Chst2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Chst2	0.19	0.07	5.0e-16	0.16	0.17	0.17	0.17	4.8e-15	4.3e-16	1.1e-15	3.0e-15
2	pVTA	mRNA stability	Chst2	0.19	0.09	7.5e-06	0.13	0.14	0.13	0.15	2.9e-06	1.4e-06	4.3e-06	5.2e-07
3	NAcc	mRNA stability	Chst2	0.15	0.07	4.6e-13	0.09	0.12	0.13	0.12	1.2e-10	6.5e-14	1.9e-14	2.6e-14
4	Brain	gene expression	Chst2	0.29	0.11	4.3e-14	0.17	0.17	0.15	0.16	2.7e-15	1.3e-15	3.2e-14	3.8e-15
5	NAcc	gene expression	Chst2	0.1	0.08	4.5e-03	0	-0	0	0	3.2e-01	4.3e-01	2.1e-01	1.4e-01
6	Adipose	gene expression	Chst2	0.07	0.04	8.0e-07	0.06	0.06	0.07	0.06	3.0e-07	9.0e-08	4.4e-08	2.3e-07
7	PL	gene expression	Chst2	0.25	0.16	9.6e-08	0.04	0.06	0.08	0.06	9.1e-05	4.0e-07	2.9e-09	2.8e-07
8	Liver	gene expression	Chst2	0.12	0.06	3.6e-11	0.09	0.09	0.09	0.09	1.1e-09	3.2e-10	2.4e-10	4.5e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	1.0	1.7	3.6	-1.7	-1.9	1.7	-1.1	-1.4	-0.6	0.4	-0.6
Area under the delay curve	0.5	0.5	1.1	-0.7	-0.4	0.7	-0.6	-0.7	-0.6	1.0	0.7
BMI with tail	3.8	12.2	25.9	3.4	3.8	-3.6	5.1	4.4	2.2	-2.3	-1.9
BMI without tail	2.8	5.8	13.0	3.6	3.6	-3.1	2.1	2.1	-0.8	0.9	0.9
Body weight	3.0	12.7	29.1	2.2	3.0	-2.7	5.4	4.3	2.8	-3.6	-3.6
Weight adjusted by age	1.0	1.1	2.7	-1.0	-0.5	1.0	0.7	0.0	1.2	-1.6	-1.5
Bone surface	0.9	1.6	3.3	-1.8	-1.8	1.6	-0.9	-1.3	-0.8	0.5	-0.4
Bone volume	0.6	0.9	1.8	-1.3	-1.3	1.2	-0.8	-1.1	-0.6	0.5	-0.3
Breakpoint value in progressive ratio session	1.0	1.1	2.1	-1.3	-1.1	1.4	-1.2	-1.5	0.1	0.7	0.1
Number of licking bursts	0.2	0.2	0.4	-0.5	-0.7	0.5	-0.5	-0.5	0.0	-0.1	-0.3
Context. condit. distance diff. score	0.2	0.2	0.7	0.0	-0.1	-0.3	0.8	0.5	0.3	-0.1	-0.8
Locomotion velocity, session 1	3.7	4.0	9.9	2.7	3.1	-2.6	2.0	2.1	0.2	-0.3	-0.0
Locomotion distance, session 1	5.3	6.8	14.0	3.3	3.7	-3.3	2.9	3.1	0.8	-0.5	-0.2
Locomotion velocity, session 2	6.8	7.9	13.8	3.6	3.7	-3.7	3.0	3.4	1.5	-1.1	0.0
Locomotion distance, session 2	6.4	9.0	16.8	4.0	4.1	-4.0	3.1	3.6	0.9	-0.3	0.0
Locomotion velocity, session 3	1.4	1.6	3.3	1.8	1.5	-1.7	0.0	0.8	-0.5	1.6	1.1
Locomotion distance, session 3	0.0	0.0	0.1	0.1	0.2	-0.1	0.2	0.2	0.1	0.1	-0.3
Stereotopy head waving bouts, day 3	0.9	1.1	3.1	-1.4	-1.8	1.1	-0.3	-0.3	-1.0	0.4	-1.2
Stereotopy head waving duration, day 3	0.2	0.2	0.7	0.0	-0.3	-0.2	0.1	0.4	-0.8	0.3	-0.8
Locomotion velocity, session 7	2.6	2.9	6.3	2.5	2.2	-2.4	1.5	1.6	-0.1	0.8	0.8
Locomotion distance, session 7	0.2	0.3	0.7	0.8	0.7	-0.7	0.5	0.3	0.0	0.1	0.5
Stereotopy head waving bouts, day 7	0.7	0.8	2.6	-0.2	-0.2	0.3	-1.2	-0.7	-1.1	1.6	0.0
Stereotopy head waving duration, day 7	1.1	1.3	4.2	-0.2	-0.2	0.3	-1.5	-0.9	-1.6	2.0	0.7
Locomotion velocity, session 8	4.4	5.3	12.1	3.5	3.4	-3.3	1.5	2.3	0.5	0.7	0.3
Locomotion distance, session 8	2.8	4.1	7.4	2.6	2.7	-2.7	2.2	2.3	0.8	0.0	-0.5
Degree of sensitization distance	0.1	0.1	0.3	0.4	0.2	-0.3	0.2	0.1	-0.1	0.0	0.6
Degree of sensitization stereotypy	0.2	0.2	0.7	0.3	0.6	-0.3	-0.3	0.0	-0.0	0.9	-0.0
Conditioned locomotion	1.5	1.8	6.3	1.2	1.2	-0.5	-1.5	-0.7	-0.6	1.3	2.5
Cocaine response after cond. corrected	0.8	0.9	1.8	1.2	1.2	-1.0	0.2	0.4	-0.5	0.9	1.3
Cocaine response after cond. not corrected	0.8	0.8	1.5	1.2	1.0	-1.0	0.6	0.6	-0.6	0.9	1.2
Cocaine response before conditioning	0.1	0.1	0.3	0.2	-0.2	-0.2	0.4	0.2	-0.6	0.4	0.1
Saline control response	1.2	1.5	2.8	1.4	1.0	-1.4	1.7	1.5	1.5	-0.6	0.2
Bone: connectivity density	0.8	1.3	2.3	-1.2	-1.2	1.2	-1.5	-1.5	-0.8	0.8	0.2
Bone: cortical apparent density	0.4	0.6	1.3	1.1	1.1	-0.6	-0.6	-0.1	1.1	-0.4	0.4
Bone: cortical area	1.2	1.9	3.7	0.9	1.0	-1.2	1.7	1.9	1.8	-1.0	-1.1
Bone: cortical porosity	0.3	0.3	0.7	0.2	0.2	-0.4	0.8	0.8	0.8	-0.4	-0.1
Bone: cortical porosity	0.4	0.4	1.1	0.4	0.3	-0.7	0.7	0.9	1.0	-0.3	0.1
Bone: cortical thickness	0.5	0.8	2.7	0.8	0.5	-0.9	0.7	1.2	1.6	-0.2	-0.1
Bone: cortical thickness	0.4	0.4	0.7	-0.8	-0.8	0.8	-0.2	-0.5	0.5	-0.5	-0.8
Bone: cortical tissue density	0.5	0.6	1.5	1.1	1.2	-0.7	-0.6	-0.0	1.1	-0.4	0.4
Condit. Reinf. active minus inactive responses	1.1	1.3	4.0	-1.5	-1.2	1.4	-0.1	-0.4	0.4	-0.6	-2.0
Condit. Reinf. active-inactive response ratio	1.4	1.5	5.0	-0.5	-0.5	0.3	1.6	1.2	1.2	-1.0	-2.2
Condit. Reinf. active responses	0.5	0.6	1.1	-0.8	-0.8	0.9	-0.9	-0.7	-0.5	0.5	-1.0
Condit. Reinf. inactive responses	1.3	1.6	4.3	-0.2	-0.4	0.5	-2.1	-1.6	-1.6	1.4	0.9
Incentive salience index mean	0.9	1.1	4.7	-1.0	-0.7	0.7	0.3	0.4	0.9	-0.9	-2.2
Condit. Reinf. lever presses	1.3	1.8	3.6	1.2	1.4	-1.5	1.4	1.9	1.1	-0.9	-1.0
Condit. Reinf. active minus inactive responses	1.0	1.3	2.1	-1.4	-1.2	1.5	-0.8	-1.3	-1.2	0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.3	0.1	0.5	-0.0	-0.5	-0.7	0.0	-0.7
Condit. Reinf. active responses	1.4	2.0	2.8	-1.5	-1.6	1.5	-1.3	-1.7	-1.6	1.3	0.0
Condit. Reinf. inactive responses	1.0	1.2	2.1	-0.8	-1.3	0.7	-1.0	-1.0	-1.4	1.5	0.8
Condit. Reinf. lever presses	1.3	1.8	5.7	-2.1	-2.4	1.7	-0.3	-0.8	-0.5	0.1	-0.7
Condit. Reinf. lever reinforcers received	1.5	2.1	3.4	-1.8	-1.8	1.7	-1.1	-1.6	-1.5	1.1	-0.3
Conditioned reinforcement - actives	0.1	0.1	0.2	0.0	0.1	-0.2	0.4	0.1	-0.4	0.1	-0.4
Conditioned reinforcement - inactives	0.6	0.7	1.5	1.1	1.2	-1.2	0.7	0.6	-0.4	0.3	0.8
Conditioned locomotion	0.1	0.1	0.3	0.1	0.3	-0.1	0.1	0.2	0.5	-0.3	-0.5
Patch foraging indifference point 0 sec	0.4	0.6	1.2	0.9	0.8	-0.8	0.7	0.8	0.6	-0.1	1.1
Patch foraging indifference point AUC	0.6	0.7	1.6	1.3	1.1	-1.1	-0.3	0.4	0.5	0.1	1.0
Delay disc. indifference point, 0s delay	1.8	2.0	3.3	-1.2	-1.2	1.3	-1.8	-1.6	-1.0	1.7	1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.5	-0.4	0.3	0.2	0.0	0.1	0.3	-0.6
Delay disc. indifference point, 2s delay	0.3	0.3	0.9	-0.0	-0.1	-0.2	0.6	0.5	-0.7	0.9	0.8
Delay disc. indifference point, 24s delay	0.2	0.2	0.3	-0.5	-0.5	0.6	-0.4	-0.6	0.3	-0.1	-0.4
Delay disc. indifference point, 4s delay	2.1	2.2	5.2	0.6	0.8	-0.0	-1.1	-0.8	-2.1	2.2	2.3
Delay disc. indifference point, 8s delay	0.7	0.7	2.2	-1.5	-1.0	1.3	-0.3	-0.7	0.4	-0.2	-0.3
Indifference point function ln k	0.8	1.1	2.7	-1.7	-1.6	1.4	0.3	-0.5	-0.4	-0.5	-1.0
Indifference point function log k	0.8	1.1	2.7	-1.7	-1.6	1.4	0.3	-0.5	-0.4	-0.5	-1.0
Patch foraging total patch changes 0 sec	0.4	0.7	1.1	0.9	0.8	-0.9	1.0	1.0	0.7	-0.4	0.8
Patch foraging total patch changes 12 sec	0.9	1.1	2.2	1.4	1.5	-1.3	0.5	0.9	1.2	-0.3	0.7
Patch foraging total patch changes 18 sec	0.5	0.7	0.9	0.8	0.9	-0.9	0.9	0.9	0.7	-0.9	0.4
Patch foraging total patch changes 24 sec	0.1	0.1	0.7	-0.0	0.1	-0.2	0.2	0.1	0.0	-0.8	0.3
Patch foraging total patch changes 6 sec	0.5	0.7	2.3	1.1	0.8	-0.7	-0.5	0.2	0.1	0.9	1.5
Patch foraging time to switch 0 sec	0.6	0.9	2.9	0.0	0.2	0.4	-1.7	-1.3	-0.8	0.9	1.1
Patch foraging water rate 0 sec	0.2	0.4	1.4	-0.1	-0.1	-0.1	1.2	0.7	-0.2	-0.3	-0.9
Patch foraging water rate 12 sec	0.3	0.5	2.2	-0.0	0.2	-0.4	1.5	0.9	-0.1	-0.6	-0.7
Patch foraging water rate 18 sec	1.1	1.5	4.8	0.7	0.4	-1.1	2.2	1.8	0.3	-0.7	-1.3
Patch foraging water rate 24 sec	0.2	0.2	0.6	-0.6	-0.8	0.6	0.2	-0.1	-0.1	0.0	-0.8
Patch foraging water rate 6 sec	0.4	0.6	2.3	-0.5	-0.7	-0.0	1.5	0.9	-0.2	-0.3	-1.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	1.0	0.7	1.0	-0.4	-0.5	-0.2	0.3	0.0	-0.0
Distance traveled before self-admin	1.8	2.0	2.9	1.5	1.6	-1.7	1.7	1.7	1.2	-1.1	0.1
Distance traveled after self-admin	1.2	1.3	6.2	-0.2	0.5	0.4	0.3	0.1	1.6	-2.5	-1.0
Extensor digitorum longus weight	2.2	8.7	15.9	3.0	2.9	-3.4	3.8	4.0	2.3	-1.5	-1.5
Bone: elastic displacement	1.2	1.4	3.9	0.5	0.2	-0.8	1.6	1.4	2.0	-1.4	-0.3
Bone: elastic work	0.3	0.4	1.4	-0.4	-0.4	0.2	0.8	0.5	1.2	-0.9	-0.3
Bone: endosteal estimation	0.3	0.7	1.5	0.8	1.1	-1.0	1.2	1.1	-0.2	-0.0	-0.0
Bone: endosteal perimeter	1.3	2.7	6.2	1.1	1.4	-1.6	2.5	2.4	1.5	-1.1	-0.9
Epididymis fat weight	0.6	1.4	3.5	1.6	1.9	-1.4	1.1	1.2	0.5	-0.3	-0.8
Delta time in closed arm before/after self-admin	0.5	0.5	1.9	-0.0	0.1	0.3	-1.2	-0.3	1.4	-0.2	0.3
Delta time in open arm before/after self-admin	1.9	1.8	5.0	1.9	2.2	-1.7	0.4	0.6	-0.5	0.7	1.4
Diff in mean of infusions in LGA sessions	0.6	0.7	1.7	-1.3	-1.0	0.8	0.1	-0.4	-1.1	0.5	-0.7
Delay discount exponential model param	0.4	0.5	1.2	0.4	0.2	-0.5	0.5	0.6	0.7	-1.1	-0.9
Extinction: sum of active levers before priming	0.7	0.7	1.9	-0.7	-0.5	0.8	-0.2	-0.3	1.4	-0.6	-1.2
Active lever presses in extinction session 6	0.9	0.9	2.7	0.6	0.9	-0.7	0.5	0.8	1.7	-1.4	-0.1
Bone: final force	0.1	0.1	0.2	-0.5	-0.2	0.5	-0.2	-0.5	-0.2	0.1	-0.4
Bone: final moment	0.1	0.2	0.4	-0.7	-0.4	0.6	-0.1	-0.5	-0.2	-0.0	-0.5
Food consumed during 24 hour testing period	0.6	0.7	1.0	-1.0	-1.0	0.9	-0.6	-0.8	-0.9	0.4	-1.0
Glucose	0.4	0.6	1.5	1.2	1.2	-1.1	0.4	0.7	0.3	0.1	0.3
Heart weight	2.0	2.9	6.3	-1.4	-1.2	1.0	1.5	0.6	2.0	-2.4	-2.5
Delay discount hyperbolic model param	0.5	0.5	1.5	0.3	0.1	-0.4	0.4	0.5	0.9	-1.2	-1.0
Intermittent access intake day 1-15 change	0.7	0.7	1.6	0.4	0.6	-0.7	1.3	0.8	0.1	-1.0	-1.3
Intermittent access intake escalation	0.6	0.5	1.2	0.5	0.7	-0.6	1.1	0.7	-0.0	-0.7	-1.1
Intermittent access intake escalation 2	0.2	0.2	0.8	-0.0	0.1	-0.3	0.6	0.3	-0.1	-0.7	-0.9
Intermitt. access day 1 inactive lever presses	1.6	1.7	2.6	1.6	1.4	-1.6	0.6	1.5	1.5	-0.7	1.0
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.6	0.0	0.0	-0.3	0.2	0.4	0.8	0.1	-0.3
Intermitt. access escalation Index	1.1	1.0	3.3	0.5	-0.0	-0.7	0.1	0.3	-1.8	1.8	0.7
Intermittent access day 1 total infusions	0.3	0.3	0.6	0.7	0.8	-0.6	0.7	0.6	0.1	0.2	-0.5
Intermittent access day 15 total infusions	0.6	0.7	1.3	0.9	1.0	-1.0	1.1	0.7	-0.7	0.6	-0.6
Intermittent access terminal intake (last 3 days)	0.7	0.8	2.9	0.4	0.6	-0.8	1.7	1.0	-0.1	-0.1	-1.0
Intermittent access total infusions	0.6	0.7	1.4	1.0	1.2	-1.1	1.0	0.8	-0.0	0.4	-0.4
Intermittent access day 1 locomotion	0.3	0.3	0.7	0.8	0.7	-0.5	0.2	0.6	0.9	0.3	0.3
Intermittent access day 15 total locomotion	0.4	0.4	1.1	0.8	1.1	-0.6	0.5	0.6	0.4	-0.2	-0.3
Intermittent access total locomotion	0.7	0.8	1.3	1.2	1.1	-1.0	0.5	0.9	1.1	-0.3	-0.1
Intermittent access standard deviation	0.1	0.2	0.8	-0.4	0.1	0.2	-0.3	-0.2	0.1	0.3	-0.9
Left kidney weight	3.0	8.3	13.8	2.8	3.2	-2.9	3.5	3.7	2.7	-1.9	-1.9
Right kidney weight	3.6	10.0	16.5	3.1	3.3	-3.2	3.9	4.1	3.0	-2.1	-2.1
Cocaine induced anxiety	0.9	1.0	3.3	-1.5	-1.8	1.1	-0.7	-0.5	0.4	-0.2	-0.4
Post-drug Anxiety	1.0	1.1	3.9	-1.5	-2.0	1.2	-0.6	-0.6	0.0	0.2	-0.2
Baseline Anxiety	0.0	0.0	0.2	-0.1	-0.1	0.1	0.4	0.1	0.1	-0.2	-0.0
Tail length	0.1	0.5	1.6	0.6	0.6	-0.2	-0.3	-0.4	-1.3	0.8	0.7
Length with tail	0.4	1.5	5.2	-0.9	-0.3	0.5	1.2	0.6	0.9	-1.7	-2.3
Length without tail	3.5	7.7	18.0	-1.9	-1.1	0.8	3.0	1.8	3.0	-4.1	-4.2
Times rat made contact with spout	1.0	1.1	2.4	-0.5	-0.6	-0.1	1.1	1.0	1.3	-1.4	-1.5
Lifetime Intake	0.5	0.5	1.1	0.8	0.8	-0.9	1.0	0.7	-0.0	0.4	-0.6
Liver weight, left	0.4	0.7	1.5	1.2	1.0	-1.2	0.4	1.0	0.0	0.5	0.2
Liver weight, right	2.2	3.7	7.3	2.7	2.6	-2.6	1.8	2.0	0.4	0.7	0.7
Locomotor activity	0.3	0.5	1.7	0.4	-0.1	-0.6	1.3	1.1	0.2	-0.8	0.1
Locomotor testing distance	0.2	0.4	1.1	0.5	0.1	-0.7	1.1	0.9	-0.4	-0.3	0.2
Locomotor testing rearing	1.1	1.7	3.0	1.7	1.5	-1.7	1.3	1.3	-0.8	0.8	0.8
Locomotion in novel chamber	1.4	1.7	3.6	-1.0	-1.5	1.1	-1.9	-1.5	-0.7	1.6	0.6
Locomotion in novel chamber post-restriction	0.9	1.1	2.9	-1.0	-1.7	0.8	-0.5	-0.5	-1.4	1.3	0.2
Fecal boli incidents, locomotor time 1	1.1	1.2	2.4	1.4	0.8	-1.5	1.1	1.5	-0.6	0.5	0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	1.1	0.6	1.0	-0.4	0.7	-0.1	-0.1	-0.4	-0.2
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	0.3	0.5	-0.3	0.6	0.1	0.9	-0.5	-0.7
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.3	-0.6	0.2	-0.1	-0.0	-0.1	-0.0	-0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	0.1	-0.4	-0.3	0.3	0.5	0.1	-0.1	-0.2
Rest time, locomotor task time 1	1.6	1.7	3.3	0.3	0.2	-0.9	1.8	1.5	1.6	-1.6	-1.5
Distance moved, locomotor task time 1	1.3	1.4	4.0	0.7	0.8	-0.3	-1.1	-0.5	-1.2	1.8	2.0
Vertical activity count, locomotor time 1	0.7	0.7	2.1	-0.6	-0.4	0.8	-1.4	-0.9	-0.1	1.2	0.5
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.8	-0.6	-0.6	0.2	0.3	0.1	0.5	0.1	-0.9
Bouts of movement, locomotor time 2	0.2	0.2	0.5	0.3	0.2	-0.4	0.1	0.5	0.6	-0.7	-0.5
Total resting periods, locomotor time 2	0.3	0.3	1.1	0.0	0.0	-0.2	0.1	0.4	1.0	-1.0	-0.7
Rest time, locomotor task time 2	0.2	0.2	0.8	0.1	0.1	-0.1	0.4	-0.1	0.9	-0.8	-0.2
Distance moved, locomotor task time 2	0.9	1.0	2.2	-0.1	0.1	0.2	-1.2	-0.6	-1.4	1.5	1.4
Vertical activity count, locomotor time 2	0.7	0.7	1.5	-1.1	-1.0	1.1	-1.2	-0.6	-0.3	0.8	-0.1
Light reinforcement 1	0.1	0.1	0.5	-0.0	0.1	-0.1	0.3	0.1	-0.7	0.6	0.4
Light reinforcement 2	0.2	0.3	0.8	-0.9	0.1	0.7	0.2	-0.4	0.2	-0.4	-0.8
Bone: marrow area	0.4	0.8	1.7	0.8	1.1	-1.1	1.3	1.2	-0.1	-0.1	-0.1
Bone: maximum diameter	3.0	5.5	11.7	2.3	2.4	-2.8	3.1	3.4	1.7	-0.7	-0.9
Bone: maximum force	0.1	0.1	0.5	-0.1	0.0	0.0	0.3	0.2	0.7	-0.3	-0.2
Bone: maximum moment	0.1	0.2	0.6	-0.2	-0.1	0.1	0.5	0.3	0.8	-0.5	-0.4
Mean time between licks in bursts	1.2	1.7	4.2	-1.0	-0.9	0.7	0.6	0.5	1.6	-2.0	-2.0
Mean num. licks in bursts	0.8	0.9	1.9	0.0	0.2	-0.4	1.4	1.2	1.2	-1.1	-0.9
Cd content in liver	0.1	0.2	0.4	-0.7	-0.3	0.3	0.3	0.2	0.2	-0.2	-0.6
Co content in liver	0.2	0.3	0.4	0.3	0.6	-0.5	0.6	0.6	0.7	-0.3	-0.5
Cu content in liver	2.0	2.4	5.6	-2.3	-2.4	2.1	-1.1	-1.4	-0.1	1.0	-0.1
Fe content in liver	1.7	2.1	5.7	-2.4	-2.3	2.0	-0.2	-1.0	-0.4	-0.0	-0.7
K content in liver	4.0	3.9	7.2	2.7	2.0	-2.3	-0.2	0.8	-1.3	2.6	2.5
Mg content in liver	1.9	2.0	3.8	1.9	1.5	-1.7	-0.3	0.5	-0.5	1.6	1.9
Mn content in liver	2.0	2.2	4.4	2.0	2.0	-2.1	1.1	1.5	-0.5	1.3	-0.1
Na content in liver	1.8	1.9	5.6	1.0	0.6	-0.4	-1.1	-0.7	-1.3	2.4	2.2
Rb content in liver	0.2	0.3	1.6	-0.0	-0.5	-0.1	-0.0	-0.0	-0.7	0.3	1.3
Se content in liver	1.5	1.8	3.9	-0.9	-0.8	0.9	-1.4	-1.4	-2.0	1.8	0.9
Sr content in liver	0.4	0.4	1.7	0.0	0.1	0.1	-0.6	-0.5	-1.3	0.9	0.2
Zn content in liver	0.5	0.5	1.3	0.7	0.6	-0.6	0.1	0.2	-0.6	1.1	1.2
Bone: minimum diameter	0.3	0.5	1.4	-0.9	-0.4	0.6	0.5	0.3	0.6	-0.8	-1.2
Time in familiar zone, hab. session 1	2.7	2.6	5.3	-1.6	-1.1	2.0	-1.9	-2.3	-1.9	0.5	0.3
Time in novel zone, hab. session 1	1.8	1.8	3.7	0.8	0.3	-1.1	1.9	1.9	1.9	-1.1	-0.5
Total zone transitions, hab. session 1	3.9	5.5	11.6	3.4	3.2	-3.2	1.8	2.4	0.2	1.0	1.2
Total locomotion distance, hab. session 1	2.2	3.2	6.8	2.6	2.4	-2.3	1.3	1.7	0.1	0.7	1.5
Locomotion velocity, hab. session 1	3.3	4.7	10.7	3.3	3.1	-2.8	1.3	1.8	0.0	1.1	1.8
Time in familiar zone, hab. session 2	0.7	0.7	1.4	-1.2	-1.1	1.2	-0.4	-0.9	-1.0	0.4	0.0
Time in novel zone, hab. session 2	1.7	1.7	3.2	1.0	0.9	-1.2	1.4	1.5	1.8	-1.3	-1.1
Total zone transitions, hab. session 2	3.5	4.6	10.0	3.0	3.2	-2.8	2.0	2.4	0.3	0.3	0.1
Total locomotion distance, hab. session 2	2.3	3.1	7.3	2.5	2.7	-2.3	1.5	1.6	-0.2	0.4	0.8
Locomotion velocity, hab. session 2	2.6	3.5	8.5	2.7	2.9	-2.5	1.4	1.6	-0.3	0.6	1.1
Novel to familiar place preference ratio	0.3	0.3	1.0	-0.3	-0.6	0.2	0.4	0.3	0.7	-1.0	-0.8
Novelty place preference	0.7	0.7	1.9	-0.5	-0.7	0.3	0.6	0.4	0.9	-1.4	-1.2
Time in novel zone, NPP test	1.1	1.2	2.9	-0.6	-0.9	0.3	1.0	0.7	1.2	-1.7	-1.5
Total zone transitions, NPP test	7.3	10.4	17.5	3.8	3.8	-4.1	4.0	4.2	1.6	-1.1	-0.4
Total locomotion distance, NPP test	4.3	5.8	11.2	3.3	3.1	-3.3	2.5	2.8	0.2	0.3	0.7
Locomotion velocity, NPP test	3.7	5.3	11.0	3.3	3.2	-3.2	2.0	2.3	-0.0	0.7	1.1
Intraocular pressure	0.6	0.9	1.8	1.0	0.9	-1.2	1.3	1.3	0.1	-0.5	-0.1
Delta distance traveled before/after self-admin	1.0	1.1	1.7	-1.0	-0.6	1.3	-1.3	-1.1	0.8	-1.3	-0.4
Delta ambulatory time before/after self-admin	0.5	0.6	1.3	-0.5	-0.2	0.8	-1.1	-0.9	0.6	-1.1	-0.2
Parametrial fat weight	0.1	0.2	0.5	0.3	0.5	-0.2	-0.5	-0.3	-0.7	0.5	-0.1
Pavlov. Cond. lever latency	0.6	0.8	1.4	-0.2	-0.3	0.7	-1.0	-1.2	-1.1	1.2	0.7
Pavlov. Cond. magazine entry latency	0.8	1.0	2.0	-0.4	0.4	-0.2	1.1	1.0	1.4	-1.3	-1.4
Pavlov. Cond. change in total contacts	0.3	0.3	0.7	-0.1	0.4	-0.2	0.8	0.6	0.6	-0.6	-0.8
Pavlov. Cond. index score	0.8	1.0	2.2	-0.3	0.1	-0.2	1.1	1.0	1.5	-1.5	-1.2
Pavlov. Cond. latency score	0.9	1.2	2.6	-0.1	0.3	-0.4	1.3	1.2	1.5	-1.6	-1.1
Pavlov. Cond. lever contacts	0.6	0.7	1.5	0.0	0.0	-0.5	1.0	1.1	1.2	-1.2	-0.6
Pavlov. Cond. magazine entry number	0.9	1.1	2.8	0.9	0.1	-0.4	-0.7	-0.4	-1.4	1.7	1.6
Pavlov. Cond. intertrial magazine entries	2.9	3.6	6.0	-2.1	-2.5	2.2	-2.0	-2.3	-1.6	1.0	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.9	-0.3	0.2	-0.2	1.0	0.9	1.4	-1.4	-1.2
Pavlov. Cond. response bias	0.4	0.5	1.2	-0.9	-0.5	0.4	0.3	0.3	0.9	-0.9	-1.1
Pavlov. Cond. lever latency	0.3	0.4	1.2	1.0	1.1	-0.7	-0.5	0.1	0.0	0.3	0.4
Pavlov. Cond. magazine entry latency	1.2	1.4	3.2	-0.4	-0.3	-0.0	1.3	1.1	1.8	-1.7	-1.4
Pavlov. Cond. change in total contacts	0.3	0.4	1.6	-0.1	-0.2	-0.2	1.3	0.7	0.2	-0.4	-0.8
Pavlov. Cond. index score	0.7	0.9	1.6	-1.3	-1.3	0.9	0.7	0.1	0.7	-1.1	-1.0
Pavlov. Cond. latency score	0.7	0.8	1.3	-1.1	-1.1	0.7	0.8	0.3	0.9	-1.1	-1.0
Pavlov. Cond. lever contacts	0.4	0.6	1.2	-1.1	-1.1	0.7	0.8	0.2	0.4	-0.7	-0.7
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	0.6	0.6	-0.3	-0.6	-0.5	-1.1	0.8	1.0
Pavlov. Cond. intertrial magazine entries	2.7	3.6	8.1	-1.3	-1.1	1.7	-2.8	-2.6	-1.8	1.6	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.4	-1.1	-1.1	0.8	0.8	0.3	0.9	-1.2	-1.2
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.9	-0.9	0.6	0.7	0.2	0.3	-0.5	-0.8
Time in closed arm before self-admin	0.4	0.4	2.1	0.4	-0.2	-0.5	0.9	0.4	-1.4	-0.0	-0.3
Time in closed arm after self-admin	0.3	0.3	0.7	0.5	0.2	-0.6	0.5	0.8	0.3	-0.8	-0.1
Time in open arm before self-admin	1.9	2.0	4.1	-1.8	-1.5	2.0	-1.8	-1.7	0.7	0.2	-0.2
Time in open arm after self-admin	0.7	0.7	1.7	0.0	0.8	0.4	-1.3	-0.9	0.0	1.2	1.0
Bone: periosteal estimation	0.8	1.6	3.2	1.1	1.4	-1.5	1.7	1.8	0.8	-0.3	-0.4
Bone: periosteal perimeter	1.6	2.6	5.4	1.1	1.4	-1.6	2.3	2.3	1.6	-1.0	-1.1
Bone: post-yield work	0.1	0.2	0.4	-0.5	-0.6	0.3	0.1	0.1	0.3	-0.3	-0.6
Progressive ratio test 1 active lever presses	0.4	0.5	0.9	0.8	1.0	-0.9	0.6	0.8	0.3	0.0	-0.3
Progressive ratio test 1 breakpoint	0.7	0.7	1.3	1.0	1.1	-1.1	0.9	1.1	0.6	-0.1	-0.3
Progressive ratio test 1 inactive lever presses	0.2	0.3	1.4	0.4	0.3	-0.3	0.1	0.3	1.2	-0.4	-0.1
Progressive ratio test 2 active lever presses	0.2	0.3	1.4	-0.2	-0.0	-0.0	0.8	-0.0	-0.1	-0.2	-1.2
Progressive ratio test 2 breakpoint	0.2	0.2	1.3	-0.2	0.1	0.0	0.5	-0.2	-0.1	-0.2	-1.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.5	-0.5	0.3	-0.0	-0.0
Incentive Sensitization - Responses	0.7	0.7	2.7	-0.6	-0.1	0.4	0.3	-0.6	-1.1	0.7	-1.6
Incentive Sensitization - Breakpoint	0.7	0.7	3.1	-0.7	-0.2	0.4	0.4	-0.6	-1.1	0.6	-1.8
Sum of active levers in priming session hrs 5-6	0.7	0.7	2.5	-0.3	0.4	0.1	0.9	0.6	1.2	-0.7	-1.6
Progressive ratio	0.7	0.8	2.8	0.6	0.2	-0.8	1.2	1.7	0.9	-0.5	-0.3
Food seeking constrained by brief footshock	0.5	0.6	1.4	0.9	0.8	-0.9	0.7	0.8	0.4	1.2	0.2
Seeking ratio, punishment vs. effort	0.3	0.4	1.5	0.0	0.3	0.1	-0.5	-0.7	-0.8	1.2	0.4
Retroperitoneal fat weight	0.3	1.1	2.8	1.3	1.7	-0.9	1.0	0.8	0.7	-0.4	-1.0
Reaction time number correct	0.1	0.2	0.6	0.5	0.5	-0.4	0.0	-0.0	-0.8	0.3	-0.0
Reaction time mean minus median	1.6	2.1	3.8	1.6	1.4	-1.8	1.6	1.9	1.4	-0.9	0.3
Reaction time mean minus median AUC	2.1	2.7	5.4	2.1	1.8	-2.3	1.7	2.1	1.0	-0.5	0.5
Reaction time num false alarms	0.4	0.5	1.5	-0.9	-1.2	0.8	-0.3	-0.5	-0.9	0.3	0.2
Reaction time num false alarms AUC	0.3	0.4	0.9	-0.7	-0.9	0.5	-0.5	-0.5	-0.7	0.4	0.5
Reaction time trials correct on left	0.1	0.2	0.6	0.5	0.5	-0.4	0.0	-0.0	-0.8	0.3	-0.0
Reaction time trials on left	0.1	0.2	0.6	0.5	0.5	-0.4	0.1	0.0	-0.8	0.3	0.0
Reaction time mean	0.7	1.0	2.2	1.0	1.0	-1.1	0.8	1.2	1.5	-0.8	0.2
Reaction time mean AUC	0.4	0.5	1.0	0.8	0.8	-0.9	0.3	0.7	1.0	-0.4	0.4
Median of all reaction times	0.2	0.2	0.9	0.4	0.5	-0.4	-0.0	0.4	1.0	-0.4	0.3
Reaction time omissions	0.2	0.2	0.7	0.7	0.6	-0.6	0.0	0.2	0.1	-0.0	0.8
Reaction time false alarm rate	0.3	0.4	1.2	-0.8	-1.1	0.7	-0.3	-0.4	-0.5	0.3	0.4
Reaction time premature initiation rate	0.3	0.5	1.8	-0.3	-0.2	0.3	-0.3	-0.4	-1.3	1.2	0.2
Reaction time premature initiations	0.3	0.5	2.2	0.1	0.3	-0.0	-0.2	-0.2	-1.5	1.2	0.2
Std. dev. reaction times	1.1	1.5	2.5	1.5	1.3	-1.6	1.2	1.5	1.2	-0.7	0.6
Reaction time trials completed	0.1	0.2	0.6	0.5	0.5	-0.4	0.1	0.0	-0.8	0.3	0.0
Reaction time trials AUC	0.1	0.1	0.6	0.3	0.3	-0.3	-0.0	-0.1	-0.8	0.3	0.0
Run reversals in cocaine runway, females	0.3	0.3	0.6	0.3	0.5	0.1	-0.6	-0.7	-0.6	0.3	0.8
Run reversals in cocaine runway, males	1.3	1.2	2.7	-0.5	-0.3	-0.2	1.3	1.0	1.5	-1.6	-1.3
Latency to leave start box in cocaine runway	2.4	2.6	7.3	-1.6	-1.6	1.8	-2.7	-2.1	-0.2	0.6	-0.2
Latency to leave start box in cocaine runway, F	1.0	1.1	3.7	-0.7	-0.7	1.0	-1.9	-1.7	-0.6	0.1	0.2
Latency to leave start box in cocaine runway, M	2.0	1.9	4.7	-1.4	-1.6	1.5	-2.2	-1.5	-0.2	1.3	-0.5
Std. dev. time between licks in bursts	0.2	0.2	0.5	0.0	-0.4	-0.0	-0.7	-0.2	-0.5	0.6	0.5
Total sessions with >9 infusions	0.5	0.5	1.4	0.7	0.9	-0.7	1.2	0.7	0.1	-0.5	-0.7
Short access day 1 total inactive lever presses	1.9	2.2	5.0	2.2	2.0	-1.7	-0.5	0.5	0.4	0.9	1.9
Short access day 10 total inactive lever presses	1.7	1.9	3.4	1.7	1.8	-1.8	0.9	1.4	1.4	-0.4	0.5
Short access day 1 total infusions	1.0	1.0	2.4	1.5	1.1	-1.5	0.7	1.0	-0.4	0.9	0.2
Short access day 10 total infusions	0.6	0.6	1.4	0.7	0.8	-0.8	1.2	0.9	0.6	0.1	-0.8
Short access total infusions	1.0	1.1	2.3	1.5	1.3	-1.5	1.1	1.0	0.0	0.7	0.1
Short access day 1 locomotion	2.2	2.4	5.6	2.2	1.4	-1.7	-0.3	0.4	-0.9	1.6	2.4
Short access day 10 total locomotion	2.1	2.3	7.6	1.7	1.4	-1.5	0.7	1.6	2.8	-1.0	-0.2
Short access total locomotion	1.6	1.6	3.2	1.8	1.6	-1.5	0.9	1.3	1.4	-0.1	0.8
One hour access (0.3 mA shock)	0.2	0.2	1.0	-0.4	-0.1	0.3	-0.2	-0.5	-1.0	0.1	0.1
Compulsive drug intake	3.2	3.2	7.1	-1.1	-1.5	1.5	-2.7	-2.2	-1.9	1.3	1.8
One hour access (shock baseline)	0.4	0.4	1.9	-0.6	-0.2	0.3	0.9	0.1	-0.0	-0.2	-1.4
Social response proportion	0.4	0.4	1.5	-0.5	-0.4	0.4	-0.0	0.1	1.2	-0.9	-0.8
Social responses	0.1	0.1	0.5	0.0	0.1	-0.1	-0.0	0.0	0.2	0.2	-0.7
Social time	0.5	0.7	1.7	-0.2	-0.3	-0.2	0.6	1.0	1.0	-1.3	-1.2
Soleus weight	0.9	2.5	4.4	2.0	1.9	-2.1	1.8	2.0	0.5	-0.3	-0.6
Bone: stiffness	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.1	-0.1	0.2	0.1	-0.4
Tibialis anterior weight	1.0	3.5	7.6	1.3	1.6	-1.6	2.8	2.3	1.4	-2.1	-1.5
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.8	0.7	0.3	-0.8	-0.1	0.5	-1.1	1.3	0.9
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.5	0.7	0.7	-0.6	0.7	0.5	0.6	-0.3	0.2
Time to tail flick, test, before self-admin	0.6	0.6	1.5	-0.6	-0.9	0.6	-0.7	-0.7	-1.2	0.9	0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.7	-0.6	-0.1	0.6	0.0	0.1	0.3	-0.8	-0.3
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.8	0.6	0.8	-0.4	0.8	0.4	1.3	-1.0	-0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	0.9	0.1	0.5	-0.0	0.3	0.4	0.3	-0.9	-0.1
Tibia length	0.2	0.7	1.7	0.1	0.4	-0.3	1.2	0.9	0.7	-1.3	-0.8
Ambulatory time before self-admin	1.5	1.6	3.3	1.3	1.3	-1.5	1.8	1.6	0.8	-0.8	0.1
Ambulatory time after self-admin	1.0	1.1	5.2	0.1	0.7	0.0	0.3	0.3	1.7	-2.3	-0.4
Bone: tissue strength	0.0	0.0	0.1	-0.2	-0.2	0.2	0.1	-0.1	0.0	-0.0	0.3
Total heroin consumption	2.3	2.7	6.5	-2.6	-2.2	2.1	0.1	-0.8	0.6	-0.5	-2.1
Bone: trabecular number	1.4	2.2	3.7	-1.9	-1.9	1.8	-1.7	-1.7	-0.6	0.5	-0.8
Bone: trabecular spacing	0.7	0.9	2.3	1.5	1.5	-1.2	0.3	0.8	0.1	0.3	0.6
Bone: trabecular thickness	0.1	0.1	0.7	0.0	0.3	0.1	-0.1	-0.5	-0.8	0.1	0.3
Bone: trabecular tissue density	0.8	1.1	2.1	1.3	0.9	-1.3	1.2	1.5	0.9	-0.4	0.2
Water consumed over 24 hours	0.8	0.9	2.3	-1.4	-1.5	1.1	-0.6	-0.6	-0.6	0.5	-0.7
Number of responses in last shaping day	1.0	1.0	2.3	1.5	1.0	-1.5	0.8	1.3	0.4	-0.3	0.2