Hub : Genes

Cdc5l

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Cdc5l 0.09 0.05 2.1e-07 0.04 0.05 0.04 0.04 4.4e-05 3.6e-06 8.8e-05 8.7e-05
2 IL alternative TSS NM_053527.2 0.25 0.12 1.4e-03 0.1 0.03 0.06 0.06 2.7e-03 6.7e-02 1.7e-02 1.6e-02
3 IC gene expression Cdc5l 0.25 0.12 4.0e-07 0.11 0.18 0.16 0.14 2.0e-05 5.2e-08 3.0e-07 1.3e-06
4 Brain mRNA stability Cdc5l 0.06 0.04 3.3e-04 0.06 0.04 0.06 0.06 2.1e-06 7.0e-05 4.8e-06 4.9e-06
5 IL gene expression Cdc5l 0.43 0.13 3.3e-07 0.21 0.2 0.23 0.21 8.2e-06 1.3e-05 3.5e-06 7.2e-06
6 OFC gene expression Cdc5l 0.2 0.1 2.1e-03 0.16 0.09 0.09 0.13 1.6e-04 4.9e-03 3.6e-03 6.1e-04
7 Adipose gene expression Cdc5l 0.03 0.02 7.0e-04 0.03 0.02 0.02 0.02 2.8e-04 3.4e-03 6.7e-03 4.7e-03
8 Liver mRNA stability Cdc5l 0.04 0.02 1.8e-04 0.02 0.03 0.02 0.03 3.9e-03 3.9e-04 9.8e-04 5.4e-04
9 PL gene expression Cdc5l 0.3 0.11 0.0e+00 0.21 0.21 0.21 0.21 8.0e-23 1.5e-22 3.0e-22 1.1e-22
10 NAcc gene expression Cdc5l 0.12 0.06 4.1e-13 0.11 0.05 0.09 0.04 4.1e-16 5.9e-08 1.1e-13 1.1e-06
11 Brain gene expression Cdc5l 0.15 0.06 3.8e-13 0.15 0.14 0.16 0.16 7.3e-14 1.8e-13 1.9e-14 1.6e-14
12 pVTA gene expression Cdc5l 0.09 0.04 1.1e-06 0.1 0.08 0.1 0 1.3e-08 9.7e-07 4.9e-08 3.2e-01
13 BLA gene expression Cdc5l 0.13 0.06 5.4e-05 0.08 0.06 0.06 0.07 4.9e-05 2.8e-04 5.0e-04 1.1e-04
14 IL alternative TSS XM_063267788.1 0.22 0.11 3.7e-03 0.09 0.02 0.05 0.06 3.6e-03 1.1e-01 2.9e-02 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.42.53.8-1.2-1.81.91.51.81.81.0-0.41.71.71.71.61.61.8
Area under the delay curve1.92.27.42.70.4-0.1-0.6-0.50.32.0-2.4-1.6-1.5-1.5-1.4-1.4-1.2
BMI with tail2.69.014.10.33.3-3.5-2.8-3.5-2.9-3.82.1-2.9-2.9-3.1-3.0-3.0-3.4
BMI without tail2.47.316.8-0.92.5-3.0-2.6-2.9-2.4-4.13.1-2.5-2.4-2.6-2.5-2.5-2.8
Body weight0.83.315.8-2.70.8-1.3-1.6-1.5-1.1-4.03.4-0.7-0.6-0.8-0.7-0.7-1.0
Weight adjusted by age0.10.10.40.10.30.10.2-0.1-0.5-0.6-0.20.30.20.10.20.2-0.0
Bone surface2.85.08.5-0.7-2.42.92.02.62.52.5-2.02.12.02.22.02.02.6
Bone volume2.34.16.6-0.8-2.22.62.02.42.21.9-1.52.02.02.11.91.92.4
Breakpoint value in progressive ratio session0.30.31.11.10.10.20.50.3-0.41.0-1.00.40.40.40.50.50.3
Number of licking bursts0.30.51.6-1.2-0.50.30.40.40.2-0.81.30.70.70.70.70.70.6
Context. condit. distance diff. score1.21.43.6-0.91.4-1.4-1.8-1.6-1.4-1.91.0-0.6-0.7-0.7-0.7-0.7-0.9
Locomotion velocity, session 10.60.62.61.00.5-0.1-0.8-0.5-0.20.9-1.6-0.8-0.8-0.7-0.7-0.7-0.6
Locomotion distance, session 10.30.41.20.31.0-0.7-1.1-0.8-0.60.3-0.7-0.5-0.5-0.5-0.5-0.5-0.5
Locomotion velocity, session 23.03.58.00.12.1-2.0-2.8-2.4-1.5-1.60.5-1.9-1.9-1.9-1.9-1.9-1.9
Locomotion distance, session 20.91.32.30.71.5-1.3-1.5-1.3-0.7-0.1-0.6-1.2-1.2-1.2-1.3-1.3-1.1
Locomotion velocity, session 31.31.52.41.41.2-1.3-1.6-1.4-0.80.0-0.7-1.4-1.3-1.4-1.4-1.4-1.3
Locomotion distance, session 30.40.50.80.80.6-0.6-0.9-0.6-0.30.6-0.9-0.8-0.7-0.8-0.7-0.7-0.5
Stereotopy head waving bouts, day 30.30.41.3-1.1-0.30.70.50.40.6-0.20.30.70.70.60.70.70.4
Stereotopy head waving duration, day 30.20.20.9-0.00.7-0.5-0.3-0.6-0.5-1.00.4-0.2-0.3-0.3-0.3-0.3-0.6
Locomotion velocity, session 70.40.41.70.2-0.30.60.40.50.31.3-1.30.50.50.50.50.50.4
Locomotion distance, session 70.50.61.51.11.0-0.7-0.3-0.7-0.90.6-1.2-0.7-0.8-0.7-0.7-0.7-0.8
Stereotopy head waving bouts, day 70.30.31.8-1.30.2-0.2-0.7-0.4-0.3-1.30.7-0.1-0.1-0.2-0.1-0.1-0.1
Stereotopy head waving duration, day 70.20.21.4-1.2-0.30.3-0.10.20.4-0.70.60.30.30.30.40.40.5
Locomotion velocity, session 80.20.20.9-0.2-0.40.4-0.20.20.20.7-1.00.50.50.50.50.50.5
Locomotion distance, session 81.31.85.20.11.8-1.7-2.3-1.8-1.3-0.7-0.2-1.2-1.2-1.2-1.3-1.3-1.2
Degree of sensitization distance0.30.30.60.40.7-0.4-0.2-0.6-0.8-0.3-0.3-0.4-0.5-0.4-0.4-0.4-0.7
Degree of sensitization stereotypy0.20.30.7-0.60.4-0.3-0.8-0.6-0.5-0.80.1-0.4-0.4-0.5-0.4-0.4-0.2
Conditioned locomotion0.60.73.31.50.10.1-0.3-0.00.21.7-1.8-0.5-0.5-0.4-0.4-0.4-0.4
Cocaine response after cond. corrected0.50.62.5-0.1-0.20.61.60.70.1-0.20.31.01.01.00.90.90.7
Cocaine response after cond. not corrected0.70.83.10.0-0.20.91.70.80.20.1-0.11.11.11.11.11.10.8
Cocaine response before conditioning0.30.32.20.80.10.40.10.1-0.11.1-1.50.10.10.10.20.20.2
Saline control response0.10.20.91.0-0.30.2-0.10.00.20.3-0.9-0.2-0.2-0.1-0.1-0.1-0.1
Bone: connectivity density1.52.34.1-0.8-1.62.01.51.81.81.4-0.71.51.51.51.41.41.7
Bone: cortical apparent density0.30.41.0-1.0-0.80.80.30.60.40.5-0.30.60.50.60.50.50.7
Bone: cortical area0.20.30.8-0.90.10.4-0.30.1-0.40.6-0.70.50.50.60.50.50.8
Bone: cortical porosity0.50.60.90.30.6-0.9-0.9-0.8-0.5-0.40.9-0.8-0.8-0.8-0.9-0.9-0.7
Bone: cortical porosity0.70.81.50.60.8-1.2-0.9-0.9-0.9-0.50.8-1.0-0.9-0.9-1.0-1.0-0.9
Bone: cortical thickness0.30.61.9-0.81.1-0.5-1.4-1.0-1.1-0.1-0.2-0.5-0.5-0.5-0.6-0.6-0.3
Bone: cortical thickness0.50.61.3-1.1-0.90.90.40.80.70.9-0.10.60.70.70.60.61.0
Bone: cortical tissue density0.30.40.9-0.9-0.90.90.40.70.40.5-0.30.60.60.60.60.60.8
Condit. Reinf. active minus inactive responses0.91.01.8-0.3-0.30.71.20.9-0.30.9-0.81.31.41.31.31.31.2
Condit. Reinf. active-inactive response ratio0.91.02.0-0.5-0.70.61.41.0-0.20.20.11.31.31.21.21.21.2
Condit. Reinf. active responses0.40.51.1-0.30.00.40.70.4-0.60.3-0.41.01.01.01.01.00.9
Condit. Reinf. inactive responses0.30.30.8-0.00.8-0.5-0.8-0.8-0.7-0.90.4-0.4-0.4-0.3-0.4-0.4-0.4
Incentive salience index mean0.20.30.50.00.1-0.00.20.2-0.70.6-0.50.70.70.60.60.60.7
Condit. Reinf. lever presses0.50.61.60.40.9-1.1-1.3-1.0-1.1-0.50.3-0.7-0.7-0.7-0.7-0.7-0.5
Condit. Reinf. active minus inactive responses0.10.20.60.20.3-0.10.60.3-0.50.7-0.80.30.30.20.10.10.3
Condit. Reinf. active-inactive response ratio0.20.30.8-0.50.30.10.90.3-0.80.1-0.20.70.70.60.60.60.4
Condit. Reinf. active responses0.30.42.41.00.3-0.10.10.1-0.01.2-1.5-0.4-0.4-0.4-0.4-0.4-0.1
Condit. Reinf. inactive responses0.50.72.41.20.10.0-0.6-0.20.71.2-1.5-0.9-0.9-0.8-0.8-0.8-0.4
Condit. Reinf. lever presses0.20.30.50.40.5-0.7-0.6-0.4-0.40.3-0.5-0.6-0.6-0.6-0.7-0.7-0.2
Condit. Reinf. lever reinforcers received0.30.42.11.00.4-0.2-0.10.0-0.01.1-1.5-0.3-0.3-0.3-0.4-0.4-0.0
Conditioned reinforcement - actives0.30.52.80.41.3-0.7-0.4-0.9-1.7-0.1-0.7-0.2-0.2-0.3-0.3-0.3-0.6
Conditioned reinforcement - inactives0.60.92.00.21.4-1.0-1.0-1.3-1.3-0.2-0.5-0.8-0.8-0.8-0.8-0.8-1.2
Conditioned locomotion0.10.20.4-0.60.10.00.20.0-0.4-0.20.30.60.60.50.50.50.3
Patch foraging indifference point 0 sec0.61.11.8-0.11.0-1.1-0.9-1.1-0.7-1.20.4-1.3-1.3-1.3-1.3-1.3-1.0
Patch foraging indifference point AUC2.33.44.42.12.1-1.9-1.9-1.9-1.80.6-1.6-2.0-2.0-2.0-1.8-1.8-1.7
Delay disc. indifference point, 0s delay1.11.24.62.00.8-0.60.6-0.1-1.41.5-2.1-0.8-0.7-0.7-0.7-0.70.0
Delay disc. indifference point, 16s delay0.80.93.21.7-0.60.80.10.41.41.8-1.5-0.6-0.5-0.6-0.5-0.5-0.3
Delay disc. indifference point, 2s delay1.31.56.02.50.8-0.6-0.1-0.5-0.41.3-1.7-1.3-1.2-1.3-1.2-1.2-1.0
Delay disc. indifference point, 24s delay0.91.02.80.70.5-0.4-1.7-1.00.30.2-0.5-1.3-1.3-1.2-1.3-1.3-1.0
Delay disc. indifference point, 4s delay2.62.78.52.91.2-1.2-0.9-1.1-0.81.4-1.8-2.0-1.7-2.0-1.7-1.7-1.6
Delay disc. indifference point, 8s delay1.21.46.62.0-0.20.6-0.20.10.62.1-2.6-0.8-0.8-0.7-0.8-0.8-0.5
Indifference point function ln k0.20.32.0-0.4-0.2-0.10.60.1-0.1-1.11.4-0.1-0.2-0.0-0.2-0.20.1
Indifference point function log k0.20.32.0-0.4-0.2-0.10.60.1-0.1-1.11.4-0.1-0.2-0.0-0.2-0.20.1
Patch foraging total patch changes 0 sec0.71.42.30.11.1-1.2-1.0-1.3-0.8-1.20.3-1.5-1.5-1.4-1.5-1.5-1.1
Patch foraging total patch changes 12 sec2.53.36.30.41.8-1.8-2.5-2.1-1.3-0.9-0.5-2.2-2.2-2.1-2.0-2.0-1.8
Patch foraging total patch changes 18 sec0.40.61.90.51.0-0.4-0.7-0.7-0.60.2-1.4-0.8-0.8-0.8-0.7-0.7-0.4
Patch foraging total patch changes 24 sec1.72.84.30.71.7-1.7-2.1-1.9-1.0-0.8-0.6-2.1-2.1-2.1-2.0-2.0-1.8
Patch foraging total patch changes 6 sec2.03.04.50.21.7-1.9-2.1-2.0-1.4-1.40.1-2.1-2.1-2.0-2.0-2.0-1.8
Patch foraging time to switch 0 sec3.06.211.4-1.3-3.13.32.02.83.41.6-0.22.62.62.62.52.52.3
Patch foraging water rate 0 sec2.96.113.90.83.1-2.9-2.2-2.8-3.7-1.5-0.6-2.7-2.6-2.5-2.5-2.5-2.0
Patch foraging water rate 12 sec3.47.115.90.33.6-3.5-2.4-3.2-4.0-3.00.8-2.4-2.4-2.3-2.5-2.5-2.0
Patch foraging water rate 18 sec1.62.54.5-0.01.6-1.9-1.3-1.6-1.9-2.11.0-1.7-1.7-1.6-1.7-1.7-1.1
Patch foraging water rate 24 sec2.43.37.1-0.12.0-2.7-1.2-1.7-2.4-2.31.6-1.9-1.8-1.7-1.8-1.8-0.8
Patch foraging water rate 6 sec1.21.73.90.91.8-1.8-1.0-1.4-2.0-0.4-0.5-1.3-1.3-1.2-1.3-1.3-0.7
Seeking ratio, delayed vs. immediate footshock0.00.10.3-0.4-0.6-0.0-0.20.10.2-0.20.30.10.10.20.10.10.3
Distance traveled before self-admin0.50.61.4-1.20.9-0.7-0.8-0.8-0.5-1.21.2-0.5-0.5-0.5-0.6-0.6-0.4
Distance traveled after self-admin0.30.32.10.40.8-0.6-0.3-0.6-1.4-1.00.30.00.0-0.0-0.0-0.0-0.0
Extensor digitorum longus weight0.10.41.5-0.90.6-0.7-0.4-0.6-1.2-1.10.8-0.00.0-0.1-0.0-0.0-0.1
Bone: elastic displacement0.30.30.9-0.6-0.60.70.30.61.00.00.60.60.60.60.50.50.5
Bone: elastic work1.51.94.7-2.2-1.70.90.11.11.6-0.61.91.31.31.31.21.21.5
Bone: endosteal estimation1.94.16.4-0.4-2.52.12.32.52.01.5-0.82.02.02.22.12.12.4
Bone: endosteal perimeter1.12.43.8-0.3-1.71.61.51.81.11.4-1.01.71.71.81.61.61.9
Epididymis fat weight2.37.722.2-2.21.9-2.7-3.0-2.7-1.9-4.74.2-2.3-2.3-2.3-2.4-2.4-2.2
Delta time in closed arm before/after self-admin0.30.31.4-0.5-0.80.40.10.41.2-0.31.0-0.1-0.1-0.0-0.1-0.10.1
Delta time in open arm before/after self-admin2.12.05.32.31.2-1.5-0.8-1.0-1.40.4-1.1-1.6-1.6-1.5-1.7-1.7-1.2
Diff in mean of infusions in LGA sessions0.70.92.6-0.4-0.40.21.60.90.2-0.11.01.21.21.11.21.21.0
Delay discount exponential model param2.12.47.5-2.7-0.40.10.90.6-0.4-1.92.41.71.61.61.61.61.4
Extinction: sum of active levers before priming0.20.21.00.7-0.20.1-0.10.30.01.0-0.80.20.20.20.20.20.4
Active lever presses in extinction session 60.20.21.10.20.5-0.5-0.2-0.4-1.0-0.70.20.20.20.10.20.20.1
Bone: final force0.30.52.8-1.7-0.20.3-0.40.20.10.20.20.70.70.70.60.60.9
Bone: final moment0.20.32.2-1.5-0.00.1-0.50.0-0.00.20.00.50.50.50.40.40.7
Food consumed during 24 hour testing period0.10.10.30.30.5-0.3-0.2-0.4-0.4-0.20.0-0.2-0.2-0.2-0.2-0.2-0.2
Glucose1.32.04.6-0.91.6-1.6-1.2-1.7-2.1-2.11.7-0.9-0.8-0.9-0.9-0.9-1.3
Heart weight0.20.21.9-1.4-0.30.4-0.40.00.5-0.60.80.0-0.00.10.00.00.0
Delay discount hyperbolic model param2.02.36.9-2.6-0.50.10.80.6-0.3-2.02.51.61.51.61.51.51.3
Intermittent access intake day 1-15 change0.91.83.5-0.4-1.01.21.91.41.20.40.31.61.61.61.61.61.4
Intermittent access intake escalation1.53.16.2-0.7-1.31.62.51.81.40.30.52.22.22.12.22.21.7
Intermittent access intake escalation 21.71.92.9-0.1-1.41.61.41.61.71.5-0.71.41.41.51.41.41.3
Intermitt. access day 1 inactive lever presses0.31.03.0-1.2-0.50.10.70.60.3-0.91.71.21.21.11.11.11.0
Intermitt. access day 15 inactive lever presses0.10.20.80.10.9-0.60.4-0.4-0.4-0.20.3-0.3-0.3-0.4-0.3-0.3-0.6
Intermitt. access escalation Index0.20.30.80.70.8-0.90.2-0.5-0.7-0.30.2-0.6-0.5-0.7-0.5-0.5-0.5
Intermittent access day 1 total infusions0.20.31.0-0.00.4-0.7-0.4-0.6-0.2-1.00.5-0.5-0.5-0.5-0.5-0.5-0.7
Intermittent access day 15 total infusions0.71.12.7-0.8-0.50.81.60.90.7-0.60.71.31.31.21.31.30.8
Intermittent access terminal intake (last 3 days)0.30.40.8-0.3-0.40.60.90.50.60.1-0.00.80.80.70.70.70.4
Intermittent access total infusions0.00.00.20.2-0.00.00.5-0.00.2-0.30.00.10.10.10.10.1-0.1
Intermittent access day 1 locomotion0.40.51.3-0.50.4-0.9-1.1-0.8-0.2-1.11.0-0.5-0.5-0.5-0.6-0.6-0.5
Intermittent access day 15 total locomotion0.10.10.5-0.4-0.30.1-0.50.00.7-0.10.30.00.00.2-0.0-0.00.2
Intermittent access total locomotion0.10.10.5-0.5-0.30.1-0.40.10.7-0.20.30.10.00.2-0.0-0.00.3
Intermittent access standard deviation0.51.12.6-0.5-1.41.40.61.11.60.9-0.51.01.01.11.01.01.1
Left kidney weight0.41.64.9-0.51.0-1.5-1.2-1.3-0.6-2.21.7-1.2-1.2-1.1-1.2-1.2-1.0
Right kidney weight1.15.17.10.02.2-2.7-2.2-2.4-2.3-2.61.2-2.5-2.5-2.4-2.5-2.5-2.1
Cocaine induced anxiety0.40.61.5-0.5-0.50.51.20.90.7-0.10.80.90.90.80.90.90.7
Post-drug Anxiety2.62.84.9-1.5-1.91.92.01.92.20.40.61.71.71.71.71.71.6
Baseline Anxiety1.31.63.4-0.8-1.61.80.81.31.61.3-1.11.11.11.21.11.11.1
Tail length0.41.57.4-2.7-0.6-0.0-0.7-0.0-0.2-2.22.50.30.40.30.40.40.6
Length with tail1.67.122.4-4.7-2.71.91.12.01.8-2.03.42.62.72.62.72.72.7
Length without tail1.03.312.8-3.6-1.61.30.41.01.4-1.72.31.81.81.71.81.81.7
Times rat made contact with spout0.30.40.9-0.10.8-0.5-0.5-0.8-0.2-1.00.8-0.6-0.6-0.6-0.5-0.5-0.8
Lifetime Intake0.10.10.60.4-0.10.10.80.20.1-0.1-0.10.20.20.20.20.2-0.0
Liver weight, left1.11.85.30.70.9-1.0-2.3-1.5-0.3-0.7-0.4-1.6-1.7-1.5-1.6-1.6-1.4
Liver weight, right0.30.62.9-1.1-0.5-0.3-1.3-0.20.4-1.21.70.10.10.10.00.00.2
Locomotor activity0.91.56.7-2.6-1.20.6-0.30.60.9-1.11.81.11.11.01.01.01.0
Locomotor testing distance0.61.17.6-2.8-0.80.2-0.80.20.5-1.41.70.60.50.60.50.50.7
Locomotor testing rearing0.30.62.2-1.50.4-1.0-0.6-0.5-1.2-1.51.00.0-0.1-0.1-0.0-0.00.2
Locomotion in novel chamber1.52.03.82.01.3-1.2-1.5-1.3-0.50.6-1.1-1.6-1.5-1.6-1.5-1.5-1.8
Locomotion in novel chamber post-restriction0.61.05.72.2-0.10.3-0.1-0.0-0.41.4-2.4-0.4-0.4-0.3-0.3-0.3-0.2
Fecal boli incidents, locomotor time 10.30.40.90.40.5-0.6-0.8-0.7-0.80.6-0.9-0.5-0.7-0.5-0.7-0.7-0.6
Change in fecal boli incidents, locomotor task0.30.31.31.1-0.40.51.10.60.2-0.1-0.10.40.50.30.50.50.3
Time >=10cm from walls, locomotor time 10.10.10.40.60.2-0.4-0.1-0.2-0.40.1-0.1-0.3-0.2-0.3-0.2-0.2-0.3
Bouts of movement, locomotor time 11.01.11.51.10.9-1.2-1.1-1.2-1.0-0.9-0.1-1.1-1.2-1.0-1.2-1.2-1.1
Total resting periods, locomotor time 10.40.51.10.40.8-0.9-0.6-0.9-1.1-0.90.0-0.6-0.6-0.5-0.6-0.6-0.6
Rest time, locomotor task time 10.81.02.51.21.5-0.7-0.1-0.9-1.60.5-1.3-0.9-0.9-0.8-0.9-0.9-1.0
Distance moved, locomotor task time 10.10.20.7-0.1-0.0-0.5-0.8-0.3-0.0-0.60.8-0.2-0.1-0.3-0.1-0.10.0
Vertical activity count, locomotor time 10.10.20.9-0.1-0.70.2-0.40.31.0-0.40.90.30.40.20.40.40.2
Time >=10cm from walls, locomotor time 20.10.10.3-0.1-0.40.10.50.40.50.30.60.30.40.30.40.40.1
Bouts of movement, locomotor time 20.91.44.10.20.8-1.0-2.0-1.3-0.7-1.0-0.1-1.4-1.5-1.4-1.5-1.5-0.7
Total resting periods, locomotor time 20.61.02.90.30.5-0.9-1.7-1.0-0.4-0.90.1-1.2-1.3-1.2-1.3-1.3-0.6
Rest time, locomotor task time 20.30.41.01.00.8-0.30.0-0.5-0.60.5-0.8-0.6-0.6-0.4-0.6-0.6-0.7
Distance moved, locomotor task time 20.10.10.20.1-0.4-0.20.20.4-0.10.30.20.10.20.10.20.20.4
Vertical activity count, locomotor time 20.71.02.00.1-1.40.90.81.31.11.3-0.21.01.00.91.01.01.0
Light reinforcement 10.20.41.5-0.10.2-0.8-1.2-0.6-0.6-0.80.2-0.8-0.7-0.7-0.7-0.7-0.0
Light reinforcement 20.10.20.9-0.6-0.2-0.3-0.00.20.1-0.71.00.20.30.20.20.20.5
Bone: marrow area1.94.26.6-0.5-2.62.22.32.52.11.6-0.82.12.12.22.12.12.4
Bone: maximum diameter0.20.42.30.4-0.10.50.40.5-0.41.2-1.50.40.40.50.50.50.8
Bone: maximum force0.71.33.5-1.9-1.20.80.21.01.00.20.71.31.31.31.21.21.6
Bone: maximum moment0.50.92.8-1.7-1.00.60.10.80.90.10.71.01.01.10.90.91.4
Mean time between licks in bursts0.61.52.70.1-1.11.71.51.41.51.5-0.81.21.21.11.11.11.0
Mean num. licks in bursts0.50.81.71.30.9-0.6-0.6-0.8-0.30.2-0.9-1.1-1.1-1.1-1.1-1.1-1.1
Cd content in liver0.50.62.30.9-0.70.31.50.90.50.6-0.20.60.60.60.60.60.7
Co content in liver0.20.21.50.6-0.1-0.4-0.10.00.9-0.31.2-0.2-0.1-0.2-0.1-0.1-0.2
Cu content in liver0.20.31.71.30.2-0.3-0.2-0.0-0.20.7-1.0-0.4-0.4-0.3-0.4-0.4-0.2
Fe content in liver1.21.42.60.31.3-1.2-1.6-1.4-0.6-0.2-0.2-1.4-1.4-1.5-1.4-1.4-1.4
K content in liver3.02.85.6-1.9-2.41.60.81.92.20.41.01.61.71.61.71.71.9
Mg content in liver0.20.21.1-0.8-0.30.0-1.0-0.10.6-0.20.2-0.4-0.3-0.3-0.3-0.3-0.1
Mn content in liver0.10.20.70.1-0.50.50.90.60.40.20.10.20.20.20.20.20.4
Na content in liver0.40.41.2-1.10.2-0.4-1.0-0.7-0.4-1.10.8-0.3-0.3-0.3-0.3-0.3-0.5
Rb content in liver1.61.94.10.1-1.81.71.01.62.02.0-1.30.91.01.11.01.01.4
Se content in liver2.02.43.41.01.6-1.1-1.8-1.6-1.4-0.1-1.2-1.8-1.8-1.8-1.8-1.8-1.8
Sr content in liver0.50.40.7-0.7-0.40.20.80.70.0-0.20.70.80.80.80.80.80.8
Zn content in liver0.50.51.50.60.5-0.5-1.2-0.7-0.40.4-1.1-0.8-0.7-0.8-0.7-0.7-0.6
Bone: minimum diameter1.32.43.7-0.9-1.41.81.31.61.01.5-1.01.81.81.81.71.71.9
Time in familiar zone, hab. session 13.83.74.80.91.8-1.9-2.1-2.2-1.8-1.90.6-2.1-2.1-2.1-2.2-2.2-2.1
Time in novel zone, hab. session 12.32.34.3-0.2-1.41.32.11.81.71.5-0.51.61.61.61.71.71.6
Total zone transitions, hab. session 10.81.12.40.11.4-1.5-1.3-1.3-1.0-1.00.4-0.9-0.9-1.0-0.9-0.9-1.1
Total locomotion distance, hab. session 10.81.22.9-0.11.7-1.5-1.0-1.4-1.6-1.30.4-0.7-0.7-0.9-0.7-0.7-1.1
Locomotion velocity, hab. session 10.60.82.5-0.41.6-1.2-0.9-1.2-1.6-1.20.3-0.3-0.3-0.5-0.3-0.3-0.8
Time in familiar zone, hab. session 20.40.41.2-0.7-1.10.80.30.60.9-0.40.90.50.50.50.50.50.4
Time in novel zone, hab. session 21.01.02.80.71.7-1.3-0.6-1.1-1.2-0.2-0.6-1.0-1.0-1.0-1.0-1.0-0.9
Total zone transitions, hab. session 20.30.41.4-1.2-0.20.30.50.40.2-0.30.70.70.70.60.80.80.7
Total locomotion distance, hab. session 20.10.20.8-0.80.4-0.20.1-0.2-0.5-0.90.60.30.30.20.30.30.1
Locomotion velocity, hab. session 20.10.20.6-0.8-0.00.20.40.2-0.2-0.50.40.50.50.40.60.60.3
Novel to familiar place preference ratio0.10.10.2-0.4-0.10.00.30.1-0.2-0.40.40.10.10.20.20.20.2
Novelty place preference0.10.10.4-0.6-0.20.0-0.00.0-0.0-0.50.50.00.10.10.20.20.1
Time in novel zone, NPP test0.10.10.4-0.40.2-0.3-0.2-0.3-0.3-0.60.4-0.3-0.3-0.3-0.2-0.2-0.2
Total zone transitions, NPP test0.40.61.7-0.71.1-0.9-1.3-1.0-0.8-0.70.2-0.6-0.6-0.7-0.6-0.6-0.6
Total locomotion distance, NPP test0.40.51.1-0.81.1-0.9-1.0-0.8-1.1-0.80.3-0.3-0.3-0.4-0.3-0.3-0.3
Locomotion velocity, NPP test0.30.43.0-1.70.3-0.2-0.7-0.2-0.4-0.70.70.40.40.30.40.40.4
Intraocular pressure0.40.63.10.6-0.00.01.70.6-0.4-0.40.80.80.80.70.80.80.4
Delta distance traveled before/after self-admin0.30.31.01.00.00.00.60.2-1.0-0.4-0.20.70.70.60.70.70.5
Delta ambulatory time before/after self-admin0.60.71.40.8-0.40.50.90.7-0.4-0.2-0.11.21.21.11.21.20.9
Parametrial fat weight2.04.714.5-1.01.9-2.8-2.0-2.2-1.8-3.83.4-1.6-1.6-1.7-1.6-1.6-1.6
Pavlov. Cond. lever latency0.70.82.9-0.2-0.80.81.71.20.80.40.30.90.90.91.01.01.0
Pavlov. Cond. magazine entry latency0.30.41.30.90.6-0.6-0.4-0.5-0.70.3-1.2-0.5-0.5-0.6-0.6-0.6-0.5
Pavlov. Cond. change in total contacts0.70.71.10.80.9-1.0-0.9-1.0-1.0-0.5-0.4-0.8-0.8-0.9-0.9-0.9-0.9
Pavlov. Cond. index score0.60.81.60.50.9-0.9-1.3-1.1-1.1-0.3-0.7-0.8-0.8-0.9-0.9-0.9-0.9
Pavlov. Cond. latency score0.50.71.70.50.7-0.7-1.3-0.9-0.70.1-1.0-0.7-0.7-0.8-0.8-0.8-0.8
Pavlov. Cond. lever contacts1.01.23.10.41.0-1.2-1.8-1.4-0.9-0.70.0-1.1-1.1-1.1-1.2-1.2-1.2
Pavlov. Cond. magazine entry number0.40.61.4-0.7-0.90.90.60.91.20.40.70.60.50.70.70.70.8
Pavlov. Cond. intertrial magazine entries0.10.10.30.20.1-0.1-0.5-0.20.30.20.3-0.3-0.3-0.2-0.3-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.60.81.40.70.9-1.0-1.1-1.1-1.2-0.4-0.6-0.8-0.8-0.9-0.9-0.9-0.9
Pavlov. Cond. response bias0.70.91.40.51.0-1.1-1.1-1.2-1.2-0.9-0.2-0.8-0.8-0.9-0.9-0.9-1.0
Pavlov. Cond. lever latency0.10.10.91.0-0.10.10.3-0.0-0.00.2-0.2-0.3-0.3-0.3-0.3-0.3-0.4
Pavlov. Cond. magazine entry latency0.30.31.1-1.00.9-0.6-1.0-0.7-0.4-0.40.5-0.1-0.1-0.1-0.1-0.1-0.1
Pavlov. Cond. change in total contacts0.20.31.6-1.20.5-0.4-0.7-0.5-0.2-0.70.7-0.1-0.1-0.1-0.2-0.2-0.1
Pavlov. Cond. index score0.40.51.6-1.21.0-0.8-1.3-0.9-0.4-0.60.5-0.3-0.3-0.3-0.4-0.4-0.2
Pavlov. Cond. latency score0.40.61.7-1.11.0-0.9-1.3-1.0-0.5-0.70.6-0.4-0.4-0.4-0.4-0.4-0.3
Pavlov. Cond. lever contacts0.10.21.3-1.10.1-0.2-0.5-0.10.0-0.30.40.20.20.20.10.10.4
Pavlov. Cond. magazine entry number0.20.21.51.2-0.40.21.00.4-0.1-0.0-0.1-0.1-0.1-0.1-0.0-0.0-0.1
Pavlov. Cond. intertrial magazine entries0.10.20.6-0.0-0.80.60.80.50.3-0.40.10.30.30.30.30.30.2
Pavlov. Cond. lever-magazine prob. diff.0.40.61.8-1.21.0-0.8-1.3-1.0-0.4-0.80.7-0.4-0.4-0.4-0.4-0.4-0.4
Pavlov. Cond. response bias0.20.31.8-1.3-0.10.4-0.30.20.40.3-0.10.50.50.60.50.50.7
Time in closed arm before self-admin0.30.41.4-1.0-0.10.11.20.6-0.4-0.30.70.70.70.60.70.70.5
Time in closed arm after self-admin0.80.85.0-1.10.6-0.81.20.0-0.6-1.52.20.10.10.10.20.20.0
Time in open arm before self-admin0.20.21.1-0.3-0.00.2-1.0-0.60.2-0.80.20.10.1-0.10.10.1-0.4
Time in open arm after self-admin0.80.83.21.80.5-0.7-1.1-0.9-0.40.1-0.7-0.8-0.8-0.9-0.9-0.9-1.0
Bone: periosteal estimation0.91.93.7-0.5-1.41.41.31.60.81.5-1.11.41.51.61.51.51.9
Bone: periosteal perimeter0.71.22.9-1.3-1.10.90.31.00.40.4-0.11.31.31.41.21.21.7
Bone: post-yield work0.40.61.7-1.1-1.20.20.20.81.0-0.41.30.50.50.60.40.41.0
Progressive ratio test 1 active lever presses0.40.52.3-1.0-0.3-0.11.10.4-0.1-1.11.50.60.60.60.60.60.4
Progressive ratio test 1 breakpoint0.50.62.3-0.9-0.40.01.10.50.0-1.01.50.70.70.70.70.70.5
Progressive ratio test 1 inactive lever presses0.20.31.1-0.90.4-0.5-0.1-0.4-0.3-1.11.0-0.0-0.1-0.1-0.1-0.1-0.2
Progressive ratio test 2 active lever presses0.60.63.4-0.60.6-0.70.5-0.4-1.0-1.81.60.30.30.20.30.3-0.2
Progressive ratio test 2 breakpoint0.60.74.0-0.80.6-0.80.5-0.4-1.0-2.01.80.30.30.20.30.3-0.3
Progressive ratio test 2 inactive lever presses0.30.51.20.11.0-0.8-0.2-0.9-1.1-0.90.3-0.4-0.4-0.5-0.5-0.5-0.8
Incentive Sensitization - Responses1.11.64.5-0.11.5-1.6-1.0-1.5-1.5-2.11.4-0.9-0.9-0.9-0.9-0.9-1.3
Incentive Sensitization - Breakpoint1.21.64.1-0.11.6-1.6-1.0-1.6-1.5-2.01.3-0.9-0.9-0.9-0.9-0.9-1.4
Sum of active levers in priming session hrs 5-61.41.38.12.50.30.4-0.4-0.2-0.21.7-2.8-0.5-0.5-0.5-0.4-0.4-0.2
Progressive ratio1.52.44.2-1.9-2.02.00.61.52.11.0-0.31.61.61.51.51.51.6
Food seeking constrained by brief footshock3.03.65.4-1.6-2.22.01.71.92.00.20.32.22.32.12.22.22.0
Seeking ratio, punishment vs. effort0.10.10.70.60.3-0.40.5-0.0-0.8-0.4-0.10.10.10.10.20.2-0.0
Retroperitoneal fat weight2.510.717.2-0.43.4-3.8-3.8-3.8-3.1-4.12.5-3.3-3.3-3.3-3.3-3.3-3.0
Reaction time number correct1.93.75.42.02.0-1.7-1.6-1.9-2.30.4-2.2-2.1-2.1-2.1-2.0-2.0-1.7
Reaction time mean minus median0.71.83.9-2.0-1.11.51.31.31.10.60.51.51.51.41.51.51.1
Reaction time mean minus median AUC1.12.73.7-1.9-1.61.71.91.81.41.00.41.71.81.81.81.81.7
Reaction time num false alarms0.40.61.00.90.6-0.4-0.8-0.7-0.10.3-0.9-1.0-0.9-0.9-1.0-1.0-0.9
Reaction time num false alarms AUC0.61.01.61.10.7-0.7-1.0-0.9-0.20.2-0.7-1.2-1.2-1.1-1.3-1.3-1.2
Reaction time trials correct on left1.93.75.42.02.0-1.7-1.6-1.9-2.30.4-2.2-2.1-2.1-2.1-2.0-2.0-1.7
Reaction time trials on left2.03.75.52.02.1-1.7-1.6-1.9-2.40.3-2.1-2.1-2.1-2.1-2.1-2.1-1.7
Reaction time mean1.82.85.3-2.3-1.61.41.41.51.8-0.62.21.71.81.71.71.71.4
Reaction time mean AUC1.82.95.8-2.4-1.61.41.41.51.7-0.52.01.81.81.81.71.71.5
Median of all reaction times1.52.25.3-2.0-1.51.11.01.21.6-1.02.31.51.51.51.41.41.2
Reaction time omissions0.20.31.5-1.20.00.1-0.7-0.4-0.3-1.00.90.10.10.00.00.0-0.2
Reaction time false alarm rate0.10.10.90.0-0.40.30.10.21.00.10.30.10.10.1-0.0-0.0-0.1
Reaction time premature initiation rate0.20.20.50.0-0.0-0.5-0.7-0.30.50.00.4-0.4-0.5-0.5-0.6-0.6-0.4
Reaction time premature initiations0.71.32.20.70.9-1.3-1.4-1.1-0.70.1-0.5-1.3-1.4-1.3-1.5-1.5-1.1
Std. dev. reaction times1.42.76.1-2.5-1.61.51.31.51.5-0.11.61.81.81.71.81.81.4
Reaction time trials completed2.03.75.52.02.1-1.7-1.6-1.9-2.40.3-2.1-2.1-2.1-2.1-2.1-2.1-1.7
Reaction time trials AUC2.03.86.21.92.1-1.8-1.7-2.0-2.50.1-2.0-2.1-2.1-2.1-2.1-2.1-1.7
Run reversals in cocaine runway, females1.01.01.9-0.7-0.80.80.40.90.00.8-0.21.31.41.31.41.41.4
Run reversals in cocaine runway, males0.50.51.00.10.9-1.0-0.4-0.7-0.7-0.60.2-0.9-0.9-0.8-0.9-0.9-0.6
Latency to leave start box in cocaine runway1.31.55.4-1.4-1.0-0.21.01.00.4-1.22.31.11.11.21.11.11.5
Latency to leave start box in cocaine runway, F0.30.41.3-0.8-0.6-0.40.40.60.0-0.51.20.40.40.60.40.41.0
Latency to leave start box in cocaine runway, M1.21.15.9-1.2-0.3-0.40.70.40.2-1.62.40.90.90.80.90.90.8
Std. dev. time between licks in bursts0.40.51.71.1-0.60.50.70.80.61.3-0.80.40.40.40.40.40.6
Total sessions with >9 infusions0.10.11.20.40.0-0.11.10.3-0.10.6-0.30.10.10.10.10.10.0
Short access day 1 total inactive lever presses0.20.30.70.40.4-0.9-0.7-0.6-0.4-0.20.6-0.4-0.4-0.5-0.5-0.5-0.6
Short access day 10 total inactive lever presses0.82.04.70.51.7-1.5-2.2-1.8-0.90.1-0.1-1.5-1.5-1.5-1.6-1.6-1.7
Short access day 1 total infusions0.70.92.01.11.0-1.4-0.2-0.8-1.3-0.10.1-1.0-1.0-1.0-1.0-1.0-0.9
Short access day 10 total infusions0.20.20.70.4-0.50.50.80.50.50.5-0.20.50.50.50.50.50.3
Short access total infusions0.10.20.80.9-0.1-0.10.90.3-0.10.7-0.60.00.00.00.00.0-0.1
Short access day 1 locomotion0.10.10.60.5-0.0-0.20.50.20.10.8-0.20.00.00.1-0.0-0.0-0.0
Short access day 10 total locomotion0.00.10.4-0.1-0.30.3-0.40.10.60.2-0.00.20.20.20.20.20.3
Short access total locomotion0.10.10.70.1-0.30.10.20.30.40.8-0.40.10.10.20.10.10.3
One hour access (0.3 mA shock)0.30.30.91.00.8-0.7-0.1-0.7-0.8-0.5-0.4-0.3-0.3-0.4-0.4-0.4-0.7
Compulsive drug intake1.01.22.61.60.9-1.2-1.0-0.9-0.50.5-0.7-1.3-1.3-1.3-1.3-1.3-0.9
One hour access (shock baseline)0.20.41.3-0.6-0.00.20.80.1-0.5-1.20.50.70.70.70.70.70.2
Social response proportion0.20.20.70.1-0.70.9-0.20.20.40.3-0.40.50.50.40.50.50.1
Social responses0.30.41.9-0.2-1.20.8-0.70.41.40.3-0.10.40.40.50.50.50.5
Social time2.83.85.32.31.7-1.8-2.2-1.9-1.60.0-1.5-2.2-2.2-2.1-2.2-2.2-2.0
Soleus weight0.00.10.5-0.4-0.1-0.7-0.7-0.2-0.4-0.30.6-0.00.10.00.00.00.1
Bone: stiffness0.00.00.3-0.5-0.1-0.1-0.4-0.10.10.00.10.00.00.10.00.00.2
Tibialis anterior weight0.51.85.5-0.11.8-1.8-1.4-1.7-2.3-1.20.4-1.1-1.1-1.2-1.1-1.1-1.1
Time to tail flick, vehicle, before self-admin0.30.31.2-1.1-0.50.7-0.20.30.50.8-0.90.20.20.20.10.10.4
Time to tail flick, vehicle, after self-admin1.11.53.2-0.7-1.51.40.81.51.81.5-0.31.11.11.11.21.21.4
Time to tail flick, test, before self-admin2.32.311.53.41.1-0.30.8-0.3-1.62.1-2.9-0.6-0.6-0.8-0.6-0.6-1.2
Time to tail flick, test, after self-admin0.30.41.10.51.0-0.9-0.2-0.4-1.10.5-0.6-0.5-0.5-0.5-0.4-0.4-0.3
Delta time to tail flick, vehicle, before/after SA0.10.10.50.70.00.10.10.20.20.7-0.30.20.20.10.20.20.1
Delta time to tail flick, test, before/after SA1.01.15.4-2.1-0.0-0.6-1.0-0.30.3-1.82.3-0.1-0.1-0.0-0.0-0.00.4
Tibia length1.02.85.61.42.1-2.1-1.6-1.9-2.4-0.6-0.6-1.7-1.7-1.6-1.7-1.7-1.5
Ambulatory time before self-admin1.42.13.6-0.61.9-1.6-1.6-1.8-1.2-1.51.1-1.4-1.4-1.5-1.5-1.5-1.4
Ambulatory time after self-admin0.80.94.3-0.31.5-1.0-0.8-1.1-2.1-1.50.6-0.2-0.2-0.3-0.2-0.2-0.4
Bone: tissue strength0.70.71.90.20.5-1.0-1.4-0.9-0.2-0.50.5-0.9-0.9-0.9-1.0-1.0-0.8
Total heroin consumption0.30.41.1-0.5-0.70.4-0.10.50.4-0.30.40.70.70.70.80.81.0
Bone: trabecular number1.11.83.7-1.3-1.01.91.01.31.01.1-1.01.51.51.41.31.31.5
Bone: trabecular spacing2.22.94.51.31.8-1.8-1.9-2.0-1.3-0.50.1-2.0-2.0-2.0-1.9-1.9-2.1
Bone: trabecular thickness4.35.37.5-1.0-2.52.72.42.62.01.9-1.42.52.52.42.52.52.7
Bone: trabecular tissue density4.16.09.83.12.9-2.6-1.5-2.4-3.00.3-2.1-2.6-2.6-2.6-2.6-2.6-2.4
Water consumed over 24 hours1.72.34.00.21.8-1.4-2.0-2.0-1.4-1.40.2-1.6-1.6-1.6-1.6-1.6-1.5
Number of responses in last shaping day0.50.52.50.50.8-1.10.3-0.5-1.6-1.10.6-0.3-0.3-0.3-0.3-0.3-0.3