-0.3-0.30.20.20.0
Co content in liver1.41.64.71.52.1-1.3-0.9-0.81.81.9-1.90.81.20.8-0.92.2-0.3-1.21.00.3-0.60.20.52.10.0
Cu content in liver5.16.010.9-2.6-2.62.22.92.9-2.2-2.02.0-2.8-2.4-2.32.62.72.81.4-2.53.22.23.3-2.9-0.60.0
Fe content in liver0.20.21.00.20.10.3-0.1-0.0-0.7-0.50.5-0.6-0.60.60.60.70.4-0.1-0.10.8-0.80.10.11.00.0
K content in liver0.20.21.2-0.5-0.2-0.10.50.30.10.3-0.3-0.10.0-0.90.10.80.2-0.0-0.40.31.10.2-0.40.20.0
Mg content in liver0.10.10.9-0.10.2-0.10.20.00.20.5-0.5-0.10.1-0.30.00.90.10.3-0.20.20.50.1-0.30.30.0
Mn content in liver1.21.32.3-1.3-1.20.71.31.1-1.4-0.60.6-1.4-1.2-1.41.41.21.20.2-1.41.11.50.8-1.2-0.80.0
Na content in liver2.62.85.61.42.0-2.2-1.4-1.82.02.4-2.41.82.00.1-1.8-0.3-1.8-2.01.8-1.60.3-1.61.51.10.0
Rb content in liver1.31.53.81.31.9-1.2-0.9-0.91.71.8-1.81.01.20.9-1.01.9-0.5-0.81.00.0-0.4-0.50.82.00.0
Se content in liver0.20.31.20.6-0.0-1.0-0.6-0.60.50.3-0.30.30.4-0.4-0.4-0.1-0.5-1.10.5-0.21.0-0.20.20.40.0
Sr content in liver1.51.32.51.01.1-1.5-1.1-1.21.31.6-1.61.21.40.2-1.2-0.8-1.3-1.51.2-1.60.2-1.00.9-0.40.0
Zn content in liver0.30.31.5-0.4-0.5-0.60.30.10.50.1-0.10.30.4-1.2-0.5-0.7-0.40.10.4-0.21.10.5-0.3-0.80.0
Bone: minimum diameter0.20.32.4-0.20.00.60.40.5-0.4-0.30.3-0.5-0.60.10.71.60.90.5-0.90.5-0.20.2-0.4-0.00.0
Time in familiar zone, hab. session 11.31.23.91.11.4-0.2-1.0-1.00.90.6-0.61.10.92.0-1.1-0.6-0.90.21.1-0.7-2.0-1.01.31.90.0
Time in novel zone, hab. session 10.90.94.5-0.7-1.2-0.40.70.7-0.4-0.40.4-0.7-0.5-2.10.60.40.5-0.7-0.40.62.11.1-0.9-1.50.0
Total zone transitions, hab. session 10.10.10.8-0.5-0.00.70.30.2-0.2-0.10.1-0.1-0.20.30.2-0.40.10.8-0.5-0.5-0.2-0.2-0.1-0.90.0
Total locomotion distance, hab. session 10.20.31.1-0.8-0.90.70.60.5-0.5-0.80.8-0.3-0.4-0.30.3-1.00.20.9-0.4-0.20.20.2-0.2-0.80.0
Locomotion velocity, hab. session 10.40.61.5-1.0-1.11.10.80.8-0.9-1.01.0-0.6-0.8-0.30.6-0.80.51.2-0.80.10.10.4-0.4-0.90.0
Time in familiar zone, hab. session 22.22.311.11.51.90.1-1.4-1.21.00.7-0.71.30.92.9-1.1-0.5-0.90.51.3-0.6-3.3-1.51.82.70.0
Time in novel zone, hab. session 21.41.48.4-0.8-1.6-0.50.80.7-0.7-0.60.6-0.9-0.6-2.20.80.20.6-0.8-0.90.32.91.2-1.4-2.40.0
Total zone transitions, hab. session 20.00.10.6-0.20.00.30.20.0-0.2-0.10.1-0.2-0.10.30.2-0.1-0.00.2-0.3-0.40.20.1-0.1-0.80.0
Total locomotion distance, hab. session 20.40.52.6-0.8-1.10.30.60.6-0.7-0.90.9-0.5-0.6-0.70.5-0.70.30.1-0.5-0.20.90.6-0.4-1.60.0
Locomotion velocity, hab. session 20.50.72.6-1.0-1.10.50.90.8-0.9-1.01.0-0.8-0.8-0.90.7-0.40.50.4-0.70.01.00.7-0.6-1.60.0
Novel to familiar place preference ratio0.40.42.9-0.4-0.6-0.70.20.1-0.50.1-0.1-0.3-0.2-1.40.4-0.60.1-0.8-0.3-0.61.30.1-0.5-1.70.0
Novelty place preference0.60.63.0-0.7-0.9-0.40.50.4-0.8-0.20.2-0.6-0.5-1.70.7-0.50.3-0.6-0.5-0.31.50.2-0.6-1.70.0
Time in novel zone, NPP test0.40.52.5-0.6-0.7-0.50.40.2-0.7-0.30.3-0.5-0.5-1.60.6-0.50.2-0.6-0.4-0.41.40.0-0.4-1.50.0
Total zone transitions, NPP test0.70.91.71.11.3-1.1-1.1-1.31.00.9-0.91.01.01.0-1.0-0.6-1.2-0.80.9-1.3-0.1-1.01.00.50.0
Total locomotion distance, NPP test0.40.52.6-0.2-1.1-0.50.10.2-0.3-0.90.9-0.3-0.3-1.00.2-0.80.0-0.8-0.2-0.21.60.7-0.3-1.30.0
Locomotion velocity, NPP test0.30.42.2-0.1-1.0-0.5-0.00.2-0.2-0.60.6-0.3-0.2-0.80.1-0.70.1-0.8-0.2-0.21.50.7-0.3-1.20.0
Intraocular pressure0.20.21.00.2-0.3-0.8-0.3-0.4-0.1-0.30.30.10.0-0.6-0.1-1.0-0.5-0.90.5-0.40.6-0.20.3-0.70.0
Delta distance traveled before/after self-admin0.70.81.8-1.2-0.50.91.31.1-0.9-0.50.5-1.1-1.0-0.81.11.31.11.0-0.81.00.30.9-0.60.40.0
Delta ambulatory time before/after self-admin0.81.02.0-1.3-0.80.91.41.2-1.1-0.80.8-1.2-1.2-1.21.20.91.20.8-0.90.90.81.0-0.8-0.20.0
Parametrial fat weight2.45.612.32.12.5-3.5-2.2-2.62.82.9-2.92.62.9-0.2-2.7-1.4-2.8-2.92.9-2.30.6-2.22.10.90.0
Pavlov. Cond. lever latency0.10.10.50.30.10.2-0.3-0.1-0.2-0.30.30.0-0.20.50.1-0.50.00.2-0.1-0.3-0.7-0.20.10.10.0
Pavlov. Cond. magazine entry latency0.20.20.70.20.8-0.5-0.1-0.30.50.7-0.70.40.50.1-0.40.5-0.3-0.10.60.2-0.2-0.40.30.80.0
Pavlov. Cond. change in total contacts0.30.31.7-0.10.1-0.80.2-0.00.30.6-0.6-0.00.3-1.3-0.00.7-0.0-0.80.30.21.20.00.1-0.00.0
Pavlov. Cond. index score0.10.20.60.00.6-0.30.1-0.10.50.7-0.70.30.4-0.0-0.30.8-0.2-0.10.40.3-0.0-0.10.20.70.0
Pavlov. Cond. latency score0.20.20.70.10.7-0.4-0.0-0.30.60.8-0.80.40.50.1-0.40.7-0.3-0.20.40.2-0.0-0.30.20.70.0
Pavlov. Cond. lever contacts0.20.20.9-0.5-0.4-0.00.60.4-0.10.1-0.1-0.4-0.2-0.80.30.90.3-0.1-0.30.80.80.5-0.6-0.20.0
Pavlov. Cond. magazine entry number0.10.10.90.1-0.60.2-0.20.0-0.2-0.60.6-0.0-0.20.00.0-0.9-0.0-0.1-0.2-0.40.2-0.0-0.0-0.50.0
Pavlov. Cond. intertrial magazine entries0.10.20.40.50.1-0.5-0.6-0.40.40.1-0.10.50.40.2-0.5-0.6-0.5-0.40.3-0.60.0-0.40.50.10.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.20.5-0.30.3-0.00.40.6-0.60.20.3-0.2-0.20.5-0.2-0.00.40.10.1-0.10.20.40.0
Pavlov. Cond. response bias0.10.10.3-0.30.2-0.40.30.10.20.4-0.4-0.00.2-0.6-0.10.5-0.0-0.10.20.30.40.2-0.00.10.0
Pavlov. Cond. lever latency0.20.31.9-0.60.20.80.60.20.1-0.30.3-0.0-0.00.3-0.1-0.3-0.10.90.50.5-0.70.20.11.40.0
Pavlov. Cond. magazine entry latency0.10.10.60.30.00.2-0.10.0-0.10.0-0.0-0.1-0.10.40.20.80.20.6-0.20.5-0.50.20.10.30.0
Pavlov. Cond. change in total contacts0.30.41.50.90.4-1.2-0.8-0.60.61.0-1.00.50.6-0.2-0.40.4-0.3-1.00.1-0.50.5-0.40.3-0.60.0
Pavlov. Cond. index score0.10.10.70.4-0.3-0.4-0.3-0.0-0.10.1-0.1-0.1-0.1-0.20.20.70.3-0.2-0.50.10.40.1-0.2-0.80.0
Pavlov. Cond. latency score0.10.21.30.1-0.40.0-0.00.3-0.30.0-0.0-0.4-0.3-0.30.51.20.60.3-0.70.50.40.3-0.4-0.60.0
Pavlov. Cond. lever contacts0.20.31.80.6-0.1-0.8-0.7-0.30.10.4-0.40.10.1-0.2-0.00.30.0-0.9-0.4-0.60.6-0.40.0-1.40.0
Pavlov. Cond. magazine entry number0.00.00.1-0.20.30.20.10.00.0-0.10.10.0-0.00.2-0.1-0.3-0.1-0.30.1-0.1-0.2-0.1-0.00.40.0
Pavlov. Cond. intertrial magazine entries1.11.73.31.21.8-1.4-1.2-1.41.51.5-1.51.51.51.0-1.5-0.6-1.4-1.01.5-1.4-0.7-1.51.40.80.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.5-0.2-0.3-0.4-0.1-0.00.2-0.2-0.0-0.0-0.10.10.60.2-0.1-0.40.00.20.0-0.1-0.70.0
Pavlov. Cond. response bias0.20.31.90.6-0.2-0.9-0.6-0.40.10.3-0.30.20.2-0.3-0.1-0.2-0.2-0.8-0.2-0.70.6-0.20.1-1.40.0
Time in closed arm before self-admin1.62.15.3-1.5-0.91.01.71.6-1.4-0.80.8-1.7-1.5-1.51.82.31.90.2-1.91.61.31.4-1.9-0.70.0
Time in closed arm after self-admin0.30.44.50.00.10.30.10.1-0.4-0.20.2-0.4-0.30.90.20.10.20.10.10.8-1.00.60.32.10.0
Time in open arm before self-admin2.42.64.92.01.8-1.1-2.0-1.71.61.3-1.31.81.52.2-1.7-0.8-1.4-0.71.5-1.5-1.9-1.92.11.80.0
Time in open arm after self-admin0.10.11.7-0.1-0.1-0.3-0.00.10.20.1-0.10.20.0-0.7-0.00.10.1-0.1-0.3-0.50.6-0.3-0.2-1.30.0
Bone: periosteal estimation0.20.41.3-0.5-0.31.00.50.7-0.8-0.60.6-0.7-0.80.20.80.70.91.1-0.90.5-0.50.1-0.3-0.20.0
Bone: periosteal perimeter0.10.21.2-0.00.50.7-0.0-0.0-0.00.0-0.00.2-0.01.0-0.0-0.10.00.90.0-0.0-1.1-0.50.30.80.0
Bone: post-yield work0.50.72.70.91.1-0.2-0.8-0.80.90.7-0.70.80.61.2-0.70.5-0.5-0.30.5-0.2-1.3-0.90.61.70.0
Progressive ratio test 1 active lever presses0.20.20.60.7-0.4-0.6-0.7-0.5-0.4-0.70.7-0.3-0.40.10.3-0.7-0.1-0.7-0.3-0.30.10.00.1-0.40.0
Progressive ratio test 1 breakpoint0.20.20.70.8-0.4-0.6-0.8-0.5-0.3-0.70.7-0.2-0.30.20.2-0.8-0.1-0.7-0.3-0.30.10.00.1-0.30.0
Progressive ratio test 1 inactive lever presses1.72.56.1-1.4-2.40.51.21.3-2.0-2.32.3-1.7-1.8-1.81.6-0.51.20.1-1.80.71.51.3-1.4-2.50.0
Progressive ratio test 2 active lever presses0.20.20.70.2-0.50.4-0.10.3-0.5-0.80.8-0.5-0.70.60.50.10.60.1-0.50.3-0.70.50.10.50.0
Progressive ratio test 2 breakpoint0.20.30.80.2-0.50.4-0.10.3-0.5-0.90.9-0.6-0.70.60.60.10.60.1-0.50.3-0.70.60.10.40.0
Progressive ratio test 2 inactive lever presses1.82.95.6-2.4-1.71.52.42.1-1.6-1.81.8-1.9-1.8-1.81.81.11.81.1-1.61.61.31.9-1.7-1.10.0
Incentive Sensitization - Responses0.20.30.80.10.40.2-0.1-0.10.80.3-0.30.60.50.8-0.60.2-0.2-0.20.6-0.3-0.9-0.10.90.90.0
Incentive Sensitization - Breakpoint0.10.20.70.00.30.30.10.10.60.1-0.10.40.30.7-0.40.3-0.0-0.00.4-0.1-0.90.10.70.80.0
Sum of active levers in priming session hrs 5-60.80.72.2-1.5-0.81.01.41.0-0.9-0.30.3-0.8-0.6-1.30.8-0.10.61.1-0.40.70.90.8-0.8-0.70.0
Progressive ratio0.20.41.40.1-0.61.0-0.10.3-0.8-0.90.9-0.5-0.71.20.5-0.60.50.8-0.6-0.2-0.80.20.20.20.0
Food seeking constrained by brief footshock0.50.63.0-0.7-0.60.90.81.0-0.2-0.60.6-0.5-0.7-0.10.61.71.10.7-1.20.8-0.20.6-0.90.10.0
Seeking ratio, punishment vs. effort0.30.42.0-0.20.7-0.50.3-0.11.10.9-0.90.70.7-0.8-0.61.4-0.3-0.30.40.20.2-0.4-0.10.10.0
Retroperitoneal fat weight7.230.644.86.76.7-6.5-6.5-6.46.66.6-6.66.26.43.7-6.1-1.9-5.7-5.75.9-5.0-2.2-5.34.93.60.0
Reaction time number correct0.30.61.31.00.8-0.6-1.0-0.80.80.8-0.80.90.91.0-0.9-0.7-0.8-0.60.6-1.1-0.9-0.70.80.30.0
Reaction time mean minus median0.92.36.71.90.9-2.1-2.1-2.11.10.9-0.91.41.40.7-1.5-2.6-2.1-1.61.8-1.7-0.1-1.21.70.60.0
Reaction time mean minus median AUC1.12.85.62.31.4-2.3-2.4-2.31.31.3-1.31.51.61.3-1.6-2.2-2.0-1.91.9-1.6-0.6-1.31.71.10.0
Reaction time num false alarms0.30.43.40.20.80.70.10.20.60.2-0.20.20.10.9-0.21.90.40.4-0.20.6-1.20.1-0.31.10.0
Reaction time num false alarms AUC0.20.32.9-0.30.40.90.40.40.2-0.10.1-0.0-0.20.50.11.70.60.7-0.50.6-0.90.0-0.40.50.0
Reaction time trials correct on left0.30.61.31.00.8-0.6-1.0-0.80.80.8-0.80.90.91.0-0.9-0.7-0.8-0.60.6-1.1-0.9-0.70.80.30.0
Reaction time trials on left0.40.71.31.10.8-0.6-1.1-0.90.80.8-0.80.90.91.1-0.9-0.7-0.8-0.60.6-1.1-0.9-0.70.80.30.0
Reaction time mean0.30.51.80.3-0.6-1.1-0.4-0.5-0.4-0.50.5-0.3-0.1-1.00.1-1.3-0.6-1.10.5-0.21.30.40.0-1.20.0
Reaction time mean AUC0.30.51.90.6-0.3-1.4-0.7-0.8-0.2-0.30.3-0.10.1-0.8-0.1-1.4-0.7-1.30.7-0.31.20.20.1-1.00.0
Median of all reaction times0.40.52.3-0.2-0.8-0.70.2-0.0-0.8-0.80.8-0.7-0.5-1.30.6-0.7-0.0-0.70.10.31.40.8-0.4-1.50.0
Reaction time omissions0.20.21.01.0-0.2-0.6-0.9-0.70.0-0.70.70.0-0.10.4-0.1-0.7-0.3-0.70.30.3-0.30.2-0.00.20.0
Reaction time false alarm rate0.20.32.8-0.40.30.70.60.50.0-0.20.2-0.2-0.30.10.31.70.60.6-0.41.0-0.40.3-0.60.50.0
Reaction time premature initiation rate0.20.31.6-0.20.4-0.50.2-0.40.60.8-0.80.40.6-0.7-0.50.6-0.6-1.10.3-0.41.30.0-0.2-0.60.0
Reaction time premature initiations0.20.41.10.20.7-0.6-0.2-0.70.91.1-1.10.70.9-0.1-0.80.1-0.9-1.00.5-0.90.5-0.30.2-0.30.0
Std. dev. reaction times0.40.72.71.40.2-1.6-1.4-1.30.20.1-0.10.30.50.2-0.5-1.5-1.1-1.40.9-0.60.3-0.40.7-0.00.0
Reaction time trials completed0.40.71.31.10.8-0.6-1.1-0.90.80.8-0.80.90.91.1-0.9-0.7-0.8-0.60.6-1.1-0.9-0.70.80.30.0
Reaction time trials AUC0.30.61.21.00.8-0.6-1.0-0.80.80.8-0.80.90.91.1-0.9-0.6-0.7-0.60.6-1.1-0.9-0.70.80.30.0
Run reversals in cocaine runway, females3.33.38.31.22.1-0.1-1.4-1.61.51.4-1.42.11.62.5-1.8-1.6-1.90.31.9-1.7-2.9-2.72.42.10.0
Run reversals in cocaine runway, males0.20.21.7-0.20.60.10.30.20.20.3-0.3-0.0-0.0-0.10.11.30.4-0.30.00.6-0.60.1-0.01.10.0
Latency to leave start box in cocaine runway0.50.51.6-0.20.8-0.90.2-0.40.91.3-1.30.50.9-1.2-0.60.6-0.7-0.50.7-0.21.3-0.10.1-0.50.0
Latency to leave start box in cocaine runway, F0.30.41.00.51.0-0.7-0.4-0.70.80.9-0.90.70.7-0.0-0.60.5-0.6-0.40.5-0.3-0.1-0.80.50.20.0
Latency to leave start box in cocaine runway, M0.90.96.1-1.3-0.4-0.21.20.60.10.4-0.4-0.40.2-2.20.10.40.0-0.10.10.22.51.1-0.7-1.50.0
Std. dev. time between licks in bursts1.21.64.72.21.4-1.6-1.9-1.41.21.5-1.51.01.11.3-1.0-0.0-0.7-1.70.9-0.5-0.6-0.80.71.90.0
Total sessions with >9 infusions0.60.82.1-0.8-1.10.40.70.7-1.4-1.31.3-1.2-1.2-0.81.2-0.40.80.5-0.80.50.60.8-0.5-0.60.0
Short access day 1 total inactive lever presses0.60.74.7-1.4-0.8-0.31.20.6-0.6-0.30.3-0.5-0.3-2.20.4-0.9-0.0-0.00.20.11.80.7-0.1-1.20.0
Short access day 10 total inactive lever presses1.23.05.90.51.4-2.3-0.9-1.62.01.7-1.72.12.1-0.6-2.2-2.1-2.4-1.92.3-2.30.7-1.61.6-0.70.0
Short access day 1 total infusions0.10.20.9-0.60.1-0.00.50.1-0.4-0.20.2-0.2-0.2-0.40.2-1.0-0.20.30.5-0.3-0.1-0.10.70.70.0
Short access day 10 total infusions0.50.62.2-0.7-0.91.00.60.4-1.5-1.01.0-1.1-0.9-0.00.9-1.30.31.1-0.50.2-0.30.60.0-0.20.0
Short access total infusions0.10.21.90.1-0.3-0.4-0.2-0.3-0.6-0.20.2-0.3-0.2-0.20.2-1.4-0.4-0.10.3-0.40.10.20.4-0.20.0
Short access day 1 locomotion0.70.92.5-1.2-0.90.21.10.9-1.6-0.90.9-1.4-1.2-1.31.4-0.40.80.6-0.80.31.00.5-0.6-1.20.0
Short access day 10 total locomotion0.91.64.4-1.8-1.11.51.71.4-1.7-1.11.1-1.5-1.5-0.81.60.21.32.1-1.11.10.20.7-1.2-0.30.0
Short access total locomotion1.11.43.5-1.2-1.20.41.10.8-1.9-1.11.1-1.6-1.4-1.51.6-0.40.90.9-1.00.71.40.9-1.2-1.40.0
One hour access (0.3 mA shock)0.50.61.40.90.4-0.9-0.9-0.81.10.0-0.01.00.80.6-1.1-1.2-1.0-0.70.9-0.9-0.4-0.31.00.50.0
Compulsive drug intake1.11.35.60.30.2-1.3-0.7-0.71.01.2-1.21.21.4-0.6-1.4-2.4-1.4-1.01.2-1.60.8-0.50.8-1.50.0
One hour access (shock baseline)0.50.72.70.3-0.00.50.10.3-0.5-1.11.1-0.8-1.00.70.91.61.00.2-0.81.2-0.80.6-0.41.60.0
Social response proportion1.11.36.20.81.9-0.1-0.6-0.81.31.1-1.11.00.91.7-0.90.8-0.70.21.20.1-1.7-0.80.82.50.0
Social responses0.20.32.10.50.70.1-0.4-0.30.50.4-0.40.40.31.0-0.20.5-0.0-0.10.30.3-0.8-0.30.01.40.0
Social time1.01.46.51.01.7-0.3-0.8-1.01.31.2-1.21.11.11.7-1.10.2-0.9-0.21.4-0.1-1.6-0.71.02.50.0
Soleus weight1.75.010.4-2.7-3.21.52.52.3-2.6-2.52.5-2.4-2.3-2.82.3-0.01.91.0-2.21.52.62.1-2.1-2.50.0
Bone: stiffness1.32.13.7-1.6-1.21.71.71.5-1.8-1.31.3-1.7-1.8-0.81.91.61.71.9-1.71.70.30.8-1.10.30.0
Tibialis anterior weight0.00.11.00.2-0.1-0.5-0.4-0.3-0.00.1-0.10.20.2-0.2-0.2-1.0-0.4-0.50.2-0.70.2-0.50.4-0.40.0
Time to tail flick, vehicle, before self-admin0.91.03.8-0.7-1.2-0.20.70.7-0.7-0.80.8-0.9-0.8-1.90.80.50.7-1.1-1.00.31.91.1-1.1-1.50.0
Time to tail flick, vehicle, after self-admin0.30.41.2-0.2-1.10.20.20.5-0.9-1.01.0-0.7-0.8-0.20.7-0.30.60.3-0.60.40.40.5-0.5-0.90.0
Time to tail flick, test, before self-admin3.03.17.6-2.3-1.31.92.62.3-1.0-1.01.0-1.7-1.5-1.71.72.82.11.9-1.72.21.01.9-1.7-0.10.0
Time to tail flick, test, after self-admin0.30.31.4-0.50.00.40.70.4-0.5-0.10.1-0.7-0.5-0.30.71.20.60.2-0.20.90.10.5-0.20.70.0
Delta time to tail flick, vehicle, before/after SA0.20.20.90.6-0.1-0.2-0.6-0.3-0.3-0.30.30.0-0.00.9-0.1-0.9-0.20.60.2-0.2-0.7-0.30.2-0.40.0
Delta time to tail flick, test, before/after SA3.94.07.72.72.0-2.3-2.8-2.71.61.6-1.62.02.01.9-2.0-2.0-2.4-2.32.1-2.1-1.2-2.01.90.70.0
Tibia length0.30.82.20.91.5-0.6-0.8-0.60.91.4-1.40.70.70.9-0.41.5-0.1-0.00.0-0.7-0.8-1.10.60.90.0
Ambulatory time before self-admin0.20.21.6-0.8-0.40.90.70.4-0.7-0.20.2-0.4-0.30.00.4-0.50.11.3-0.40.2-0.30.0-0.3-0.30.0
Ambulatory time after self-admin1.51.84.1-2.0-1.11.52.01.5-1.4-0.90.9-1.5-1.3-1.51.40.91.21.7-1.21.40.91.4-1.4-0.20.0
Bone: tissue strength0.80.82.10.91.5-0.6-0.8-0.91.20.9-0.91.11.01.0-1.00.4-0.8-0.11.1-0.4-1.3-0.81.00.60.0
Total heroin consumption0.81.03.1-0.8-1.51.30.50.8-1.2-1.61.6-0.6-0.90.10.6-1.80.51.4-0.70.0-0.30.6-0.5-1.30.0
Bone: trabecular number1.32.15.1-1.6-2.00.81.51.5-1.4-1.51.5-1.5-1.3-2.01.30.11.20.5-1.31.01.81.8-1.6-2.30.0
Bone: trabecular spacing3.14.18.22.32.7-1.2-2.3-2.21.92.1-2.12.22.02.9-2.0-0.6-1.9-0.91.8-1.8-2.5-2.52.12.20.0
Bone: trabecular thickness5.97.311.6-2.8-3.12.23.02.9-2.8-2.82.8-3.3-3.0-2.83.12.12.91.5-2.92.82.43.4-2.8-1.90.0
Bone: trabecular tissue density1.21.73.9-1.2-1.81.71.11.3-1.6-2.02.0-1.4-1.6-0.31.3-0.21.21.3-1.31.50.11.5-1.1-0.20.0
Water consumed over 24 hours0.60.91.5-1.2-1.01.11.11.0-1.2-1.01.0-1.1-1.1-0.81.1-0.10.91.0-1.20.20.40.9-0.8-1.00.0
Number of responses in last shaping day1.21.33.1-1.3-1.51.01.31.1-1.4-1.81.8-1.4-1.4-0.81.2-0.20.90.7-1.10.60.61.1-0.7-0.80.0