Hub : Genes

Coq10a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC intron excision ratio chr7_1377313_1377543 0.16 0.11 3.8e-03 0.06 0.05 0.05 0.04 1.8e-02 2.4e-02 2.6e-02 4.0e-02
2 Liver mRNA stability Coq10a 0.07 0.05 6.7e-08 0.05 0.06 0.06 0.05 6.9e-06 5.8e-07 4.3e-07 1.2e-06
3 Adipose gene expression Coq10a 0.03 0.03 1.6e-03 0.02 0.01 0.02 0.01 2.8e-03 1.2e-02 3.0e-03 9.1e-03
4 OFC intron excision ratio chr7_1377644_1378071 0.17 0.12 2.7e-03 0.06 0.07 0.06 0.06 1.8e-02 1.1e-02 2.0e-02 1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.40.71.7-0.8-0.00.61.3
Area under the delay curve0.00.00.0-0.10.00.10.1
BMI with tail7.726.530.15.25.5-5.2-4.6
BMI without tail1.85.66.62.32.6-2.2-2.3
Body weight1.14.85.42.12.2-2.1-2.3
Weight adjusted by age0.00.00.0-0.1-0.10.1-0.1
Bone surface1.52.85.9-1.6-0.71.42.4
Bone volume1.22.15.0-1.4-0.41.22.2
Breakpoint value in progressive ratio session0.70.81.1-0.9-1.00.90.8
Number of licking bursts2.84.65.02.22.0-2.2-2.2
Context. condit. distance diff. score0.40.50.70.80.7-0.8-0.5
Locomotion velocity, session 10.10.20.5-0.30.00.30.7
Locomotion distance, session 10.81.01.9-1.0-0.60.91.4
Locomotion velocity, session 22.63.04.4-1.7-1.31.72.1
Locomotion distance, session 24.96.87.5-2.7-2.32.72.7
Locomotion velocity, session 33.84.35.8-1.9-2.42.01.9
Locomotion distance, session 30.10.10.1-0.2-0.40.30.1
Stereotopy head waving bouts, day 35.86.87.1-2.6-2.72.62.5
Stereotopy head waving duration, day 33.23.94.1-1.9-2.01.92.0
Locomotion velocity, session 70.10.10.2-0.3-0.20.10.5
Locomotion distance, session 70.40.50.70.80.4-0.8-0.8
Stereotopy head waving bouts, day 71.41.52.4-1.1-1.11.11.6
Stereotopy head waving duration, day 71.61.92.8-1.3-1.11.41.7
Locomotion velocity, session 82.42.84.3-1.6-1.41.62.1
Locomotion distance, session 80.50.81.0-0.8-0.80.91.0
Degree of sensitization distance0.90.91.21.10.9-1.1-0.7
Degree of sensitization stereotypy0.00.00.20.10.1-0.10.4
Conditioned locomotion1.61.82.71.41.1-1.2-1.6
Cocaine response after cond. corrected4.14.96.02.41.9-2.3-2.1
Cocaine response after cond. not corrected4.35.06.02.51.9-2.3-2.3
Cocaine response before conditioning0.80.91.0-1.0-0.91.00.8
Saline control response0.40.51.10.50.7-0.6-1.1
Bone: connectivity density0.20.30.9-0.5-0.00.41.0
Bone: cortical apparent density1.11.52.11.31.4-1.1-1.0
Bone: cortical area0.20.40.90.40.9-0.60.2
Bone: cortical porosity0.00.10.1-0.20.00.20.4
Bone: cortical porosity0.10.10.2-0.10.30.00.4
Bone: cortical thickness0.71.22.41.01.6-1.0-0.7
Bone: cortical thickness0.81.01.31.01.0-0.8-1.1
Bone: cortical tissue density0.81.01.51.11.2-0.9-0.8
Condit. Reinf. active minus inactive responses1.31.51.9-1.0-1.41.01.4
Condit. Reinf. active-inactive response ratio0.10.10.10.3-0.3-0.30.0
Condit. Reinf. active responses3.03.84.5-1.9-1.91.92.1
Condit. Reinf. inactive responses3.03.64.2-2.0-1.62.01.9
Incentive salience index mean1.41.72.5-1.2-1.31.21.6
Condit. Reinf. lever presses1.11.52.6-1.2-0.81.21.6
Condit. Reinf. active minus inactive responses1.31.72.8-1.4-1.71.20.8
Condit. Reinf. active-inactive response ratio0.20.20.5-0.3-0.70.1-0.4
Condit. Reinf. active responses1.31.82.4-1.4-1.61.31.1
Condit. Reinf. inactive responses0.50.60.9-0.8-0.70.80.9
Condit. Reinf. lever presses1.92.73.6-1.8-1.91.71.1
Condit. Reinf. lever reinforcers received0.81.11.7-1.1-1.31.00.8
Conditioned reinforcement - actives0.10.10.10.30.3-0.4-0.2
Conditioned reinforcement - inactives0.71.01.11.00.9-1.0-1.1
Conditioned locomotion1.72.32.4-1.5-1.41.51.6
Patch foraging indifference point 0 sec2.64.86.72.12.6-2.2-1.7
Patch foraging indifference point AUC0.30.40.8-0.5-0.90.40.6
Delay disc. indifference point, 0s delay0.30.41.00.51.0-0.50.1
Delay disc. indifference point, 16s delay0.30.40.5-0.7-0.60.70.5
Delay disc. indifference point, 2s delay0.00.00.10.10.4-0.10.2
Delay disc. indifference point, 24s delay0.10.10.10.20.3-0.2-0.3
Delay disc. indifference point, 4s delay0.80.81.1-0.9-0.70.91.1
Delay disc. indifference point, 8s delay0.20.20.40.40.3-0.4-0.6
Indifference point function ln k0.10.10.20.40.4-0.3-0.4
Indifference point function log k0.10.10.20.40.4-0.3-0.4
Patch foraging total patch changes 0 sec2.44.46.12.02.5-2.2-1.6
Patch foraging total patch changes 12 sec2.32.93.11.71.7-1.8-1.6
Patch foraging total patch changes 18 sec0.00.00.0-0.00.1-0.10.0
Patch foraging total patch changes 24 sec0.10.30.40.40.6-0.6-0.3
Patch foraging total patch changes 6 sec1.72.63.31.61.8-1.7-1.2
Patch foraging time to switch 0 sec0.00.10.20.20.40.10.1
Patch foraging water rate 0 sec0.71.51.81.21.0-1.4-1.3
Patch foraging water rate 12 sec1.02.22.61.51.2-1.6-1.5
Patch foraging water rate 18 sec0.71.02.11.00.3-1.0-1.5
Patch foraging water rate 24 sec3.44.87.22.21.6-2.2-2.7
Patch foraging water rate 6 sec0.10.10.20.1-0.4-0.3-0.5
Seeking ratio, delayed vs. immediate footshock1.61.92.1-1.4-1.31.41.5
Distance traveled before self-admin1.41.82.0-1.4-1.41.41.2
Distance traveled after self-admin0.00.00.0-0.1-0.20.10.1
Extensor digitorum longus weight5.722.323.34.84.8-4.7-4.7
Bone: elastic displacement0.00.00.1-0.2-0.00.20.0
Bone: elastic work0.30.40.80.40.9-0.6-0.4
Bone: endosteal estimation0.30.71.10.81.0-1.0-0.3
Bone: endosteal perimeter0.61.21.9-1.1-0.81.01.4
Epididymis fat weight0.00.10.20.1-0.3-0.1-0.5
Delta time in closed arm before/after self-admin3.73.44.71.91.4-1.9-2.2
Delta time in open arm before/after self-admin0.50.50.60.70.8-0.7-0.7
Diff in mean of infusions in LGA sessions1.51.82.3-1.4-1.51.41.1
Delay discount exponential model param0.00.00.10.30.1-0.3-0.1
Extinction: sum of active levers before priming0.70.71.5-0.8-1.20.80.5
Active lever presses in extinction session 60.20.20.3-0.5-0.40.50.6
Bone: final force1.42.33.91.42.0-1.6-0.7
Bone: final moment1.42.23.81.42.0-1.6-0.7
Food consumed during 24 hour testing period0.10.20.30.10.6-0.1-0.5
Glucose1.21.92.01.41.4-1.4-1.2
Heart weight0.00.10.2-0.2-0.40.3-0.0
Delay discount hyperbolic model param0.00.00.00.1-0.2-0.1-0.1
Intermittent access intake day 1-15 change0.10.10.3-0.4-0.50.30.0
Intermittent access intake escalation0.10.10.2-0.3-0.50.3-0.0
Intermittent access intake escalation 20.30.30.6-0.6-0.80.50.4
Intermitt. access day 1 inactive lever presses0.00.10.20.0-0.4-0.0-0.5
Intermitt. access day 15 inactive lever presses0.40.91.1-1.0-1.11.00.6
Intermitt. access escalation Index0.10.10.2-0.30.10.30.4
Intermittent access day 1 total infusions0.30.40.50.70.6-0.7-0.6
Intermittent access day 15 total infusions0.00.00.00.10.2-0.2-0.1
Intermittent access terminal intake (last 3 days)0.10.10.2-0.3-0.10.20.4
Intermittent access total infusions0.10.10.20.40.5-0.4-0.2
Intermittent access day 1 locomotion0.30.40.60.60.4-0.6-0.8
Intermittent access day 15 total locomotion0.00.00.0-0.0-0.2-0.0-0.1
Intermittent access total locomotion0.00.00.0-0.0-0.2-0.0-0.0
Intermittent access standard deviation0.40.80.9-1.0-0.80.91.0
Left kidney weight0.00.00.1-0.1-0.00.2-0.2
Right kidney weight0.10.40.5-0.6-0.70.70.2
Cocaine induced anxiety2.23.13.8-1.8-1.51.81.9
Post-drug Anxiety2.12.23.5-1.5-1.01.51.9
Baseline Anxiety0.00.00.00.10.1-0.1-0.1
Tail length3.312.815.5-3.7-3.93.82.8
Length with tail1.25.37.0-2.4-2.62.41.5
Length without tail0.31.11.31.00.9-1.1-1.1
Times rat made contact with spout1.51.72.01.21.2-1.3-1.4
Lifetime Intake0.60.71.10.81.0-0.9-0.6
Liver weight, left0.20.40.60.50.7-0.4-0.8
Liver weight, right0.10.10.3-0.2-0.50.2-0.0
Locomotor activity4.97.69.0-3.0-2.62.92.5
Locomotor testing distance2.03.64.1-2.0-1.82.01.8
Locomotor testing rearing0.00.00.0-0.2-0.20.2-0.2
Locomotion in novel chamber0.10.10.10.20.4-0.2-0.3
Locomotion in novel chamber post-restriction3.55.76.9-2.4-2.62.42.1
Fecal boli incidents, locomotor time 10.81.21.61.10.9-1.1-1.3
Change in fecal boli incidents, locomotor task1.21.21.9-1.0-0.81.11.4
Time >=10cm from walls, locomotor time 10.10.10.30.20.5-0.20.2
Bouts of movement, locomotor time 10.60.60.8-0.9-0.90.80.5
Total resting periods, locomotor time 11.41.61.9-1.4-1.31.31.0
Rest time, locomotor task time 10.91.11.3-1.1-1.01.01.0
Distance moved, locomotor task time 10.20.30.70.50.8-0.60.0
Vertical activity count, locomotor time 10.81.82.11.41.4-1.4-1.2
Time >=10cm from walls, locomotor time 21.11.61.71.31.2-1.3-1.3
Bouts of movement, locomotor time 20.50.81.0-0.9-0.51.00.9
Total resting periods, locomotor time 20.50.81.1-1.0-0.51.01.0
Rest time, locomotor task time 20.30.40.6-0.7-0.40.60.8
Distance moved, locomotor task time 20.20.20.40.50.3-0.5-0.6
Vertical activity count, locomotor time 21.72.32.91.61.3-1.5-1.7
Light reinforcement 13.38.09.2-2.9-2.83.02.5
Light reinforcement 21.52.22.8-1.7-1.41.71.2
Bone: marrow area0.30.61.00.71.0-0.9-0.3
Bone: maximum diameter0.81.52.6-1.3-0.90.91.6
Bone: maximum force1.52.64.21.52.0-1.8-0.9
Bone: maximum moment1.52.64.21.52.1-1.7-0.9
Mean time between licks in bursts0.20.60.7-0.7-0.80.80.6
Mean num. licks in bursts0.71.11.3-1.1-1.01.10.9
Cd content in liver0.20.20.2-0.4-0.30.50.5
Co content in liver2.63.03.9-1.9-1.82.01.1
Cu content in liver0.20.20.30.40.6-0.40.3
Fe content in liver0.50.60.80.80.7-0.9-0.7
K content in liver1.41.31.5-1.2-1.01.21.2
Mg content in liver1.61.61.7-1.3-1.21.31.3
Mn content in liver3.43.75.7-1.9-1.41.92.4
Na content in liver0.00.10.10.20.2-0.20.3
Rb content in liver0.10.10.20.10.3-0.10.5
Se content in liver0.00.00.10.3-0.0-0.20.1
Sr content in liver0.10.00.1-0.3-0.10.2-0.2
Zn content in liver1.21.32.7-1.1-1.61.10.4
Bone: minimum diameter0.10.10.20.10.5-0.20.4
Time in familiar zone, hab. session 13.63.55.2-1.9-2.31.71.5
Time in novel zone, hab. session 11.71.73.41.31.8-1.1-0.7
Total zone transitions, hab. session 11.11.52.4-1.2-0.91.11.5
Total locomotion distance, hab. session 13.55.06.8-2.3-1.82.12.6
Locomotion velocity, hab. session 13.34.65.9-2.2-1.82.12.4
Time in familiar zone, hab. session 23.53.75.0-2.1-2.22.01.2
Time in novel zone, hab. session 23.83.85.42.12.3-2.1-1.2
Total zone transitions, hab. session 20.10.20.4-0.00.50.10.6
Total locomotion distance, hab. session 21.21.51.8-1.3-0.91.31.4
Locomotion velocity, hab. session 21.52.12.6-1.6-1.01.51.6
Novel to familiar place preference ratio1.51.62.61.31.6-1.4-0.5
Novelty place preference0.91.01.71.01.3-1.1-0.3
Time in novel zone, NPP test1.41.52.41.31.6-1.3-0.5
Total zone transitions, NPP test0.00.00.2-0.00.4-0.00.2
Total locomotion distance, NPP test0.20.30.6-0.6-0.10.60.8
Locomotion velocity, NPP test0.50.71.0-0.9-0.40.91.0
Intraocular pressure0.10.10.3-0.2-0.50.3-0.4
Delta distance traveled before/after self-admin0.70.70.70.90.8-0.9-0.8
Delta ambulatory time before/after self-admin0.40.40.60.70.8-0.7-0.5
Parametrial fat weight0.40.91.21.11.0-1.0-0.6
Pavlov. Cond. lever latency0.50.61.30.80.3-0.8-1.1
Pavlov. Cond. magazine entry latency1.51.92.2-1.5-1.41.51.2
Pavlov. Cond. change in total contacts0.20.20.30.50.6-0.4-0.2
Pavlov. Cond. index score0.81.11.3-1.1-0.81.11.1
Pavlov. Cond. latency score1.11.41.8-1.2-0.81.21.3
Pavlov. Cond. lever contacts0.30.30.8-0.5-0.10.60.9
Pavlov. Cond. magazine entry number0.50.70.70.90.8-0.9-0.7
Pavlov. Cond. intertrial magazine entries0.10.10.20.2-0.1-0.2-0.5
Pavlov. Cond. lever-magazine prob. diff.0.81.01.2-1.0-0.81.11.1
Pavlov. Cond. response bias0.50.60.7-0.8-0.80.90.7
Pavlov. Cond. lever latency1.82.52.81.61.7-1.7-1.3
Pavlov. Cond. magazine entry latency2.63.13.4-1.9-1.81.81.5
Pavlov. Cond. change in total contacts0.60.91.1-1.0-1.01.00.7
Pavlov. Cond. index score2.02.73.0-1.7-1.71.71.3
Pavlov. Cond. latency score2.43.23.5-1.9-1.91.91.5
Pavlov. Cond. lever contacts1.52.02.4-1.5-1.61.51.1
Pavlov. Cond. magazine entry number2.63.23.41.81.8-1.8-1.6
Pavlov. Cond. intertrial magazine entries1.31.92.21.51.3-1.4-1.4
Pavlov. Cond. lever-magazine prob. diff.2.23.03.3-1.8-1.81.81.5
Pavlov. Cond. response bias2.12.93.5-1.8-1.91.81.3
Time in closed arm before self-admin0.10.10.2-0.30.10.30.5
Time in closed arm after self-admin0.70.70.90.80.9-0.8-0.8
Time in open arm before self-admin0.00.00.00.20.1-0.2-0.1
Time in open arm after self-admin1.71.81.91.41.3-1.4-1.4
Bone: periosteal estimation0.30.61.40.61.2-0.80.1
Bone: periosteal perimeter0.30.41.1-0.7-0.10.51.0
Bone: post-yield work0.50.81.10.90.9-1.0-0.6
Progressive ratio test 1 active lever presses0.50.70.70.80.8-0.8-0.8
Progressive ratio test 1 breakpoint0.60.70.70.80.9-0.9-0.8
Progressive ratio test 1 inactive lever presses0.10.10.1-0.3-0.30.30.3
Progressive ratio test 2 active lever presses0.00.00.0-0.1-0.10.10.1
Progressive ratio test 2 breakpoint0.10.10.1-0.3-0.20.30.3
Progressive ratio test 2 inactive lever presses0.00.00.10.10.3-0.10.1
Incentive Sensitization - Responses0.20.30.5-0.6-0.70.60.5
Incentive Sensitization - Breakpoint0.50.60.7-0.8-0.80.80.7
Sum of active levers in priming session hrs 5-60.10.10.1-0.3-0.40.30.2
Progressive ratio1.42.32.31.51.5-1.5-1.5
Food seeking constrained by brief footshock1.92.33.0-1.5-1.71.51.2
Seeking ratio, punishment vs. effort2.84.04.6-2.0-2.22.01.7
Retroperitoneal fat weight3.012.714.13.83.4-3.6-3.5
Reaction time number correct1.12.22.51.51.3-1.6-1.6
Reaction time mean minus median0.71.71.9-1.3-1.41.31.2
Reaction time mean minus median AUC1.33.24.2-1.7-1.51.82.1
Reaction time num false alarms0.40.60.90.61.0-0.6-1.0
Reaction time num false alarms AUC0.50.81.30.61.0-0.6-1.1
Reaction time trials correct on left1.12.22.51.51.3-1.6-1.6
Reaction time trials on left1.12.12.31.51.2-1.5-1.5
Reaction time mean1.42.32.9-1.5-1.41.51.7
Reaction time mean AUC0.71.11.7-1.0-0.90.91.3
Median of all reaction times1.01.42.0-1.2-1.01.21.4
Reaction time omissions0.10.10.3-0.2-0.00.20.5
Reaction time false alarm rate0.00.10.1-0.20.30.2-0.2
Reaction time premature initiation rate0.81.11.7-1.1-1.31.10.4
Reaction time premature initiations0.10.20.4-0.2-0.60.1-0.4
Std. dev. reaction times0.71.31.7-1.1-1.11.11.3
Reaction time trials completed1.12.12.31.51.2-1.5-1.5
Reaction time trials AUC1.32.52.91.61.3-1.6-1.7
Run reversals in cocaine runway, females3.23.23.7-1.7-1.81.71.9
Run reversals in cocaine runway, males2.92.93.5-1.6-1.71.61.9
Latency to leave start box in cocaine runway0.30.30.5-0.60.00.60.7
Latency to leave start box in cocaine runway, F0.30.41.0-0.50.00.51.0
Latency to leave start box in cocaine runway, M0.00.00.1-0.00.10.0-0.4
Std. dev. time between licks in bursts1.01.42.0-1.2-0.91.21.4
Total sessions with >9 infusions0.50.50.90.71.0-0.7-0.5
Short access day 1 total inactive lever presses0.10.10.3-0.3-0.50.30.1
Short access day 10 total inactive lever presses0.10.30.60.5-0.0-0.5-0.8
Short access day 1 total infusions0.40.61.00.71.0-0.7-0.5
Short access day 10 total infusions0.30.40.50.70.7-0.7-0.5
Short access total infusions0.70.91.40.91.2-0.9-0.6
Short access day 1 locomotion0.10.10.1-0.3-0.40.30.1
Short access day 10 total locomotion0.20.31.1-0.3-1.10.30.1
Short access total locomotion0.00.00.1-0.1-0.30.1-0.0
One hour access (0.3 mA shock)0.40.40.60.70.5-0.8-0.6
Compulsive drug intake0.10.10.1-0.3-0.30.30.3
One hour access (shock baseline)0.00.00.10.20.0-0.2-0.2
Social response proportion1.31.51.6-1.1-1.31.21.2
Social responses10.713.814.9-3.8-3.93.73.5
Social time1.31.81.91.41.3-1.3-1.3
Soleus weight5.215.218.83.94.3-3.8-3.6
Bone: stiffness2.94.76.52.22.5-2.4-1.4
Tibialis anterior weight1.34.34.92.12.2-2.1-1.8
Time to tail flick, vehicle, before self-admin1.61.62.0-1.3-1.11.31.4
Time to tail flick, vehicle, after self-admin0.10.10.2-0.0-0.50.0-0.3
Time to tail flick, test, before self-admin1.31.31.9-1.2-0.91.21.4
Time to tail flick, test, after self-admin0.00.00.1-0.20.00.20.3
Delta time to tail flick, vehicle, before/after SA2.22.12.91.51.1-1.5-1.7
Delta time to tail flick, test, before/after SA0.30.30.60.50.2-0.5-0.8
Tibia length0.92.43.1-1.6-1.81.61.1
Ambulatory time before self-admin0.30.50.6-0.7-0.70.70.6
Ambulatory time after self-admin0.00.00.0-0.1-0.10.10.1
Bone: tissue strength4.24.35.61.92.4-2.3-1.6
Total heroin consumption2.53.03.2-1.7-1.81.71.7
Bone: trabecular number1.11.72.5-1.4-0.91.31.6
Bone: trabecular spacing1.31.73.31.40.7-1.1-1.8
Bone: trabecular thickness1.11.43.5-1.1-0.20.91.9
Bone: trabecular tissue density5.78.49.12.92.9-3.0-2.7
Water consumed over 24 hours0.10.20.50.30.7-0.3-0.2
Number of responses in last shaping day0.91.01.5-1.0-1.21.00.7