Hub : Genes

Dazap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Dazap1 0.03 0.02 3.7e-03 0.02 0.01 0.01 0.01 8.5e-04 1.3e-02 1.8e-02 6.2e-03
2 Liver mRNA stability Dazap1 0.15 0.09 1.1e-15 0.14 0.12 0.13 0.13 7.4e-15 1.4e-13 6.6e-14 5.4e-14
3 Brain mRNA stability Dazap1 0.06 0.05 5.3e-04 0.03 0.03 0.02 0.03 1.1e-03 8.9e-04 5.2e-03 1.0e-03
4 Adipose mRNA stability Dazap1 0.05 0.03 1.5e-04 0.03 0.03 0.03 0.03 1.2e-04 1.7e-04 1.0e-04 1.3e-04
5 Liver alternative polyA XM_006240970.4 0.07 0.05 9.0e-05 0.01 0.02 0.03 0.02 1.9e-02 3.2e-03 6.0e-04 1.6e-03
6 Liver isoform ratio NM_001025742.1 0.05 0.04 7.2e-04 0.02 0.03 0.03 0.03 5.0e-03 4.4e-04 2.3e-04 1.7e-04
7 Liver isoform ratio XM_006240968.4 0.06 0.05 8.9e-05 0.02 0.02 0.03 0.03 4.6e-03 9.0e-04 1.9e-04 4.2e-04
8 Liver alternative polyA XM_006240970.4 0.04 0.03 6.2e-03 0.01 0.01 0.02 0.01 5.0e-02 2.1e-02 4.3e-03 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.52.55.31.00.9-1.91.12.32.11.41.3
Area under the delay curve1.01.12.4-1.3-1.51.0-1.3-0.7-0.50.51.0
BMI with tail4.815.723.4-4.8-4.83.8-4.8-3.9-3.6-2.8-2.3
BMI without tail2.95.98.9-3.0-2.82.8-2.7-2.7-2.5-1.0-0.7
Body weight0.93.65.9-2.4-2.32.0-2.3-1.9-1.7-1.0-0.8
Weight adjusted by age1.11.22.6-1.2-1.01.6-1.0-1.3-1.3-0.3-0.3
Bone surface4.27.413.72.01.9-3.22.13.73.42.62.4
Bone volume4.57.713.91.91.9-3.02.13.73.42.82.7
Breakpoint value in progressive ratio session1.82.04.32.01.9-1.12.11.11.00.60.3
Number of licking bursts0.70.81.6-0.5-0.81.2-0.6-1.1-1.2-0.8-0.7
Context. condit. distance diff. score0.30.30.6-0.8-0.70.6-0.6-0.5-0.50.20.3
Locomotion velocity, session 11.51.62.61.31.4-1.61.21.51.50.80.7
Locomotion distance, session 11.62.15.61.41.2-2.40.91.61.6-0.7-1.0
Locomotion velocity, session 25.46.311.23.02.9-3.42.62.82.70.70.4
Locomotion distance, session 23.54.910.12.62.4-3.22.12.52.4-0.3-0.7
Locomotion velocity, session 33.44.06.32.52.5-1.62.51.71.61.61.6
Locomotion distance, session 30.10.10.3-0.3-0.10.4-0.1-0.2-0.20.50.5
Stereotopy head waving bouts, day 33.84.47.52.72.4-2.52.52.12.10.80.6
Stereotopy head waving duration, day 34.04.78.12.82.6-2.32.72.12.01.10.9
Locomotion velocity, session 72.32.57.80.41.1-0.21.01.01.02.72.8
Locomotion distance, session 70.60.71.7-1.0-0.51.3-0.6-0.9-0.90.60.7
Stereotopy head waving bouts, day 70.70.81.30.60.5-1.20.51.11.10.90.9
Stereotopy head waving duration, day 71.31.62.41.00.9-1.51.01.61.51.11.0
Locomotion velocity, session 82.22.64.81.61.5-2.21.42.02.00.90.7
Locomotion distance, session 80.40.51.40.80.6-1.20.60.70.7-0.4-0.6
Degree of sensitization distance0.20.20.4-0.6-0.50.4-0.6-0.4-0.3-0.1-0.1
Degree of sensitization stereotypy0.40.41.0-1.0-0.90.2-0.9-0.00.00.40.5
Conditioned locomotion2.63.14.5-1.8-1.82.1-1.8-2.1-2.0-1.1-0.9
Cocaine response after cond. corrected6.37.111.2-3.2-3.03.3-3.0-3.0-2.8-0.7-0.2
Cocaine response after cond. not corrected6.97.612.0-3.4-3.03.5-3.1-3.1-2.9-0.8-0.3
Cocaine response before conditioning0.70.81.10.81.1-0.80.90.90.91.00.9
Saline control response0.20.30.7-0.3-0.50.4-0.4-0.5-0.5-0.8-0.8
Bone: connectivity density0.60.92.10.40.3-1.30.41.51.30.91.0
Bone: cortical apparent density0.50.61.1-0.9-1.00.8-1.0-0.7-0.7-0.6-0.5
Bone: cortical area0.40.62.1-0.4-0.2-0.2-0.10.80.71.31.4
Bone: cortical porosity1.01.11.51.11.1-1.21.11.21.20.70.5
Bone: cortical porosity0.80.91.70.80.8-1.20.71.31.20.60.4
Bone: cortical thickness0.20.41.0-1.0-0.90.4-0.9-0.2-0.20.00.1
Bone: cortical thickness0.40.41.3-0.6-0.41.1-0.4-0.8-0.70.40.5
Bone: cortical tissue density0.40.50.8-0.8-0.90.7-0.8-0.6-0.6-0.5-0.4
Condit. Reinf. active minus inactive responses2.42.74.82.22.1-1.72.11.51.40.90.8
Condit. Reinf. active-inactive response ratio0.60.71.41.11.2-0.41.20.40.40.70.7
Condit. Reinf. active responses3.44.17.02.72.3-2.52.32.12.00.50.2
Condit. Reinf. inactive responses1.92.24.91.81.4-2.21.41.71.6-0.2-0.5
Incentive salience index mean2.22.64.22.01.8-2.01.81.71.70.60.4
Condit. Reinf. lever presses1.11.44.11.10.7-2.00.81.61.5-0.2-0.4
Condit. Reinf. active minus inactive responses0.50.71.51.11.1-0.01.20.40.30.80.7
Condit. Reinf. active-inactive response ratio0.90.91.6-0.2-0.51.1-0.4-1.2-1.1-1.2-1.2
Condit. Reinf. active responses1.52.03.71.31.5-0.51.61.11.01.91.9
Condit. Reinf. inactive responses2.32.86.90.91.5-0.61.41.41.32.62.6
Condit. Reinf. lever presses0.70.91.91.21.4-0.31.40.50.50.80.8
Condit. Reinf. lever reinforcers received1.01.43.20.91.20.01.30.70.61.81.8
Conditioned reinforcement - actives1.31.32.31.41.5-1.01.51.11.00.70.5
Conditioned reinforcement - inactives0.80.91.2-1.1-0.91.0-1.0-1.1-1.0-0.6-0.4
Conditioned locomotion3.84.68.32.82.9-2.02.81.91.81.20.9
Patch foraging indifference point 0 sec0.00.00.1-0.3-0.40.0-0.20.10.10.10.1
Patch foraging indifference point AUC0.40.40.80.80.9-0.40.80.20.2-0.5-0.8
Delay disc. indifference point, 0s delay1.21.33.8-1.6-1.90.1-1.9-0.4-0.2-0.7-0.5
Delay disc. indifference point, 16s delay0.10.10.3-0.2-0.50.2-0.2-0.1-0.10.20.5
Delay disc. indifference point, 2s delay1.92.14.8-2.2-2.21.1-2.1-0.9-0.80.10.3
Delay disc. indifference point, 24s delay0.70.61.2-1.1-1.01.0-0.8-0.8-0.70.10.2
Delay disc. indifference point, 4s delay0.80.83.1-0.6-1.00.2-0.60.10.21.31.8
Delay disc. indifference point, 8s delay1.11.12.0-1.2-1.31.4-1.2-1.1-1.0-0.30.2
Indifference point function ln k0.50.72.1-0.8-0.70.7-0.5-0.2-0.21.21.4
Indifference point function log k0.50.72.1-0.8-0.70.7-0.5-0.2-0.21.21.4
Patch foraging total patch changes 0 sec0.00.00.2-0.3-0.40.1-0.2-0.0-0.00.00.0
Patch foraging total patch changes 12 sec1.52.04.0-0.9-1.01.1-1.1-1.5-1.4-1.9-2.0
Patch foraging total patch changes 18 sec0.50.71.41.21.1-0.81.10.70.6-0.1-0.3
Patch foraging total patch changes 24 sec0.20.20.80.40.2-0.30.30.10.1-0.7-0.9
Patch foraging total patch changes 6 sec0.20.30.60.80.6-0.60.70.50.5-0.2-0.4
Patch foraging time to switch 0 sec0.50.72.1-0.3-0.6-0.9-0.70.20.2-1.4-1.5
Patch foraging water rate 0 sec0.81.33.7-1.1-0.81.9-0.6-1.2-1.20.81.0
Patch foraging water rate 12 sec2.43.77.1-2.2-2.02.7-1.9-2.3-2.2-0.5-0.2
Patch foraging water rate 18 sec1.92.66.8-1.2-1.22.6-1.0-2.3-2.2-0.4-0.2
Patch foraging water rate 24 sec3.24.49.0-1.9-1.83.0-1.8-2.8-2.6-0.9-0.7
Patch foraging water rate 6 sec0.40.62.3-0.5-0.31.5-0.2-1.1-1.00.40.5
Seeking ratio, delayed vs. immediate footshock3.74.36.22.42.3-2.02.52.22.11.51.3
Distance traveled before self-admin0.10.10.2-0.4-0.50.0-0.4-0.10.0-0.3-0.3
Distance traveled after self-admin0.50.60.90.80.9-0.80.90.80.80.40.2
Extensor digitorum longus weight4.015.924.2-4.9-4.84.2-4.8-4.1-4.0-2.1-1.6
Bone: elastic displacement0.30.30.40.60.7-0.40.70.60.60.50.4
Bone: elastic work0.40.62.1-0.4-0.10.2-0.10.50.41.41.4
Bone: endosteal estimation0.10.20.8-0.4-0.40.2-0.30.30.20.80.9
Bone: endosteal perimeter1.02.03.60.91.1-1.11.21.51.41.91.9
Epididymis fat weight0.20.61.90.60.2-0.20.1-0.5-0.4-1.3-1.4
Delta time in closed arm before/after self-admin4.03.86.1-1.9-1.82.5-1.7-2.4-2.4-1.4-1.3
Delta time in open arm before/after self-admin0.30.30.7-0.6-0.60.3-0.8-0.4-0.3-0.4-0.3
Diff in mean of infusions in LGA sessions0.91.01.91.31.3-1.11.41.00.90.50.4
Delay discount exponential model param1.01.12.31.31.5-1.11.20.70.6-0.5-1.0
Extinction: sum of active levers before priming0.30.31.00.60.40.00.5-0.3-0.4-0.8-1.0
Active lever presses in extinction session 61.81.73.01.41.6-1.31.71.41.30.70.5
Bone: final force0.30.51.1-1.0-0.70.5-0.80.20.10.91.1
Bone: final moment0.30.51.1-0.9-0.60.4-0.60.20.20.91.1
Food consumed during 24 hour testing period0.50.61.2-0.9-1.11.0-0.8-0.5-0.60.30.5
Glucose1.01.52.5-1.6-1.61.3-1.5-1.1-1.1-0.5-0.4
Heart weight0.10.10.20.20.20.30.2-0.4-0.4-0.2-0.3
Delay discount hyperbolic model param1.31.43.01.51.7-1.21.50.80.6-0.5-0.9
Intermittent access intake day 1-15 change3.13.15.72.22.3-1.42.41.61.41.10.9
Intermittent access intake escalation1.51.43.61.71.8-0.61.90.80.60.50.3
Intermittent access intake escalation 21.91.95.12.02.3-0.72.10.80.60.50.3
Intermitt. access day 1 inactive lever presses0.10.10.4-0.3-0.10.7-0.0-0.4-0.50.30.4
Intermitt. access day 15 inactive lever presses0.10.10.40.50.6-0.20.50.10.10.20.2
Intermitt. access escalation Index0.40.41.10.10.1-0.60.31.00.80.60.5
Intermittent access day 1 total infusions0.00.00.1-0.2-0.10.0-0.20.00.00.40.4
Intermittent access day 15 total infusions0.50.61.41.01.2-0.41.10.50.40.60.5
Intermittent access terminal intake (last 3 days)0.50.51.10.81.0-0.51.00.60.50.60.5
Intermittent access total infusions0.00.00.10.20.3-0.00.30.10.10.20.2
Intermittent access day 1 locomotion0.10.10.30.50.6-0.30.50.20.20.30.3
Intermittent access day 15 total locomotion1.51.63.41.81.8-1.21.71.00.90.1-0.1
Intermittent access total locomotion0.50.61.11.01.1-0.81.00.80.70.20.1
Intermittent access standard deviation0.80.82.41.21.5-0.41.30.50.50.60.5
Left kidney weight0.20.40.70.60.8-0.70.60.80.90.50.3
Right kidney weight1.02.95.02.02.2-1.52.11.61.61.31.0
Cocaine induced anxiety1.21.42.61.31.4-1.61.21.31.40.1-0.2
Post-drug Anxiety1.21.32.61.31.4-1.61.01.11.30.40.4
Baseline Anxiety0.10.10.4-0.00.10.5-0.1-0.6-0.50.20.4
Tail length1.33.97.42.52.7-1.52.71.61.51.41.2
Length with tail1.65.88.62.72.9-2.22.92.42.32.01.7
Length without tail0.61.32.20.91.0-1.30.91.51.41.00.9
Times rat made contact with spout0.60.71.3-0.8-0.91.2-0.8-0.9-1.0-0.3-0.1
Lifetime Intake0.00.00.00.10.2-0.10.20.10.10.20.2
Liver weight, left2.84.55.5-2.0-2.31.6-2.3-2.1-2.0-2.3-2.1
Liver weight, right1.42.33.7-1.4-1.60.8-1.7-1.3-1.2-1.9-1.8
Locomotor activity4.16.58.42.82.8-2.62.92.92.71.71.4
Locomotor testing distance2.13.44.82.12.1-1.92.22.11.91.21.0
Locomotor testing rearing0.10.10.4-0.3-0.10.6-0.1-0.4-0.40.30.4
Locomotion in novel chamber0.50.62.60.30.10.30.2-0.4-0.5-1.4-1.6
Locomotion in novel chamber post-restriction0.70.82.10.80.6-0.20.90.60.61.41.4
Fecal boli incidents, locomotor time 13.33.67.6-1.5-1.21.3-1.7-1.8-1.7-2.8-2.7
Change in fecal boli incidents, locomotor task3.43.210.30.10.4-0.50.91.41.43.23.2
Time >=10cm from walls, locomotor time 10.10.10.2-0.30.1-0.4-0.10.40.5-0.0-0.2
Bouts of movement, locomotor time 10.10.10.20.10.40.00.30.10.10.40.4
Total resting periods, locomotor time 10.20.20.50.30.6-0.20.50.40.40.70.7
Rest time, locomotor task time 10.20.30.50.60.5-0.70.50.50.50.20.2
Distance moved, locomotor task time 10.30.41.0-0.4-0.3-0.3-0.10.60.61.00.9
Vertical activity count, locomotor time 10.70.71.8-0.8-0.61.1-0.3-0.3-0.31.11.3
Time >=10cm from walls, locomotor time 21.21.32.1-1.5-1.11.5-1.3-1.1-1.1-0.7-0.6
Bouts of movement, locomotor time 21.31.42.51.41.3-1.61.01.31.30.40.3
Total resting periods, locomotor time 21.31.42.51.41.3-1.61.01.41.30.50.4
Rest time, locomotor task time 20.91.01.41.11.2-1.21.11.11.10.70.5
Distance moved, locomotor task time 21.11.21.6-1.1-1.31.1-1.2-1.1-1.1-1.0-1.0
Vertical activity count, locomotor time 21.71.92.7-1.4-1.41.6-1.3-1.6-1.5-1.1-0.9
Light reinforcement 14.27.613.53.73.6-3.13.42.72.50.50.0
Light reinforcement 21.82.44.01.92.0-1.71.81.61.50.70.5
Bone: marrow area0.10.20.7-0.4-0.40.2-0.30.30.20.70.8
Bone: maximum diameter1.83.34.51.51.7-1.81.72.12.01.91.8
Bone: maximum force0.50.81.5-1.2-0.90.8-0.9-0.1-0.11.01.2
Bone: maximum moment0.40.71.5-1.1-0.70.7-0.80.0-0.01.01.2
Mean time between licks in bursts1.62.24.92.22.1-1.22.11.11.00.30.1
Mean num. licks in bursts0.10.20.5-0.20.1-0.20.00.30.30.70.7
Cd content in liver0.00.00.1-0.3-0.20.2-0.3-0.0-0.1-0.1-0.0
Co content in liver0.20.20.50.70.7-0.30.60.20.2-0.1-0.2
Cu content in liver0.30.40.80.20.5-0.80.20.90.80.50.5
Fe content in liver0.10.10.2-0.10.00.3-0.1-0.5-0.4-0.5-0.5
K content in liver0.50.51.30.60.5-1.10.40.90.9-0.1-0.2
Mg content in liver0.50.51.30.60.5-1.10.51.11.00.30.2
Mn content in liver4.65.28.01.92.1-2.51.92.82.72.22.0
Na content in liver0.20.30.6-0.3-0.4-0.5-0.50.20.2-0.7-0.8
Rb content in liver0.20.30.60.00.1-0.8-0.00.80.80.40.4
Se content in liver0.20.20.40.60.6-0.60.50.50.4-0.0-0.1
Sr content in liver0.40.40.8-0.4-0.40.9-0.4-0.8-0.9-0.5-0.5
Zn content in liver0.30.40.60.50.40.60.5-0.8-0.8-0.6-0.7
Bone: minimum diameter0.40.72.00.20.2-0.40.40.90.81.41.4
Time in familiar zone, hab. session 11.11.01.81.11.1-0.41.20.60.61.21.3
Time in novel zone, hab. session 10.20.20.4-0.6-0.4-0.1-0.40.30.40.50.5
Total zone transitions, hab. session 12.02.75.41.91.8-2.31.61.91.90.1-0.2
Total locomotion distance, hab. session 13.44.88.42.22.2-2.92.02.72.61.10.9
Locomotion velocity, hab. session 13.24.58.72.42.3-2.92.12.42.40.3-0.0
Time in familiar zone, hab. session 21.91.94.01.91.9-0.82.00.80.81.01.0
Time in novel zone, hab. session 21.01.02.8-1.7-1.50.7-1.6-0.4-0.4-0.10.1
Total zone transitions, hab. session 21.31.74.31.00.7-2.10.31.21.2-1.4-1.7
Total locomotion distance, hab. session 22.22.96.32.01.8-2.51.51.71.7-0.6-1.0
Locomotion velocity, hab. session 22.73.68.32.21.9-2.91.62.01.9-0.8-1.2
Novel to familiar place preference ratio0.70.82.3-1.5-1.40.3-1.4-0.2-0.1-0.1-0.0
Novelty place preference0.40.41.2-1.1-0.90.0-1.00.10.10.10.1
Time in novel zone, NPP test0.50.51.6-1.3-1.10.2-1.1-0.1-0.00.10.1
Total zone transitions, NPP test1.31.85.31.00.6-1.70.30.70.7-2.0-2.3
Total locomotion distance, NPP test0.71.02.60.80.7-1.60.41.01.0-0.9-1.1
Locomotion velocity, NPP test0.91.33.31.10.9-1.80.61.11.1-0.9-1.2
Intraocular pressure1.01.42.5-0.7-0.71.6-0.7-1.6-1.6-1.1-1.0
Delta distance traveled before/after self-admin1.11.22.21.21.5-1.01.41.01.00.80.6
Delta ambulatory time before/after self-admin1.41.52.51.31.6-1.21.51.21.20.80.7
Parametrial fat weight0.10.20.50.40.6-0.10.70.30.30.60.5
Pavlov. Cond. lever latency0.40.51.5-0.5-0.41.2-0.4-1.0-1.0-0.3-0.2
Pavlov. Cond. magazine entry latency1.21.63.61.91.6-1.41.71.00.90.1-0.0
Pavlov. Cond. change in total contacts0.10.10.30.40.2-0.50.30.20.2-0.3-0.3
Pavlov. Cond. index score0.70.91.91.10.9-1.40.91.01.00.30.2
Pavlov. Cond. latency score1.01.32.81.21.0-1.71.11.31.30.50.4
Pavlov. Cond. lever contacts0.81.02.40.80.6-1.50.71.31.30.50.3
Pavlov. Cond. magazine entry number0.40.51.1-1.0-0.80.9-0.8-0.6-0.5-0.00.1
Pavlov. Cond. intertrial magazine entries0.20.20.5-0.0-0.10.7-0.1-0.7-0.7-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.91.22.11.31.1-1.51.21.21.10.50.4
Pavlov. Cond. response bias0.70.81.71.31.1-1.11.10.80.80.1-0.0
Pavlov. Cond. lever latency1.21.74.0-0.7-1.30.3-1.1-0.9-0.9-2.0-2.0
Pavlov. Cond. magazine entry latency0.80.92.10.50.9-0.40.80.70.71.41.4
Pavlov. Cond. change in total contacts0.71.02.40.71.1-0.11.00.70.71.51.5
Pavlov. Cond. index score1.11.43.50.61.2-0.21.10.80.81.91.9
Pavlov. Cond. latency score1.31.63.70.71.3-0.41.11.01.01.91.9
Pavlov. Cond. lever contacts0.81.02.90.51.00.10.90.50.51.71.7
Pavlov. Cond. magazine entry number1.21.53.3-0.7-1.10.5-1.1-1.0-1.0-1.8-1.8
Pavlov. Cond. intertrial magazine entries0.60.81.3-1.0-1.01.2-0.9-1.1-1.0-0.4-0.3
Pavlov. Cond. lever-magazine prob. diff.1.21.63.60.71.3-0.41.21.01.01.91.9
Pavlov. Cond. response bias1.31.83.81.01.5-0.21.40.80.81.91.9
Time in closed arm before self-admin0.20.20.60.0-0.1-0.8-0.30.60.6-0.4-0.5
Time in closed arm after self-admin0.00.00.1-0.0-0.10.10.0-0.2-0.2-0.3-0.3
Time in open arm before self-admin0.30.30.60.40.5-0.20.80.40.30.80.7
Time in open arm after self-admin0.40.50.9-0.8-0.90.8-0.9-0.7-0.6-0.2-0.0
Bone: periosteal estimation0.40.72.3-0.3-0.1-0.3-0.00.90.81.41.5
Bone: periosteal perimeter1.11.93.60.70.9-1.00.91.61.51.91.9
Bone: post-yield work0.40.61.0-1.0-0.80.9-0.9-0.7-0.70.10.2
Progressive ratio test 1 active lever presses0.20.20.4-0.5-0.50.7-0.5-0.6-0.6-0.2-0.1
Progressive ratio test 1 breakpoint0.30.30.5-0.6-0.60.7-0.6-0.6-0.6-0.2-0.1
Progressive ratio test 1 inactive lever presses0.00.00.00.20.1-0.20.10.10.10.00.1
Progressive ratio test 2 active lever presses0.10.10.2-0.10.00.40.0-0.3-0.30.00.1
Progressive ratio test 2 breakpoint0.00.10.10.20.30.00.30.10.10.30.3
Progressive ratio test 2 inactive lever presses0.00.10.10.20.3-0.40.20.20.2-0.1-0.1
Incentive Sensitization - Responses0.10.10.2-0.2-0.10.5-0.0-0.4-0.4-0.3-0.3
Incentive Sensitization - Breakpoint0.00.00.1-0.10.00.40.1-0.2-0.3-0.1-0.1
Sum of active levers in priming session hrs 5-60.10.10.50.0-0.0-0.1-0.00.1-0.0-0.6-0.7
Progressive ratio1.51.84.9-0.4-0.70.5-0.9-1.1-1.1-2.2-2.2
Food seeking constrained by brief footshock0.81.03.20.80.5-1.00.30.00.1-1.7-1.8
Seeking ratio, punishment vs. effort0.50.60.90.80.8-0.90.70.80.80.50.4
Retroperitoneal fat weight0.31.11.4-1.0-1.20.9-1.2-1.1-1.1-1.1-0.9
Reaction time number correct1.52.24.5-1.7-1.62.1-1.4-1.7-1.60.20.5
Reaction time mean minus median0.60.82.00.71.0-0.10.80.50.51.31.4
Reaction time mean minus median AUC0.91.23.10.40.6-0.70.51.11.11.61.7
Reaction time num false alarms1.01.43.7-1.1-0.71.4-0.5-0.6-0.61.61.9
Reaction time num false alarms AUC1.01.42.8-1.3-1.01.7-0.7-1.0-1.01.21.5
Reaction time trials correct on left1.52.24.5-1.7-1.62.1-1.4-1.7-1.60.20.5
Reaction time trials on left1.42.04.2-1.6-1.62.0-1.3-1.6-1.50.20.5
Reaction time mean0.40.51.50.10.5-0.20.30.60.71.21.2
Reaction time mean AUC0.40.51.60.00.4-0.20.20.60.71.21.3
Median of all reaction times0.10.20.6-0.3-0.0-0.1-0.20.40.40.70.8
Reaction time omissions0.30.40.70.80.8-0.70.70.70.70.10.0
Reaction time false alarm rate0.30.41.4-0.4-0.20.3-0.00.10.11.11.2
Reaction time premature initiation rate0.20.30.70.80.8-0.10.80.10.10.0-0.1
Reaction time premature initiations0.20.31.00.00.11.00.2-0.8-0.70.20.3
Std. dev. reaction times0.50.72.00.40.8-0.10.60.60.61.31.4
Reaction time trials completed1.42.04.2-1.6-1.62.0-1.3-1.6-1.50.20.5
Reaction time trials AUC1.62.45.0-1.7-1.62.2-1.4-1.8-1.70.10.4
Run reversals in cocaine runway, females0.60.61.00.70.7-0.70.70.80.80.91.0
Run reversals in cocaine runway, males1.41.32.21.51.1-1.31.31.11.10.70.7
Latency to leave start box in cocaine runway2.22.43.81.51.4-1.61.51.91.81.31.1
Latency to leave start box in cocaine runway, F1.21.32.60.70.7-1.40.71.61.61.00.8
Latency to leave start box in cocaine runway, M0.40.41.21.01.0-0.11.10.30.10.20.0
Std. dev. time between licks in bursts2.32.75.71.01.3-1.01.41.61.62.42.4
Total sessions with >9 infusions0.20.20.4-0.00.1-0.30.20.50.50.70.7
Short access day 1 total inactive lever presses0.20.20.60.30.3-0.40.20.10.0-0.7-0.8
Short access day 10 total inactive lever presses0.10.10.3-0.2-0.00.3-0.2-0.5-0.5-0.5-0.6
Short access day 1 total infusions0.50.61.10.80.8-1.10.70.80.90.30.2
Short access day 10 total infusions0.10.10.2-0.2-0.10.3-0.1-0.2-0.20.30.5
Short access total infusions0.00.00.00.00.1-0.20.10.10.10.10.1
Short access day 1 locomotion1.61.72.01.21.4-1.21.31.41.41.21.2
Short access day 10 total locomotion1.61.73.51.71.8-0.91.91.11.01.00.8
Short access total locomotion0.80.81.20.91.1-0.71.10.90.90.90.9
One hour access (0.3 mA shock)0.10.20.3-0.5-0.40.4-0.5-0.3-0.30.30.5
Compulsive drug intake0.30.30.7-0.8-0.80.2-0.8-0.2-0.2-0.1-0.0
One hour access (shock baseline)0.10.10.3-0.20.00.5-0.0-0.3-0.30.40.6
Social response proportion1.11.22.11.41.3-1.41.01.00.9-0.6-0.8
Social responses6.28.012.43.33.5-2.73.32.92.71.91.6
Social time1.21.64.9-0.5-0.90.2-0.9-0.8-0.8-2.1-2.2
Soleus weight5.114.827.4-5.2-5.13.9-5.0-3.4-3.3-1.3-0.7
Bone: stiffness1.01.63.7-1.9-1.71.2-1.7-0.7-0.80.30.5
Tibialis anterior weight0.72.44.6-2.1-2.11.5-2.0-1.4-1.3-0.4-0.1
Time to tail flick, vehicle, before self-admin1.31.32.01.21.1-1.41.01.31.30.70.7
Time to tail flick, vehicle, after self-admin0.30.40.8-0.0-0.20.8-0.2-0.9-0.9-0.6-0.5
Time to tail flick, test, before self-admin1.11.02.01.00.9-1.20.91.41.20.70.5
Time to tail flick, test, after self-admin0.50.61.01.00.7-0.90.70.90.80.40.5
Delta time to tail flick, vehicle, before/after SA2.01.93.1-1.1-1.31.7-1.2-1.8-1.7-1.0-0.9
Delta time to tail flick, test, before/after SA0.10.10.3-0.00.00.4-0.1-0.6-0.5-0.2-0.1
Tibia length0.41.22.31.41.5-0.91.50.90.90.70.6
Ambulatory time before self-admin0.10.10.3-0.5-0.50.1-0.4-0.1-0.1-0.2-0.2
Ambulatory time after self-admin0.30.30.50.60.7-0.70.70.60.60.1-0.0
Bone: tissue strength0.80.71.2-1.0-1.00.6-1.1-0.6-0.6-1.0-0.9
Total heroin consumption1.21.42.31.51.3-1.21.51.31.10.70.6
Bone: trabecular number2.03.24.51.61.7-2.01.62.12.01.61.5
Bone: trabecular spacing3.34.37.3-1.8-1.82.7-1.7-2.7-2.5-1.5-1.3
Bone: trabecular thickness4.25.010.11.51.4-2.71.63.22.92.11.9
Bone: trabecular tissue density2.53.55.1-1.5-1.91.5-1.8-1.8-1.8-2.3-2.2
Water consumed over 24 hours0.30.41.2-0.5-0.40.0-0.30.40.41.01.1
Number of responses in last shaping day0.20.20.50.20.2-0.20.40.40.40.60.7