Hub : Genes

Cpd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Cpd 0.05 0.04 2.6e-06 0.06 0.05 0.05 0.05 9.5e-07 3.3e-06 1.3e-06 1.5e-06
2 PL gene expression Cpd 0.04 0.03 2.7e-05 0.04 0.04 0.04 0.04 1.2e-05 5.8e-05 7.7e-05 1.8e-05
3 Liver gene expression Cpd 0.26 0.12 0.0e+00 0.15 0.17 0.17 0.16 1.8e-16 4.9e-18 5.2e-18 1.7e-17
4 Brain mRNA stability Cpd 0.05 0.04 1.6e-06 0.07 0.05 0.04 0.04 9.2e-07 1.6e-05 4.5e-05 6.3e-05
5 NAcc mRNA stability Cpd 0.02 0.02 1.3e-04 0.02 0.02 0.01 0.01 4.3e-04 1.0e-03 4.0e-03 2.3e-03
6 pVTA mRNA stability Cpd 0.03 0.02 1.0e-03 0.06 0.03 0.05 0.05 1.0e-05 3.9e-03 1.3e-04 3.5e-05
7 Adipose mRNA stability Cpd 0.08 0.05 7.7e-09 0.07 0.06 0.06 0.06 4.1e-08 3.8e-07 3.4e-07 1.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density2.03.64.32.12.0-2.01.91.91.71.7
Area under the delay curve0.60.91.2-1.0-0.91.0-1.1-1.0-1.1-0.3
BMI with tail0.82.95.20.91.7-1.81.52.02.31.3
BMI without tail1.15.98.41.92.5-2.62.42.92.42.2
Body weight3.113.718.03.54.0-4.23.93.83.03.3
Weight adjusted by age0.10.20.7-0.4-0.20.4-0.30.20.80.1
Bone surface0.91.82.41.11.4-1.41.21.61.51.1
Bone volume0.91.82.31.21.3-1.41.31.51.41.1
Breakpoint value in progressive ratio session1.73.05.11.82.0-2.31.81.41.01.6
Number of licking bursts0.20.61.3-0.4-0.80.8-1.2-0.8-0.6-0.6
Context. condit. distance diff. score0.60.71.11.00.7-0.70.71.00.71.0
Locomotion velocity, session 11.92.12.71.51.5-1.61.41.31.21.6
Locomotion distance, session 10.10.10.20.30.4-0.50.3-0.10.10.4
Locomotion velocity, session 20.10.10.40.50.4-0.10.2-0.00.30.6
Locomotion distance, session 20.71.01.31.01.1-1.10.90.80.91.1
Locomotion velocity, session 31.92.14.3-1.7-1.31.0-1.5-1.3-2.1-1.2
Locomotion distance, session 30.50.51.4-1.2-0.60.2-0.7-0.5-1.0-0.6
Stereotopy head waving bouts, day 30.20.30.50.50.5-0.70.60.6-0.00.4
Stereotopy head waving duration, day 30.20.30.4-0.4-0.50.6-0.5-0.4-0.5-0.6
Locomotion velocity, session 70.20.20.7-0.5-0.0-0.40.30.60.8-0.0
Locomotion distance, session 70.10.10.5-0.20.1-0.40.10.50.70.2
Stereotopy head waving bouts, day 70.70.81.20.70.8-1.01.01.10.80.9
Stereotopy head waving duration, day 70.60.81.10.70.8-1.11.01.00.60.9
Locomotion velocity, session 80.00.00.0-0.1-0.2-0.10.0-0.0-0.10.1
Locomotion distance, session 80.71.12.01.11.1-1.00.80.90.61.4
Degree of sensitization distance2.02.24.51.61.3-0.91.31.52.11.3
Degree of sensitization stereotypy1.01.11.31.00.9-1.11.11.11.01.1
Conditioned locomotion0.50.61.3-0.7-0.70.6-0.7-0.8-1.1-0.7
Cocaine response after cond. corrected1.21.83.21.31.1-1.11.51.21.81.3
Cocaine response after cond. not corrected1.72.43.91.51.4-1.41.71.42.01.4
Cocaine response before conditioning0.20.20.40.40.6-0.60.50.40.30.5
Saline control response0.40.51.1-0.7-0.71.0-1.1-0.4-0.1-0.6
Bone: connectivity density3.65.76.42.42.5-2.52.42.52.32.1
Bone: cortical apparent density0.20.30.9-0.3-0.70.6-0.3-0.3-0.5-0.9
Bone: cortical area1.72.84.6-2.1-1.81.6-1.8-1.4-1.3-1.7
Bone: cortical porosity0.30.40.70.40.4-0.60.70.80.50.7
Bone: cortical porosity0.10.10.20.10.1-0.30.30.50.30.4
Bone: cortical thickness1.83.14.1-2.0-1.71.6-1.8-1.5-1.9-1.7
Bone: cortical thickness0.10.10.3-0.5-0.30.4-0.3-0.40.2-0.1
Bone: cortical tissue density0.10.20.6-0.1-0.50.4-0.1-0.2-0.2-0.7
Condit. Reinf. active minus inactive responses0.20.30.80.20.5-0.60.3-0.1-0.90.4
Condit. Reinf. active-inactive response ratio0.10.10.3-0.00.4-0.50.2-0.1-0.40.4
Condit. Reinf. active responses0.30.40.70.80.9-0.80.70.3-0.10.8
Condit. Reinf. inactive responses0.10.20.60.70.30.10.30.30.70.1
Incentive salience index mean0.30.40.80.40.8-0.90.60.1-0.40.9
Condit. Reinf. lever presses1.01.52.50.91.3-1.51.30.90.81.6
Condit. Reinf. active minus inactive responses0.10.20.60.00.00.1-0.4-0.6-0.8-0.1
Condit. Reinf. active-inactive response ratio0.20.21.0-0.0-0.10.2-0.4-0.7-1.0-0.2
Condit. Reinf. active responses0.10.20.3-0.4-0.30.4-0.6-0.5-0.5-0.4
Condit. Reinf. inactive responses0.10.20.4-0.6-0.40.4-0.40.10.4-0.5
Condit. Reinf. lever presses1.72.53.7-1.4-1.31.3-1.4-1.8-1.9-1.6
Condit. Reinf. lever reinforcers received0.30.40.7-0.5-0.40.5-0.7-0.7-0.8-0.5
Conditioned reinforcement - actives0.10.21.00.50.5-0.20.20.00.41.0
Conditioned reinforcement - inactives0.00.10.2-0.2-0.20.5-0.4-0.20.30.2
Conditioned locomotion0.10.10.4-0.5-0.20.3-0.3-0.10.3-0.7
Patch foraging indifference point 0 sec0.10.20.9-0.30.1-0.2-0.3-0.3-1.0-0.1
Patch foraging indifference point AUC1.33.23.8-1.7-1.91.9-1.8-2.0-1.4-1.8
Delay disc. indifference point, 0s delay0.70.82.3-0.7-0.50.7-1.1-1.0-1.50.5
Delay disc. indifference point, 16s delay0.60.91.4-0.9-1.11.1-0.8-1.2-0.8-0.7
Delay disc. indifference point, 2s delay1.71.93.1-1.0-1.21.4-1.6-1.8-1.6-0.5
Delay disc. indifference point, 24s delay0.20.31.8-0.1-0.10.2-0.10.71.3-0.0
Delay disc. indifference point, 4s delay0.10.10.30.60.2-0.0-0.4-0.1-0.60.3
Delay disc. indifference point, 8s delay0.10.10.3-0.5-0.50.5-0.4-0.2-0.2-0.0
Indifference point function ln k0.72.33.31.61.8-1.61.51.40.61.7
Indifference point function log k0.72.33.31.61.8-1.61.51.40.61.7
Patch foraging total patch changes 0 sec0.10.10.5-0.4-0.10.0-0.4-0.4-0.7-0.2
Patch foraging total patch changes 12 sec0.60.81.5-1.1-0.90.7-0.9-1.0-0.5-1.2
Patch foraging total patch changes 18 sec0.51.22.0-0.9-1.00.8-1.0-1.4-1.4-1.0
Patch foraging total patch changes 24 sec0.51.73.2-1.2-1.00.8-1.2-1.6-1.8-1.1
Patch foraging total patch changes 6 sec2.84.85.9-2.2-2.02.0-2.3-2.4-2.3-2.1
Patch foraging time to switch 0 sec0.31.32.81.11.0-0.81.11.31.70.6
Patch foraging water rate 0 sec0.83.23.8-1.9-1.81.7-1.9-1.9-1.9-1.3
Patch foraging water rate 12 sec0.00.10.40.30.20.10.10.10.6-0.4
Patch foraging water rate 18 sec0.30.71.71.31.1-0.50.60.60.60.4
Patch foraging water rate 24 sec0.50.81.1-1.0-0.91.0-1.1-0.9-0.7-0.6
Patch foraging water rate 6 sec0.91.41.8-1.2-1.11.3-1.3-1.1-1.3-1.0
Seeking ratio, delayed vs. immediate footshock2.63.73.9-1.9-1.92.0-2.0-2.0-1.9-1.8
Distance traveled before self-admin2.24.75.5-2.0-2.22.3-2.0-2.3-2.1-2.3
Distance traveled after self-admin0.20.30.5-0.6-0.60.3-0.7-0.5-0.2-0.6
Extensor digitorum longus weight0.52.24.01.01.3-1.71.52.01.61.0
Bone: elastic displacement1.21.53.2-0.9-1.11.1-1.2-1.4-1.8-0.8
Bone: elastic work3.95.111.5-2.4-1.81.6-2.3-2.3-3.4-1.4
Bone: endosteal estimation0.41.01.5-1.2-1.21.0-1.1-0.9-0.3-1.0
Bone: endosteal perimeter0.20.60.9-0.9-0.90.9-0.8-0.50.0-0.7
Epididymis fat weight4.824.528.05.34.9-4.64.95.25.14.6
Delta time in closed arm before/after self-admin1.61.51.9-0.7-1.31.2-1.3-1.2-1.3-1.4
Delta time in open arm before/after self-admin2.12.53.61.11.6-1.71.71.81.91.1
Diff in mean of infusions in LGA sessions0.91.52.51.51.6-1.51.01.00.61.2
Delay discount exponential model param0.40.50.80.70.7-0.80.90.80.70.1
Extinction: sum of active levers before priming0.50.81.40.70.8-1.21.20.60.80.8
Active lever presses in extinction session 61.11.12.31.01.1-1.01.40.50.51.5
Bone: final force0.30.51.9-1.4-0.3-0.1-0.6-0.3-0.9-0.4
Bone: final moment0.30.51.9-1.4-0.4-0.1-0.7-0.4-1.0-0.4
Food consumed during 24 hour testing period0.10.10.30.20.4-0.50.50.30.10.4
Glucose1.62.53.1-1.6-1.81.7-1.6-1.3-1.4-1.6
Heart weight1.72.83.91.41.8-2.01.71.61.51.6
Delay discount hyperbolic model param0.50.71.10.80.8-0.91.00.91.00.1
Intermittent access intake day 1-15 change0.10.52.3-0.3-0.50.8-0.6-0.4-0.0-1.5
Intermittent access intake escalation0.10.52.3-0.3-0.30.7-0.5-0.30.0-1.5
Intermittent access intake escalation 20.61.02.0-0.7-0.91.2-1.2-0.9-0.4-1.4
Intermitt. access day 1 inactive lever presses0.11.43.7-1.4-1.11.1-1.1-0.8-0.6-1.9
Intermitt. access day 15 inactive lever presses0.63.03.9-1.4-1.92.0-1.5-1.7-1.6-2.0
Intermitt. access escalation Index0.92.85.02.22.1-1.71.51.11.01.7
Intermittent access day 1 total infusions0.00.00.0-0.1-0.10.20.0-0.1-0.00.0
Intermittent access day 15 total infusions0.00.10.5-0.2-0.10.4-0.2-0.10.1-0.7
Intermittent access terminal intake (last 3 days)0.00.10.20.40.30.00.10.20.4-0.1
Intermittent access total infusions0.20.20.4-0.5-0.50.6-0.3-0.5-0.2-0.6
Intermittent access day 1 locomotion0.20.30.8-0.9-0.60.5-0.6-0.4-0.1-0.7
Intermittent access day 15 total locomotion0.10.30.5-0.7-0.60.5-0.30.10.6-0.7
Intermittent access total locomotion0.20.20.5-0.7-0.50.4-0.30.00.5-0.7
Intermittent access standard deviation0.31.73.5-1.3-1.41.5-0.8-1.1-0.7-1.9
Left kidney weight0.10.41.00.50.9-1.00.70.60.20.1
Right kidney weight0.10.91.60.81.1-1.31.11.20.50.5
Cocaine induced anxiety0.10.20.70.1-0.20.2-0.2-0.5-0.8-0.2
Post-drug Anxiety1.31.53.21.81.4-1.41.40.80.31.1
Baseline Anxiety0.71.21.91.41.1-1.11.11.00.91.1
Tail length1.26.48.22.82.6-2.92.72.61.12.6
Length with tail1.77.410.43.22.9-3.13.02.51.32.6
Length without tail0.63.25.02.22.0-2.02.01.40.71.6
Times rat made contact with spout0.20.20.6-0.6-0.1-0.20.80.10.4-0.1
Lifetime Intake0.10.10.3-0.4-0.40.30.0-0.2-0.1-0.6
Liver weight, left6.110.511.93.53.3-3.33.33.42.83.3
Liver weight, right6.912.113.93.73.5-3.73.73.62.43.5
Locomotor activity0.10.10.5-0.0-0.10.0-0.1-0.7-0.30.1
Locomotor testing distance0.10.41.1-0.4-0.50.7-0.7-1.0-0.2-0.1
Locomotor testing rearing0.10.40.8-0.5-0.80.9-0.6-0.90.1-0.4
Locomotion in novel chamber3.04.17.2-2.0-2.02.1-2.0-1.6-1.6-2.7
Locomotion in novel chamber post-restriction0.10.30.90.20.4-0.50.50.91.0-0.0
Fecal boli incidents, locomotor time 10.41.12.41.01.1-0.80.71.21.60.4
Change in fecal boli incidents, locomotor task0.20.20.6-0.4-0.40.2-0.6-0.2-0.80.3
Time >=10cm from walls, locomotor time 10.20.20.9-1.0-0.0-0.1-0.30.30.30.4
Bouts of movement, locomotor time 10.20.30.4-0.6-0.40.6-0.6-0.4-0.40.3
Total resting periods, locomotor time 10.20.30.5-0.6-0.50.7-0.7-0.2-0.20.3
Rest time, locomotor task time 10.20.30.6-0.3-0.50.7-0.70.30.1-0.7
Distance moved, locomotor task time 10.00.10.4-0.10.0-0.2-0.0-0.5-0.70.2
Vertical activity count, locomotor time 10.00.30.50.50.7-0.70.2-0.0-0.60.7
Time >=10cm from walls, locomotor time 20.10.31.0-1.00.2-0.3-0.80.6-0.4-0.1
Bouts of movement, locomotor time 20.10.41.00.1-0.30.5-0.7-0.9-1.00.1
Total resting periods, locomotor time 20.00.10.30.2-0.00.1-0.2-0.5-0.50.4
Rest time, locomotor task time 20.00.10.20.3-0.30.40.0-0.10.40.1
Distance moved, locomotor task time 20.20.20.6-0.3-0.40.4-0.4-0.2-0.6-0.8
Vertical activity count, locomotor time 20.20.41.5-0.1-0.10.2-0.7-0.3-1.2-0.7
Light reinforcement 10.00.00.00.2-0.00.00.1-0.0-0.2-0.2
Light reinforcement 20.20.51.0-0.8-0.80.6-0.6-0.6-0.7-1.0
Bone: marrow area0.41.01.6-1.3-1.21.0-1.1-0.9-0.3-1.0
Bone: maximum diameter1.02.13.7-1.9-1.61.5-1.5-1.1-0.7-1.5
Bone: maximum force0.61.23.3-1.8-1.00.5-1.1-0.9-1.1-1.0
Bone: maximum moment0.71.33.2-1.8-1.00.6-1.1-1.0-1.2-1.0
Mean time between licks in bursts0.10.81.60.80.7-0.70.91.11.20.9
Mean num. licks in bursts0.40.92.90.00.8-1.01.70.91.00.5
Cd content in liver1.41.52.1-0.4-1.41.3-1.4-1.1-1.4-1.2
Co content in liver0.30.30.6-0.8-0.50.4-0.3-0.5-0.7-0.5
Cu content in liver1.21.42.0-1.3-1.21.3-1.0-1.4-0.9-1.0
Fe content in liver0.91.11.41.10.9-0.81.21.01.11.0
K content in liver0.60.61.20.51.0-1.11.00.60.30.7
Mg content in liver0.30.30.5-0.6-0.30.3-0.7-0.5-0.7-0.5
Mn content in liver0.10.10.2-0.2-0.20.3-0.4-0.4-0.3-0.3
Na content in liver0.00.10.1-0.2-0.10.30.3-0.3-0.0-0.1
Rb content in liver0.00.00.10.10.2-0.0-0.30.1-0.10.2
Se content in liver0.80.93.9-0.6-0.40.4-1.0-0.8-2.0-0.2
Sr content in liver0.30.30.80.30.3-0.30.60.50.90.2
Zn content in liver0.20.30.40.60.7-0.50.30.50.20.6
Bone: minimum diameter0.40.81.5-1.1-1.21.0-0.8-0.7-0.1-1.0
Time in familiar zone, hab. session 10.50.60.9-0.9-0.90.6-0.7-0.6-0.6-0.9
Time in novel zone, hab. session 10.10.10.40.60.4-0.10.20.20.40.5
Total zone transitions, hab. session 10.10.10.30.1-0.10.3-0.3-0.4-0.5-0.0
Total locomotion distance, hab. session 10.10.10.30.60.2-0.10.1-0.1-0.40.6
Locomotion velocity, hab. session 10.10.10.50.2-0.00.1-0.2-0.4-0.70.4
Time in familiar zone, hab. session 20.10.10.2-0.3-0.50.3-0.2-0.3-0.1-0.2
Time in novel zone, hab. session 20.10.20.5-0.3-0.10.3-0.5-0.3-0.7-0.3
Total zone transitions, hab. session 20.81.01.71.31.2-1.00.90.70.31.1
Total locomotion distance, hab. session 20.40.51.01.00.9-0.80.60.1-0.30.8
Locomotion velocity, hab. session 20.30.40.80.90.8-0.70.50.0-0.40.8
Novel to familiar place preference ratio0.10.20.9-0.20.00.2-0.00.21.0-0.4
Novelty place preference0.20.21.10.10.3-0.10.20.41.10.0
Time in novel zone, NPP test0.20.31.20.30.5-0.30.40.61.10.2
Total zone transitions, NPP test0.10.10.30.50.4-0.40.30.0-0.20.3
Total locomotion distance, NPP test0.30.41.4-0.0-0.30.5-0.6-1.0-1.2-0.2
Locomotion velocity, NPP test0.50.81.6-0.3-0.60.8-0.9-1.3-1.3-0.5
Intraocular pressure1.42.33.5-1.4-1.71.9-1.5-1.4-0.8-1.7
Delta distance traveled before/after self-admin2.42.63.61.31.6-1.91.51.61.71.6
Delta ambulatory time before/after self-admin1.32.22.81.21.5-1.71.41.51.61.6
Parametrial fat weight6.916.417.94.24.1-3.94.14.14.23.7
Pavlov. Cond. lever latency0.10.10.4-0.1-0.40.5-0.4-0.20.0-0.7
Pavlov. Cond. magazine entry latency0.60.71.70.60.8-1.31.00.60.00.9
Pavlov. Cond. change in total contacts0.30.30.5-0.6-0.70.4-0.4-0.6-0.5-0.5
Pavlov. Cond. index score0.30.41.10.30.6-1.10.80.4-0.10.8
Pavlov. Cond. latency score0.50.61.30.40.7-1.20.90.60.01.0
Pavlov. Cond. lever contacts0.10.20.40.10.3-0.60.40.20.00.6
Pavlov. Cond. magazine entry number0.20.20.6-0.2-0.20.8-0.6-0.10.4-0.3
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.1-0.30.7-0.5-0.6-0.4-0.5
Pavlov. Cond. lever-magazine prob. diff.0.30.30.90.20.5-0.90.70.2-0.30.7
Pavlov. Cond. response bias0.40.51.00.50.6-1.00.90.4-0.10.7
Pavlov. Cond. lever latency2.02.83.91.41.5-1.51.52.01.91.8
Pavlov. Cond. magazine entry latency0.10.10.20.10.1-0.40.50.1-0.5-0.2
Pavlov. Cond. change in total contacts0.81.92.4-1.5-1.21.2-1.3-1.5-1.6-1.2
Pavlov. Cond. index score1.42.22.8-1.3-1.51.3-1.2-1.7-1.7-1.6
Pavlov. Cond. latency score1.72.73.4-1.5-1.61.5-1.4-1.8-1.8-1.8
Pavlov. Cond. lever contacts0.91.31.9-0.9-1.01.0-0.9-1.4-1.4-1.2
Pavlov. Cond. magazine entry number0.00.00.10.20.10.2-0.20.10.20.4
Pavlov. Cond. intertrial magazine entries0.20.41.10.80.7-0.40.30.50.51.0
Pavlov. Cond. lever-magazine prob. diff.1.21.82.4-1.2-1.31.2-1.1-1.5-1.5-1.5
Pavlov. Cond. response bias0.71.01.9-0.8-0.90.8-0.7-1.1-1.4-1.1
Time in closed arm before self-admin0.91.64.41.11.4-1.00.90.81.12.1
Time in closed arm after self-admin0.80.91.7-0.5-0.91.3-1.1-1.2-0.8-0.3
Time in open arm before self-admin1.92.34.4-1.5-1.71.5-1.3-1.0-1.1-2.1
Time in open arm after self-admin0.40.51.1-0.5-0.0-0.40.60.90.8-1.0
Bone: periosteal estimation1.02.44.0-2.0-1.71.5-1.7-1.3-0.9-1.5
Bone: periosteal perimeter0.71.42.4-1.5-1.31.2-1.3-1.0-0.7-1.1
Bone: post-yield work0.20.40.50.40.5-0.70.70.70.70.5
Progressive ratio test 1 active lever presses0.50.91.4-0.9-0.90.8-0.8-1.2-1.1-0.8
Progressive ratio test 1 breakpoint0.50.91.5-0.9-0.90.8-0.8-1.2-1.1-0.8
Progressive ratio test 1 inactive lever presses2.05.16.1-2.5-2.32.2-2.3-2.4-1.9-2.2
Progressive ratio test 2 active lever presses0.71.01.9-1.1-1.01.1-0.9-1.4-0.9-0.6
Progressive ratio test 2 breakpoint0.71.01.7-1.0-0.91.1-0.9-1.3-0.9-0.5
Progressive ratio test 2 inactive lever presses0.41.31.9-1.3-1.11.3-0.8-1.3-0.7-1.4
Incentive Sensitization - Responses0.00.10.2-0.2-0.10.5-0.2-0.40.2-0.0
Incentive Sensitization - Breakpoint0.00.10.2-0.1-0.00.4-0.1-0.30.20.1
Sum of active levers in priming session hrs 5-63.23.05.21.51.9-2.32.01.51.11.7
Progressive ratio0.00.10.5-0.7-0.10.4-0.30.10.4-0.4
Food seeking constrained by brief footshock0.00.00.10.20.1-0.10.2-0.30.10.1
Seeking ratio, punishment vs. effort0.10.10.40.2-0.50.2-0.2-0.6-0.4-0.2
Retroperitoneal fat weight0.41.83.92.01.2-0.91.41.21.60.6
Reaction time number correct0.10.41.20.50.7-0.30.40.51.10.8
Reaction time mean minus median0.10.51.41.20.7-0.40.90.60.80.2
Reaction time mean minus median AUC0.31.72.91.71.2-0.91.51.31.70.5
Reaction time num false alarms3.05.18.9-2.3-2.41.9-2.3-2.1-3.0-1.4
Reaction time num false alarms AUC2.35.49.2-2.6-2.41.9-2.4-2.1-3.0-1.4
Reaction time trials correct on left0.10.41.20.50.7-0.30.40.51.10.8
Reaction time trials on left0.10.51.20.50.7-0.40.40.61.10.8
Reaction time mean0.40.91.81.20.7-0.41.00.81.30.6
Reaction time mean AUC0.20.51.41.00.5-0.20.80.71.20.3
Median of all reaction times0.30.41.40.80.3-0.10.70.41.20.5
Reaction time omissions1.62.53.51.91.8-1.61.71.81.21.0
Reaction time false alarm rate3.54.99.3-2.4-2.31.7-2.2-2.0-3.1-1.4
Reaction time premature initiation rate0.20.40.90.91.0-0.60.50.20.20.3
Reaction time premature initiations0.20.51.31.01.2-0.60.50.40.50.5
Std. dev. reaction times0.31.01.61.31.0-0.71.21.11.20.5
Reaction time trials completed0.10.51.20.50.7-0.40.40.61.10.8
Reaction time trials AUC0.10.31.00.40.6-0.30.30.51.00.6
Run reversals in cocaine runway, females0.10.10.40.50.2-0.10.30.60.2-0.4
Run reversals in cocaine runway, males0.20.20.40.60.4-0.30.40.70.60.1
Latency to leave start box in cocaine runway0.00.00.1-0.1-0.0-0.10.1-0.2-0.30.4
Latency to leave start box in cocaine runway, F0.30.41.10.40.4-0.70.60.40.01.0
Latency to leave start box in cocaine runway, M0.30.30.7-0.4-0.40.6-0.5-0.9-0.2-0.4
Std. dev. time between licks in bursts0.20.30.6-0.7-0.60.7-0.2-0.40.8-0.4
Total sessions with >9 infusions0.10.10.4-0.5-0.40.1-0.00.10.3-0.7
Short access day 1 total inactive lever presses0.71.33.00.51.0-1.01.21.31.70.8
Short access day 10 total inactive lever presses0.11.02.0-1.4-0.90.9-1.1-0.6-0.5-1.3
Short access day 1 total infusions0.20.41.1-0.9-0.60.6-0.4-0.4-0.3-1.1
Short access day 10 total infusions0.10.10.5-0.1-0.20.00.30.0-0.0-0.7
Short access total infusions0.40.61.6-0.9-0.90.7-0.3-0.5-0.4-1.3
Short access day 1 locomotion0.81.43.2-1.6-1.20.8-0.8-0.9-0.8-1.8
Short access day 10 total locomotion0.62.43.6-1.9-1.51.2-1.4-1.5-1.4-1.8
Short access total locomotion1.92.94.7-2.2-1.81.4-1.5-1.4-1.3-2.1
One hour access (0.3 mA shock)0.10.10.2-0.1-0.10.1-0.1-0.5-0.3-0.4
Compulsive drug intake1.72.53.61.61.8-1.91.91.61.30.8
One hour access (shock baseline)0.40.91.2-0.9-1.11.1-1.1-1.1-0.8-0.6
Social response proportion3.74.76.52.12.5-2.52.12.01.32.5
Social responses1.82.34.21.41.7-1.41.31.21.42.1
Social time1.52.44.21.51.6-1.51.41.31.42.1
Soleus weight3.08.911.72.93.1-3.43.33.22.52.5
Bone: stiffness0.40.81.70.20.8-1.10.71.11.30.6
Tibialis anterior weight2.48.310.12.42.9-3.12.93.23.02.8
Time to tail flick, vehicle, before self-admin0.10.20.80.10.2-0.40.5-0.0-0.10.9
Time to tail flick, vehicle, after self-admin0.10.20.60.20.1-0.1-0.3-0.7-0.80.2
Time to tail flick, test, before self-admin0.30.31.8-0.10.1-0.40.30.10.41.4
Time to tail flick, test, after self-admin0.00.00.10.40.20.1-0.1-0.1-0.2-0.1
Delta time to tail flick, vehicle, before/after SA0.00.00.10.10.10.1-0.3-0.2-0.2-0.4
Delta time to tail flick, test, before/after SA0.60.72.1-0.3-0.60.8-0.8-0.5-0.9-1.4
Tibia length0.41.02.30.70.9-1.51.01.0-0.60.9
Ambulatory time before self-admin0.92.63.8-1.3-1.51.7-1.4-1.8-1.6-1.9
Ambulatory time after self-admin0.10.10.40.30.3-0.60.2-0.10.10.4
Bone: tissue strength0.60.72.9-1.0-0.50.1-0.6-0.3-1.7-0.5
Total heroin consumption5.66.68.02.22.5-2.82.62.62.62.6
Bone: trabecular number2.75.06.92.62.3-2.22.32.22.11.9
Bone: trabecular spacing0.40.61.7-1.3-0.90.6-0.8-0.4-0.7-0.6
Bone: trabecular thickness0.00.00.1-0.1-0.00.1-0.3-0.3-0.3-0.1
Bone: trabecular tissue density1.01.82.1-1.0-1.31.4-1.4-1.4-1.5-1.3
Water consumed over 24 hours0.10.20.50.30.4-0.70.50.3-0.40.2
Number of responses in last shaping day1.41.83.0-1.7-1.31.2-1.3-1.1-0.9-1.7