Hub : Genes

Col1a1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Col1a1	0.07	0.05	4.8e-06	0.04	0.05	0.04	0.03	2.2e-05	6.6e-06	1.2e-05	1.2e-04
2	Adipose	intron excision ratio	chr10_79885467_79885589	0.08	0.05	1.2e-11	0.08	0.09	0.08	0.08	5.7e-09	5.1e-10	4.4e-09	5.2e-09
3	Adipose	intron excision ratio	chr10_79883808_79885273	0.07	0.04	2.4e-10	0.07	0.08	0.07	0.07	4.7e-08	5.6e-09	3.9e-08	4.6e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.0	0.0	0.0	-0.1	-0.1	0.1
Area under the delay curve	0.1	0.1	0.1	-0.4	-0.3	0.3
BMI with tail	7.1	23.2	29.5	-5.4	-4.5	4.5
BMI without tail	4.1	8.5	8.9	-2.8	-3.0	3.0
Body weight	1.6	6.6	8.2	-2.9	-2.4	2.4
Weight adjusted by age	0.3	0.4	0.6	-0.7	-0.5	0.5
Bone surface	0.2	0.3	0.4	-0.6	-0.5	0.5
Bone volume	0.0	0.0	0.0	-0.1	0.2	-0.2
Breakpoint value in progressive ratio session	3.1	3.4	3.6	-1.7	-1.9	1.9
Number of licking bursts	0.5	0.6	1.2	1.1	0.5	-0.6
Context. condit. distance diff. score	0.1	0.1	0.1	0.1	0.3	-0.3
Locomotion velocity, session 1	0.5	0.6	0.7	-0.7	-0.8	0.8
Locomotion distance, session 1	0.2	0.2	0.4	-0.1	-0.6	0.6
Locomotion velocity, session 2	0.0	0.0	0.0	-0.1	-0.0	0.0
Locomotion distance, session 2	0.4	0.5	0.8	-0.1	-0.9	0.9
Locomotion velocity, session 3	0.2	0.2	0.5	-0.7	-0.3	0.3
Locomotion distance, session 3	0.2	0.2	0.3	-0.4	-0.5	0.5
Stereotopy head waving bouts, day 3	1.3	1.6	1.9	1.0	1.4	-1.4
Stereotopy head waving duration, day 3	1.8	2.2	2.6	1.2	1.6	-1.6
Locomotion velocity, session 7	0.0	0.0	0.1	0.3	0.1	-0.1
Locomotion distance, session 7	1.8	2.3	3.8	1.9	1.2	-1.2
Stereotopy head waving bouts, day 7	0.7	0.8	1.3	-1.1	-0.8	0.8
Stereotopy head waving duration, day 7	0.2	0.3	0.6	-0.7	-0.4	0.4
Locomotion velocity, session 8	1.7	2.0	2.6	-1.6	-1.3	1.3
Locomotion distance, session 8	0.6	0.9	1.0	-0.8	-1.0	1.0
Degree of sensitization distance	1.9	1.9	2.3	1.5	1.3	-1.3
Degree of sensitization stereotypy	1.1	1.2	1.3	-1.1	-1.1	1.1
Conditioned locomotion	0.6	0.6	0.7	0.7	0.9	-0.9
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.5	-0.2	0.2
Cocaine response after cond. not corrected	0.0	0.0	0.0	0.1	0.2	-0.2
Cocaine response before conditioning	0.8	1.0	1.6	1.3	0.8	-0.8
Saline control response	0.1	0.1	0.2	-0.1	-0.5	0.5
Bone: connectivity density	0.8	1.3	1.3	-1.1	-1.1	1.1
Bone: cortical apparent density	4.9	6.4	8.2	2.9	2.3	-2.3
Bone: cortical area	0.0	0.0	0.0	-0.2	-0.1	0.2
Bone: cortical porosity	0.2	0.2	0.2	-0.5	-0.4	0.4
Bone: cortical porosity	0.0	0.0	0.0	0.1	0.1	-0.1
Bone: cortical thickness	1.1	1.8	1.9	1.3	1.4	-1.3
Bone: cortical thickness	0.9	1.0	1.5	1.2	0.9	-0.9
Bone: cortical tissue density	4.9	6.4	8.3	2.9	2.3	-2.3
Condit. Reinf. active minus inactive responses	0.9	1.0	1.3	-0.8	-1.1	1.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.0	-0.1	0.1
Condit. Reinf. active responses	1.4	1.7	1.9	-1.1	-1.4	1.4
Condit. Reinf. inactive responses	0.9	1.1	1.4	-0.8	-1.2	1.2
Incentive salience index mean	1.4	1.7	2.1	-0.9	-1.5	1.5
Condit. Reinf. lever presses	0.9	1.2	1.7	-0.6	-1.3	1.3
Condit. Reinf. active minus inactive responses	0.5	0.6	0.8	-0.5	-0.9	0.9
Condit. Reinf. active-inactive response ratio	1.3	1.3	1.8	-0.7	-1.4	1.3
Condit. Reinf. active responses	0.2	0.3	0.4	-0.4	-0.7	0.7
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.4	0.5	-0.5
Condit. Reinf. lever presses	1.2	1.6	1.7	-1.3	-1.2	1.3
Condit. Reinf. lever reinforcers received	0.4	0.6	0.7	-0.6	-0.9	0.9
Conditioned reinforcement - actives	1.0	1.0	1.2	-0.8	-1.1	1.1
Conditioned reinforcement - inactives	1.3	1.4	1.9	1.4	1.1	-1.1
Conditioned locomotion	0.1	0.2	0.2	-0.3	-0.5	0.5
Patch foraging indifference point 0 sec	0.4	0.6	1.1	-1.0	-0.6	0.6
Patch foraging indifference point AUC	0.4	0.5	0.7	-0.8	-0.6	0.6
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.0	-0.1	0.1
Delay disc. indifference point, 16s delay	0.5	0.5	0.9	-0.9	-0.6	0.6
Delay disc. indifference point, 2s delay	1.1	1.2	1.3	1.1	1.1	-1.1
Delay disc. indifference point, 24s delay	1.7	1.6	1.8	-1.1	-1.3	1.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.3	0.3	-0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.3	0.2	-0.2
Indifference point function ln k	0.3	0.5	0.7	0.8	0.6	-0.6
Indifference point function log k	0.3	0.5	0.7	0.8	0.6	-0.6
Patch foraging total patch changes 0 sec	0.3	0.6	1.0	-1.0	-0.6	0.6
Patch foraging total patch changes 12 sec	0.2	0.2	0.2	-0.5	-0.4	0.4
Patch foraging total patch changes 18 sec	0.8	1.0	1.8	-1.3	-0.8	0.8
Patch foraging total patch changes 24 sec	0.5	0.6	1.0	-1.0	-0.7	0.7
Patch foraging total patch changes 6 sec	2.1	3.1	4.2	-2.1	-1.6	1.6
Patch foraging time to switch 0 sec	0.1	0.2	0.3	0.6	0.4	-0.4
Patch foraging water rate 0 sec	0.1	0.2	0.4	-0.6	-0.3	0.3
Patch foraging water rate 12 sec	1.1	1.7	2.2	-1.5	-1.2	1.2
Patch foraging water rate 18 sec	0.0	0.0	0.1	0.2	0.2	-0.2
Patch foraging water rate 24 sec	0.1	0.1	0.3	-0.5	-0.3	0.3
Patch foraging water rate 6 sec	2.1	3.0	3.2	-1.6	-1.8	1.8
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.2	0.1	-0.1
Distance traveled before self-admin	2.4	2.5	3.1	-1.1	-1.8	1.8
Distance traveled after self-admin	1.2	1.3	1.6	-0.9	-1.2	1.2
Extensor digitorum longus weight	1.6	6.3	9.8	-3.1	-2.1	2.2
Bone: elastic displacement	0.2	0.2	0.2	-0.5	-0.5	0.5
Bone: elastic work	0.1	0.2	0.2	-0.4	-0.4	0.4
Bone: endosteal estimation	0.8	1.8	2.0	-1.4	-1.3	1.3
Bone: endosteal perimeter	1.3	2.7	3.2	-1.8	-1.6	1.6
Epididymis fat weight	0.5	1.1	1.1	-1.1	-1.0	1.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.2	0.0	-0.0
Delta time in open arm before/after self-admin	0.3	0.2	0.3	0.5	0.5	-0.5
Diff in mean of infusions in LGA sessions	4.4	4.8	5.4	-2.0	-2.3	2.3
Delay discount exponential model param	0.1	0.1	0.2	0.4	0.4	-0.4
Extinction: sum of active levers before priming	0.8	0.8	0.9	-1.0	-0.9	0.9
Active lever presses in extinction session 6	0.7	0.7	0.8	-0.9	-0.8	0.8
Bone: final force	0.7	1.2	1.6	1.3	1.0	-1.0
Bone: final moment	0.6	1.0	1.3	1.1	0.9	-0.9
Food consumed during 24 hour testing period	1.4	1.7	1.9	-1.1	-1.4	1.4
Glucose	6.7	10.1	10.7	3.0	3.3	-3.3
Heart weight	0.1	0.2	0.3	-0.6	-0.3	0.3
Delay discount hyperbolic model param	0.0	0.0	0.0	0.1	0.1	-0.1
Intermittent access intake day 1-15 change	5.8	5.7	6.2	-2.5	-2.3	2.3
Intermittent access intake escalation	5.4	5.3	5.8	-2.4	-2.2	2.3
Intermittent access intake escalation 2	7.5	7.5	7.7	-2.8	-2.7	2.7
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	0.6	0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	-0.2	0.3	-0.2
Intermitt. access escalation Index	0.0	0.0	0.0	-0.1	-0.2	0.2
Intermittent access day 1 total infusions	2.8	3.3	4.0	2.0	1.7	-1.7
Intermittent access day 15 total infusions	0.6	0.6	0.8	-0.7	-0.9	0.9
Intermittent access terminal intake (last 3 days)	0.7	0.8	0.8	-0.8	-0.9	0.9
Intermittent access total infusions	0.1	0.1	0.2	0.4	0.3	-0.3
Intermittent access day 1 locomotion	2.1	2.2	3.0	1.7	1.3	-1.3
Intermittent access day 15 total locomotion	0.2	0.2	0.2	-0.4	-0.5	0.5
Intermittent access total locomotion	0.1	0.1	0.2	0.4	0.2	-0.2
Intermittent access standard deviation	6.0	6.3	7.4	-2.7	-2.4	2.4
Left kidney weight	0.4	1.2	1.3	1.1	1.1	-1.1
Right kidney weight	0.1	0.3	0.4	0.2	0.6	-0.6
Cocaine induced anxiety	2.0	2.3	2.5	-1.4	-1.6	1.6
Post-drug Anxiety	1.7	1.9	2.3	-1.1	-1.5	1.5
Baseline Anxiety	0.1	0.1	0.1	0.1	0.3	-0.3
Tail length	1.2	3.6	6.5	2.6	1.5	-1.5
Length with tail	1.6	6.0	7.0	2.6	2.3	-2.3
Length without tail	1.2	2.7	3.2	1.3	1.8	-1.8
Times rat made contact with spout	0.2	0.2	0.4	0.6	0.3	-0.3
Lifetime Intake	0.6	0.6	0.8	0.9	0.7	-0.7
Liver weight, left	0.0	0.0	0.0	0.1	0.0	-0.0
Liver weight, right	0.2	0.3	0.4	0.4	0.6	-0.6
Locomotor activity	0.1	0.2	0.2	-0.1	-0.5	0.5
Locomotor testing distance	0.1	0.1	0.2	0.1	-0.4	0.4
Locomotor testing rearing	0.3	0.5	0.7	-0.3	-0.8	0.8
Locomotion in novel chamber	0.7	0.9	1.1	-0.7	-1.0	1.0
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.3	0.4	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.3	0.6	-0.8	-0.3	0.4
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	0.8	0.4	-0.4
Time >=10cm from walls, locomotor time 1	0.4	0.5	0.6	-0.3	-0.8	0.8
Bouts of movement, locomotor time 1	0.8	0.9	1.1	0.7	1.0	-1.0
Total resting periods, locomotor time 1	1.1	1.2	1.4	0.9	1.2	-1.2
Rest time, locomotor task time 1	0.4	0.5	0.5	0.7	0.7	-0.7
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.0	-0.4	0.4
Vertical activity count, locomotor time 1	2.6	2.7	2.8	-1.6	-1.7	1.7
Time >=10cm from walls, locomotor time 2	0.9	1.0	1.7	1.3	0.8	-0.8
Bouts of movement, locomotor time 2	0.5	0.5	0.5	-0.7	-0.7	0.7
Total resting periods, locomotor time 2	0.6	0.6	0.7	-0.7	-0.8	0.8
Rest time, locomotor task time 2	0.3	0.3	0.4	0.6	0.5	-0.5
Distance moved, locomotor task time 2	1.1	1.3	1.4	1.1	1.2	-1.2
Vertical activity count, locomotor time 2	0.3	0.3	0.4	-0.6	-0.6	0.6
Light reinforcement 1	1.4	2.5	2.7	-1.5	-1.6	1.6
Light reinforcement 2	0.4	0.5	0.6	-0.5	-0.8	0.8
Bone: marrow area	0.8	1.8	2.0	-1.4	-1.3	1.3
Bone: maximum diameter	1.1	2.1	2.2	-1.5	-1.4	1.4
Bone: maximum force	0.2	0.3	0.3	0.6	0.6	-0.6
Bone: maximum moment	0.2	0.3	0.4	0.6	0.6	-0.6
Mean time between licks in bursts	0.1	0.2	0.3	0.0	0.5	-0.5
Mean num. licks in bursts	0.1	0.1	0.2	-0.4	-0.1	0.1
Cd content in liver	1.3	1.4	1.8	-0.9	-1.3	1.3
Co content in liver	0.2	0.2	0.2	-0.3	-0.5	0.5
Cu content in liver	0.9	1.1	1.7	-0.4	-1.3	1.3
Fe content in liver	0.3	0.4	0.7	0.9	0.4	-0.4
K content in liver	3.3	3.2	3.3	1.8	1.8	-1.8
Mg content in liver	2.7	2.8	3.2	1.8	1.6	-1.6
Mn content in liver	1.1	1.2	1.5	-0.8	-1.2	1.2
Na content in liver	0.7	0.8	0.8	0.9	0.9	-0.9
Rb content in liver	0.1	0.1	0.2	0.5	0.3	-0.3
Se content in liver	0.9	1.1	1.3	1.1	1.0	-1.0
Sr content in liver	0.1	0.1	0.1	0.1	0.3	-0.3
Zn content in liver	0.1	0.1	0.3	0.6	0.2	-0.2
Bone: minimum diameter	0.2	0.3	0.4	0.5	0.6	-0.6
Time in familiar zone, hab. session 1	1.1	1.0	1.5	1.2	0.9	-0.9
Time in novel zone, hab. session 1	0.5	0.5	1.1	-1.0	-0.5	0.5
Total zone transitions, hab. session 1	2.0	2.8	3.5	-1.2	-1.9	1.9
Total locomotion distance, hab. session 1	1.6	2.2	2.8	-1.1	-1.7	1.7
Locomotion velocity, hab. session 1	1.0	1.4	1.8	-0.7	-1.3	1.3
Time in familiar zone, hab. session 2	1.4	1.4	1.7	-1.3	-1.1	1.1
Time in novel zone, hab. session 2	2.1	2.1	2.5	1.6	1.4	-1.4
Total zone transitions, hab. session 2	0.6	0.7	1.0	-0.4	-1.0	1.0
Total locomotion distance, hab. session 2	0.2	0.3	0.4	-0.4	-0.6	0.6
Locomotion velocity, hab. session 2	0.1	0.2	0.2	-0.3	-0.5	0.5
Novel to familiar place preference ratio	0.3	0.3	0.4	-0.4	-0.7	0.7
Novelty place preference	0.1	0.1	0.2	-0.1	-0.4	0.4
Time in novel zone, NPP test	0.0	0.0	0.1	0.3	-0.0	0.0
Total zone transitions, NPP test	0.2	0.2	0.3	0.3	-0.5	0.5
Total locomotion distance, NPP test	0.0	0.1	0.1	0.3	-0.2	0.2
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.0	-0.5	0.5
Intraocular pressure	0.5	0.6	0.8	-0.6	-0.9	0.9
Delta distance traveled before/after self-admin	0.1	0.2	0.2	0.1	0.5	-0.5
Delta ambulatory time before/after self-admin	0.3	0.4	0.5	0.4	0.7	-0.7
Parametrial fat weight	0.5	1.1	1.6	1.3	0.9	-0.9
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.1	0.7	-0.7
Pavlov. Cond. magazine entry latency	0.6	0.8	1.0	-0.5	-1.0	1.0
Pavlov. Cond. change in total contacts	0.9	0.9	1.3	-0.3	-1.2	1.1
Pavlov. Cond. index score	0.5	0.7	1.0	-0.2	-1.0	1.0
Pavlov. Cond. latency score	0.3	0.3	0.5	0.1	-0.7	0.7
Pavlov. Cond. lever contacts	0.3	0.3	0.4	0.2	-0.7	0.6
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	0.4	1.0	-1.0
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.2	0.0	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.0	-0.2	-1.0	1.0
Pavlov. Cond. response bias	1.5	1.8	2.3	-0.9	-1.5	1.5
Pavlov. Cond. lever latency	0.3	0.5	1.0	1.0	0.4	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	-0.4	-0.1	0.1
Pavlov. Cond. change in total contacts	0.5	0.7	1.2	-1.1	-0.7	0.7
Pavlov. Cond. index score	0.4	0.5	1.0	-1.0	-0.4	0.5
Pavlov. Cond. latency score	0.2	0.3	0.6	-0.8	-0.3	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	-0.1	0.1
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.0	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.5	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	-1.0	-0.5	0.5
Pavlov. Cond. response bias	0.0	0.1	0.1	-0.2	0.3	-0.2
Time in closed arm before self-admin	0.1	0.1	0.1	-0.2	0.3	-0.2
Time in closed arm after self-admin	0.1	0.1	0.2	-0.4	0.2	-0.2
Time in open arm before self-admin	0.0	0.0	0.0	0.2	-0.1	0.1
Time in open arm after self-admin	0.0	0.0	0.0	0.1	-0.1	0.1
Bone: periosteal estimation	0.2	0.5	0.6	-0.8	-0.7	0.7
Bone: periosteal perimeter	0.9	1.4	1.7	-1.3	-1.1	1.1
Bone: post-yield work	0.1	0.1	0.3	-0.5	-0.3	0.3
Progressive ratio test 1 active lever presses	1.1	1.1	2.0	1.4	0.9	-0.9
Progressive ratio test 1 breakpoint	1.5	1.6	2.6	1.6	1.1	-1.1
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.2	1.1	0.9	-0.9
Progressive ratio test 2 active lever presses	0.6	0.6	0.9	-0.4	-0.9	0.9
Progressive ratio test 2 breakpoint	1.0	1.1	1.4	-0.7	-1.2	1.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	-0.2	-0.4	0.4
Incentive Sensitization - Responses	3.5	3.6	3.9	-1.7	-2.0	2.0
Incentive Sensitization - Breakpoint	3.7	3.8	4.2	-1.8	-2.0	2.0
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.4	0.1	-0.1
Progressive ratio	0.9	1.1	1.2	-0.9	-1.1	1.1
Food seeking constrained by brief footshock	0.1	0.2	0.2	0.5	0.4	-0.4
Seeking ratio, punishment vs. effort	2.8	3.4	3.5	1.9	1.8	-1.8
Retroperitoneal fat weight	0.0	0.1	0.2	-0.4	-0.3	0.3
Reaction time number correct	0.4	0.6	0.8	0.5	0.9	-0.9
Reaction time mean minus median	0.1	0.1	0.1	-0.2	-0.4	0.4
Reaction time mean minus median AUC	0.1	0.1	0.1	-0.1	-0.3	0.3
Reaction time num false alarms	0.8	1.0	1.2	-0.8	-1.1	1.1
Reaction time num false alarms AUC	0.6	0.9	1.0	-0.7	-1.0	1.0
Reaction time trials correct on left	0.4	0.6	0.8	0.5	0.9	-0.9
Reaction time trials on left	0.4	0.5	0.7	0.4	0.8	-0.8
Reaction time mean	0.2	0.2	0.3	-0.6	-0.4	0.4
Reaction time mean AUC	0.2	0.2	0.2	-0.5	-0.5	0.5
Median of all reaction times	0.1	0.2	0.3	-0.5	-0.4	0.4
Reaction time omissions	1.2	1.6	1.8	-1.2	-1.3	1.3
Reaction time false alarm rate	1.1	1.5	1.9	-0.9	-1.4	1.4
Reaction time premature initiation rate	0.1	0.2	0.2	-0.2	-0.5	0.5
Reaction time premature initiations	0.0	0.0	0.0	-0.1	-0.1	0.1
Std. dev. reaction times	0.0	0.0	0.0	0.2	0.2	-0.2
Reaction time trials completed	0.4	0.5	0.7	0.4	0.8	-0.8
Reaction time trials AUC	0.5	0.7	0.8	0.6	0.9	-0.9
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.2	-0.0	0.0
Run reversals in cocaine runway, males	0.3	0.3	0.3	-0.5	-0.5	0.5
Latency to leave start box in cocaine runway	0.7	0.7	1.8	-1.3	-0.4	0.4
Latency to leave start box in cocaine runway, F	0.5	0.5	0.8	-0.1	0.9	-0.9
Latency to leave start box in cocaine runway, M	7.2	6.9	7.6	-2.8	-2.6	2.6
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.1	-0.0	0.0
Total sessions with >9 infusions	1.1	1.2	1.4	1.2	1.0	-1.0
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.3	0.1	-0.1
Short access day 10 total inactive lever presses	3.1	3.5	3.9	-2.0	-1.8	1.8
Short access day 1 total infusions	3.0	3.2	3.3	1.8	1.8	-1.8
Short access day 10 total infusions	1.9	2.2	2.4	1.5	1.4	-1.4
Short access total infusions	2.1	2.3	2.4	1.5	1.6	-1.5
Short access day 1 locomotion	0.1	0.1	0.1	0.3	0.3	-0.3
Short access day 10 total locomotion	0.9	1.1	1.4	1.2	0.9	-1.0
Short access total locomotion	1.7	1.8	1.8	1.3	1.4	-1.4
One hour access (0.3 mA shock)	1.1	1.2	1.4	-0.9	-1.2	1.2
Compulsive drug intake	0.2	0.2	0.5	0.7	0.2	-0.2
One hour access (shock baseline)	2.1	2.4	2.5	-1.5	-1.6	1.6
Social response proportion	0.3	0.3	0.7	0.8	0.4	-0.4
Social responses	1.1	1.4	1.6	-1.0	-1.3	1.2
Social time	0.9	1.2	1.5	-0.7	-1.2	1.2
Soleus weight	0.2	0.6	0.8	0.4	0.9	-0.9
Bone: stiffness	0.8	1.3	1.5	1.2	1.1	-1.1
Tibialis anterior weight	1.9	6.5	6.6	-2.6	-2.5	2.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	0.8	0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.1	0.3	-0.3
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.0	0.6	-0.6
Time to tail flick, test, after self-admin	2.5	2.6	2.8	1.5	1.7	-1.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.0	0.3	-0.3
Delta time to tail flick, test, before/after SA	1.5	1.4	2.0	1.4	1.0	-1.0
Tibia length	1.2	3.3	3.8	1.5	1.9	-1.9
Ambulatory time before self-admin	4.2	4.3	5.1	-1.7	-2.2	2.2
Ambulatory time after self-admin	1.1	1.3	1.4	-1.0	-1.2	1.2
Bone: tissue strength	2.1	2.1	2.4	1.2	1.6	-1.5
Total heroin consumption	0.4	0.4	0.5	-0.6	-0.7	0.7
Bone: trabecular number	0.2	0.3	0.3	-0.4	-0.6	0.6
Bone: trabecular spacing	1.0	1.3	1.5	-1.0	-1.2	1.2
Bone: trabecular thickness	0.8	0.9	1.3	0.3	1.2	-1.1
Bone: trabecular tissue density	1.0	1.5	1.6	1.1	1.3	-1.3
Water consumed over 24 hours	0.0	0.1	0.1	-0.2	-0.3	0.3
Number of responses in last shaping day	0.5	0.5	1.0	-1.0	-0.5	0.5