Hub : Genes

Cdh7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Cdh7	0.19	0.09	1.6e-10	0.05	0.08	0.08	0.08	2.1e-05	6.8e-08	1.4e-07	5.5e-08
2	Adipose	gene expression	Cdh7	0.05	0.04	2.4e-03	0.01	-0	-0	-0	4.2e-02	8.2e-01	4.5e-01	4.3e-01
3	LHb	gene expression	Cdh7	0.31	0.14	1.4e-04	0.07	0.14	0.13	0.12	8.8e-03	3.0e-04	5.7e-04	8.8e-04
4	NAcc	gene expression	Cdh7	0.26	0.11	1.1e-10	0.03	0.03	0.02	0.03	1.3e-05	4.5e-05	2.0e-04	6.4e-05
5	IC	alternative polyA	XM_017598763.3	0.11	0.07	9.4e-03	0.01	0.01	0.04	0.03	1.2e-01	7.6e-02	1.1e-02	2.5e-02
6	Brain	gene expression	Cdh7	0.08	0.05	1.1e-04	0.02	0.03	0.03	0.02	6.3e-03	3.6e-04	2.1e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.3	0.5	0.9	0.4	-0.5	0.6	0.9	0.8	0.8
Area under the delay curve	2.2	2.5	5.4	0.3	2.3	-1.5	-2.3	-1.2	-0.9
BMI with tail	0.9	3.1	5.4	-2.2	-0.1	-2.3	-1.8	-0.3	-2.3
BMI without tail	0.4	1.2	2.7	-0.9	0.6	-1.7	-1.4	0.5	-1.1
Body weight	0.6	2.8	5.6	-1.0	1.4	-2.2	-2.4	-0.8	-1.7
Weight adjusted by age	1.3	1.9	4.0	-1.6	-0.5	-0.8	-1.0	-2.0	-1.8
Bone surface	0.2	0.4	1.1	-0.7	-1.1	0.3	0.4	-0.4	-0.4
Bone volume	0.0	0.0	0.1	0.2	-0.1	0.1	0.2	0.2	0.3
Breakpoint value in progressive ratio session	0.3	0.4	0.8	-0.2	0.5	-0.9	-0.9	0.0	-0.5
Number of licking bursts	0.2	0.4	1.2	0.9	1.1	0.0	-0.4	-0.2	0.4
Context. condit. distance diff. score	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1	-0.2	-0.2
Locomotion velocity, session 1	1.0	1.1	1.8	-1.0	0.4	-1.3	-1.3	-0.5	-1.4
Locomotion distance, session 1	0.8	1.1	2.4	0.7	1.6	-0.1	-1.1	-1.5	-0.1
Locomotion velocity, session 2	1.5	1.7	4.0	0.5	2.0	-0.7	-1.6	-1.5	-0.6
Locomotion distance, session 2	1.3	1.9	4.9	1.3	1.9	0.5	-0.9	-2.2	0.2
Locomotion velocity, session 3	0.5	0.6	2.0	0.7	0.5	-0.3	0.1	1.4	0.8
Locomotion distance, session 3	0.5	0.6	2.7	-0.4	-0.4	-0.7	-0.0	1.6	0.0
Stereotopy head waving bouts, day 3	0.4	0.5	0.9	0.9	0.7	0.7	0.2	-1.0	0.5
Stereotopy head waving duration, day 3	0.5	0.6	1.9	0.7	0.4	1.0	0.3	-1.4	0.4
Locomotion velocity, session 7	0.4	0.4	1.3	-0.4	-1.1	0.3	0.8	0.7	0.2
Locomotion distance, session 7	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.1	-0.3	-0.1
Stereotopy head waving bouts, day 7	0.6	0.7	1.4	1.2	1.1	0.6	0.1	-0.9	0.7
Stereotopy head waving duration, day 7	0.1	0.1	0.3	0.3	0.5	-0.2	-0.3	-0.2	0.0
Locomotion velocity, session 8	1.1	1.3	2.5	1.4	0.1	1.6	1.1	-0.2	1.5
Locomotion distance, session 8	0.3	0.5	0.9	1.0	0.8	0.6	-0.0	-0.7	0.6
Degree of sensitization distance	0.4	0.4	1.8	0.3	0.5	0.4	-0.2	-1.3	-0.1
Degree of sensitization stereotypy	0.5	0.5	1.3	1.2	1.0	0.5	0.2	-0.2	0.8
Conditioned locomotion	0.1	0.2	0.3	-0.0	0.5	-0.3	-0.5	-0.4	-0.3
Cocaine response after cond. corrected	0.7	0.8	2.2	-0.7	-1.0	0.8	0.6	-1.5	-0.5
Cocaine response after cond. not corrected	0.5	0.5	1.3	-0.5	-0.9	0.8	0.5	-1.1	-0.3
Cocaine response before conditioning	0.3	0.4	1.0	0.8	0.4	0.1	0.1	1.0	0.7
Saline control response	1.4	1.9	4.2	2.1	1.7	1.2	0.1	-1.2	1.3
Bone: connectivity density	1.1	1.7	3.7	0.1	-1.7	1.5	1.9	0.8	1.0
Bone: cortical apparent density	1.9	2.6	4.5	2.0	0.6	2.1	1.4	-0.7	1.9
Bone: cortical area	0.5	0.7	1.6	1.0	0.1	1.3	0.8	-0.6	0.9
Bone: cortical porosity	0.1	0.1	0.3	-0.1	-0.5	0.1	0.3	0.4	0.1
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.1	0.1	-0.1
Bone: cortical thickness	0.7	1.1	1.9	0.9	-0.5	1.2	1.4	0.7	1.3
Bone: cortical thickness	2.3	2.7	4.8	1.8	-0.2	1.8	1.9	1.2	2.2
Bone: cortical tissue density	1.7	2.3	4.1	2.0	0.8	2.0	1.2	-0.7	1.8
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	-0.5	0.2	-1.1	-0.6	0.8	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	-0.3	0.2	0.6	0.4	0.3
Condit. Reinf. active responses	1.1	1.4	3.4	-0.9	0.3	-1.9	-1.2	1.1	-1.0
Condit. Reinf. inactive responses	0.8	0.9	2.3	-0.6	0.4	-1.5	-1.1	1.0	-0.7
Incentive salience index mean	0.7	0.8	2.1	-0.7	0.2	-1.5	-0.8	1.1	-0.7
Condit. Reinf. lever presses	0.7	0.9	2.2	-0.6	0.3	-1.5	-0.8	1.3	-0.6
Condit. Reinf. active minus inactive responses	3.6	4.7	9.3	-3.0	-1.0	-2.5	-1.8	-0.1	-2.9
Condit. Reinf. active-inactive response ratio	3.8	4.4	8.3	-2.7	-0.4	-2.3	-2.1	-1.1	-2.9
Condit. Reinf. active responses	4.1	5.8	9.8	-3.1	-0.6	-3.1	-2.3	0.1	-3.1
Condit. Reinf. inactive responses	1.0	1.3	2.3	-1.3	-0.6	-1.5	-0.6	1.5	-0.9
Condit. Reinf. lever presses	0.6	0.8	1.7	-0.6	0.7	-1.2	-1.3	-0.3	-1.0
Condit. Reinf. lever reinforcers received	3.7	5.2	8.9	-2.8	-0.2	-3.0	-2.4	-0.1	-2.9
Conditioned reinforcement - actives	0.2	0.4	1.7	-0.5	-0.5	0.3	0.0	-1.3	-0.3
Conditioned reinforcement - inactives	0.8	1.1	2.5	0.2	-1.2	1.3	1.1	-1.6	0.4
Conditioned locomotion	1.5	2.0	4.1	0.4	-1.1	2.0	1.9	-1.3	1.1
Patch foraging indifference point 0 sec	1.3	2.4	4.2	2.1	0.5	2.0	1.3	-1.0	1.9
Patch foraging indifference point AUC	0.3	0.5	1.5	0.5	1.2	-0.5	-0.9	-0.4	-0.1
Delay disc. indifference point, 0s delay	1.2	1.3	2.8	1.4	1.6	0.3	-0.6	-1.7	0.4
Delay disc. indifference point, 16s delay	4.6	5.1	10.3	-1.2	2.1	-2.7	-3.2	-1.2	-2.3
Delay disc. indifference point, 2s delay	1.4	1.6	4.3	2.1	1.2	1.0	0.4	-0.0	1.6
Delay disc. indifference point, 24s delay	1.2	1.3	3.4	0.5	1.8	-1.2	-1.6	0.2	-0.3
Delay disc. indifference point, 4s delay	1.8	1.9	4.8	0.8	2.2	-0.6	-1.7	-1.7	-0.4
Delay disc. indifference point, 8s delay	1.0	1.1	2.6	0.3	1.6	-1.1	-1.5	-0.6	-0.5
Indifference point function ln k	0.3	0.4	1.0	-0.3	-0.9	0.6	0.5	-1.0	-0.3
Indifference point function log k	0.3	0.4	1.0	-0.3	-0.9	0.6	0.5	-1.0	-0.3
Patch foraging total patch changes 0 sec	1.0	2.0	3.9	2.0	0.8	1.6	0.9	-1.1	1.6
Patch foraging total patch changes 12 sec	1.7	2.3	5.9	2.4	1.3	1.5	0.5	-0.6	1.8
Patch foraging total patch changes 18 sec	1.5	2.4	4.7	1.8	0.4	2.2	1.3	-1.3	1.6
Patch foraging total patch changes 24 sec	1.0	1.7	3.6	1.4	0.2	1.9	1.3	-0.9	1.4
Patch foraging total patch changes 6 sec	1.2	1.8	4.5	2.1	1.0	1.3	0.8	-0.2	1.8
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.4	0.1	0.0	-0.1	-0.4	-0.3
Patch foraging water rate 0 sec	0.2	0.4	0.7	0.7	-0.2	0.6	0.8	0.4	0.8
Patch foraging water rate 12 sec	0.5	0.9	2.0	0.0	-1.4	1.2	1.4	0.2	0.5
Patch foraging water rate 18 sec	0.3	0.5	1.7	0.3	-0.3	0.3	0.7	1.3	0.7
Patch foraging water rate 24 sec	0.1	0.1	0.2	0.1	0.4	-0.2	-0.4	-0.1	-0.1
Patch foraging water rate 6 sec	0.9	1.3	2.5	0.6	-1.1	1.1	1.6	1.1	1.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.7	0.6	-0.0	0.8	0.6	-0.6	0.6
Distance traveled before self-admin	0.4	0.5	1.2	1.1	1.0	0.4	-0.2	-0.7	0.5
Distance traveled after self-admin	1.4	1.8	3.5	1.5	-0.3	1.9	1.5	-0.1	1.6
Extensor digitorum longus weight	0.5	2.0	5.3	1.9	2.3	0.4	-0.7	-1.2	0.8
Bone: elastic displacement	0.7	0.8	2.2	-0.9	-1.1	-0.6	0.3	1.5	-0.3
Bone: elastic work	1.1	1.4	2.1	0.9	-0.6	1.0	1.4	1.4	1.4
Bone: endosteal estimation	0.5	1.0	4.0	0.6	1.0	0.6	-0.5	-2.0	-0.1
Bone: endosteal perimeter	0.5	1.1	4.9	0.1	0.8	0.2	-0.7	-2.2	-0.6
Epididymis fat weight	1.3	4.5	9.4	-3.1	-1.2	-2.4	-1.6	-0.4	-2.8
Delta time in closed arm before/after self-admin	0.5	0.5	2.3	0.3	0.3	0.6	-0.0	-1.5	-0.0
Delta time in open arm before/after self-admin	1.1	1.1	3.7	0.9	1.9	-0.7	-1.2	-0.3	0.1
Diff in mean of infusions in LGA sessions	0.3	0.4	0.8	-0.0	-0.8	0.5	0.8	0.9	0.5
Delay discount exponential model param	1.9	2.1	4.6	-0.4	-2.1	1.2	2.0	1.2	0.8
Extinction: sum of active levers before priming	0.2	0.2	0.8	-0.4	-0.4	-0.4	0.1	0.9	-0.1
Active lever presses in extinction session 6	0.2	0.2	0.6	0.6	0.8	-0.3	-0.3	0.4	0.4
Bone: final force	0.3	0.4	0.9	0.8	0.1	1.0	0.6	-0.5	0.7
Bone: final moment	0.3	0.5	0.9	0.8	0.2	0.9	0.4	-0.7	0.6
Food consumed during 24 hour testing period	0.2	0.2	0.6	0.2	0.6	-0.1	-0.5	-0.8	-0.2
Glucose	3.0	4.7	8.2	-2.3	0.4	-2.4	-2.5	-1.5	-2.9
Heart weight	0.1	0.2	0.6	-0.8	-0.2	-0.4	-0.1	0.2	-0.5
Delay discount hyperbolic model param	1.6	1.8	4.3	-0.6	-2.1	1.0	1.8	1.3	0.6
Intermittent access intake day 1-15 change	0.7	1.5	4.4	-1.6	-2.1	0.2	1.1	0.6	-0.5
Intermittent access intake escalation	0.9	1.9	5.5	-1.2	-2.4	0.9	1.7	0.7	0.0
Intermittent access intake escalation 2	1.3	1.5	4.2	-1.0	-2.0	1.1	1.5	-0.3	-0.1
Intermitt. access day 1 inactive lever presses	0.3	1.0	4.3	0.7	0.3	1.0	0.3	-2.1	0.2
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.6	-0.0	-0.7	0.1	0.2	-0.2	-0.0
Intermitt. access escalation Index	0.5	0.7	1.7	1.2	1.3	0.5	-0.3	-0.8	0.5
Intermittent access day 1 total infusions	0.7	1.1	2.1	0.7	-0.8	1.4	1.4	-0.9	1.0
Intermittent access day 15 total infusions	1.9	2.8	6.3	-0.1	-2.2	2.1	2.5	-0.6	0.9
Intermittent access terminal intake (last 3 days)	1.6	2.1	4.6	0.0	-1.8	1.8	2.1	-0.9	0.8
Intermittent access total infusions	1.6	1.9	3.7	0.0	-1.8	1.7	1.9	-1.3	0.6
Intermittent access day 1 locomotion	1.9	2.4	3.9	1.9	0.2	1.9	1.5	-0.9	2.0
Intermittent access day 15 total locomotion	0.9	1.6	3.4	1.0	-0.3	1.9	1.6	-0.9	1.3
Intermittent access total locomotion	1.8	2.2	4.4	0.9	-0.9	2.1	1.8	-1.6	1.2
Intermittent access standard deviation	0.8	1.6	3.5	-1.3	-1.9	0.8	1.0	-1.4	-0.7
Left kidney weight	1.5	6.8	23.1	2.0	4.8	-1.9	-3.1	-0.8	0.1
Right kidney weight	1.4	6.4	21.5	2.4	4.6	-1.8	-2.8	-0.0	0.6
Cocaine induced anxiety	1.0	1.4	3.7	-1.9	-0.8	-1.3	-0.6	0.7	-1.3
Post-drug Anxiety	1.3	1.3	3.1	-1.8	-1.0	-1.0	-0.3	1.3	-1.1
Baseline Anxiety	0.1	0.2	0.4	0.6	0.6	0.1	-0.3	0.2	0.1
Tail length	0.1	0.4	1.5	0.7	1.2	-0.4	-0.7	0.1	0.3
Length with tail	0.4	1.7	5.0	0.8	2.2	-1.0	-1.7	-0.9	-0.2
Length without tail	0.2	0.7	1.8	0.4	1.1	-0.3	-0.8	-1.3	-0.2
Times rat made contact with spout	0.5	0.6	1.6	0.7	-0.3	1.3	0.9	-0.4	0.8
Lifetime Intake	1.3	1.6	2.9	0.3	-1.4	1.6	1.7	-1.3	0.7
Liver weight, left	0.1	0.1	0.2	0.4	0.5	-0.2	-0.3	0.2	0.1
Liver weight, right	0.3	0.5	1.3	1.0	1.2	0.1	-0.5	-0.6	0.5
Locomotor activity	1.3	2.0	3.8	0.5	1.9	-0.8	-1.7	-1.9	-0.6
Locomotor testing distance	1.1	2.1	5.2	0.5	2.0	-0.5	-1.5	-2.3	-0.6
Locomotor testing rearing	0.6	1.1	2.9	1.1	1.7	-0.2	-1.0	-1.3	0.1
Locomotion in novel chamber	1.1	1.4	2.5	1.6	0.0	1.2	1.1	0.8	1.6
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	0.6	0.4	0.1	0.1	0.7	0.5
Fecal boli incidents, locomotor time 1	0.8	1.1	1.9	-1.4	-0.3	-1.4	-0.9	0.8	-1.2
Change in fecal boli incidents, locomotor task	2.0	2.0	4.3	0.7	-1.3	2.1	1.9	-0.8	1.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.7	-0.4	-1.3	0.5	0.9	0.3	0.1
Bouts of movement, locomotor time 1	0.3	0.3	1.0	0.4	0.7	0.2	-0.4	-1.0	-0.1
Total resting periods, locomotor time 1	0.2	0.2	0.9	0.3	0.4	0.3	-0.2	-0.9	-0.1
Rest time, locomotor task time 1	0.6	0.7	1.7	-1.3	-0.8	-0.7	-0.4	-0.2	-1.1
Distance moved, locomotor task time 1	1.3	2.0	4.1	2.0	1.8	1.0	-0.1	-1.5	1.1
Vertical activity count, locomotor time 1	1.0	2.4	4.9	2.2	0.7	1.9	1.3	-0.2	2.0
Time >=10cm from walls, locomotor time 2	1.8	2.7	8.1	-0.8	-2.8	1.5	2.2	0.4	0.4
Bouts of movement, locomotor time 2	0.9	1.5	2.8	0.1	1.7	-0.8	-1.7	-1.3	-0.9
Total resting periods, locomotor time 2	0.9	1.6	3.3	-0.1	1.7	-1.0	-1.8	-1.1	-1.0
Rest time, locomotor task time 2	0.5	0.7	1.1	-1.0	0.1	-1.0	-0.9	-0.2	-1.1
Distance moved, locomotor task time 2	1.4	1.7	4.0	2.0	1.3	1.3	0.2	-1.1	1.3
Vertical activity count, locomotor time 2	0.5	0.7	1.4	1.2	0.5	1.1	0.5	-0.7	0.9
Light reinforcement 1	0.7	1.6	2.9	-0.9	0.8	-1.6	-1.7	-0.9	-1.4
Light reinforcement 2	1.1	1.6	3.9	-2.0	-1.9	-0.5	0.1	0.1	-1.4
Bone: marrow area	0.4	0.9	3.5	0.8	1.0	0.7	-0.3	-1.9	0.1
Bone: maximum diameter	0.2	0.4	1.6	0.3	0.4	0.5	-0.1	-1.3	-0.0
Bone: maximum force	0.6	1.0	1.9	1.4	0.2	1.3	0.9	-0.1	1.3
Bone: maximum moment	0.5	0.9	1.9	1.4	0.4	1.3	0.7	-0.4	1.2
Mean time between licks in bursts	1.1	2.6	6.2	-0.6	-2.5	0.9	2.1	1.8	0.7
Mean num. licks in bursts	0.3	0.5	1.7	-0.6	-1.3	0.5	0.8	0.2	-0.0
Cd content in liver	0.3	0.3	0.7	0.6	0.3	0.6	0.1	-0.9	0.3
Co content in liver	4.1	4.8	11.7	-1.4	-3.4	0.6	2.6	2.8	0.5
Cu content in liver	5.2	6.2	11.6	2.9	-0.0	2.5	2.7	2.0	3.4
Fe content in liver	0.3	0.4	0.6	0.4	-0.5	0.6	0.8	0.5	0.7
K content in liver	0.2	0.2	0.5	-0.4	0.2	-0.7	-0.3	0.5	-0.3
Mg content in liver	0.2	0.2	0.9	-0.0	-0.3	-0.0	0.5	1.0	0.4
Mn content in liver	0.6	0.7	1.3	1.1	0.8	-0.0	0.2	1.1	1.0
Na content in liver	3.5	3.7	7.8	-2.8	-1.3	-2.4	-1.1	1.0	-2.2
Rb content in liver	2.1	2.4	6.9	-1.0	-2.6	1.0	2.1	1.1	0.3
Se content in liver	0.5	0.6	3.1	-0.1	-0.2	-0.6	0.1	1.8	0.3
Sr content in liver	0.7	0.6	1.0	-0.8	0.0	-1.0	-1.0	-0.1	-1.0
Zn content in liver	0.6	0.6	1.2	0.9	0.7	0.8	0.2	-1.1	0.6
Bone: minimum diameter	0.4	0.8	2.8	0.6	0.4	1.0	0.2	-1.7	0.3
Time in familiar zone, hab. session 1	0.5	0.5	1.1	-0.5	-1.1	0.7	0.6	-0.9	-0.2
Time in novel zone, hab. session 1	0.2	0.2	1.1	0.1	-0.2	-0.1	0.3	1.1	0.4
Total zone transitions, hab. session 1	0.4	0.5	0.9	-0.3	0.6	-0.6	-1.0	-1.0	-0.7
Total locomotion distance, hab. session 1	0.5	0.7	1.7	0.4	1.3	-0.6	-1.1	-0.8	-0.3
Locomotion velocity, hab. session 1	0.6	0.8	2.4	0.6	1.6	-0.5	-1.1	-0.8	-0.1
Time in familiar zone, hab. session 2	1.1	1.1	3.8	-0.3	-0.9	1.2	0.8	-1.9	-0.3
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.2	0.7	-0.7	-0.7	0.6	-0.1
Total zone transitions, hab. session 2	0.5	0.7	3.1	0.3	0.2	0.8	0.1	-1.8	-0.0
Total locomotion distance, hab. session 2	1.0	1.3	3.8	1.1	1.4	0.8	-0.4	-2.0	0.3
Locomotion velocity, hab. session 2	0.8	1.0	2.8	1.1	1.1	0.9	-0.1	-1.7	0.4
Novel to familiar place preference ratio	1.3	1.4	3.6	0.0	1.3	-0.4	-1.4	-1.9	-0.8
Novelty place preference	1.0	1.1	3.0	0.2	1.2	-0.3	-1.2	-1.7	-0.6
Time in novel zone, NPP test	1.1	1.2	3.6	-0.2	1.0	-0.4	-1.3	-1.9	-0.9
Total zone transitions, NPP test	0.7	1.0	2.3	-1.5	-0.8	-1.0	-0.6	0.1	-1.3
Total locomotion distance, NPP test	0.3	0.4	1.0	0.8	1.0	0.3	-0.3	-0.7	0.4
Locomotion velocity, NPP test	0.2	0.3	0.7	0.8	0.9	0.2	-0.2	-0.1	0.5
Intraocular pressure	0.2	0.2	0.6	0.5	0.5	0.5	-0.1	-0.8	0.2
Delta distance traveled before/after self-admin	0.8	0.9	2.1	-0.3	-1.4	1.0	1.3	0.3	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	1.0	-0.2	-1.0	0.7	0.9	-0.0	0.4
Parametrial fat weight	2.1	4.9	9.9	-3.1	-0.7	-2.5	-1.9	-0.2	-3.0
Pavlov. Cond. lever latency	0.0	0.1	0.2	0.0	-0.2	0.2	0.2	0.4	0.2
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.3	-0.7	0.3	0.5	0.1	0.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.7	-0.3	-0.6	-0.3	0.1	-0.6
Pavlov. Cond. index score	0.1	0.2	0.4	-0.3	-0.6	0.4	0.5	-0.3	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	-0.5	0.2	0.3	-0.5	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.2	-0.1	0.2	0.4	0.1	0.3
Pavlov. Cond. magazine entry number	0.3	0.3	1.0	0.3	1.0	-0.4	-0.8	-0.3	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.5	1.2	-0.6	0.3	-1.1	-1.0	0.3	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.3	-0.4	0.1	0.3	-0.2	-0.2
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.1	-0.4	0.2	0.4	0.1	0.1
Pavlov. Cond. lever latency	1.1	1.5	3.3	0.1	-1.6	1.5	1.8	0.4	0.8
Pavlov. Cond. magazine entry latency	1.0	1.2	4.4	0.6	0.1	1.4	0.5	-2.1	0.3
Pavlov. Cond. change in total contacts	0.6	1.0	1.9	-0.2	1.2	-1.0	-1.4	-0.9	-0.8
Pavlov. Cond. index score	0.6	0.8	2.2	0.6	1.3	0.0	-0.8	-1.5	-0.1
Pavlov. Cond. latency score	0.5	0.6	1.9	0.7	1.0	0.4	-0.4	-1.4	0.1
Pavlov. Cond. lever contacts	1.3	1.8	3.8	-0.1	1.8	-1.5	-2.0	-0.8	-1.0
Pavlov. Cond. magazine entry number	0.6	0.8	2.3	-0.6	-1.2	-0.2	0.6	1.5	0.0
Pavlov. Cond. intertrial magazine entries	1.9	2.8	5.7	-2.4	-1.3	-2.0	-0.9	1.2	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.7	0.6	1.3	0.0	-0.9	-1.6	-0.2
Pavlov. Cond. response bias	1.1	1.4	2.9	0.1	1.7	-0.8	-1.6	-1.4	-0.7
Time in closed arm before self-admin	1.4	1.8	6.2	0.4	-1.0	0.5	1.3	2.5	1.3
Time in closed arm after self-admin	1.6	1.7	3.5	0.9	-1.0	1.9	1.7	0.2	1.5
Time in open arm before self-admin	0.5	0.6	1.1	-0.9	0.1	-1.1	-0.8	-0.3	-1.0
Time in open arm after self-admin	0.5	0.5	1.4	-0.4	0.6	-1.2	-0.9	0.4	-0.7
Bone: periosteal estimation	0.5	1.1	3.6	1.0	1.0	0.9	-0.2	-1.9	0.3
Bone: periosteal perimeter	0.4	0.6	2.7	0.4	0.7	0.5	-0.3	-1.7	-0.2
Bone: post-yield work	0.3	0.5	1.7	-0.7	-0.5	0.2	-0.2	-1.3	-0.7
Progressive ratio test 1 active lever presses	0.2	0.2	0.5	0.7	-0.1	0.2	0.5	0.0	0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	0.7	-0.2	0.3	0.6	-0.1	0.6
Progressive ratio test 1 inactive lever presses	1.5	2.1	4.5	2.1	1.8	0.9	-0.2	-1.7	1.2
Progressive ratio test 2 active lever presses	1.1	1.3	2.4	0.9	-0.6	1.6	1.5	-0.7	1.2
Progressive ratio test 2 breakpoint	1.3	1.4	2.7	1.0	-0.5	1.6	1.6	-0.7	1.3
Progressive ratio test 2 inactive lever presses	1.7	2.7	5.0	1.5	-0.7	2.2	2.1	-0.8	1.9
Incentive Sensitization - Responses	0.6	0.8	1.5	-0.1	-1.0	1.2	1.1	-1.1	0.4
Incentive Sensitization - Breakpoint	0.7	0.9	1.8	0.1	-0.8	1.3	1.2	-1.0	0.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	-0.4	-0.2	-0.7	-0.3	0.8	-0.3
Progressive ratio	0.7	1.1	2.9	1.7	0.8	1.0	0.4	-0.4	1.2
Food seeking constrained by brief footshock	0.4	0.5	1.0	1.0	0.7	0.5	0.1	-0.8	0.7
Seeking ratio, punishment vs. effort	0.3	0.5	1.4	-1.2	-0.4	-0.7	-0.4	-0.1	-0.9
Retroperitoneal fat weight	3.8	16.4	36.7	-6.1	-2.9	-4.5	-2.5	1.5	-4.9
Reaction time number correct	0.1	0.2	0.7	-0.4	-0.2	0.1	-0.1	-0.9	-0.5
Reaction time mean minus median	1.2	3.1	6.2	-2.2	-0.3	-1.6	-1.7	-1.5	-2.5
Reaction time mean minus median AUC	0.7	1.9	3.8	-1.9	-1.0	-0.9	-0.8	-1.1	-1.9
Reaction time num false alarms	1.1	1.5	4.1	-0.4	-2.0	1.1	1.6	0.9	0.6
Reaction time num false alarms AUC	0.4	0.6	1.4	-0.2	-1.2	0.5	0.9	0.9	0.4
Reaction time trials correct on left	0.1	0.2	0.7	-0.4	-0.2	0.1	-0.1	-0.9	-0.5
Reaction time trials on left	0.1	0.2	0.7	-0.4	-0.2	0.1	-0.1	-0.8	-0.5
Reaction time mean	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.1	-0.2	-0.3
Reaction time mean AUC	0.1	0.2	0.3	-0.6	-0.3	-0.4	-0.3	-0.1	-0.6
Median of all reaction times	0.1	0.1	0.3	0.4	-0.1	0.4	0.4	0.3	0.5
Reaction time omissions	0.3	0.4	1.8	-0.1	-0.5	-0.1	0.4	1.3	0.3
Reaction time false alarm rate	0.5	0.7	1.6	-0.2	-1.3	0.5	1.0	1.1	0.5
Reaction time premature initiation rate	0.7	0.9	1.8	-1.3	-0.6	-0.4	-0.5	-1.2	-1.3
Reaction time premature initiations	0.6	1.0	2.1	-1.3	-0.6	-0.2	-0.4	-1.4	-1.3
Std. dev. reaction times	0.5	0.9	1.8	-1.3	-0.4	-1.0	-0.8	-0.4	-1.3
Reaction time trials completed	0.1	0.2	0.7	-0.4	-0.2	0.1	-0.1	-0.8	-0.5
Reaction time trials AUC	0.1	0.2	0.8	-0.3	-0.3	0.2	0.1	-0.9	-0.3
Run reversals in cocaine runway, females	2.4	2.4	3.8	-1.5	0.8	-1.9	-2.0	-0.9	-1.7
Run reversals in cocaine runway, males	0.7	0.7	3.5	-0.4	-0.5	-0.6	0.2	1.9	0.2
Latency to leave start box in cocaine runway	1.5	1.7	3.7	-1.6	-0.9	-1.3	-0.5	1.9	-1.0
Latency to leave start box in cocaine runway, F	1.1	1.2	2.1	-1.5	-0.6	-1.4	-0.8	1.0	-1.2
Latency to leave start box in cocaine runway, M	0.5	0.5	2.4	-0.4	-0.4	-0.3	0.1	1.6	-0.0
Std. dev. time between licks in bursts	0.2	0.3	1.4	-0.3	-0.3	-0.5	0.1	1.2	0.0
Total sessions with >9 infusions	0.4	0.5	0.8	0.7	-0.3	0.9	0.8	-0.5	0.8
Short access day 1 total inactive lever presses	0.5	0.7	2.4	0.2	-0.4	1.0	0.8	-1.6	0.2
Short access day 10 total inactive lever presses	1.6	3.8	6.9	-2.1	0.1	-1.9	-2.1	-1.8	-2.6
Short access day 1 total infusions	0.5	0.7	2.5	-0.4	-0.8	0.6	0.5	-1.6	-0.3
Short access day 10 total infusions	1.7	2.1	3.8	1.2	-0.7	1.9	1.5	-2.0	1.0
Short access total infusions	0.6	0.8	1.8	0.5	-0.7	1.1	1.0	-1.3	0.5
Short access day 1 locomotion	0.7	0.9	4.7	-0.4	-0.2	0.5	0.0	-2.2	-0.4
Short access day 10 total locomotion	0.3	0.6	1.0	0.8	-0.3	1.0	0.7	-1.0	0.7
Short access total locomotion	0.8	0.9	3.1	0.2	-0.7	1.1	0.8	-1.8	0.3
One hour access (0.3 mA shock)	0.5	0.6	1.1	0.2	-0.7	1.0	1.0	-1.1	0.3
Compulsive drug intake	1.7	2.0	5.4	1.5	2.3	-0.9	-1.8	-0.5	-0.0
One hour access (shock baseline)	2.0	3.0	6.8	-0.6	-2.6	2.0	2.6	-0.0	0.8
Social response proportion	1.5	1.7	5.9	-0.8	-2.4	0.9	1.7	0.3	-0.0
Social responses	0.2	0.2	0.7	-0.1	-0.8	0.0	0.6	0.5	0.2
Social time	0.6	0.8	2.8	-0.7	-1.7	0.2	1.0	0.8	0.0
Soleus weight	1.1	3.4	7.9	2.8	2.6	1.1	-0.1	-1.0	1.8
Bone: stiffness	0.3	0.5	0.9	0.8	0.3	0.9	0.3	-0.7	0.7
Tibialis anterior weight	0.2	0.8	1.6	-0.1	1.0	-0.5	-1.2	-1.3	-0.7
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.9	0.9	0.9	-0.2	-0.4	0.5	0.3
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.9	0.9	0.9	0.6	-0.1	-0.5	0.6
Time to tail flick, test, before self-admin	3.4	3.5	6.1	0.9	-1.6	2.1	2.5	1.8	1.9
Time to tail flick, test, after self-admin	2.1	2.2	6.4	-0.5	-1.8	0.2	1.6	2.5	0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.6	0.3	0.5	0.3	-0.1	-0.8	0.2
Delta time to tail flick, test, before/after SA	2.3	2.3	4.2	-2.0	-0.2	-1.9	-1.3	-0.9	-1.9
Tibia length	0.1	0.4	0.9	-0.6	-0.1	-0.2	-0.5	-1.0	-0.8
Ambulatory time before self-admin	0.2	0.3	0.8	0.8	0.9	-0.2	-0.4	0.6	0.3
Ambulatory time after self-admin	1.5	1.8	3.2	0.8	-1.1	1.6	1.8	1.1	1.5
Bone: tissue strength	0.9	0.9	2.8	-1.4	-1.7	0.1	0.5	-0.0	-0.7
Total heroin consumption	1.3	1.5	4.6	1.4	2.1	-0.2	-1.0	-1.0	0.5
Bone: trabecular number	0.7	1.2	2.3	1.3	0.3	0.7	0.9	1.2	1.5
Bone: trabecular spacing	1.3	1.7	3.0	-1.3	0.1	-1.0	-1.3	-1.6	-1.7
Bone: trabecular thickness	4.1	5.2	8.4	1.9	-1.1	2.5	2.9	1.9	2.9
Bone: trabecular tissue density	1.5	2.3	5.2	2.3	1.2	1.5	1.0	0.2	2.0
Water consumed over 24 hours	0.3	0.4	0.8	0.9	0.4	0.8	0.3	-0.4	0.7
Number of responses in last shaping day	1.8	2.0	4.9	1.1	-0.4	1.9	1.1	-2.2	0.9