Hub : Genes

Chrm5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Chrm5 0.32 0.23 7.7e-03 0.03 0.04 0.02 0.02 5.9e-02 4.9e-02 1.0e-01 1.1e-01
2 NAcc mRNA stability Chrm5 0.02 0.02 1.7e-04 0.02 0.02 0.02 0.02 6.4e-04 3.6e-04 1.3e-03 9.3e-04
3 pVTA mRNA stability Chrm5 0.03 0.03 3.2e-03 0 0.03 0.01 0.01 1.7e-01 1.7e-03 2.6e-02 2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.30.50.6-0.60.70.8
Area under the delay curve1.11.21.60.9-1.2-1.3
BMI with tail0.62.23.1-1.81.41.2
BMI without tail0.61.93.1-1.81.21.0
Body weight0.10.20.3-0.50.50.5
Weight adjusted by age0.50.71.00.6-0.9-1.0
Bone surface0.51.01.1-0.91.01.1
Bone volume1.01.71.9-1.21.31.4
Breakpoint value in progressive ratio session0.20.20.30.6-0.4-0.3
Number of licking bursts0.30.50.8-0.40.80.9
Context. condit. distance diff. score2.63.13.6-1.51.81.9
Locomotion velocity, session 10.91.01.01.0-1.0-1.0
Locomotion distance, session 10.20.20.40.1-0.5-0.6
Locomotion velocity, session 20.10.10.20.1-0.4-0.4
Locomotion distance, session 20.20.30.50.1-0.6-0.7
Locomotion velocity, session 30.30.40.70.1-0.6-0.8
Locomotion distance, session 30.00.00.00.0-0.1-0.2
Stereotopy head waving bouts, day 31.72.02.4-1.61.41.3
Stereotopy head waving duration, day 32.32.73.3-1.81.61.5
Locomotion velocity, session 74.65.15.4-2.32.22.2
Locomotion distance, session 72.53.23.6-1.61.81.9
Stereotopy head waving bouts, day 71.41.61.81.3-1.3-1.2
Stereotopy head waving duration, day 71.01.21.41.2-1.1-1.0
Locomotion velocity, session 80.70.90.9-1.00.90.9
Locomotion distance, session 81.21.71.9-1.41.31.2
Degree of sensitization distance2.52.63.0-1.41.71.7
Degree of sensitization stereotypy3.64.04.82.2-1.9-1.8
Conditioned locomotion2.12.42.91.3-1.6-1.7
Cocaine response after cond. corrected0.70.91.30.6-1.0-1.1
Cocaine response after cond. not corrected0.50.60.80.5-0.8-0.9
Cocaine response before conditioning0.10.10.1-0.10.30.4
Saline control response0.00.00.00.10.00.1
Bone: connectivity density0.30.50.6-0.70.70.8
Bone: cortical apparent density1.92.64.42.1-1.4-1.1
Bone: cortical area0.60.91.2-1.10.90.9
Bone: cortical porosity0.40.50.90.1-0.7-0.9
Bone: cortical porosity0.40.40.80.1-0.7-0.9
Bone: cortical thickness0.00.00.00.20.00.1
Bone: cortical thickness1.82.12.21.4-1.5-1.5
Bone: cortical tissue density2.33.15.22.3-1.6-1.3
Condit. Reinf. active minus inactive responses0.70.81.4-0.41.01.2
Condit. Reinf. active-inactive response ratio3.43.64.3-1.62.02.1
Condit. Reinf. active responses0.20.20.30.40.30.6
Condit. Reinf. inactive responses1.92.43.31.8-1.5-1.3
Incentive salience index mean1.41.72.6-0.81.41.6
Condit. Reinf. lever presses0.71.01.6-0.51.11.3
Condit. Reinf. active minus inactive responses0.70.80.9-0.90.91.0
Condit. Reinf. active-inactive response ratio1.11.31.4-1.21.11.1
Condit. Reinf. active responses1.01.31.9-0.81.21.4
Condit. Reinf. inactive responses1.11.52.3-0.71.31.5
Condit. Reinf. lever presses0.10.10.20.30.20.4
Condit. Reinf. lever reinforcers received0.40.50.9-0.30.81.0
Conditioned reinforcement - actives0.81.42.01.4-1.1-1.0
Conditioned reinforcement - inactives1.01.51.91.4-1.2-1.1
Conditioned locomotion0.20.30.30.6-0.5-0.5
Patch foraging indifference point 0 sec2.03.64.1-1.72.02.0
Patch foraging indifference point AUC0.91.21.81.3-1.1-0.9
Delay disc. indifference point, 0s delay2.62.93.41.4-1.8-1.9
Delay disc. indifference point, 16s delay0.10.10.2-0.1-0.3-0.5
Delay disc. indifference point, 2s delay0.10.10.20.1-0.4-0.4
Delay disc. indifference point, 24s delay0.60.60.60.8-0.8-0.8
Delay disc. indifference point, 4s delay1.71.81.91.2-1.4-1.4
Delay disc. indifference point, 8s delay0.40.50.70.5-0.7-0.9
Indifference point function ln k0.61.01.8-1.30.90.7
Indifference point function log k0.61.01.8-1.30.90.7
Patch foraging total patch changes 0 sec1.63.13.6-1.51.81.9
Patch foraging total patch changes 12 sec1.01.31.5-1.01.21.2
Patch foraging total patch changes 18 sec0.40.61.21.1-0.6-0.4
Patch foraging total patch changes 24 sec0.00.00.10.20.00.2
Patch foraging total patch changes 6 sec1.32.02.8-1.01.51.7
Patch foraging time to switch 0 sec0.10.10.2-0.50.40.3
Patch foraging water rate 0 sec1.12.32.5-1.41.61.6
Patch foraging water rate 12 sec0.00.00.0-0.00.10.1
Patch foraging water rate 18 sec0.20.40.4-0.60.60.6
Patch foraging water rate 24 sec0.70.91.3-0.71.01.1
Patch foraging water rate 6 sec0.00.00.00.2-0.2-0.2
Seeking ratio, delayed vs. immediate footshock0.91.11.3-0.81.11.2
Distance traveled before self-admin1.52.03.01.7-1.3-1.1
Distance traveled after self-admin0.00.00.0-0.10.10.2
Extensor digitorum longus weight0.20.70.90.9-0.8-0.8
Bone: elastic displacement0.00.00.10.30.10.2
Bone: elastic work0.10.10.1-0.10.30.4
Bone: endosteal estimation0.81.72.5-1.61.21.1
Bone: endosteal perimeter0.40.91.9-1.40.70.5
Epididymis fat weight1.44.96.9-2.62.11.8
Delta time in closed arm before/after self-admin0.80.70.8-0.90.80.8
Delta time in open arm before/after self-admin0.10.10.20.4-0.3-0.3
Diff in mean of infusions in LGA sessions2.42.93.4-1.81.71.6
Delay discount exponential model param0.80.91.1-0.71.01.1
Extinction: sum of active levers before priming0.10.10.20.4-0.3-0.2
Active lever presses in extinction session 61.01.01.40.6-1.1-1.2
Bone: final force2.03.13.4-1.81.81.7
Bone: final moment1.83.03.3-1.81.71.6
Food consumed during 24 hour testing period0.00.00.1-0.10.20.2
Glucose0.50.81.5-1.20.70.6
Heart weight0.10.10.2-0.4-0.1-0.3
Delay discount hyperbolic model param0.80.91.1-0.71.01.1
Intermittent access intake day 1-15 change0.10.20.20.5-0.5-0.5
Intermittent access intake escalation0.20.40.50.7-0.6-0.6
Intermittent access intake escalation 20.20.20.40.6-0.4-0.4
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.10.1
Intermitt. access day 15 inactive lever presses1.32.72.91.7-1.6-1.6
Intermitt. access escalation Index0.71.01.4-1.20.90.8
Intermittent access day 1 total infusions1.11.71.81.3-1.3-1.3
Intermittent access day 15 total infusions1.21.91.91.4-1.4-1.4
Intermittent access terminal intake (last 3 days)0.40.50.50.7-0.7-0.7
Intermittent access total infusions0.81.01.01.0-1.0-1.0
Intermittent access day 1 locomotion0.50.60.80.9-0.8-0.7
Intermittent access day 15 total locomotion0.20.40.50.7-0.6-0.6
Intermittent access total locomotion2.42.93.51.9-1.7-1.5
Intermittent access standard deviation0.20.50.60.8-0.6-0.6
Left kidney weight0.83.64.7-2.21.81.7
Right kidney weight1.14.95.8-2.42.22.0
Cocaine induced anxiety0.71.01.4-1.20.90.8
Post-drug Anxiety3.43.73.8-2.01.91.9
Baseline Anxiety1.01.11.2-1.01.11.1
Tail length0.51.82.01.2-1.4-1.4
Length with tail0.20.91.21.1-0.9-0.8
Length without tail0.10.30.60.8-0.4-0.2
Times rat made contact with spout1.71.92.1-1.51.41.3
Lifetime Intake0.50.60.70.8-0.8-0.7
Liver weight, left2.03.33.4-1.81.81.8
Liver weight, right2.84.95.5-2.02.32.4
Locomotor activity0.10.20.20.2-0.4-0.5
Locomotor testing distance0.20.30.4-0.60.50.5
Locomotor testing rearing0.00.00.0-0.10.10.1
Locomotion in novel chamber0.10.10.2-0.50.30.2
Locomotion in novel chamber post-restriction0.20.30.50.7-0.6-0.5
Fecal boli incidents, locomotor time 11.72.52.81.4-1.6-1.7
Change in fecal boli incidents, locomotor task1.41.42.1-1.51.10.9
Time >=10cm from walls, locomotor time 10.30.40.50.4-0.6-0.7
Bouts of movement, locomotor time 17.28.210.23.2-2.8-2.6
Total resting periods, locomotor time 16.97.79.13.0-2.7-2.6
Rest time, locomotor task time 11.31.61.71.2-1.3-1.3
Distance moved, locomotor task time 12.23.33.8-1.61.91.9
Vertical activity count, locomotor time 12.14.95.6-2.02.32.4
Time >=10cm from walls, locomotor time 21.31.92.5-1.01.51.6
Bouts of movement, locomotor time 20.10.20.50.7-0.4-0.3
Total resting periods, locomotor time 20.20.40.70.8-0.6-0.5
Rest time, locomotor task time 22.12.73.21.4-1.7-1.8
Distance moved, locomotor task time 24.65.57.2-1.82.52.7
Vertical activity count, locomotor time 25.37.39.7-2.02.83.1
Light reinforcement 10.10.20.30.20.40.6
Light reinforcement 20.20.30.50.7-0.4-0.3
Bone: marrow area0.71.62.4-1.51.21.0
Bone: maximum diameter0.81.42.4-1.61.00.8
Bone: maximum force2.24.04.3-2.12.01.9
Bone: maximum moment2.03.53.9-2.01.91.8
Mean time between licks in bursts1.22.83.01.6-1.7-1.7
Mean num. licks in bursts0.10.10.2-0.50.1-0.1
Cd content in liver0.20.30.3-0.50.50.5
Co content in liver1.31.52.10.9-1.3-1.4
Cu content in liver3.13.64.11.7-2.0-2.0
Fe content in liver0.20.20.3-0.50.50.4
K content in liver1.01.01.30.7-1.0-1.1
Mg content in liver2.92.93.01.7-1.7-1.7
Mn content in liver1.11.21.31.1-1.1-1.1
Na content in liver1.92.02.3-1.51.41.3
Rb content in liver3.33.84.92.2-1.9-1.7
Se content in liver2.12.53.41.8-1.5-1.4
Sr content in liver0.50.40.6-0.80.60.6
Zn content in liver1.61.81.81.3-1.3-1.3
Bone: minimum diameter2.03.65.2-2.31.81.6
Time in familiar zone, hab. session 10.80.81.00.7-0.9-1.0
Time in novel zone, hab. session 11.31.31.3-1.11.11.1
Total zone transitions, hab. session 10.10.20.30.1-0.5-0.6
Total locomotion distance, hab. session 10.00.00.1-0.2-0.1-0.3
Locomotion velocity, hab. session 10.00.00.1-0.0-0.2-0.3
Time in familiar zone, hab. session 20.00.00.10.3-0.10.0
Time in novel zone, hab. session 20.40.40.5-0.70.60.5
Total zone transitions, hab. session 21.01.31.60.9-1.2-1.3
Total locomotion distance, hab. session 20.60.81.00.7-0.9-1.0
Locomotion velocity, hab. session 20.60.81.00.6-0.9-1.0
Novel to familiar place preference ratio1.92.13.3-1.81.31.1
Novelty place preference1.92.13.4-1.81.31.1
Time in novel zone, NPP test1.41.52.4-1.51.10.9
Total zone transitions, NPP test4.46.46.62.4-2.6-2.6
Total locomotion distance, NPP test2.43.33.71.7-1.9-1.9
Locomotion velocity, NPP test2.43.34.01.6-1.9-2.0
Intraocular pressure0.20.20.5-0.70.40.3
Delta distance traveled before/after self-admin0.30.30.6-0.80.50.4
Delta ambulatory time before/after self-admin1.21.51.9-1.41.21.1
Parametrial fat weight0.30.61.00.4-0.9-1.0
Pavlov. Cond. lever latency1.62.02.21.3-1.4-1.5
Pavlov. Cond. magazine entry latency4.86.27.1-2.22.62.7
Pavlov. Cond. change in total contacts3.43.64.2-1.62.02.1
Pavlov. Cond. index score3.74.65.4-1.92.22.3
Pavlov. Cond. latency score3.34.24.7-1.92.12.2
Pavlov. Cond. lever contacts1.92.22.5-1.41.51.6
Pavlov. Cond. magazine entry number5.97.48.22.5-2.8-2.9
Pavlov. Cond. intertrial magazine entries0.40.40.50.6-0.7-0.7
Pavlov. Cond. lever-magazine prob. diff.3.44.25.0-1.82.12.2
Pavlov. Cond. response bias2.83.54.2-1.61.92.0
Pavlov. Cond. lever latency0.20.20.20.5-0.5-0.5
Pavlov. Cond. magazine entry latency0.00.00.10.3-0.00.1
Pavlov. Cond. change in total contacts0.30.50.6-0.50.70.7
Pavlov. Cond. index score0.30.30.5-0.40.60.7
Pavlov. Cond. latency score0.20.30.4-0.40.60.6
Pavlov. Cond. lever contacts0.30.50.5-0.70.70.7
Pavlov. Cond. magazine entry number0.10.20.30.0-0.4-0.5
Pavlov. Cond. intertrial magazine entries0.30.40.7-0.30.70.8
Pavlov. Cond. lever-magazine prob. diff.0.30.40.5-0.40.60.7
Pavlov. Cond. response bias0.20.30.4-0.40.60.6
Time in closed arm before self-admin0.60.71.0-0.50.91.0
Time in closed arm after self-admin0.40.40.5-0.50.70.7
Time in open arm before self-admin0.10.10.10.0-0.3-0.4
Time in open arm after self-admin0.00.00.1-0.30.10.0
Bone: periosteal estimation0.71.52.2-1.51.11.0
Bone: periosteal perimeter0.50.92.1-1.50.70.4
Bone: post-yield work0.10.10.3-0.50.1-0.0
Progressive ratio test 1 active lever presses0.20.20.50.7-0.4-0.3
Progressive ratio test 1 breakpoint0.20.20.50.7-0.4-0.3
Progressive ratio test 1 inactive lever presses0.30.40.70.9-0.6-0.5
Progressive ratio test 2 active lever presses0.00.00.00.00.00.1
Progressive ratio test 2 breakpoint0.00.00.00.10.00.0
Progressive ratio test 2 inactive lever presses0.10.10.20.4-0.3-0.3
Incentive Sensitization - Responses0.00.00.0-0.1-0.1-0.1
Incentive Sensitization - Breakpoint0.00.00.0-0.1-0.0-0.1
Sum of active levers in priming session hrs 5-61.61.52.61.6-1.1-0.9
Progressive ratio1.01.61.71.3-1.2-1.2
Food seeking constrained by brief footshock0.00.00.00.10.00.0
Seeking ratio, punishment vs. effort0.30.40.6-0.70.60.6
Retroperitoneal fat weight6.226.631.4-5.65.14.8
Reaction time number correct0.61.11.2-1.01.11.1
Reaction time mean minus median0.00.00.00.0-0.1-0.1
Reaction time mean minus median AUC0.20.50.9-0.90.70.6
Reaction time num false alarms0.10.20.2-0.4-0.2-0.5
Reaction time num false alarms AUC0.10.10.3-0.6-0.1-0.3
Reaction time trials correct on left0.61.11.2-1.01.11.1
Reaction time trials on left0.61.11.2-1.01.11.1
Reaction time mean0.40.60.7-0.70.80.8
Reaction time mean AUC0.30.50.5-0.70.70.7
Median of all reaction times0.50.80.9-0.80.91.0
Reaction time omissions0.00.00.1-0.10.20.2
Reaction time false alarm rate0.40.61.10.1-0.8-1.0
Reaction time premature initiation rate1.21.71.8-1.21.41.4
Reaction time premature initiations2.03.53.9-1.71.92.0
Std. dev. reaction times0.30.50.8-0.90.60.5
Reaction time trials completed0.61.11.2-1.01.11.1
Reaction time trials AUC0.81.51.7-1.11.31.3
Run reversals in cocaine runway, females2.12.12.9-1.71.41.3
Run reversals in cocaine runway, males0.50.50.70.8-0.7-0.6
Latency to leave start box in cocaine runway0.70.80.90.9-0.9-0.8
Latency to leave start box in cocaine runway, F1.31.51.61.2-1.2-1.2
Latency to leave start box in cocaine runway, M0.80.70.8-0.90.90.8
Std. dev. time between licks in bursts0.10.20.3-0.50.40.3
Total sessions with >9 infusions0.40.50.70.8-0.6-0.5
Short access day 1 total inactive lever presses0.81.11.21.0-1.1-1.1
Short access day 10 total inactive lever presses0.10.30.30.4-0.5-0.6
Short access day 1 total infusions0.50.71.41.2-0.7-0.5
Short access day 10 total infusions0.60.81.01.0-0.9-0.8
Short access total infusions0.50.60.91.0-0.7-0.6
Short access day 1 locomotion0.10.10.30.5-0.10.0
Short access day 10 total locomotion1.83.33.31.8-1.8-1.8
Short access total locomotion0.40.50.50.7-0.7-0.7
One hour access (0.3 mA shock)0.40.40.60.5-0.7-0.8
Compulsive drug intake0.30.30.60.2-0.6-0.7
One hour access (shock baseline)0.00.00.0-0.20.20.2
Social response proportion2.42.73.5-1.21.71.9
Social responses1.92.53.4-1.11.71.8
Social time0.60.81.00.8-0.9-1.0
Soleus weight0.30.81.6-1.30.70.6
Bone: stiffness3.25.26.2-2.52.22.1
Tibialis anterior weight0.00.10.20.5-0.3-0.2
Time to tail flick, vehicle, before self-admin0.10.10.1-0.20.40.4
Time to tail flick, vehicle, after self-admin2.12.83.3-1.81.61.6
Time to tail flick, test, before self-admin0.30.30.4-0.30.60.6
Time to tail flick, test, after self-admin0.10.10.20.4-0.3-0.2
Delta time to tail flick, vehicle, before/after SA1.21.11.3-1.11.01.0
Delta time to tail flick, test, before/after SA0.10.10.10.1-0.3-0.3
Tibia length0.00.10.10.4-0.3-0.3
Ambulatory time before self-admin1.62.43.51.9-1.4-1.2
Ambulatory time after self-admin0.00.00.00.10.10.1
Bone: tissue strength0.50.50.60.7-0.7-0.8
Total heroin consumption1.92.22.31.5-1.5-1.4
Bone: trabecular number0.00.00.10.20.00.2
Bone: trabecular spacing1.62.12.3-1.51.51.4
Bone: trabecular thickness0.00.00.10.3-0.1-0.0
Bone: trabecular tissue density0.20.30.60.8-0.4-0.3
Water consumed over 24 hours1.41.92.5-1.01.51.6
Number of responses in last shaping day0.20.20.2-0.40.50.5