Hub : Genes

Cpt1a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Cpt1a 0.08 0.06 2.2e-06 0.04 0.04 0.03 0.04 1.3e-05 1.3e-05 2.9e-04 1.8e-05
2 Brain gene expression Cpt1a 0.22 0.09 0.0e+00 0.26 0.17 0.23 0.24 1.1e-24 3.2e-15 1.6e-21 1.8e-22
3 Adipose gene expression Cpt1a 0.06 0.04 2.3e-05 0.01 0.03 0.02 0.02 9.8e-03 5.3e-04 1.5e-03 3.6e-03
4 BLA gene expression Cpt1a 0.14 0.09 2.7e-05 0.07 0.08 0.06 0.07 1.0e-04 6.3e-05 2.7e-04 8.5e-05
5 LHb gene expression Cpt1a 0.44 0.33 1.9e-03 0.13 0.09 0.12 0.08 5.8e-04 4.8e-03 9.1e-04 7.2e-03
6 PL gene expression Cpt1a 0.07 0.05 4.4e-06 0.05 0.04 0.04 0.04 6.6e-06 2.6e-05 2.2e-05 4.9e-05
7 OFC gene expression Cpt1a 0.32 0.17 6.1e-05 0.21 0.16 0.23 0.2 9.4e-06 1.6e-04 3.9e-06 1.6e-05
8 BLA mRNA stability Cpt1a 0.09 0.06 1.7e-04 0.06 0.05 0.06 0.04 5.2e-04 1.7e-03 4.9e-04 2.1e-03
9 PL mRNA stability Cpt1a 0.04 0.03 3.5e-04 0.04 0.04 0.04 0.04 3.4e-05 6.7e-05 5.4e-05 3.7e-05
10 pVTA gene expression Cpt1a 0.31 0.21 3.4e-08 0.15 0.16 0.14 0.14 6.9e-07 1.2e-07 1.2e-06 7.9e-07
11 Liver mRNA stability Cpt1a 0.06 0.04 9.2e-05 0.01 0.03 0.02 0.02 1.1e-02 5.5e-04 2.4e-03 2.0e-03
12 Liver alternative TSS XM_017588837.1 0.04 0.02 6.1e-04 0.01 0.03 0.02 0.02 2.6e-02 7.5e-04 3.7e-03 3.1e-03
13 Brain mRNA stability Cpt1a 0.04 0.03 9.6e-04 0.04 0.03 0.02 0.03 1.5e-04 6.6e-04 3.3e-03 7.3e-04
14 Liver isoform ratio XM_017588837.1 0.05 0.03 3.5e-05 0.01 0.04 0.02 0.03 1.1e-02 8.2e-05 9.6e-04 4.0e-04
15 Liver alternative TSS NM_031559.2 0.05 0.04 1.0e-04 0.04 0.04 0.04 0.05 1.1e-05 8.3e-05 5.3e-05 3.2e-06
16 Liver isoform ratio NM_031559.2 0.03 0.02 3.9e-04 0.03 0.03 0.01 0.03 1.3e-04 3.8e-04 1.5e-02 4.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density2.54.16.61.61.5-1.6-1.61.61.42.11.52.0-2.2-2.2-2.52.5-2.62.5-2.5
Area under the delay curve0.80.91.40.90.9-0.6-0.90.71.00.91.10.8-1.1-1.0-1.20.9-1.20.9-0.9
BMI with tail1.75.612.00.40.5-3.5-0.30.30.30.63.23.2-1.7-3.4-2.33.3-2.53.2-3.1
BMI without tail1.22.48.10.10.1-2.2-0.10.10.20.11.92.8-1.0-2.1-1.42.0-1.51.9-1.9
Body weight0.93.813.6-2.3-2.3-3.72.2-2.2-2.1-1.60.21.40.7-2.3-0.12.2-0.42.0-1.9
Weight adjusted by age0.50.61.4-1.0-1.0-1.11.0-1.2-0.9-1.10.20.40.5-0.60.30.20.20.1-0.1
Bone surface2.54.38.80.80.7-2.5-0.80.80.61.61.82.6-1.7-2.7-2.33.0-2.43.0-3.0
Bone volume1.93.25.41.21.2-1.5-1.31.21.01.91.11.9-1.8-2.0-2.22.3-2.32.3-2.3
Breakpoint value in progressive ratio session0.70.82.4-0.9-0.9-1.61.0-1.1-1.1-0.81.2-0.00.3-1.10.00.9-0.00.9-0.9
Number of licking bursts0.20.21.20.30.3-0.2-0.30.30.20.31.11.0-0.4-0.3-0.40.4-0.40.4-0.4
Context. condit. distance diff. score0.40.51.10.90.90.6-1.00.90.91.10.7-0.6-0.80.1-0.60.0-0.50.0-0.0
Locomotion velocity, session 10.10.11.10.30.3-0.1-0.10.30.2-0.20.51.1-0.2-0.2-0.20.3-0.10.3-0.3
Locomotion distance, session 11.52.03.21.00.9-1.2-1.00.90.91.31.31.7-1.4-1.6-1.61.8-1.71.8-1.8
Locomotion velocity, session 20.91.02.1-1.3-1.3-1.41.3-1.4-1.4-1.1-0.11.00.7-0.70.30.70.20.7-0.7
Locomotion distance, session 20.50.71.60.30.3-1.1-0.20.20.20.70.71.2-0.6-1.1-0.91.2-1.01.2-1.2
Locomotion velocity, session 31.82.15.01.21.2-0.9-1.21.21.21.01.52.2-1.5-1.4-1.61.6-1.61.7-1.7
Locomotion distance, session 30.10.10.30.20.2-0.2-0.20.20.20.20.30.5-0.3-0.3-0.40.4-0.40.4-0.4
Stereotopy head waving bouts, day 31.31.62.31.21.3-0.5-1.31.31.31.30.81.3-1.5-1.1-1.51.2-1.51.2-1.2
Stereotopy head waving duration, day 31.01.12.11.41.40.3-1.51.41.51.40.20.7-1.3-0.4-1.20.6-1.10.6-0.6
Locomotion velocity, session 70.70.81.40.60.6-0.8-0.70.50.50.50.60.7-1.1-1.2-1.11.1-1.11.1-1.1
Locomotion distance, session 70.10.20.5-0.3-0.3-0.70.2-0.3-0.3-0.10.00.2-0.1-0.6-0.30.5-0.30.6-0.6
Stereotopy head waving bouts, day 71.51.72.71.51.5-0.1-1.51.61.61.40.91.2-1.5-0.8-1.51.1-1.51.1-1.1
Stereotopy head waving duration, day 71.72.04.20.70.7-1.5-0.60.80.90.51.62.1-1.3-1.8-1.51.9-1.51.9-1.9
Locomotion velocity, session 80.60.72.0-1.0-0.9-1.41.0-1.0-1.0-1.00.10.80.4-0.90.10.70.10.8-0.8
Locomotion distance, session 80.40.61.81.01.00.2-1.01.00.91.30.20.1-0.9-0.3-0.90.5-0.90.5-0.5
Degree of sensitization distance0.20.20.6-0.1-0.0-0.80.0-0.1-0.0-0.00.10.3-0.3-0.8-0.40.6-0.50.6-0.6
Degree of sensitization stereotypy0.80.91.60.70.6-0.8-0.60.70.80.61.01.3-0.9-1.0-1.01.2-1.01.2-1.2
Conditioned locomotion2.42.95.0-2.2-2.2-0.42.2-2.1-2.1-2.0-1.1-1.32.10.71.9-1.01.8-1.01.0
Cocaine response after cond. corrected0.10.10.50.40.40.2-0.40.40.40.7-0.2-0.7-0.3-0.0-0.30.1-0.30.1-0.1
Cocaine response after cond. not corrected0.50.51.70.90.80.0-0.90.90.81.30.3-0.2-0.8-0.4-0.80.6-0.90.6-0.6
Cocaine response before conditioning0.40.51.90.50.5-0.3-0.50.50.40.71.21.4-0.5-0.4-0.60.7-0.70.7-0.7
Saline control response0.91.23.4-1.3-1.3-1.81.3-1.4-1.5-1.10.11.30.5-1.10.11.0-0.01.0-1.0
Bone: connectivity density2.94.68.80.90.9-2.5-0.80.90.81.42.32.7-1.8-2.8-2.33.0-2.53.0-3.0
Bone: cortical apparent density0.50.61.3-1.0-1.0-0.81.1-1.0-1.0-1.10.9-0.90.7-0.30.6-0.10.6-0.10.1
Bone: cortical area0.40.61.2-0.9-0.90.10.8-0.9-1.00.1-0.9-1.11.00.60.8-0.50.7-0.50.5
Bone: cortical porosity0.10.10.30.40.4-0.1-0.40.40.40.60.20.0-0.4-0.2-0.40.2-0.40.2-0.2
Bone: cortical porosity0.10.10.2-0.3-0.2-0.50.3-0.3-0.30.10.20.10.1-0.3-0.00.3-0.10.3-0.3
Bone: cortical thickness2.43.98.0-2.8-2.8-0.82.8-2.8-2.8-1.7-0.9-1.22.60.72.2-0.92.0-0.90.9
Bone: cortical thickness0.91.12.5-1.5-1.5-0.81.6-1.5-1.5-1.2-0.00.11.30.11.0-0.20.9-0.20.2
Bone: cortical tissue density0.60.81.6-1.1-1.1-0.81.3-1.1-1.1-1.30.9-0.80.8-0.30.7-0.10.7-0.10.1
Condit. Reinf. active minus inactive responses0.50.61.10.80.8-0.4-0.70.80.91.10.4-0.2-0.8-0.7-0.90.9-0.90.9-0.9
Condit. Reinf. active-inactive response ratio0.50.51.80.80.80.0-0.80.90.91.30.1-0.6-0.7-0.3-0.70.5-0.80.6-0.6
Condit. Reinf. active responses0.20.20.50.60.60.0-0.40.60.60.7-0.0-0.5-0.4-0.2-0.40.3-0.30.3-0.3
Condit. Reinf. inactive responses0.00.00.10.00.00.30.10.00.0-0.3-0.2-0.00.20.30.3-0.30.3-0.30.3
Incentive salience index mean0.40.51.30.70.7-0.3-0.60.80.71.1-0.1-0.5-0.7-0.6-0.70.8-0.70.8-0.8
Condit. Reinf. lever presses0.10.21.60.10.10.20.00.10.10.5-1.0-1.30.10.20.2-0.10.2-0.10.1
Condit. Reinf. active minus inactive responses1.92.44.62.12.10.0-1.82.12.01.50.81.2-1.8-0.9-1.71.2-1.61.2-1.2
Condit. Reinf. active-inactive response ratio1.92.05.02.22.20.9-2.02.22.11.5-0.20.4-1.5-0.0-1.20.4-1.10.3-0.4
Condit. Reinf. active responses1.92.63.41.71.7-0.9-1.41.71.61.01.71.7-1.8-1.6-1.81.7-1.81.7-1.7
Condit. Reinf. inactive responses1.11.33.30.00.1-1.70.00.00.2-0.01.81.6-0.8-1.7-1.01.5-1.01.5-1.5
Condit. Reinf. lever presses0.91.32.70.50.6-1.2-0.50.60.70.71.11.6-0.9-1.3-1.21.5-1.21.5-1.5
Condit. Reinf. lever reinforcers received1.82.63.41.51.5-1.1-1.31.61.50.91.71.7-1.8-1.8-1.81.8-1.81.8-1.8
Conditioned reinforcement - actives0.40.40.8-0.3-0.30.80.3-0.5-0.5-0.8-0.7-0.40.60.90.8-0.40.8-0.50.5
Conditioned reinforcement - inactives1.92.15.91.91.92.4-1.91.71.71.7-0.5-1.3-0.81.5-0.3-1.0-0.2-1.01.0
Conditioned locomotion2.73.213.41.41.43.7-1.51.11.21.1-2.1-1.60.22.90.8-1.81.0-2.02.0
Patch foraging indifference point 0 sec0.00.10.30.30.30.2-0.30.40.50.00.00.3-0.3-0.1-0.20.2-0.20.1-0.1
Patch foraging indifference point AUC0.60.71.5-1.1-1.2-0.71.2-1.0-0.9-0.6-1.2-0.40.9-0.00.8-0.10.7-0.10.1
Delay disc. indifference point, 0s delay2.12.33.41.41.4-0.9-1.31.21.31.41.81.6-1.6-1.4-1.71.7-1.71.7-1.7
Delay disc. indifference point, 16s delay0.70.72.11.11.11.0-1.21.01.21.5-0.5-0.4-0.80.4-0.6-0.3-0.6-0.40.4
Delay disc. indifference point, 2s delay0.60.61.10.90.90.0-1.00.71.11.0-0.10.4-1.0-0.4-0.90.8-0.90.7-0.7
Delay disc. indifference point, 24s delay0.40.40.9-0.8-0.90.00.7-0.9-0.8-0.7-0.0-0.10.70.40.7-0.70.6-0.70.7
Delay disc. indifference point, 4s delay0.30.30.60.50.5-0.5-0.40.30.70.20.40.4-0.7-0.8-0.70.6-0.70.7-0.7
Delay disc. indifference point, 8s delay0.30.31.80.20.2-0.6-0.30.10.20.21.40.5-0.5-0.7-0.60.6-0.70.6-0.6
Indifference point function ln k1.01.44.61.51.42.1-1.51.31.31.0-0.5-1.2-0.61.3-0.2-0.9-0.0-0.90.9
Indifference point function log k1.01.44.61.51.42.1-1.51.31.31.0-0.5-1.2-0.61.3-0.2-0.9-0.0-0.90.9
Patch foraging total patch changes 0 sec0.10.10.5-0.4-0.40.20.3-0.2-0.1-0.6-0.7-0.10.30.20.4-0.20.4-0.20.2
Patch foraging total patch changes 12 sec0.81.02.8-1.4-1.4-1.71.4-1.0-1.0-1.30.20.90.7-1.00.40.80.30.8-0.7
Patch foraging total patch changes 18 sec0.20.20.6-0.3-0.3-0.80.3-0.2-0.20.1-0.50.3-0.1-0.6-0.20.7-0.20.7-0.7
Patch foraging total patch changes 24 sec0.81.02.3-1.5-1.5-0.71.3-1.3-1.3-1.2-1.30.21.0-0.00.80.00.70.0-0.0
Patch foraging total patch changes 6 sec0.60.82.9-0.2-0.2-1.50.2-0.00.0-0.10.61.7-0.4-1.3-0.71.4-0.71.3-1.3
Patch foraging time to switch 0 sec2.03.19.60.60.7-2.1-0.60.70.70.63.12.2-1.5-2.4-1.92.1-2.02.0-2.0
Patch foraging water rate 0 sec2.94.712.4-0.3-0.43.30.2-0.3-0.3-0.4-3.5-2.81.53.22.1-2.72.3-2.72.7
Patch foraging water rate 12 sec3.65.516.30.30.54.0-0.60.30.40.6-3.2-2.51.33.81.9-3.22.1-3.23.1
Patch foraging water rate 18 sec0.81.03.30.50.61.8-0.60.60.50.4-1.5-0.80.21.50.5-1.30.6-1.41.4
Patch foraging water rate 24 sec2.43.37.9-0.5-0.52.50.3-0.5-0.6-0.5-2.8-2.41.42.61.8-2.31.9-2.32.3
Patch foraging water rate 6 sec2.13.111.2-0.7-0.82.10.5-0.9-0.8-0.6-3.3-2.31.52.41.8-2.01.8-1.91.9
Seeking ratio, delayed vs. immediate footshock0.81.02.50.60.6-0.9-0.50.50.40.61.61.1-0.9-1.1-1.01.4-1.01.3-1.3
Distance traveled before self-admin0.20.20.60.20.2-0.4-0.20.40.20.40.30.8-0.3-0.4-0.40.4-0.40.6-0.6
Distance traveled after self-admin0.20.21.20.30.3-0.1-0.30.70.50.6-0.11.1-0.3-0.2-0.40.5-0.40.5-0.5
Extensor digitorum longus weight2.18.218.4-4.3-4.2-3.94.2-4.2-4.1-3.0-0.3-0.12.6-1.71.61.21.31.2-1.2
Bone: elastic displacement2.73.15.6-1.3-1.31.41.2-1.3-1.3-0.9-2.4-2.11.92.02.0-2.02.0-2.12.1
Bone: elastic work1.52.03.8-1.9-1.9-0.31.8-1.9-1.9-1.5-1.00.01.80.71.5-0.81.4-0.80.8
Bone: endosteal estimation1.22.76.52.12.10.8-2.42.12.02.5-0.11.0-1.9-0.3-1.80.9-1.80.8-0.8
Bone: endosteal perimeter2.65.310.73.13.11.0-3.33.13.03.2-0.10.5-2.8-0.6-2.51.2-2.41.1-1.1
Epididymis fat weight1.43.38.12.32.32.7-2.42.32.32.8-1.8-1.1-1.11.6-0.7-0.9-0.5-1.01.0
Delta time in closed arm before/after self-admin0.90.82.4-1.1-1.2-0.51.2-1.4-1.5-1.40.6-0.01.00.20.8-0.40.8-0.20.1
Delta time in open arm before/after self-admin0.30.31.10.70.70.3-0.60.71.00.50.30.3-0.5-0.0-0.40.2-0.40.0-0.0
Diff in mean of infusions in LGA sessions0.30.30.8-0.6-0.7-0.50.7-0.9-0.8-0.60.8-0.00.5-0.10.40.10.40.2-0.2
Delay discount exponential model param0.60.61.0-0.6-0.70.50.7-0.5-0.8-0.7-0.9-0.60.90.81.0-0.81.0-0.80.7
Extinction: sum of active levers before priming1.11.14.2-0.7-0.7-2.00.8-0.8-0.7-0.31.10.7-0.1-1.6-0.51.2-0.71.3-1.3
Active lever presses in extinction session 61.41.42.7-1.5-1.6-0.31.5-1.6-1.5-1.2-0.9-0.81.50.61.3-0.51.3-0.80.8
Bone: final force0.50.72.6-0.7-0.6-1.60.7-0.7-0.7-0.20.41.00.0-1.2-0.31.2-0.41.2-1.2
Bone: final moment0.40.62.1-0.6-0.6-1.40.6-0.6-0.7-0.10.30.80.1-1.0-0.31.1-0.41.1-1.1
Food consumed during 24 hour testing period0.20.20.90.20.21.0-0.30.10.10.4-0.2-0.10.20.90.3-0.60.3-0.60.6
Glucose2.13.16.12.42.50.5-2.32.42.42.20.90.6-2.1-0.7-1.91.0-1.81.0-1.0
Heart weight0.70.92.11.41.31.0-1.31.41.41.4-0.9-0.4-0.90.3-0.60.1-0.60.1-0.1
Delay discount hyperbolic model param0.60.61.0-0.7-0.70.60.7-0.5-0.8-0.7-0.8-0.60.90.91.0-0.91.0-0.80.8
Intermittent access intake day 1-15 change0.80.82.80.60.61.6-0.50.30.40.4-1.1-1.70.11.20.4-0.90.5-0.90.8
Intermittent access intake escalation0.60.61.80.90.91.4-0.80.70.70.7-0.5-1.2-0.30.90.0-0.70.1-0.70.6
Intermittent access intake escalation 20.60.62.40.40.41.1-0.30.20.30.3-1.3-1.60.10.90.3-0.90.4-0.90.9
Intermitt. access day 1 inactive lever presses0.50.61.11.01.01.0-1.00.80.81.0-0.2-0.8-0.60.5-0.3-0.7-0.2-0.60.6
Intermitt. access day 15 inactive lever presses1.01.12.31.51.51.1-1.51.51.51.30.6-0.5-1.00.4-0.8-0.3-0.7-0.20.2
Intermitt. access escalation Index1.00.92.60.90.91.6-0.90.70.70.9-0.7-1.1-0.21.20.2-1.10.3-1.11.1
Intermittent access day 1 total infusions4.24.88.73.03.00.5-2.82.92.82.71.91.1-2.6-0.9-2.41.3-2.31.2-1.2
Intermittent access day 15 total infusions3.33.78.42.92.92.2-2.82.72.72.60.2-0.8-1.80.8-1.3-0.2-1.2-0.30.3
Intermittent access terminal intake (last 3 days)2.93.17.22.72.71.5-2.62.52.52.50.5-0.7-1.90.2-1.50.1-1.40.1-0.1
Intermittent access total infusions2.42.65.82.42.41.0-2.32.22.22.11.10.1-1.9-0.2-1.60.5-1.50.4-0.4
Intermittent access day 1 locomotion2.62.74.52.12.1-0.2-1.91.91.91.81.91.2-2.0-1.1-1.91.0-1.81.0-1.0
Intermittent access day 15 total locomotion1.92.14.92.22.21.7-2.12.02.11.8-0.1-0.5-1.40.6-1.0-0.2-0.8-0.20.2
Intermittent access total locomotion4.04.610.13.23.21.4-3.02.93.02.91.10.2-2.4-0.1-2.00.5-1.90.4-0.3
Intermittent access standard deviation0.40.40.90.70.71.0-0.60.60.50.30.5-0.5-0.20.60.0-0.80.1-0.80.9
Left kidney weight0.51.44.30.70.62.1-0.70.80.61.0-1.8-1.60.21.80.5-1.30.6-1.41.4
Right kidney weight0.82.26.20.0-0.12.2-0.10.10.10.4-2.5-2.30.92.11.2-1.81.3-1.91.9
Cocaine induced anxiety0.00.10.50.20.20.2-0.20.10.00.40.70.1-0.00.2-0.10.2-0.10.1-0.1
Post-drug Anxiety0.80.92.0-1.3-1.3-0.61.3-1.4-1.3-1.10.3-0.41.10.10.9-0.30.8-0.30.3
Baseline Anxiety1.31.43.8-1.6-1.6-1.11.7-1.7-1.5-2.0-0.3-0.01.1-0.31.0-0.10.9-0.00.0
Tail length1.13.36.8-2.6-2.6-0.62.3-2.3-2.1-2.4-2.3-0.92.10.61.8-0.71.7-0.70.7
Length with tail1.65.813.1-3.5-3.6-2.03.4-3.3-3.3-3.0-2.7-1.02.5-0.22.00.11.8-0.00.1
Length without tail1.02.25.2-2.2-2.2-1.82.2-2.1-2.3-1.6-1.1-0.61.4-0.71.00.60.80.5-0.4
Times rat made contact with spout0.70.82.30.30.3-1.1-0.20.30.30.31.51.3-0.7-1.1-0.81.2-0.91.2-1.2
Lifetime Intake1.92.24.72.22.20.8-2.02.02.01.91.20.3-1.7-0.3-1.50.6-1.40.5-0.5
Liver weight, left0.20.31.60.40.40.6-0.50.20.20.9-1.3-1.0-0.20.4-0.1-0.3-0.1-0.30.3
Liver weight, right0.40.62.2-0.0-0.01.00.0-0.0-0.00.2-1.5-1.20.61.10.7-0.90.7-0.90.9
Locomotor activity0.50.84.30.40.51.6-0.50.40.30.7-2.1-0.40.31.40.4-0.90.5-1.01.0
Locomotor testing distance0.60.93.10.30.41.6-0.50.30.20.7-1.8-0.50.31.40.5-1.20.6-1.31.3
Locomotor testing rearing0.81.35.51.51.60.9-1.51.51.42.3-0.10.6-1.10.2-0.90.3-0.80.1-0.1
Locomotion in novel chamber2.22.76.42.52.42.2-2.42.12.32.40.1-0.9-1.50.9-1.0-0.2-0.8-0.20.2
Locomotion in novel chamber post-restriction1.11.33.51.41.41.9-1.41.21.21.40.7-1.3-0.61.1-0.2-1.1-0.1-1.01.0
Fecal boli incidents, locomotor time 10.10.10.20.40.40.3-0.30.40.30.30.40.0-0.20.1-0.10.2-0.10.3-0.3
Change in fecal boli incidents, locomotor task0.20.20.9-0.2-0.2-0.80.3-0.20.0-0.40.90.6-0.1-0.7-0.20.4-0.30.4-0.4
Time >=10cm from walls, locomotor time 13.23.24.72.12.1-0.0-2.12.12.21.82.01.7-2.0-1.0-1.91.5-1.91.5-1.5
Bouts of movement, locomotor time 11.21.32.7-1.6-1.7-0.51.5-1.5-1.6-1.60.5-0.41.20.11.1-0.51.1-0.40.4
Total resting periods, locomotor time 10.80.81.8-1.3-1.3-0.21.2-1.2-1.3-1.2-0.0-0.61.00.31.0-0.51.0-0.50.5
Rest time, locomotor task time 11.11.23.20.00.01.8-0.20.1-0.00.2-0.7-1.40.61.70.9-1.71.0-1.71.7
Distance moved, locomotor task time 11.01.11.81.00.8-0.9-0.70.81.00.71.00.8-1.1-1.3-1.21.4-1.21.3-1.3
Vertical activity count, locomotor time 10.70.81.91.41.30.5-1.21.21.31.10.4-0.1-1.0-0.1-0.90.2-0.80.2-0.2
Time >=10cm from walls, locomotor time 20.10.10.3-0.2-0.30.50.1-0.1-0.1-0.2-0.6-0.30.30.50.4-0.50.4-0.60.6
Bouts of movement, locomotor time 20.30.30.7-0.8-0.8-0.60.8-0.7-0.8-0.50.3-0.30.5-0.20.4-0.40.4-0.40.4
Total resting periods, locomotor time 20.10.10.6-0.4-0.4-0.40.4-0.3-0.5-0.10.8-0.10.2-0.30.1-0.30.1-0.30.3
Rest time, locomotor task time 21.82.14.52.02.00.9-1.92.11.92.01.80.4-1.40.1-1.20.1-1.10.1-0.2
Distance moved, locomotor task time 20.91.12.2-1.3-1.5-0.41.3-1.5-1.2-1.4-1.5-0.51.10.21.0-0.20.9-0.20.2
Vertical activity count, locomotor time 22.73.07.3-1.7-1.70.71.5-2.0-1.7-1.5-2.7-1.61.91.51.9-1.51.8-1.51.6
Light reinforcement 10.20.41.60.40.41.3-0.40.40.41.0-0.3-0.40.11.00.3-0.60.4-0.60.6
Light reinforcement 21.11.44.31.00.92.1-1.01.11.11.4-1.0-1.9-0.11.50.3-1.20.4-1.21.1
Bone: marrow area1.22.76.52.12.10.8-2.42.12.02.5-0.11.0-1.9-0.3-1.80.8-1.80.8-0.8
Bone: maximum diameter0.20.31.00.20.20.8-0.30.20.20.9-1.0-0.80.10.80.1-0.40.1-0.50.4
Bone: maximum force1.72.96.00.50.5-2.1-0.50.50.31.11.42.4-1.3-2.2-1.82.5-1.92.4-2.4
Bone: maximum moment1.42.35.00.40.4-1.9-0.50.40.21.21.12.2-1.2-1.9-1.62.2-1.82.2-2.2
Mean time between licks in bursts0.40.61.3-1.1-1.1-1.11.1-1.0-1.1-1.20.20.10.6-0.60.40.40.40.4-0.4
Mean num. licks in bursts0.10.10.20.20.2-0.4-0.10.10.20.2-0.3-0.3-0.3-0.4-0.30.4-0.30.4-0.4
Cd content in liver0.40.52.00.60.61.4-0.60.50.50.2-0.3-0.5-0.01.00.3-1.00.4-0.90.9
Co content in liver0.81.02.1-0.5-0.51.10.5-0.4-0.3-0.5-0.5-1.41.01.31.1-1.41.2-1.41.3
Cu content in liver0.20.20.6-0.7-0.7-0.10.5-0.6-0.6-0.2-0.8-0.30.50.20.4-0.30.3-0.30.3
Fe content in liver0.10.10.60.10.0-0.0-0.10.20.10.7-0.8-0.5-0.00.0-0.10.2-0.10.2-0.2
K content in liver1.41.42.80.40.4-1.4-0.40.50.50.91.21.7-1.0-1.5-1.31.5-1.41.5-1.5
Mg content in liver3.43.56.51.71.7-0.9-1.81.81.81.82.02.5-2.0-1.6-2.21.9-2.21.8-1.8
Mn content in liver0.30.31.2-0.6-0.7-1.10.6-0.5-0.5-0.1-0.50.50.2-0.7-0.10.6-0.20.6-0.6
Na content in liver0.30.30.5-0.6-0.60.30.5-0.6-0.6-0.3-0.6-0.20.70.60.6-0.50.6-0.50.5
Rb content in liver2.63.35.92.32.40.1-2.22.42.31.81.91.0-2.2-1.1-2.01.1-1.91.1-1.2
Se content in liver0.60.71.10.90.8-0.3-1.00.90.80.9-0.30.7-1.1-0.7-1.10.8-1.10.8-0.8
Sr content in liver1.41.32.9-1.6-1.6-0.81.7-1.6-1.7-1.30.1-0.41.40.11.1-0.21.1-0.20.2
Zn content in liver0.20.20.7-0.8-0.8-0.60.7-0.7-0.70.20.1-0.20.5-0.20.20.10.10.1-0.1
Bone: minimum diameter2.03.88.12.42.40.2-2.52.42.42.80.60.9-2.3-1.0-2.21.5-2.21.5-1.5
Time in familiar zone, hab. session 10.70.61.90.91.00.5-1.10.90.91.40.30.8-0.80.1-0.80.4-0.80.3-0.3
Time in novel zone, hab. session 10.20.20.8-0.5-0.5-0.20.6-0.5-0.5-0.90.3-0.40.4-0.10.4-0.20.5-0.20.2
Total zone transitions, hab. session 10.10.20.90.10.1-0.5-0.20.10.10.9-0.30.7-0.2-0.3-0.50.6-0.60.6-0.6
Total locomotion distance, hab. session 10.50.82.81.11.10.9-1.21.11.11.7-1.00.0-0.70.5-0.6-0.1-0.6-0.10.1
Locomotion velocity, hab. session 10.30.41.50.70.70.7-0.80.70.81.2-1.00.0-0.40.4-0.4-0.1-0.4-0.10.1
Time in familiar zone, hab. session 20.70.71.4-1.2-1.2-0.21.2-1.1-1.2-1.1-0.10.11.10.41.0-0.50.9-0.50.5
Time in novel zone, hab. session 21.11.11.51.01.0-0.5-1.01.01.00.71.20.7-1.2-1.0-1.21.1-1.21.1-1.1
Total zone transitions, hab. session 23.34.38.01.11.1-2.2-1.11.11.01.42.02.8-2.0-2.6-2.32.7-2.42.7-2.7
Total locomotion distance, hab. session 21.41.82.71.41.3-0.7-1.31.31.31.51.01.3-1.6-1.2-1.61.4-1.61.4-1.4
Locomotion velocity, hab. session 21.41.83.01.61.5-0.3-1.51.51.51.70.61.0-1.6-1.0-1.61.2-1.61.2-1.2
Novel to familiar place preference ratio0.40.41.00.20.3-0.8-0.20.10.10.01.00.8-0.6-1.0-0.70.8-0.70.8-0.8
Novelty place preference0.40.40.70.40.5-0.6-0.40.30.40.20.80.8-0.7-0.8-0.80.7-0.80.7-0.7
Time in novel zone, NPP test0.40.40.80.40.5-0.7-0.40.30.40.20.80.8-0.8-0.9-0.80.8-0.80.8-0.8
Total zone transitions, NPP test1.01.44.00.30.2-1.5-0.30.30.30.50.92.0-0.8-1.5-1.21.7-1.21.7-1.7
Total locomotion distance, NPP test0.50.60.90.90.8-0.2-0.90.90.90.90.50.8-0.9-0.6-0.90.8-0.90.8-0.8
Locomotion velocity, NPP test0.30.40.70.80.6-0.0-0.70.80.80.80.40.7-0.7-0.3-0.70.5-0.70.6-0.6
Intraocular pressure0.60.91.9-0.2-0.31.30.4-0.3-0.2-1.2-0.4-0.10.91.41.1-1.31.2-1.31.3
Delta distance traveled before/after self-admin0.00.00.20.10.00.1-0.10.10.10.1-0.10.50.00.10.00.20.00.1-0.1
Delta ambulatory time before/after self-admin0.10.10.2-0.3-0.3-0.10.3-0.3-0.4-0.3-0.30.50.30.10.20.20.20.0-0.0
Parametrial fat weight1.32.66.32.42.31.1-2.32.42.51.90.3-0.2-1.8-0.1-1.50.3-1.40.3-0.3
Pavlov. Cond. lever latency0.20.21.3-0.0-0.00.40.1-0.1-0.0-0.51.20.10.20.40.3-0.60.4-0.60.6
Pavlov. Cond. magazine entry latency1.01.31.91.01.1-0.7-1.11.11.10.91.01.0-1.4-1.2-1.41.3-1.41.3-1.3
Pavlov. Cond. change in total contacts0.70.81.61.11.20.3-1.11.21.21.3-0.3-0.2-1.0-0.3-0.90.5-0.90.5-0.5
Pavlov. Cond. index score0.20.20.80.40.50.3-0.50.50.50.9-0.9-0.5-0.30.1-0.30.2-0.30.2-0.2
Pavlov. Cond. latency score0.20.30.80.50.50.0-0.50.60.50.9-0.7-0.3-0.5-0.2-0.50.4-0.50.4-0.4
Pavlov. Cond. lever contacts0.20.21.10.30.3-0.1-0.40.40.30.7-1.1-0.2-0.3-0.2-0.40.5-0.40.5-0.5
Pavlov. Cond. magazine entry number0.00.00.1-0.1-0.2-0.30.2-0.2-0.2-0.30.30.40.1-0.2-0.00.1-0.00.1-0.1
Pavlov. Cond. intertrial magazine entries0.40.51.2-0.3-0.50.90.3-0.4-0.3-0.3-0.3-0.50.81.10.9-1.10.9-1.11.1
Pavlov. Cond. lever-magazine prob. diff.0.20.21.00.40.40.2-0.40.50.50.9-1.0-0.4-0.30.0-0.30.2-0.30.2-0.2
Pavlov. Cond. response bias0.10.20.60.30.40.3-0.40.40.40.7-0.8-0.3-0.30.1-0.30.2-0.30.2-0.2
Pavlov. Cond. lever latency0.10.20.5-0.5-0.5-0.00.4-0.5-0.6-0.7-0.1-0.60.30.10.4-0.30.4-0.30.3
Pavlov. Cond. magazine entry latency1.72.05.1-0.0-0.0-2.30.2-0.00.10.01.91.8-0.8-2.1-1.22.0-1.32.0-2.0
Pavlov. Cond. change in total contacts0.71.01.80.70.7-0.9-0.60.70.80.80.91.3-1.0-1.2-1.11.2-1.21.2-1.2
Pavlov. Cond. index score0.60.81.50.30.3-1.1-0.20.40.50.60.91.2-0.7-1.2-0.91.2-1.01.2-1.2
Pavlov. Cond. latency score0.50.61.10.30.3-0.9-0.30.40.50.60.61.0-0.6-1.0-0.81.0-0.91.0-1.0
Pavlov. Cond. lever contacts0.00.10.30.20.20.3-0.10.20.30.3-0.5-0.00.10.30.1-0.20.1-0.20.2
Pavlov. Cond. magazine entry number2.02.46.50.10.12.5-0.20.0-0.2-0.1-1.6-2.10.82.31.3-2.21.4-2.22.2
Pavlov. Cond. intertrial magazine entries0.30.41.40.10.21.2-0.30.10.1-0.3-0.6-0.60.10.90.4-1.00.5-1.01.0
Pavlov. Cond. lever-magazine prob. diff.0.70.91.90.20.2-1.4-0.10.20.40.40.91.2-0.6-1.3-0.91.3-1.01.3-1.3
Pavlov. Cond. response bias0.30.41.00.30.3-0.8-0.10.40.50.30.51.0-0.4-0.8-0.60.9-0.60.9-0.9
Time in closed arm before self-admin0.30.31.40.60.60.1-0.50.50.60.20.81.2-0.6-0.3-0.50.2-0.4-0.00.1
Time in closed arm after self-admin0.30.30.8-0.5-0.5-0.10.6-0.8-0.9-0.90.70.40.50.20.5-0.40.5-0.30.2
Time in open arm before self-admin0.30.41.6-0.7-0.7-0.20.6-0.7-0.8-0.3-0.6-1.20.60.20.5-0.60.4-0.40.4
Time in open arm after self-admin0.10.10.9-0.2-0.20.20.10.00.1-0.1-0.3-0.90.30.30.2-0.50.2-0.50.5
Bone: periosteal estimation0.20.42.30.60.60.5-0.80.60.51.5-0.8-0.1-0.50.3-0.50.2-0.50.1-0.1
Bone: periosteal perimeter0.40.61.50.90.90.0-1.00.90.71.2-0.20.0-0.9-0.4-0.90.7-0.90.6-0.6
Bone: post-yield work7.610.415.63.23.2-1.3-3.33.23.13.52.23.0-3.8-2.8-3.93.4-3.93.4-3.4
Progressive ratio test 1 active lever presses0.30.41.50.70.71.2-0.70.50.40.4-0.2-0.4-0.20.80.1-0.60.2-0.60.6
Progressive ratio test 1 breakpoint0.30.31.40.50.51.2-0.50.30.30.3-0.4-0.5-0.00.90.2-0.70.3-0.70.7
Progressive ratio test 1 inactive lever presses0.20.20.50.70.70.6-0.60.60.70.50.0-0.2-0.40.2-0.2-0.3-0.2-0.30.3
Progressive ratio test 2 active lever presses0.80.92.61.31.31.6-1.41.21.11.0-0.2-0.4-0.60.9-0.3-0.5-0.2-0.60.6
Progressive ratio test 2 breakpoint1.01.14.41.11.12.1-1.21.00.90.9-0.8-1.0-0.31.50.1-1.00.2-1.01.0
Progressive ratio test 2 inactive lever presses3.03.57.32.72.72.5-2.72.62.52.5-0.4-1.0-1.61.1-1.1-0.7-1.0-0.60.6
Incentive Sensitization - Responses0.10.10.30.50.50.4-0.50.50.40.30.30.2-0.30.2-0.20.0-0.2-0.00.0
Incentive Sensitization - Breakpoint0.20.20.40.70.70.6-0.70.60.50.50.20.2-0.40.3-0.2-0.0-0.2-0.10.1
Sum of active levers in priming session hrs 5-63.02.96.4-1.7-1.71.01.5-1.3-1.4-1.2-2.5-1.72.01.72.0-1.81.9-1.61.6
Progressive ratio3.74.39.40.60.5-2.7-0.50.80.70.52.42.5-1.7-2.9-2.03.0-2.13.1-3.1
Food seeking constrained by brief footshock0.10.20.5-0.7-0.6-0.70.5-0.4-0.1-0.3-0.40.50.1-0.6-0.00.2-0.10.3-0.3
Seeking ratio, punishment vs. effort2.43.06.4-0.7-0.52.10.4-0.7-0.5-0.3-2.4-1.91.42.31.6-2.51.7-2.52.5
Retroperitoneal fat weight2.06.514.53.23.23.8-3.43.33.33.5-2.1-2.1-1.72.1-0.9-1.3-0.7-1.41.5
Reaction time number correct0.40.64.0-0.8-0.8-0.00.9-0.6-0.60.1-2.0-0.60.90.50.8-0.30.8-0.30.3
Reaction time mean minus median0.81.13.9-0.1-0.2-1.50.3-0.1-0.0-0.51.32.0-0.2-1.2-0.61.5-0.61.5-1.5
Reaction time mean minus median AUC0.40.52.0-0.4-0.5-1.00.6-0.3-0.3-0.80.41.40.4-0.50.10.90.00.9-0.9
Reaction time num false alarms0.71.01.5-1.0-1.10.51.0-1.1-1.0-0.9-0.8-0.81.21.01.2-1.01.2-1.01.0
Reaction time num false alarms AUC0.81.02.1-1.4-1.4-0.31.4-1.4-1.3-1.3-0.6-0.51.20.41.1-0.61.1-0.50.5
Reaction time trials correct on left0.40.64.0-0.8-0.8-0.00.9-0.6-0.60.1-2.0-0.60.90.50.8-0.30.8-0.30.3
Reaction time trials on left0.50.74.3-1.0-0.9-0.11.0-0.8-0.7-0.1-2.1-0.61.10.60.9-0.30.9-0.30.4
Reaction time mean0.50.73.00.70.6-0.3-0.60.60.6-0.11.31.7-0.7-0.5-0.70.8-0.70.9-0.9
Reaction time mean AUC0.50.72.50.80.7-0.2-0.80.70.70.11.11.6-0.8-0.5-0.80.9-0.80.9-0.9
Median of all reaction times0.60.82.70.90.8-0.2-0.90.70.70.11.41.6-0.9-0.6-0.90.8-0.90.8-0.8
Reaction time omissions0.40.61.6-0.8-0.9-1.21.0-0.8-0.8-0.90.30.90.6-0.70.30.70.20.7-0.7
Reaction time false alarm rate0.40.61.4-0.9-1.0-0.00.9-1.1-1.0-1.20.2-0.50.80.40.8-0.70.8-0.60.5
Reaction time premature initiation rate0.91.22.7-1.6-1.6-1.61.6-1.6-1.6-1.50.40.30.8-0.90.50.30.40.2-0.2
Reaction time premature initiations1.52.25.0-2.2-2.2-1.62.2-2.1-2.0-1.7-1.0-0.01.5-0.51.1-0.01.0-0.10.1
Std. dev. reaction times0.50.72.70.20.1-0.8-0.00.10.2-0.41.41.6-0.3-0.8-0.51.1-0.51.1-1.1
Reaction time trials completed0.50.74.3-1.0-0.9-0.11.0-0.8-0.7-0.1-2.1-0.61.10.60.9-0.30.9-0.30.4
Reaction time trials AUC0.40.63.8-0.8-0.8-0.00.8-0.6-0.50.1-1.9-0.50.90.50.8-0.20.7-0.30.3
Run reversals in cocaine runway, females2.01.96.80.30.3-1.7-0.20.30.50.02.62.5-1.0-1.9-1.21.5-1.31.5-1.5
Run reversals in cocaine runway, males0.80.81.3-0.6-0.70.30.9-0.9-1.1-1.10.2-0.51.10.81.1-1.01.1-1.01.0
Latency to leave start box in cocaine runway1.01.11.80.91.0-0.4-1.11.21.11.20.41.1-1.3-0.9-1.30.9-1.31.0-1.0
Latency to leave start box in cocaine runway, F0.70.71.30.80.9-0.4-0.80.90.80.90.61.1-1.0-0.8-1.10.7-1.10.7-0.7
Latency to leave start box in cocaine runway, M0.10.10.80.00.00.0-0.20.30.20.3-0.9-0.0-0.2-0.1-0.20.3-0.20.3-0.3
Std. dev. time between licks in bursts1.51.83.2-1.4-1.40.01.6-1.4-1.6-1.8-1.0-1.21.60.71.5-1.21.5-1.21.2
Total sessions with >9 infusions0.40.40.80.90.90.5-0.90.80.90.80.30.2-0.70.0-0.50.4-0.50.2-0.1
Short access day 1 total inactive lever presses0.91.02.11.51.51.3-1.41.41.41.3-0.50.1-0.80.6-0.6-0.1-0.5-0.10.1
Short access day 10 total inactive lever presses0.70.81.41.11.11.1-1.21.21.21.2-1.0-0.7-0.60.6-0.5-0.6-0.4-0.50.5
Short access day 1 total infusions1.41.43.21.81.80.7-1.71.61.71.60.60.2-1.4-0.2-1.20.3-1.10.2-0.2
Short access day 10 total infusions3.33.76.72.12.1-0.6-1.92.01.91.72.61.5-2.2-1.6-2.22.0-2.11.8-1.8
Short access total infusions1.21.42.51.41.4-0.2-1.31.31.31.21.60.7-1.4-0.8-1.31.1-1.21.0-1.0
Short access day 1 locomotion1.71.83.21.81.80.4-1.71.81.81.50.90.8-1.5-0.4-1.31.2-1.21.1-1.0
Short access day 10 total locomotion1.01.11.81.31.3-0.0-1.21.21.30.91.11.2-1.2-0.6-1.10.7-1.00.7-0.6
Short access total locomotion0.90.91.41.21.2-0.1-1.01.11.10.91.00.8-1.1-0.7-1.01.0-1.00.8-0.8
One hour access (0.3 mA shock)2.52.96.82.42.42.6-2.52.42.32.1-0.4-0.7-1.31.4-0.8-0.8-0.6-0.80.8
Compulsive drug intake2.42.55.5-2.3-2.3-1.42.3-2.2-2.2-2.3-0.10.61.7-0.21.3-0.41.2-0.40.4
One hour access (shock baseline)3.23.78.72.72.73.0-2.72.52.42.4-0.7-1.2-1.41.6-0.8-1.1-0.6-1.11.1
Social response proportion0.90.94.20.30.3-1.30.10.20.0-0.62.01.7-0.5-1.3-0.61.0-0.71.0-0.9
Social responses0.20.31.0-0.4-0.5-0.40.7-0.6-0.5-1.00.41.00.6-0.00.50.30.40.3-0.3
Social time0.20.20.8-0.4-0.3-0.80.5-0.3-0.3-0.20.30.90.2-0.50.00.6-0.00.6-0.6
Soleus weight1.33.713.31.21.23.7-1.31.31.40.8-1.7-2.40.22.80.9-2.41.1-2.42.4
Bone: stiffness1.72.75.50.70.7-1.9-0.70.70.51.31.41.8-1.5-2.2-1.92.3-2.02.3-2.3
Tibialis anterior weight4.013.631.8-5.6-5.5-2.85.4-5.5-5.4-3.7-1.8-0.94.40.23.4-0.63.0-0.60.6
Time to tail flick, vehicle, before self-admin2.52.55.40.90.9-1.6-0.70.80.90.62.31.3-1.5-2.0-1.62.1-1.62.3-2.3
Time to tail flick, vehicle, after self-admin0.80.83.0-0.7-0.8-1.70.8-0.7-0.7-0.71.00.90.1-1.3-0.31.1-0.41.0-1.0
Time to tail flick, test, before self-admin2.12.12.91.31.4-0.8-1.21.41.51.31.11.4-1.6-1.4-1.61.7-1.61.7-1.7
Time to tail flick, test, after self-admin0.10.10.5-0.3-0.4-0.30.3-0.2-0.3-0.70.20.30.2-0.20.2-0.00.20.2-0.2
Delta time to tail flick, vehicle, before/after SA0.30.30.9-0.9-0.9-0.60.8-0.7-0.8-0.6-0.60.10.6-0.10.40.00.3-0.10.2
Delta time to tail flick, test, before/after SA3.73.36.0-2.2-2.30.22.1-2.2-2.3-2.5-0.9-1.12.21.22.1-1.62.1-1.41.3
Tibia length0.82.49.3-1.4-1.30.71.2-1.3-1.4-0.5-3.1-2.11.61.41.6-1.31.5-1.21.2
Ambulatory time before self-admin0.30.30.70.50.5-0.4-0.40.70.80.60.20.5-0.6-0.6-0.60.5-0.70.6-0.6
Ambulatory time after self-admin1.51.73.11.51.50.0-1.51.81.61.70.61.2-1.4-0.7-1.41.0-1.41.0-1.0
Bone: tissue strength0.60.62.41.01.00.5-1.11.01.01.5-0.30.4-0.70.1-0.70.3-0.80.3-0.3
Total heroin consumption1.41.74.0-1.8-1.8-2.01.9-1.6-1.5-1.80.90.30.9-1.10.60.60.40.6-0.6
Bone: trabecular number2.23.45.31.41.4-1.5-1.31.41.21.71.51.9-1.9-2.1-2.22.3-2.32.3-2.3
Bone: trabecular spacing0.91.22.2-0.9-1.00.80.8-0.9-0.8-0.9-1.2-1.51.01.11.2-1.31.2-1.31.3
Bone: trabecular thickness1.92.33.31.71.8-0.1-1.81.71.71.80.61.4-1.8-0.9-1.81.3-1.81.3-1.3
Bone: trabecular tissue density2.53.510.40.80.83.1-1.00.80.71.0-2.7-3.20.32.50.9-2.31.1-2.32.3
Water consumed over 24 hours0.50.61.6-0.3-0.3-1.10.2-0.4-0.40.20.51.3-0.2-0.9-0.51.3-0.61.2-1.3
Number of responses in last shaping day0.30.30.90.30.30.9-0.30.30.20.2-0.9-0.60.10.70.2-0.70.2-0.70.7