Hub : Genes

Creb1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative TSS NM_031017.2 0.31 0.18 6.0e-03 0 0.01 0 0 9.4e-02 1.2e-02 7.6e-02 9.5e-02
2 NAcc alternative TSS XM_006245070.4 0.04 0.05 8.4e-03 0.01 0.01 0 0.01 3.7e-02 3.9e-02 7.4e-02 2.6e-02
3 Brain mRNA stability Creb1 0.03 0.03 2.7e-03 0.01 0.01 0.01 0.01 3.8e-02 2.4e-02 3.5e-02 3.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.10.1-0.20.20.4
Area under the delay curve0.40.51.31.1-0.4-0.3
BMI with tail9.633.640.36.3-5.7-5.2
BMI without tail1.89.511.92.7-3.5-3.0
Body weight0.41.72.91.7-1.2-0.9
Weight adjusted by age0.20.61.40.50.51.2
Bone surface0.20.40.7-0.20.60.8
Bone volume0.71.41.6-1.11.21.2
Breakpoint value in progressive ratio session1.63.03.5-1.91.51.8
Number of licking bursts0.00.10.3-0.3-0.2-0.5
Context. condit. distance diff. score0.91.11.51.1-0.9-1.2
Locomotion velocity, session 11.71.92.3-1.51.41.2
Locomotion distance, session 10.10.20.2-0.40.40.4
Locomotion velocity, session 20.10.10.20.50.10.4
Locomotion distance, session 20.00.00.10.2-0.2-0.1
Locomotion velocity, session 31.51.73.41.9-1.0-0.8
Locomotion distance, session 31.21.41.7-0.91.31.3
Stereotopy head waving bouts, day 32.93.45.12.3-1.6-1.6
Stereotopy head waving duration, day 33.34.16.52.6-1.8-1.6
Locomotion velocity, session 70.00.00.00.2-0.2-0.1
Locomotion distance, session 70.40.50.8-0.60.60.9
Stereotopy head waving bouts, day 70.30.30.50.7-0.4-0.6
Stereotopy head waving duration, day 72.63.24.12.0-1.5-1.8
Locomotion velocity, session 80.30.40.90.9-0.3-0.3
Locomotion distance, session 80.20.40.50.7-0.4-0.7
Degree of sensitization distance0.20.20.40.3-0.6-0.5
Degree of sensitization stereotypy0.70.81.00.9-0.8-1.0
Conditioned locomotion1.21.51.7-1.11.21.3
Cocaine response after cond. corrected0.91.31.6-1.01.11.3
Cocaine response after cond. not corrected1.52.22.8-1.71.41.3
Cocaine response before conditioning0.20.30.8-0.90.1-0.3
Saline control response0.81.02.21.5-0.8-0.5
Bone: connectivity density0.71.21.61.3-1.1-0.9
Bone: cortical apparent density1.82.84.32.1-1.5-1.3
Bone: cortical area0.50.91.2-0.61.11.1
Bone: cortical porosity9.09.713.0-3.62.92.8
Bone: cortical porosity10.411.414.7-3.83.23.1
Bone: cortical thickness0.20.30.4-0.10.60.7
Bone: cortical thickness1.11.41.9-1.01.11.4
Bone: cortical tissue density2.03.24.82.2-1.6-1.4
Condit. Reinf. active minus inactive responses1.41.62.0-1.41.31.1
Condit. Reinf. active-inactive response ratio0.50.51.3-1.20.50.2
Condit. Reinf. active responses1.62.12.5-1.11.61.6
Condit. Reinf. inactive responses0.81.12.0-0.01.11.4
Incentive salience index mean1.31.72.0-1.11.41.4
Condit. Reinf. lever presses0.61.01.7-0.21.11.3
Condit. Reinf. active minus inactive responses6.610.210.6-3.23.23.3
Condit. Reinf. active-inactive response ratio5.28.39.7-3.12.82.8
Condit. Reinf. active responses4.97.08.0-2.52.62.8
Condit. Reinf. inactive responses0.20.20.4-0.20.40.7
Condit. Reinf. lever presses1.11.71.8-1.31.31.4
Condit. Reinf. lever reinforcers received5.47.68.2-2.72.72.9
Conditioned reinforcement - actives0.72.94.42.1-1.7-1.3
Conditioned reinforcement - inactives0.51.52.6-0.51.31.6
Conditioned locomotion10.115.027.45.2-3.4-2.4
Patch foraging indifference point 0 sec0.51.41.71.1-1.1-1.3
Patch foraging indifference point AUC0.51.12.3-0.21.01.5
Delay disc. indifference point, 0s delay2.12.43.71.9-1.4-1.3
Delay disc. indifference point, 16s delay0.00.10.1-0.30.20.3
Delay disc. indifference point, 2s delay2.83.15.22.3-1.5-1.4
Delay disc. indifference point, 24s delay0.10.20.30.6-0.5-0.4
Delay disc. indifference point, 4s delay2.32.44.32.1-1.3-1.1
Delay disc. indifference point, 8s delay0.10.20.50.70.00.1
Indifference point function ln k1.02.94.11.4-1.6-2.0
Indifference point function log k1.02.94.11.4-1.6-2.0
Patch foraging total patch changes 0 sec0.41.21.61.0-1.0-1.2
Patch foraging total patch changes 12 sec0.10.10.40.10.20.6
Patch foraging total patch changes 18 sec0.10.30.50.3-0.7-0.5
Patch foraging total patch changes 24 sec0.00.10.2-0.30.10.5
Patch foraging total patch changes 6 sec1.32.24.22.0-1.2-1.0
Patch foraging time to switch 0 sec0.00.10.3-0.60.20.0
Patch foraging water rate 0 sec0.00.00.10.0-0.3-0.2
Patch foraging water rate 12 sec0.20.61.0-0.7-0.6-1.0
Patch foraging water rate 18 sec0.40.92.1-1.40.70.3
Patch foraging water rate 24 sec0.30.41.0-1.0-0.0-0.6
Patch foraging water rate 6 sec1.21.72.90.2-1.5-1.7
Seeking ratio, delayed vs. immediate footshock1.42.04.3-2.10.71.1
Distance traveled before self-admin1.22.64.6-0.71.62.1
Distance traveled after self-admin0.00.00.10.20.00.3
Extensor digitorum longus weight2.39.111.43.4-2.9-2.7
Bone: elastic displacement0.10.10.30.5-0.2-0.3
Bone: elastic work0.30.40.5-0.70.70.6
Bone: endosteal estimation1.23.03.8-1.61.71.9
Bone: endosteal perimeter0.41.01.6-1.31.00.8
Epididymis fat weight0.21.11.91.4-0.8-0.8
Delta time in closed arm before/after self-admin1.61.52.21.5-1.1-1.0
Delta time in open arm before/after self-admin4.45.25.9-1.92.42.4
Diff in mean of infusions in LGA sessions0.30.50.50.7-0.7-0.7
Delay discount exponential model param0.40.51.2-1.10.40.3
Extinction: sum of active levers before priming0.50.72.01.4-0.4-0.0
Active lever presses in extinction session 61.21.22.0-1.40.90.9
Bone: final force1.52.42.5-1.51.61.6
Bone: final moment1.01.71.8-1.41.31.2
Food consumed during 24 hour testing period0.40.81.0-0.90.91.0
Glucose0.50.81.00.8-1.0-1.0
Heart weight0.30.50.8-0.90.80.3
Delay discount hyperbolic model param0.50.61.4-1.20.50.4
Intermittent access intake day 1-15 change0.10.40.60.8-0.4-0.7
Intermittent access intake escalation0.00.20.50.4-0.1-0.7
Intermittent access intake escalation 20.20.30.70.8-0.2-0.5
Intermitt. access day 1 inactive lever presses0.00.40.8-0.9-0.2-0.6
Intermitt. access day 15 inactive lever presses0.00.10.3-0.30.50.2
Intermitt. access escalation Index0.51.43.61.9-0.7-0.4
Intermittent access day 1 total infusions0.00.10.2-0.1-0.10.4
Intermittent access day 15 total infusions0.40.91.01.0-1.0-0.8
Intermittent access terminal intake (last 3 days)1.12.02.11.4-1.5-1.3
Intermittent access total infusions0.80.91.61.3-1.0-0.4
Intermittent access day 1 locomotion0.40.71.41.2-0.8-0.1
Intermittent access day 15 total locomotion0.41.52.21.2-1.5-1.0
Intermittent access total locomotion5.16.19.23.0-2.6-1.6
Intermittent access standard deviation0.00.20.3-0.50.50.2
Left kidney weight0.53.75.72.4-1.8-1.5
Right kidney weight0.53.64.21.8-2.0-1.8
Cocaine induced anxiety0.10.20.40.3-0.4-0.7
Post-drug Anxiety0.70.81.40.5-0.8-1.2
Baseline Anxiety0.10.20.30.5-0.4-0.5
Tail length2.714.718.7-4.33.53.6
Length with tail3.515.417.1-3.54.14.1
Length without tail0.31.72.7-0.31.61.6
Times rat made contact with spout0.91.01.1-1.01.01.0
Lifetime Intake0.91.11.41.2-1.1-0.8
Liver weight, left2.03.55.3-1.51.82.3
Liver weight, right0.61.12.31.5-0.8-0.5
Locomotor activity0.00.00.0-0.20.0-0.2
Locomotor testing distance0.10.20.3-0.4-0.1-0.5
Locomotor testing rearing0.10.30.7-0.80.0-0.4
Locomotion in novel chamber1.82.44.52.1-1.5-0.7
Locomotion in novel chamber post-restriction0.00.00.00.1-0.20.1
Fecal boli incidents, locomotor time 10.82.13.3-1.81.31.2
Change in fecal boli incidents, locomotor task0.10.10.20.40.10.1
Time >=10cm from walls, locomotor time 11.51.82.7-0.51.61.7
Bouts of movement, locomotor time 11.52.02.1-1.31.41.4
Total resting periods, locomotor time 11.11.31.4-1.11.21.2
Rest time, locomotor task time 11.83.03.3-1.51.81.8
Distance moved, locomotor task time 10.61.73.51.9-0.9-0.8
Vertical activity count, locomotor time 10.31.92.81.7-1.2-1.1
Time >=10cm from walls, locomotor time 20.41.21.7-1.31.00.9
Bouts of movement, locomotor time 20.10.50.70.4-0.8-0.8
Total resting periods, locomotor time 20.00.10.10.1-0.3-0.3
Rest time, locomotor task time 20.81.42.1-0.41.41.5
Distance moved, locomotor task time 21.11.42.01.4-1.1-1.0
Vertical activity count, locomotor time 22.04.74.92.1-2.2-2.2
Light reinforcement 10.83.54.82.2-1.7-1.7
Light reinforcement 20.30.71.0-0.41.00.9
Bone: marrow area1.12.73.5-1.51.61.9
Bone: maximum diameter0.81.61.7-1.21.31.3
Bone: maximum force0.91.72.0-1.41.31.3
Bone: maximum moment0.50.91.4-1.20.80.8
Mean time between licks in bursts0.21.01.10.9-1.1-1.0
Mean num. licks in bursts0.10.30.6-0.00.60.8
Cd content in liver0.80.91.41.0-0.7-1.2
Co content in liver0.00.00.1-0.20.3-0.1
Cu content in liver0.10.10.20.3-0.5-0.4
Fe content in liver0.81.02.5-1.60.60.3
K content in liver0.30.30.60.8-0.5-0.1
Mg content in liver0.40.40.70.6-0.8-0.4
Mn content in liver1.31.51.71.1-1.3-1.2
Na content in liver0.40.51.10.40.31.1
Rb content in liver0.20.20.30.3-0.5-0.5
Se content in liver0.30.30.4-0.4-0.6-0.6
Sr content in liver1.11.01.3-0.81.11.0
Zn content in liver0.30.40.50.7-0.7-0.5
Bone: minimum diameter1.63.13.4-1.81.81.6
Time in familiar zone, hab. session 12.62.94.42.1-1.4-1.4
Time in novel zone, hab. session 17.58.411.5-3.42.72.5
Total zone transitions, hab. session 11.01.32.0-1.41.11.0
Total locomotion distance, hab. session 13.24.67.3-2.71.91.7
Locomotion velocity, hab. session 12.84.07.0-2.61.61.5
Time in familiar zone, hab. session 20.40.50.90.9-0.6-0.4
Time in novel zone, hab. session 20.30.40.9-1.00.40.0
Total zone transitions, hab. session 20.10.20.3-0.50.50.1
Total locomotion distance, hab. session 20.30.40.8-0.90.50.1
Locomotion velocity, hab. session 20.30.30.8-0.90.50.1
Novel to familiar place preference ratio1.31.72.0-1.41.21.2
Novelty place preference1.51.92.1-1.41.31.4
Time in novel zone, NPP test1.92.32.7-1.61.41.5
Total zone transitions, NPP test0.30.40.5-0.70.70.6
Total locomotion distance, NPP test0.91.31.9-1.41.00.9
Locomotion velocity, NPP test0.50.71.2-1.10.70.6
Intraocular pressure3.05.05.12.3-2.2-2.2
Delta distance traveled before/after self-admin1.21.32.10.6-1.2-1.5
Delta ambulatory time before/after self-admin0.91.62.50.7-1.3-1.6
Parametrial fat weight0.20.41.1-1.00.1-0.4
Pavlov. Cond. lever latency0.10.10.20.4-0.3-0.5
Pavlov. Cond. magazine entry latency1.21.52.2-1.51.21.1
Pavlov. Cond. change in total contacts0.10.10.20.4-0.2-0.1
Pavlov. Cond. index score0.60.70.8-0.90.80.9
Pavlov. Cond. latency score0.50.60.7-0.80.70.9
Pavlov. Cond. lever contacts0.10.10.2-0.20.30.5
Pavlov. Cond. magazine entry number0.40.50.90.9-0.5-0.5
Pavlov. Cond. intertrial magazine entries0.00.00.00.2-0.10.0
Pavlov. Cond. lever-magazine prob. diff.0.60.70.8-0.90.80.9
Pavlov. Cond. response bias0.70.81.0-1.00.90.9
Pavlov. Cond. lever latency1.72.33.31.8-1.4-1.3
Pavlov. Cond. magazine entry latency0.20.20.3-0.30.50.6
Pavlov. Cond. change in total contacts0.92.32.3-1.51.51.5
Pavlov. Cond. index score1.62.62.6-1.61.61.6
Pavlov. Cond. latency score1.42.22.3-1.51.51.5
Pavlov. Cond. lever contacts2.43.54.3-2.11.81.7
Pavlov. Cond. magazine entry number0.50.71.10.4-0.9-1.0
Pavlov. Cond. intertrial magazine entries1.32.93.11.7-1.7-1.7
Pavlov. Cond. lever-magazine prob. diff.1.42.22.3-1.41.51.5
Pavlov. Cond. response bias2.43.33.6-1.91.81.8
Time in closed arm before self-admin0.71.21.8-0.11.31.3
Time in closed arm after self-admin0.10.10.3-0.50.20.0
Time in open arm before self-admin1.92.32.91.1-1.7-1.7
Time in open arm after self-admin2.02.23.0-1.31.41.7
Bone: periosteal estimation1.33.13.5-1.71.71.9
Bone: periosteal perimeter1.01.92.1-1.41.41.4
Bone: post-yield work0.00.00.1-0.2-0.1-0.2
Progressive ratio test 1 active lever presses0.20.40.80.9-0.6-0.2
Progressive ratio test 1 breakpoint0.20.40.80.9-0.5-0.0
Progressive ratio test 1 inactive lever presses0.92.33.01.4-1.7-1.4
Progressive ratio test 2 active lever presses0.40.61.61.2-0.50.1
Progressive ratio test 2 breakpoint0.30.41.01.0-0.30.2
Progressive ratio test 2 inactive lever presses0.61.94.32.1-1.1-0.4
Incentive Sensitization - Responses0.20.61.51.2-0.00.5
Incentive Sensitization - Breakpoint0.30.61.61.3-0.00.4
Sum of active levers in priming session hrs 5-61.41.32.2-0.71.21.5
Progressive ratio0.10.30.8-0.90.30.2
Food seeking constrained by brief footshock2.22.83.61.9-1.7-1.3
Seeking ratio, punishment vs. effort1.02.24.72.2-1.1-0.9
Retroperitoneal fat weight0.83.64.92.2-1.6-1.9
Reaction time number correct0.20.60.80.8-0.6-0.9
Reaction time mean minus median0.00.00.1-0.1-0.30.2
Reaction time mean minus median AUC0.00.30.7-0.80.20.5
Reaction time num false alarms2.95.05.42.0-2.3-2.3
Reaction time num false alarms AUC2.04.55.11.9-2.2-2.2
Reaction time trials correct on left0.20.60.80.8-0.6-0.9
Reaction time trials on left0.20.60.90.8-0.6-0.9
Reaction time mean2.24.95.5-2.32.02.4
Reaction time mean AUC1.63.94.7-2.21.72.1
Median of all reaction times4.77.37.8-2.82.52.8
Reaction time omissions0.10.20.20.4-0.5-0.4
Reaction time false alarm rate1.31.82.30.9-1.5-1.5
Reaction time premature initiation rate0.10.20.3-0.10.60.6
Reaction time premature initiations0.00.10.30.50.1-0.0
Std. dev. reaction times0.31.01.6-1.30.51.0
Reaction time trials completed0.20.60.90.8-0.6-0.9
Reaction time trials AUC0.10.40.60.7-0.5-0.8
Run reversals in cocaine runway, females0.20.30.60.4-0.2-0.8
Run reversals in cocaine runway, males1.01.12.8-1.70.70.4
Latency to leave start box in cocaine runway1.72.43.40.6-1.9-1.8
Latency to leave start box in cocaine runway, F1.72.13.10.9-1.6-1.8
Latency to leave start box in cocaine runway, M0.60.61.1-0.1-1.1-0.8
Std. dev. time between licks in bursts1.63.13.91.3-2.0-1.9
Total sessions with >9 infusions0.00.00.1-0.2-0.2-0.2
Short access day 1 total inactive lever presses0.71.42.71.6-1.0-0.7
Short access day 10 total inactive lever presses0.32.05.3-2.30.90.2
Short access day 1 total infusions0.10.30.40.2-0.6-0.6
Short access day 10 total infusions0.30.50.70.8-0.8-0.4
Short access total infusions0.91.31.41.2-1.1-1.2
Short access day 1 locomotion0.10.20.40.00.50.6
Short access day 10 total locomotion0.41.52.91.7-1.0-0.7
Short access total locomotion2.03.06.12.5-1.4-1.0
One hour access (0.3 mA shock)0.40.50.91.0-0.7-0.2
Compulsive drug intake0.10.10.3-0.10.2-0.5
One hour access (shock baseline)0.10.30.70.2-0.8-0.3
Social response proportion0.30.30.4-0.60.40.6
Social responses0.60.70.9-0.80.81.0
Social time0.20.30.4-0.50.50.6
Soleus weight0.20.61.61.3-0.5-0.1
Bone: stiffness0.71.31.6-1.31.01.1
Tibialis anterior weight0.62.23.92.0-1.3-1.0
Time to tail flick, vehicle, before self-admin0.10.10.20.10.10.4
Time to tail flick, vehicle, after self-admin2.04.110.3-3.21.30.6
Time to tail flick, test, before self-admin0.50.51.0-1.00.70.3
Time to tail flick, test, after self-admin4.85.19.03.0-1.9-1.6
Delta time to tail flick, vehicle, before/after SA1.11.23.4-1.80.3-0.3
Delta time to tail flick, test, before/after SA4.75.812.23.5-1.9-1.2
Tibia length1.33.54.1-1.61.92.0
Ambulatory time before self-admin0.51.53.1-0.31.11.8
Ambulatory time after self-admin0.81.33.01.7-0.8-0.4
Bone: tissue strength0.40.40.70.3-0.6-0.8
Total heroin consumption1.72.03.9-2.01.10.9
Bone: trabecular number0.10.30.40.5-0.6-0.5
Bone: trabecular spacing0.40.60.7-0.70.90.7
Bone: trabecular thickness0.40.60.7-0.80.80.8
Bone: trabecular tissue density1.12.03.0-1.71.31.1
Water consumed over 24 hours0.00.00.00.10.00.0
Number of responses in last shaping day0.91.22.8-1.70.70.7