Hub : Genes

Cdk2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	alternative TSS	NM_199501.2	0.05	0.04	8.2e-04	0.02	0.02	0.02	0.02	8.0e-03	8.0e-03	8.2e-03	9.5e-03
2	Brain	alternative TSS	XM_006240778.2	0.05	0.04	2.1e-03	0.02	0.01	0.01	0.01	4.3e-03	3.3e-02	1.6e-02	1.7e-02
3	Liver	alternative TSS	XM_006240778.2	0.03	0.02	6.7e-03	0.02	0.01	0.02	0.02	2.9e-03	8.0e-03	4.5e-03	4.3e-03
4	Liver	isoform ratio	XM_006240778.2	0.04	0.03	9.2e-04	0.02	0.02	0.02	0.02	1.5e-03	1.3e-03	2.0e-03	1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.7	1.1	2.9	-0.0	-0.9	-0.8	1.7
Area under the delay curve	0.2	0.2	0.4	-0.4	-0.6	-0.0	0.6
BMI with tail	7.7	24.9	28.0	-5.3	-5.2	-5.1	4.3
BMI without tail	1.2	2.6	3.5	-1.9	-1.7	-1.6	1.1
Body weight	1.4	5.9	7.1	-2.6	-2.7	-2.3	2.0
Weight adjusted by age	0.1	0.1	0.2	0.0	0.3	0.2	-0.5
Bone surface	0.7	1.3	3.9	0.5	-0.5	-0.9	2.0
Bone volume	1.0	1.7	4.8	0.3	-0.9	-1.1	2.2
Breakpoint value in progressive ratio session	2.9	3.2	4.1	1.6	2.0	1.7	-1.7
Number of licking bursts	2.5	3.0	4.5	-2.1	-1.8	-1.7	1.1
Context. condit. distance diff. score	0.2	0.2	0.3	-0.5	-0.4	-0.5	0.3
Locomotion velocity, session 1	0.6	0.7	1.5	-0.4	-0.9	-0.5	1.2
Locomotion distance, session 1	0.2	0.2	0.6	0.3	-0.1	-0.1	0.8
Locomotion velocity, session 2	0.5	0.6	1.4	1.2	0.8	0.5	0.2
Locomotion distance, session 2	1.1	1.6	3.2	1.8	1.0	1.4	-0.3
Locomotion velocity, session 3	4.9	5.7	6.3	2.5	2.4	2.5	-2.1
Locomotion distance, session 3	0.1	0.1	0.2	0.2	0.2	0.4	-0.4
Stereotopy head waving bouts, day 3	5.3	6.2	8.1	2.8	2.6	2.5	-1.9
Stereotopy head waving duration, day 3	3.8	4.6	6.1	2.5	2.4	1.9	-1.7
Locomotion velocity, session 7	0.0	0.0	0.1	0.3	0.3	0.1	0.1
Locomotion distance, session 7	0.0	0.1	0.1	-0.2	0.0	-0.1	-0.4
Stereotopy head waving bouts, day 7	0.3	0.4	0.7	0.9	0.5	0.7	0.1
Stereotopy head waving duration, day 7	0.2	0.2	0.5	0.7	0.2	0.6	0.3
Locomotion velocity, session 8	0.4	0.4	1.0	1.0	0.3	0.8	0.3
Locomotion distance, session 8	0.1	0.2	0.3	0.6	0.3	0.6	-0.2
Degree of sensitization distance	0.6	0.6	0.7	-0.8	-0.7	-0.8	0.7
Degree of sensitization stereotypy	0.4	0.5	0.9	-0.5	-0.8	-0.4	0.9
Conditioned locomotion	0.5	0.5	1.4	-1.2	-0.7	-0.5	0.1
Cocaine response after cond. corrected	1.3	1.4	2.6	-1.6	-1.2	-1.2	0.4
Cocaine response after cond. not corrected	1.2	1.3	2.5	-1.6	-1.1	-1.2	0.3
Cocaine response before conditioning	0.4	0.5	0.8	0.9	0.8	0.7	-0.5
Saline control response	0.3	0.4	0.7	-0.8	-0.8	-0.6	0.4
Bone: connectivity density	0.3	0.5	1.4	0.1	-0.6	-0.6	1.2
Bone: cortical apparent density	1.3	1.8	2.3	-1.4	-1.3	-1.5	1.1
Bone: cortical area	1.6	2.4	3.7	-1.1	-1.3	-1.8	1.9
Bone: cortical porosity	0.0	0.1	0.1	0.3	0.2	-0.2	0.3
Bone: cortical porosity	0.3	0.4	0.7	-0.1	-0.4	-0.8	0.8
Bone: cortical thickness	1.8	2.9	3.7	-1.5	-1.5	-1.9	1.8
Bone: cortical thickness	0.6	0.7	1.1	-1.1	-0.8	-0.9	0.5
Bone: cortical tissue density	0.9	1.2	1.6	-1.2	-1.1	-1.3	0.9
Condit. Reinf. active minus inactive responses	2.0	2.2	2.9	1.7	1.7	1.4	-1.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.9	0.7	1.0	0.6	-0.9
Condit. Reinf. active responses	2.1	2.6	4.0	2.0	1.8	1.5	-0.9
Condit. Reinf. inactive responses	0.7	0.8	1.6	1.3	0.9	1.0	-0.2
Incentive salience index mean	0.8	1.0	1.6	1.3	1.1	0.9	-0.4
Condit. Reinf. lever presses	0.2	0.3	0.9	0.3	-0.3	0.0	0.9
Condit. Reinf. active minus inactive responses	3.1	3.9	4.7	1.8	2.2	1.8	-2.0
Condit. Reinf. active-inactive response ratio	1.6	1.7	2.8	0.8	1.3	1.2	-1.7
Condit. Reinf. active responses	1.8	2.5	3.2	1.7	1.8	1.4	-1.4
Condit. Reinf. inactive responses	0.2	0.2	0.6	0.7	0.5	0.3	-0.1
Condit. Reinf. lever presses	3.5	4.7	4.9	2.1	2.2	2.2	-2.2
Condit. Reinf. lever reinforcers received	1.5	2.1	2.7	1.4	1.6	1.3	-1.4
Conditioned reinforcement - actives	0.1	0.1	0.2	0.4	0.3	-0.3	0.2
Conditioned reinforcement - inactives	0.4	0.4	1.1	-0.8	-0.1	-1.0	-0.0
Conditioned locomotion	3.3	4.0	6.1	2.3	2.5	1.5	-1.5
Patch foraging indifference point 0 sec	3.8	6.2	7.6	-2.5	-2.4	-2.8	2.3
Patch foraging indifference point AUC	0.5	0.6	0.8	0.8	0.6	0.9	-0.8
Delay disc. indifference point, 0s delay	3.2	3.5	5.2	-1.4	-2.1	-1.5	2.3
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	0.4	0.4	0.6	-0.2
Delay disc. indifference point, 2s delay	0.7	0.7	1.1	-0.7	-1.0	-0.5	1.0
Delay disc. indifference point, 24s delay	0.5	0.5	0.8	-0.8	-0.9	-0.3	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.5	-0.0	0.4	0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.5	-0.5	0.1	-0.1
Indifference point function ln k	0.1	0.1	0.3	-0.3	-0.0	-0.6	0.3
Indifference point function log k	0.1	0.1	0.3	-0.3	-0.0	-0.6	0.3
Patch foraging total patch changes 0 sec	3.4	5.4	6.9	-2.4	-2.2	-2.6	2.1
Patch foraging total patch changes 12 sec	1.3	1.7	2.5	-1.6	-1.4	-1.4	0.8
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.2
Patch foraging total patch changes 24 sec	0.8	1.0	1.2	-1.0	-1.1	-0.9	1.0
Patch foraging total patch changes 6 sec	1.9	2.8	3.6	-1.7	-1.6	-1.9	1.5
Patch foraging time to switch 0 sec	0.5	0.8	1.2	-0.7	-1.1	-0.7	1.1
Patch foraging water rate 0 sec	0.2	0.3	0.6	-0.8	-0.3	-0.7	-0.0
Patch foraging water rate 12 sec	0.3	0.5	1.0	-1.0	-0.4	-0.8	0.1
Patch foraging water rate 18 sec	0.6	0.9	2.3	0.1	0.9	0.5	-1.5
Patch foraging water rate 24 sec	0.4	0.6	1.6	-1.3	-0.3	-0.5	-0.7
Patch foraging water rate 6 sec	1.3	1.9	3.2	0.9	1.6	0.9	-1.8
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	2.1	1.4	1.3	0.8	-0.6
Distance traveled before self-admin	0.7	0.8	1.0	1.0	0.9	0.9	-0.7
Distance traveled after self-admin	0.1	0.2	0.3	0.5	0.4	0.3	-0.2
Extensor digitorum longus weight	4.7	18.5	24.6	-5.0	-4.6	-4.3	3.1
Bone: elastic displacement	0.0	0.0	0.0	0.1	0.2	-0.1	0.1
Bone: elastic work	1.0	1.2	1.6	-1.0	-1.1	-1.1	1.3
Bone: endosteal estimation	0.8	1.7	2.5	-1.0	-1.1	-1.6	1.5
Bone: endosteal perimeter	0.1	0.2	0.5	0.7	0.5	0.1	0.3
Epididymis fat weight	0.1	0.2	0.3	0.3	0.4	0.6	-0.6
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	-0.7	0.1	-0.3	-0.8
Delta time in open arm before/after self-admin	2.3	2.2	3.1	-1.5	-1.8	-1.2	1.4
Diff in mean of infusions in LGA sessions	2.6	2.8	3.5	1.7	1.9	1.6	-1.5
Delay discount exponential model param	0.1	0.1	0.3	0.3	0.5	-0.1	-0.5
Extinction: sum of active levers before priming	4.2	4.2	5.1	1.7	1.9	2.3	-2.2
Active lever presses in extinction session 6	0.8	0.8	1.2	1.0	0.8	1.1	-0.6
Bone: final force	3.8	6.2	7.1	-2.2	-2.5	-2.5	2.7
Bone: final moment	3.6	5.9	6.8	-2.1	-2.5	-2.5	2.6
Food consumed during 24 hour testing period	0.5	0.6	0.7	-0.7	-0.8	-0.7	0.7
Glucose	1.9	2.8	3.6	-1.9	-1.7	-1.7	1.4
Heart weight	0.0	0.0	0.1	0.0	0.2	-0.1	-0.3
Delay discount hyperbolic model param	0.3	0.3	0.6	0.5	0.7	0.1	-0.7
Intermittent access intake day 1-15 change	1.0	1.0	2.1	0.9	1.5	0.4	-0.9
Intermittent access intake escalation	1.2	1.2	2.2	0.6	1.5	0.5	-1.4
Intermittent access intake escalation 2	2.0	1.9	3.2	1.0	1.8	1.0	-1.6
Intermitt. access day 1 inactive lever presses	0.8	0.8	1.5	0.5	1.2	0.5	-1.2
Intermitt. access day 15 inactive lever presses	1.8	2.0	3.1	1.1	1.7	1.2	-1.5
Intermitt. access escalation Index	0.2	0.2	0.4	0.4	0.1	-0.4	0.6
Intermittent access day 1 total infusions	0.5	0.6	0.7	-0.6	-0.8	-0.8	0.8
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.1	0.2	-0.4	-0.1
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.6	-0.2	-0.0	-0.8	0.5
Intermittent access total infusions	0.3	0.3	0.6	-0.5	-0.4	-0.8	0.4
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.0
Intermittent access day 15 total locomotion	1.0	1.1	2.0	1.0	1.4	0.5	-1.0
Intermittent access total locomotion	0.3	0.3	0.4	0.6	0.6	0.4	-0.4
Intermittent access standard deviation	0.7	0.7	1.6	0.7	1.3	0.3	-0.8
Left kidney weight	0.3	0.8	1.8	-0.4	-0.8	-0.8	1.4
Right kidney weight	0.2	0.4	0.8	0.9	0.8	0.5	-0.2
Cocaine induced anxiety	0.7	0.8	1.6	1.3	0.8	1.1	-0.3
Post-drug Anxiety	0.2	0.2	0.6	0.5	-0.2	0.1	0.8
Baseline Anxiety	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.2
Tail length	5.1	15.5	16.9	3.9	4.0	4.1	-3.7
Length with tail	1.4	5.2	6.2	2.4	2.3	2.5	-1.9
Length without tail	0.3	0.7	1.2	-0.5	-0.8	-0.7	1.1
Times rat made contact with spout	0.7	0.9	1.3	-1.2	-1.0	-0.9	0.5
Lifetime Intake	1.0	1.1	2.0	-0.9	-0.8	-1.4	1.1
Liver weight, left	1.1	1.8	2.4	-1.5	-1.3	-1.5	0.9
Liver weight, right	0.9	1.4	1.8	-1.2	-1.0	-1.3	1.1
Locomotor activity	2.3	3.6	5.2	2.3	1.9	2.1	-1.2
Locomotor testing distance	0.9	1.5	2.2	1.5	1.3	1.3	-0.8
Locomotor testing rearing	0.0	0.0	0.1	-0.0	0.1	0.3	-0.3
Locomotion in novel chamber	0.1	0.2	0.3	-0.4	-0.2	-0.6	0.3
Locomotion in novel chamber post-restriction	3.5	4.2	4.6	2.1	2.1	2.1	-1.8
Fecal boli incidents, locomotor time 1	0.4	0.4	0.9	-1.0	-0.7	-0.4	0.1
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.7	0.3	0.1	0.3
Time >=10cm from walls, locomotor time 1	1.1	1.1	1.8	-0.8	-1.1	-1.0	1.4
Bouts of movement, locomotor time 1	0.6	0.7	0.8	0.8	0.8	0.9	-0.8
Total resting periods, locomotor time 1	1.2	1.3	1.6	1.2	1.1	1.3	-1.0
Rest time, locomotor task time 1	0.3	0.3	0.5	0.7	0.4	0.7	-0.3
Distance moved, locomotor task time 1	1.2	1.3	1.8	-0.8	-0.9	-1.3	1.4
Vertical activity count, locomotor time 1	0.8	0.9	1.6	-1.0	-0.7	-1.3	0.7
Time >=10cm from walls, locomotor time 2	0.7	0.8	1.2	-1.1	-0.8	-1.0	0.5
Bouts of movement, locomotor time 2	0.1	0.1	0.3	0.5	0.2	0.4	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	0.5	0.1	0.3	0.4
Rest time, locomotor task time 2	0.1	0.1	0.2	0.1	-0.2	0.0	0.5
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.1	0.2	-0.1	-0.5
Vertical activity count, locomotor time 2	0.7	0.7	1.4	-1.2	-0.8	-0.9	0.2
Light reinforcement 1	3.6	6.6	8.6	2.8	2.9	2.4	-2.1
Light reinforcement 2	1.1	1.4	1.9	1.3	1.4	1.1	-1.0
Bone: marrow area	0.7	1.5	2.2	-1.0	-1.0	-1.5	1.4
Bone: maximum diameter	0.1	0.3	0.6	0.8	0.5	-0.0	0.5
Bone: maximum force	3.8	6.5	7.1	-2.3	-2.6	-2.7	2.7
Bone: maximum moment	3.7	6.3	7.0	-2.3	-2.5	-2.6	2.6
Mean time between licks in bursts	1.2	1.7	2.1	1.3	1.4	1.1	-1.4
Mean num. licks in bursts	0.6	0.7	1.0	1.0	0.9	0.9	-0.6
Cd content in liver	0.4	0.4	0.5	-0.6	-0.7	-0.6	0.6
Co content in liver	1.6	1.9	2.1	1.3	1.4	1.3	-1.5
Cu content in liver	1.5	1.8	2.7	-1.0	-1.0	-1.6	1.7
Fe content in liver	0.3	0.3	0.5	-0.7	-0.6	-0.6	0.2
K content in liver	0.3	0.3	0.6	0.8	0.5	0.5	0.0
Mg content in liver	0.1	0.1	0.3	0.5	-0.1	0.3	0.4
Mn content in liver	0.3	0.4	1.1	0.6	-0.0	-0.1	1.1
Na content in liver	0.3	0.3	0.6	-0.4	-0.5	-0.3	0.7
Rb content in liver	0.9	1.1	1.9	-0.6	-0.7	-1.3	1.4
Se content in liver	0.0	0.0	0.0	0.2	-0.0	0.2	-0.0
Sr content in liver	0.8	0.8	1.6	0.5	1.0	0.5	-1.2
Zn content in liver	3.3	3.6	5.4	1.4	1.8	1.9	-2.3
Bone: minimum diameter	0.5	0.8	1.4	-0.5	-0.7	-1.1	1.2
Time in familiar zone, hab. session 1	5.8	5.4	6.2	2.3	2.3	2.5	-2.2
Time in novel zone, hab. session 1	5.0	4.9	5.9	-1.9	-2.2	-2.3	2.4
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.7	0.1	0.4	0.4
Total locomotion distance, hab. session 1	0.6	0.9	2.1	1.5	0.8	0.9	0.3
Locomotion velocity, hab. session 1	0.8	1.2	2.5	1.6	1.0	1.1	-0.1
Time in familiar zone, hab. session 2	6.5	6.7	7.2	2.5	2.7	2.6	-2.6
Time in novel zone, hab. session 2	7.3	7.3	8.0	-2.5	-2.7	-2.7	2.8
Total zone transitions, hab. session 2	1.3	1.7	3.3	-0.8	-1.2	-1.2	1.8
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.5	0.1	0.3	0.4
Locomotion velocity, hab. session 2	0.1	0.2	0.4	0.5	-0.0	0.3	0.6
Novel to familiar place preference ratio	4.3	4.5	5.8	-1.8	-2.1	-2.1	2.4
Novelty place preference	3.0	3.0	4.1	-1.5	-1.7	-1.7	2.0
Time in novel zone, NPP test	3.6	3.7	4.7	-1.7	-1.9	-2.0	2.2
Total zone transitions, NPP test	0.7	1.1	1.6	-0.8	-1.2	-0.8	1.3
Total locomotion distance, NPP test	0.4	0.5	1.2	-0.3	-0.7	-0.5	1.1
Locomotion velocity, NPP test	0.1	0.2	0.6	0.0	-0.4	-0.1	0.8
Intraocular pressure	0.8	1.1	2.1	0.6	0.8	1.2	-1.5
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.3
Delta ambulatory time before/after self-admin	0.2	0.2	0.4	-0.2	-0.3	-0.4	0.6
Parametrial fat weight	0.1	0.2	0.3	0.3	0.4	0.3	-0.5
Pavlov. Cond. lever latency	0.1	0.1	0.5	-0.1	0.2	0.1	-0.7
Pavlov. Cond. magazine entry latency	1.7	2.3	2.5	1.5	1.6	1.5	-1.4
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	-0.4	-0.4	-0.6	0.4
Pavlov. Cond. index score	0.2	0.2	0.5	0.7	0.5	0.5	-0.1
Pavlov. Cond. latency score	0.2	0.2	0.6	0.7	0.4	0.4	0.1
Pavlov. Cond. lever contacts	0.3	0.3	1.0	-0.0	-0.5	-0.3	1.0
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	-0.8	-0.8	-0.8	0.7
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	0.2	0.6	0.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	0.9	0.6	0.6	-0.2
Pavlov. Cond. response bias	0.6	0.7	0.9	0.9	0.9	0.9	-0.7
Pavlov. Cond. lever latency	1.4	1.9	2.4	-1.5	-1.3	-1.5	1.2
Pavlov. Cond. magazine entry latency	2.1	2.5	3.3	1.8	1.5	1.6	-1.3
Pavlov. Cond. change in total contacts	0.8	1.2	1.4	1.2	1.1	1.0	-1.0
Pavlov. Cond. index score	2.1	2.7	3.3	1.8	1.6	1.7	-1.5
Pavlov. Cond. latency score	2.0	2.5	3.2	1.8	1.5	1.7	-1.3
Pavlov. Cond. lever contacts	1.5	2.1	2.3	1.5	1.4	1.5	-1.4
Pavlov. Cond. magazine entry number	2.0	2.5	3.2	-1.8	-1.6	-1.5	1.3
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.3	-1.1	-0.9	-0.9	0.4
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	3.5	1.9	1.7	1.6	-1.4
Pavlov. Cond. response bias	2.5	3.4	3.6	1.9	1.8	1.8	-1.7
Time in closed arm before self-admin	0.7	0.8	1.4	-0.5	-1.0	-0.7	1.2
Time in closed arm after self-admin	0.2	0.2	0.5	-0.4	-0.2	-0.7	0.3
Time in open arm before self-admin	1.0	1.1	2.0	0.9	1.4	0.5	-1.1
Time in open arm after self-admin	0.9	1.0	1.4	-1.2	-1.1	-0.9	0.7
Bone: periosteal estimation	1.6	3.3	4.8	-1.3	-1.5	-2.1	2.2
Bone: periosteal perimeter	0.3	0.4	1.1	0.0	-0.3	-0.7	1.1
Bone: post-yield work	0.4	0.5	0.6	-0.7	-0.6	-0.8	0.6
Progressive ratio test 1 active lever presses	1.2	1.2	1.8	-1.1	-1.1	-1.3	0.9
Progressive ratio test 1 breakpoint	1.4	1.4	2.0	-1.2	-1.2	-1.4	1.0
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.6	0.4	0.8	-0.4	-0.2
Progressive ratio test 2 active lever presses	0.4	0.5	0.9	-0.6	-0.5	-1.0	0.6
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	-0.2	-0.2	-0.8	0.6
Progressive ratio test 2 inactive lever presses	0.3	0.3	0.8	-0.3	-0.2	-0.9	0.6
Incentive Sensitization - Responses	0.2	0.2	0.4	0.5	0.6	0.2	-0.3
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.6	0.7	0.2	-0.3
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.4	0.6	0.6	0.6	-0.6
Progressive ratio	0.9	1.0	1.4	-1.1	-0.9	-1.2	0.7
Food seeking constrained by brief footshock	1.4	1.8	2.7	1.3	1.1	1.7	-1.2
Seeking ratio, punishment vs. effort	2.1	2.5	3.7	1.6	1.4	1.9	-1.3
Retroperitoneal fat weight	2.2	7.1	8.9	-3.0	-2.7	-2.8	2.0
Reaction time number correct	0.5	0.8	1.6	-1.2	-0.9	-0.7	0.3
Reaction time mean minus median	1.1	1.5	1.9	1.4	1.2	1.3	-1.0
Reaction time mean minus median AUC	0.6	0.8	1.7	1.3	0.7	0.9	-0.0
Reaction time num false alarms	0.5	0.7	0.9	-0.9	-0.9	-0.8	0.6
Reaction time num false alarms AUC	0.4	0.6	1.0	-1.0	-0.8	-0.8	0.4
Reaction time trials correct on left	0.5	0.8	1.6	-1.2	-0.9	-0.7	0.3
Reaction time trials on left	0.5	0.7	1.5	-1.2	-0.9	-0.7	0.3
Reaction time mean	0.6	0.8	1.5	1.2	0.7	1.0	-0.3
Reaction time mean AUC	0.2	0.3	0.6	0.8	0.3	0.5	0.0
Median of all reaction times	0.2	0.3	0.7	0.8	0.4	0.7	-0.0
Reaction time omissions	0.0	0.0	0.1	0.1	0.1	-0.2	0.3
Reaction time false alarm rate	0.2	0.2	0.3	-0.4	-0.5	-0.5	0.5
Reaction time premature initiation rate	2.2	2.9	3.5	1.4	1.7	1.8	-1.9
Reaction time premature initiations	1.3	1.8	3.1	0.7	1.3	1.4	-1.8
Std. dev. reaction times	0.5	0.6	1.2	1.1	0.7	0.9	-0.4
Reaction time trials completed	0.5	0.7	1.5	-1.2	-0.9	-0.7	0.3
Reaction time trials AUC	0.5	0.8	1.7	-1.3	-0.9	-0.7	0.2
Run reversals in cocaine runway, females	1.3	1.3	1.9	1.4	1.0	1.3	-0.7
Run reversals in cocaine runway, males	2.1	2.0	2.9	1.7	1.6	1.3	-1.0
Latency to leave start box in cocaine runway	0.8	0.9	1.8	-0.4	-1.0	-0.8	1.3
Latency to leave start box in cocaine runway, F	1.5	1.6	3.4	-0.5	-1.3	-1.0	1.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.1	0.2	0.1	-0.5
Std. dev. time between licks in bursts	0.3	0.4	0.8	0.9	0.8	0.3	0.2
Total sessions with >9 infusions	0.7	0.7	1.6	-0.1	-0.3	-1.3	1.1
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.2	0.3	-0.3	-0.0
Short access day 10 total inactive lever presses	0.4	0.4	0.8	0.3	0.9	0.1	-0.8
Short access day 1 total infusions	1.5	1.6	3.1	-0.6	-0.7	-1.8	1.5
Short access day 10 total infusions	0.7	0.8	1.4	-0.7	-0.7	-1.2	0.8
Short access total infusions	2.2	2.5	4.1	-1.1	-1.2	-2.0	1.7
Short access day 1 locomotion	0.1	0.1	0.2	0.5	0.2	-0.2	0.2
Short access day 10 total locomotion	3.1	3.5	5.3	1.8	2.3	1.4	-1.9
Short access total locomotion	0.2	0.3	0.5	0.7	0.7	0.2	-0.3
One hour access (0.3 mA shock)	0.3	0.4	0.6	-0.7	-0.6	-0.8	0.5
Compulsive drug intake	0.4	0.4	0.7	-0.6	-0.8	-0.5	0.5
One hour access (shock baseline)	0.1	0.1	0.2	-0.1	0.4	-0.2	-0.3
Social response proportion	0.5	0.5	1.0	0.8	0.6	1.0	-0.3
Social responses	7.0	9.0	12.0	3.5	2.9	3.3	-2.1
Social time	1.0	1.4	2.0	-1.4	-1.2	-1.1	0.9
Soleus weight	6.5	19.1	22.4	-4.7	-4.6	-4.3	3.7
Bone: stiffness	5.4	8.4	9.4	-2.8	-2.9	-3.1	2.8
Tibialis anterior weight	1.4	4.8	5.6	-2.3	-2.4	-2.1	1.9
Time to tail flick, vehicle, before self-admin	1.0	1.0	2.1	1.5	1.3	0.6	-0.1
Time to tail flick, vehicle, after self-admin	0.6	0.6	1.1	0.5	0.6	0.8	-1.0
Time to tail flick, test, before self-admin	0.4	0.4	1.0	1.0	0.5	0.6	0.0
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.3	-0.0	-0.1	0.5
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.5	-1.2	-1.1	-0.2	-0.2
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	0.1	0.4	0.5	-0.6
Tibia length	1.0	2.9	3.6	1.7	1.6	1.9	-1.6
Ambulatory time before self-admin	0.3	0.3	0.4	0.5	0.6	0.5	-0.4
Ambulatory time after self-admin	0.0	0.0	0.1	0.2	0.2	0.0	0.0
Bone: tissue strength	4.7	4.6	5.3	-2.1	-2.1	-2.3	2.1
Total heroin consumption	1.9	2.2	2.9	1.7	1.5	1.7	-1.1
Bone: trabecular number	0.2	0.3	0.9	0.9	0.2	0.5	0.4
Bone: trabecular spacing	0.5	0.6	1.9	-0.3	0.5	0.3	-1.4
Bone: trabecular thickness	1.9	2.3	5.9	-0.2	-1.2	-1.3	2.4
Bone: trabecular tissue density	4.6	6.5	8.6	-2.9	-2.6	-2.7	1.7
Water consumed over 24 hours	1.3	1.6	2.4	-1.0	-1.1	-1.3	1.5
Number of responses in last shaping day	1.5	1.5	2.7	1.4	1.7	0.7	-1.0