Hub : Genes

Coq10a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	intron excision ratio	chr7_792811_793041	0.17	0.12	5.0e-03	0.1	0.05	0.06	0.07	2.0e-03	2.1e-02	1.6e-02	8.0e-03
2	OFC	intron excision ratio	chr7_793142_793569	0.19	0.14	3.2e-03	0.1	0.07	0.07	0.09	2.1e-03	9.6e-03	1.1e-02	4.2e-03
3	Adipose	gene expression	Coq10a	0.03	0.03	1.9e-03	0.02	0.01	0.01	0.01	4.6e-03	1.5e-02	1.0e-02	1.4e-02
4	Liver	mRNA stability	Coq10a	0.07	0.05	7.7e-08	0.04	0.06	0.06	0.05	8.8e-06	7.6e-07	5.9e-07	1.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	0.8	1.0	1.0	-1.0	-1.0	0.4
Area under the delay curve	0.0	0.0	0.0	0.2	-0.2	-0.1	0.1
BMI with tail	7.7	25.1	26.9	-5.0	5.0	4.9	-5.2
BMI without tail	1.7	3.6	3.6	-1.9	1.9	1.9	-1.9
Body weight	1.2	5.1	5.2	-2.2	2.2	2.3	-2.2
Weight adjusted by age	0.1	0.1	0.1	-0.4	0.4	0.3	-0.2
Bone surface	1.5	2.7	3.3	1.8	-1.8	-1.8	0.9
Bone volume	1.2	2.0	2.6	1.6	-1.6	-1.6	0.7
Breakpoint value in progressive ratio session	1.6	1.8	1.9	1.3	-1.3	-1.3	1.4
Number of licking bursts	4.3	5.1	5.3	-2.2	2.2	2.3	-2.3
Context. condit. distance diff. score	0.2	0.3	0.3	-0.5	0.5	0.6	-0.6
Locomotion velocity, session 1	0.1	0.1	0.2	0.4	-0.4	-0.4	0.1
Locomotion distance, session 1	0.7	0.9	1.2	1.1	-1.1	-1.0	0.6
Locomotion velocity, session 2	2.4	2.8	3.2	1.8	-1.8	-1.7	1.4
Locomotion distance, session 2	4.4	6.1	6.8	2.6	-2.6	-2.5	2.2
Locomotion velocity, session 3	5.0	5.8	6.2	2.4	-2.4	-2.3	2.5
Locomotion distance, session 3	0.1	0.1	0.1	0.3	-0.3	-0.2	0.2
Stereotopy head waving bouts, day 3	6.2	7.3	7.4	2.7	-2.7	-2.7	2.6
Stereotopy head waving duration, day 3	3.7	4.5	4.5	2.1	-2.1	-2.1	2.1
Locomotion velocity, session 7	0.2	0.2	0.2	0.4	-0.4	-0.4	0.4
Locomotion distance, session 7	0.2	0.3	0.4	-0.6	0.6	0.6	-0.4
Stereotopy head waving bouts, day 7	1.7	1.9	2.1	1.4	-1.4	-1.4	1.2
Stereotopy head waving duration, day 7	1.6	1.9	2.1	1.5	-1.5	-1.4	1.2
Locomotion velocity, session 8	2.9	3.4	3.9	2.0	-2.0	-1.8	1.6
Locomotion distance, session 8	0.6	0.8	1.0	1.0	-1.0	-0.9	0.7
Degree of sensitization distance	0.6	0.6	0.6	-0.8	0.8	0.7	-0.8
Degree of sensitization stereotypy	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.0
Conditioned locomotion	1.8	2.1	2.5	-1.6	1.6	1.4	-1.2
Cocaine response after cond. corrected	3.8	4.2	4.7	-2.2	2.2	2.1	-1.8
Cocaine response after cond. not corrected	3.9	4.3	4.8	-2.2	2.2	2.1	-1.8
Cocaine response before conditioning	0.8	1.0	1.1	1.0	-1.0	-0.9	0.9
Saline control response	0.5	0.6	0.7	-0.8	0.8	0.8	-0.7
Bone: connectivity density	0.3	0.5	0.6	0.8	-0.8	-0.8	0.3
Bone: cortical apparent density	1.7	2.2	2.3	-1.5	1.5	1.5	-1.5
Bone: cortical area	0.3	0.4	0.9	-0.5	0.5	0.5	-0.9
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.4	-0.3	0.1
Bone: cortical porosity	0.0	0.0	0.1	0.2	-0.2	-0.1	-0.3
Bone: cortical thickness	1.0	1.7	2.5	-1.2	1.2	1.2	-1.6
Bone: cortical thickness	1.0	1.1	1.3	-1.0	1.0	1.2	-1.1
Bone: cortical tissue density	1.3	1.7	1.7	-1.3	1.3	1.3	-1.3
Condit. Reinf. active minus inactive responses	2.2	2.4	2.6	1.6	-1.6	-1.4	1.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.4	-0.4	-0.2	0.5
Condit. Reinf. active responses	3.6	4.4	4.9	2.2	-2.2	-2.1	1.9
Condit. Reinf. inactive responses	2.3	2.7	3.0	1.7	-1.7	-1.7	1.3
Incentive salience index mean	2.0	2.4	2.7	1.6	-1.6	-1.5	1.4
Condit. Reinf. lever presses	1.1	1.5	1.9	1.4	-1.4	-1.2	0.9
Condit. Reinf. active minus inactive responses	1.1	1.3	1.8	1.1	-1.1	-1.1	1.3
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.2	-0.1	0.1	-0.1	0.4
Condit. Reinf. active responses	1.1	1.5	1.6	1.2	-1.2	-1.2	1.3
Condit. Reinf. inactive responses	0.6	0.7	0.8	0.9	-0.9	-0.8	0.7
Condit. Reinf. lever presses	1.9	2.5	3.2	1.5	-1.5	-1.5	1.8
Condit. Reinf. lever reinforcers received	0.7	1.0	1.1	1.0	-1.0	-1.0	1.0
Conditioned reinforcement - actives	0.0	0.0	0.1	0.2	-0.2	-0.3	0.1
Conditioned reinforcement - inactives	2.2	2.5	2.7	-1.6	1.6	1.7	-1.4
Conditioned locomotion	2.2	2.7	2.7	1.7	-1.7	-1.6	1.6
Patch foraging indifference point 0 sec	3.2	5.1	6.3	-2.1	2.1	2.3	-2.5
Patch foraging indifference point AUC	0.6	0.6	0.7	0.8	-0.8	-0.8	0.8
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	-0.3	0.3	0.4	-0.8
Delay disc. indifference point, 16s delay	0.3	0.3	0.3	0.5	-0.5	-0.6	0.6
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.0	0.0	0.1	-0.2
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.3	0.3	0.3	-0.4
Delay disc. indifference point, 4s delay	0.8	0.9	1.0	1.0	-1.0	-1.0	0.8
Delay disc. indifference point, 8s delay	0.2	0.2	0.2	-0.4	0.4	0.5	-0.3
Indifference point function ln k	0.2	0.3	0.3	-0.6	0.6	0.6	-0.5
Indifference point function log k	0.2	0.3	0.3	-0.6	0.6	0.6	-0.5
Patch foraging total patch changes 0 sec	3.1	5.0	6.2	-2.1	2.1	2.3	-2.5
Patch foraging total patch changes 12 sec	2.3	3.0	3.2	-1.7	1.7	1.7	-1.8
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.2	0.2	0.1	-0.2
Patch foraging total patch changes 24 sec	0.3	0.3	0.6	-0.5	0.5	0.6	-0.8
Patch foraging total patch changes 6 sec	1.9	2.8	3.4	-1.6	1.6	1.6	-1.8
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.3	0.3	0.2	-0.3
Patch foraging water rate 0 sec	0.9	1.4	1.6	-1.1	1.1	1.3	-1.2
Patch foraging water rate 12 sec	1.3	2.0	2.2	-1.5	1.5	1.5	-1.3
Patch foraging water rate 18 sec	0.4	0.5	0.7	-0.7	0.7	0.9	-0.3
Patch foraging water rate 24 sec	3.0	4.2	4.6	-2.2	2.2	2.1	-1.7
Patch foraging water rate 6 sec	0.0	0.0	0.2	0.0	-0.0	0.0	0.4
Seeking ratio, delayed vs. immediate footshock	1.6	1.8	1.9	1.4	-1.4	-1.4	1.3
Distance traveled before self-admin	1.2	1.3	1.4	1.2	-1.2	-1.2	1.0
Distance traveled after self-admin	0.3	0.3	0.4	0.6	-0.6	-0.6	0.3
Extensor digitorum longus weight	6.6	25.9	26.7	-5.2	5.2	5.1	-4.9
Bone: elastic displacement	0.0	0.0	0.0	0.0	-0.0	-0.1	0.0
Bone: elastic work	0.3	0.4	0.5	-0.6	0.6	0.5	-0.7
Bone: endosteal estimation	0.4	0.8	1.0	-0.9	0.9	0.8	-1.0
Bone: endosteal perimeter	0.4	0.8	1.1	0.9	-0.9	-1.0	0.6
Epididymis fat weight	0.0	0.1	0.1	0.3	-0.3	-0.3	0.4
Delta time in closed arm before/after self-admin	2.6	2.5	2.8	-1.7	1.7	1.7	-1.3
Delta time in open arm before/after self-admin	0.6	0.6	0.7	-0.7	0.7	0.8	-0.8
Diff in mean of infusions in LGA sessions	1.8	2.0	2.0	1.4	-1.4	-1.4	1.4
Delay discount exponential model param	0.0	0.0	0.0	-0.2	0.2	0.2	-0.1
Extinction: sum of active levers before priming	1.8	1.8	2.7	1.3	-1.3	-1.2	1.6
Active lever presses in extinction session 6	1.6	1.6	1.7	1.3	-1.3	-1.3	1.1
Bone: final force	1.4	2.3	3.5	-1.4	1.4	1.4	-1.9
Bone: final moment	1.3	2.2	3.3	-1.3	1.3	1.4	-1.8
Food consumed during 24 hour testing period	0.4	0.5	0.6	-0.7	0.7	0.7	-0.8
Glucose	1.7	2.6	3.0	-1.5	1.5	1.6	-1.7
Heart weight	0.2	0.2	0.3	-0.5	0.5	0.5	-0.3
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.1	0.1	0.0	0.1
Intermittent access intake day 1-15 change	0.1	0.1	0.1	0.2	-0.2	-0.2	0.3
Intermittent access intake escalation	0.1	0.1	0.2	-0.3	0.3	0.4	-0.0
Intermittent access intake escalation 2	0.1	0.1	0.2	0.1	-0.1	-0.1	0.4
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.3	-0.5	0.5	0.5	-0.2
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.5	0.5	-0.5	-0.4	0.7
Intermitt. access escalation Index	0.4	0.4	0.5	0.7	-0.7	-0.6	0.3
Intermittent access day 1 total infusions	0.2	0.3	0.4	-0.5	0.5	0.5	-0.6
Intermittent access day 15 total infusions	0.3	0.3	0.4	-0.5	0.5	0.6	-0.5
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	-0.3	0.3	0.3	-0.4
Intermittent access total infusions	0.5	0.5	0.5	-0.7	0.7	0.7	-0.7
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.3	-0.3	-0.3	0.4
Intermittent access total locomotion	0.2	0.2	0.3	0.5	-0.5	-0.5	0.5
Intermittent access standard deviation	0.0	0.0	0.0	0.0	-0.0	0.0	0.2
Left kidney weight	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1
Right kidney weight	0.3	0.8	0.9	0.8	-0.8	-0.9	1.0
Cocaine induced anxiety	2.5	2.9	3.1	1.8	-1.8	-1.8	1.6
Post-drug Anxiety	1.2	1.4	1.5	1.2	-1.2	-1.2	0.9
Baseline Anxiety	0.1	0.1	0.1	-0.2	0.2	0.2	-0.2
Tail length	4.2	12.6	15.0	3.4	-3.4	-3.4	3.9
Length with tail	1.9	6.8	7.6	2.6	-2.6	-2.5	2.7
Length without tail	0.0	0.0	0.0	-0.0	0.0	0.0	-0.2
Times rat made contact with spout	1.4	1.6	1.7	-1.3	1.3	1.3	-1.2
Lifetime Intake	0.8	0.9	1.2	-0.9	0.9	0.9	-1.1
Liver weight, left	2.1	3.3	3.6	-1.8	1.8	1.9	-1.8
Liver weight, right	0.9	1.5	1.7	-1.2	1.2	1.2	-1.3
Locomotor activity	4.9	7.8	8.4	2.9	-2.9	-2.6	2.7
Locomotor testing distance	1.8	3.0	3.2	1.8	-1.8	-1.6	1.7
Locomotor testing rearing	0.0	0.0	0.0	0.0	-0.0	0.1	0.1
Locomotion in novel chamber	0.4	0.4	0.5	-0.7	0.7	0.5	-0.7
Locomotion in novel chamber post-restriction	3.5	4.2	4.3	2.1	-2.1	-2.0	2.0
Fecal boli incidents, locomotor time 1	1.2	1.4	1.5	-1.2	1.2	1.1	-1.1
Change in fecal boli incidents, locomotor task	1.4	1.3	1.5	1.2	-1.2	-1.1	1.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.4	-0.4	0.4	0.3	-0.6
Bouts of movement, locomotor time 1	0.3	0.3	0.4	0.5	-0.5	-0.6	0.7
Total resting periods, locomotor time 1	1.0	1.1	1.2	1.0	-1.0	-1.1	1.1
Rest time, locomotor task time 1	0.6	0.7	0.8	0.8	-0.8	-0.9	0.9
Distance moved, locomotor task time 1	0.2	0.2	0.6	-0.3	0.3	0.4	-0.7
Vertical activity count, locomotor time 1	1.4	1.5	1.7	-1.2	1.2	1.3	-1.2
Time >=10cm from walls, locomotor time 2	1.8	1.9	1.9	-1.4	1.4	1.3	-1.4
Bouts of movement, locomotor time 2	0.7	0.7	0.9	0.9	-0.9	-0.9	0.6
Total resting periods, locomotor time 2	0.7	0.7	0.9	0.9	-0.9	-0.9	0.6
Rest time, locomotor task time 2	0.3	0.3	0.3	0.5	-0.5	-0.5	0.5
Distance moved, locomotor task time 2	0.2	0.3	0.3	-0.5	0.5	0.5	-0.5
Vertical activity count, locomotor time 2	2.3	2.5	2.8	-1.5	1.5	1.7	-1.5
Light reinforcement 1	3.8	7.0	7.4	2.6	-2.6	-2.6	2.7
Light reinforcement 2	1.0	1.4	1.5	1.2	-1.2	-1.2	1.1
Bone: marrow area	0.3	0.7	0.8	-0.8	0.8	0.8	-0.9
Bone: maximum diameter	0.6	1.2	1.3	1.1	-1.1	-1.1	0.9
Bone: maximum force	1.8	3.1	4.0	-1.7	1.7	1.6	-2.0
Bone: maximum moment	1.7	2.9	3.9	-1.6	1.6	1.6	-2.0
Mean time between licks in bursts	0.4	0.6	0.7	0.7	-0.7	-0.7	0.8
Mean num. licks in bursts	1.0	1.2	1.5	1.1	-1.1	-1.1	1.2
Cd content in liver	0.4	0.4	0.5	-0.6	0.6	0.7	-0.7
Co content in liver	0.7	0.8	1.0	0.8	-0.8	-0.8	1.0
Cu content in liver	0.5	0.6	1.1	-0.6	0.6	0.7	-1.1
Fe content in liver	0.8	1.0	1.1	-1.0	1.0	1.0	-0.9
K content in liver	0.9	0.9	1.0	0.9	-0.9	-1.0	0.9
Mg content in liver	0.8	0.8	1.1	0.9	-0.9	-1.0	0.7
Mn content in liver	1.6	1.8	2.3	1.4	-1.4	-1.5	0.9
Na content in liver	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.1
Rb content in liver	0.2	0.2	0.5	-0.4	0.4	0.3	-0.7
Se content in liver	0.1	0.1	0.1	0.2	-0.2	-0.4	0.2
Sr content in liver	0.0	0.0	0.0	-0.1	0.1	0.2	0.0
Zn content in liver	0.6	0.7	1.2	0.7	-0.7	-0.7	1.1
Bone: minimum diameter	0.0	0.1	0.2	-0.2	0.2	0.2	-0.4
Time in familiar zone, hab. session 1	4.5	4.2	4.9	2.0	-2.0	-2.0	2.2
Time in novel zone, hab. session 1	2.2	2.1	2.9	-1.4	1.4	1.4	-1.7
Total zone transitions, hab. session 1	1.1	1.5	1.7	1.3	-1.3	-1.3	0.9
Total locomotion distance, hab. session 1	3.3	4.7	5.4	2.3	-2.3	-2.2	1.8
Locomotion velocity, hab. session 1	3.2	4.5	5.1	2.3	-2.3	-2.1	1.8
Time in familiar zone, hab. session 2	3.4	3.5	4.7	1.7	-1.7	-1.8	2.2
Time in novel zone, hab. session 2	3.6	3.6	5.0	-1.8	1.8	1.8	-2.2
Total zone transitions, hab. session 2	0.0	0.1	0.2	0.1	-0.1	-0.0	-0.4
Total locomotion distance, hab. session 2	0.8	1.1	1.3	1.1	-1.1	-1.1	0.8
Locomotion velocity, hab. session 2	1.1	1.5	1.7	1.3	-1.3	-1.2	0.9
Novel to familiar place preference ratio	1.2	1.3	2.4	-0.9	0.9	1.1	-1.5
Novelty place preference	0.7	0.7	1.5	-0.6	0.6	0.8	-1.2
Time in novel zone, NPP test	1.2	1.2	2.2	-0.9	0.9	1.1	-1.5
Total zone transitions, NPP test	0.0	0.1	0.2	-0.1	0.1	0.1	-0.4
Total locomotion distance, NPP test	0.1	0.1	0.2	0.4	-0.4	-0.4	0.1
Locomotion velocity, NPP test	0.3	0.4	0.5	0.7	-0.7	-0.7	0.4
Intraocular pressure	0.1	0.1	0.3	0.2	-0.2	-0.1	0.6
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	0.1	0.1	-0.3
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.2
Parametrial fat weight	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1
Pavlov. Cond. lever latency	0.4	0.4	0.6	-0.8	0.8	0.7	-0.4
Pavlov. Cond. magazine entry latency	1.3	1.7	2.0	1.3	-1.3	-1.3	1.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	0.2	0.4	-0.5
Pavlov. Cond. index score	0.8	1.0	1.2	1.1	-1.1	-1.0	0.9
Pavlov. Cond. latency score	1.1	1.3	1.6	1.2	-1.2	-1.1	1.0
Pavlov. Cond. lever contacts	0.4	0.5	0.6	0.8	-0.8	-0.7	0.4
Pavlov. Cond. magazine entry number	0.5	0.7	0.7	-0.8	0.8	0.8	-0.9
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.0	0.0	0.2	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.4	1.2	-1.2	-1.1	1.0
Pavlov. Cond. response bias	0.9	1.1	1.1	1.1	-1.1	-1.0	1.0
Pavlov. Cond. lever latency	1.6	2.2	2.5	-1.5	1.5	1.5	-1.6
Pavlov. Cond. magazine entry latency	2.6	3.0	3.1	1.7	-1.7	-1.7	1.7
Pavlov. Cond. change in total contacts	0.6	0.8	0.9	0.9	-0.9	-0.9	1.0
Pavlov. Cond. index score	1.9	2.5	2.6	1.6	-1.6	-1.6	1.6
Pavlov. Cond. latency score	2.4	3.0	3.0	1.7	-1.7	-1.7	1.7
Pavlov. Cond. lever contacts	1.1	1.5	1.7	1.2	-1.2	-1.2	1.3
Pavlov. Cond. magazine entry number	2.3	2.8	2.9	-1.7	1.7	1.7	-1.6
Pavlov. Cond. intertrial magazine entries	1.2	1.6	1.8	-1.3	1.3	1.3	-1.0
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.7	2.7	1.6	-1.6	-1.6	1.6
Pavlov. Cond. response bias	1.7	2.4	2.7	1.5	-1.5	-1.5	1.6
Time in closed arm before self-admin	0.0	0.0	0.1	0.2	-0.2	-0.2	-0.2
Time in closed arm after self-admin	0.4	0.4	0.4	-0.6	0.6	0.6	-0.6
Time in open arm before self-admin	0.0	0.0	0.0	0.2	-0.2	-0.1	0.2
Time in open arm after self-admin	1.2	1.3	1.4	-1.1	1.1	1.2	-1.1
Bone: periosteal estimation	0.4	0.8	1.3	-0.8	0.8	0.7	-1.1
Bone: periosteal perimeter	0.1	0.2	0.3	0.4	-0.4	-0.5	0.0
Bone: post-yield work	0.3	0.4	0.5	-0.7	0.7	0.7	-0.6
Progressive ratio test 1 active lever presses	1.5	1.6	1.7	-1.2	1.2	1.3	-1.3
Progressive ratio test 1 breakpoint	1.5	1.6	1.6	-1.2	1.2	1.3	-1.3
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1
Progressive ratio test 2 active lever presses	0.5	0.6	0.6	-0.7	0.7	0.7	-0.8
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.1	0.1	0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.3	0.3	0.4	-0.5
Incentive Sensitization - Responses	0.1	0.1	0.1	0.2	-0.2	-0.3	0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.2	0.4	-0.4	-0.4	0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	0.6	-0.6	-0.5	0.4
Progressive ratio	1.5	1.7	1.9	-1.3	1.3	1.4	-1.3
Food seeking constrained by brief footshock	1.8	2.2	2.4	1.6	-1.6	-1.4	1.5
Seeking ratio, punishment vs. effort	2.6	3.1	3.2	1.8	-1.8	-1.7	1.8
Retroperitoneal fat weight	2.6	8.7	9.3	-3.0	3.0	3.1	-2.8
Reaction time number correct	1.5	2.1	2.3	-1.5	1.5	1.5	-1.3
Reaction time mean minus median	1.9	2.5	3.3	1.5	-1.5	-1.5	1.8
Reaction time mean minus median AUC	2.9	3.8	3.9	2.0	-2.0	-2.0	1.9
Reaction time num false alarms	0.6	0.9	1.1	-0.8	0.8	1.0	-1.1
Reaction time num false alarms AUC	0.9	1.2	1.5	-1.0	1.0	1.2	-1.1
Reaction time trials correct on left	1.5	2.1	2.3	-1.5	1.5	1.5	-1.3
Reaction time trials on left	1.4	2.0	2.1	-1.5	1.5	1.4	-1.3
Reaction time mean	1.6	2.2	2.4	1.4	-1.4	-1.6	1.5
Reaction time mean AUC	0.8	1.0	1.2	1.0	-1.0	-1.1	1.0
Median of all reaction times	0.8	1.1	1.3	1.0	-1.0	-1.1	1.0
Reaction time omissions	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.1
Reaction time false alarm rate	0.0	0.1	0.1	-0.1	0.1	0.3	-0.4
Reaction time premature initiation rate	0.8	1.1	1.7	1.0	-1.0	-0.9	1.3
Reaction time premature initiations	0.1	0.1	0.4	0.1	-0.1	-0.0	0.6
Std. dev. reaction times	1.2	1.6	1.9	1.2	-1.2	-1.3	1.4
Reaction time trials completed	1.4	2.0	2.1	-1.5	1.5	1.4	-1.3
Reaction time trials AUC	1.7	2.4	2.6	-1.6	1.6	1.6	-1.4
Run reversals in cocaine runway, females	2.4	2.3	2.4	1.6	-1.6	-1.6	1.4
Run reversals in cocaine runway, males	3.0	2.9	3.1	1.8	-1.8	-1.7	1.6
Latency to leave start box in cocaine runway	0.1	0.2	0.2	0.4	-0.4	-0.5	0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	0.6	-0.6	-0.6	0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.5	0.5	0.3	-0.1
Std. dev. time between licks in bursts	0.8	1.0	1.2	1.1	-1.1	-1.0	0.7
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.4
Short access day 1 total inactive lever presses	0.0	0.0	0.0	-0.1	0.1	0.1	-0.2
Short access day 10 total inactive lever presses	0.3	0.3	0.3	-0.6	0.6	0.5	-0.4
Short access day 1 total infusions	0.2	0.2	0.6	-0.3	0.3	0.4	-0.8
Short access day 10 total infusions	0.7	0.8	1.0	-0.9	0.9	0.9	-1.0
Short access total infusions	0.8	0.9	1.6	-0.8	0.8	0.9	-1.3
Short access day 1 locomotion	0.1	0.1	0.2	0.4	-0.4	-0.4	0.3
Short access day 10 total locomotion	0.5	0.6	1.0	0.6	-0.6	-0.8	1.0
Short access total locomotion	0.2	0.2	0.2	0.4	-0.4	-0.4	0.4
One hour access (0.3 mA shock)	0.5	0.6	0.7	-0.8	0.8	0.6	-0.7
Compulsive drug intake	0.2	0.2	0.2	-0.4	0.4	0.3	-0.5
One hour access (shock baseline)	0.3	0.4	0.4	-0.7	0.7	0.6	-0.5
Social response proportion	1.4	1.5	1.6	1.2	-1.2	-1.3	1.1
Social responses	11.1	14.3	14.6	3.7	-3.7	-3.8	3.8
Social time	1.3	1.7	1.9	-1.4	1.4	1.2	-1.1
Soleus weight	6.4	18.7	18.8	-4.3	4.3	4.3	-4.3
Bone: stiffness	3.5	5.5	6.7	-2.2	2.2	2.3	-2.6
Tibialis anterior weight	1.2	4.1	4.4	-2.1	2.1	2.1	-1.8
Time to tail flick, vehicle, before self-admin	2.6	2.6	3.0	1.7	-1.7	-1.7	1.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.2	0.1	-0.1	-0.1	0.4
Time to tail flick, test, before self-admin	1.9	1.9	2.0	1.4	-1.4	-1.3	1.3
Time to tail flick, test, after self-admin	0.4	0.4	0.5	0.7	-0.7	-0.7	0.6
Delta time to tail flick, vehicle, before/after SA	1.7	1.7	2.0	-1.4	1.4	1.4	-1.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.1	0.1	-0.0	0.1
Tibia length	0.9	2.6	3.4	1.6	-1.6	-1.5	1.8
Ambulatory time before self-admin	0.3	0.3	0.4	0.6	-0.6	-0.6	0.5
Ambulatory time after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.3	0.0
Bone: tissue strength	3.8	3.7	4.0	-1.9	1.9	1.8	-2.0
Total heroin consumption	3.0	3.5	3.6	1.9	-1.9	-1.9	1.8
Bone: trabecular number	1.6	2.5	2.7	1.6	-1.6	-1.7	1.3
Bone: trabecular spacing	1.4	1.8	2.1	-1.4	1.4	1.5	-1.0
Bone: trabecular thickness	0.8	0.9	1.2	1.1	-1.1	-1.1	0.4
Bone: trabecular tissue density	7.3	10.3	10.6	-3.2	3.2	3.3	-3.2
Water consumed over 24 hours	0.3	0.4	0.9	-0.5	0.5	0.5	-1.0
Number of responses in last shaping day	0.7	0.7	0.8	0.9	-0.9	-0.8	0.9