Hub : Genes

Cyp2r1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Cyp2r1 0.49 0.12 0.0e+00 0.03 0.13 0.14 0.12 6.3e-04 1.8e-14 7.1e-15 2.6e-13
2 Adipose alternative polyA NM_001401627.1 0.18 0.09 6.8e-05 0 0.01 0.02 0 8.4e-02 1.8e-02 2.4e-03 1.1e-01
3 Adipose alternative polyA NM_001401627.1 0.15 0.09 8.7e-04 0 0 0.01 0 1.4e-01 8.3e-02 6.1e-02 3.6e-01
4 Liver alternative polyA NM_001401627.1 0.13 0.08 3.3e-03 0 0.01 0.01 0 1.5e-01 1.1e-02 1.6e-02 1.2e-01
5 Liver alternative polyA NM_001401627.1 0.14 0.08 2.1e-04 0 0.02 0.02 0.01 2.2e-01 1.3e-03 9.1e-04 2.4e-02
6 Liver gene expression Cyp2r1 0.6 0.12 0.0e+00 0.07 0.22 0.21 0.22 6.4e-08 1.3e-23 4.9e-23 1.2e-23
7 Adipose isoform ratio XM_006230082.4 0.21 0.1 7.9e-06 0.02 0.03 0.02 0.02 8.7e-04 2.1e-04 9.7e-04 3.4e-03
8 Liver isoform ratio NM_001401627.1 0.04 0.03 4.2e-03 0.01 0.01 0.01 0.01 7.8e-03 2.6e-02 2.5e-02 1.5e-02
9 Adipose alternative polyA XM_006230082.4 0.23 0.1 2.2e-06 0.03 0.04 0.03 0.03 2.3e-04 2.7e-05 6.9e-04 9.8e-05
10 Adipose alternative polyA XM_006230082.4 0.15 0.08 4.7e-04 0.01 0.02 0.01 0.01 6.7e-03 3.6e-03 3.0e-02 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.40.71.51.0-1.2-1.2-0.81.0-0.5-1.00.5-0.5-0.5
Area under the delay curve0.20.20.50.7-0.7-0.6-0.10.10.5-0.20.1-0.5-0.5
BMI with tail1.34.39.90.1-3.1-3.1-3.02.2-2.6-1.70.7-0.1-0.0
BMI without tail1.63.27.00.7-2.3-2.4-2.62.2-2.1-1.81.0-0.5-0.4
Body weight0.83.28.1-0.8-2.8-2.8-2.31.3-2.5-1.0-0.00.50.6
Weight adjusted by age0.40.42.20.6-0.1-0.1-0.80.5-1.50.0-0.30.50.6
Bone surface1.01.72.41.3-1.4-1.4-0.91.50.4-1.61.3-1.4-1.4
Bone volume1.22.03.21.8-1.7-1.7-1.41.7-0.3-1.51.3-1.1-1.1
Breakpoint value in progressive ratio session3.03.36.8-1.12.62.61.6-1.8-0.12.1-1.81.61.6
Number of licking bursts3.23.810.4-3.21.71.72.9-2.41.31.6-1.50.80.8
Context. condit. distance diff. score0.50.61.50.20.70.6-0.1-0.2-1.20.8-0.81.11.1
Locomotion velocity, session 10.70.72.60.51.61.60.7-0.70.50.7-0.50.30.2
Locomotion distance, session 11.31.74.90.50.90.8-0.5-0.3-2.21.2-1.41.81.8
Locomotion velocity, session 20.30.40.90.40.90.90.7-0.60.30.7-0.40.40.4
Locomotion distance, session 20.60.93.00.80.20.2-0.8-0.0-1.70.7-0.81.21.2
Locomotion velocity, session 30.20.30.8-0.20.90.80.2-0.2-0.40.5-0.40.60.6
Locomotion distance, session 30.00.00.2-0.40.20.20.2-0.10.10.1-0.10.10.0
Stereotopy head waving bouts, day 32.53.04.1-1.51.91.91.4-1.8-0.72.0-1.91.91.9
Stereotopy head waving duration, day 31.01.12.5-0.11.61.61.0-1.1-0.11.3-0.91.01.0
Locomotion velocity, session 70.40.51.00.5-0.4-0.4-0.00.60.9-0.80.7-1.0-1.0
Locomotion distance, session 70.10.20.4-0.5-0.5-0.50.3-0.10.6-0.3-0.1-0.4-0.4
Stereotopy head waving bouts, day 71.71.95.8-0.72.42.31.2-1.0-0.21.3-1.21.01.0
Stereotopy head waving duration, day 70.30.31.20.11.11.10.0-0.1-0.40.4-0.30.50.4
Locomotion velocity, session 80.81.02.0-1.21.01.11.4-1.20.70.8-0.90.50.5
Locomotion distance, session 80.91.34.30.90.40.4-0.80.0-2.11.0-0.91.51.6
Degree of sensitization distance0.10.10.3-0.4-0.3-0.30.3-0.4-0.20.2-0.60.30.3
Degree of sensitization stereotypy1.21.34.9-0.82.22.10.8-0.6-0.00.8-0.80.70.6
Conditioned locomotion0.10.10.40.6-0.0-0.1-0.40.5-0.5-0.10.20.10.1
Cocaine response after cond. corrected0.30.32.21.50.10.1-0.30.50.3-0.30.6-0.4-0.4
Cocaine response after cond. not corrected2.32.55.72.4-1.5-1.5-1.61.80.1-1.61.7-1.4-1.3
Cocaine response before conditioning3.54.39.60.9-3.1-3.1-2.02.2-0.2-2.31.8-1.7-1.7
Saline control response1.21.53.51.4-1.9-1.8-1.31.3-0.9-1.00.8-0.5-0.4
Bone: connectivity density0.81.32.30.8-1.5-1.5-0.71.10.4-1.51.0-1.2-1.2
Bone: cortical apparent density0.40.52.20.20.60.71.2-0.51.50.40.3-0.4-0.4
Bone: cortical area1.82.74.51.7-2.1-2.1-2.02.0-0.8-1.61.4-1.0-1.0
Bone: cortical porosity1.11.23.60.3-1.9-1.9-1.21.1-0.5-1.10.7-0.6-0.6
Bone: cortical porosity0.40.41.4-0.1-1.2-1.2-0.60.6-0.6-0.50.2-0.1-0.1
Bone: cortical thickness0.61.02.01.4-1.1-1.0-1.31.3-0.7-0.80.7-0.4-0.4
Bone: cortical thickness0.00.00.10.30.20.2-0.20.3-0.3-0.0-0.10.10.1
Bone: cortical tissue density0.40.62.30.20.70.81.2-0.51.50.40.3-0.4-0.3
Condit. Reinf. active minus inactive responses0.60.74.92.20.60.6-0.60.5-0.80.20.00.20.2
Condit. Reinf. active-inactive response ratio1.31.49.33.10.10.0-1.11.4-0.8-0.50.8-0.4-0.3
Condit. Reinf. active responses0.20.20.40.60.50.4-0.0-0.2-0.60.4-0.50.50.5
Condit. Reinf. inactive responses0.70.83.8-2.0-0.9-0.80.2-0.8-0.40.4-0.90.70.7
Incentive salience index mean0.91.15.22.3-0.1-0.2-1.01.10.1-1.01.0-0.9-0.9
Condit. Reinf. lever presses0.60.71.40.9-0.2-0.3-0.40.70.9-1.11.1-1.2-1.2
Condit. Reinf. active minus inactive responses2.02.58.4-1.6-0.6-0.6-0.6-0.5-2.91.1-1.72.12.1
Condit. Reinf. active-inactive response ratio1.81.94.6-2.0-0.4-0.3-0.1-0.6-2.11.0-1.61.81.8
Condit. Reinf. active responses1.01.45.4-1.0-0.8-0.8-0.7-0.2-2.30.6-1.21.51.5
Condit. Reinf. inactive responses0.60.81.70.9-1.3-1.3-0.90.8-0.0-0.90.7-0.7-0.7
Condit. Reinf. lever presses1.52.17.30.4-1.9-1.8-1.91.2-2.7-0.5-0.30.80.8
Condit. Reinf. lever reinforcers received1.11.55.6-1.0-0.8-0.7-0.5-0.2-2.40.7-1.31.51.6
Conditioned reinforcement - actives0.20.20.5-0.6-0.4-0.20.5-0.70.30.2-0.70.0-0.0
Conditioned reinforcement - inactives0.40.51.91.40.20.30.4-0.21.1-0.00.1-0.7-0.8
Conditioned locomotion0.40.51.3-1.20.60.70.8-0.90.40.5-0.90.30.3
Patch foraging indifference point 0 sec1.22.04.9-2.20.50.61.5-1.8-0.31.5-1.71.41.4
Patch foraging indifference point AUC1.61.83.21.7-1.4-1.4-1.81.8-0.9-1.41.1-0.8-0.8
Delay disc. indifference point, 0s delay0.10.10.20.40.40.4-0.40.20.2-0.40.2-0.4-0.5
Delay disc. indifference point, 16s delay1.11.12.30.11.51.51.4-1.10.71.2-0.90.50.4
Delay disc. indifference point, 2s delay0.40.41.3-0.2-1.1-1.0-0.6-0.1-0.8-0.1-0.70.40.4
Delay disc. indifference point, 24s delay1.31.33.81.90.50.60.20.41.8-0.41.1-1.3-1.3
Delay disc. indifference point, 4s delay0.40.41.60.6-1.3-1.1-0.60.3-0.2-0.20.1-0.2-0.2
Delay disc. indifference point, 8s delay0.20.20.60.8-0.3-0.20.3-0.00.8-0.00.2-0.5-0.6
Indifference point function ln k0.30.41.3-1.10.50.50.6-0.80.10.7-0.50.50.5
Indifference point function log k0.30.41.3-1.10.50.50.6-0.80.10.7-0.50.50.5
Patch foraging total patch changes 0 sec1.42.26.4-2.50.30.41.4-1.8-0.51.5-1.71.51.5
Patch foraging total patch changes 12 sec0.40.51.6-1.30.30.30.9-0.80.20.6-0.70.40.4
Patch foraging total patch changes 18 sec0.30.41.7-0.80.50.61.3-0.60.70.3-0.4-0.0-0.0
Patch foraging total patch changes 24 sec0.10.10.3-0.40.10.10.2-0.2-0.60.2-0.60.50.4
Patch foraging total patch changes 6 sec0.91.42.7-0.50.70.71.0-1.2-1.01.5-1.71.51.5
Patch foraging time to switch 0 sec1.42.14.8-0.72.22.12.0-1.52.00.9-0.5-0.1-0.2
Patch foraging water rate 0 sec0.20.31.5-1.2-0.5-0.50.2-0.2-0.60.1-0.40.50.6
Patch foraging water rate 12 sec0.61.02.7-1.3-1.6-1.6-0.90.5-1.1-0.60.00.20.2
Patch foraging water rate 18 sec0.60.81.40.4-1.2-1.2-1.11.2-1.1-0.90.5-0.2-0.1
Patch foraging water rate 24 sec0.20.20.6-0.8-0.7-0.70.30.10.3-0.50.3-0.4-0.3
Patch foraging water rate 6 sec0.60.94.8-2.2-0.2-0.11.1-1.00.00.6-0.80.70.7
Seeking ratio, delayed vs. immediate footshock0.70.81.30.1-1.1-1.1-0.30.60.9-1.00.8-1.0-1.0
Distance traveled before self-admin2.52.68.1-2.80.90.91.3-2.1-0.11.5-1.91.51.4
Distance traveled after self-admin1.11.23.9-2.00.60.60.9-1.3-0.30.8-1.41.01.0
Extensor digitorum longus weight2.28.612.81.3-3.6-3.6-2.62.71.6-3.43.1-3.2-3.3
Bone: elastic displacement2.83.25.3-0.92.32.31.8-2.00.02.2-1.81.61.6
Bone: elastic work0.50.71.2-0.50.60.60.6-1.0-0.31.1-1.11.00.9
Bone: endosteal estimation0.51.12.50.3-1.6-1.6-1.01.00.1-1.20.9-1.0-1.0
Bone: endosteal perimeter0.81.72.61.0-1.6-1.6-1.31.40.2-1.51.3-1.3-1.3
Epididymis fat weight0.40.82.40.8-0.8-0.8-1.61.0-1.5-0.30.30.30.4
Delta time in closed arm before/after self-admin0.40.40.70.4-0.6-0.6-0.30.60.5-0.50.8-0.7-0.7
Delta time in open arm before/after self-admin0.40.31.50.80.30.2-0.80.4-1.2-0.1-0.10.30.4
Diff in mean of infusions in LGA sessions3.64.08.0-2.81.01.00.9-2.2-1.22.2-2.42.52.4
Delay discount exponential model param0.30.31.0-0.81.00.80.2-0.2-0.30.2-0.10.40.5
Extinction: sum of active levers before priming0.30.31.41.2-0.0-0.0-0.80.4-0.70.1-0.00.20.2
Active lever presses in extinction session 60.50.51.50.2-0.9-0.8-0.8-0.0-1.20.4-0.50.80.8
Bone: final force1.32.13.91.6-2.0-1.9-1.81.7-0.4-1.31.2-1.0-1.0
Bone: final moment0.91.52.81.5-1.6-1.6-1.71.4-0.7-1.00.8-0.6-0.6
Food consumed during 24 hour testing period0.50.61.8-0.50.20.2-0.2-0.4-1.30.6-1.01.11.1
Glucose0.30.52.6-1.6-0.1-0.00.6-0.80.10.7-0.60.60.6
Heart weight0.10.10.30.5-0.3-0.3-0.40.1-0.20.1-0.10.10.1
Delay discount hyperbolic model param0.30.31.2-0.71.10.90.3-0.2-0.20.2-0.10.30.4
Intermittent access intake day 1-15 change0.40.41.5-0.60.70.70.7-0.31.20.00.1-0.4-0.5
Intermittent access intake escalation0.40.31.7-0.20.60.50.5-0.11.3-0.20.3-0.6-0.7
Intermittent access intake escalation 20.50.51.60.20.10.1-0.00.41.3-0.80.7-1.0-1.1
Intermitt. access day 1 inactive lever presses1.41.53.41.9-0.5-0.5-0.11.11.3-1.11.5-1.6-1.6
Intermitt. access day 15 inactive lever presses0.80.96.52.50.60.6-0.60.7-0.70.20.00.00.0
Intermitt. access escalation Index2.11.82.61.3-1.5-1.4-1.01.01.1-1.51.4-1.6-1.6
Intermittent access day 1 total infusions0.20.31.00.2-1.0-0.8-0.5-0.0-0.70.2-0.40.20.2
Intermittent access day 15 total infusions0.10.10.20.2-0.2-0.2-0.10.00.5-0.10.1-0.4-0.5
Intermittent access terminal intake (last 3 days)0.20.20.60.6-0.8-0.6-0.70.2-0.1-0.20.0-0.3-0.4
Intermittent access total infusions0.20.20.70.3-0.8-0.7-0.30.10.3-0.20.0-0.4-0.5
Intermittent access day 1 locomotion0.70.82.0-0.8-1.0-0.8-0.8-0.2-1.40.5-0.80.90.9
Intermittent access day 15 total locomotion1.11.12.9-1.7-0.1-0.0-0.1-0.9-1.10.9-1.51.31.3
Intermittent access total locomotion0.60.72.1-0.6-0.8-0.7-0.8-0.1-1.50.5-0.90.90.9
Intermittent access standard deviation0.50.54.4-2.1-0.3-0.30.1-0.60.20.0-0.60.20.2
Left kidney weight2.26.316.30.5-4.0-4.0-3.52.4-2.0-2.41.1-0.8-0.7
Right kidney weight3.28.919.41.2-4.4-4.4-4.23.2-1.9-3.11.9-1.4-1.3
Cocaine induced anxiety0.20.31.00.5-0.3-0.4-1.00.7-0.4-0.40.5-0.3-0.3
Post-drug Anxiety0.50.61.20.5-0.3-0.30.00.41.1-0.80.9-1.1-1.1
Baseline Anxiety0.91.04.6-0.20.40.41.4-0.52.1-0.40.4-1.1-1.1
Tail length0.51.63.01.7-1.3-1.4-1.61.5-0.7-1.31.1-0.8-0.7
Length with tail0.20.82.5-0.0-1.6-1.5-1.10.4-1.3-0.1-0.20.50.5
Length without tail0.51.12.6-1.6-0.00.10.5-1.1-0.71.1-1.41.31.3
Times rat made contact with spout0.40.40.8-0.60.90.90.7-0.80.50.4-0.70.20.1
Lifetime Intake0.20.20.9-0.3-0.9-0.8-0.3-0.3-0.20.1-0.40.0-0.0
Liver weight, left1.42.27.2-1.4-2.7-2.6-1.31.0-1.7-0.90.20.20.2
Liver weight, right2.03.28.50.8-2.9-2.9-2.22.0-1.5-1.31.3-0.5-0.4
Locomotor activity0.30.53.11.8-0.4-0.3-0.70.8-0.80.10.40.10.1
Locomotor testing distance0.30.61.2-0.50.10.20.1-0.4-1.11.1-0.81.11.1
Locomotor testing rearing0.30.50.8-0.90.00.10.2-0.4-0.90.8-0.80.90.9
Locomotion in novel chamber1.51.84.80.3-2.2-2.2-1.31.2-0.0-1.41.2-1.0-1.0
Locomotion in novel chamber post-restriction5.36.416.3-4.01.21.31.6-2.6-1.42.5-3.03.03.0
Fecal boli incidents, locomotor time 12.52.75.62.4-1.8-1.8-1.62.1-0.4-1.51.7-1.2-1.1
Change in fecal boli incidents, locomotor task1.11.12.0-1.40.80.80.8-1.3-0.31.2-1.31.11.0
Time >=10cm from walls, locomotor time 11.01.11.6-0.91.31.20.7-1.1-0.31.1-1.21.11.0
Bouts of movement, locomotor time 10.40.50.91.0-0.9-0.9-0.90.8-0.6-0.50.4-0.2-0.2
Total resting periods, locomotor time 10.30.31.10.5-1.0-1.0-0.30.5-0.1-0.30.4-0.3-0.3
Rest time, locomotor task time 10.60.61.60.4-1.3-1.20.30.20.9-0.30.8-0.8-0.7
Distance moved, locomotor task time 11.31.52.5-1.21.61.50.3-0.9-1.01.1-1.51.41.3
Vertical activity count, locomotor time 12.32.47.6-1.02.82.71.4-1.40.51.1-1.40.80.6
Time >=10cm from walls, locomotor time 20.70.83.31.80.30.2-1.31.0-0.1-0.60.7-0.6-0.7
Bouts of movement, locomotor time 22.02.24.42.1-1.9-1.9-1.61.7-0.8-1.11.3-0.8-0.7
Total resting periods, locomotor time 21.92.04.81.5-2.2-2.1-1.41.5-0.7-1.11.2-0.8-0.7
Rest time, locomotor task time 20.60.62.8-1.70.00.00.9-1.10.30.7-0.70.50.5
Distance moved, locomotor task time 20.30.41.70.21.31.20.0-0.30.20.3-0.40.20.1
Vertical activity count, locomotor time 20.60.72.20.81.51.40.6-0.31.10.2-0.0-0.3-0.4
Light reinforcement 10.40.71.8-0.01.31.31.1-0.71.10.6-0.2-0.0-0.1
Light reinforcement 20.40.61.90.11.41.30.6-0.50.10.8-0.40.50.5
Bone: marrow area0.51.02.30.3-1.5-1.5-0.91.00.1-1.20.8-0.9-1.0
Bone: maximum diameter1.11.94.50.6-2.1-2.1-1.61.6-0.6-1.51.0-0.9-0.9
Bone: maximum force1.11.94.71.3-2.2-2.1-1.61.4-0.4-1.20.9-0.8-0.9
Bone: maximum moment0.71.33.21.2-1.8-1.7-1.51.2-0.7-0.80.5-0.4-0.5
Mean time between licks in bursts0.50.81.9-0.2-1.2-1.2-1.40.8-1.3-0.40.20.30.3
Mean num. licks in bursts1.72.17.72.8-0.8-0.9-2.21.7-0.9-1.10.9-0.6-0.6
Cd content in liver1.31.43.2-1.21.81.71.4-1.00.21.0-0.90.80.8
Co content in liver0.70.83.51.91.00.9-0.0-0.1-0.80.9-0.20.80.9
Cu content in liver1.11.34.90.30.80.7-0.70.1-2.20.8-1.11.51.5
Fe content in liver0.60.71.41.01.11.10.70.11.2-0.10.8-0.7-0.6
K content in liver5.65.513.83.7-2.2-2.2-3.22.9-1.8-1.92.0-1.1-0.9
Mg content in liver2.82.97.82.8-1.3-1.4-2.42.0-2.3-0.81.00.00.2
Mn content in liver2.12.43.41.7-1.6-1.5-1.61.8-0.0-1.81.6-1.4-1.4
Na content in liver1.71.82.91.2-1.7-1.7-1.31.4-0.0-1.61.2-1.2-1.2
Rb content in liver0.91.13.80.70.80.6-0.5-0.1-2.00.8-0.91.31.4
Se content in liver1.51.83.11.8-1.6-1.5-1.21.6-0.1-1.31.5-1.1-1.0
Sr content in liver0.60.51.1-1.1-1.0-1.0-0.30.30.3-0.90.3-0.6-0.7
Zn content in liver2.42.76.92.6-1.4-1.4-2.51.6-2.5-0.50.40.40.5
Bone: minimum diameter0.61.11.61.1-1.2-1.2-1.31.2-0.3-1.10.9-0.9-0.9
Time in familiar zone, hab. session 10.20.20.6-0.30.30.40.5-0.5-0.20.5-0.80.50.5
Time in novel zone, hab. session 10.00.00.2-0.40.00.00.1-0.30.20.20.10.00.0
Total zone transitions, hab. session 10.60.81.60.61.11.0-0.3-0.2-1.30.8-1.01.11.1
Total locomotion distance, hab. session 11.01.44.20.70.50.4-0.8-0.3-2.11.0-1.31.61.6
Locomotion velocity, hab. session 10.91.34.00.50.40.4-0.6-0.3-2.01.0-1.21.61.6
Time in familiar zone, hab. session 20.30.30.8-0.5-0.1-0.0-0.3-0.5-0.70.6-0.90.80.7
Time in novel zone, hab. session 20.90.91.71.2-0.9-0.9-0.41.00.4-0.91.3-1.0-0.9
Total zone transitions, hab. session 21.31.76.01.30.90.8-1.10.3-2.40.8-1.01.61.6
Total locomotion distance, hab. session 21.21.64.61.90.80.8-1.00.2-2.10.7-0.91.41.4
Locomotion velocity, hab. session 21.21.64.81.40.80.8-0.90.0-2.20.9-1.11.61.6
Novel to familiar place preference ratio0.80.92.60.60.20.2-0.8-0.2-1.60.9-0.81.31.3
Novelty place preference0.70.72.10.40.30.3-0.7-0.2-1.40.9-0.71.21.2
Time in novel zone, NPP test0.90.92.80.50.40.4-0.8-0.2-1.71.0-0.81.41.4
Total zone transitions, NPP test0.40.52.00.30.20.2-0.70.0-1.40.4-0.81.00.9
Total locomotion distance, NPP test0.50.72.51.10.00.1-0.90.2-1.60.4-0.70.90.9
Locomotion velocity, NPP test0.40.52.00.9-0.2-0.2-0.90.3-1.40.2-0.60.70.7
Intraocular pressure0.50.71.6-0.4-1.0-0.90.40.21.3-0.70.9-0.9-0.9
Delta distance traveled before/after self-admin0.20.20.70.9-0.4-0.4-0.50.6-0.6-0.40.3-0.1-0.1
Delta ambulatory time before/after self-admin0.20.20.80.9-0.4-0.4-0.30.5-0.0-0.50.4-0.4-0.4
Parametrial fat weight1.12.26.2-1.1-2.5-2.5-1.41.2-0.4-1.71.0-0.8-0.8
Pavlov. Cond. lever latency1.51.83.4-0.90.80.90.9-1.2-1.11.8-1.61.81.8
Pavlov. Cond. magazine entry latency3.24.18.31.6-2.9-2.9-2.52.2-0.9-2.11.5-1.3-1.2
Pavlov. Cond. change in total contacts4.24.57.61.7-1.8-1.8-1.32.11.4-2.82.4-2.7-2.7
Pavlov. Cond. index score2.63.35.60.8-2.2-2.2-1.81.90.3-2.41.9-1.9-1.9
Pavlov. Cond. latency score2.53.25.60.9-1.9-2.0-1.81.90.4-2.41.9-1.9-1.9
Pavlov. Cond. lever contacts2.22.65.11.0-1.3-1.3-1.41.60.9-2.31.9-2.0-2.0
Pavlov. Cond. magazine entry number2.43.04.9-1.22.22.21.9-1.90.22.1-1.61.51.5
Pavlov. Cond. intertrial magazine entries0.30.41.00.00.60.71.0-0.6-0.10.7-0.80.50.5
Pavlov. Cond. lever-magazine prob. diff.2.73.45.60.8-2.3-2.4-1.81.90.2-2.41.8-1.8-1.8
Pavlov. Cond. response bias2.12.54.10.8-2.0-2.0-1.51.60.4-2.01.6-1.6-1.6
Pavlov. Cond. lever latency1.62.18.5-0.51.51.52.1-0.82.90.20.5-1.0-1.1
Pavlov. Cond. magazine entry latency0.60.71.40.8-0.2-0.3-0.11.00.5-1.21.0-1.2-1.1
Pavlov. Cond. change in total contacts1.21.66.7-0.4-0.7-0.7-0.7-0.1-2.60.8-1.31.71.7
Pavlov. Cond. index score0.50.72.30.6-1.0-1.0-1.00.9-1.5-0.50.10.20.2
Pavlov. Cond. latency score0.60.71.50.7-1.1-1.0-1.01.1-1.2-0.80.3-0.1-0.1
Pavlov. Cond. lever contacts2.12.97.91.3-2.2-2.1-2.61.6-2.8-0.90.20.40.5
Pavlov. Cond. magazine entry number0.10.10.20.2-0.2-0.2-0.40.00.4-0.10.3-0.2-0.3
Pavlov. Cond. intertrial magazine entries3.14.08.41.8-2.9-2.9-2.62.1-1.1-1.81.6-1.0-0.9
Pavlov. Cond. lever-magazine prob. diff.0.70.82.10.9-1.1-1.1-1.21.1-1.5-0.70.30.00.1
Pavlov. Cond. response bias1.01.35.00.7-1.2-1.2-1.61.0-2.2-0.5-0.20.50.6
Time in closed arm before self-admin0.30.40.9-0.9-0.6-0.6-0.3-0.4-0.80.3-0.60.60.6
Time in closed arm after self-admin0.10.10.5-0.3-0.3-0.30.2-0.20.70.00.2-0.3-0.3
Time in open arm before self-admin0.40.41.51.20.40.40.10.50.8-0.40.7-0.7-0.7
Time in open arm after self-admin0.80.93.31.80.0-0.1-1.11.3-0.4-1.00.9-0.8-0.8
Bone: periosteal estimation1.53.15.81.3-2.4-2.4-1.92.0-0.3-1.91.6-1.4-1.4
Bone: periosteal perimeter1.52.45.61.1-2.4-2.3-1.91.7-0.8-1.51.2-0.9-0.8
Bone: post-yield work1.11.53.50.7-1.9-1.8-1.81.2-1.6-0.70.30.10.1
Progressive ratio test 1 active lever presses0.10.10.3-0.6-0.6-0.5-0.3-0.1-0.40.2-0.30.20.2
Progressive ratio test 1 breakpoint0.20.20.7-0.8-0.8-0.7-0.4-0.1-0.50.0-0.30.20.1
Progressive ratio test 1 inactive lever presses0.50.61.0-0.9-0.10.00.5-0.9-0.51.0-1.00.90.9
Progressive ratio test 2 active lever presses0.10.10.3-0.40.20.30.1-0.50.20.4-0.50.10.1
Progressive ratio test 2 breakpoint0.10.10.3-0.60.20.20.0-0.50.00.5-0.50.20.2
Progressive ratio test 2 inactive lever presses0.50.63.51.9-0.4-0.4-0.80.7-0.5-0.10.3-0.3-0.3
Incentive Sensitization - Responses0.30.30.90.21.01.00.1-0.40.60.5-0.3-0.0-0.1
Incentive Sensitization - Breakpoint0.30.31.20.21.11.10.2-0.40.60.5-0.30.0-0.1
Sum of active levers in priming session hrs 5-60.70.71.8-0.5-0.4-0.4-0.7-0.4-1.30.8-0.81.11.1
Progressive ratio0.91.02.0-1.40.90.90.7-1.1-0.41.0-1.21.11.1
Food seeking constrained by brief footshock0.00.10.10.40.30.3-0.1-0.3-0.00.3-0.30.10.1
Seeking ratio, punishment vs. effort1.01.22.51.6-1.2-1.2-1.01.10.1-1.01.1-1.0-1.0
Retroperitoneal fat weight0.41.34.3-1.3-2.1-2.1-0.90.7-1.2-0.60.30.10.2
Reaction time number correct0.50.74.8-2.2-0.8-0.80.6-0.20.2-0.20.0-0.1-0.1
Reaction time mean minus median0.81.04.02.0-0.6-0.6-1.11.10.0-0.90.9-0.9-0.9
Reaction time mean minus median AUC0.60.83.01.7-0.4-0.4-1.11.1-0.5-0.70.7-0.5-0.5
Reaction time num false alarms0.40.51.8-1.20.40.40.8-0.61.4-0.1-0.0-0.4-0.5
Reaction time num false alarms AUC0.30.51.8-1.30.10.10.7-0.61.3-0.10.1-0.4-0.5
Reaction time trials correct on left0.50.74.8-2.2-0.8-0.80.6-0.20.2-0.20.0-0.1-0.1
Reaction time trials on left0.40.64.5-2.1-0.8-0.70.6-0.20.2-0.20.0-0.1-0.1
Reaction time mean0.71.06.52.50.20.2-1.00.9-0.2-0.40.7-0.5-0.5
Reaction time mean AUC0.50.74.82.20.00.0-0.70.80.1-0.30.7-0.5-0.5
Median of all reaction times0.50.75.22.30.50.5-0.70.7-0.3-0.10.5-0.2-0.2
Reaction time omissions0.40.53.81.90.50.5-0.60.6-0.30.00.5-0.1-0.1
Reaction time false alarm rate0.20.31.60.10.50.50.3-0.31.3-0.10.3-0.6-0.6
Reaction time premature initiation rate3.74.917.04.1-1.4-1.4-1.92.50.3-2.22.2-2.1-2.1
Reaction time premature initiations2.53.66.22.5-1.5-1.5-1.22.20.7-2.22.1-2.2-2.2
Std. dev. reaction times1.52.110.03.2-0.3-0.3-1.31.50.2-1.11.4-1.3-1.3
Reaction time trials completed0.40.64.5-2.1-0.8-0.70.6-0.20.2-0.20.0-0.1-0.1
Reaction time trials AUC0.40.63.8-2.0-0.9-0.90.4-0.10.2-0.30.1-0.2-0.1
Run reversals in cocaine runway, females1.71.64.2-2.0-2.0-1.8-0.1-0.31.3-1.00.1-0.9-1.0
Run reversals in cocaine runway, males10.09.727.0-5.23.13.03.6-4.01.82.6-2.61.81.7
Latency to leave start box in cocaine runway2.83.010.3-3.21.31.22.0-2.00.31.5-1.61.41.3
Latency to leave start box in cocaine runway, F1.51.68.2-2.90.90.81.3-1.30.20.8-0.90.90.9
Latency to leave start box in cocaine runway, M2.01.95.0-1.31.41.42.2-1.81.21.3-1.10.60.6
Std. dev. time between licks in bursts1.31.64.8-0.4-2.2-2.1-1.21.3-0.6-1.11.1-0.6-0.5
Total sessions with >9 infusions0.40.50.9-0.9-0.9-0.7-0.1-0.6-0.70.4-1.00.60.6
Short access day 1 total inactive lever presses0.50.62.71.6-1.1-0.9-0.40.6-0.2-0.10.4-0.4-0.4
Short access day 10 total inactive lever presses1.82.014.13.8-0.3-0.2-0.81.5-0.1-0.41.0-0.8-0.8
Short access day 1 total infusions0.40.40.8-0.6-0.6-0.5-0.2-0.5-0.90.6-0.80.80.8
Short access day 10 total infusions0.40.41.0-0.7-1.0-0.8-0.0-0.4-0.70.3-0.80.50.5
Short access total infusions0.60.61.1-0.9-1.1-0.9-0.4-0.4-1.10.5-0.80.70.7
Short access day 1 locomotion1.11.12.2-1.5-0.10.10.4-1.1-0.91.2-1.41.31.3
Short access day 10 total locomotion1.72.08.80.2-1.2-1.1-1.90.9-3.00.2-0.31.21.3
Short access total locomotion1.51.65.6-1.1-1.0-0.9-1.1-0.1-2.40.7-0.91.51.6
One hour access (0.3 mA shock)0.40.51.30.2-1.1-1.1-1.10.5-0.2-0.60.4-0.4-0.5
Compulsive drug intake0.20.20.7-0.80.20.10.1-0.4-0.60.3-0.50.70.7
One hour access (shock baseline)0.40.50.91.0-0.8-0.7-0.70.40.5-0.40.4-0.7-0.8
Social response proportion1.81.97.32.7-0.8-0.8-1.81.9-1.3-0.81.2-0.4-0.3
Social responses0.30.40.90.31.01.00.4-0.4-0.00.9-0.30.50.5
Social time0.30.41.41.00.30.3-0.30.5-1.20.5-0.10.50.5
Soleus weight0.72.23.51.2-1.9-1.9-1.81.7-0.0-1.71.3-1.3-1.3
Bone: stiffness1.82.85.21.8-2.3-2.2-1.71.70.3-1.61.5-1.4-1.5
Tibialis anterior weight1.96.513.21.7-3.6-3.6-3.12.7-0.2-2.72.2-2.0-2.0
Time to tail flick, vehicle, before self-admin0.40.42.2-1.50.30.30.3-0.90.30.5-0.60.50.4
Time to tail flick, vehicle, after self-admin3.23.514.6-3.80.80.81.5-2.1-0.41.6-1.81.71.8
Time to tail flick, test, before self-admin0.10.10.4-0.40.60.60.2-0.10.20.0-0.1-0.0-0.1
Time to tail flick, test, after self-admin0.10.10.9-0.90.20.10.00.10.4-0.30.2-0.3-0.4
Delta time to tail flick, vehicle, before/after SA0.20.20.8-0.9-0.2-0.2-0.10.0-0.80.2-0.30.50.6
Delta time to tail flick, test, before/after SA0.20.20.6-0.1-0.7-0.8-0.40.4-0.3-0.30.3-0.1-0.1
Tibia length0.30.84.72.20.40.4-1.11.0-0.5-0.30.6-0.2-0.1
Ambulatory time before self-admin3.53.610.3-3.21.51.51.8-2.50.51.8-2.01.51.5
Ambulatory time after self-admin1.51.76.2-2.50.80.81.5-1.80.80.8-1.30.70.6
Bone: tissue strength0.10.10.2-0.2-0.5-0.4-0.0-0.2-0.20.2-0.40.20.2
Total heroin consumption2.32.74.3-0.81.71.70.7-1.2-1.61.8-1.92.12.1
Bone: trabecular number0.10.10.30.2-0.5-0.5-0.00.0-0.1-0.3-0.3-0.1-0.1
Bone: trabecular spacing0.30.41.00.5-0.1-0.2-0.70.90.0-0.81.0-0.7-0.6
Bone: trabecular thickness0.60.72.70.7-0.9-0.9-0.90.5-1.60.1-0.30.70.8
Bone: trabecular tissue density0.10.20.40.50.60.50.40.20.70.10.4-0.3-0.3
Water consumed over 24 hours1.41.74.2-1.71.41.42.1-1.51.50.8-0.80.10.1
Number of responses in last shaping day0.80.92.21.0-1.5-1.3-0.20.60.5-0.70.9-1.0-0.9