Hub : Genes

Ccnyl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ccnyl1 0.02 0.02 7.6e-03 0.01 0.01 0 0.01 3.5e-02 3.3e-02 1.2e-01 4.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.10.20.2-0.4
Area under the delay curve0.10.10.10.3
BMI with tail8.728.128.15.3
BMI without tail3.98.08.02.8
Body weight0.41.61.61.3
Weight adjusted by age0.20.20.2-0.5
Bone surface0.40.70.7-0.8
Bone volume0.91.61.6-1.2
Breakpoint value in progressive ratio session1.31.41.4-1.2
Number of licking bursts0.20.20.20.5
Context. condit. distance diff. score1.11.31.31.2
Locomotion velocity, session 11.51.61.6-1.3
Locomotion distance, session 10.10.20.2-0.4
Locomotion velocity, session 20.10.10.1-0.3
Locomotion distance, session 20.00.00.00.1
Locomotion velocity, session 30.60.70.70.8
Locomotion distance, session 31.61.71.7-1.3
Stereotopy head waving bouts, day 32.32.72.71.6
Stereotopy head waving duration, day 32.73.23.21.8
Locomotion velocity, session 70.00.00.00.2
Locomotion distance, session 70.30.40.4-0.7
Stereotopy head waving bouts, day 70.50.50.50.7
Stereotopy head waving duration, day 72.22.72.71.6
Locomotion velocity, session 80.10.10.10.4
Locomotion distance, session 80.20.30.30.6
Degree of sensitization distance0.40.40.40.7
Degree of sensitization stereotypy0.70.80.80.9
Conditioned locomotion1.31.61.6-1.3
Cocaine response after cond. corrected1.31.41.4-1.2
Cocaine response after cond. not corrected1.61.71.7-1.3
Cocaine response before conditioning0.00.00.00.1
Saline control response0.70.90.90.9
Bone: connectivity density0.40.60.60.8
Bone: cortical apparent density2.43.23.21.8
Bone: cortical area0.91.41.4-1.2
Bone: cortical porosity8.08.88.8-3.0
Bone: cortical porosity9.410.310.3-3.2
Bone: cortical thickness0.20.30.3-0.5
Bone: cortical thickness2.42.82.8-1.7
Bone: cortical tissue density2.93.83.81.9
Condit. Reinf. active minus inactive responses1.11.21.2-1.1
Condit. Reinf. active-inactive response ratio0.00.00.0-0.2
Condit. Reinf. active responses2.02.42.4-1.6
Condit. Reinf. inactive responses1.51.81.8-1.3
Incentive salience index mean1.51.81.8-1.4
Condit. Reinf. lever presses1.31.81.8-1.3
Condit. Reinf. active minus inactive responses8.710.810.8-3.3
Condit. Reinf. active-inactive response ratio7.57.87.8-2.8
Condit. Reinf. active responses5.78.08.0-2.8
Condit. Reinf. inactive responses0.30.40.4-0.6
Condit. Reinf. lever presses1.01.41.4-1.2
Condit. Reinf. lever reinforcers received6.08.48.4-2.9
Conditioned reinforcement - actives0.40.40.40.6
Conditioned reinforcement - inactives2.02.22.2-1.5
Conditioned locomotion4.85.85.82.4
Patch foraging indifference point 0 sec1.01.71.71.3
Patch foraging indifference point AUC0.91.01.0-1.0
Delay disc. indifference point, 0s delay1.41.51.51.2
Delay disc. indifference point, 16s delay0.00.00.0-0.2
Delay disc. indifference point, 2s delay1.71.91.91.4
Delay disc. indifference point, 24s delay0.20.20.20.4
Delay disc. indifference point, 4s delay1.31.31.31.2
Delay disc. indifference point, 8s delay0.00.00.0-0.1
Indifference point function ln k2.73.73.71.9
Indifference point function log k2.73.73.71.9
Patch foraging total patch changes 0 sec1.01.61.61.2
Patch foraging total patch changes 12 sec0.10.20.2-0.4
Patch foraging total patch changes 18 sec0.40.50.50.7
Patch foraging total patch changes 24 sec0.00.00.0-0.1
Patch foraging total patch changes 6 sec0.71.11.11.0
Patch foraging time to switch 0 sec0.00.00.0-0.1
Patch foraging water rate 0 sec0.10.10.10.3
Patch foraging water rate 12 sec0.60.80.80.9
Patch foraging water rate 18 sec0.20.30.3-0.5
Patch foraging water rate 24 sec0.10.10.10.4
Patch foraging water rate 6 sec1.62.32.31.5
Seeking ratio, delayed vs. immediate footshock0.91.11.1-1.0
Distance traveled before self-admin4.44.74.7-2.2
Distance traveled after self-admin0.00.00.0-0.0
Extensor digitorum longus weight1.97.37.32.7
Bone: elastic displacement0.20.20.20.4
Bone: elastic work0.30.40.4-0.7
Bone: endosteal estimation1.73.73.7-1.9
Bone: endosteal perimeter0.50.90.9-1.0
Epididymis fat weight0.00.00.0-0.1
Delta time in closed arm before/after self-admin0.90.90.91.0
Delta time in open arm before/after self-admin3.93.83.8-1.9
Diff in mean of infusions in LGA sessions0.40.40.40.6
Delay discount exponential model param0.10.10.1-0.2
Extinction: sum of active levers before priming0.00.00.00.1
Active lever presses in extinction session 60.50.50.5-0.7
Bone: final force1.52.42.4-1.5
Bone: final moment0.91.41.4-1.2
Food consumed during 24 hour testing period0.70.80.8-0.9
Glucose0.81.21.21.1
Heart weight0.00.00.0-0.1
Delay discount hyperbolic model param0.20.20.2-0.4
Intermittent access intake day 1-15 change0.10.10.10.2
Intermittent access intake escalation0.00.00.00.1
Intermittent access intake escalation 20.00.00.0-0.2
Intermitt. access day 1 inactive lever presses0.00.00.0-0.2
Intermitt. access day 15 inactive lever presses0.70.80.8-0.9
Intermitt. access escalation Index1.10.90.91.0
Intermittent access day 1 total infusions0.00.00.00.0
Intermittent access day 15 total infusions0.20.30.30.5
Intermittent access terminal intake (last 3 days)0.60.70.70.8
Intermittent access total infusions0.00.00.00.0
Intermittent access day 1 locomotion0.00.00.00.0
Intermittent access day 15 total locomotion0.00.00.00.0
Intermittent access total locomotion0.20.20.20.5
Intermittent access standard deviation0.60.70.7-0.8
Left kidney weight0.10.20.20.5
Right kidney weight0.00.10.10.3
Cocaine induced anxiety1.01.11.11.1
Post-drug Anxiety1.01.11.11.1
Baseline Anxiety0.50.50.5-0.7
Tail length5.316.016.0-4.0
Length with tail5.419.919.9-4.5
Length without tail1.22.52.5-1.6
Times rat made contact with spout0.91.01.0-1.0
Lifetime Intake0.20.20.20.5
Liver weight, left2.03.33.3-1.8
Liver weight, right0.91.41.4-1.2
Locomotor activity0.00.00.00.1
Locomotor testing distance0.20.30.30.5
Locomotor testing rearing0.00.00.00.2
Locomotion in novel chamber1.11.31.31.1
Locomotion in novel chamber post-restriction0.00.00.00.0
Fecal boli incidents, locomotor time 11.51.61.6-1.3
Change in fecal boli incidents, locomotor task0.10.10.1-0.3
Time >=10cm from walls, locomotor time 12.82.82.8-1.7
Bouts of movement, locomotor time 11.92.12.1-1.4
Total resting periods, locomotor time 11.41.51.5-1.2
Rest time, locomotor task time 11.92.12.1-1.5
Distance moved, locomotor task time 10.70.80.80.9
Vertical activity count, locomotor time 11.41.41.41.2
Time >=10cm from walls, locomotor time 20.80.90.9-0.9
Bouts of movement, locomotor time 20.50.50.50.7
Total resting periods, locomotor time 20.10.10.10.2
Rest time, locomotor task time 21.82.12.1-1.4
Distance moved, locomotor task time 20.91.01.01.0
Vertical activity count, locomotor time 24.34.74.72.2
Light reinforcement 11.62.92.91.7
Light reinforcement 20.71.01.0-1.0
Bone: marrow area1.73.63.6-1.9
Bone: maximum diameter1.22.12.1-1.5
Bone: maximum force0.71.21.2-1.1
Bone: maximum moment0.30.50.5-0.7
Mean time between licks in bursts0.40.60.60.8
Mean num. licks in bursts0.50.60.6-0.7
Cd content in liver0.40.40.40.7
Co content in liver0.20.30.30.5
Cu content in liver0.00.00.0-0.0
Fe content in liver0.10.10.1-0.3
K content in liver0.10.10.10.2
Mg content in liver0.50.50.50.7
Mn content in liver2.42.72.71.6
Na content in liver0.70.70.7-0.8
Rb content in liver0.00.00.00.0
Se content in liver0.60.80.80.9
Sr content in liver0.10.10.1-0.3
Zn content in liver0.30.30.30.6
Bone: minimum diameter1.62.92.9-1.7
Time in familiar zone, hab. session 12.32.22.21.5
Time in novel zone, hab. session 16.96.76.7-2.6
Total zone transitions, hab. session 10.60.90.9-0.9
Total locomotion distance, hab. session 12.12.92.9-1.7
Locomotion velocity, hab. session 11.62.32.3-1.5
Time in familiar zone, hab. session 20.20.20.20.4
Time in novel zone, hab. session 20.00.00.0-0.1
Total zone transitions, hab. session 20.00.00.0-0.1
Total locomotion distance, hab. session 20.00.10.1-0.2
Locomotion velocity, hab. session 20.00.10.1-0.2
Novel to familiar place preference ratio1.41.41.4-1.2
Novelty place preference1.81.81.8-1.4
Time in novel zone, NPP test2.12.12.1-1.5
Total zone transitions, NPP test0.20.30.3-0.5
Total locomotion distance, NPP test0.60.80.8-0.9
Locomotion velocity, NPP test0.20.40.4-0.6
Intraocular pressure3.04.24.22.0
Delta distance traveled before/after self-admin2.83.03.01.7
Delta ambulatory time before/after self-admin2.42.72.71.6
Parametrial fat weight0.30.60.6-0.8
Pavlov. Cond. lever latency0.00.10.10.2
Pavlov. Cond. magazine entry latency0.50.70.7-0.8
Pavlov. Cond. change in total contacts0.00.10.10.2
Pavlov. Cond. index score0.50.60.6-0.8
Pavlov. Cond. latency score0.40.50.5-0.7
Pavlov. Cond. lever contacts0.20.20.2-0.4
Pavlov. Cond. magazine entry number0.30.40.40.6
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.0
Pavlov. Cond. lever-magazine prob. diff.0.50.70.7-0.8
Pavlov. Cond. response bias0.60.70.7-0.9
Pavlov. Cond. lever latency1.31.71.71.3
Pavlov. Cond. magazine entry latency0.30.30.3-0.6
Pavlov. Cond. change in total contacts1.52.12.1-1.5
Pavlov. Cond. index score2.02.62.6-1.6
Pavlov. Cond. latency score1.82.22.2-1.5
Pavlov. Cond. lever contacts2.43.33.3-1.8
Pavlov. Cond. magazine entry number0.91.11.11.1
Pavlov. Cond. intertrial magazine entries2.22.92.91.7
Pavlov. Cond. lever-magazine prob. diff.1.82.32.3-1.5
Pavlov. Cond. response bias2.43.23.2-1.8
Time in closed arm before self-admin1.31.41.4-1.2
Time in closed arm after self-admin0.00.00.0-0.2
Time in open arm before self-admin2.72.92.91.7
Time in open arm after self-admin1.31.41.4-1.2
Bone: periosteal estimation1.94.04.0-2.0
Bone: periosteal perimeter1.52.62.6-1.6
Bone: post-yield work0.00.00.00.2
Progressive ratio test 1 active lever presses0.00.00.00.1
Progressive ratio test 1 breakpoint0.00.00.0-0.0
Progressive ratio test 1 inactive lever presses1.31.51.51.2
Progressive ratio test 2 active lever presses0.00.00.00.2
Progressive ratio test 2 breakpoint0.00.00.00.0
Progressive ratio test 2 inactive lever presses0.00.10.10.2
Incentive Sensitization - Responses0.20.20.2-0.5
Incentive Sensitization - Breakpoint0.10.10.1-0.4
Sum of active levers in priming session hrs 5-61.01.01.0-1.0
Progressive ratio0.00.00.00.1
Food seeking constrained by brief footshock1.82.22.21.5
Seeking ratio, punishment vs. effort0.70.80.80.9
Retroperitoneal fat weight0.82.52.51.6
Reaction time number correct0.50.70.70.8
Reaction time mean minus median0.00.00.0-0.1
Reaction time mean minus median AUC0.10.20.2-0.4
Reaction time num false alarms3.95.45.42.3
Reaction time num false alarms AUC3.64.94.92.2
Reaction time trials correct on left0.50.70.70.8
Reaction time trials on left0.50.70.70.9
Reaction time mean3.75.15.1-2.3
Reaction time mean AUC2.93.93.9-2.0
Median of all reaction times5.27.27.2-2.7
Reaction time omissions0.10.10.10.3
Reaction time false alarm rate1.52.22.21.5
Reaction time premature initiation rate0.20.30.3-0.6
Reaction time premature initiations0.00.00.00.0
Std. dev. reaction times0.60.90.9-0.9
Reaction time trials completed0.50.70.70.9
Reaction time trials AUC0.30.50.50.7
Run reversals in cocaine runway, females1.01.01.01.0
Run reversals in cocaine runway, males0.20.20.2-0.4
Latency to leave start box in cocaine runway2.62.82.81.7
Latency to leave start box in cocaine runway, F2.12.32.31.5
Latency to leave start box in cocaine runway, M0.00.00.0-0.0
Std. dev. time between licks in bursts3.13.73.71.9
Total sessions with >9 infusions0.10.10.10.3
Short access day 1 total inactive lever presses0.00.00.00.1
Short access day 10 total inactive lever presses1.11.21.2-1.1
Short access day 1 total infusions0.30.30.30.6
Short access day 10 total infusions0.10.10.1-0.3
Short access total infusions0.70.80.80.9
Short access day 1 locomotion0.91.01.0-1.0
Short access day 10 total locomotion0.30.30.3-0.5
Short access total locomotion0.00.00.00.1
One hour access (0.3 mA shock)0.30.30.3-0.6
Compulsive drug intake0.20.20.2-0.5
One hour access (shock baseline)0.00.00.0-0.1
Social response proportion0.40.40.4-0.6
Social responses0.60.80.8-0.9
Social time0.30.40.4-0.7
Soleus weight0.00.00.00.0
Bone: stiffness0.60.90.9-1.0
Tibialis anterior weight0.41.31.31.1
Time to tail flick, vehicle, before self-admin0.10.10.10.3
Time to tail flick, vehicle, after self-admin0.50.60.6-0.7
Time to tail flick, test, before self-admin0.30.30.3-0.5
Time to tail flick, test, after self-admin2.22.22.21.5
Delta time to tail flick, vehicle, before/after SA0.00.00.00.1
Delta time to tail flick, test, before/after SA1.51.41.41.2
Tibia length1.74.74.7-2.2
Ambulatory time before self-admin2.12.12.1-1.5
Ambulatory time after self-admin0.91.01.01.0
Bone: tissue strength0.50.50.50.7
Total heroin consumption0.80.90.9-0.9
Bone: trabecular number0.10.20.20.5
Bone: trabecular spacing0.20.30.3-0.6
Bone: trabecular thickness0.40.40.4-0.7
Bone: trabecular tissue density0.71.01.0-1.0
Water consumed over 24 hours0.20.20.20.4
Number of responses in last shaping day0.40.40.4-0.6