Cert1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Cert1	0.05	0.03	9.5e-03	0.02	0.03	-0	0.02	5.6e-02	1.9e-02	5.2e-01	5.5e-02
2	LHb	gene expression	Cert1	0.14	0.11	7.1e-03	0	0.04	-0.01	0	2.5e-01	3.5e-02	9.0e-01	2.5e-01
3	pVTA	gene expression	Cert1	0.04	0.03	2.0e-04	0.06	0.05	0.04	0.05	3.0e-05	4.4e-05	2.4e-04	7.1e-05
4	IL	gene expression	Cert1	0.4	0.3	6.8e-05	0.15	0.06	0.14	0.02	1.6e-04	1.4e-02	3.0e-04	9.9e-02
5	Brain	mRNA stability	Cert1	0.16	0.12	7.6e-05	0.06	0.04	0.04	0.05	2.1e-06	1.7e-04	1.1e-04	2.4e-05
6	pVTA	mRNA stability	Cert1	0.07	0.07	8.9e-03	0.04	0.01	0.04	0.02	6.5e-04	6.6e-02	7.2e-04	9.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.4	0.6	2.4	0.7	-0.7	-0.5	0.5	-0.3	-1.5
Area under the delay curve	1.6	1.9	4.4	-1.4	1.4	1.1	-0.8	-1.1	2.1
BMI with tail	1.6	5.6	7.5	-2.7	2.7	2.4	-2.3	0.8	2.6
BMI without tail	1.3	4.1	5.3	-2.3	2.3	2.0	-2.0	2.1	1.2
Body weight	1.9	8.1	11.6	-3.4	3.3	3.1	-3.0	2.1	1.8
Weight adjusted by age	0.0	0.0	0.1	0.3	-0.3	0.1	0.1	0.0	0.0
Bone surface	0.0	0.0	0.2	0.0	-0.0	-0.1	0.0	-0.4	-0.2
Bone volume	0.4	0.8	1.0	0.9	-0.9	-0.8	0.7	-1.0	-1.0
Breakpoint value in progressive ratio session	0.4	0.5	1.6	0.6	-0.4	-0.5	0.5	-1.3	0.4
Number of licking bursts	0.0	0.1	0.2	-0.3	0.2	0.1	-0.2	0.4	0.3
Context. condit. distance diff. score	1.2	1.4	2.8	1.2	-1.2	-1.5	1.7	-0.2	-0.8
Locomotion velocity, session 1	0.5	0.6	0.8	0.9	-0.9	-0.9	0.3	0.5	-0.8
Locomotion distance, session 1	0.9	1.2	2.0	1.3	-1.3	-0.9	0.7	0.3	-1.4
Locomotion velocity, session 2	0.4	0.5	1.6	0.7	-0.6	-0.4	0.3	0.1	-1.3
Locomotion distance, session 2	1.2	1.7	2.5	1.6	-1.6	-1.3	1.1	0.1	-1.6
Locomotion velocity, session 3	1.5	1.8	3.4	1.5	-1.5	-1.3	1.8	-1.0	-0.4
Locomotion distance, session 3	1.2	1.3	2.7	0.9	-0.9	-1.1	1.6	-1.2	0.8
Stereotopy head waving bouts, day 3	1.4	1.6	2.6	1.5	-1.5	-1.6	1.2	0.4	-1.0
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.2	-0.2	-0.2	-0.4	0.6	-0.2
Locomotion velocity, session 7	0.9	0.9	2.4	0.6	-0.6	-1.0	1.1	-1.5	0.4
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	0.3	-0.1	0.1	-0.4	0.3
Stereotopy head waving bouts, day 7	2.4	2.8	4.9	1.7	-1.8	-1.9	2.2	0.3	-1.3
Stereotopy head waving duration, day 7	0.8	0.9	1.6	1.1	-1.1	-0.9	1.3	0.2	-0.8
Locomotion velocity, session 8	4.2	5.1	9.5	2.4	-2.4	-2.3	2.0	0.5	-3.1
Locomotion distance, session 8	1.5	2.1	3.1	1.4	-1.5	-1.5	1.7	0.4	-1.7
Degree of sensitization distance	0.9	0.9	2.0	-0.9	0.9	0.9	-1.4	0.9	-0.7
Degree of sensitization stereotypy	1.9	2.1	4.8	1.5	-1.5	-1.6	2.2	-0.3	-0.7
Conditioned locomotion	0.1	0.1	0.3	-0.1	0.0	-0.0	0.4	-0.3	0.6
Cocaine response after cond. corrected	0.1	0.2	0.7	-0.2	0.2	0.4	-0.0	-0.3	0.8
Cocaine response after cond. not corrected	0.3	0.3	0.6	-0.7	0.7	0.8	-0.4	0.3	0.5
Cocaine response before conditioning	0.2	0.2	0.6	-0.4	0.3	0.1	-0.0	0.8	-0.7
Saline control response	0.8	1.0	2.3	-1.1	1.0	0.9	-1.0	1.5	-0.2
Bone: connectivity density	0.2	0.3	1.2	0.3	-0.3	-0.3	0.3	0.1	-1.1
Bone: cortical apparent density	2.8	3.8	7.3	1.9	-1.9	-2.1	2.7	-1.9	-0.5
Bone: cortical area	0.3	0.4	1.8	0.3	-0.3	-0.1	0.3	-1.3	0.6
Bone: cortical porosity	0.2	0.2	1.2	-0.0	0.0	0.2	0.1	-0.5	1.1
Bone: cortical porosity	0.3	0.3	1.0	0.2	-0.2	-0.1	0.5	-0.6	1.0
Bone: cortical thickness	0.8	1.3	3.1	1.1	-1.1	-0.6	1.3	-1.8	0.4
Bone: cortical thickness	1.0	1.2	2.2	-1.1	1.1	1.3	-0.8	-0.2	1.5
Bone: cortical tissue density	2.8	3.8	7.1	1.9	-1.9	-2.1	2.7	-1.9	-0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	2.8	0.2	-0.3	0.3	0.4	0.7	-1.7
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.5	0.1	-0.1	0.5	0.3	1.0	-1.2
Condit. Reinf. active responses	0.4	0.5	2.5	-0.1	-0.0	0.6	0.1	0.5	-1.6
Condit. Reinf. inactive responses	0.2	0.2	0.7	-0.3	0.2	0.4	-0.4	-0.2	-0.8
Incentive salience index mean	0.5	0.6	1.6	-0.4	0.4	1.0	-0.3	0.8	-1.3
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.3	0.2	0.5	-0.1	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	-0.4	0.4	0.2	-0.1	-0.9	0.7
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.7	-0.8	0.8	0.8	-0.7	0.0	0.4
Condit. Reinf. active responses	0.2	0.3	1.4	0.0	-0.0	-0.2	0.2	-1.2	0.4
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.3	0.3	0.2	-0.4	-0.2	-0.0
Condit. Reinf. lever presses	0.3	0.4	2.1	-0.3	0.3	0.0	0.1	-1.5	0.5
Condit. Reinf. lever reinforcers received	0.3	0.4	1.9	-0.1	0.2	-0.1	0.1	-1.4	0.8
Conditioned reinforcement - actives	0.9	1.5	4.2	-0.6	0.5	0.3	-0.7	2.0	-1.8
Conditioned reinforcement - inactives	0.0	0.1	0.1	-0.2	0.1	-0.3	0.3	0.3	0.2
Conditioned locomotion	1.2	1.6	4.6	0.8	-0.9	-1.2	1.1	0.7	-2.1
Patch foraging indifference point 0 sec	0.5	1.0	1.9	-1.4	1.3	0.9	-0.8	0.5	0.8
Patch foraging indifference point AUC	1.0	1.4	2.0	-1.3	1.3	1.3	-1.2	0.0	1.4
Delay disc. indifference point, 0s delay	1.1	1.2	3.8	-0.3	0.3	0.1	0.0	-1.8	1.9
Delay disc. indifference point, 16s delay	0.4	0.5	1.0	-0.8	0.8	0.6	-0.3	-0.1	1.0
Delay disc. indifference point, 2s delay	1.3	1.4	4.0	-0.7	0.7	0.5	-0.2	-1.8	2.0
Delay disc. indifference point, 24s delay	2.7	3.0	4.2	-2.0	2.0	1.6	-1.6	-0.8	2.1
Delay disc. indifference point, 4s delay	0.7	0.7	2.3	-0.4	0.4	0.4	-0.2	-1.2	1.5
Delay disc. indifference point, 8s delay	1.8	2.2	2.7	-1.6	1.7	1.7	-1.5	-0.4	1.6
Indifference point function ln k	0.3	0.6	1.8	0.5	-0.5	-0.4	0.5	0.8	-1.4
Indifference point function log k	0.3	0.6	1.8	0.5	-0.5	-0.4	0.5	0.8	-1.4
Patch foraging total patch changes 0 sec	0.5	1.0	1.8	-1.4	1.3	0.9	-0.8	0.5	0.9
Patch foraging total patch changes 12 sec	1.5	1.9	2.7	-1.6	1.6	1.5	-1.5	0.1	1.3
Patch foraging total patch changes 18 sec	1.2	1.8	3.1	-1.7	1.7	1.0	-1.0	-0.5	1.8
Patch foraging total patch changes 24 sec	2.0	3.5	6.1	-2.5	2.4	1.7	-1.4	0.9	1.9
Patch foraging total patch changes 6 sec	1.0	1.5	2.2	-1.4	1.4	1.5	-1.3	-0.3	1.2
Patch foraging time to switch 0 sec	0.2	0.5	1.8	0.2	-0.0	0.1	-0.2	-1.3	0.9
Patch foraging water rate 0 sec	0.1	0.3	1.4	-0.2	0.0	0.0	0.3	1.2	-0.5
Patch foraging water rate 12 sec	0.5	1.1	2.9	0.6	-0.8	-1.4	1.7	0.5	-0.9
Patch foraging water rate 18 sec	0.8	1.2	3.1	-1.3	1.1	1.1	-0.3	1.8	-0.4
Patch foraging water rate 24 sec	0.6	0.9	1.4	-1.1	1.0	0.9	-0.8	1.2	-0.2
Patch foraging water rate 6 sec	0.6	0.9	2.0	0.4	-0.6	-1.2	1.4	0.5	-1.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.4	-0.3	0.1	0.7	-0.4	1.1	-1.2
Distance traveled before self-admin	0.4	0.6	1.3	-0.7	0.7	0.7	-0.6	-0.6	1.1
Distance traveled after self-admin	1.9	2.3	3.9	-1.7	1.7	2.0	-1.8	0.6	1.0
Extensor digitorum longus weight	0.1	0.2	0.7	0.2	-0.1	-0.0	-0.7	-0.8	0.1
Bone: elastic displacement	1.3	1.6	3.4	1.0	-0.9	-1.5	1.1	-1.9	0.8
Bone: elastic work	0.4	0.5	1.1	0.7	-0.7	-0.8	0.6	-1.0	-0.1
Bone: endosteal estimation	0.4	0.8	1.7	-1.0	1.0	0.8	-1.3	0.4	0.6
Bone: endosteal perimeter	0.1	0.3	0.7	-0.6	0.6	0.3	-0.8	0.1	0.3
Epididymis fat weight	1.8	6.2	11.6	-2.5	2.4	2.8	-2.3	3.4	0.2
Delta time in closed arm before/after self-admin	1.0	1.0	1.7	0.6	-0.6	-1.0	1.0	-1.2	1.3
Delta time in open arm before/after self-admin	0.3	0.3	1.0	-0.5	0.5	1.0	-0.6	-0.1	0.2
Diff in mean of infusions in LGA sessions	0.6	0.8	1.2	0.8	-0.8	-1.1	1.0	-1.0	-0.5
Delay discount exponential model param	1.6	1.8	4.0	1.4	-1.4	-1.1	0.8	1.0	-2.0
Extinction: sum of active levers before priming	0.2	0.3	1.0	-0.2	0.2	-0.2	0.5	-0.4	1.0
Active lever presses in extinction session 6	0.2	0.2	0.6	0.1	-0.1	-0.5	0.4	-0.8	0.5
Bone: final force	0.4	0.7	2.3	-0.2	0.3	0.4	-0.5	-1.5	1.0
Bone: final moment	0.5	0.8	2.5	-0.2	0.3	0.4	-0.5	-1.6	1.2
Food consumed during 24 hour testing period	1.2	1.7	3.1	-1.4	1.4	1.8	-1.1	-0.4	1.4
Glucose	1.3	2.0	2.6	1.5	-1.5	-1.4	1.5	-1.0	-1.6
Heart weight	1.0	1.5	2.8	-1.3	1.4	1.1	-1.2	1.7	0.0
Delay discount hyperbolic model param	1.4	1.5	3.4	1.3	-1.3	-1.0	0.7	1.0	-1.9
Intermittent access intake day 1-15 change	0.0	0.1	0.2	0.2	-0.2	-0.5	0.2	0.0	0.3
Intermittent access intake escalation	0.0	0.1	0.2	0.2	-0.2	-0.4	0.3	-0.1	0.4
Intermittent access intake escalation 2	0.1	0.1	0.3	0.2	-0.2	-0.2	0.1	-0.1	0.6
Intermitt. access day 1 inactive lever presses	0.7	2.6	4.6	1.5	-1.5	-1.5	2.2	-1.9	0.4
Intermitt. access day 15 inactive lever presses	1.3	2.7	4.2	1.1	-1.1	-1.7	2.0	-1.9	1.7
Intermitt. access escalation Index	0.1	0.2	0.6	0.4	-0.4	0.2	0.0	-0.8	0.6
Intermittent access day 1 total infusions	2.1	3.3	6.4	-2.5	2.4	1.5	-1.3	1.7	1.0
Intermittent access day 15 total infusions	0.5	0.7	1.4	-1.2	1.1	0.5	-0.4	0.8	0.8
Intermittent access terminal intake (last 3 days)	0.4	0.5	1.1	-0.9	0.8	0.3	-0.3	1.0	0.5
Intermittent access total infusions	1.0	1.2	2.7	-1.7	1.5	0.7	-0.7	1.0	0.7
Intermittent access day 1 locomotion	0.7	0.9	1.9	-1.4	1.3	0.9	-0.8	0.5	0.1
Intermittent access day 15 total locomotion	0.9	1.7	3.4	-1.8	1.7	1.1	-0.9	1.3	0.2
Intermittent access total locomotion	0.3	0.4	1.2	-1.1	1.0	0.3	-0.2	0.1	0.2
Intermittent access standard deviation	0.1	0.2	1.0	-0.1	0.1	-0.0	0.2	-0.2	1.0
Left kidney weight	3.9	18.2	25.1	-5.0	4.9	4.8	-4.4	3.8	2.0
Right kidney weight	4.3	19.5	27.2	-5.2	5.2	5.0	-4.6	3.3	2.5
Cocaine induced anxiety	0.5	0.8	1.6	1.3	-1.1	-0.6	0.4	-0.3	-1.0
Post-drug Anxiety	0.6	0.7	2.5	0.8	-0.7	-0.2	0.2	0.5	-1.6
Baseline Anxiety	0.2	0.2	0.5	-0.7	0.6	0.2	-0.1	0.6	-0.3
Tail length	0.7	2.7	6.1	-1.5	1.4	1.6	-1.7	2.5	-0.7
Length with tail	1.0	4.4	8.4	-2.1	2.0	2.1	-2.3	2.9	-0.5
Length without tail	1.0	3.2	4.3	-2.1	2.0	2.1	-2.0	1.4	0.7
Times rat made contact with spout	2.0	2.2	4.1	-1.7	1.6	2.0	-1.2	1.6	-0.2
Lifetime Intake	1.0	1.2	2.6	-1.6	1.5	0.6	-0.6	1.0	0.7
Liver weight, left	4.8	7.9	11.5	-3.4	3.3	2.9	-2.9	1.5	2.4
Liver weight, right	1.7	3.0	4.7	-2.2	2.0	1.7	-1.8	1.2	1.0
Locomotor activity	0.0	0.0	0.1	0.2	-0.1	0.1	0.2	-0.0	-0.1
Locomotor testing distance	0.4	0.6	1.1	-0.9	1.0	1.0	-0.7	0.3	0.7
Locomotor testing rearing	0.1	0.2	0.6	-0.4	0.6	0.4	-0.2	-0.1	0.8
Locomotion in novel chamber	0.7	0.9	1.8	1.0	-1.0	-1.0	1.3	0.2	-0.9
Locomotion in novel chamber post-restriction	0.2	0.4	1.7	0.1	-0.2	-0.2	0.1	0.7	-1.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.4	-0.1	0.1	0.0	-0.5	0.7	0.4
Change in fecal boli incidents, locomotor task	1.0	1.0	2.8	0.8	-0.9	-0.9	0.9	0.2	-1.7
Time >=10cm from walls, locomotor time 1	1.9	2.0	4.4	1.3	-1.4	-1.1	1.2	1.2	-2.1
Bouts of movement, locomotor time 1	0.7	0.8	2.1	0.2	0.1	0.9	-0.9	-1.4	0.9
Total resting periods, locomotor time 1	0.4	0.5	1.3	0.2	0.0	1.0	-1.1	-0.8	0.0
Rest time, locomotor task time 1	1.3	1.6	4.9	1.4	-1.3	-0.9	0.3	0.7	-2.2
Distance moved, locomotor task time 1	0.8	1.1	2.6	-1.6	1.5	0.8	-0.3	-0.0	1.2
Vertical activity count, locomotor time 1	0.3	0.8	2.0	-1.4	1.2	0.4	-0.0	0.2	1.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	0.2	-0.3	-0.2	0.6	-0.0	-0.3
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.5	-0.5	-0.0	0.5	-0.3	-0.2
Total resting periods, locomotor time 2	0.1	0.2	0.4	0.6	-0.5	-0.1	0.6	-0.4	-0.1
Rest time, locomotor task time 2	0.3	0.4	0.7	0.6	-0.6	-0.6	0.3	0.6	-0.8
Distance moved, locomotor task time 2	0.4	0.5	1.0	-1.0	0.9	0.8	-0.1	-0.2	0.5
Vertical activity count, locomotor time 2	0.3	0.4	0.9	-1.0	0.8	0.3	0.2	0.1	0.8
Light reinforcement 1	0.7	1.7	2.6	-0.7	0.8	1.6	-1.6	1.6	-1.1
Light reinforcement 2	0.5	0.8	1.5	-0.7	0.6	1.2	-1.1	1.2	-0.4
Bone: marrow area	0.4	0.8	1.8	-1.0	1.0	0.8	-1.3	0.3	0.7
Bone: maximum diameter	0.7	1.3	2.2	-1.1	1.2	1.0	-1.1	-0.7	1.5
Bone: maximum force	0.3	0.5	0.9	-0.5	0.5	0.6	-0.7	-0.8	0.9
Bone: maximum moment	0.3	0.6	1.2	-0.5	0.6	0.6	-0.8	-0.9	1.1
Mean time between licks in bursts	0.6	1.4	2.0	-1.4	1.4	1.3	-1.3	0.7	0.8
Mean num. licks in bursts	0.3	0.5	1.4	-0.7	0.8	1.2	-0.5	0.1	-0.0
Cd content in liver	0.3	0.4	1.2	-0.0	0.1	-0.2	0.1	-1.0	1.1
Co content in liver	0.5	0.5	2.1	-0.1	0.1	0.4	-0.2	0.9	-1.4
Cu content in liver	0.4	0.5	1.4	0.4	-0.5	-0.7	0.4	0.7	-1.2
Fe content in liver	0.9	1.1	1.7	1.0	-1.0	-1.3	1.0	-1.3	0.6
K content in liver	0.5	0.5	0.8	-0.9	0.9	0.8	-0.8	0.1	0.6
Mg content in liver	0.1	0.1	0.2	0.1	-0.2	-0.4	0.5	-0.0	0.0
Mn content in liver	2.2	2.5	3.2	1.7	-1.7	-1.7	1.8	-1.7	0.3
Na content in liver	0.8	0.9	2.6	-0.8	0.7	0.7	-0.9	1.6	-0.6
Rb content in liver	0.3	0.4	0.6	-0.8	0.7	0.7	-0.3	0.7	-0.1
Se content in liver	1.6	1.8	2.8	1.5	-1.6	-1.6	1.7	-0.8	-0.3
Sr content in liver	0.2	0.2	0.5	0.4	-0.3	0.1	-0.7	-0.5	0.1
Zn content in liver	0.4	0.4	1.2	0.1	-0.2	-0.3	0.3	1.1	-1.0
Bone: minimum diameter	0.7	1.2	1.9	1.4	-1.4	-1.1	1.1	-0.9	-0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.2	0.2	-0.0	0.2	0.4	-0.4
Time in novel zone, hab. session 1	0.9	0.9	1.3	-0.9	1.0	1.1	-1.1	0.2	1.1
Total zone transitions, hab. session 1	0.7	1.0	1.6	1.1	-1.1	-0.9	1.0	-0.1	-1.3
Total locomotion distance, hab. session 1	0.5	0.7	1.0	0.9	-1.0	-0.8	0.8	-0.4	-0.9
Locomotion velocity, hab. session 1	1.0	1.4	2.0	1.4	-1.4	-1.2	1.0	-0.4	-1.4
Time in familiar zone, hab. session 2	1.3	1.4	2.3	-1.5	1.4	1.2	-0.8	1.3	0.5
Time in novel zone, hab. session 2	0.4	0.4	1.2	0.7	-0.6	-0.7	0.4	-1.1	0.2
Total zone transitions, hab. session 2	0.2	0.2	0.7	-0.0	0.0	0.1	-0.3	0.7	-0.8
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.5	-0.5	-0.5	0.3	0.1	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.2	0.4	-0.4	-0.4	0.2	-0.1	-0.2
Novel to familiar place preference ratio	0.3	0.3	0.5	0.6	-0.6	-0.7	0.7	-0.4	0.5
Novelty place preference	0.3	0.3	0.6	0.6	-0.5	-0.7	0.8	-0.3	0.5
Time in novel zone, NPP test	0.5	0.6	1.0	0.8	-0.8	-1.0	1.0	-0.3	0.3
Total zone transitions, NPP test	0.5	0.7	1.0	1.0	-1.0	-0.9	0.6	-0.5	-1.0
Total locomotion distance, NPP test	1.6	2.2	3.2	1.6	-1.6	-1.8	1.4	-0.6	-1.5
Locomotion velocity, NPP test	1.0	1.4	2.0	1.3	-1.3	-1.4	1.1	-0.7	-1.1
Intraocular pressure	5.6	8.1	11.1	3.3	-3.3	-3.0	3.1	-0.8	-2.6
Delta distance traveled before/after self-admin	1.1	1.2	1.7	-1.2	1.2	1.3	-1.2	0.8	0.6
Delta ambulatory time before/after self-admin	1.0	1.2	1.7	-1.3	1.3	1.2	-1.2	1.0	0.2
Parametrial fat weight	0.1	0.2	0.6	-0.3	0.2	0.2	-0.2	0.8	-0.5
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.6	-0.6	-0.8	0.5	-0.4	-0.2
Pavlov. Cond. magazine entry latency	1.7	2.2	4.5	-1.3	1.3	1.4	-1.7	2.1	-0.9
Pavlov. Cond. change in total contacts	0.5	0.5	1.0	-0.4	0.4	0.6	-0.7	0.9	-1.0
Pavlov. Cond. index score	1.0	1.2	1.6	-1.2	1.1	1.2	-1.3	1.2	-0.2
Pavlov. Cond. latency score	0.9	1.1	1.6	-1.1	1.0	1.2	-1.2	1.3	-0.2
Pavlov. Cond. lever contacts	0.0	0.1	0.1	-0.1	0.1	0.2	-0.0	0.4	-0.3
Pavlov. Cond. magazine entry number	3.2	4.0	5.9	2.0	-2.0	-2.2	2.4	-2.3	0.3
Pavlov. Cond. intertrial magazine entries	1.1	1.4	4.4	1.0	-1.1	-0.4	0.7	0.9	-2.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	0.9	-0.9	0.8	0.9	-1.0	0.9	-0.3
Pavlov. Cond. response bias	1.4	1.7	2.2	-1.4	1.3	1.5	-1.5	1.5	-0.3
Pavlov. Cond. lever latency	0.6	0.8	3.8	0.2	-0.3	-0.2	-0.2	1.9	-1.0
Pavlov. Cond. magazine entry latency	3.7	4.5	6.2	-2.4	2.5	2.1	-2.1	-0.6	2.4
Pavlov. Cond. change in total contacts	0.7	1.1	4.3	-0.6	0.7	0.5	-0.4	-2.1	1.1
Pavlov. Cond. index score	1.7	2.3	3.6	-1.4	1.5	1.3	-1.1	-1.8	1.9
Pavlov. Cond. latency score	2.1	2.8	4.4	-1.6	1.7	1.4	-1.2	-1.8	2.1
Pavlov. Cond. lever contacts	0.7	1.0	4.7	-0.2	0.3	0.2	0.2	-2.2	1.1
Pavlov. Cond. magazine entry number	3.4	4.2	5.3	2.2	-2.3	-2.1	1.9	1.2	-2.3
Pavlov. Cond. intertrial magazine entries	0.3	0.5	0.8	0.9	-0.9	-0.7	0.5	0.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.6	3.9	-1.5	1.6	1.4	-1.1	-1.8	2.0
Pavlov. Cond. response bias	0.8	1.1	3.7	-0.6	0.7	0.7	-0.4	-1.9	1.3
Time in closed arm before self-admin	0.8	1.0	3.0	0.8	-0.9	-0.9	0.8	0.6	-1.7
Time in closed arm after self-admin	0.7	0.8	1.5	0.7	-0.7	-1.2	1.2	-0.8	0.0
Time in open arm before self-admin	2.0	2.2	3.5	-1.6	1.6	1.7	-1.9	1.4	0.2
Time in open arm after self-admin	2.1	2.3	4.3	-1.4	1.5	2.1	-1.9	0.9	0.5
Bone: periosteal estimation	0.2	0.5	1.4	-0.4	0.4	0.4	-0.6	-0.9	1.2
Bone: periosteal perimeter	0.2	0.3	0.6	-0.4	0.4	0.2	-0.5	-0.6	0.8
Bone: post-yield work	0.1	0.2	0.5	-0.5	0.5	0.3	-0.7	0.6	0.0
Progressive ratio test 1 active lever presses	0.7	0.9	1.9	-1.4	1.3	0.4	-0.6	0.4	1.1
Progressive ratio test 1 breakpoint	0.7	0.8	1.8	-1.3	1.2	0.4	-0.6	0.4	1.0
Progressive ratio test 1 inactive lever presses	0.2	0.4	1.0	-0.6	0.5	-0.6	0.4	-0.1	1.0
Progressive ratio test 2 active lever presses	2.1	2.5	4.1	-2.0	1.9	1.4	-1.5	1.5	0.7
Progressive ratio test 2 breakpoint	2.1	2.4	3.9	-2.0	1.9	1.4	-1.4	1.6	0.6
Progressive ratio test 2 inactive lever presses	0.4	0.7	2.4	-0.9	0.8	0.3	-0.4	1.5	-0.2
Incentive Sensitization - Responses	2.0	2.8	3.5	-1.8	1.8	1.9	-1.9	1.8	0.2
Incentive Sensitization - Breakpoint	2.0	2.6	3.5	-1.8	1.7	1.7	-1.8	1.9	0.1
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.7	0.5	-0.4	-0.3	0.1	-1.3	0.5
Progressive ratio	0.1	0.2	0.6	-0.3	0.3	0.8	-0.4	-0.2	-0.0
Food seeking constrained by brief footshock	0.4	0.5	1.1	-0.7	0.7	0.9	-1.1	0.2	-0.1
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.3	0.1	0.0
Retroperitoneal fat weight	0.8	3.3	8.2	-1.9	1.8	1.7	-1.4	2.9	0.2
Reaction time number correct	0.8	1.4	3.2	1.0	-1.0	-1.3	1.8	-1.0	-0.9
Reaction time mean minus median	0.1	0.3	1.2	0.0	0.0	-0.2	0.1	-1.1	0.5
Reaction time mean minus median AUC	0.1	0.2	0.3	-0.5	0.5	0.2	-0.3	-0.4	0.4
Reaction time num false alarms	0.7	1.0	3.0	-1.1	0.9	0.5	-0.6	1.7	-0.4
Reaction time num false alarms AUC	0.9	1.5	4.2	-1.4	1.2	0.8	-0.8	2.0	-0.3
Reaction time trials correct on left	0.8	1.4	3.2	1.0	-1.0	-1.3	1.8	-1.0	-0.9
Reaction time trials on left	0.9	1.7	3.9	1.1	-1.1	-1.4	2.0	-1.1	-0.9
Reaction time mean	0.5	0.8	1.3	0.7	-0.7	-1.0	1.1	-1.1	0.1
Reaction time mean AUC	0.3	0.5	0.9	0.6	-0.6	-0.8	0.9	-1.0	0.3
Median of all reaction times	0.4	0.5	0.9	0.7	-0.6	-0.9	1.0	-0.8	-0.0
Reaction time omissions	2.1	3.1	6.0	1.3	-1.3	-1.8	2.4	-2.4	-0.1
Reaction time false alarm rate	1.9	2.7	5.7	-1.7	1.6	1.4	-1.7	2.4	0.1
Reaction time premature initiation rate	2.0	2.7	3.9	-1.6	1.7	1.9	-1.8	2.0	0.1
Reaction time premature initiations	0.3	0.6	1.0	-0.8	0.8	0.8	-0.4	1.0	-0.4
Std. dev. reaction times	0.3	0.5	1.3	0.5	-0.5	-0.8	0.9	-1.1	0.2
Reaction time trials completed	0.9	1.7	3.9	1.1	-1.1	-1.4	2.0	-1.1	-0.9
Reaction time trials AUC	0.9	1.7	3.6	1.0	-1.1	-1.3	1.9	-1.2	-0.9
Run reversals in cocaine runway, females	0.9	0.9	3.5	0.2	-0.3	-0.2	-0.1	1.4	-1.9
Run reversals in cocaine runway, males	0.5	0.5	1.1	0.3	-0.3	-0.7	0.6	-0.8	1.0
Latency to leave start box in cocaine runway	0.3	0.3	0.9	0.2	-0.2	-0.3	0.4	-0.9	0.7
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.0	-0.0	0.1	-0.0	-0.3	-0.2
Latency to leave start box in cocaine runway, M	0.5	0.5	1.2	0.4	-0.3	-0.3	0.5	-1.0	1.1
Std. dev. time between licks in bursts	1.4	1.9	2.7	-1.7	1.6	1.4	-1.6	1.1	0.5
Total sessions with >9 infusions	0.5	0.6	1.3	-1.2	1.0	0.1	-0.1	1.0	0.6
Short access day 1 total inactive lever presses	0.2	0.2	0.5	-0.7	0.7	0.3	-0.3	-0.4	0.4
Short access day 10 total inactive lever presses	0.6	1.4	1.9	1.4	-1.3	-0.9	1.3	-1.1	-0.8
Short access day 1 total infusions	0.3	0.3	0.7	-0.8	0.7	0.2	-0.4	0.6	0.4
Short access day 10 total infusions	0.5	0.7	1.7	-1.0	0.9	-0.4	0.4	-0.3	1.3
Short access total infusions	0.6	0.7	1.8	-1.3	1.2	0.2	-0.4	0.6	0.8
Short access day 1 locomotion	0.1	0.2	0.3	-0.4	0.3	-0.6	0.5	0.4	0.1
Short access day 10 total locomotion	1.8	3.4	6.3	1.4	-1.6	-2.1	2.5	-2.2	0.4
Short access total locomotion	0.7	0.9	2.5	0.3	-0.5	-1.4	1.6	-0.4	-0.0
One hour access (0.3 mA shock)	0.4	0.5	0.9	-1.0	0.9	0.2	-0.5	0.9	0.3
Compulsive drug intake	0.2	0.2	0.3	-0.6	0.5	0.4	-0.6	0.2	-0.3
One hour access (shock baseline)	0.2	0.2	0.9	-0.5	0.5	0.0	-0.1	0.1	1.0
Social response proportion	4.7	5.4	7.9	2.8	-2.8	-2.4	2.5	-1.7	-1.4
Social responses	1.6	2.0	2.8	1.6	-1.7	-1.3	1.5	-0.2	-1.6
Social time	1.5	2.1	3.8	1.8	-1.7	-1.0	0.9	-1.9	-0.9
Soleus weight	0.2	0.5	1.3	-0.4	0.4	0.3	-1.1	1.1	-0.6
Bone: stiffness	0.3	0.5	1.0	-0.6	0.6	1.0	-0.8	-0.1	0.5
Tibialis anterior weight	2.3	7.9	11.7	3.4	-3.4	-3.2	2.7	-1.3	-2.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	-0.7	0.6	0.1	-0.2	-0.2	0.1
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.5	-1.0	1.0	0.9	-0.8	0.1	1.2
Time to tail flick, test, before self-admin	2.3	2.4	7.4	-0.2	0.2	-0.2	0.6	-2.5	2.7
Time to tail flick, test, after self-admin	1.4	1.5	4.5	1.4	-1.4	-0.3	0.4	0.5	-2.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.7	0.1	-0.0	0.2	-0.3	-0.2	0.8
Delta time to tail flick, test, before/after SA	3.5	3.6	13.6	1.5	-1.5	-0.4	0.1	1.8	-3.7
Tibia length	0.3	0.8	1.5	-1.0	1.0	1.2	-0.9	0.6	0.0
Ambulatory time before self-admin	0.6	0.9	1.9	-0.8	0.9	1.0	-0.9	-0.5	1.4
Ambulatory time after self-admin	1.6	1.8	2.9	-1.5	1.5	1.7	-1.5	-0.0	1.2
Bone: tissue strength	0.1	0.1	0.2	0.1	-0.0	0.3	-0.3	0.0	-0.4
Total heroin consumption	0.4	0.5	1.6	0.8	-0.7	-0.4	0.4	-1.3	-0.3
Bone: trabecular number	0.2	0.3	1.6	0.1	-0.1	0.1	-0.1	0.2	-1.3
Bone: trabecular spacing	1.0	1.3	5.3	0.1	-0.1	-0.5	0.6	-1.3	2.3
Bone: trabecular thickness	2.2	2.7	4.1	2.0	-2.0	-1.6	1.3	-0.6	-1.9
Bone: trabecular tissue density	0.3	0.5	0.6	0.7	-0.7	-0.7	0.6	-0.8	0.5
Water consumed over 24 hours	1.7	2.3	4.6	-1.7	1.7	2.2	-1.4	0.9	0.7
Number of responses in last shaping day	0.8	0.9	3.9	-0.7	0.7	-0.2	0.1	-0.7	2.0