Hub : Genes

Crtc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Crtc3	0.03	0.02	7.3e-03	0	0.01	0.01	0	1.9e-01	3.7e-02	2.9e-02	9.6e-02
2	Adipose	gene expression	Crtc3	0.04	0.03	7.2e-03	-0	0	0	-0	8.5e-01	1.8e-01	8.8e-02	6.8e-01
3	pVTA	gene expression	Crtc3	0.11	0.06	3.2e-03	0.05	0.04	0.03	0.04	4.5e-03	6.2e-03	1.7e-02	1.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.0	1.7	3.5	-1.9	-1.2	0.4
Area under the delay curve	0.7	0.7	2.1	0.3	1.4	0.3
BMI with tail	1.8	5.7	11.1	3.3	-1.5	-2.0
BMI without tail	0.5	1.0	2.0	1.4	1.0	0.4
Body weight	0.5	1.9	3.3	1.8	0.1	-1.6
Weight adjusted by age	0.2	0.2	0.5	-0.7	-0.3	0.3
Bone surface	1.6	2.8	6.2	-2.5	-0.0	1.5
Bone volume	1.4	2.4	5.5	-2.3	-0.4	1.2
Breakpoint value in progressive ratio session	0.3	0.4	0.8	0.9	0.5	-0.1
Number of licking bursts	0.7	0.8	1.8	-1.3	0.3	0.8
Context. condit. distance diff. score	0.1	0.2	0.4	-0.6	-0.1	0.4
Locomotion velocity, session 1	0.6	0.7	1.1	0.7	1.0	-0.6
Locomotion distance, session 1	0.5	0.6	1.8	0.3	1.3	0.1
Locomotion velocity, session 2	0.3	0.3	0.8	0.5	0.9	-0.2
Locomotion distance, session 2	0.3	0.4	1.0	-0.3	1.0	0.3
Locomotion velocity, session 3	2.8	3.2	4.8	-1.1	2.2	1.9
Locomotion distance, session 3	4.7	5.1	8.2	-1.6	2.9	2.1
Stereotopy head waving bouts, day 3	0.8	0.9	1.9	-1.4	-0.8	-0.4
Stereotopy head waving duration, day 3	0.3	0.3	0.5	-0.2	-0.7	0.7
Locomotion velocity, session 7	1.3	1.5	4.2	0.2	2.0	0.4
Locomotion distance, session 7	0.6	0.7	1.2	-0.4	1.1	0.9
Stereotopy head waving bouts, day 7	0.9	1.0	2.8	-1.7	-0.2	0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.6	-0.7	0.4	0.7
Locomotion velocity, session 8	0.8	0.9	2.6	1.6	0.3	-0.2
Locomotion distance, session 8	0.4	0.6	1.3	-0.5	1.1	0.5
Degree of sensitization distance	1.1	1.2	2.5	0.8	-1.6	-0.6
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.5	0.1	0.1
Conditioned locomotion	0.6	0.8	1.2	-0.3	-1.0	-1.1
Cocaine response after cond. corrected	0.8	1.0	1.6	0.7	-0.8	-1.3
Cocaine response after cond. not corrected	0.6	0.7	1.0	0.9	-0.4	-1.0
Cocaine response before conditioning	0.6	0.7	1.0	-0.5	1.0	0.9
Saline control response	4.0	5.3	13.5	-0.2	3.7	1.5
Bone: connectivity density	1.0	1.6	3.5	-1.9	-1.2	0.1
Bone: cortical apparent density	2.3	3.0	4.5	2.1	-0.3	-2.1
Bone: cortical area	1.6	2.4	4.9	-2.2	1.2	0.9
Bone: cortical porosity	0.8	0.8	2.2	-0.2	-1.5	0.5
Bone: cortical porosity	0.7	0.8	1.8	-0.3	-1.3	0.7
Bone: cortical thickness	0.3	0.4	0.7	-0.9	0.7	-0.2
Bone: cortical thickness	0.9	1.0	1.9	-0.1	-1.0	-1.4
Bone: cortical tissue density	2.3	3.1	4.6	2.1	-0.4	-2.1
Condit. Reinf. active minus inactive responses	0.7	0.8	1.2	0.5	1.1	-1.0
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.5	-1.6	1.3	1.0
Condit. Reinf. active responses	0.7	0.9	1.8	0.9	0.3	-1.3
Condit. Reinf. inactive responses	1.0	1.2	1.5	1.2	-0.9	-1.2
Incentive salience index mean	1.9	2.3	2.7	1.4	1.6	-1.5
Condit. Reinf. lever presses	3.5	4.7	6.8	2.6	1.8	-1.9
Condit. Reinf. active minus inactive responses	0.9	1.1	2.1	1.5	-0.5	-1.0
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.3	1.5	-1.4	-1.3
Condit. Reinf. active responses	0.5	0.7	1.1	1.0	1.0	-0.2
Condit. Reinf. inactive responses	3.4	4.2	10.8	-0.5	3.3	1.3
Condit. Reinf. lever presses	1.2	1.7	2.6	0.3	1.6	1.5
Condit. Reinf. lever reinforcers received	0.7	1.0	2.0	0.9	1.4	-0.2
Conditioned reinforcement - actives	0.1	0.1	0.2	0.1	-0.4	-0.3
Conditioned reinforcement - inactives	0.7	0.8	2.2	-1.5	0.2	0.5
Conditioned locomotion	0.2	0.2	0.5	0.1	-0.7	-0.2
Patch foraging indifference point 0 sec	0.7	1.2	1.6	-0.9	1.3	1.1
Patch foraging indifference point AUC	1.4	1.6	2.8	-1.7	-0.2	1.4
Delay disc. indifference point, 0s delay	0.2	0.2	0.5	0.2	-0.1	-0.7
Delay disc. indifference point, 16s delay	0.7	0.7	1.1	-0.6	1.1	0.7
Delay disc. indifference point, 2s delay	0.5	0.5	0.8	-0.1	0.9	0.9
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.4	0.6	0.2
Delay disc. indifference point, 4s delay	2.3	2.5	7.0	0.5	2.6	0.4
Delay disc. indifference point, 8s delay	0.5	0.5	0.7	0.9	0.8	-0.2
Indifference point function ln k	0.2	0.3	0.7	0.9	0.0	-0.3
Indifference point function log k	0.2	0.3	0.7	0.9	0.0	-0.3
Patch foraging total patch changes 0 sec	1.0	1.6	2.2	-1.2	1.1	1.5
Patch foraging total patch changes 12 sec	2.3	3.0	7.3	-2.7	-0.0	1.3
Patch foraging total patch changes 18 sec	2.4	3.1	6.4	-2.5	0.7	1.5
Patch foraging total patch changes 24 sec	1.8	2.2	2.7	-1.6	1.1	1.6
Patch foraging total patch changes 6 sec	1.0	1.5	1.8	-1.2	1.2	1.3
Patch foraging time to switch 0 sec	0.7	1.0	2.0	-1.4	0.7	0.7
Patch foraging water rate 0 sec	1.0	1.5	2.2	1.5	-1.3	-0.8
Patch foraging water rate 12 sec	4.3	6.6	16.0	4.0	0.5	-1.9
Patch foraging water rate 18 sec	1.7	2.3	6.0	2.5	-0.4	-0.9
Patch foraging water rate 24 sec	2.1	3.0	4.6	2.2	-1.1	-1.7
Patch foraging water rate 6 sec	2.6	3.8	7.4	2.7	-0.2	-2.0
Seeking ratio, delayed vs. immediate footshock	2.9	3.3	8.5	0.9	-0.8	-2.9
Distance traveled before self-admin	1.0	1.1	2.7	0.6	1.6	-0.3
Distance traveled after self-admin	2.2	2.5	5.7	-1.1	2.4	0.7
Extensor digitorum longus weight	0.2	0.6	1.7	1.3	0.2	-0.3
Bone: elastic displacement	3.9	4.4	8.7	1.9	-0.8	-3.0
Bone: elastic work	0.7	1.0	2.3	0.7	0.4	-1.5
Bone: endosteal estimation	3.0	6.6	13.2	-3.6	-0.3	2.6
Bone: endosteal perimeter	1.6	3.3	7.0	-2.6	-0.7	1.6
Epididymis fat weight	2.5	5.8	9.4	3.1	-0.4	-2.8
Delta time in closed arm before/after self-admin	1.7	1.7	4.5	0.7	-2.1	-0.2
Delta time in open arm before/after self-admin	0.3	0.3	0.7	0.8	0.4	-0.4
Diff in mean of infusions in LGA sessions	2.5	2.7	4.7	-1.3	2.2	1.4
Delay discount exponential model param	0.9	1.0	2.7	-0.3	-1.7	-0.3
Extinction: sum of active levers before priming	1.1	1.1	1.7	1.3	-0.8	-1.0
Active lever presses in extinction session 6	1.6	1.6	2.7	1.6	-0.1	-1.5
Bone: final force	0.7	1.2	2.7	-1.6	0.3	0.9
Bone: final moment	0.6	1.0	2.4	-1.5	0.2	0.7
Food consumed during 24 hour testing period	1.2	1.4	2.3	-1.4	0.2	1.5
Glucose	0.2	0.3	0.4	0.6	-0.6	-0.4
Heart weight	0.7	0.9	1.6	1.3	-0.5	-0.9
Delay discount hyperbolic model param	1.1	1.2	3.3	-0.2	-1.8	-0.5
Intermittent access intake day 1-15 change	0.4	0.4	0.6	-0.5	0.8	0.5
Intermittent access intake escalation	0.1	0.1	0.2	-0.4	0.2	0.3
Intermittent access intake escalation 2	0.7	0.7	1.4	-1.2	0.5	0.7
Intermitt. access day 1 inactive lever presses	1.5	1.6	2.7	1.6	0.4	-1.4
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	-0.1	-0.1	-0.5
Intermitt. access escalation Index	0.3	0.3	0.8	0.1	0.9	-0.0
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.2	-0.0	-0.3
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.0	0.2	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.3	-0.5	0.6	-0.1
Intermittent access total infusions	0.1	0.1	0.3	-0.0	0.2	-0.5
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.0	0.4	-0.6
Intermittent access day 15 total locomotion	0.4	0.4	0.8	0.3	0.5	-0.9
Intermittent access total locomotion	0.2	0.2	0.6	-0.8	-0.1	-0.1
Intermittent access standard deviation	2.3	2.4	4.8	-2.2	0.5	1.5
Left kidney weight	1.0	2.7	5.8	0.7	-2.4	-1.3
Right kidney weight	0.3	0.7	1.3	0.7	-1.1	-0.6
Cocaine induced anxiety	0.2	0.2	0.4	-0.4	-0.4	0.6
Post-drug Anxiety	0.1	0.1	0.1	0.3	-0.4	-0.1
Baseline Anxiety	2.1	2.3	3.5	1.7	0.5	-1.9
Tail length	1.4	4.2	7.6	-1.8	2.8	1.3
Length with tail	0.4	1.3	2.9	-1.0	1.7	-0.2
Length without tail	0.4	1.0	2.3	0.5	-0.6	-1.5
Times rat made contact with spout	1.4	1.6	2.8	1.7	-0.7	-1.2
Lifetime Intake	0.1	0.1	0.4	0.2	0.1	-0.6
Liver weight, left	2.1	3.3	4.1	1.7	-2.0	-1.7
Liver weight, right	0.7	1.1	2.5	0.9	-0.2	-1.6
Locomotor activity	0.4	0.7	1.6	0.2	-0.5	1.3
Locomotor testing distance	0.5	0.8	2.1	1.5	-0.6	0.2
Locomotor testing rearing	0.5	0.8	2.0	0.2	1.4	0.5
Locomotion in novel chamber	0.3	0.4	1.0	-0.1	1.0	0.5
Locomotion in novel chamber post-restriction	0.4	0.5	0.8	-0.4	-0.9	0.8
Fecal boli incidents, locomotor time 1	1.2	1.3	2.4	-0.2	-1.5	-1.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	-0.1	0.4	0.7
Time >=10cm from walls, locomotor time 1	1.3	1.3	2.7	1.7	0.3	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.1	0.4	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.1	0.1	0.4	-0.3
Rest time, locomotor task time 1	0.7	0.7	1.3	-1.2	0.9	0.1
Distance moved, locomotor task time 1	0.5	0.6	1.1	1.0	-0.8	-0.1
Vertical activity count, locomotor time 1	0.2	0.2	0.5	-0.1	-0.5	0.7
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.4	0.1	1.2	0.3
Bouts of movement, locomotor time 2	2.8	3.0	6.1	-2.5	-0.7	1.6
Total resting periods, locomotor time 2	3.3	3.5	7.4	-2.7	-1.0	1.5
Rest time, locomotor task time 2	0.9	1.1	1.4	-1.1	-1.2	-0.7
Distance moved, locomotor task time 2	0.6	0.7	1.5	-0.1	1.2	0.8
Vertical activity count, locomotor time 2	0.4	0.4	1.0	-0.2	0.3	1.0
Light reinforcement 1	3.1	5.7	14.7	-3.8	-0.1	1.5
Light reinforcement 2	1.1	1.5	4.0	-2.0	-0.5	0.3
Bone: marrow area	3.1	6.8	13.4	-3.7	-0.3	2.6
Bone: maximum diameter	2.9	5.3	10.0	-3.2	0.9	2.3
Bone: maximum force	0.8	1.4	3.1	-1.7	0.1	1.0
Bone: maximum moment	0.6	1.0	2.4	-1.6	-0.0	0.8
Mean time between licks in bursts	1.2	1.7	2.7	-1.3	-1.6	-0.8
Mean num. licks in bursts	3.4	4.0	7.0	2.7	-1.2	-1.9
Cd content in liver	1.9	2.0	4.4	-0.4	-2.1	-1.2
Co content in liver	0.7	0.9	1.2	0.5	-1.1	-1.1
Cu content in liver	0.4	0.5	1.0	0.7	1.0	-0.0
Fe content in liver	0.4	0.5	0.8	-0.9	0.5	0.6
K content in liver	3.2	3.2	4.1	-1.5	1.8	2.0
Mg content in liver	2.9	2.9	4.9	-1.4	1.4	2.2
Mn content in liver	0.4	0.4	1.1	0.4	-0.1	-1.0
Na content in liver	5.0	5.3	7.7	-2.1	1.9	2.8
Rb content in liver	0.3	0.4	0.5	0.3	0.7	0.7
Se content in liver	0.1	0.1	0.3	-0.5	-0.0	-0.1
Sr content in liver	0.3	0.3	0.8	-0.1	0.2	0.9
Zn content in liver	1.7	1.9	2.9	-1.5	0.5	1.7
Bone: minimum diameter	2.7	5.0	12.1	-3.5	-0.8	1.5
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.0	-0.0	0.7
Time in novel zone, hab. session 1	0.3	0.3	0.8	0.2	0.2	-0.9
Total zone transitions, hab. session 1	3.4	4.8	13.8	0.3	3.7	0.7
Total locomotion distance, hab. session 1	1.0	1.4	1.8	-1.0	1.2	-1.4
Locomotion velocity, hab. session 1	0.9	1.3	2.1	-0.8	1.1	-1.4
Time in familiar zone, hab. session 2	0.6	0.6	1.3	-1.1	-0.5	0.6
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.7	0.5	-0.4
Total zone transitions, hab. session 2	2.8	3.6	9.3	0.1	3.1	1.3
Total locomotion distance, hab. session 2	0.8	1.1	2.4	-1.5	0.8	-0.6
Locomotion velocity, hab. session 2	0.7	1.0	1.7	-1.3	0.8	-0.7
Novel to familiar place preference ratio	0.7	0.7	1.3	-1.1	-0.1	1.0
Novelty place preference	0.5	0.5	0.8	-0.9	-0.4	0.8
Time in novel zone, NPP test	0.3	0.3	0.5	-0.6	-0.4	0.7
Total zone transitions, NPP test	0.8	1.2	3.0	0.7	1.7	-0.1
Total locomotion distance, NPP test	1.3	1.7	4.2	-0.9	-0.4	-2.0
Locomotion velocity, NPP test	1.2	1.8	3.5	-1.2	-0.5	-1.9
Intraocular pressure	0.1	0.1	0.1	0.4	-0.3	-0.0
Delta distance traveled before/after self-admin	2.9	3.1	5.2	-2.3	0.6	1.9
Delta ambulatory time before/after self-admin	1.3	1.4	2.8	-1.7	0.1	1.2
Parametrial fat weight	3.2	6.2	11.0	3.3	0.1	-2.7
Pavlov. Cond. lever latency	1.9	2.4	3.5	-1.5	-1.9	1.3
Pavlov. Cond. magazine entry latency	2.0	2.6	3.3	1.1	1.8	-1.8
Pavlov. Cond. change in total contacts	2.3	2.5	5.0	0.6	1.5	-2.2
Pavlov. Cond. index score	2.4	3.1	3.7	1.6	1.9	-1.8
Pavlov. Cond. latency score	2.5	3.2	4.5	1.6	2.1	-1.6
Pavlov. Cond. lever contacts	1.6	1.8	3.0	1.1	1.7	-1.1
Pavlov. Cond. magazine entry number	2.4	3.0	3.4	-1.6	-1.8	1.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.2	0.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.4	4.2	1.7	1.7	-2.0
Pavlov. Cond. response bias	1.3	1.6	3.1	0.9	1.0	-1.8
Pavlov. Cond. lever latency	1.9	2.6	6.6	-1.1	-2.6	-0.3
Pavlov. Cond. magazine entry latency	2.3	2.6	4.7	2.2	1.5	-0.9
Pavlov. Cond. change in total contacts	2.5	3.4	8.0	1.5	2.8	-0.3
Pavlov. Cond. index score	2.8	3.6	7.5	1.8	2.7	-0.2
Pavlov. Cond. latency score	2.6	3.2	7.1	1.6	2.7	-0.1
Pavlov. Cond. lever contacts	2.8	3.8	10.0	1.0	3.2	0.6
Pavlov. Cond. magazine entry number	1.6	1.9	3.7	-1.9	-1.4	0.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	-0.9	0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.3	7.2	1.7	2.7	-0.2
Pavlov. Cond. response bias	2.9	3.9	9.9	1.4	3.1	0.1
Time in closed arm before self-admin	1.3	1.5	2.3	-1.4	1.5	0.3
Time in closed arm after self-admin	0.2	0.2	0.5	-0.7	-0.4	0.2
Time in open arm before self-admin	0.9	1.0	1.9	0.9	-1.4	-0.5
Time in open arm after self-admin	1.8	2.0	4.6	2.1	-0.6	-1.0
Bone: periosteal estimation	3.0	6.2	13.2	-3.6	0.6	2.2
Bone: periosteal perimeter	1.4	2.3	5.3	-2.3	0.4	1.2
Bone: post-yield work	2.1	2.8	4.4	-1.9	0.7	2.1
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	-0.2	-0.6	-0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.3	-0.4	0.1
Progressive ratio test 1 inactive lever presses	2.1	2.3	3.0	1.4	1.3	-1.7
Progressive ratio test 2 active lever presses	0.2	0.3	0.8	-0.9	0.1	0.0
Progressive ratio test 2 breakpoint	0.4	0.4	1.2	-1.1	0.4	0.2
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	-0.1	0.5	-0.7
Incentive Sensitization - Responses	0.8	0.8	1.2	-1.0	1.1	0.1
Incentive Sensitization - Breakpoint	0.8	0.8	1.2	-1.0	1.1	0.1
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.0	0.0	-1.0	-0.6
Progressive ratio	0.2	0.2	0.5	-0.2	0.7	-0.1
Food seeking constrained by brief footshock	0.4	0.5	1.6	0.1	1.3	-0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.2	-0.1	0.0
Retroperitoneal fat weight	5.2	17.1	32.6	5.7	-0.1	-4.3
Reaction time number correct	0.5	0.8	2.3	-0.1	-1.5	-0.2
Reaction time mean minus median	1.0	1.3	2.4	-0.5	1.5	1.1
Reaction time mean minus median AUC	0.3	0.3	0.5	0.2	0.7	0.7
Reaction time num false alarms	2.4	3.2	7.0	-2.7	-1.6	0.5
Reaction time num false alarms AUC	2.7	3.7	7.3	-2.7	-1.7	0.9
Reaction time trials correct on left	0.5	0.8	2.3	-0.1	-1.5	-0.2
Reaction time trials on left	0.6	0.8	2.3	-0.1	-1.5	-0.2
Reaction time mean	0.3	0.4	1.0	0.5	1.0	-0.1
Reaction time mean AUC	0.5	0.6	1.1	0.8	1.0	-0.3
Median of all reaction times	0.2	0.3	0.5	0.6	0.7	-0.5
Reaction time omissions	0.1	0.1	0.3	-0.6	-0.1	0.3
Reaction time false alarm rate	1.0	1.5	3.3	-1.8	-0.9	0.6
Reaction time premature initiation rate	1.2	1.6	4.6	-0.1	2.1	0.5
Reaction time premature initiations	0.2	0.3	0.8	0.0	0.9	0.2
Std. dev. reaction times	1.1	1.6	3.7	0.1	1.9	1.0
Reaction time trials completed	0.6	0.8	2.3	-0.1	-1.5	-0.2
Reaction time trials AUC	0.7	1.0	2.8	-0.0	-1.7	-0.4
Run reversals in cocaine runway, females	1.1	1.0	1.5	-1.1	1.2	0.7
Run reversals in cocaine runway, males	3.0	3.0	5.7	2.4	-0.4	-1.7
Latency to leave start box in cocaine runway	4.7	5.1	9.8	-3.1	1.4	1.9
Latency to leave start box in cocaine runway, F	3.8	4.1	9.0	-3.0	0.8	1.6
Latency to leave start box in cocaine runway, M	1.2	1.1	1.6	-1.3	0.7	1.1
Std. dev. time between licks in bursts	2.5	3.0	5.6	-2.4	0.1	1.8
Total sessions with >9 infusions	0.0	0.0	0.1	-0.3	-0.1	-0.2
Short access day 1 total inactive lever presses	0.8	0.9	1.7	1.0	0.4	-1.3
Short access day 10 total inactive lever presses	1.5	1.6	2.7	1.6	0.5	-1.4
Short access day 1 total infusions	0.0	0.0	0.0	0.1	0.0	-0.0
Short access day 10 total infusions	0.1	0.2	0.5	-0.1	0.7	-0.1
Short access total infusions	0.1	0.1	0.3	-0.2	0.5	-0.1
Short access day 1 locomotion	0.6	0.6	1.0	-1.0	0.9	0.1
Short access day 10 total locomotion	1.2	1.3	2.4	-1.6	0.0	1.3
Short access total locomotion	1.7	1.8	4.0	-2.0	0.2	1.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.2	-0.3	-0.5
Compulsive drug intake	0.7	0.7	0.9	0.9	-0.5	-0.9
One hour access (shock baseline)	0.2	0.3	0.6	-0.8	0.3	0.4
Social response proportion	1.1	1.1	1.8	1.4	-1.2	-0.4
Social responses	1.0	1.2	2.3	-0.3	-1.5	1.1
Social time	3.0	4.0	6.8	-2.1	-0.8	2.6
Soleus weight	1.1	3.4	4.9	2.2	1.5	-1.7
Bone: stiffness	0.6	1.0	2.2	-1.5	-0.1	0.8
Tibialis anterior weight	0.5	1.7	3.6	1.9	0.7	-0.9
Time to tail flick, vehicle, before self-admin	0.8	0.8	1.7	0.9	-0.0	-1.3
Time to tail flick, vehicle, after self-admin	3.2	3.4	4.1	-1.9	1.5	2.0
Time to tail flick, test, before self-admin	4.4	4.3	6.2	-2.5	0.8	2.5
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.0	-0.5	-0.5
Delta time to tail flick, vehicle, before/after SA	6.2	6.1	10.2	-2.4	1.5	3.2
Delta time to tail flick, test, before/after SA	2.2	2.0	2.7	1.1	-1.4	-1.6
Tibia length	2.3	6.4	11.2	-2.8	0.4	3.4
Ambulatory time before self-admin	2.3	2.3	3.5	1.9	1.4	-1.2
Ambulatory time after self-admin	1.6	1.8	5.2	-0.1	2.3	0.2
Bone: tissue strength	0.6	0.6	1.7	0.3	0.1	1.3
Total heroin consumption	0.3	0.4	0.8	0.9	-0.3	-0.4
Bone: trabecular number	2.4	3.8	6.9	-2.6	-1.9	1.0
Bone: trabecular spacing	0.9	1.1	2.3	1.5	1.0	-0.3
Bone: trabecular thickness	0.3	0.3	0.9	-1.0	-0.1	-0.2
Bone: trabecular tissue density	0.8	1.1	1.6	-0.7	1.3	1.1
Water consumed over 24 hours	0.6	0.7	1.4	1.2	-0.6	-0.6
Number of responses in last shaping day	0.3	0.4	0.5	-0.7	-0.7	0.3