Hub : Genes

Ccnd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Ccnd1 0.41 0.12 8.9e-16 0.21 0.27 0.34 0.22 2.5e-09 8.5e-12 5.2e-15 7.7e-10
2 OFC gene expression Ccnd1 0.66 0.12 2.9e-12 0.25 0.19 0.34 0.08 9.7e-07 3.0e-05 6.4e-09 6.8e-03
3 Adipose gene expression Ccnd1 0.05 0.04 1.1e-03 0.02 0.01 0.01 0.02 1.7e-03 1.1e-02 4.4e-02 4.6e-03
4 PL gene expression Ccnd1 0.07 0.04 1.1e-07 0.05 0.06 0.06 0.06 5.0e-06 5.8e-07 2.5e-07 1.6e-07
5 BLA gene expression Ccnd1 0.16 0.08 6.5e-08 0.13 0.12 0.13 0.13 2.0e-07 4.4e-07 1.5e-07 2.6e-07
6 Liver gene expression Ccnd1 0.04 0.02 1.0e-03 0.02 0.02 0.01 0.02 1.3e-03 3.3e-03 2.6e-02 5.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density1.42.46.6-1.1-0.42.3-0.8-0.7-2.6
Area under the delay curve0.50.51.2-0.4-0.71.1-0.5-0.7-0.8
BMI with tail0.72.58.80.1-0.42.2-0.7-0.8-3.0
BMI without tail0.31.03.41.00.70.80.40.2-1.8
Body weight0.73.05.62.41.9-0.31.61.3-2.1
Weight adjusted by age0.50.71.91.40.4-1.20.80.40.2
Bone surface1.22.39.8-0.10.31.8-0.3-0.5-3.1
Bone volume1.12.05.7-0.8-0.22.1-0.7-0.8-2.4
Breakpoint value in progressive ratio session1.51.82.81.11.7-0.91.61.6-1.0
Number of licking bursts0.10.10.2-0.2-0.20.4-0.2-0.2-0.5
Context. condit. distance diff. score0.50.61.5-0.6-1.20.4-1.0-0.80.4
Locomotion velocity, session 10.00.00.1-0.20.2-0.0-0.3-0.2-0.2
Locomotion distance, session 11.21.53.4-0.7-0.71.6-1.0-1.2-1.8
Locomotion velocity, session 21.21.42.91.31.7-0.41.41.1-0.8
Locomotion distance, session 20.40.61.8-0.10.01.2-0.3-0.6-1.3
Locomotion velocity, session 31.11.33.0-1.1-0.61.4-0.8-0.8-1.7
Locomotion distance, session 30.30.30.5-0.2-0.60.4-0.5-0.7-0.7
Stereotopy head waving bouts, day 30.91.11.8-1.1-0.71.3-0.8-0.8-1.3
Stereotopy head waving duration, day 31.21.42.3-1.5-1.01.5-1.1-1.1-0.7
Locomotion velocity, session 70.30.31.2-0.2-0.40.6-0.2-0.3-1.1
Locomotion distance, session 70.10.10.50.70.10.00.2-0.1-0.4
Stereotopy head waving bouts, day 71.82.12.5-1.4-1.11.6-1.5-1.4-1.6
Stereotopy head waving duration, day 70.70.93.9-0.7-0.10.8-0.4-0.2-2.0
Locomotion velocity, session 80.81.01.81.11.3-0.61.01.0-0.7
Locomotion distance, session 80.91.42.2-0.9-1.21.5-1.3-1.4-0.2
Degree of sensitization distance0.20.20.30.50.5-0.00.40.5-0.2
Degree of sensitization stereotypy0.60.71.8-0.6-0.40.7-0.8-0.7-1.3
Conditioned locomotion2.93.44.82.02.1-2.21.81.70.9
Cocaine response after cond. corrected0.00.00.1-0.4-0.10.2-0.00.2-0.1
Cocaine response after cond. not corrected0.30.40.8-0.8-0.50.9-0.4-0.1-0.5
Cocaine response before conditioning0.30.40.9-0.6-0.40.9-0.5-0.5-0.6
Saline control response1.21.62.61.61.6-0.71.41.1-1.0
Bone: connectivity density1.21.88.4-0.10.11.5-0.2-0.2-2.9
Bone: cortical apparent density1.21.63.41.10.8-1.91.31.40.9
Bone: cortical area0.20.40.70.70.8-0.30.70.50.5
Bone: cortical porosity0.10.10.3-0.1-0.60.3-0.4-0.5-0.2
Bone: cortical porosity0.00.00.20.4-0.2-0.0-0.0-0.1-0.2
Bone: cortical thickness3.45.67.92.82.6-2.32.62.21.1
Bone: cortical thickness1.41.72.21.51.4-1.31.51.40.2
Bone: cortical tissue density1.52.03.91.31.0-2.01.51.50.9
Condit. Reinf. active minus inactive responses0.60.71.0-0.4-1.00.9-1.0-0.9-0.6
Condit. Reinf. active-inactive response ratio1.21.32.3-0.4-1.41.1-1.4-1.5-0.3
Condit. Reinf. active responses0.30.30.5-0.4-0.70.5-0.7-0.70.1
Condit. Reinf. inactive responses0.10.10.2-0.20.4-0.30.30.40.5
Incentive salience index mean0.50.61.0-0.4-0.91.0-1.0-0.9-0.4
Condit. Reinf. lever presses0.10.10.2-0.1-0.30.3-0.4-0.30.3
Condit. Reinf. active minus inactive responses1.62.03.7-1.9-1.41.4-1.4-1.0-1.3
Condit. Reinf. active-inactive response ratio2.93.44.9-2.2-2.11.8-2.0-1.9-0.5
Condit. Reinf. active responses0.91.23.6-1.4-0.80.8-0.8-0.3-1.9
Condit. Reinf. inactive responses0.60.82.60.40.6-0.40.71.0-1.6
Condit. Reinf. lever presses0.60.93.4-0.6-0.01.2-0.3-0.1-1.9
Condit. Reinf. lever reinforcers received0.81.14.3-1.2-0.60.7-0.5-0.0-2.1
Conditioned reinforcement - actives0.10.10.40.1-0.2-0.6-0.0-0.20.6
Conditioned reinforcement - inactives1.52.23.7-1.9-1.71.6-1.6-1.30.3
Conditioned locomotion5.06.69.7-2.6-3.11.9-2.9-2.81.7
Patch foraging indifference point 0 sec0.00.00.1-0.30.2-0.0-0.20.1-0.3
Patch foraging indifference point AUC0.71.01.61.01.2-0.91.21.00.5
Delay disc. indifference point, 0s delay1.71.82.7-1.0-1.31.6-1.2-1.3-1.6
Delay disc. indifference point, 16s delay1.41.62.5-1.0-1.41.4-1.3-1.60.3
Delay disc. indifference point, 2s delay0.91.02.1-0.9-1.01.5-0.9-1.1-0.7
Delay disc. indifference point, 24s delay0.50.50.80.90.8-0.80.70.50.7
Delay disc. indifference point, 4s delay0.10.10.3-0.3-0.40.4-0.1-0.1-0.5
Delay disc. indifference point, 8s delay0.10.10.20.2-0.30.4-0.2-0.3-0.5
Indifference point function ln k1.22.13.1-1.8-1.70.9-1.6-1.50.8
Indifference point function log k1.22.13.1-1.8-1.70.9-1.6-1.50.8
Patch foraging total patch changes 0 sec0.20.40.90.31.0-0.70.60.80.0
Patch foraging total patch changes 12 sec1.82.33.31.61.8-1.41.61.7-0.7
Patch foraging total patch changes 18 sec0.20.40.70.50.8-0.10.70.7-0.6
Patch foraging total patch changes 24 sec0.91.53.61.01.9-0.61.51.4-0.1
Patch foraging total patch changes 6 sec0.40.61.90.60.90.20.60.6-1.4
Patch foraging time to switch 0 sec0.51.04.70.3-0.50.9-0.4-0.1-2.2
Patch foraging water rate 0 sec0.71.47.1-0.9-0.1-0.7-0.1-0.32.7
Patch foraging water rate 12 sec1.63.49.1-1.7-1.60.4-1.6-1.83.0
Patch foraging water rate 18 sec0.61.01.3-1.1-1.00.6-1.0-1.01.1
Patch foraging water rate 24 sec0.71.05.2-0.3-0.4-0.5-0.4-0.52.3
Patch foraging water rate 6 sec0.50.73.9-0.20.0-0.20.1-0.52.0
Seeking ratio, delayed vs. immediate footshock0.30.41.3-0.5-0.30.8-0.3-0.1-1.1
Distance traveled before self-admin0.60.71.1-0.5-0.80.8-1.1-1.0-1.0
Distance traveled after self-admin0.10.20.4-0.3-0.10.6-0.5-0.2-0.5
Extensor digitorum longus weight3.513.825.15.04.6-2.83.93.4-1.3
Bone: elastic displacement1.21.45.21.20.6-1.20.50.12.3
Bone: elastic work1.41.84.02.01.5-1.11.20.81.0
Bone: endosteal estimation2.24.98.5-2.2-1.92.9-2.4-2.4-1.0
Bone: endosteal perimeter3.57.510.9-3.2-2.53.3-3.0-2.7-1.2
Epididymis fat weight2.68.912.3-3.3-3.52.5-3.4-3.21.5
Delta time in closed arm before/after self-admin1.00.91.71.30.9-0.91.11.0-0.1
Delta time in open arm before/after self-admin0.30.30.5-0.7-0.50.6-0.6-0.6-0.4
Diff in mean of infusions in LGA sessions0.70.81.30.71.0-0.91.11.1-0.4
Delay discount exponential model param0.30.30.70.20.5-0.80.30.50.7
Extinction: sum of active levers before priming0.50.61.60.60.80.00.70.6-1.3
Active lever presses in extinction session 60.70.71.61.30.9-0.60.90.60.3
Bone: final force0.40.61.30.81.10.10.70.6-1.0
Bone: final moment0.40.61.20.81.10.20.60.6-0.9
Food consumed during 24 hour testing period0.40.51.0-0.5-1.00.6-0.6-0.90.6
Glucose3.14.97.0-2.6-2.62.2-2.4-1.9-1.1
Heart weight1.62.54.7-1.7-1.02.1-1.2-0.9-2.2
Delay discount hyperbolic model param0.40.40.90.40.6-1.00.40.60.7
Intermittent access intake day 1-15 change0.91.83.1-1.7-1.81.0-1.4-1.10.9
Intermittent access intake escalation0.71.42.3-1.5-1.50.8-1.3-1.00.9
Intermittent access intake escalation 21.01.22.0-1.3-1.40.7-1.2-0.80.8
Intermitt. access day 1 inactive lever presses0.00.10.40.20.4-0.30.20.30.6
Intermitt. access day 15 inactive lever presses0.91.92.9-1.6-1.61.7-1.4-1.1-0.3
Intermitt. access escalation Index1.01.42.7-1.0-1.50.5-1.2-1.11.6
Intermittent access day 1 total infusions2.64.27.2-2.0-2.22.7-2.2-1.7-1.1
Intermittent access day 15 total infusions3.85.67.9-2.8-2.82.6-2.7-2.10.2
Intermittent access terminal intake (last 3 days)4.05.37.2-2.7-2.72.6-2.6-2.0-0.2
Intermittent access total infusions2.83.35.2-2.2-1.92.3-2.0-1.4-0.6
Intermittent access day 1 locomotion1.21.52.5-1.3-1.41.6-1.4-1.1-0.3
Intermittent access day 15 total locomotion3.25.87.8-2.8-2.82.6-2.7-2.30.3
Intermittent access total locomotion6.98.210.8-3.2-3.33.2-3.2-2.70.1
Intermittent access standard deviation0.40.81.1-1.1-1.10.9-0.9-0.70.4
Left kidney weight0.94.36.7-2.2-2.61.8-2.3-2.30.6
Right kidney weight0.41.93.1-1.5-1.70.8-1.4-1.51.2
Cocaine induced anxiety0.20.30.4-0.3-0.60.6-0.5-0.6-0.4
Post-drug Anxiety0.10.10.40.6-0.0-0.30.10.0-0.3
Baseline Anxiety0.80.91.31.10.9-1.10.90.90.4
Tail length1.14.46.22.42.5-2.02.42.20.4
Length with tail1.87.711.83.43.3-2.53.12.8-0.1
Length without tail1.34.27.22.72.2-2.22.22.0-0.1
Times rat made contact with spout0.30.31.6-0.30.20.40.30.4-1.3
Lifetime Intake1.51.82.7-1.6-1.41.6-1.5-1.0-0.4
Liver weight, left0.20.31.50.20.0-0.50.30.11.2
Liver weight, right0.20.41.2-0.6-0.7-0.3-0.4-0.41.1
Locomotor activity1.01.53.0-0.9-0.91.1-1.3-1.71.2
Locomotor testing distance0.71.32.8-0.7-0.80.7-1.2-1.41.7
Locomotor testing rearing1.22.53.4-1.5-1.81.6-1.8-1.70.1
Locomotion in novel chamber4.05.29.1-3.0-2.52.3-2.3-2.2-0.2
Locomotion in novel chamber post-restriction2.13.55.7-1.9-2.41.3-2.2-2.10.8
Fecal boli incidents, locomotor time 10.10.10.5-0.7-0.10.4-0.2-0.2-0.3
Change in fecal boli incidents, locomotor task0.40.40.80.50.4-0.70.70.9-0.2
Time >=10cm from walls, locomotor time 12.83.04.8-2.1-1.62.2-1.7-1.2-1.4
Bouts of movement, locomotor time 12.32.63.41.61.9-1.81.81.70.3
Total resting periods, locomotor time 11.31.51.91.21.4-1.41.31.30.5
Rest time, locomotor task time 10.81.03.0-0.7-1.00.3-0.8-0.91.7
Distance moved, locomotor task time 10.40.62.1-0.5-0.60.6-0.6-0.3-1.5
Vertical activity count, locomotor time 10.51.22.3-1.1-1.50.9-1.3-1.1-0.3
Time >=10cm from walls, locomotor time 20.10.10.30.10.0-0.3-0.10.10.6
Bouts of movement, locomotor time 20.40.61.11.00.7-0.90.80.80.2
Total resting periods, locomotor time 20.10.20.40.70.3-0.60.40.50.0
Rest time, locomotor task time 22.12.73.7-1.9-1.91.8-1.8-1.6-0.1
Distance moved, locomotor task time 21.01.22.21.51.1-1.41.10.70.3
Vertical activity count, locomotor time 21.21.62.61.41.1-1.51.10.61.6
Light reinforcement 10.10.30.7-0.8-0.6-0.0-0.5-0.50.5
Light reinforcement 20.91.42.2-1.5-1.20.7-1.3-1.20.9
Bone: marrow area2.35.08.7-2.2-2.03.0-2.4-2.5-1.0
Bone: maximum diameter0.20.30.8-0.6-0.20.9-0.5-0.50.2
Bone: maximum force0.81.45.2-0.00.11.6-0.4-0.5-2.3
Bone: maximum moment0.71.34.60.00.11.6-0.4-0.5-2.1
Mean time between licks in bursts0.51.22.10.91.2-0.91.41.4-0.5
Mean num. licks in bursts0.00.10.2-0.30.10.20.10.3-0.4
Cd content in liver0.91.02.3-1.2-1.50.4-1.1-1.00.3
Co content in liver1.11.33.90.30.6-1.60.50.72.0
Cu content in liver0.10.10.40.20.00.20.0-0.10.6
Fe content in liver0.10.10.30.30.5-0.20.40.3-0.0
K content in liver0.20.20.50.1-0.20.6-0.2-0.4-0.7
Mg content in liver1.11.11.6-0.9-1.31.2-1.2-1.2-0.3
Mn content in liver0.60.71.61.30.9-0.40.80.7-0.6
Na content in liver0.30.30.80.5-0.4-0.2-0.1-0.80.9
Rb content in liver0.70.82.6-1.6-0.90.7-0.80.1-0.5
Se content in liver0.70.81.8-0.2-1.01.0-0.9-1.3-0.2
Sr content in liver0.80.72.41.50.8-0.60.80.30.2
Zn content in liver0.80.91.21.11.0-1.11.00.90.5
Bone: minimum diameter2.64.77.5-2.4-2.02.7-2.3-1.9-1.4
Time in familiar zone, hab. session 11.21.22.2-1.1-1.01.5-1.1-1.1-0.4
Time in novel zone, hab. session 10.60.61.30.70.6-1.20.70.80.4
Total zone transitions, hab. session 10.60.92.2-0.1-0.31.5-0.7-1.3-0.9
Total locomotion distance, hab. session 11.82.54.8-1.2-1.51.9-1.7-2.2-0.1
Locomotion velocity, hab. session 11.01.53.1-0.8-1.11.5-1.3-1.8-0.1
Time in familiar zone, hab. session 21.11.11.71.11.1-1.31.11.20.4
Time in novel zone, hab. session 20.60.61.2-0.8-0.60.8-0.6-0.4-1.1
Total zone transitions, hab. session 21.82.48.3-0.8-0.22.0-0.7-0.8-2.9
Total locomotion distance, hab. session 21.01.42.3-1.1-0.81.4-1.1-1.0-1.5
Locomotion velocity, hab. session 21.52.03.1-1.4-1.11.8-1.4-1.4-1.3
Novel to familiar place preference ratio0.10.10.60.00.20.10.20.3-0.8
Novelty place preference0.10.10.5-0.3-0.00.3-0.1-0.0-0.7
Time in novel zone, NPP test0.10.10.5-0.3-0.00.3-0.1-0.0-0.7
Total zone transitions, NPP test0.60.83.1-0.10.41.2-0.3-0.4-1.8
Total locomotion distance, NPP test0.40.61.1-0.8-0.41.0-0.7-0.7-0.7
Locomotion velocity, NPP test0.30.40.9-0.7-0.31.0-0.7-0.6-0.6
Intraocular pressure0.40.62.5-0.2-0.2-0.90.10.21.6
Delta distance traveled before/after self-admin0.20.20.50.10.7-0.10.60.70.2
Delta ambulatory time before/after self-admin0.40.51.10.30.9-0.30.91.00.3
Parametrial fat weight1.43.26.2-2.5-2.41.2-2.0-1.30.4
Pavlov. Cond. lever latency0.20.20.8-0.1-0.2-0.90.20.20.6
Pavlov. Cond. magazine entry latency0.40.51.0-0.7-0.60.7-0.6-0.3-1.0
Pavlov. Cond. change in total contacts0.80.81.3-1.1-0.91.0-1.0-0.6-0.6
Pavlov. Cond. index score0.20.30.7-0.5-0.50.8-0.6-0.6-0.1
Pavlov. Cond. latency score0.20.30.8-0.4-0.40.9-0.6-0.4-0.3
Pavlov. Cond. lever contacts0.20.30.9-0.3-0.20.9-0.5-0.5-0.5
Pavlov. Cond. magazine entry number0.00.00.10.20.3-0.00.10.0-0.1
Pavlov. Cond. intertrial magazine entries0.20.20.9-0.00.4-0.50.20.30.9
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.5-0.60.9-0.7-0.6-0.2
Pavlov. Cond. response bias0.10.10.3-0.3-0.40.5-0.4-0.40.0
Pavlov. Cond. lever latency0.10.20.60.50.1-0.80.20.40.1
Pavlov. Cond. magazine entry latency1.21.44.40.50.90.21.21.2-2.1
Pavlov. Cond. change in total contacts0.30.51.9-0.6-0.11.0-0.1-0.1-1.4
Pavlov. Cond. index score0.30.41.6-0.10.20.70.30.2-1.3
Pavlov. Cond. latency score0.20.31.0-0.10.10.80.2-0.0-1.0
Pavlov. Cond. lever contacts0.10.20.5-0.6-0.00.7-0.1-0.2-0.4
Pavlov. Cond. magazine entry number1.11.34.6-0.7-1.0-0.4-1.1-0.92.1
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.4-0.4-0.4-0.4-0.30.9
Pavlov. Cond. lever-magazine prob. diff.0.30.41.80.10.40.60.50.3-1.3
Pavlov. Cond. response bias0.40.52.1-0.40.20.70.30.3-1.4
Time in closed arm before self-admin0.50.61.5-1.2-0.90.7-0.7-0.5-0.2
Time in closed arm after self-admin0.20.20.4-0.20.4-0.40.60.70.1
Time in open arm before self-admin0.80.92.31.50.9-1.10.70.40.7
Time in open arm after self-admin0.10.10.60.80.2-0.40.00.0-0.1
Bone: periosteal estimation0.40.92.5-0.8-0.51.6-1.0-1.1-0.3
Bone: periosteal perimeter0.40.71.5-1.1-0.31.2-0.9-0.4-0.8
Bone: post-yield work5.88.414.9-2.5-2.33.9-2.6-2.3-3.4
Progressive ratio test 1 active lever presses0.10.10.3-0.10.5-0.30.40.50.1
Progressive ratio test 1 breakpoint0.10.10.3-0.00.5-0.30.40.60.1
Progressive ratio test 1 inactive lever presses0.00.00.1-0.00.2-0.0-0.00.10.3
Progressive ratio test 2 active lever presses1.31.52.3-1.3-1.51.2-1.5-1.10.2
Progressive ratio test 2 breakpoint1.11.32.1-1.2-1.41.1-1.4-1.00.2
Progressive ratio test 2 inactive lever presses4.47.110.0-2.8-3.22.7-3.1-2.60.8
Incentive Sensitization - Responses0.30.40.6-0.4-0.70.7-0.7-0.3-0.8
Incentive Sensitization - Breakpoint0.40.60.9-0.5-0.90.9-0.9-0.4-0.7
Sum of active levers in priming session hrs 5-61.51.33.40.81.2-1.11.00.51.8
Progressive ratio1.21.88.8-0.50.01.2-0.40.1-3.0
Food seeking constrained by brief footshock0.10.10.20.40.2-0.20.30.4-0.3
Seeking ratio, punishment vs. effort0.81.15.60.3-0.3-0.80.2-0.22.4
Retroperitoneal fat weight4.720.030.9-5.1-5.63.4-5.0-4.71.9
Reaction time number correct0.00.10.30.60.2-0.10.2-0.30.2
Reaction time mean minus median0.20.41.80.50.50.10.40.4-1.4
Reaction time mean minus median AUC0.10.30.70.50.7-0.10.50.5-0.9
Reaction time num false alarms0.81.11.60.71.1-1.31.01.01.2
Reaction time num false alarms AUC1.32.02.91.11.7-1.61.51.50.7
Reaction time trials correct on left0.00.10.30.60.2-0.10.2-0.30.2
Reaction time trials on left0.10.10.50.70.3-0.10.3-0.20.2
Reaction time mean0.40.61.1-0.5-0.71.0-0.6-0.7-1.1
Reaction time mean AUC0.60.91.5-0.6-1.01.2-0.8-0.8-1.1
Median of all reaction times0.71.01.5-0.8-1.11.2-0.8-0.9-1.1
Reaction time omissions0.81.11.71.21.2-0.61.31.1-0.8
Reaction time false alarm rate1.11.52.10.81.4-1.41.21.40.8
Reaction time premature initiation rate1.42.04.42.11.4-1.31.51.1-0.3
Reaction time premature initiations1.52.76.22.51.8-1.51.81.2-0.1
Std. dev. reaction times0.10.31.30.00.20.30.20.2-1.1
Reaction time trials completed0.10.10.50.70.3-0.10.3-0.20.2
Reaction time trials AUC0.00.10.30.60.3-0.00.3-0.20.1
Run reversals in cocaine runway, females0.30.31.60.20.3-0.10.30.4-1.3
Run reversals in cocaine runway, males0.70.71.10.50.7-0.90.90.91.0
Latency to leave start box in cocaine runway1.11.21.8-0.9-1.11.3-1.2-1.1-1.0
Latency to leave start box in cocaine runway, F0.70.81.3-0.6-1.21.0-1.0-0.9-0.8
Latency to leave start box in cocaine runway, M0.10.10.2-0.20.30.4-0.10.0-0.4
Std. dev. time between licks in bursts1.92.63.71.41.7-1.81.81.90.8
Total sessions with >9 infusions0.10.10.60.00.3-0.00.10.3-0.7
Short access day 1 total inactive lever presses0.81.02.1-1.5-1.01.0-1.1-0.90.3
Short access day 10 total inactive lever presses0.00.10.2-0.00.00.2-0.2-0.40.3
Short access day 1 total infusions0.50.71.2-0.9-1.00.7-1.1-0.90.2
Short access day 10 total infusions0.81.13.0-1.1-0.51.2-0.6-0.1-1.7
Short access total infusions0.20.30.8-0.5-0.20.6-0.4-0.0-0.9
Short access day 1 locomotion0.80.91.4-1.1-1.21.0-1.2-0.9-0.0
Short access day 10 total locomotion0.40.71.2-1.1-0.91.0-0.8-0.7-0.5
Short access total locomotion0.80.91.3-1.1-1.11.1-1.1-0.9-0.2
One hour access (0.3 mA shock)3.84.36.3-2.1-2.52.1-2.4-2.10.5
Compulsive drug intake3.23.85.42.12.3-2.22.21.8-0.0
One hour access (shock baseline)4.26.59.8-2.7-3.12.5-2.9-2.50.9
Social response proportion0.20.20.80.10.1-0.30.30.7-0.9
Social responses0.10.20.20.40.5-0.50.40.5-0.2
Social time0.20.20.30.50.4-0.40.60.6-0.3
Soleus weight0.92.64.7-2.1-1.50.3-1.6-1.42.2
Bone: stiffness0.91.45.7-0.50.01.5-0.4-0.2-2.4
Tibialis anterior weight4.314.532.35.74.7-2.94.02.70.3
Time to tail flick, vehicle, before self-admin0.80.84.1-0.70.00.30.20.4-2.0
Time to tail flick, vehicle, after self-admin0.40.62.90.30.30.70.00.1-1.7
Time to tail flick, test, before self-admin2.12.13.4-1.6-1.11.9-1.4-1.2-1.5
Time to tail flick, test, after self-admin0.40.51.00.20.9-0.40.81.00.2
Delta time to tail flick, vehicle, before/after SA0.20.20.30.60.50.50.10.2-0.5
Delta time to tail flick, test, before/after SA5.45.57.32.02.4-2.72.62.51.7
Tibia length0.20.51.91.00.2-0.30.2-0.31.4
Ambulatory time before self-admin0.71.11.7-0.6-1.10.9-1.3-1.2-1.0
Ambulatory time after self-admin1.61.92.9-1.4-1.31.7-1.7-1.3-0.8
Bone: tissue strength1.61.73.8-1.3-1.01.9-1.2-1.4-0.3
Total heroin consumption3.33.85.82.02.4-1.72.22.2-0.7
Bone: trabecular number1.11.96.3-0.9-0.31.8-0.6-0.4-2.5
Bone: trabecular spacing0.40.62.10.60.2-0.90.30.21.5
Bone: trabecular thickness1.62.03.7-1.7-0.91.9-1.2-1.1-1.4
Bone: trabecular tissue density1.62.35.2-1.7-1.60.3-1.3-1.32.3
Water consumed over 24 hours0.30.41.90.30.30.60.10.0-1.4
Number of responses in last shaping day0.10.10.20.50.3-0.40.20.20.4