Hub : Genes

Clasrp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL isoform ratio XM_063271795.1 0.15 0.09 1.4e-03 0.15 0.1 0.1 0.11 1.5e-04 2.3e-03 1.9e-03 1.7e-03
2 Adipose isoform ratio NM_001024294.2 0.08 0.05 1.9e-08 0.07 0.07 0.06 0.06 8.2e-08 4.8e-08 1.0e-07 1.6e-07
3 Liver gene expression Clasrp 0.03 0.02 1.3e-03 0.02 0.02 0.01 0.01 3.6e-03 2.2e-03 1.2e-02 9.2e-03
4 IL gene expression Clasrp 0.15 0.1 7.1e-03 0.05 0.07 0.11 0.09 2.3e-02 1.0e-02 1.5e-03 3.9e-03
5 Adipose isoform ratio XM_063271795.1 0.11 0.08 9.3e-09 0.07 0.07 0.07 0.07 3.4e-08 2.7e-08 1.7e-08 5.9e-08
6 Adipose alternative TSS XM_063271795.1 0.06 0.04 3.0e-07 0.06 0.05 0.05 0.05 2.0e-07 4.7e-06 2.2e-06 1.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density0.00.10.2-0.2-0.2-0.30.4-0.3-0.3
Area under the delay curve1.52.24.01.61.21.1-0.52.02.0
BMI with tail0.72.64.1-1.4-1.6-1.62.0-1.5-1.5
BMI without tail0.31.62.0-1.4-1.3-1.31.4-1.0-1.0
Body weight1.46.18.1-2.2-2.5-2.52.8-2.4-2.3
Weight adjusted by age0.00.00.00.00.00.1-0.1-0.1-0.1
Bone surface0.40.91.1-0.8-0.9-0.91.1-1.0-0.9
Bone volume0.40.71.0-0.7-0.8-0.91.0-0.9-0.9
Breakpoint value in progressive ratio session1.22.22.81.71.51.5-1.01.61.6
Number of licking bursts0.92.83.5-1.5-1.8-1.81.9-1.5-1.5
Context. condit. distance diff. score0.20.30.4-0.4-0.5-0.50.6-0.5-0.6
Locomotion velocity, session 10.00.00.10.40.10.10.1-0.1-0.1
Locomotion distance, session 10.20.30.5-0.4-0.4-0.50.5-0.7-0.7
Locomotion velocity, session 20.60.81.1-1.0-0.9-0.90.5-0.9-0.9
Locomotion distance, session 20.40.50.7-0.9-0.6-0.60.4-0.9-0.9
Locomotion velocity, session 30.10.10.2-0.5-0.2-0.2-0.0-0.3-0.3
Locomotion distance, session 31.31.42.90.81.31.4-1.70.80.8
Stereotopy head waving bouts, day 30.20.20.5-0.7-0.5-0.40.1-0.3-0.4
Stereotopy head waving duration, day 30.60.81.0-1.0-1.0-0.90.9-0.7-0.7
Locomotion velocity, session 70.00.00.10.10.30.3-0.1-0.00.0
Locomotion distance, session 70.10.20.4-0.3-0.3-0.40.6-0.5-0.4
Stereotopy head waving bouts, day 70.70.81.1-1.0-0.9-0.80.6-1.1-1.1
Stereotopy head waving duration, day 70.50.60.7-0.8-0.8-0.80.7-0.8-0.8
Locomotion velocity, session 80.20.20.40.10.40.4-0.70.60.5
Locomotion distance, session 80.10.20.3-0.4-0.2-0.30.3-0.5-0.5
Degree of sensitization distance1.31.43.4-0.8-1.2-1.31.9-0.8-0.8
Degree of sensitization stereotypy0.91.01.3-1.0-0.9-0.90.7-1.2-1.1
Conditioned locomotion0.50.62.20.20.80.9-1.50.20.1
Cocaine response after cond. corrected0.50.81.3-0.9-0.7-0.70.5-1.1-1.2
Cocaine response after cond. not corrected1.21.83.0-1.4-1.1-1.00.8-1.7-1.7
Cocaine response before conditioning1.01.21.8-1.3-1.0-1.00.6-1.3-1.3
Saline control response1.82.52.8-1.6-1.7-1.71.6-1.4-1.4
Bone: connectivity density0.00.00.1-0.1-0.1-0.10.3-0.0-0.0
Bone: cortical apparent density0.00.00.10.10.20.10.00.30.3
Bone: cortical area1.42.32.6-1.4-1.6-1.61.5-1.5-1.4
Bone: cortical porosity1.31.54.40.61.21.3-2.10.60.6
Bone: cortical porosity0.60.72.40.20.80.9-1.60.30.3
Bone: cortical thickness0.50.81.0-1.0-1.0-1.00.8-0.8-0.8
Bone: cortical thickness1.21.51.7-1.3-1.2-1.21.0-1.3-1.3
Bone: cortical tissue density0.10.10.20.20.30.3-0.10.40.4
Condit. Reinf. active minus inactive responses0.50.60.7-0.7-0.7-0.70.9-0.8-0.8
Condit. Reinf. active-inactive response ratio0.60.71.0-0.7-0.7-0.71.0-0.9-0.9
Condit. Reinf. active responses0.40.50.6-0.6-0.6-0.60.7-0.8-0.8
Condit. Reinf. inactive responses0.00.00.0-0.10.00.00.1-0.1-0.0
Incentive salience index mean0.20.30.5-0.5-0.4-0.40.3-0.7-0.7
Condit. Reinf. lever presses0.00.10.1-0.1-0.00.0-0.3-0.4-0.4
Condit. Reinf. active minus inactive responses0.10.10.3-0.4-0.3-0.30.2-0.5-0.5
Condit. Reinf. active-inactive response ratio0.40.71.3-0.9-0.5-0.50.2-1.1-1.2
Condit. Reinf. active responses0.10.20.30.40.40.4-0.50.50.5
Condit. Reinf. inactive responses0.91.32.21.01.01.0-0.81.51.5
Condit. Reinf. lever presses0.30.51.2-0.4-0.7-0.81.1-0.5-0.5
Condit. Reinf. lever reinforcers received0.20.30.40.40.50.5-0.70.50.5
Conditioned reinforcement - actives0.41.42.3-1.5-1.4-1.30.9-1.0-1.0
Conditioned reinforcement - inactives0.10.30.5-0.7-0.6-0.6-0.3-0.5-0.4
Conditioned locomotion1.82.63.0-1.7-1.6-1.61.3-1.7-1.7
Patch foraging indifference point 0 sec0.20.60.8-0.8-0.8-0.80.6-0.9-0.9
Patch foraging indifference point AUC1.33.14.1-2.0-1.9-1.81.6-1.6-1.6
Delay disc. indifference point, 0s delay1.61.82.01.31.31.4-1.41.31.3
Delay disc. indifference point, 16s delay1.11.63.41.20.80.7-0.01.81.8
Delay disc. indifference point, 2s delay2.93.35.72.41.61.6-0.92.02.0
Delay disc. indifference point, 24s delay0.40.72.6-0.3-0.7-0.71.6-0.5-0.5
Delay disc. indifference point, 4s delay0.10.10.10.20.10.1-0.00.40.4
Delay disc. indifference point, 8s delay1.42.44.31.61.21.2-0.72.12.1
Indifference point function ln k0.30.80.90.91.00.9-0.70.80.9
Indifference point function log k0.30.80.90.91.00.9-0.70.80.9
Patch foraging total patch changes 0 sec0.41.31.4-1.2-1.1-1.11.1-1.2-1.2
Patch foraging total patch changes 12 sec0.70.91.3-1.1-1.0-0.90.6-1.0-1.1
Patch foraging total patch changes 18 sec1.63.74.3-1.8-1.9-2.02.1-1.9-1.9
Patch foraging total patch changes 24 sec0.20.60.8-0.8-0.7-0.70.9-0.7-0.7
Patch foraging total patch changes 6 sec1.62.63.8-2.0-1.7-1.61.3-1.6-1.6
Patch foraging time to switch 0 sec1.45.46.92.62.32.3-2.22.32.3
Patch foraging water rate 0 sec1.55.87.1-2.7-2.4-2.42.3-2.4-2.4
Patch foraging water rate 12 sec0.20.61.0-0.8-0.7-0.71.0-0.7-0.7
Patch foraging water rate 18 sec0.30.61.3-0.8-0.8-0.81.2-0.4-0.4
Patch foraging water rate 24 sec0.71.01.3-1.1-1.0-1.01.1-0.8-0.8
Patch foraging water rate 6 sec1.52.24.0-1.3-1.5-1.52.0-1.2-1.1
Seeking ratio, delayed vs. immediate footshock1.82.63.01.41.71.7-1.31.71.7
Distance traveled before self-admin0.10.20.3-0.3-0.4-0.40.2-0.5-0.5
Distance traveled after self-admin0.20.41.10.40.60.6-1.00.60.5
Extensor digitorum longus weight2.18.310.3-2.6-3.0-3.03.2-2.7-2.7
Bone: elastic displacement1.01.21.50.91.21.2-1.21.01.0
Bone: elastic work0.00.00.1-0.20.20.2-0.4-0.1-0.1
Bone: endosteal estimation0.00.00.10.20.20.10.0-0.0-0.0
Bone: endosteal perimeter0.00.00.10.2-0.2-0.20.3-0.2-0.1
Epididymis fat weight0.21.11.41.01.01.0-0.91.21.2
Delta time in closed arm before/after self-admin0.10.10.30.2-0.0-0.00.50.20.2
Delta time in open arm before/after self-admin0.20.20.80.20.30.3-0.90.30.3
Diff in mean of infusions in LGA sessions0.81.41.71.31.21.1-0.81.31.3
Delay discount exponential model param1.21.62.9-1.4-0.9-0.90.3-1.7-1.7
Extinction: sum of active levers before priming0.20.20.40.30.50.6-0.70.30.3
Active lever presses in extinction session 60.20.20.5-0.2-0.4-0.40.4-0.7-0.7
Bone: final force0.30.50.8-0.6-0.7-0.70.6-0.9-0.8
Bone: final moment0.40.71.0-0.7-0.8-0.80.7-1.0-1.0
Food consumed during 24 hour testing period2.65.36.22.42.52.5-1.62.32.3
Glucose0.40.70.80.90.80.8-0.70.90.9
Heart weight1.82.83.1-1.7-1.8-1.71.6-1.6-1.7
Delay discount hyperbolic model param1.11.52.7-1.4-0.9-0.80.2-1.6-1.6
Intermittent access intake day 1-15 change0.10.40.9-0.4-0.7-0.70.9-0.5-0.5
Intermittent access intake escalation0.10.51.0-0.5-0.7-0.81.0-0.6-0.5
Intermittent access intake escalation 20.00.00.0-0.1-0.1-0.00.2-0.1-0.1
Intermitt. access day 1 inactive lever presses0.00.00.2-0.0-0.1-0.2-0.4-0.00.0
Intermitt. access day 15 inactive lever presses0.00.10.2-0.0-0.4-0.50.2-0.10.0
Intermitt. access escalation Index0.00.10.30.50.40.4-0.30.30.3
Intermittent access day 1 total infusions0.51.42.3-1.5-1.4-1.40.8-0.8-0.8
Intermittent access day 15 total infusions0.51.11.7-1.0-1.3-1.31.2-0.6-0.6
Intermittent access terminal intake (last 3 days)0.81.42.0-1.2-1.4-1.41.4-0.8-0.8
Intermittent access total infusions2.22.63.3-1.7-1.8-1.81.7-1.3-1.3
Intermittent access day 1 locomotion0.10.10.4-0.6-0.4-0.4-0.1-0.3-0.3
Intermittent access day 15 total locomotion0.00.10.2-0.5-0.5-0.50.30.0-0.0
Intermittent access total locomotion1.11.32.0-1.4-1.3-1.31.1-0.8-0.8
Intermittent access standard deviation0.00.20.30.50.40.4-0.30.40.4
Left kidney weight3.124.728.2-5.3-4.9-4.94.4-5.1-5.2
Right kidney weight3.323.024.5-4.9-4.8-4.74.4-4.9-4.9
Cocaine induced anxiety0.10.30.70.60.30.3-0.10.80.8
Post-drug Anxiety0.10.10.10.30.10.1-0.20.30.4
Baseline Anxiety0.00.10.3-0.00.20.2-0.6-0.2-0.2
Tail length0.21.01.2-1.0-1.1-1.10.9-0.9-0.9
Length with tail0.41.71.9-1.1-1.3-1.31.3-1.4-1.3
Length without tail0.52.94.2-1.1-1.6-1.72.1-1.8-1.8
Times rat made contact with spout0.10.20.5-0.20.00.00.7-0.4-0.4
Lifetime Intake1.82.32.9-1.7-1.7-1.71.5-1.2-1.2
Liver weight, left1.11.83.1-1.8-1.5-1.41.0-1.2-1.2
Liver weight, right1.52.52.8-1.5-1.6-1.61.7-1.6-1.6
Locomotor activity1.32.02.6-1.6-1.6-1.51.1-1.2-1.2
Locomotor testing distance0.51.21.7-1.3-1.3-1.20.9-0.9-0.9
Locomotor testing rearing2.17.68.3-2.9-2.9-2.92.8-2.6-2.6
Locomotion in novel chamber0.20.20.40.40.30.3-0.10.60.7
Locomotion in novel chamber post-restriction0.41.21.41.11.21.2-1.10.90.9
Fecal boli incidents, locomotor time 10.00.00.1-0.1-0.1-0.10.3-0.0-0.0
Change in fecal boli incidents, locomotor task0.80.91.11.10.80.8-0.81.11.1
Time >=10cm from walls, locomotor time 10.00.10.1-0.3-0.2-0.20.4-0.2-0.2
Bouts of movement, locomotor time 11.72.22.71.51.41.3-1.31.61.7
Total resting periods, locomotor time 12.52.93.91.71.61.5-1.42.02.0
Rest time, locomotor task time 10.10.20.40.30.30.3-0.40.70.7
Distance moved, locomotor task time 10.10.40.9-0.5-0.4-0.30.0-0.9-0.9
Vertical activity count, locomotor time 10.00.20.40.30.40.5-0.6-0.2-0.2
Time >=10cm from walls, locomotor time 20.10.31.10.40.50.5-1.00.30.3
Bouts of movement, locomotor time 21.34.36.12.52.22.1-1.81.91.9
Total resting periods, locomotor time 20.93.75.22.32.01.9-1.71.81.8
Rest time, locomotor task time 20.10.10.5-0.10.20.2-0.70.30.2
Distance moved, locomotor task time 20.50.61.2-0.6-0.7-0.60.4-1.1-1.1
Vertical activity count, locomotor time 20.10.10.40.60.40.4-0.10.10.1
Light reinforcement 10.10.20.3-0.5-0.4-0.40.5-0.5-0.5
Light reinforcement 20.10.20.2-0.4-0.4-0.40.5-0.3-0.3
Bone: marrow area0.00.00.00.20.10.10.1-0.1-0.1
Bone: maximum diameter2.14.24.7-1.9-2.2-2.22.1-2.0-1.9
Bone: maximum force0.10.20.3-0.4-0.5-0.50.5-0.5-0.4
Bone: maximum moment0.10.30.3-0.4-0.6-0.60.5-0.6-0.5
Mean time between licks in bursts0.00.10.20.30.50.50.20.30.3
Mean num. licks in bursts0.92.33.61.31.91.9-1.51.21.2
Cd content in liver0.10.10.20.0-0.1-0.20.4-0.3-0.3
Co content in liver1.51.72.81.21.41.4-1.71.01.0
Cu content in liver0.30.40.5-0.5-0.7-0.70.6-0.6-0.6
Fe content in liver4.45.47.0-2.0-2.6-2.62.4-2.1-2.1
K content in liver0.00.00.10.1-0.1-0.1-0.4-0.1-0.1
Mg content in liver0.10.10.2-0.3-0.3-0.2-0.3-0.4-0.4
Mn content in liver0.50.50.9-0.9-0.2-0.1-0.7-0.9-0.9
Na content in liver0.00.00.1-0.1-0.3-0.20.0-0.2-0.2
Rb content in liver0.30.30.4-0.5-0.5-0.50.6-0.6-0.6
Se content in liver1.92.32.9-1.7-1.7-1.60.9-1.5-1.5
Sr content in liver0.10.10.20.20.10.2-0.40.10.1
Zn content in liver0.70.91.3-0.7-0.9-0.90.8-1.1-1.1
Bone: minimum diameter0.20.40.6-0.5-0.6-0.60.8-0.7-0.7
Time in familiar zone, hab. session 10.20.20.3-0.3-0.4-0.40.4-0.5-0.5
Time in novel zone, hab. session 10.40.40.5-0.7-0.7-0.70.7-0.6-0.6
Total zone transitions, hab. session 10.40.50.6-0.7-0.6-0.70.8-0.8-0.8
Total locomotion distance, hab. session 10.30.50.60.80.70.7-0.70.70.7
Locomotion velocity, hab. session 11.01.41.81.31.21.2-1.11.21.2
Time in familiar zone, hab. session 20.40.51.0-0.3-0.8-0.81.0-0.5-0.5
Time in novel zone, hab. session 20.00.00.10.10.30.2-0.10.20.2
Total zone transitions, hab. session 20.40.51.1-0.6-0.6-0.60.2-1.0-1.0
Total locomotion distance, hab. session 20.60.81.21.00.90.9-1.10.50.5
Locomotion velocity, hab. session 20.40.51.10.80.80.8-1.00.30.3
Novel to familiar place preference ratio1.11.41.9-1.3-1.1-1.11.4-1.1-1.1
Novelty place preference1.01.21.6-1.2-1.0-1.01.3-1.1-1.0
Time in novel zone, NPP test1.21.42.0-1.3-1.1-1.11.4-1.1-1.1
Total zone transitions, NPP test0.20.30.3-0.4-0.5-0.50.4-0.6-0.6
Total locomotion distance, NPP test0.30.40.5-0.4-0.6-0.60.7-0.7-0.6
Locomotion velocity, NPP test0.20.30.4-0.4-0.6-0.60.5-0.6-0.6
Intraocular pressure0.10.10.30.2-0.2-0.30.5-0.4-0.4
Delta distance traveled before/after self-admin2.12.32.71.41.51.5-1.41.61.6
Delta ambulatory time before/after self-admin0.40.81.00.70.90.9-0.81.01.0
Parametrial fat weight0.00.10.2-0.4-0.1-0.1-0.0-0.3-0.2
Pavlov. Cond. lever latency0.50.61.00.80.70.7-0.41.01.0
Pavlov. Cond. magazine entry latency0.30.40.6-0.2-0.6-0.60.8-0.7-0.7
Pavlov. Cond. change in total contacts0.40.40.60.70.80.7-0.80.30.3
Pavlov. Cond. index score0.30.40.8-0.5-0.6-0.60.4-0.9-0.9
Pavlov. Cond. latency score0.10.10.3-0.1-0.2-0.20.0-0.5-0.5
Pavlov. Cond. lever contacts0.40.40.8-0.6-0.6-0.60.3-0.9-0.8
Pavlov. Cond. magazine entry number0.10.20.4-0.10.30.3-0.30.60.6
Pavlov. Cond. intertrial magazine entries0.00.00.2-0.4-0.0-0.0-0.1-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.9-0.5-0.5-0.50.2-0.9-0.9
Pavlov. Cond. response bias1.31.62.2-1.0-1.2-1.21.2-1.5-1.5
Pavlov. Cond. lever latency0.00.00.10.10.20.2-0.20.30.3
Pavlov. Cond. magazine entry latency0.60.82.2-0.4-0.7-0.81.5-0.9-0.9
Pavlov. Cond. change in total contacts0.00.00.20.30.10.10.4-0.0-0.0
Pavlov. Cond. index score0.20.20.9-0.0-0.3-0.40.9-0.4-0.4
Pavlov. Cond. latency score0.10.10.50.1-0.1-0.20.7-0.2-0.2
Pavlov. Cond. lever contacts0.20.30.4-0.3-0.5-0.50.7-0.5-0.5
Pavlov. Cond. magazine entry number0.20.21.2-0.40.10.2-1.10.10.1
Pavlov. Cond. intertrial magazine entries0.10.20.7-0.10.30.4-0.90.30.3
Pavlov. Cond. lever-magazine prob. diff.0.20.41.1-0.2-0.5-0.51.0-0.6-0.6
Pavlov. Cond. response bias0.10.10.3-0.1-0.2-0.30.6-0.4-0.4
Time in closed arm before self-admin0.71.21.7-1.1-1.2-1.21.3-0.9-0.9
Time in closed arm after self-admin0.50.61.20.80.40.30.61.11.1
Time in open arm before self-admin1.01.31.91.01.21.2-1.41.01.0
Time in open arm after self-admin1.11.24.50.41.01.1-2.10.40.4
Bone: periosteal estimation0.30.60.7-0.6-0.8-0.80.9-0.9-0.8
Bone: periosteal perimeter0.30.50.7-0.5-0.8-0.80.9-0.7-0.7
Bone: post-yield work0.40.71.11.10.70.6-0.31.11.0
Progressive ratio test 1 active lever presses0.91.63.1-1.8-1.5-1.40.5-1.0-1.0
Progressive ratio test 1 breakpoint0.81.32.7-1.7-1.3-1.30.5-0.9-0.9
Progressive ratio test 1 inactive lever presses0.61.62.2-1.3-1.5-1.50.9-1.1-1.1
Progressive ratio test 2 active lever presses1.41.92.8-1.5-1.7-1.71.2-1.1-1.1
Progressive ratio test 2 breakpoint1.82.23.2-1.6-1.8-1.81.4-1.2-1.2
Progressive ratio test 2 inactive lever presses0.00.10.4-0.3-0.6-0.6-0.1-0.2-0.2
Incentive Sensitization - Responses0.82.23.0-1.1-1.6-1.71.7-1.3-1.3
Incentive Sensitization - Breakpoint0.92.02.9-1.1-1.6-1.61.7-1.3-1.2
Sum of active levers in priming session hrs 5-60.50.50.60.50.80.8-0.50.80.8
Progressive ratio0.51.52.51.31.11.0-0.51.61.6
Food seeking constrained by brief footshock5.77.18.42.42.92.9-2.72.52.5
Seeking ratio, punishment vs. effort0.41.01.80.81.11.2-1.30.60.6
Retroperitoneal fat weight0.10.20.7-0.3-0.5-0.60.8-0.2-0.2
Reaction time number correct1.86.57.8-2.8-2.6-2.62.6-2.3-2.3
Reaction time mean minus median0.00.00.10.20.0-0.00.3-0.0-0.0
Reaction time mean minus median AUC0.10.71.3-0.6-0.8-0.91.1-0.8-0.8
Reaction time num false alarms3.96.76.9-2.5-2.6-2.62.6-2.6-2.6
Reaction time num false alarms AUC2.35.45.6-2.2-2.4-2.42.2-2.4-2.3
Reaction time trials correct on left1.86.57.8-2.8-2.6-2.62.6-2.3-2.3
Reaction time trials on left1.96.57.8-2.8-2.6-2.62.6-2.4-2.3
Reaction time mean0.40.81.21.01.11.0-0.70.60.6
Reaction time mean AUC0.20.50.80.90.90.9-0.60.50.5
Median of all reaction times0.81.21.81.21.41.3-1.00.80.8
Reaction time omissions0.10.10.2-0.3-0.0-0.10.2-0.5-0.5
Reaction time false alarm rate0.20.30.4-0.3-0.6-0.60.5-0.6-0.6
Reaction time premature initiation rate0.30.50.90.60.80.9-0.90.50.5
Reaction time premature initiations0.10.40.7-0.8-0.5-0.50.4-0.8-0.8
Std. dev. reaction times0.00.10.20.40.30.3-0.10.20.2
Reaction time trials completed1.96.57.8-2.8-2.6-2.62.6-2.4-2.3
Reaction time trials AUC2.38.09.6-3.1-2.9-2.82.8-2.6-2.6
Run reversals in cocaine runway, females0.10.10.20.50.20.20.30.50.5
Run reversals in cocaine runway, males0.60.60.9-0.7-0.5-0.50.9-1.0-1.0
Latency to leave start box in cocaine runway0.50.61.9-0.6-0.7-0.81.4-0.5-0.4
Latency to leave start box in cocaine runway, F0.80.91.4-1.0-1.0-1.01.2-0.7-0.7
Latency to leave start box in cocaine runway, M0.20.20.80.1-0.2-0.30.9-0.2-0.2
Std. dev. time between licks in bursts0.00.00.1-0.3-0.1-0.1-0.3-0.2-0.2
Total sessions with >9 infusions2.43.04.4-2.1-1.9-1.81.5-1.4-1.5
Short access day 1 total inactive lever presses0.50.91.6-0.7-1.0-1.01.2-0.8-0.8
Short access day 10 total inactive lever presses0.10.81.61.21.00.9-0.60.70.8
Short access day 1 total infusions0.71.52.4-1.6-1.4-1.30.9-0.9-1.0
Short access day 10 total infusions1.93.14.6-2.1-1.9-1.91.5-1.5-1.5
Short access total infusions1.11.62.6-1.6-1.4-1.41.0-1.0-1.0
Short access day 1 locomotion1.83.04.1-2.0-1.8-1.81.9-1.4-1.4
Short access day 10 total locomotion0.00.00.1-0.10.10.1-0.1-0.3-0.3
Short access total locomotion0.20.30.9-1.0-0.5-0.40.1-0.5-0.6
One hour access (0.3 mA shock)0.10.10.3-0.2-0.5-0.50.4-0.3-0.2
Compulsive drug intake0.40.61.1-0.6-0.6-0.5-0.7-1.0-1.0
One hour access (shock baseline)0.61.63.3-1.1-1.3-1.31.8-0.9-0.9
Social response proportion1.72.22.7-1.3-1.3-1.31.6-1.6-1.6
Social responses1.01.31.6-1.1-1.1-1.11.3-1.1-1.1
Social time2.13.34.32.11.81.8-1.61.81.8
Soleus weight0.51.33.3-0.7-1.2-1.31.8-0.8-0.7
Bone: stiffness0.81.41.9-0.9-1.3-1.31.4-1.0-1.0
Tibialis anterior weight3.913.315.9-3.5-3.8-3.84.0-3.4-3.4
Time to tail flick, vehicle, before self-admin1.41.73.1-1.8-1.2-1.10.5-1.4-1.5
Time to tail flick, vehicle, after self-admin0.30.62.6-0.1-0.6-0.71.6-0.1-0.1
Time to tail flick, test, before self-admin0.80.91.60.71.21.3-1.10.60.6
Time to tail flick, test, after self-admin0.40.40.80.40.60.6-0.40.90.9
Delta time to tail flick, vehicle, before/after SA0.10.10.40.3-0.1-0.10.70.10.1
Delta time to tail flick, test, before/after SA0.70.91.3-1.0-1.1-1.11.0-0.6-0.6
Tibia length0.20.61.3-0.6-0.6-0.60.4-1.1-1.1
Ambulatory time before self-admin0.00.00.00.1-0.1-0.10.0-0.2-0.2
Ambulatory time after self-admin0.40.61.00.70.80.8-1.00.80.7
Bone: tissue strength0.91.01.20.91.11.1-1.10.90.8
Total heroin consumption0.10.10.30.10.10.10.6-0.0-0.0
Bone: trabecular number0.00.00.00.00.10.10.10.10.1
Bone: trabecular spacing0.00.00.0-0.0-0.1-0.1-0.0-0.2-0.2
Bone: trabecular thickness1.52.12.2-1.5-1.4-1.41.4-1.5-1.5
Bone: trabecular tissue density0.40.70.9-0.7-0.8-0.80.8-1.0-1.0
Water consumed over 24 hours0.10.10.40.10.60.6-0.1-0.2-0.2
Number of responses in last shaping day2.43.14.8-1.8-1.8-1.82.2-1.4-1.4