Hub : Genes

Cradd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Cradd 0.04 0.02 9.2e-03 0 -0 -0 -0 1.4e-01 4.2e-01 8.8e-01 7.5e-01
2 pVTA intron excision ratio chr7_29937319_29938544 0.19 0.08 2.9e-04 0.15 0.09 0.12 0.13 5.6e-07 1.1e-04 5.4e-06 2.2e-06
3 Brain intron excision ratio chr7_29937319_29938544 0.1 0.05 5.5e-06 0.07 0.05 0.05 0.05 4.6e-07 1.3e-05 1.5e-05 9.0e-06
4 PL gene expression Cradd 0.12 0.06 8.1e-06 0.06 0.04 0.03 0.04 6.9e-07 7.0e-05 2.8e-04 1.1e-05
5 NAcc intron excision ratio chr7_29937319_29938544 0.12 0.06 5.2e-07 0.07 0.06 0.07 0.05 2.3e-08 2.5e-07 1.2e-08 1.7e-06
6 Liver gene expression Cradd 0.18 0.06 1.6e-11 0.1 0.08 0.07 0.1 5.9e-11 1.4e-09 9.9e-09 1.2e-10
7 NAcc gene expression Cradd 0.08 0.04 4.9e-03 0.01 0 -0 -0 2.2e-02 2.1e-01 4.6e-01 4.5e-01
8 Liver intron excision ratio chr7_29937319_29938544 0.11 0.05 7.0e-06 0.03 0.03 0.04 0.03 9.2e-05 7.1e-04 6.5e-05 4.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.10.20.80.30.1-0.20.90.4-0.60.60.2
Area under the delay curve1.71.82.91.4-1.7-1.5-1.1-1.21.2-1.0-1.5
BMI with tail2.99.315.00.6-2.8-2.1-3.8-3.23.9-3.8-2.8
BMI without tail0.91.82.9-1.4-1.2-0.7-1.7-0.91.7-1.7-1.0
Body weight2.29.119.9-4.5-2.6-2.6-3.1-1.63.4-3.4-2.1
Weight adjusted by age1.11.31.80.3-1.3-1.3-1.3-1.11.3-1.2-0.9
Bone surface0.10.20.60.3-0.3-0.8-0.2-0.30.5-0.5-0.6
Bone volume0.10.20.60.3-0.4-0.8-0.2-0.40.5-0.5-0.7
Breakpoint value in progressive ratio session0.60.61.71.3-0.7-0.4-1.2-0.70.4-0.4-0.6
Number of licking bursts1.11.31.81.0-1.0-1.2-1.0-1.31.2-1.3-1.1
Context. condit. distance diff. score0.60.71.1-0.80.80.81.00.9-0.70.70.6
Locomotion velocity, session 10.50.51.61.3-0.7-0.5-0.8-0.80.5-0.5-0.5
Locomotion distance, session 10.91.12.41.2-1.6-1.2-1.2-1.10.6-0.5-0.8
Locomotion velocity, session 22.52.94.0-1.61.31.51.51.9-1.91.92.0
Locomotion distance, session 21.01.33.10.5-1.8-1.6-1.5-1.00.8-0.7-0.7
Locomotion velocity, session 31.82.13.1-1.20.91.11.31.7-1.71.81.6
Locomotion distance, session 30.20.30.9-0.0-0.8-1.0-0.5-0.20.4-0.3-0.2
Stereotopy head waving bouts, day 31.82.13.5-0.21.01.01.91.6-1.81.81.4
Stereotopy head waving duration, day 31.72.12.9-0.71.21.51.61.5-1.71.71.3
Locomotion velocity, session 70.20.30.70.3-0.8-0.7-0.8-0.20.1-0.00.2
Locomotion distance, session 70.10.20.70.2-0.8-0.5-0.6-0.20.00.00.1
Stereotopy head waving bouts, day 70.30.30.6-0.30.3-0.00.50.7-0.70.60.8
Stereotopy head waving duration, day 70.00.00.10.2-0.0-0.3-0.2-0.00.1-0.1-0.0
Locomotion velocity, session 81.31.54.1-2.01.41.20.71.3-1.01.00.9
Locomotion distance, session 80.40.62.0-0.2-1.4-1.2-0.7-0.40.5-0.5-0.5
Degree of sensitization distance0.10.10.5-0.10.30.7-0.10.2-0.20.10.1
Degree of sensitization stereotypy0.30.30.6-0.40.60.30.40.6-0.60.50.8
Conditioned locomotion0.60.71.2-0.70.70.60.70.8-1.11.11.0
Cocaine response after cond. corrected0.10.10.6-0.80.40.10.30.20.2-0.2-0.3
Cocaine response after cond. not corrected0.10.10.4-0.50.1-0.10.0-0.10.5-0.5-0.6
Cocaine response before conditioning0.30.40.60.7-0.5-0.3-0.6-0.80.6-0.6-0.7
Saline control response0.10.10.5-0.7-0.10.20.40.1-0.20.20.1
Bone: connectivity density0.91.42.9-0.21.20.71.71.2-1.41.41.0
Bone: cortical apparent density0.10.10.3-0.6-0.3-0.20.00.1-0.10.00.4
Bone: cortical area1.32.03.50.8-1.6-1.4-1.1-1.31.5-1.4-1.9
Bone: cortical porosity1.11.22.5-1.61.21.00.61.2-1.11.20.7
Bone: cortical porosity0.10.20.8-0.90.30.1-0.30.4-0.20.3-0.1
Bone: cortical thickness0.30.41.30.1-0.8-0.6-0.4-0.50.5-0.5-1.1
Bone: cortical thickness0.00.00.2-0.00.10.4-0.10.0-0.20.2-0.2
Bone: cortical tissue density0.10.10.5-0.7-0.1-0.10.10.2-0.20.10.6
Condit. Reinf. active minus inactive responses2.83.27.12.7-1.6-1.4-1.9-2.01.5-1.5-1.3
Condit. Reinf. active-inactive response ratio3.13.46.82.6-1.6-1.5-1.6-2.11.7-1.7-1.7
Condit. Reinf. active responses2.12.66.82.6-1.3-0.9-1.7-1.81.4-1.3-1.3
Condit. Reinf. inactive responses0.10.10.30.50.20.5-0.5-0.1-0.10.10.1
Incentive salience index mean4.85.89.93.2-2.6-2.2-2.2-2.72.1-2.1-2.0
Condit. Reinf. lever presses2.43.25.52.2-2.3-1.8-1.5-2.01.4-1.4-1.5
Condit. Reinf. active minus inactive responses0.60.81.60.9-0.9-1.2-1.3-1.00.5-0.5-0.5
Condit. Reinf. active-inactive response ratio0.10.10.30.1-0.1-0.6-0.2-0.4-0.10.0-0.2
Condit. Reinf. active responses0.81.12.70.8-0.8-1.2-1.6-1.10.9-0.9-0.5
Condit. Reinf. inactive responses0.40.52.10.5-0.2-0.1-1.5-0.50.8-0.8-0.1
Condit. Reinf. lever presses0.10.20.8-0.2-0.5-0.5-0.9-0.3-0.10.10.2
Condit. Reinf. lever reinforcers received0.91.33.21.0-1.0-1.3-1.8-1.20.9-1.0-0.5
Conditioned reinforcement - actives0.20.20.5-0.3-0.7-0.7-0.3-0.50.5-0.2-0.3
Conditioned reinforcement - inactives0.10.20.5-0.7-0.3-0.70.20.2-0.20.20.1
Conditioned locomotion0.20.21.0-1.0-0.2-0.10.10.4-0.20.30.3
Patch foraging indifference point 0 sec0.20.30.8-0.70.1-0.00.90.7-0.60.40.6
Patch foraging indifference point AUC0.20.20.7-0.0-0.10.10.80.6-0.50.50.2
Delay disc. indifference point, 0s delay1.01.11.90.1-1.4-1.3-1.0-1.11.0-1.0-1.0
Delay disc. indifference point, 16s delay1.81.82.51.4-1.6-1.3-1.3-1.21.2-1.1-1.5
Delay disc. indifference point, 2s delay0.91.01.70.4-1.3-1.2-0.9-1.11.1-1.0-0.9
Delay disc. indifference point, 24s delay0.30.30.5-0.10.60.30.50.7-0.50.70.1
Delay disc. indifference point, 4s delay0.50.61.00.4-0.9-0.6-0.8-0.80.7-0.6-1.0
Delay disc. indifference point, 8s delay0.30.30.70.8-0.8-0.6-0.3-0.40.5-0.3-0.8
Indifference point function ln k0.10.10.3-0.40.30.1-0.6-0.10.3-0.40.1
Indifference point function log k0.10.10.3-0.40.30.1-0.6-0.10.3-0.40.1
Patch foraging total patch changes 0 sec0.20.30.6-0.80.0-0.00.70.7-0.50.40.6
Patch foraging total patch changes 12 sec0.91.22.81.0-1.7-1.2-0.5-0.91.0-1.0-1.0
Patch foraging total patch changes 18 sec0.30.41.5-0.6-0.3-0.11.20.6-0.50.40.5
Patch foraging total patch changes 24 sec0.10.10.5-0.7-0.3-0.30.30.30.1-0.10.1
Patch foraging total patch changes 6 sec0.00.00.1-0.00.00.10.30.00.0-0.1-0.0
Patch foraging time to switch 0 sec0.10.10.20.4-0.10.40.50.1-0.30.40.1
Patch foraging water rate 0 sec3.25.17.90.8-2.3-2.6-2.2-2.12.6-2.8-2.0
Patch foraging water rate 12 sec0.10.20.3-0.6-0.2-0.50.2-0.40.5-0.5-0.3
Patch foraging water rate 18 sec0.30.51.1-0.2-0.1-0.6-1.0-0.80.9-0.9-0.4
Patch foraging water rate 24 sec1.92.75.0-0.0-1.6-2.2-1.6-1.51.8-1.9-1.3
Patch foraging water rate 6 sec2.33.35.6-0.2-1.7-2.4-1.8-1.72.1-2.3-1.3
Seeking ratio, delayed vs. immediate footshock0.10.20.40.50.1-0.20.40.4-0.60.6-0.1
Distance traveled before self-admin0.60.71.01.0-0.6-0.9-0.7-1.00.8-0.8-0.8
Distance traveled after self-admin1.01.21.90.8-1.2-1.4-1.0-1.01.0-1.1-0.9
Extensor digitorum longus weight0.00.21.0-1.00.30.2-0.30.10.2-0.2-0.3
Bone: elastic displacement0.60.62.50.21.31.60.10.4-0.60.6-0.1
Bone: elastic work1.01.33.7-0.51.71.90.71.0-1.11.10.4
Bone: endosteal estimation0.20.30.70.8-0.5-0.5-0.2-0.50.9-0.8-0.3
Bone: endosteal perimeter1.53.04.81.1-1.7-1.8-1.2-1.72.2-2.1-1.8
Epididymis fat weight0.92.03.30.1-1.7-1.8-1.0-1.61.7-1.6-1.0
Delta time in closed arm before/after self-admin1.11.11.51.1-0.6-0.8-1.2-1.11.2-1.1-0.9
Delta time in open arm before/after self-admin0.50.51.0-0.30.40.50.90.6-1.00.80.6
Diff in mean of infusions in LGA sessions0.50.61.71.0-0.7-0.4-1.3-0.60.5-0.5-0.6
Delay discount exponential model param1.01.01.6-1.11.31.10.80.9-0.80.71.2
Extinction: sum of active levers before priming0.10.10.30.6-0.3-0.0-0.4-0.20.1-0.0-0.1
Active lever presses in extinction session 62.42.33.41.8-1.4-1.8-1.3-1.51.4-1.5-1.3
Bone: final force0.71.11.71.1-1.3-1.2-0.4-0.90.8-0.8-1.3
Bone: final moment0.91.52.51.3-1.4-1.4-0.6-1.11.0-1.0-1.6
Food consumed during 24 hour testing period0.60.72.7-1.61.10.90.30.6-0.20.20.7
Glucose0.10.10.30.5-0.5-0.2-0.3-0.30.2-0.2-0.2
Heart weight1.52.14.40.6-1.5-2.1-1.7-1.21.5-1.4-1.2
Delay discount hyperbolic model param1.11.21.9-1.01.41.20.91.0-1.00.81.3
Intermittent access intake day 1-15 change1.51.42.10.1-1.2-1.4-1.2-1.41.3-1.3-1.2
Intermittent access intake escalation2.02.02.50.6-1.5-1.6-1.4-1.61.6-1.5-1.3
Intermittent access intake escalation 20.80.81.20.5-1.0-1.0-0.8-0.91.1-0.9-0.8
Intermitt. access day 1 inactive lever presses0.60.61.2-0.11.10.40.30.9-1.01.00.9
Intermitt. access day 15 inactive lever presses0.20.20.3-0.60.60.1-0.10.5-0.50.40.6
Intermitt. access escalation Index0.10.10.50.70.40.2-0.30.0-0.20.20.2
Intermittent access day 1 total infusions0.70.83.6-1.90.60.70.60.8-0.30.40.7
Intermittent access day 15 total infusions0.30.32.2-1.5-0.1-0.30.1-0.00.4-0.40.1
Intermittent access terminal intake (last 3 days)0.40.52.1-1.4-0.4-0.5-0.4-0.30.7-0.7-0.2
Intermittent access total infusions0.40.52.4-1.5-0.5-0.4-0.3-0.20.7-0.7-0.2
Intermittent access day 1 locomotion2.52.65.6-2.41.41.21.71.8-1.41.31.5
Intermittent access day 15 total locomotion3.03.29.5-3.11.11.11.71.9-1.41.51.6
Intermittent access total locomotion2.52.88.8-3.01.01.31.51.7-1.31.31.5
Intermittent access standard deviation0.90.91.5-0.1-1.1-1.2-0.5-0.91.2-1.0-1.0
Left kidney weight0.51.42.6-1.6-1.1-1.3-1.4-0.41.1-1.3-0.6
Right kidney weight0.30.84.0-2.0-0.4-0.6-0.90.10.6-0.6-0.1
Cocaine induced anxiety0.30.40.80.40.40.90.60.4-0.70.90.4
Post-drug Anxiety0.40.50.70.40.80.90.70.5-0.70.80.5
Baseline Anxiety0.10.10.2-0.50.4-0.10.20.2-0.1-0.10.3
Tail length1.75.229.3-5.40.50.21.22.3-1.21.21.4
Length with tail1.65.741.7-6.5-0.6-1.2-0.01.30.0-0.20.5
Length without tail1.22.66.6-2.6-1.5-2.0-1.4-0.71.5-1.6-1.0
Times rat made contact with spout2.32.73.71.0-1.8-1.6-1.0-1.91.7-1.8-1.8
Lifetime Intake0.40.41.4-1.2-0.6-0.4-0.3-0.30.8-0.8-0.3
Liver weight, left0.61.01.30.7-1.0-0.8-1.0-1.21.0-1.1-1.1
Liver weight, right0.10.10.8-0.9-0.3-0.2-0.30.0-0.0-0.1-0.0
Locomotor activity3.75.98.30.4-2.9-2.7-2.5-2.32.7-2.7-2.2
Locomotor testing distance4.77.99.91.6-3.0-2.8-2.7-3.03.2-3.1-2.8
Locomotor testing rearing1.82.73.61.0-1.9-1.7-1.3-1.81.8-1.5-1.9
Locomotion in novel chamber0.20.30.70.80.4-0.10.70.4-0.60.50.3
Locomotion in novel chamber post-restriction1.51.82.6-1.31.41.41.61.4-1.21.21.1
Fecal boli incidents, locomotor time 11.11.21.5-1.11.00.91.21.2-1.11.11.1
Change in fecal boli incidents, locomotor task0.30.31.21.1-0.3-0.1-0.3-0.70.3-0.5-0.3
Time >=10cm from walls, locomotor time 10.70.71.10.7-0.2-0.7-1.0-0.80.9-1.0-0.9
Bouts of movement, locomotor time 10.10.10.40.1-0.1-0.0-0.6-0.20.4-0.2-0.5
Total resting periods, locomotor time 10.10.10.40.1-0.1-0.1-0.7-0.20.3-0.1-0.4
Rest time, locomotor task time 10.60.61.0-0.21.00.80.90.7-0.90.90.6
Distance moved, locomotor task time 12.62.94.31.4-2.1-1.7-1.7-1.81.7-1.6-1.5
Vertical activity count, locomotor time 14.24.45.61.7-2.1-1.9-2.4-2.22.3-2.2-1.8
Time >=10cm from walls, locomotor time 20.70.81.91.4-0.4-1.0-0.5-1.00.5-0.7-1.0
Bouts of movement, locomotor time 20.40.40.8-0.9-0.0-0.4-0.6-0.30.9-0.7-0.6
Total resting periods, locomotor time 20.50.51.1-0.6-0.3-0.6-0.7-0.51.1-0.8-0.7
Rest time, locomotor task time 20.10.20.30.5-0.20.3-0.6-0.50.3-0.4-0.3
Distance moved, locomotor task time 20.30.40.60.3-0.7-0.8-0.8-0.70.6-0.5-0.6
Vertical activity count, locomotor time 21.31.42.40.4-1.3-1.4-1.6-1.11.2-1.2-1.0
Light reinforcement 10.00.00.10.0-0.30.0-0.3-0.20.2-0.10.3
Light reinforcement 21.01.32.1-0.61.21.51.21.3-1.01.11.3
Bone: marrow area0.10.30.70.7-0.5-0.4-0.2-0.40.8-0.7-0.3
Bone: maximum diameter1.52.84.20.9-1.7-1.5-1.6-1.72.0-2.0-1.8
Bone: maximum force0.20.41.00.5-0.7-0.6-0.6-0.60.6-0.6-1.0
Bone: maximum moment0.50.81.80.8-0.8-0.9-0.8-0.90.8-0.8-1.3
Mean time between licks in bursts1.52.13.70.5-1.4-1.0-1.9-1.51.7-1.7-1.5
Mean num. licks in bursts0.00.00.10.1-0.2-0.10.1-0.10.0-0.0-0.3
Cd content in liver1.21.32.20.1-1.1-1.1-1.5-1.11.3-1.3-1.1
Co content in liver0.20.21.2-1.10.3-0.10.30.10.3-0.30.3
Cu content in liver0.70.82.5-1.61.11.10.60.7-0.30.30.8
Fe content in liver0.10.10.2-0.2-0.50.10.30.2-0.30.30.2
K content in liver5.35.36.4-2.12.01.82.52.3-2.52.52.4
Mg content in liver0.80.91.3-0.91.00.70.80.9-0.90.91.2
Mn content in liver0.10.10.10.1-0.1-0.3-0.3-0.30.3-0.3-0.0
Na content in liver0.80.91.3-0.60.80.81.20.9-1.01.01.0
Rb content in liver6.07.49.0-2.53.02.93.02.9-2.52.52.4
Se content in liver0.10.10.7-0.2-0.4-0.3-0.2-0.0-0.20.20.8
Sr content in liver0.50.41.10.8-1.0-0.80.1-0.50.1-0.2-0.9
Zn content in liver0.91.04.2-2.01.00.9-0.20.8-0.50.50.9
Bone: minimum diameter3.15.87.61.1-2.8-2.6-2.1-2.42.7-2.7-2.5
Time in familiar zone, hab. session 10.10.10.3-0.00.30.2-0.50.1-0.0-0.00.5
Time in novel zone, hab. session 10.00.00.10.10.20.30.2-0.10.2-0.1-0.3
Total zone transitions, hab. session 14.66.412.42.4-3.5-3.0-2.3-2.52.0-1.9-2.1
Total locomotion distance, hab. session 14.15.910.02.2-3.2-3.0-2.3-2.52.1-2.0-1.8
Locomotion velocity, hab. session 15.88.314.42.6-3.8-3.6-2.7-2.92.4-2.3-2.2
Time in familiar zone, hab. session 20.40.41.6-0.60.1-0.1-1.3-0.40.5-0.6-0.4
Time in novel zone, hab. session 20.20.20.40.5-0.10.20.50.3-0.50.60.2
Total zone transitions, hab. session 24.45.710.02.3-3.2-2.9-2.5-2.31.8-1.7-2.1
Total locomotion distance, hab. session 26.89.012.22.9-3.4-3.5-3.1-3.12.6-2.6-2.6
Locomotion velocity, hab. session 26.89.112.93.0-3.5-3.6-3.0-3.12.6-2.6-2.6
Novel to familiar place preference ratio2.22.34.1-2.01.61.60.81.5-1.31.51.5
Novelty place preference2.22.34.0-2.01.61.80.61.4-1.31.41.5
Time in novel zone, NPP test1.61.73.5-1.91.41.60.41.2-1.01.21.2
Total zone transitions, NPP test2.23.27.11.4-2.7-2.2-1.9-1.61.3-1.3-1.6
Total locomotion distance, NPP test3.24.47.51.6-2.7-2.7-2.2-2.01.8-1.7-1.5
Locomotion velocity, NPP test2.02.85.51.6-2.3-2.3-1.6-1.61.2-1.1-1.1
Intraocular pressure0.10.20.90.90.20.00.80.1-0.20.20.0
Delta distance traveled before/after self-admin0.10.10.6-0.0-0.8-0.5-0.4-0.10.2-0.3-0.1
Delta ambulatory time before/after self-admin0.10.10.40.1-0.7-0.4-0.3-0.00.1-0.10.0
Parametrial fat weight0.30.62.01.4-0.6-0.6-0.7-0.70.6-0.7-0.4
Pavlov. Cond. lever latency0.30.41.9-1.40.60.40.10.60.0-0.00.4
Pavlov. Cond. magazine entry latency2.02.53.92.0-1.7-1.7-1.7-1.61.3-1.4-1.2
Pavlov. Cond. change in total contacts1.92.14.12.0-1.5-1.5-0.8-1.51.4-1.3-1.2
Pavlov. Cond. index score2.12.75.22.3-1.8-1.7-1.4-1.71.2-1.2-1.5
Pavlov. Cond. latency score1.51.94.62.1-1.6-1.4-1.0-1.50.8-0.8-1.2
Pavlov. Cond. lever contacts0.81.02.61.6-1.2-1.1-0.4-1.10.6-0.5-0.9
Pavlov. Cond. magazine entry number1.82.33.8-1.91.51.61.41.5-1.41.41.2
Pavlov. Cond. intertrial magazine entries0.60.71.20.7-0.9-0.8-0.7-0.81.1-1.1-0.6
Pavlov. Cond. lever-magazine prob. diff.2.63.25.52.3-1.9-1.9-1.6-1.91.4-1.4-1.6
Pavlov. Cond. response bias2.32.75.22.3-1.7-1.8-1.3-1.71.5-1.4-1.3
Pavlov. Cond. lever latency0.60.81.6-0.91.31.01.10.9-0.50.60.4
Pavlov. Cond. magazine entry latency0.40.50.70.7-0.8-0.7-0.6-0.80.7-0.6-0.6
Pavlov. Cond. change in total contacts2.23.06.50.9-2.5-2.2-1.7-1.61.5-1.5-1.3
Pavlov. Cond. index score1.01.32.60.9-1.6-1.3-1.1-1.21.0-0.9-0.7
Pavlov. Cond. latency score0.60.71.80.8-1.3-1.1-0.8-0.90.6-0.6-0.5
Pavlov. Cond. lever contacts2.33.14.91.6-2.2-1.9-1.9-1.81.6-1.6-1.3
Pavlov. Cond. magazine entry number2.22.74.2-1.62.11.81.51.8-1.61.51.3
Pavlov. Cond. intertrial magazine entries0.30.41.0-1.00.80.8-0.80.30.0-0.10.1
Pavlov. Cond. lever-magazine prob. diff.0.91.22.60.9-1.6-1.3-1.0-1.10.9-0.9-0.7
Pavlov. Cond. response bias3.04.06.01.8-2.4-2.2-2.0-2.11.9-1.9-1.6
Time in closed arm before self-admin0.00.00.2-0.5-0.10.1-0.20.2-0.1-0.2-0.0
Time in closed arm after self-admin0.30.30.80.9-0.2-0.0-0.3-0.50.7-0.7-0.5
Time in open arm before self-admin0.00.00.10.4-0.30.0-0.3-0.10.00.30.0
Time in open arm after self-admin0.10.10.4-0.1-0.10.10.20.2-0.70.60.3
Bone: periosteal estimation0.51.11.80.7-1.1-0.9-0.8-0.91.3-1.2-1.1
Bone: periosteal perimeter1.22.02.71.0-1.5-1.4-1.1-1.31.6-1.6-1.6
Bone: post-yield work0.10.10.3-0.60.20.40.20.1-0.40.30.2
Progressive ratio test 1 active lever presses0.80.85.3-2.30.30.10.70.60.0-0.00.5
Progressive ratio test 1 breakpoint0.50.64.1-2.00.1-0.20.30.30.3-0.40.2
Progressive ratio test 1 inactive lever presses0.60.72.9-1.70.70.30.30.7-0.60.60.7
Progressive ratio test 2 active lever presses0.20.21.4-1.2-0.3-0.30.0-0.00.3-0.30.1
Progressive ratio test 2 breakpoint0.40.41.0-1.0-0.6-0.8-0.2-0.40.8-0.7-0.3
Progressive ratio test 2 inactive lever presses0.30.41.1-1.10.40.10.70.6-0.60.50.7
Incentive Sensitization - Responses0.20.20.7-0.9-0.4-0.6-0.3-0.20.4-0.4-0.1
Incentive Sensitization - Breakpoint0.10.20.8-0.9-0.2-0.4-0.1-0.00.2-0.20.1
Sum of active levers in priming session hrs 5-64.44.25.51.8-2.0-2.4-2.2-2.12.0-2.1-1.9
Progressive ratio0.40.50.80.10.80.40.90.8-0.70.90.7
Food seeking constrained by brief footshock0.20.21.2-1.1-0.1-0.20.10.30.2-0.20.3
Seeking ratio, punishment vs. effort0.30.40.6-0.5-0.7-0.4-0.7-0.50.6-0.8-0.5
Retroperitoneal fat weight0.72.44.1-0.4-2.0-2.0-1.6-1.41.6-1.6-1.0
Reaction time number correct0.30.50.90.9-0.6-0.7-0.4-0.70.6-0.6-0.8
Reaction time mean minus median0.60.81.6-0.71.30.90.20.8-1.01.10.6
Reaction time mean minus median AUC0.20.30.8-0.60.90.3-0.30.5-0.50.60.3
Reaction time num false alarms1.01.32.4-1.01.21.50.61.2-1.01.21.1
Reaction time num false alarms AUC0.70.91.7-0.81.01.30.31.0-0.91.00.9
Reaction time trials correct on left0.30.50.90.9-0.6-0.7-0.4-0.70.6-0.6-0.8
Reaction time trials on left0.30.51.01.0-0.6-0.6-0.4-0.70.5-0.6-0.8
Reaction time mean0.50.71.80.4-0.5-0.6-1.3-0.80.9-1.0-0.8
Reaction time mean AUC0.30.41.3-0.0-0.3-0.5-1.1-0.60.8-0.8-0.6
Median of all reaction times1.21.62.90.4-1.1-1.1-1.7-1.21.5-1.6-1.0
Reaction time omissions0.50.62.10.51.41.4-0.30.4-0.50.60.2
Reaction time false alarm rate1.11.62.5-1.11.31.60.71.3-1.21.31.3
Reaction time premature initiation rate1.41.93.51.9-1.6-1.5-1.3-1.40.9-0.9-1.2
Reaction time premature initiations1.41.93.41.8-1.6-1.5-1.2-1.40.9-0.9-1.3
Std. dev. reaction times0.30.40.9-0.41.00.8-0.30.5-0.60.60.2
Reaction time trials completed0.30.51.01.0-0.6-0.6-0.4-0.70.5-0.6-0.8
Reaction time trials AUC0.40.61.01.0-0.7-0.7-0.5-0.80.6-0.7-0.8
Run reversals in cocaine runway, females0.00.00.1-0.3-0.3-0.20.0-0.10.1-0.0-0.3
Run reversals in cocaine runway, males0.20.20.30.2-0.5-0.4-0.5-0.60.6-0.5-0.4
Latency to leave start box in cocaine runway0.80.91.31.2-0.8-0.6-1.1-1.11.0-0.9-0.8
Latency to leave start box in cocaine runway, F1.71.92.71.5-1.3-1.0-1.6-1.51.5-1.4-0.9
Latency to leave start box in cocaine runway, M1.41.41.8-1.21.21.11.11.2-1.31.30.9
Std. dev. time between licks in bursts2.22.75.11.2-1.5-1.8-2.3-1.51.6-1.6-1.4
Total sessions with >9 infusions0.20.31.1-1.00.20.30.80.3-0.10.10.3
Short access day 1 total inactive lever presses0.00.00.1-0.2-0.0-0.30.10.10.0-0.00.1
Short access day 10 total inactive lever presses0.50.51.40.41.20.9-0.10.5-0.80.90.5
Short access day 1 total infusions0.30.30.8-0.0-0.5-0.4-0.2-0.50.9-0.9-0.5
Short access day 10 total infusions0.60.72.0-1.4-0.7-0.7-0.6-0.30.9-0.9-0.3
Short access total infusions1.01.12.1-0.4-1.1-1.1-0.7-1.01.4-1.4-0.9
Short access day 1 locomotion0.10.10.6-0.80.3-0.10.30.00.1-0.10.0
Short access day 10 total locomotion0.20.30.7-0.80.40.20.20.7-0.50.50.5
Short access total locomotion0.20.21.1-1.10.1-0.30.40.4-0.10.00.3
One hour access (0.3 mA shock)0.60.81.4-0.9-1.0-1.2-0.5-0.70.9-0.9-0.6
Compulsive drug intake0.70.71.50.90.90.50.80.6-1.21.10.6
One hour access (shock baseline)1.01.12.5-1.6-1.1-1.0-0.7-0.71.2-1.1-0.7
Social response proportion1.01.12.90.5-1.1-1.7-1.0-0.80.9-1.1-0.9
Social responses3.64.69.11.6-2.1-3.0-2.0-2.02.0-2.0-2.0
Social time0.70.92.30.9-1.1-1.5-0.2-0.90.8-0.7-1.1
Soleus weight0.20.61.10.3-0.5-1.0-0.6-0.71.0-1.0-0.9
Bone: stiffness0.91.53.10.6-1.8-1.7-1.2-0.91.0-1.0-1.1
Tibialis anterior weight0.30.91.90.7-0.6-1.0-1.0-1.00.9-0.9-1.4
Time to tail flick, vehicle, before self-admin0.50.51.10.3-0.6-1.0-0.2-0.50.9-0.9-0.7
Time to tail flick, vehicle, after self-admin0.91.01.51.1-0.8-0.9-1.2-1.01.0-1.1-0.8
Time to tail flick, test, before self-admin0.20.20.50.10.10.50.40.7-0.30.50.5
Time to tail flick, test, after self-admin0.30.30.70.8-0.8-0.5-0.1-0.30.3-0.4-0.5
Delta time to tail flick, vehicle, before/after SA0.30.30.80.8-0.1-0.2-0.9-0.60.3-0.4-0.4
Delta time to tail flick, test, before/after SA0.40.40.70.3-0.7-0.9-0.4-0.70.4-0.6-0.6
Tibia length1.64.45.9-1.6-2.3-2.4-2.2-1.42.4-2.4-1.8
Ambulatory time before self-admin0.00.00.10.2-0.00.10.2-0.00.00.0-0.0
Ambulatory time after self-admin0.70.71.30.6-1.1-1.1-0.9-0.70.8-0.9-0.6
Bone: tissue strength0.30.30.70.6-0.7-0.9-0.3-0.40.3-0.3-0.6
Total heroin consumption1.11.32.41.5-1.0-1.2-1.2-1.20.7-0.9-1.0
Bone: trabecular number0.40.72.10.40.70.31.40.7-0.90.90.6
Bone: trabecular spacing0.10.10.8-0.30.20.9-0.40.10.0-0.00.2
Bone: trabecular thickness0.00.00.2-0.50.10.1-0.00.2-0.10.2-0.1
Bone: trabecular tissue density0.10.10.3-0.0-0.5-0.20.2-0.0-0.40.40.4
Water consumed over 24 hours0.40.52.6-1.60.80.80.20.3-0.0-0.10.3
Number of responses in last shaping day0.10.10.30.1-0.5-0.50.3-0.20.1-0.1-0.2