Cdk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	NM_199501.2	0.05	0.04	3.8e-04	0.03	0.03	0.04	0.03	6.9e-04	1.3e-03	3.3e-04	7.3e-04
2	pVTA	alternative TSS	XM_006240778.3	0.05	0.04	4.8e-03	0.01	0.01	0.01	0.01	3.1e-02	3.7e-02	6.6e-02	1.9e-02
3	Brain	alternative TSS	XM_006240778.3	0.05	0.04	8.0e-04	0.03	0.03	0.03	0.03	4.7e-04	1.6e-03	8.8e-04	1.1e-03
4	Liver	isoform ratio	XM_006240778.3	0.03	0.02	4.9e-03	0.02	0.01	0.01	0.01	5.8e-03	2.6e-02	1.2e-02	1.8e-02
5	Liver	alternative TSS	XM_006240778.3	0.03	0.02	7.9e-03	0.02	0.01	0.02	0.01	3.8e-03	1.2e-02	5.8e-03	7.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.9	1.5	-0.7	0.9	1.2	1.0	1.0
Area under the delay curve	0.2	0.2	0.5	-0.6	0.5	0.7	0.1	0.1
BMI with tail	8.7	30.2	32.2	-5.7	5.7	5.6	5.3	5.3
BMI without tail	2.4	7.3	8.2	-2.8	2.8	2.9	2.5	2.5
Body weight	1.2	5.4	6.5	-2.6	2.5	2.5	2.0	2.0
Weight adjusted by age	0.1	0.1	0.1	0.2	-0.3	-0.3	-0.3	-0.3
Bone surface	0.2	0.4	0.7	-0.1	0.3	0.7	0.9	0.9
Bone volume	0.5	0.9	1.4	-0.5	0.7	1.1	1.2	1.2
Breakpoint value in progressive ratio session	1.4	1.6	2.3	1.4	-1.3	-1.5	-1.1	-1.1
Number of licking bursts	2.0	3.3	4.0	-2.0	2.0	1.9	1.6	1.6
Context. condit. distance diff. score	0.2	0.3	0.3	-0.6	0.5	0.4	0.6	0.6
Locomotion velocity, session 1	0.5	0.5	0.8	-0.7	0.9	0.9	0.5	0.5
Locomotion distance, session 1	0.0	0.0	0.0	0.1	0.0	0.1	0.1	0.1
Locomotion velocity, session 2	0.6	0.6	1.1	1.0	-0.9	-0.8	-0.6	-0.6
Locomotion distance, session 2	1.3	1.8	2.2	1.4	-1.2	-1.1	-1.5	-1.5
Locomotion velocity, session 3	5.2	5.9	6.2	2.4	-2.3	-2.5	-2.5	-2.5
Locomotion distance, session 3	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.4	-0.4
Stereotopy head waving bouts, day 3	5.6	6.6	7.3	2.7	-2.6	-2.6	-2.5	-2.5
Stereotopy head waving duration, day 3	4.3	5.1	6.3	2.5	-2.5	-2.3	-1.9	-1.9
Locomotion velocity, session 7	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.0	-0.0
Locomotion distance, session 7	0.0	0.0	0.0	-0.2	0.1	0.0	0.1	0.1
Stereotopy head waving bouts, day 7	0.4	0.4	0.5	0.7	-0.6	-0.5	-0.7	-0.7
Stereotopy head waving duration, day 7	0.2	0.3	0.4	0.5	-0.5	-0.3	-0.6	-0.6
Locomotion velocity, session 8	0.3	0.4	0.6	0.6	-0.5	-0.3	-0.8	-0.8
Locomotion distance, session 8	0.2	0.2	0.4	0.4	-0.4	-0.4	-0.6	-0.6
Degree of sensitization distance	0.7	0.7	0.8	-0.8	0.8	0.9	0.9	0.9
Degree of sensitization stereotypy	0.2	0.3	0.4	-0.6	0.6	0.6	0.4	0.4
Conditioned locomotion	0.3	0.4	0.7	-0.8	0.8	0.6	0.4	0.4
Cocaine response after cond. corrected	1.3	1.6	2.0	-1.4	1.4	1.2	1.1	1.1
Cocaine response after cond. not corrected	1.2	1.4	1.8	-1.3	1.3	1.1	1.1	1.1
Cocaine response before conditioning	0.5	0.6	0.8	0.8	-0.9	-0.8	-0.7	-0.7
Saline control response	0.4	0.5	0.8	-0.9	0.9	0.9	0.5	0.5
Bone: connectivity density	0.2	0.4	0.6	-0.4	0.5	0.8	0.6	0.6
Bone: cortical apparent density	1.3	1.7	2.2	-1.2	1.2	1.2	1.5	1.5
Bone: cortical area	1.4	2.1	3.0	-1.2	1.2	1.4	1.7	1.7
Bone: cortical porosity	0.1	0.1	0.2	-0.0	0.1	0.0	0.4	0.4
Bone: cortical porosity	0.3	0.4	0.7	-0.3	0.4	0.4	0.9	0.9
Bone: cortical thickness	2.0	3.4	4.5	-1.6	1.6	1.7	2.1	2.1
Bone: cortical thickness	0.6	0.7	0.8	-0.9	0.8	0.8	0.8	0.8
Bone: cortical tissue density	0.9	1.2	1.5	-1.0	1.0	1.0	1.2	1.2
Condit. Reinf. active minus inactive responses	2.1	2.3	2.7	1.6	-1.6	-1.6	-1.4	-1.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.8	0.8	-0.9	-0.9	-0.6	-0.6
Condit. Reinf. active responses	2.3	2.9	3.5	1.9	-1.8	-1.8	-1.5	-1.5
Condit. Reinf. inactive responses	0.7	0.9	1.1	1.0	-1.0	-0.9	-1.0	-1.0
Incentive salience index mean	0.9	1.1	1.3	1.1	-1.1	-1.1	-0.9	-0.9
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	0.1	0.1	-0.2	-0.2
Condit. Reinf. active minus inactive responses	3.4	4.4	4.8	2.1	-2.2	-2.2	-2.0	-2.0
Condit. Reinf. active-inactive response ratio	1.5	1.8	2.0	1.2	-1.2	-1.4	-1.4	-1.4
Condit. Reinf. active responses	2.2	3.0	3.6	1.9	-1.9	-1.8	-1.6	-1.6
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.7	-0.7	-0.5	-0.4	-0.4
Condit. Reinf. lever presses	3.3	4.6	4.9	2.2	-2.2	-2.1	-2.1	-2.1
Condit. Reinf. lever reinforcers received	1.8	2.6	3.0	1.7	-1.7	-1.7	-1.5	-1.5
Conditioned reinforcement - actives	0.1	0.2	0.4	0.5	-0.7	-0.2	0.3	0.3
Conditioned reinforcement - inactives	0.1	0.2	0.4	0.2	-0.4	-0.0	0.6	0.6
Conditioned locomotion	2.9	3.7	6.2	2.4	-2.5	-2.0	-1.1	-1.1
Patch foraging indifference point 0 sec	3.7	6.8	8.0	-2.5	2.4	2.5	2.8	2.8
Patch foraging indifference point AUC	0.8	1.2	1.3	1.0	-1.0	-1.0	-1.1	-1.1
Delay disc. indifference point, 0s delay	3.4	3.8	5.2	-2.0	2.0	2.3	1.7	1.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.4	-0.4
Delay disc. indifference point, 2s delay	0.8	0.9	1.3	-1.0	1.1	1.2	0.7	0.7
Delay disc. indifference point, 24s delay	0.5	0.5	0.9	-0.9	0.8	1.0	0.4	0.4
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	0.1	-0.0	0.1	-0.2	-0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	-0.5	0.5	0.6	0.1	0.1
Indifference point function ln k	0.0	0.1	0.2	-0.0	0.0	-0.0	0.4	0.4
Indifference point function log k	0.0	0.1	0.2	-0.0	0.0	-0.0	0.4	0.4
Patch foraging total patch changes 0 sec	3.2	5.9	7.1	-2.3	2.3	2.3	2.7	2.7
Patch foraging total patch changes 12 sec	1.7	2.2	2.4	-1.5	1.5	1.5	1.4	1.4
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	-0.3	0.3	0.3	0.2	0.2
Patch foraging total patch changes 24 sec	0.6	0.9	1.1	-1.0	1.1	1.0	0.9	0.9
Patch foraging total patch changes 6 sec	2.0	3.1	3.6	-1.6	1.6	1.7	1.9	1.9
Patch foraging time to switch 0 sec	0.4	0.9	1.5	-1.0	1.0	1.2	0.8	0.8
Patch foraging water rate 0 sec	0.1	0.3	0.4	-0.5	0.5	0.4	0.6	0.6
Patch foraging water rate 12 sec	0.2	0.4	0.6	-0.6	0.6	0.4	0.7	0.7
Patch foraging water rate 18 sec	0.3	0.5	0.9	0.5	-0.7	-0.9	-0.6	-0.6
Patch foraging water rate 24 sec	0.3	0.4	0.7	-0.9	0.7	0.4	0.6	0.6
Patch foraging water rate 6 sec	1.2	1.7	2.7	1.3	-1.4	-1.6	-1.0	-1.0
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	2.1	1.5	-1.5	-1.1	-0.9	-0.9
Distance traveled before self-admin	1.4	1.9	2.1	1.4	-1.4	-1.4	-1.3	-1.3
Distance traveled after self-admin	0.0	0.0	0.0	-0.1	0.2	0.2	-0.2	-0.2
Extensor digitorum longus weight	4.9	19.3	21.5	-4.6	4.5	4.4	4.2	4.2
Bone: elastic displacement	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	0.1
Bone: elastic work	1.3	1.7	1.8	-1.3	1.3	1.3	1.3	1.3
Bone: endosteal estimation	0.7	1.4	2.0	-1.0	0.9	1.1	1.4	1.4
Bone: endosteal perimeter	0.1	0.3	0.5	0.7	-0.7	-0.5	-0.2	-0.2
Epididymis fat weight	0.1	0.4	0.6	0.5	-0.6	-0.6	-0.8	-0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.5	0.3	0.2	0.6	0.6
Delta time in open arm before/after self-admin	1.3	1.3	1.9	-1.3	1.4	1.4	0.7	0.7
Diff in mean of infusions in LGA sessions	2.6	3.1	3.6	1.8	-1.8	-1.9	-1.6	-1.6
Delay discount exponential model param	0.1	0.1	0.3	0.4	-0.4	-0.6	0.0	0.0
Extinction: sum of active levers before priming	2.5	2.7	3.0	1.6	-1.6	-1.7	-1.6	-1.6
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.3	-0.3
Bone: final force	4.1	6.6	7.3	-2.4	2.4	2.7	2.6	2.6
Bone: final moment	4.1	6.5	7.2	-2.4	2.4	2.7	2.6	2.6
Food consumed during 24 hour testing period	0.4	0.6	0.7	-0.8	0.8	0.8	0.7	0.7
Glucose	1.7	2.7	3.2	-1.8	1.8	1.8	1.4	1.4
Heart weight	0.5	0.7	0.8	0.8	-0.9	-0.9	-0.8	-0.8
Delay discount hyperbolic model param	0.4	0.5	0.9	0.8	-0.8	-0.9	-0.4	-0.4
Intermittent access intake day 1-15 change	0.9	1.9	2.7	1.6	-1.7	-1.7	-0.9	-0.9
Intermittent access intake escalation	0.8	1.7	2.4	1.5	-1.6	-1.6	-0.9	-0.9
Intermittent access intake escalation 2	1.4	1.6	2.3	1.4	-1.4	-1.5	-1.0	-1.0
Intermitt. access day 1 inactive lever presses	0.4	1.6	1.7	1.2	-1.3	-1.3	-1.2	-1.2
Intermitt. access day 15 inactive lever presses	0.7	1.5	1.6	1.2	-1.2	-1.3	-1.2	-1.2
Intermitt. access escalation Index	0.2	0.2	0.3	-0.4	0.4	0.5	0.5	0.5
Intermittent access day 1 total infusions	0.1	0.1	0.2	-0.1	0.1	0.5	0.4	0.4
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.6	-0.7	-0.3	0.2	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.6	-0.6	-0.3	0.2	0.2
Intermittent access total infusions	0.1	0.1	0.3	0.1	-0.2	0.2	0.5	0.5
Intermittent access day 1 locomotion	0.0	0.0	0.0	0.2	-0.2	-0.1	-0.1	-0.1
Intermittent access day 15 total locomotion	0.6	1.2	2.2	1.4	-1.5	-1.2	-0.5	-0.5
Intermittent access total locomotion	0.3	0.4	0.7	0.8	-0.9	-0.5	-0.4	-0.4
Intermittent access standard deviation	0.8	1.6	2.7	1.6	-1.6	-1.4	-0.6	-0.6
Left kidney weight	0.0	0.0	0.0	-0.2	0.1	0.1	-0.2	-0.2
Right kidney weight	0.2	0.8	1.2	0.7	-0.7	-0.8	-1.1	-1.1
Cocaine induced anxiety	0.7	1.0	1.3	1.1	-1.1	-0.9	-0.9	-0.9
Post-drug Anxiety	0.1	0.1	0.3	0.6	-0.5	-0.2	-0.2	-0.2
Baseline Anxiety	0.0	0.0	0.0	-0.1	0.1	0.2	0.2	0.2
Tail length	3.9	15.3	15.6	3.9	-3.9	-3.8	-4.0	-4.0
Length with tail	1.8	7.9	8.2	2.7	-2.8	-2.8	-2.9	-2.9
Length without tail	0.1	0.4	0.6	-0.8	0.7	0.6	0.6	0.6
Times rat made contact with spout	0.9	1.0	1.3	-1.1	1.1	1.0	0.9	0.9
Lifetime Intake	0.6	0.7	1.5	-0.3	0.2	0.7	1.2	1.2
Liver weight, left	0.4	0.7	0.9	-0.9	0.8	0.9	0.8	0.8
Liver weight, right	0.1	0.2	0.5	0.2	-0.2	-0.2	-0.7	-0.7
Locomotor activity	2.5	4.0	4.2	2.0	-1.9	-1.9	-2.0	-2.0
Locomotor testing distance	1.1	1.9	2.3	1.5	-1.4	-1.3	-1.3	-1.3
Locomotor testing rearing	0.0	0.1	0.1	0.1	-0.1	-0.2	-0.3	-0.3
Locomotion in novel chamber	0.1	0.1	0.2	0.0	-0.0	0.1	0.4	0.4
Locomotion in novel chamber post-restriction	3.7	6.1	6.3	2.5	-2.5	-2.4	-2.5	-2.5
Fecal boli incidents, locomotor time 1	0.4	0.6	1.0	-1.0	1.0	0.8	0.5	0.5
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	0.6	-0.5	-0.4	-0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.9	1.0	1.1	-0.9	0.9	1.1	1.0	1.0
Bouts of movement, locomotor time 1	0.8	1.0	1.1	1.0	-1.0	-1.0	-0.9	-0.9
Total resting periods, locomotor time 1	1.6	1.8	1.8	1.3	-1.3	-1.3	-1.3	-1.3
Rest time, locomotor task time 1	0.3	0.4	0.5	0.6	-0.5	-0.5	-0.7	-0.7
Distance moved, locomotor task time 1	0.9	1.3	1.6	-1.0	1.0	1.1	1.3	1.3
Vertical activity count, locomotor time 1	0.5	1.2	1.7	-0.9	0.9	0.9	1.3	1.3
Time >=10cm from walls, locomotor time 2	0.6	0.9	0.9	-0.9	0.9	0.9	1.0	1.0
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.3	-0.2	-0.1	-0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.2	-0.2	0.0	0.0	0.0
Rest time, locomotor task time 2	0.0	0.0	0.0	0.0	0.0	0.2	-0.0	-0.0
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.1	-0.2	-0.3	-0.1	-0.1
Vertical activity count, locomotor time 2	0.4	0.6	0.8	-0.9	0.8	0.6	0.8	0.8
Light reinforcement 1	2.9	7.0	8.4	2.9	-2.9	-2.8	-2.3	-2.3
Light reinforcement 2	1.0	1.6	2.0	1.3	-1.4	-1.3	-1.1	-1.1
Bone: marrow area	0.6	1.3	1.8	-0.9	0.9	1.0	1.3	1.3
Bone: maximum diameter	0.2	0.3	0.7	0.8	-0.8	-0.5	-0.1	-0.1
Bone: maximum force	3.8	6.8	7.4	-2.5	2.5	2.7	2.7	2.7
Bone: maximum moment	3.9	6.8	7.4	-2.5	2.5	2.7	2.7	2.7
Mean time between licks in bursts	0.7	1.7	2.4	1.4	-1.6	-1.5	-1.0	-1.0
Mean num. licks in bursts	0.5	0.8	0.9	0.9	-0.9	-0.9	-0.8	-0.8
Cd content in liver	0.4	0.5	0.8	0.8	-0.9	-0.9	-0.3	-0.3
Co content in liver	3.6	4.2	4.4	2.0	-2.1	-2.1	-2.0	-2.0
Cu content in liver	0.5	0.6	1.1	-0.4	0.4	0.5	1.1	1.1
Fe content in liver	0.1	0.1	0.2	-0.2	0.1	0.1	0.4	0.4
K content in liver	0.5	0.5	0.8	0.8	-0.9	-0.6	-0.6	-0.6
Mg content in liver	0.9	0.9	1.1	1.0	-1.0	-0.8	-1.0	-1.0
Mn content in liver	0.5	0.6	1.0	1.0	-0.9	-0.6	-0.6	-0.6
Na content in liver	0.2	0.2	0.3	-0.4	0.4	0.6	0.4	0.4
Rb content in liver	0.4	0.4	0.8	-0.4	0.4	0.5	0.9	0.9
Se content in liver	0.0	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1
Sr content in liver	0.6	0.5	0.8	0.8	-0.9	-0.8	-0.4	-0.4
Zn content in liver	4.5	5.0	5.4	2.2	-2.3	-2.3	-2.2	-2.2
Bone: minimum diameter	0.4	0.8	1.2	-0.6	0.6	0.8	1.1	1.1
Time in familiar zone, hab. session 1	5.7	5.5	6.1	2.2	-2.2	-2.3	-2.5	-2.5
Time in novel zone, hab. session 1	4.7	4.7	5.3	-2.0	2.0	2.2	2.3	2.3
Total zone transitions, hab. session 1	0.0	0.1	0.1	0.2	-0.1	-0.0	-0.3	-0.3
Total locomotion distance, hab. session 1	0.6	0.8	1.1	1.1	-1.0	-0.7	-0.9	-0.9
Locomotion velocity, hab. session 1	0.9	1.3	1.6	1.3	-1.2	-1.0	-1.1	-1.1
Time in familiar zone, hab. session 2	6.6	7.0	7.7	2.6	-2.6	-2.8	-2.6	-2.6
Time in novel zone, hab. session 2	7.4	7.5	8.1	-2.7	2.7	2.8	2.8	2.8
Total zone transitions, hab. session 2	1.2	1.5	1.6	-1.1	1.2	1.3	1.3	1.3
Total locomotion distance, hab. session 2	0.0	0.1	0.1	0.2	-0.2	-0.1	-0.3	-0.3
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.2	-0.2	-0.0	-0.3	-0.3
Novel to familiar place preference ratio	4.0	4.4	4.7	-2.0	2.1	2.2	2.1	2.1
Novelty place preference	2.7	2.9	3.1	-1.6	1.6	1.7	1.8	1.8
Time in novel zone, NPP test	3.4	3.6	4.0	-1.8	1.8	1.9	2.0	2.0
Total zone transitions, NPP test	0.8	1.2	1.6	-1.1	1.2	1.3	0.9	0.9
Total locomotion distance, NPP test	0.3	0.3	0.5	-0.6	0.7	0.7	0.5	0.5
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.3	0.3	0.4	0.1	0.1
Intraocular pressure	0.5	0.7	1.2	0.5	-0.5	-0.7	-1.1	-1.1
Delta distance traveled before/after self-admin	0.8	0.8	1.1	-1.0	1.0	1.1	0.7	0.7
Delta ambulatory time before/after self-admin	0.9	1.2	1.6	-1.1	1.1	1.3	0.9	0.9
Parametrial fat weight	0.5	1.2	1.5	-1.0	1.1	1.2	1.1	1.1
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.2	-0.2	-0.3	-0.2	-0.2
Pavlov. Cond. magazine entry latency	1.5	1.9	2.2	1.4	-1.4	-1.5	-1.3	-1.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.4	0.4	0.3	0.6	0.6
Pavlov. Cond. index score	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.5
Pavlov. Cond. latency score	0.1	0.2	0.2	0.5	-0.4	-0.4	-0.4	-0.4
Pavlov. Cond. lever contacts	0.2	0.2	0.2	-0.4	0.5	0.5	0.4	0.4
Pavlov. Cond. magazine entry number	0.6	0.8	0.9	-0.9	0.9	1.0	0.9	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	0.5	-0.5	-0.6	-0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.4	0.6	-0.6	-0.6	-0.6	-0.6
Pavlov. Cond. response bias	0.5	0.6	0.6	0.7	-0.7	-0.8	-0.8	-0.8
Pavlov. Cond. lever latency	1.6	2.1	2.4	-1.5	1.4	1.3	1.5	1.5
Pavlov. Cond. magazine entry latency	2.1	2.5	2.7	1.7	-1.6	-1.4	-1.6	-1.6
Pavlov. Cond. change in total contacts	0.8	1.3	1.5	1.2	-1.2	-1.1	-1.1	-1.1
Pavlov. Cond. index score	2.0	2.7	3.0	1.7	-1.7	-1.6	-1.6	-1.6
Pavlov. Cond. latency score	2.1	2.7	2.9	1.7	-1.7	-1.5	-1.7	-1.7
Pavlov. Cond. lever contacts	1.6	2.2	2.4	1.5	-1.5	-1.4	-1.5	-1.5
Pavlov. Cond. magazine entry number	2.2	2.7	3.1	-1.8	1.7	1.5	1.6	1.6
Pavlov. Cond. intertrial magazine entries	0.6	0.9	1.1	-1.0	1.0	0.9	1.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	2.2	3.0	3.4	1.8	-1.8	-1.7	-1.6	-1.6
Pavlov. Cond. response bias	2.6	3.6	3.7	1.9	-1.9	-1.8	-1.9	-1.9
Time in closed arm before self-admin	0.3	0.3	0.4	-0.4	0.5	0.6	0.6	0.6
Time in closed arm after self-admin	0.3	0.3	0.8	-0.1	0.1	0.2	0.9	0.9
Time in open arm before self-admin	0.1	0.1	0.3	0.4	-0.5	-0.5	0.1	0.1
Time in open arm after self-admin	1.8	1.9	2.5	-1.6	1.6	1.6	1.1	1.1
Bone: periosteal estimation	1.3	2.8	4.0	-1.4	1.3	1.6	2.0	2.0
Bone: periosteal perimeter	0.1	0.2	0.4	-0.1	0.1	0.3	0.7	0.7
Bone: post-yield work	0.5	0.8	1.0	-0.9	0.9	1.0	0.9	0.9
Progressive ratio test 1 active lever presses	0.3	0.4	0.6	-0.4	0.3	0.7	0.7	0.7
Progressive ratio test 1 breakpoint	0.3	0.4	0.6	-0.4	0.3	0.7	0.7	0.7
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.1	1.0	-1.0	-0.8	-0.3	-0.3
Progressive ratio test 2 active lever presses	0.1	0.2	0.4	0.6	-0.6	-0.3	-0.1	-0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	0.6	-0.7	-0.4	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	-0.0	-0.0	0.3	0.6	0.6
Incentive Sensitization - Responses	0.4	0.6	0.7	0.7	-0.7	-0.8	-0.8	-0.8
Incentive Sensitization - Breakpoint	0.5	0.7	0.8	0.8	-0.8	-0.9	-0.8	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.4	-0.4	-0.6	-0.4	-0.4
Progressive ratio	0.7	1.1	1.5	-0.9	0.9	0.9	1.2	1.2
Food seeking constrained by brief footshock	1.7	2.1	3.0	1.2	-1.2	-1.3	-1.7	-1.7
Seeking ratio, punishment vs. effort	2.1	3.1	4.2	1.5	-1.5	-1.5	-2.1	-2.1
Retroperitoneal fat weight	1.7	7.1	7.8	-2.8	2.7	2.6	2.6	2.6
Reaction time number correct	0.4	0.7	1.1	-1.0	0.9	0.8	0.7	0.7
Reaction time mean minus median	0.6	1.6	1.6	1.3	-1.3	-1.3	-1.3	-1.3
Reaction time mean minus median AUC	0.3	0.8	1.0	1.0	-0.9	-0.8	-0.9	-0.9
Reaction time num false alarms	0.6	0.9	1.0	-1.0	1.0	1.0	0.9	0.9
Reaction time num false alarms AUC	0.5	0.8	1.0	-1.0	1.0	0.9	0.8	0.8
Reaction time trials correct on left	0.4	0.7	1.1	-1.0	0.9	0.8	0.7	0.7
Reaction time trials on left	0.4	0.7	1.1	-1.0	0.9	0.8	0.7	0.7
Reaction time mean	0.6	0.9	1.0	1.0	-0.9	-0.9	-1.0	-1.0
Reaction time mean AUC	0.2	0.3	0.3	0.6	-0.5	-0.5	-0.5	-0.5
Median of all reaction times	0.3	0.4	0.5	0.7	-0.6	-0.6	-0.7	-0.7
Reaction time omissions	0.0	0.0	0.1	0.0	-0.1	-0.0	0.3	0.3
Reaction time false alarm rate	0.2	0.3	0.4	-0.6	0.6	0.7	0.5	0.5
Reaction time premature initiation rate	2.0	2.8	3.1	1.5	-1.6	-1.7	-1.8	-1.8
Reaction time premature initiations	0.9	1.6	1.9	1.0	-1.1	-1.3	-1.4	-1.4
Std. dev. reaction times	0.3	0.6	0.7	0.8	-0.8	-0.7	-0.8	-0.8
Reaction time trials completed	0.4	0.7	1.1	-1.0	0.9	0.8	0.7	0.7
Reaction time trials AUC	0.4	0.8	1.2	-1.1	1.0	0.8	0.7	0.7
Run reversals in cocaine runway, females	2.0	2.0	2.2	1.5	-1.3	-1.3	-1.5	-1.5
Run reversals in cocaine runway, males	1.9	1.9	2.5	1.6	-1.5	-1.4	-1.2	-1.2
Latency to leave start box in cocaine runway	0.6	0.7	1.0	-0.9	0.8	1.0	0.7	0.7
Latency to leave start box in cocaine runway, F	0.9	1.0	1.3	-1.0	1.0	1.1	0.8	0.8
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1	-0.1
Std. dev. time between licks in bursts	0.4	0.5	0.8	0.9	-0.9	-0.8	-0.5	-0.5
Total sessions with >9 infusions	0.5	0.6	1.4	0.1	-0.1	0.3	1.2	1.2
Short access day 1 total inactive lever presses	0.7	1.0	1.2	1.1	-1.1	-1.0	-0.9	-0.9
Short access day 10 total inactive lever presses	0.4	0.9	1.1	1.0	-1.1	-1.0	-0.8	-0.8
Short access day 1 total infusions	0.5	0.6	1.5	0.1	-0.2	0.1	1.2	1.2
Short access day 10 total infusions	0.1	0.2	0.4	0.0	-0.0	0.3	0.6	0.6
Short access total infusions	0.8	1.0	2.2	-0.3	0.2	0.6	1.5	1.5
Short access day 1 locomotion	1.0	1.2	2.3	1.4	-1.5	-1.1	-0.6	-0.6
Short access day 10 total locomotion	3.0	5.5	7.3	2.6	-2.7	-2.6	-1.8	-1.8
Short access total locomotion	1.0	1.2	2.1	1.4	-1.5	-1.1	-0.6	-0.6
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.1	0.0	0.3	0.3	0.3
Compulsive drug intake	0.0	0.0	0.0	-0.0	-0.0	0.1	-0.1	-0.1
One hour access (shock baseline)	0.1	0.2	0.4	0.6	-0.6	-0.5	-0.2	-0.2
Social response proportion	0.7	0.8	1.2	0.8	-0.6	-0.7	-1.1	-1.1
Social responses	8.0	10.3	11.3	3.2	-3.1	-3.0	-3.4	-3.4
Social time	1.0	1.4	1.7	-1.3	1.3	1.1	1.0	1.0
Soleus weight	6.7	19.7	21.3	-4.6	4.6	4.5	4.3	4.3
Bone: stiffness	4.9	8.0	8.4	-2.7	2.7	2.9	2.9	2.9
Tibialis anterior weight	1.5	5.2	5.8	-2.4	2.4	2.3	2.1	2.1
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.4	1.2	-1.1	-1.0	-0.7	-0.7
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.1	0.7	-0.7	-1.0	-1.1	-1.1
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.6	-0.6	-0.4	-0.3	-0.3
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.0	0.1	0.1	0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.4	-1.2	1.1	0.8	0.4	0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	0.0	-0.1	-0.3	-0.3	-0.3
Tibia length	1.0	2.8	3.4	1.6	-1.7	-1.5	-1.8	-1.8
Ambulatory time before self-admin	0.4	0.6	0.8	0.8	-0.8	-0.9	-0.7	-0.7
Ambulatory time after self-admin	0.0	0.0	0.1	-0.2	0.2	0.2	-0.0	-0.0
Bone: tissue strength	6.2	6.3	7.1	-2.4	2.4	2.4	2.7	2.7
Total heroin consumption	1.9	2.2	2.4	1.5	-1.4	-1.5	-1.6	-1.6
Bone: trabecular number	0.0	0.1	0.1	0.3	-0.1	0.2	-0.3	-0.3
Bone: trabecular spacing	0.1	0.2	0.4	0.2	-0.4	-0.7	-0.3	-0.3
Bone: trabecular thickness	1.2	1.4	2.0	-0.9	1.0	1.4	1.3	1.3
Bone: trabecular tissue density	4.1	6.0	6.3	-2.5	2.4	2.4	2.5	2.5
Water consumed over 24 hours	1.0	1.3	1.5	-1.1	1.1	1.2	1.2	1.2
Number of responses in last shaping day	4.0	4.4	6.2	2.4	-2.5	-2.3	-1.5	-1.5