Hub : Genes

Creb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative TSS	NM_031017.2	0.31	0.18	6.0e-03	0	0.01	0	0	9.4e-02	1.2e-02	7.6e-02	9.9e-02
2	Brain	mRNA stability	Creb1	0.03	0.03	2.7e-03	0.01	0.01	0.01	0.01	3.8e-02	2.4e-02	3.5e-02	3.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.1	0.1	0.1	-0.2	0.4
Area under the delay curve	0.6	0.7	1.3	1.1	-0.3
BMI with tail	9.8	33.9	40.3	6.3	-5.2
BMI without tail	2.7	8.3	9.1	2.7	-3.0
Body weight	0.4	1.8	2.9	1.7	-0.9
Weight adjusted by age	0.5	0.8	1.4	0.5	1.2
Bone surface	0.2	0.4	0.7	-0.2	0.8
Bone volume	0.8	1.4	1.6	-1.1	1.2
Breakpoint value in progressive ratio session	2.8	3.3	3.5	-1.9	1.8
Number of licking bursts	0.1	0.2	0.3	-0.3	-0.5
Context. condit. distance diff. score	1.1	1.3	1.5	1.1	-1.2
Locomotion velocity, session 1	1.8	1.9	2.3	-1.5	1.2
Locomotion distance, session 1	0.1	0.2	0.2	-0.4	0.4
Locomotion velocity, session 2	0.2	0.2	0.2	0.5	0.4
Locomotion distance, session 2	0.0	0.0	0.1	0.2	-0.1
Locomotion velocity, session 3	1.8	2.1	3.4	1.9	-0.8
Locomotion distance, session 3	1.2	1.3	1.7	-0.9	1.3
Stereotopy head waving bouts, day 3	3.3	3.8	5.1	2.3	-1.6
Stereotopy head waving duration, day 3	3.9	4.6	6.5	2.6	-1.6
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	-0.1
Locomotion distance, session 7	0.4	0.6	0.8	-0.6	0.9
Stereotopy head waving bouts, day 7	0.4	0.4	0.5	0.7	-0.6
Stereotopy head waving duration, day 7	3.0	3.6	4.1	2.0	-1.8
Locomotion velocity, session 8	0.4	0.5	0.9	0.9	-0.3
Locomotion distance, session 8	0.3	0.5	0.5	0.7	-0.7
Degree of sensitization distance	0.2	0.2	0.2	0.3	-0.5
Degree of sensitization stereotypy	0.8	0.9	1.0	0.9	-1.0
Conditioned locomotion	1.2	1.4	1.7	-1.1	1.3
Cocaine response after cond. corrected	1.1	1.3	1.6	-1.0	1.3
Cocaine response after cond. not corrected	1.9	2.3	2.8	-1.7	1.3
Cocaine response before conditioning	0.4	0.4	0.8	-0.9	-0.3
Saline control response	0.9	1.2	2.2	1.5	-0.5
Bone: connectivity density	0.8	1.2	1.6	1.3	-0.9
Bone: cortical apparent density	2.2	3.0	4.3	2.1	-1.3
Bone: cortical area	0.5	0.8	1.2	-0.6	1.1
Bone: cortical porosity	9.6	10.4	13.0	-3.6	2.8
Bone: cortical porosity	11.1	12.0	14.7	-3.8	3.1
Bone: cortical thickness	0.1	0.2	0.4	-0.1	0.7
Bone: cortical thickness	1.2	1.4	1.9	-1.0	1.4
Bone: cortical tissue density	2.5	3.4	4.8	2.2	-1.4
Condit. Reinf. active minus inactive responses	1.5	1.6	2.0	-1.4	1.1
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.3	-1.2	0.2
Condit. Reinf. active responses	1.5	1.9	2.5	-1.1	1.6
Condit. Reinf. inactive responses	0.8	1.0	2.0	-0.0	1.4
Incentive salience index mean	1.3	1.6	2.0	-1.1	1.4
Condit. Reinf. lever presses	0.6	0.9	1.7	-0.2	1.3
Condit. Reinf. active minus inactive responses	8.0	10.3	10.6	-3.2	3.3
Condit. Reinf. active-inactive response ratio	7.5	8.6	9.7	-3.1	2.8
Condit. Reinf. active responses	5.1	7.1	8.0	-2.5	2.8
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.2	0.7
Condit. Reinf. lever presses	1.2	1.7	1.8	-1.3	1.4
Condit. Reinf. lever reinforcers received	5.6	7.7	8.2	-2.7	2.9
Conditioned reinforcement - actives	1.8	3.0	4.4	2.1	-1.3
Conditioned reinforcement - inactives	1.0	1.4	2.6	-0.5	1.6
Conditioned locomotion	12.8	16.6	27.4	5.2	-2.4
Patch foraging indifference point 0 sec	0.8	1.5	1.7	1.1	-1.3
Patch foraging indifference point AUC	0.8	1.2	2.3	-0.2	1.5
Delay disc. indifference point, 0s delay	2.4	2.6	3.7	1.9	-1.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.3	0.3
Delay disc. indifference point, 2s delay	3.2	3.5	5.2	2.3	-1.4
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	0.6	-0.4
Delay disc. indifference point, 4s delay	2.7	2.8	4.3	2.1	-1.1
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	0.7	0.1
Indifference point function ln k	1.7	3.0	4.1	1.4	-2.0
Indifference point function log k	1.7	3.0	4.1	1.4	-2.0
Patch foraging total patch changes 0 sec	0.7	1.3	1.6	1.0	-1.2
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	0.1	0.6
Patch foraging total patch changes 18 sec	0.1	0.2	0.3	0.3	-0.5
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	-0.3	0.5
Patch foraging total patch changes 6 sec	1.7	2.6	4.2	2.0	-1.0
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.6	0.0
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.0	-0.2
Patch foraging water rate 12 sec	0.3	0.7	1.0	-0.7	-1.0
Patch foraging water rate 18 sec	0.7	1.1	2.1	-1.4	0.3
Patch foraging water rate 24 sec	0.5	0.7	1.0	-1.0	-0.6
Patch foraging water rate 6 sec	1.0	1.4	2.9	0.2	-1.7
Seeking ratio, delayed vs. immediate footshock	2.2	2.7	4.3	-2.1	1.1
Distance traveled before self-admin	2.0	2.6	4.6	-0.7	2.1
Distance traveled after self-admin	0.1	0.1	0.1	0.2	0.3
Extensor digitorum longus weight	2.4	9.4	11.4	3.4	-2.7
Bone: elastic displacement	0.2	0.2	0.3	0.5	-0.3
Bone: elastic work	0.3	0.4	0.5	-0.7	0.6
Bone: endosteal estimation	1.4	3.1	3.8	-1.6	1.9
Bone: endosteal perimeter	0.5	1.1	1.6	-1.3	0.8
Epididymis fat weight	0.4	1.3	1.9	1.4	-0.8
Delta time in closed arm before/after self-admin	1.7	1.6	2.2	1.5	-1.0
Delta time in open arm before/after self-admin	4.9	4.8	5.9	-1.9	2.4
Diff in mean of infusions in LGA sessions	0.4	0.5	0.5	0.7	-0.7
Delay discount exponential model param	0.6	0.6	1.2	-1.1	0.3
Extinction: sum of active levers before priming	0.9	1.0	2.0	1.4	-0.0
Active lever presses in extinction session 6	1.5	1.5	2.0	-1.4	0.9
Bone: final force	1.5	2.4	2.5	-1.5	1.6
Bone: final moment	1.0	1.7	1.8	-1.4	1.2
Food consumed during 24 hour testing period	0.6	0.9	1.0	-0.9	1.0
Glucose	0.5	0.8	1.0	0.8	-1.0
Heart weight	0.3	0.5	0.8	-0.9	0.3
Delay discount hyperbolic model param	0.7	0.8	1.4	-1.2	0.4
Intermittent access intake day 1-15 change	0.3	0.5	0.6	0.8	-0.7
Intermittent access intake escalation	0.2	0.3	0.5	0.4	-0.7
Intermittent access intake escalation 2	0.4	0.5	0.7	0.8	-0.5
Intermitt. access day 1 inactive lever presses	0.2	0.6	0.8	-0.9	-0.6
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	-0.3	0.2
Intermitt. access escalation Index	1.3	1.9	3.6	1.9	-0.4
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.1	0.4
Intermittent access day 15 total infusions	0.6	0.9	1.0	1.0	-0.8
Intermittent access terminal intake (last 3 days)	1.5	1.9	2.1	1.4	-1.3
Intermittent access total infusions	0.8	0.9	1.6	1.3	-0.4
Intermittent access day 1 locomotion	0.6	0.7	1.4	1.2	-0.1
Intermittent access day 15 total locomotion	0.7	1.2	1.4	1.2	-1.0
Intermittent access total locomotion	4.9	5.9	9.2	3.0	-1.6
Intermittent access standard deviation	0.1	0.1	0.3	-0.5	0.2
Left kidney weight	0.9	4.0	5.7	2.4	-1.5
Right kidney weight	0.7	3.3	3.3	1.8	-1.8
Cocaine induced anxiety	0.2	0.3	0.4	0.3	-0.7
Post-drug Anxiety	0.8	0.8	1.4	0.5	-1.2
Baseline Anxiety	0.2	0.3	0.3	0.5	-0.5
Tail length	4.1	15.8	18.7	-4.3	3.6
Length with tail	3.4	14.7	17.1	-3.5	4.1
Length without tail	0.4	1.2	2.4	-0.3	1.6
Times rat made contact with spout	0.8	1.0	1.0	-1.0	1.0
Lifetime Intake	0.8	1.0	1.4	1.2	-0.8
Liver weight, left	2.3	3.7	5.3	-1.5	2.3
Liver weight, right	0.7	1.3	2.3	1.5	-0.5
Locomotor activity	0.0	0.0	0.0	-0.2	-0.2
Locomotor testing distance	0.1	0.2	0.3	-0.4	-0.5
Locomotor testing rearing	0.2	0.4	0.7	-0.8	-0.4
Locomotion in novel chamber	2.0	2.5	4.5	2.1	-0.7
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	0.1	0.1
Fecal boli incidents, locomotor time 1	1.6	2.4	3.3	-1.8	1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.1
Time >=10cm from walls, locomotor time 1	1.4	1.5	2.7	-0.5	1.7
Bouts of movement, locomotor time 1	1.7	1.9	2.1	-1.3	1.4
Total resting periods, locomotor time 1	1.1	1.3	1.4	-1.1	1.2
Rest time, locomotor task time 1	2.3	2.8	3.3	-1.5	1.8
Distance moved, locomotor task time 1	1.4	2.1	3.5	1.9	-0.8
Vertical activity count, locomotor time 1	0.9	2.1	2.8	1.7	-1.1
Time >=10cm from walls, locomotor time 2	0.9	1.3	1.7	-1.3	0.9
Bouts of movement, locomotor time 2	0.3	0.4	0.7	0.4	-0.8
Total resting periods, locomotor time 2	0.0	0.1	0.1	0.1	-0.3
Rest time, locomotor task time 2	0.9	1.1	2.1	-0.4	1.5
Distance moved, locomotor task time 2	1.3	1.5	2.0	1.4	-1.0
Vertical activity count, locomotor time 2	3.3	4.5	4.6	2.1	-2.2
Light reinforcement 1	1.5	3.8	4.8	2.2	-1.7
Light reinforcement 2	0.3	0.5	0.8	-0.4	0.9
Bone: marrow area	1.3	2.8	3.5	-1.5	1.9
Bone: maximum diameter	0.8	1.6	1.7	-1.2	1.3
Bone: maximum force	1.0	1.8	2.0	-1.4	1.3
Bone: maximum moment	0.6	1.0	1.4	-1.2	0.8
Mean time between licks in bursts	0.3	0.9	1.0	0.9	-1.0
Mean num. licks in bursts	0.2	0.3	0.6	-0.0	0.8
Cd content in liver	1.0	1.1	1.4	1.0	-1.2
Co content in liver	0.0	0.0	0.0	-0.2	-0.1
Cu content in liver	0.1	0.1	0.2	0.3	-0.4
Fe content in liver	1.1	1.3	2.5	-1.6	0.3
K content in liver	0.3	0.3	0.6	0.8	-0.1
Mg content in liver	0.3	0.3	0.4	0.6	-0.4
Mn content in liver	1.3	1.4	1.5	1.1	-1.2
Na content in liver	0.6	0.6	1.1	0.4	1.1
Rb content in liver	0.1	0.2	0.2	0.3	-0.5
Se content in liver	0.2	0.3	0.4	-0.4	-0.6
Sr content in liver	0.9	0.8	0.9	-0.8	1.0
Zn content in liver	0.3	0.3	0.4	0.7	-0.5
Bone: minimum diameter	1.7	3.1	3.4	-1.8	1.6
Time in familiar zone, hab. session 1	3.4	3.2	4.4	2.1	-1.4
Time in novel zone, hab. session 1	9.0	9.0	11.5	-3.4	2.5
Total zone transitions, hab. session 1	1.0	1.4	2.0	-1.4	1.0
Total locomotion distance, hab. session 1	3.6	5.1	7.3	-2.7	1.7
Locomotion velocity, hab. session 1	3.2	4.6	7.0	-2.6	1.5
Time in familiar zone, hab. session 2	0.5	0.5	0.9	0.9	-0.4
Time in novel zone, hab. session 2	0.5	0.5	0.9	-1.0	0.0
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.5	0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.8	-0.9	0.1
Locomotion velocity, hab. session 2	0.3	0.4	0.8	-0.9	0.1
Novel to familiar place preference ratio	1.6	1.8	2.0	-1.4	1.2
Novelty place preference	1.9	2.0	2.1	-1.4	1.4
Time in novel zone, NPP test	2.3	2.5	2.7	-1.6	1.5
Total zone transitions, NPP test	0.3	0.4	0.5	-0.7	0.6
Total locomotion distance, NPP test	1.0	1.4	1.9	-1.4	0.9
Locomotion velocity, NPP test	0.5	0.8	1.2	-1.1	0.6
Intraocular pressure	3.5	5.1	5.1	2.3	-2.2
Delta distance traveled before/after self-admin	1.2	1.2	2.1	0.6	-1.5
Delta ambulatory time before/after self-admin	1.2	1.5	2.5	0.7	-1.6
Parametrial fat weight	0.3	0.6	1.1	-1.0	-0.4
Pavlov. Cond. lever latency	0.1	0.2	0.2	0.4	-0.5
Pavlov. Cond. magazine entry latency	1.3	1.6	2.2	-1.5	1.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	-0.1
Pavlov. Cond. index score	0.6	0.8	0.8	-0.9	0.9
Pavlov. Cond. latency score	0.5	0.7	0.7	-0.8	0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.2	0.5
Pavlov. Cond. magazine entry number	0.4	0.6	0.9	0.9	-0.5
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	0.8	-0.9	0.9
Pavlov. Cond. response bias	0.7	0.9	1.0	-1.0	0.9
Pavlov. Cond. lever latency	1.8	2.5	3.3	1.8	-1.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.3	-0.3	0.6
Pavlov. Cond. change in total contacts	1.4	2.3	2.3	-1.5	1.5
Pavlov. Cond. index score	1.9	2.6	2.6	-1.6	1.6
Pavlov. Cond. latency score	1.7	2.3	2.3	-1.5	1.5
Pavlov. Cond. lever contacts	2.7	3.7	4.3	-2.1	1.7
Pavlov. Cond. magazine entry number	0.5	0.6	1.1	0.4	-1.0
Pavlov. Cond. intertrial magazine entries	1.8	2.8	2.8	1.7	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.2	2.3	-1.4	1.5
Pavlov. Cond. response bias	2.5	3.3	3.6	-1.9	1.8
Time in closed arm before self-admin	0.7	0.9	1.7	-0.1	1.3
Time in closed arm after self-admin	0.1	0.2	0.3	-0.5	0.0
Time in open arm before self-admin	1.8	2.0	2.7	1.1	-1.7
Time in open arm after self-admin	2.1	2.3	3.0	-1.3	1.7
Bone: periosteal estimation	1.5	3.2	3.5	-1.7	1.9
Bone: periosteal perimeter	1.1	1.9	1.9	-1.4	1.4
Bone: post-yield work	0.0	0.0	0.1	-0.2	-0.2
Progressive ratio test 1 active lever presses	0.3	0.4	0.8	0.9	-0.2
Progressive ratio test 1 breakpoint	0.3	0.4	0.8	0.9	-0.0
Progressive ratio test 1 inactive lever presses	1.3	1.9	1.9	1.4	-1.4
Progressive ratio test 2 active lever presses	0.7	0.8	1.6	1.2	0.1
Progressive ratio test 2 breakpoint	0.5	0.5	1.0	1.0	0.2
Progressive ratio test 2 inactive lever presses	1.4	2.2	4.3	2.1	-0.4
Incentive Sensitization - Responses	0.6	0.9	1.5	1.2	0.5
Incentive Sensitization - Breakpoint	0.7	0.9	1.6	1.3	0.4
Sum of active levers in priming session hrs 5-6	1.4	1.3	2.2	-0.7	1.5
Progressive ratio	0.3	0.4	0.8	-0.9	0.2
Food seeking constrained by brief footshock	2.2	2.7	3.6	1.9	-1.3
Seeking ratio, punishment vs. effort	1.9	2.7	4.7	2.2	-0.9
Retroperitoneal fat weight	1.0	4.2	4.9	2.2	-1.9
Reaction time number correct	0.4	0.7	0.8	0.8	-0.9
Reaction time mean minus median	0.0	0.0	0.0	-0.1	0.2
Reaction time mean minus median AUC	0.2	0.5	0.7	-0.8	0.5
Reaction time num false alarms	3.4	4.7	5.4	2.0	-2.3
Reaction time num false alarms AUC	2.7	4.3	5.1	1.9	-2.2
Reaction time trials correct on left	0.4	0.7	0.8	0.8	-0.9
Reaction time trials on left	0.4	0.8	0.9	0.8	-0.9
Reaction time mean	3.4	5.4	5.5	-2.3	2.4
Reaction time mean AUC	2.8	4.5	4.7	-2.2	2.1
Median of all reaction times	5.5	7.8	7.8	-2.8	2.8
Reaction time omissions	0.1	0.2	0.2	0.4	-0.4
Reaction time false alarm rate	1.1	1.6	2.3	0.9	-1.5
Reaction time premature initiation rate	0.1	0.2	0.3	-0.1	0.6
Reaction time premature initiations	0.1	0.1	0.3	0.5	-0.0
Std. dev. reaction times	0.7	1.3	1.6	-1.3	1.0
Reaction time trials completed	0.4	0.8	0.9	0.8	-0.9
Reaction time trials AUC	0.3	0.5	0.6	0.7	-0.8
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.4	-0.8
Run reversals in cocaine runway, males	1.5	1.5	2.8	-1.7	0.4
Latency to leave start box in cocaine runway	1.6	1.8	3.3	0.6	-1.8
Latency to leave start box in cocaine runway, F	1.7	1.9	3.1	0.9	-1.8
Latency to leave start box in cocaine runway, M	0.3	0.3	0.6	-0.1	-0.8
Std. dev. time between licks in bursts	2.0	2.7	3.7	1.3	-1.9
Total sessions with >9 infusions	0.0	0.0	0.1	-0.2	-0.2
Short access day 1 total inactive lever presses	1.2	1.6	2.7	1.6	-0.7
Short access day 10 total inactive lever presses	1.1	2.7	5.3	-2.3	0.2
Short access day 1 total infusions	0.2	0.2	0.4	0.2	-0.6
Short access day 10 total infusions	0.4	0.4	0.7	0.8	-0.4
Short access total infusions	1.1	1.4	1.4	1.2	-1.2
Short access day 1 locomotion	0.2	0.2	0.4	0.0	0.6
Short access day 10 total locomotion	0.9	1.7	2.9	1.7	-0.7
Short access total locomotion	3.0	3.6	6.1	2.5	-1.0
One hour access (0.3 mA shock)	0.4	0.5	0.9	1.0	-0.2
Compulsive drug intake	0.1	0.1	0.3	-0.1	-0.5
One hour access (shock baseline)	0.1	0.1	0.1	0.2	-0.3
Social response proportion	0.3	0.4	0.4	-0.6	0.6
Social responses	0.6	0.7	0.9	-0.8	1.0
Social time	0.2	0.3	0.4	-0.5	0.6
Soleus weight	0.3	0.8	1.6	1.3	-0.1
Bone: stiffness	0.9	1.5	1.6	-1.3	1.1
Tibialis anterior weight	0.7	2.5	3.9	2.0	-1.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.1	0.4
Time to tail flick, vehicle, after self-admin	4.1	5.4	10.3	-3.2	0.6
Time to tail flick, test, before self-admin	0.5	0.5	1.0	-1.0	0.3
Time to tail flick, test, after self-admin	5.5	5.7	9.0	3.0	-1.6
Delta time to tail flick, vehicle, before/after SA	1.8	1.7	3.4	-1.8	-0.3
Delta time to tail flick, test, before/after SA	6.7	6.9	12.2	3.5	-1.2
Tibia length	1.2	3.3	4.1	-1.6	2.0
Ambulatory time before self-admin	1.1	1.6	3.1	-0.3	1.8
Ambulatory time after self-admin	1.3	1.6	3.0	1.7	-0.4
Bone: tissue strength	0.4	0.4	0.7	0.3	-0.8
Total heroin consumption	2.0	2.4	3.9	-2.0	0.9
Bone: trabecular number	0.1	0.2	0.3	0.5	-0.5
Bone: trabecular spacing	0.4	0.5	0.5	-0.7	0.7
Bone: trabecular thickness	0.5	0.6	0.7	-0.8	0.8
Bone: trabecular tissue density	1.5	2.2	3.0	-1.7	1.1
Water consumed over 24 hours	0.0	0.0	0.0	0.1	0.0
Number of responses in last shaping day	1.5	1.6	2.8	-1.7	0.7