Hub : Genes

Chkb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Chkb	0.2	0.09	2.6e-14	0.1	0.09	0.08	0.09	3.5e-11	1.2e-09	1.4e-09	8.6e-10
2	NAcc	gene expression	Chkb	0.03	0.02	4.3e-03	0.02	0.02	0.01	0.01	5.7e-04	6.4e-04	1.8e-03	1.7e-03
3	Adipose	alternative TSS	XM_006242181.5	0.05	0.03	4.5e-06	0.03	0.04	0.04	0.04	6.6e-04	1.3e-05	7.4e-05	5.0e-05
4	Brain	gene expression	Chkb	0.03	0.02	7.9e-03	0.02	0.01	0	0.01	1.1e-02	1.9e-02	2.6e-01	7.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.3	2.5	-1.6	-0.1	-1.4	-0.7
Area under the delay curve	1.3	1.5	2.4	-1.1	-1.0	-1.2	-1.6
BMI with tail	2.2	7.5	15.3	3.9	-2.5	2.6	1.2
BMI without tail	1.4	4.3	7.1	2.7	-0.7	2.5	1.9
Body weight	0.9	3.8	7.5	2.7	-1.7	1.9	1.1
Weight adjusted by age	1.0	1.6	3.0	1.7	-1.7	0.6	-0.2
Bone surface	1.5	2.8	4.2	-1.7	-1.1	-2.1	-1.7
Bone volume	1.4	2.5	4.2	-1.9	-0.6	-2.0	-1.4
Breakpoint value in progressive ratio session	0.2	0.2	0.8	0.3	-0.9	-0.1	-0.3
Number of licking bursts	0.0	0.1	0.1	-0.1	0.3	0.2	0.3
Context. condit. distance diff. score	1.6	1.9	3.1	1.7	-0.1	1.8	1.3
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	-0.5	0.5	0.2
Locomotion distance, session 1	1.3	1.6	3.3	-1.8	0.2	-1.3	-1.2
Locomotion velocity, session 2	0.5	0.6	1.1	1.1	-0.9	0.6	0.3
Locomotion distance, session 2	0.6	0.8	1.7	-1.3	0.2	-1.0	-0.7
Locomotion velocity, session 3	1.8	2.0	3.4	0.5	1.4	1.6	1.8
Locomotion distance, session 3	0.2	0.2	0.3	-0.4	0.5	0.2	0.4
Stereotopy head waving bouts, day 3	1.7	1.9	3.4	-1.5	-0.1	-1.9	-1.4
Stereotopy head waving duration, day 3	0.3	0.4	0.7	-0.8	0.5	-0.8	-0.4
Locomotion velocity, session 7	1.1	1.2	2.4	0.7	0.9	1.1	1.6
Locomotion distance, session 7	0.3	0.4	0.7	0.3	0.4	0.8	0.7
Stereotopy head waving bouts, day 7	0.4	0.5	0.9	-0.9	0.1	-1.0	-0.5
Stereotopy head waving duration, day 7	0.4	0.4	0.7	-0.9	0.8	-0.6	0.2
Locomotion velocity, session 8	1.1	1.3	2.2	1.5	-0.1	1.2	1.3
Locomotion distance, session 8	0.4	0.6	0.9	0.9	-0.9	0.7	0.2
Degree of sensitization distance	0.8	0.8	1.7	1.3	-1.2	0.5	-0.1
Degree of sensitization stereotypy	0.2	0.2	0.3	-0.1	0.6	0.1	0.6
Conditioned locomotion	0.5	0.5	1.3	1.1	0.1	0.8	0.5
Cocaine response after cond. corrected	0.7	0.8	1.2	1.1	-0.5	1.1	0.8
Cocaine response after cond. not corrected	1.8	2.2	3.3	1.8	-0.6	1.8	1.3
Cocaine response before conditioning	0.7	0.9	1.6	1.2	-0.5	1.1	0.8
Saline control response	0.9	1.2	3.7	0.7	-1.9	-0.1	-0.9
Bone: connectivity density	0.4	0.7	1.7	-1.3	0.1	-0.9	-0.3
Bone: cortical apparent density	1.1	1.5	3.1	-1.8	1.3	-1.2	-0.3
Bone: cortical area	0.7	1.1	2.9	0.3	-1.7	-0.7	-0.8
Bone: cortical porosity	1.1	1.2	3.3	0.3	-1.8	-0.4	-1.1
Bone: cortical porosity	1.6	1.7	5.3	0.6	-2.3	-0.2	-1.1
Bone: cortical thickness	0.1	0.2	0.3	-0.4	-0.4	-0.6	-0.3
Bone: cortical thickness	0.5	0.6	0.9	0.5	0.9	0.8	0.9
Bone: cortical tissue density	1.0	1.3	2.6	-1.6	1.2	-1.1	-0.2
Condit. Reinf. active minus inactive responses	0.9	1.1	2.4	1.3	-1.5	0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.5	-0.5	0.2	0.0
Condit. Reinf. active responses	1.4	1.7	3.6	1.9	-1.7	0.7	0.1
Condit. Reinf. inactive responses	0.9	1.1	2.3	1.5	-1.2	0.7	0.2
Incentive salience index mean	1.6	1.9	4.3	1.8	-2.1	0.2	-0.4
Condit. Reinf. lever presses	1.2	1.7	3.6	1.7	-1.9	0.3	-0.4
Condit. Reinf. active minus inactive responses	1.5	1.9	2.9	-0.7	-1.2	-1.7	-1.7
Condit. Reinf. active-inactive response ratio	0.4	0.5	0.7	-0.7	-0.4	-0.8	-0.7
Condit. Reinf. active responses	1.3	1.8	3.0	0.1	-1.7	-1.2	-1.6
Condit. Reinf. inactive responses	0.5	0.7	1.4	0.9	-1.2	0.1	-0.7
Condit. Reinf. lever presses	0.9	1.2	3.6	1.0	-1.9	-0.2	-0.5
Condit. Reinf. lever reinforcers received	1.5	2.0	3.2	-0.0	-1.7	-1.4	-1.8
Conditioned reinforcement - actives	0.4	0.6	1.8	0.7	-1.3	-0.1	-0.5
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.5	-0.1	0.3	0.3
Conditioned locomotion	1.2	1.6	3.1	1.8	-1.2	1.3	0.6
Patch foraging indifference point 0 sec	0.1	0.2	0.4	0.6	-0.7	0.3	-0.1
Patch foraging indifference point AUC	2.7	3.9	6.5	-0.9	-2.0	-2.1	-2.6
Delay disc. indifference point, 0s delay	2.0	2.1	6.0	0.6	-2.5	-0.9	-1.2
Delay disc. indifference point, 16s delay	0.6	0.6	1.3	-0.4	-0.7	-0.8	-1.1
Delay disc. indifference point, 2s delay	5.9	6.6	10.4	-1.9	-2.3	-2.7	-3.2
Delay disc. indifference point, 24s delay	0.2	0.3	0.5	0.6	-0.3	0.7	0.3
Delay disc. indifference point, 4s delay	1.4	1.5	2.5	-1.1	-0.9	-1.3	-1.6
Delay disc. indifference point, 8s delay	0.5	0.6	1.6	-1.3	0.1	-0.6	-0.7
Indifference point function ln k	1.4	2.5	3.6	1.7	0.2	1.9	1.8
Indifference point function log k	1.4	2.5	3.6	1.7	0.2	1.9	1.8
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.4	-0.4	0.2	-0.1
Patch foraging total patch changes 12 sec	1.4	1.8	3.1	-0.0	-1.7	-1.1	-1.8
Patch foraging total patch changes 18 sec	2.0	3.0	5.2	-1.5	-0.8	-2.0	-2.3
Patch foraging total patch changes 24 sec	0.6	1.0	1.7	-0.4	-0.6	-1.2	-1.3
Patch foraging total patch changes 6 sec	1.0	1.5	2.6	-0.2	-1.5	-1.0	-1.6
Patch foraging time to switch 0 sec	0.1	0.2	0.6	-0.5	0.8	-0.3	-0.1
Patch foraging water rate 0 sec	0.3	0.7	1.1	1.0	-0.1	1.0	0.8
Patch foraging water rate 12 sec	0.7	1.4	2.4	1.6	-0.6	1.4	1.0
Patch foraging water rate 18 sec	2.3	3.5	5.3	1.9	0.1	2.3	2.3
Patch foraging water rate 24 sec	1.2	1.7	2.9	1.1	0.4	1.7	1.5
Patch foraging water rate 6 sec	0.5	0.7	1.1	0.8	-0.1	1.1	1.0
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	-0.7	0.5	-0.6	0.0
Distance traveled before self-admin	0.6	0.8	1.7	-1.3	0.4	-1.0	-0.6
Distance traveled after self-admin	0.2	0.2	0.5	-0.0	0.7	0.4	0.5
Extensor digitorum longus weight	0.2	0.8	1.3	1.1	-0.1	1.1	0.8
Bone: elastic displacement	0.3	0.3	0.9	-1.0	-0.2	-0.2	-0.4
Bone: elastic work	0.1	0.2	0.6	-0.0	-0.8	0.1	-0.2
Bone: endosteal estimation	0.3	0.7	2.3	0.4	-1.5	-0.3	-0.7
Bone: endosteal perimeter	2.4	5.2	12.9	0.6	-3.6	-1.6	-2.2
Epididymis fat weight	1.0	3.5	6.9	2.6	-2.6	0.5	-0.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	-0.2	-0.4	-0.1	-0.7
Delta time in open arm before/after self-admin	0.0	0.0	0.2	0.1	0.1	-0.2	0.4
Diff in mean of infusions in LGA sessions	1.2	1.4	4.0	1.1	-2.0	-0.2	-0.7
Delay discount exponential model param	0.9	1.0	1.7	1.0	0.7	0.9	1.3
Extinction: sum of active levers before priming	0.6	0.7	1.2	-0.5	-0.8	-0.8	-1.1
Active lever presses in extinction session 6	1.3	1.3	2.6	1.6	-0.8	1.2	0.7
Bone: final force	0.2	0.4	0.5	-0.6	-0.4	-0.7	-0.7
Bone: final moment	0.2	0.4	0.6	-0.8	-0.3	-0.7	-0.6
Food consumed during 24 hour testing period	0.9	1.3	2.1	1.5	-0.6	1.4	0.9
Glucose	0.4	0.6	0.9	-0.6	-0.9	-0.8	-0.9
Heart weight	0.6	1.0	1.8	0.8	0.6	1.0	1.3
Delay discount hyperbolic model param	1.3	1.5	2.4	1.2	0.8	1.2	1.5
Intermittent access intake day 1-15 change	0.2	0.5	1.0	1.0	-0.9	0.4	-0.1
Intermittent access intake escalation	0.2	0.5	1.0	1.0	-0.9	0.3	-0.1
Intermittent access intake escalation 2	1.4	1.6	3.9	1.3	-2.0	-0.3	-0.7
Intermitt. access day 1 inactive lever presses	0.2	0.6	1.5	0.8	-1.2	0.1	-0.3
Intermitt. access day 15 inactive lever presses	1.4	2.8	4.2	2.1	0.3	2.0	1.7
Intermitt. access escalation Index	0.3	0.4	1.0	-0.5	1.0	0.0	0.4
Intermittent access day 1 total infusions	0.1	0.2	0.4	0.1	0.4	0.6	0.5
Intermittent access day 15 total infusions	0.1	0.1	0.2	0.5	-0.2	0.4	0.2
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.4	1.2	-1.2	0.5	-0.0
Intermittent access total infusions	0.1	0.1	0.2	0.4	-0.4	0.4	0.1
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.1	-0.3	-0.0	-0.2
Intermittent access day 15 total locomotion	0.4	0.7	1.4	1.0	-1.2	0.6	-0.1
Intermittent access total locomotion	0.4	0.5	0.9	0.9	-0.5	0.9	0.3
Intermittent access standard deviation	0.3	0.6	1.0	0.7	0.5	0.8	1.0
Left kidney weight	2.4	11.3	23.0	4.8	-3.3	3.0	1.6
Right kidney weight	3.8	17.4	35.1	5.9	-3.4	4.1	2.5
Cocaine induced anxiety	0.6	0.8	1.3	1.2	0.2	1.1	0.9
Post-drug Anxiety	1.2	1.3	1.9	1.3	0.4	1.4	1.2
Baseline Anxiety	0.2	0.2	0.4	-0.6	0.6	-0.3	-0.1
Tail length	0.2	0.8	1.7	-1.3	0.7	-1.0	-0.3
Length with tail	0.1	0.2	0.5	-0.3	-0.4	-0.7	-0.5
Length without tail	0.3	1.1	3.0	0.5	-1.7	-0.5	-0.9
Times rat made contact with spout	3.0	3.4	4.8	0.9	1.8	2.2	2.2
Lifetime Intake	0.2	0.2	0.4	0.5	-0.3	0.6	0.3
Liver weight, left	0.5	0.8	2.2	0.3	-1.5	-0.5	-0.7
Liver weight, right	0.2	0.4	0.7	-0.4	-0.6	-0.6	-0.8
Locomotor activity	0.9	1.3	3.6	0.5	-1.9	-0.6	-1.1
Locomotor testing distance	0.2	0.4	0.7	-0.8	0.2	-0.7	-0.6
Locomotor testing rearing	2.0	4.0	6.9	-0.6	-2.3	-1.9	-2.6
Locomotion in novel chamber	2.4	3.1	4.5	1.5	1.2	2.1	2.1
Locomotion in novel chamber post-restriction	0.5	0.8	1.7	-0.3	-0.9	-0.8	-1.3
Fecal boli incidents, locomotor time 1	0.2	0.3	0.7	-0.8	0.5	-0.2	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.5	-0.3	0.1	0.1
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	0.6	-0.8	-0.3	-0.4
Bouts of movement, locomotor time 1	0.4	0.4	0.5	0.7	0.4	0.7	0.7
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.3	0.6	0.5	0.5
Rest time, locomotor task time 1	0.8	1.0	2.6	-0.0	1.6	1.0	0.7
Distance moved, locomotor task time 1	0.4	0.6	1.8	0.4	-1.3	-0.5	-0.2
Vertical activity count, locomotor time 1	0.6	1.3	4.2	0.9	-2.1	-0.4	-0.2
Time >=10cm from walls, locomotor time 2	0.7	1.1	2.0	1.4	-1.4	0.4	0.3
Bouts of movement, locomotor time 2	0.1	0.2	0.3	-0.6	0.4	-0.4	-0.2
Total resting periods, locomotor time 2	0.1	0.2	0.4	-0.6	0.2	-0.5	-0.5
Rest time, locomotor task time 2	0.8	1.0	3.2	-0.8	1.8	0.2	0.5
Distance moved, locomotor task time 2	1.3	1.5	4.3	1.3	-2.1	0.3	-0.2
Vertical activity count, locomotor time 2	1.3	1.7	4.7	1.4	-2.2	0.2	-0.4
Light reinforcement 1	0.4	0.9	2.6	0.8	-1.6	-0.0	-0.5
Light reinforcement 2	1.6	2.4	7.3	1.4	-2.7	0.1	-0.6
Bone: marrow area	0.3	0.7	2.0	0.3	-1.4	-0.4	-0.7
Bone: maximum diameter	0.8	1.5	3.7	1.5	-1.9	0.1	-0.4
Bone: maximum force	0.1	0.2	0.3	-0.6	-0.4	-0.4	-0.4
Bone: maximum moment	0.1	0.2	0.5	-0.7	-0.3	-0.4	-0.3
Mean time between licks in bursts	0.7	1.7	3.6	-1.7	1.9	-0.6	0.1
Mean num. licks in bursts	0.3	0.5	0.6	0.3	0.8	0.8	0.8
Cd content in liver	0.5	0.6	1.0	-0.8	-0.1	-0.8	-1.0
Co content in liver	0.5	0.5	1.8	0.2	-1.3	-0.1	-0.5
Cu content in liver	2.3	2.7	7.1	-0.4	2.7	1.0	1.6
Fe content in liver	0.5	0.6	1.2	-0.7	-0.6	-0.7	-1.1
K content in liver	0.0	0.0	0.1	0.0	0.2	-0.4	-0.0
Mg content in liver	0.7	0.8	1.3	-0.7	-0.5	-1.1	-1.0
Mn content in liver	0.1	0.1	0.3	0.1	-0.5	-0.4	-0.2
Na content in liver	3.9	4.2	7.4	-2.2	-0.0	-2.7	-2.1
Rb content in liver	0.4	0.5	1.0	-0.1	-0.9	-0.6	-1.0
Se content in liver	0.4	0.4	0.7	0.9	0.2	0.8	0.6
Sr content in liver	1.0	0.9	2.2	-1.1	1.5	-0.2	0.3
Zn content in liver	0.7	0.8	2.2	-0.4	1.5	0.6	0.7
Bone: minimum diameter	0.4	0.8	2.2	0.3	-1.5	-0.5	-0.7
Time in familiar zone, hab. session 1	1.1	1.0	1.7	0.6	0.7	1.3	1.3
Time in novel zone, hab. session 1	1.3	1.3	1.9	-1.0	-0.6	-1.3	-1.4
Total zone transitions, hab. session 1	1.5	2.2	3.6	-1.9	0.5	-1.7	-1.4
Total locomotion distance, hab. session 1	0.5	0.7	1.3	-0.5	-0.8	-0.7	-1.2
Locomotion velocity, hab. session 1	0.7	1.0	1.8	-0.6	-0.9	-1.0	-1.4
Time in familiar zone, hab. session 2	1.8	1.9	2.9	1.4	0.4	1.7	1.6
Time in novel zone, hab. session 2	1.3	1.3	2.2	-1.5	0.0	-1.4	-1.1
Total zone transitions, hab. session 2	0.2	0.2	0.5	0.3	0.3	0.7	0.4
Total locomotion distance, hab. session 2	0.5	0.7	1.0	1.0	-0.9	1.0	0.1
Locomotion velocity, hab. session 2	0.4	0.6	0.9	0.9	-1.0	0.8	-0.0
Novel to familiar place preference ratio	0.5	0.6	1.4	-0.1	1.2	0.4	0.9
Novelty place preference	0.6	0.7	1.2	0.0	1.1	0.7	1.0
Time in novel zone, NPP test	0.9	1.0	1.8	-0.0	1.4	0.8	1.2
Total zone transitions, NPP test	0.3	0.4	0.9	-1.0	0.6	-0.6	-0.3
Total locomotion distance, NPP test	0.3	0.4	0.8	-0.0	-0.9	-0.3	-0.8
Locomotion velocity, NPP test	0.2	0.3	0.8	0.1	-0.9	-0.2	-0.7
Intraocular pressure	0.7	1.0	2.0	-0.0	-1.4	-0.6	-1.3
Delta distance traveled before/after self-admin	3.0	3.2	4.8	2.1	0.3	2.2	1.8
Delta ambulatory time before/after self-admin	1.7	2.1	3.6	1.7	0.4	1.9	1.4
Parametrial fat weight	0.1	0.2	0.6	0.6	-0.8	0.2	-0.1
Pavlov. Cond. lever latency	1.0	1.2	2.5	-1.6	1.5	-0.4	0.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.0	0.1	-0.5	-0.5
Pavlov. Cond. change in total contacts	0.5	0.5	0.8	0.3	-0.9	-0.7	-0.9
Pavlov. Cond. index score	0.1	0.2	0.3	0.5	-0.4	-0.3	-0.5
Pavlov. Cond. latency score	0.2	0.3	0.6	0.7	-0.6	-0.2	-0.4
Pavlov. Cond. lever contacts	0.9	1.1	2.4	1.5	-1.4	0.4	-0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.6	0.3	0.0	0.7	0.8
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.2	1.2	-1.5	0.4	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.4	-0.3	-0.4	-0.6
Pavlov. Cond. response bias	0.2	0.3	0.5	0.7	-0.7	0.0	-0.4
Pavlov. Cond. lever latency	0.7	1.0	1.9	-1.4	0.7	-0.9	-0.9
Pavlov. Cond. magazine entry latency	0.3	0.3	0.8	0.9	-0.3	0.3	0.5
Pavlov. Cond. change in total contacts	0.4	0.7	1.2	-0.1	-1.1	-0.9	-0.9
Pavlov. Cond. index score	0.3	0.5	1.0	1.0	-0.7	0.3	0.5
Pavlov. Cond. latency score	0.6	0.8	1.7	1.3	-0.8	0.6	0.7
Pavlov. Cond. lever contacts	0.8	1.0	2.0	1.4	-0.8	0.9	0.8
Pavlov. Cond. magazine entry number	0.4	0.5	1.3	-1.1	0.6	-0.4	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	-0.1	0.6	0.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	1.1	-0.7	0.4	0.5
Pavlov. Cond. response bias	0.2	0.3	0.6	0.8	-0.6	0.2	0.4
Time in closed arm before self-admin	2.1	2.7	4.4	-1.0	-1.5	-2.1	-1.8
Time in closed arm after self-admin	2.5	2.7	4.2	-0.5	-2.0	-1.5	-2.0
Time in open arm before self-admin	0.4	0.5	1.4	-0.1	1.2	0.6	0.4
Time in open arm after self-admin	0.1	0.1	0.2	0.1	0.4	0.2	0.4
Bone: periosteal estimation	0.7	1.4	3.9	0.4	-2.0	-0.7	-1.0
Bone: periosteal perimeter	1.7	3.0	8.4	0.8	-2.9	-1.0	-1.4
Bone: post-yield work	0.6	0.8	1.9	-1.1	1.4	-0.2	0.2
Progressive ratio test 1 active lever presses	0.7	0.8	1.2	0.1	1.1	0.9	1.1
Progressive ratio test 1 breakpoint	0.6	0.7	1.2	0.1	1.1	0.8	1.0
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.3	-0.4	-0.0	-0.1
Progressive ratio test 2 active lever presses	0.5	0.5	1.0	1.0	-0.6	0.8	0.4
Progressive ratio test 2 breakpoint	0.4	0.4	0.7	0.8	-0.5	0.7	0.3
Progressive ratio test 2 inactive lever presses	0.4	0.6	1.1	1.0	-1.0	0.5	0.0
Incentive Sensitization - Responses	0.8	1.1	2.8	1.1	-1.7	0.2	-0.4
Incentive Sensitization - Breakpoint	0.8	1.0	2.6	1.1	-1.6	0.2	-0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.3	-0.5	0.0	-0.3
Progressive ratio	0.2	0.3	0.5	0.7	-0.1	0.7	0.5
Food seeking constrained by brief footshock	1.6	1.9	3.5	1.9	-1.4	1.5	0.3
Seeking ratio, punishment vs. effort	0.3	0.4	0.8	-0.0	-0.9	-0.5	-0.8
Retroperitoneal fat weight	1.2	5.3	10.9	3.3	-2.7	1.7	0.2
Reaction time number correct	0.2	0.4	0.8	-0.9	0.4	-0.3	-0.7
Reaction time mean minus median	0.1	0.1	0.5	0.1	-0.7	-0.0	-0.1
Reaction time mean minus median AUC	0.1	0.1	0.2	0.4	-0.4	0.3	0.2
Reaction time num false alarms	0.0	0.1	0.2	-0.2	-0.1	-0.4	-0.2
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.1	0.3	0.2	0.3
Reaction time trials correct on left	0.2	0.4	0.8	-0.9	0.4	-0.3	-0.7
Reaction time trials on left	0.2	0.4	0.9	-0.9	0.5	-0.3	-0.7
Reaction time mean	0.5	0.8	1.7	-0.3	1.3	0.5	1.1
Reaction time mean AUC	0.4	0.7	1.5	-0.4	1.2	0.3	1.0
Median of all reaction times	1.2	1.7	3.7	-0.3	1.9	0.8	1.6
Reaction time omissions	0.2	0.3	0.6	-0.6	0.8	0.1	0.4
Reaction time false alarm rate	0.0	0.0	0.1	0.2	-0.0	0.0	0.3
Reaction time premature initiation rate	2.6	3.5	10.0	1.8	-3.2	-0.2	-0.9
Reaction time premature initiations	1.1	1.9	5.5	1.0	-2.3	-0.3	-1.1
Std. dev. reaction times	0.1	0.2	0.5	0.2	0.2	0.5	0.7
Reaction time trials completed	0.2	0.4	0.9	-0.9	0.5	-0.3	-0.7
Reaction time trials AUC	0.1	0.3	0.6	-0.8	0.4	-0.1	-0.5
Run reversals in cocaine runway, females	0.4	0.4	0.7	0.3	0.7	0.7	0.9
Run reversals in cocaine runway, males	0.9	0.9	1.5	-1.0	-0.6	-0.8	-1.2
Latency to leave start box in cocaine runway	1.7	2.0	3.6	1.6	0.1	1.9	1.3
Latency to leave start box in cocaine runway, F	4.3	5.0	7.1	2.3	1.1	2.7	2.5
Latency to leave start box in cocaine runway, M	0.8	0.7	1.4	-0.2	-1.2	-0.4	-1.1
Std. dev. time between licks in bursts	0.8	1.1	3.1	0.9	-1.7	0.1	-0.6
Total sessions with >9 infusions	0.6	0.7	1.5	0.5	0.4	1.2	0.9
Short access day 1 total inactive lever presses	2.7	3.5	6.0	2.4	-0.4	2.3	1.6
Short access day 10 total inactive lever presses	1.6	3.8	8.2	2.9	-2.4	1.1	0.3
Short access day 1 total infusions	1.1	1.5	2.8	1.1	0.3	1.7	1.3
Short access day 10 total infusions	0.7	0.9	1.7	1.1	-0.2	1.3	0.9
Short access total infusions	0.7	0.8	1.7	0.9	-0.1	1.3	0.8
Short access day 1 locomotion	1.0	1.3	2.1	1.2	0.3	1.5	1.2
Short access day 10 total locomotion	0.4	0.8	1.3	1.1	-0.4	1.2	0.7
Short access total locomotion	0.5	0.6	1.1	0.8	-0.3	1.0	0.6
One hour access (0.3 mA shock)	0.7	0.8	2.3	0.9	-1.5	-0.0	-0.4
Compulsive drug intake	0.0	0.0	0.0	-0.1	-0.2	0.0	-0.0
One hour access (shock baseline)	0.3	0.5	1.3	0.6	-1.1	-0.1	-0.4
Social response proportion	0.4	0.5	0.7	-0.5	-0.4	-0.8	-0.8
Social responses	0.3	0.4	0.6	-0.1	-0.7	-0.8	-0.8
Social time	0.8	1.1	2.0	0.8	0.8	1.4	1.1
Soleus weight	0.7	2.0	3.5	1.9	-0.3	1.6	1.4
Bone: stiffness	0.1	0.2	0.6	-0.8	0.3	-0.5	-0.0
Tibialis anterior weight	0.0	0.1	0.1	0.2	0.1	0.4	0.2
Time to tail flick, vehicle, before self-admin	0.9	1.0	2.1	1.4	-1.4	0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.8	0.9	-0.8	0.1	0.0
Time to tail flick, test, before self-admin	0.2	0.2	0.5	0.7	-0.6	0.0	0.3
Time to tail flick, test, after self-admin	2.5	2.6	4.2	2.1	-0.0	1.7	1.7
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	-0.8	0.8	-0.3	-0.1
Delta time to tail flick, test, before/after SA	0.5	0.5	1.0	0.6	0.4	1.0	0.7
Tibia length	1.0	2.9	6.1	-2.5	1.2	-1.7	-0.9
Ambulatory time before self-admin	0.2	0.3	0.7	-0.6	0.8	-0.0	0.3
Ambulatory time after self-admin	0.5	0.6	0.8	0.5	0.8	0.9	0.8
Bone: tissue strength	0.8	0.8	2.1	-1.5	1.0	-0.1	0.0
Total heroin consumption	0.2	0.2	0.7	0.3	-0.8	0.0	-0.3
Bone: trabecular number	0.5	0.9	2.3	-1.5	-0.1	-1.0	-0.5
Bone: trabecular spacing	1.2	1.6	3.6	1.9	-0.5	1.5	0.7
Bone: trabecular thickness	0.7	0.8	1.2	-0.4	-1.1	-1.0	-0.9
Bone: trabecular tissue density	1.1	1.6	2.9	-1.7	1.0	-1.3	-0.8
Water consumed over 24 hours	0.1	0.1	0.2	0.0	-0.2	0.4	0.3
Number of responses in last shaping day	0.3	0.3	0.8	-0.4	0.9	0.4	0.4