Hub : Genes

Cgm4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Cgm4	0.77	0.12	0.0e+00	0.45	0.44	0.45	0.46	7.8e-46	1.6e-45	1.0e-46	7.0e-47
2	LHb	gene expression	Cgm4	0.85	0.4	5.6e-17	0.53	0.55	0.55	0.56	1.1e-14	1.2e-15	1.5e-15	9.3e-16
3	BLA	gene expression	Cgm4	0.43	0.11	0.0e+00	0.42	0.41	0.39	0.4	4.8e-24	2.8e-23	4.6e-22	8.1e-23
4	NAcc	gene expression	Cgm4	0.16	0.1	0.0e+00	0.18	0.16	0.16	0.17	5.6e-26	5.5e-24	4.1e-24	9.3e-26

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1
Area under the delay curve	0.5	0.8	0.9	-0.9	-0.9	1.0	0.8
BMI with tail	1.0	3.5	4.3	2.1	2.1	-1.7	-1.6
BMI without tail	0.9	4.8	5.7	2.4	2.4	-2.0	-2.0
Body weight	2.1	9.1	10.4	3.2	3.2	-2.8	-2.8
Weight adjusted by age	0.0	0.1	0.2	0.4	0.4	-0.3	-0.3
Bone surface	0.6	1.2	1.2	1.1	1.1	-1.1	-1.1
Bone volume	0.3	0.6	0.7	0.8	0.8	-0.8	-0.8
Breakpoint value in progressive ratio session	2.1	3.9	4.4	-2.1	-2.1	1.8	1.8
Number of licking bursts	1.4	4.4	4.6	2.1	2.1	-2.1	-2.0
Context. condit. distance diff. score	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1
Locomotion velocity, session 1	0.2	0.2	0.3	-0.4	-0.4	0.6	0.5
Locomotion distance, session 1	0.0	0.0	0.0	-0.1	-0.1	0.1	0.0
Locomotion velocity, session 2	1.8	2.2	2.4	1.5	1.6	-1.4	-1.4
Locomotion distance, session 2	0.4	0.6	0.7	0.9	0.9	-0.6	-0.7
Locomotion velocity, session 3	0.3	0.3	0.4	0.6	0.7	-0.5	-0.6
Locomotion distance, session 3	0.9	1.0	1.0	-1.0	-1.0	1.0	1.0
Stereotopy head waving bouts, day 3	1.0	1.2	1.5	1.1	1.1	-1.0	-1.2
Stereotopy head waving duration, day 3	0.8	0.9	1.3	0.9	0.9	-0.9	-1.2
Locomotion velocity, session 7	0.7	0.8	0.8	-0.9	-0.9	0.9	0.8
Locomotion distance, session 7	0.0	0.0	0.1	0.2	0.2	-0.2	-0.2
Stereotopy head waving bouts, day 7	0.7	0.8	1.1	0.8	0.8	-0.8	-1.1
Stereotopy head waving duration, day 7	0.6	0.8	1.0	0.8	0.9	-0.7	-1.0
Locomotion velocity, session 8	0.0	0.0	0.1	-0.1	-0.1	0.2	0.2
Locomotion distance, session 8	0.0	0.0	0.0	0.1	0.2	0.0	-0.2
Degree of sensitization distance	0.9	1.0	1.1	1.1	1.0	-0.9	-1.0
Degree of sensitization stereotypy	0.7	0.8	1.1	0.9	0.9	-0.8	-1.0
Conditioned locomotion	0.1	0.2	0.2	-0.5	-0.5	0.3	0.3
Cocaine response after cond. corrected	0.3	0.4	0.4	0.7	0.7	-0.6	-0.6
Cocaine response after cond. not corrected	0.9	1.3	1.4	1.2	1.2	-1.0	-1.1
Cocaine response before conditioning	1.9	2.3	2.8	1.7	1.6	-1.4	-1.4
Saline control response	1.5	2.1	2.2	1.5	1.5	-1.4	-1.4
Bone: connectivity density	0.0	0.0	0.1	0.2	0.2	-0.3	-0.1
Bone: cortical apparent density	0.0	0.1	0.1	-0.3	-0.3	0.2	0.1
Bone: cortical area	1.9	3.0	3.3	1.8	1.8	-1.7	-1.7
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	0.3	0.4
Bone: cortical porosity	0.0	0.0	0.0	0.0	0.0	-0.1	-0.0
Bone: cortical thickness	0.5	0.9	1.0	1.0	1.0	-0.9	-0.9
Bone: cortical thickness	0.9	1.1	1.3	1.1	1.2	-1.1	-0.9
Bone: cortical tissue density	0.1	0.1	0.2	-0.4	-0.4	0.3	0.2
Condit. Reinf. active minus inactive responses	0.8	0.9	1.2	1.1	1.1	-0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.1	1.1	1.1	-0.8	-0.7
Condit. Reinf. active responses	0.4	0.5	0.8	0.9	0.9	-0.6	-0.4
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.3	-0.3	0.3	0.4
Incentive salience index mean	0.7	0.8	1.1	1.1	1.1	-0.8	-0.6
Condit. Reinf. lever presses	0.2	0.4	0.4	0.7	0.7	-0.6	-0.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	0.2	0.2	-0.3	-0.3
Condit. Reinf. active responses	0.1	0.1	0.1	-0.3	-0.3	0.3	0.4
Condit. Reinf. inactive responses	0.3	0.5	0.6	-0.7	-0.7	0.8	0.8
Condit. Reinf. lever presses	0.1	0.1	0.2	0.4	0.4	-0.3	-0.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4
Conditioned reinforcement - actives	1.2	4.6	4.9	2.2	2.2	-2.2	-2.1
Conditioned reinforcement - inactives	0.9	2.5	3.7	1.9	1.9	-1.1	-1.2
Conditioned locomotion	1.7	2.5	2.6	1.6	1.6	-1.6	-1.6
Patch foraging indifference point 0 sec	0.1	0.4	0.6	0.7	0.7	-0.5	-0.6
Patch foraging indifference point AUC	2.5	6.0	7.4	2.7	2.7	-2.3	-2.0
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.7	-0.6	0.6	0.4
Delay disc. indifference point, 16s delay	0.2	0.3	0.4	-0.5	-0.5	0.6	0.6
Delay disc. indifference point, 2s delay	1.7	1.9	2.3	-1.4	-1.3	1.5	1.4
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	0.1	0.1	0.1	-0.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	0.5	0.6	-0.4	-0.5
Delay disc. indifference point, 8s delay	1.0	1.6	1.8	-1.3	-1.3	1.2	1.1
Indifference point function ln k	1.1	3.3	3.7	-1.8	-1.8	1.9	1.7
Indifference point function log k	1.1	3.3	3.7	-1.8	-1.8	1.9	1.7
Patch foraging total patch changes 0 sec	0.2	0.6	0.7	0.8	0.9	-0.6	-0.7
Patch foraging total patch changes 12 sec	2.1	2.8	3.8	2.0	1.9	-1.5	-1.3
Patch foraging total patch changes 18 sec	1.3	3.0	3.7	1.9	1.9	-1.5	-1.5
Patch foraging total patch changes 24 sec	0.4	1.5	1.8	1.3	1.3	-1.1	-0.9
Patch foraging total patch changes 6 sec	2.1	3.5	4.4	2.1	2.1	-1.7	-1.6
Patch foraging time to switch 0 sec	1.0	3.7	3.9	-1.9	-2.0	1.9	1.9
Patch foraging water rate 0 sec	1.2	4.6	4.9	2.2	2.2	-2.1	-2.1
Patch foraging water rate 12 sec	0.0	0.1	0.1	0.2	0.2	-0.3	-0.3
Patch foraging water rate 18 sec	0.0	0.1	0.1	0.1	0.2	-0.3	-0.3
Patch foraging water rate 24 sec	0.0	0.0	0.1	-0.0	0.1	-0.2	-0.3
Patch foraging water rate 6 sec	0.7	1.0	1.2	0.9	0.9	-1.0	-1.1
Seeking ratio, delayed vs. immediate footshock	2.2	3.1	3.5	-1.7	-1.7	1.8	1.9
Distance traveled before self-admin	0.0	0.0	0.1	0.1	0.1	-0.2	-0.3
Distance traveled after self-admin	0.4	0.8	1.1	-1.0	-1.0	0.7	0.6
Extensor digitorum longus weight	2.5	10.1	10.2	3.2	3.2	-3.2	-3.1
Bone: elastic displacement	0.9	1.1	1.2	-1.0	-1.0	1.1	1.1
Bone: elastic work	0.1	0.1	0.2	0.4	0.4	-0.2	-0.2
Bone: endosteal estimation	0.0	0.0	0.0	0.0	0.0	0.1	0.1
Bone: endosteal perimeter	0.1	0.1	0.2	0.4	0.4	-0.3	-0.3
Epididymis fat weight	0.1	0.5	1.0	-0.5	-0.5	0.7	1.0
Delta time in closed arm before/after self-admin	0.7	0.6	0.7	-0.8	-0.7	0.8	0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.5	0.4	-0.4	-0.5
Diff in mean of infusions in LGA sessions	1.5	2.7	3.2	-1.8	-1.8	1.5	1.5
Delay discount exponential model param	0.4	0.5	0.7	0.7	0.7	-0.8	-0.7
Extinction: sum of active levers before priming	0.0	0.1	0.1	-0.1	-0.1	0.3	0.3
Active lever presses in extinction session 6	0.3	0.3	0.3	0.6	0.6	-0.5	-0.5
Bone: final force	0.6	1.0	1.2	1.1	1.1	-1.0	-0.9
Bone: final moment	1.0	1.6	1.8	1.3	1.3	-1.2	-1.2
Food consumed during 24 hour testing period	3.7	7.4	7.8	-2.8	-2.8	2.6	2.7
Glucose	0.8	1.2	1.4	-1.2	-1.2	1.0	1.1
Heart weight	1.4	2.2	2.6	1.5	1.5	-1.3	-1.6
Delay discount hyperbolic model param	0.3	0.4	0.6	0.6	0.6	-0.8	-0.6
Intermittent access intake day 1-15 change	0.1	0.3	0.4	0.5	0.5	-0.6	-0.5
Intermittent access intake escalation	0.1	0.5	0.6	0.7	0.7	-0.8	-0.7
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1
Intermitt. access day 1 inactive lever presses	0.1	0.6	0.9	1.0	0.9	-0.5	-0.8
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.7	0.8	0.8	-0.1	0.2
Intermitt. access escalation Index	0.1	0.4	0.5	-0.6	-0.6	0.6	0.7
Intermittent access day 1 total infusions	1.1	3.4	4.0	1.9	2.0	-1.8	-1.6
Intermittent access day 15 total infusions	0.6	1.4	1.7	1.3	1.3	-1.2	-1.0
Intermittent access terminal intake (last 3 days)	0.7	1.2	1.5	1.2	1.2	-1.1	-1.0
Intermittent access total infusions	2.2	2.6	3.0	1.7	1.7	-1.6	-1.4
Intermittent access day 1 locomotion	0.4	0.7	1.1	1.0	1.0	-0.6	-0.6
Intermittent access day 15 total locomotion	0.0	0.1	0.3	0.5	0.5	-0.2	-0.1
Intermittent access total locomotion	1.6	1.9	2.5	1.5	1.6	-1.2	-1.1
Intermittent access standard deviation	0.1	0.4	0.6	-0.8	-0.7	0.5	0.3
Left kidney weight	3.5	27.8	30.0	5.5	5.4	-5.0	-5.1
Right kidney weight	3.4	24.1	26.2	5.1	5.1	-4.7	-4.7
Cocaine induced anxiety	0.0	0.0	0.0	-0.2	-0.2	0.0	0.0
Post-drug Anxiety	0.0	0.0	0.1	-0.3	-0.3	0.1	0.1
Baseline Anxiety	0.6	1.0	1.1	-1.0	-1.0	1.0	1.0
Tail length	0.7	3.8	4.2	2.1	2.0	-1.9	-1.9
Length with tail	0.8	3.5	3.8	1.9	1.9	-1.8	-1.8
Length without tail	0.3	1.7	1.9	1.4	1.4	-1.3	-1.2
Times rat made contact with spout	0.3	0.3	0.4	-0.6	-0.5	0.6	0.6
Lifetime Intake	2.4	3.0	3.4	1.8	1.9	-1.7	-1.6
Liver weight, left	3.0	5.1	5.8	2.4	2.4	-2.1	-2.1
Liver weight, right	2.2	3.8	4.1	1.9	1.9	-1.9	-2.0
Locomotor activity	1.8	2.9	3.2	1.8	1.8	-1.5	-1.7
Locomotor testing distance	1.1	2.7	3.2	1.8	1.8	-1.3	-1.6
Locomotor testing rearing	3.0	10.9	12.4	3.5	3.5	-3.0	-3.2
Locomotion in novel chamber	1.1	1.5	1.7	-1.2	-1.2	1.1	1.3
Locomotion in novel chamber post-restriction	0.6	1.8	2.4	-1.3	-1.2	1.5	1.2
Fecal boli incidents, locomotor time 1	0.2	0.4	0.7	0.7	0.8	-0.3	-0.6
Change in fecal boli incidents, locomotor task	0.9	0.9	1.2	-1.0	-1.1	0.9	0.9
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.1	0.2	0.1	0.2
Bouts of movement, locomotor time 1	3.3	4.3	4.6	-2.0	-2.1	2.1	2.0
Total resting periods, locomotor time 1	4.4	5.1	5.8	-2.2	-2.2	2.4	2.3
Rest time, locomotor task time 1	0.3	0.5	0.9	-0.4	-0.4	0.9	0.8
Distance moved, locomotor task time 1	0.4	1.0	1.7	0.8	0.8	-1.3	-1.1
Vertical activity count, locomotor time 1	0.0	0.3	0.5	0.4	0.3	-0.7	-0.7
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	0.2	0.3	0.1	0.3
Bouts of movement, locomotor time 2	2.7	8.9	9.2	-3.0	-3.0	2.9	3.0
Total resting periods, locomotor time 2	2.2	8.8	9.2	-3.0	-2.9	2.9	3.0
Rest time, locomotor task time 2	0.4	0.6	0.9	-0.8	-0.7	0.9	0.8
Distance moved, locomotor task time 2	1.0	1.4	2.2	1.0	1.0	-1.5	-1.2
Vertical activity count, locomotor time 2	0.1	0.3	0.5	0.2	0.1	-0.7	-0.7
Light reinforcement 1	0.1	0.2	0.4	0.6	0.6	-0.3	-0.4
Light reinforcement 2	0.5	1.1	1.2	1.1	1.0	-1.0	-1.1
Bone: marrow area	0.0	0.0	0.0	0.1	0.1	-0.0	0.0
Bone: maximum diameter	2.5	5.0	5.2	2.3	2.3	-2.2	-2.2
Bone: maximum force	0.3	0.6	0.6	0.8	0.8	-0.8	-0.7
Bone: maximum moment	0.5	0.9	1.0	0.9	1.0	-1.0	-0.9
Mean time between licks in bursts	0.0	0.0	0.0	-0.1	-0.1	0.0	0.1
Mean num. licks in bursts	2.3	6.3	6.5	-2.6	-2.5	2.5	2.4
Cd content in liver	0.4	0.4	0.6	-0.6	-0.6	0.7	0.8
Co content in liver	1.2	1.4	1.4	-1.2	-1.2	1.2	1.2
Cu content in liver	0.6	0.7	0.7	0.8	0.8	-0.9	-0.9
Fe content in liver	3.4	4.2	4.4	2.1	2.1	-2.0	-2.0
K content in liver	0.4	0.4	0.5	0.6	0.7	-0.6	-0.6
Mg content in liver	0.8	0.9	0.9	0.9	0.9	-0.9	-0.9
Mn content in liver	1.2	1.3	1.7	1.0	1.0	-1.3	-1.3
Na content in liver	0.0	0.0	0.0	-0.1	-0.0	-0.1	-0.1
Rb content in liver	0.0	0.1	0.1	0.2	0.3	-0.2	-0.2
Se content in liver	5.3	6.3	6.5	2.6	2.6	-2.5	-2.5
Sr content in liver	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Zn content in liver	2.1	2.4	3.1	1.7	1.8	-1.4	-1.4
Bone: minimum diameter	0.4	0.8	0.9	0.9	0.9	-0.8	-0.8
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	0.4	-0.1	-0.3
Time in novel zone, hab. session 1	0.7	0.8	0.9	0.9	0.8	-1.0	-0.8
Total zone transitions, hab. session 1	0.0	0.0	0.1	0.2	0.2	-0.1	-0.1
Total locomotion distance, hab. session 1	0.3	0.5	0.5	-0.7	-0.7	0.7	0.6
Locomotion velocity, hab. session 1	1.0	1.5	1.7	-1.3	-1.3	1.2	1.1
Time in familiar zone, hab. session 2	0.4	0.5	0.6	0.8	0.8	-0.5	-0.7
Time in novel zone, hab. session 2	0.4	0.4	0.5	-0.7	-0.7	0.5	0.6
Total zone transitions, hab. session 2	0.5	0.6	0.7	0.8	0.8	-0.7	-0.8
Total locomotion distance, hab. session 2	0.4	0.5	0.7	-0.8	-0.8	0.7	0.5
Locomotion velocity, hab. session 2	0.2	0.3	0.3	-0.6	-0.5	0.5	0.5
Novel to familiar place preference ratio	0.5	0.7	0.8	0.9	0.9	-0.8	-0.7
Novelty place preference	0.4	0.5	0.7	0.8	0.8	-0.6	-0.6
Time in novel zone, NPP test	0.5	0.6	0.8	0.8	0.9	-0.7	-0.7
Total zone transitions, NPP test	0.1	0.1	0.2	0.4	0.4	-0.2	-0.3
Total locomotion distance, NPP test	0.0	0.0	0.1	0.2	0.2	-0.1	-0.1
Locomotion velocity, NPP test	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1
Intraocular pressure	0.1	0.2	0.3	-0.3	-0.3	0.4	0.5
Delta distance traveled before/after self-admin	0.9	1.0	1.4	-1.2	-1.2	0.9	0.8
Delta ambulatory time before/after self-admin	0.2	0.3	0.4	-0.6	-0.7	0.3	0.4
Parametrial fat weight	0.0	0.0	0.1	0.3	0.2	0.2	0.0
Pavlov. Cond. lever latency	0.6	0.7	0.9	-0.9	-0.9	0.8	0.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	0.6	0.6	-0.5	-0.6
Pavlov. Cond. change in total contacts	0.5	0.6	0.8	-0.7	-0.6	0.7	0.9
Pavlov. Cond. index score	0.4	0.5	0.6	0.7	0.7	-0.6	-0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	0.4	0.4	-0.3	-0.3
Pavlov. Cond. lever contacts	0.4	0.5	0.6	0.7	0.8	-0.6	-0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.2	-0.4	-0.4	0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.0	0.1	0.1	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	0.8	0.8	-0.7	-0.7
Pavlov. Cond. response bias	1.3	1.6	1.8	1.4	1.4	-1.2	-1.2
Pavlov. Cond. lever latency	0.1	0.2	0.2	-0.5	-0.5	0.3	0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Pavlov. Cond. change in total contacts	0.2	0.4	0.5	-0.6	-0.6	0.7	0.6
Pavlov. Cond. index score	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.2	-0.2	0.3	0.2
Pavlov. Cond. lever contacts	0.2	0.4	0.5	0.7	0.7	-0.4	-0.6
Pavlov. Cond. magazine entry number	0.3	0.4	0.4	0.6	0.6	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	0.1	0.1	-0.0	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.1	0.1	0.0	-0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	0.2	0.3	-0.1	-0.2
Time in closed arm before self-admin	0.7	1.3	1.6	1.1	1.0	-1.1	-1.3
Time in closed arm after self-admin	1.4	1.6	1.9	-1.4	-1.4	1.2	1.2
Time in open arm before self-admin	0.7	0.8	1.1	-0.8	-0.7	1.0	1.1
Time in open arm after self-admin	0.0	0.0	0.0	0.1	0.1	0.0	-0.0
Bone: periosteal estimation	0.4	0.9	1.1	1.0	1.0	-0.9	-0.9
Bone: periosteal perimeter	0.6	1.3	1.4	1.2	1.2	-1.1	-1.1
Bone: post-yield work	0.2	0.4	0.6	-0.8	-0.8	0.5	0.5
Progressive ratio test 1 active lever presses	2.5	4.4	4.6	2.1	2.1	-2.1	-2.1
Progressive ratio test 1 breakpoint	2.4	4.1	4.5	2.0	2.0	-2.0	-2.1
Progressive ratio test 1 inactive lever presses	1.2	3.2	3.5	1.8	1.9	-1.7	-1.7
Progressive ratio test 2 active lever presses	3.4	4.8	5.3	2.3	2.3	-2.1	-2.0
Progressive ratio test 2 breakpoint	4.1	5.2	5.6	2.4	2.4	-2.2	-2.1
Progressive ratio test 2 inactive lever presses	0.8	2.5	3.3	1.8	1.8	-1.4	-1.3
Incentive Sensitization - Responses	1.2	3.2	3.8	1.9	1.9	-1.7	-1.5
Incentive Sensitization - Breakpoint	1.4	3.1	3.7	1.9	1.9	-1.7	-1.5
Sum of active levers in priming session hrs 5-6	0.9	0.9	1.1	-1.0	-1.1	0.9	0.7
Progressive ratio	0.9	2.8	3.7	-1.6	-1.5	1.6	1.9
Food seeking constrained by brief footshock	3.0	3.8	4.1	-2.0	-1.9	2.0	1.8
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.2
Retroperitoneal fat weight	0.0	0.0	0.0	0.2	0.1	0.0	0.0
Reaction time number correct	1.3	4.5	4.8	2.1	2.1	-2.2	-2.2
Reaction time mean minus median	0.3	1.6	1.8	-1.3	-1.3	1.2	1.3
Reaction time mean minus median AUC	0.0	0.2	0.3	-0.5	-0.5	0.3	0.4
Reaction time num false alarms	4.8	8.1	8.4	2.9	2.9	-2.8	-2.8
Reaction time num false alarms AUC	3.2	7.4	7.8	2.8	2.8	-2.6	-2.6
Reaction time trials correct on left	1.3	4.5	4.8	2.1	2.1	-2.2	-2.2
Reaction time trials on left	1.3	4.6	4.9	2.1	2.1	-2.2	-2.2
Reaction time mean	1.4	3.2	3.3	-1.8	-1.8	1.8	1.8
Reaction time mean AUC	1.0	2.4	2.5	-1.6	-1.6	1.5	1.5
Median of all reaction times	1.6	2.6	2.7	-1.6	-1.6	1.6	1.6
Reaction time omissions	0.0	0.1	0.1	0.2	0.2	-0.3	-0.2
Reaction time false alarm rate	0.7	0.9	1.1	1.0	1.0	-0.9	-0.9
Reaction time premature initiation rate	0.2	0.3	0.4	-0.7	-0.6	0.5	0.5
Reaction time premature initiations	0.1	0.2	0.2	0.3	0.3	-0.5	-0.5
Std. dev. reaction times	0.5	1.6	1.8	-1.3	-1.3	1.2	1.2
Reaction time trials completed	1.3	4.6	4.9	2.1	2.1	-2.2	-2.2
Reaction time trials AUC	1.7	5.9	6.2	2.4	2.4	-2.5	-2.5
Run reversals in cocaine runway, females	0.7	0.7	1.3	-1.0	-1.1	0.5	0.7
Run reversals in cocaine runway, males	0.3	0.3	0.6	0.7	0.8	-0.2	-0.5
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.5	-0.5	0.1	0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.1	0.2	-0.4	-0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.5	-0.5	0.3	0.1
Std. dev. time between licks in bursts	0.1	0.2	0.3	0.4	0.4	-0.6	-0.6
Total sessions with >9 infusions	2.8	3.5	4.3	2.0	2.1	-1.8	-1.6
Short access day 1 total inactive lever presses	1.9	3.7	4.3	2.1	2.1	-1.7	-1.9
Short access day 10 total inactive lever presses	0.1	1.0	1.3	-1.0	-1.0	1.1	0.8
Short access day 1 total infusions	1.2	2.4	2.9	1.6	1.7	-1.5	-1.3
Short access day 10 total infusions	2.8	4.7	5.9	2.4	2.4	-2.0	-1.8
Short access total infusions	2.1	3.0	3.4	1.8	1.8	-1.7	-1.5
Short access day 1 locomotion	2.8	4.6	5.1	2.2	2.3	-2.1	-2.0
Short access day 10 total locomotion	0.0	0.1	0.3	-0.1	-0.1	0.4	0.5
Short access total locomotion	0.5	0.8	1.3	1.1	1.1	-0.6	-0.5
One hour access (0.3 mA shock)	0.1	0.2	0.2	0.4	0.4	-0.4	-0.5
Compulsive drug intake	0.1	0.1	0.2	0.4	0.4	-0.0	-0.2
One hour access (shock baseline)	0.5	1.4	1.6	1.0	1.1	-1.3	-1.3
Social response proportion	0.5	0.7	0.8	0.8	0.7	-0.8	-0.9
Social responses	0.7	1.0	1.1	1.0	1.0	-0.9	-0.9
Social time	2.5	3.9	3.9	-2.0	-2.0	2.0	2.0
Soleus weight	0.2	0.5	0.7	0.8	0.8	-0.6	-0.5
Bone: stiffness	0.9	1.5	1.7	1.2	1.2	-1.3	-1.2
Tibialis anterior weight	4.5	15.5	16.6	4.1	4.1	-3.8	-3.8
Time to tail flick, vehicle, before self-admin	1.7	2.1	2.6	1.4	1.4	-1.6	-1.4
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.4	-0.7	-0.7	0.6	0.4
Time to tail flick, test, before self-admin	0.6	0.6	1.0	-1.0	-1.0	0.5	0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	-0.6	-0.6	0.8	0.6
Delta time to tail flick, test, before/after SA	1.1	1.4	1.9	1.4	1.4	-1.0	-0.9
Tibia length	0.4	1.0	1.3	1.2	1.1	-0.9	-0.9
Ambulatory time before self-admin	0.0	0.0	0.0	-0.1	-0.1	0.2	0.1
Ambulatory time after self-admin	0.8	1.3	1.6	-1.3	-1.3	1.1	1.0
Bone: tissue strength	0.4	0.4	0.5	-0.7	-0.7	0.6	0.4
Total heroin consumption	0.0	0.1	0.1	0.2	0.1	-0.2	-0.4
Bone: trabecular number	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.1
Bone: trabecular spacing	0.0	0.0	0.0	0.1	0.1	0.0	-0.1
Bone: trabecular thickness	1.2	1.6	2.1	1.4	1.4	-1.1	-1.1
Bone: trabecular tissue density	0.1	0.1	0.2	0.4	0.4	-0.1	-0.3
Water consumed over 24 hours	0.3	0.7	0.7	-0.9	-0.8	0.8	0.8
Number of responses in last shaping day	1.7	2.2	2.5	1.6	1.6	-1.3	-1.4