Ccnd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Ccnd1	0.41	0.12	8.9e-16	0.21	0.27	0.34	0.22	2.5e-09	8.5e-12	5.2e-15	7.6e-10
2	OFC	gene expression	Ccnd1	0.66	0.12	2.9e-12	0.25	0.19	0.34	0.08	9.7e-07	3.0e-05	6.4e-09	6.7e-03
3	Adipose	gene expression	Ccnd1	0.05	0.04	1.1e-03	0.02	0.01	0.01	0.02	1.7e-03	1.1e-02	4.4e-02	4.5e-03
4	PL	gene expression	Ccnd1	0.07	0.04	1.1e-07	0.05	0.06	0.06	0.06	5.0e-06	5.8e-07	2.5e-07	1.6e-07
5	BLA	gene expression	Ccnd1	0.16	0.08	6.5e-08	0.13	0.12	0.13	0.13	2.0e-07	4.4e-07	1.5e-07	2.6e-07
6	Liver	gene expression	Ccnd1	0.04	0.02	1.0e-03	0.02	0.02	0.01	0.02	1.3e-03	3.3e-03	2.6e-02	5.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.3	2.4	6.6	1.2	0.4	-2.3	-0.8	0.7	2.6
Area under the delay curve	0.3	0.5	1.2	0.4	0.7	-1.1	-0.5	0.7	0.8
BMI with tail	0.7	2.5	8.8	-0.1	0.4	-2.2	-0.7	0.8	3.0
BMI without tail	0.2	1.0	3.4	-1.0	-0.7	-0.8	0.4	-0.2	1.8
Body weight	0.7	3.0	5.4	-2.3	-1.9	0.3	1.6	-1.3	2.1
Weight adjusted by age	0.2	0.7	1.9	-1.4	-0.4	1.2	0.8	-0.4	-0.2
Bone surface	1.1	2.3	9.8	0.1	-0.3	-1.8	-0.3	0.5	3.1
Bone volume	1.0	2.0	5.7	0.8	0.2	-2.1	-0.7	0.8	2.4
Breakpoint value in progressive ratio session	1.0	1.8	2.8	-1.0	-1.7	0.9	1.6	-1.6	1.0
Number of licking bursts	0.0	0.1	0.2	0.2	0.2	-0.4	-0.2	0.2	0.5
Context. condit. distance diff. score	0.5	0.6	1.5	0.6	1.2	-0.4	-1.0	0.8	-0.4
Locomotion velocity, session 1	0.0	0.0	0.1	0.2	-0.2	0.0	-0.3	0.2	0.2
Locomotion distance, session 1	1.2	1.5	3.4	0.7	0.7	-1.6	-1.0	1.2	1.8
Locomotion velocity, session 2	1.2	1.4	2.9	-1.3	-1.7	0.4	1.4	-1.1	0.8
Locomotion distance, session 2	0.4	0.6	1.8	0.2	-0.0	-1.2	-0.3	0.6	1.3
Locomotion velocity, session 3	1.1	1.3	3.0	1.1	0.6	-1.4	-0.8	0.8	1.7
Locomotion distance, session 3	0.3	0.3	0.5	0.2	0.6	-0.4	-0.5	0.7	0.7
Stereotopy head waving bouts, day 3	0.9	1.1	1.8	1.1	0.7	-1.3	-0.8	0.8	1.3
Stereotopy head waving duration, day 3	1.1	1.4	2.3	1.5	1.0	-1.5	-1.1	1.1	0.7
Locomotion velocity, session 7	0.3	0.3	1.2	0.2	0.4	-0.6	-0.3	0.3	1.1
Locomotion distance, session 7	0.1	0.1	0.5	-0.7	-0.1	-0.0	0.2	0.1	0.4
Stereotopy head waving bouts, day 7	1.8	2.1	2.5	1.4	1.1	-1.6	-1.5	1.4	1.6
Stereotopy head waving duration, day 7	0.7	0.9	3.9	0.7	0.1	-0.8	-0.4	0.2	2.0
Locomotion velocity, session 8	0.8	1.0	1.8	-1.0	-1.3	0.6	1.0	-1.0	0.7
Locomotion distance, session 8	0.9	1.4	2.2	0.9	1.2	-1.5	-1.3	1.4	0.2
Degree of sensitization distance	0.1	0.2	0.3	-0.5	-0.5	0.0	0.4	-0.5	0.2
Degree of sensitization stereotypy	0.6	0.7	1.8	0.6	0.4	-0.7	-0.8	0.7	1.3
Conditioned locomotion	2.9	3.4	4.8	-2.0	-2.1	2.2	1.8	-1.7	-0.9
Cocaine response after cond. corrected	0.0	0.0	0.1	0.4	0.1	-0.2	-0.0	-0.2	0.1
Cocaine response after cond. not corrected	0.3	0.4	0.8	0.8	0.5	-0.9	-0.4	0.1	0.5
Cocaine response before conditioning	0.3	0.4	0.9	0.6	0.4	-0.9	-0.5	0.5	0.6
Saline control response	1.2	1.6	2.6	-1.6	-1.6	0.7	1.4	-1.1	1.0
Bone: connectivity density	1.1	1.8	8.4	0.2	-0.1	-1.5	-0.2	0.2	2.9
Bone: cortical apparent density	1.0	1.6	3.4	-1.1	-0.8	1.9	1.3	-1.4	-0.9
Bone: cortical area	0.2	0.4	0.7	-0.7	-0.8	0.3	0.7	-0.5	-0.5
Bone: cortical porosity	0.1	0.1	0.3	0.1	0.6	-0.3	-0.4	0.5	0.2
Bone: cortical porosity	0.0	0.0	0.2	-0.4	0.2	0.0	-0.0	0.1	0.2
Bone: cortical thickness	3.3	5.6	7.9	-2.8	-2.6	2.3	2.6	-2.2	-1.1
Bone: cortical thickness	1.4	1.7	2.2	-1.5	-1.4	1.3	1.5	-1.4	-0.2
Bone: cortical tissue density	1.2	2.0	3.9	-1.3	-1.0	2.0	1.5	-1.5	-0.9
Condit. Reinf. active minus inactive responses	0.6	0.7	1.0	0.4	1.0	-0.9	-1.0	0.9	0.6
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.3	0.4	1.4	-1.1	-1.4	1.5	0.3
Condit. Reinf. active responses	0.2	0.3	0.5	0.4	0.7	-0.5	-0.7	0.7	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.2	-0.4	0.3	0.3	-0.4	-0.5
Incentive salience index mean	0.5	0.6	1.0	0.4	0.9	-1.0	-1.0	0.9	0.4
Condit. Reinf. lever presses	0.1	0.1	0.2	0.1	0.3	-0.3	-0.4	0.3	-0.3
Condit. Reinf. active minus inactive responses	1.3	2.0	3.7	1.9	1.4	-1.4	-1.4	1.0	1.3
Condit. Reinf. active-inactive response ratio	2.1	3.4	4.9	2.2	2.1	-1.8	-2.0	1.9	0.5
Condit. Reinf. active responses	0.9	1.2	3.6	1.4	0.8	-0.8	-0.8	0.3	1.9
Condit. Reinf. inactive responses	0.5	0.8	2.6	-0.3	-0.6	0.4	0.7	-1.0	1.6
Condit. Reinf. lever presses	0.6	0.9	3.4	0.6	0.0	-1.2	-0.3	0.1	1.9
Condit. Reinf. lever reinforcers received	0.8	1.1	4.3	1.2	0.6	-0.7	-0.5	0.0	2.1
Conditioned reinforcement - actives	0.0	0.1	0.4	-0.1	0.2	0.6	-0.0	0.2	-0.6
Conditioned reinforcement - inactives	0.8	2.2	3.7	1.9	1.7	-1.6	-1.6	1.3	-0.3
Conditioned locomotion	4.4	6.5	9.7	2.6	3.1	-1.9	-2.9	2.8	-1.7
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.3	-0.2	0.0	-0.2	-0.1	0.3
Patch foraging indifference point AUC	0.4	1.0	1.6	-1.0	-1.2	0.9	1.2	-1.0	-0.5
Delay disc. indifference point, 0s delay	1.6	1.8	2.7	1.0	1.3	-1.6	-1.2	1.3	1.6
Delay disc. indifference point, 16s delay	1.1	1.6	2.5	1.0	1.4	-1.4	-1.3	1.6	-0.3
Delay disc. indifference point, 2s delay	0.9	1.1	2.1	0.9	1.0	-1.5	-0.9	1.1	0.7
Delay disc. indifference point, 24s delay	0.3	0.5	0.8	-0.9	-0.8	0.8	0.7	-0.5	-0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.3	0.4	-0.4	-0.1	0.1	0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.2	0.3	-0.4	-0.2	0.3	0.5
Indifference point function ln k	0.7	2.1	3.1	1.8	1.7	-0.9	-1.6	1.5	-0.8
Indifference point function log k	0.7	2.1	3.1	1.8	1.7	-0.9	-1.6	1.5	-0.8
Patch foraging total patch changes 0 sec	0.2	0.4	0.9	-0.3	-1.0	0.7	0.6	-0.8	-0.0
Patch foraging total patch changes 12 sec	1.7	2.3	3.3	-1.6	-1.8	1.4	1.6	-1.7	0.7
Patch foraging total patch changes 18 sec	0.2	0.4	0.7	-0.5	-0.8	0.1	0.7	-0.7	0.6
Patch foraging total patch changes 24 sec	0.4	1.5	3.6	-1.0	-1.9	0.6	1.5	-1.4	0.1
Patch foraging total patch changes 6 sec	0.4	0.6	1.9	-0.6	-0.9	-0.2	0.6	-0.6	1.4
Patch foraging time to switch 0 sec	0.3	1.0	4.7	-0.3	0.5	-0.9	-0.4	0.1	2.2
Patch foraging water rate 0 sec	0.4	1.4	7.1	0.9	0.1	0.7	-0.1	0.3	-2.7
Patch foraging water rate 12 sec	0.8	3.4	9.1	1.7	1.6	-0.4	-1.6	1.8	-3.0
Patch foraging water rate 18 sec	0.4	1.0	1.3	1.1	1.0	-0.6	-1.0	1.0	-1.1
Patch foraging water rate 24 sec	0.7	1.0	5.2	0.3	0.4	0.5	-0.4	0.5	-2.3
Patch foraging water rate 6 sec	0.5	0.7	3.9	0.2	-0.0	0.2	0.1	0.5	-2.0
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.3	0.5	0.3	-0.8	-0.3	0.1	1.1
Distance traveled before self-admin	0.3	0.7	1.1	0.5	0.8	-0.8	-1.1	1.0	1.0
Distance traveled after self-admin	0.1	0.2	0.4	0.3	0.1	-0.6	-0.5	0.2	0.5
Extensor digitorum longus weight	3.4	13.7	24.9	-5.0	-4.6	2.8	3.9	-3.4	1.3
Bone: elastic displacement	1.1	1.5	5.2	-1.2	-0.6	1.2	0.5	-0.1	-2.3
Bone: elastic work	1.4	1.8	4.1	-2.0	-1.5	1.1	1.2	-0.8	-1.0
Bone: endosteal estimation	2.0	4.9	8.5	2.2	1.9	-2.9	-2.4	2.4	1.0
Bone: endosteal perimeter	3.1	7.5	10.9	3.2	2.5	-3.3	-3.0	2.7	1.2
Epididymis fat weight	1.8	8.9	12.3	3.3	3.5	-2.5	-3.4	3.2	-1.5
Delta time in closed arm before/after self-admin	1.0	0.9	1.7	-1.3	-0.9	0.9	1.1	-1.0	0.1
Delta time in open arm before/after self-admin	0.3	0.3	0.5	0.7	0.5	-0.6	-0.6	0.6	0.4
Diff in mean of infusions in LGA sessions	0.5	0.8	1.3	-0.7	-1.0	0.9	1.1	-1.1	0.4
Delay discount exponential model param	0.2	0.3	0.7	-0.2	-0.5	0.8	0.3	-0.5	-0.7
Extinction: sum of active levers before priming	0.4	0.6	1.6	-0.6	-0.8	-0.0	0.7	-0.6	1.3
Active lever presses in extinction session 6	0.7	0.7	1.6	-1.3	-0.9	0.6	0.9	-0.6	-0.3
Bone: final force	0.4	0.6	1.3	-0.7	-1.1	-0.1	0.7	-0.6	1.0
Bone: final moment	0.4	0.6	1.2	-0.8	-1.1	-0.2	0.6	-0.6	0.9
Food consumed during 24 hour testing period	0.3	0.5	1.0	0.5	1.0	-0.6	-0.6	0.9	-0.6
Glucose	3.1	4.9	7.0	2.6	2.6	-2.2	-2.4	1.9	1.1
Heart weight	1.6	2.5	4.7	1.7	1.0	-2.1	-1.2	0.9	2.2
Delay discount hyperbolic model param	0.3	0.4	0.9	-0.4	-0.6	1.0	0.4	-0.6	-0.7
Intermittent access intake day 1-15 change	0.3	1.8	3.1	1.7	1.8	-1.0	-1.4	1.1	-0.9
Intermittent access intake escalation	0.3	1.4	2.3	1.5	1.5	-0.8	-1.3	1.0	-0.9
Intermittent access intake escalation 2	0.7	1.2	2.0	1.3	1.4	-0.7	-1.2	0.8	-0.8
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.4	-0.2	-0.4	0.3	0.2	-0.3	-0.6
Intermitt. access day 15 inactive lever presses	0.4	1.9	2.9	1.6	1.6	-1.7	-1.4	1.1	0.3
Intermitt. access escalation Index	0.5	1.4	2.7	1.0	1.5	-0.5	-1.2	1.1	-1.6
Intermittent access day 1 total infusions	1.4	4.2	7.2	2.0	2.2	-2.7	-2.2	1.7	1.1
Intermittent access day 15 total infusions	2.3	5.6	7.8	2.8	2.8	-2.6	-2.7	2.1	-0.2
Intermittent access terminal intake (last 3 days)	3.0	5.3	7.2	2.7	2.7	-2.6	-2.6	2.0	0.2
Intermittent access total infusions	2.8	3.3	5.2	2.2	1.9	-2.3	-2.0	1.4	0.6
Intermittent access day 1 locomotion	0.8	1.5	2.5	1.3	1.4	-1.6	-1.4	1.1	0.3
Intermittent access day 15 total locomotion	1.5	5.8	7.8	2.8	2.8	-2.6	-2.7	2.3	-0.3
Intermittent access total locomotion	6.8	8.2	10.8	3.2	3.3	-3.2	-3.2	2.7	-0.1
Intermittent access standard deviation	0.1	0.8	1.1	1.1	1.1	-0.9	-0.9	0.7	-0.4
Left kidney weight	0.5	4.3	6.7	2.2	2.6	-1.8	-2.3	2.3	-0.6
Right kidney weight	0.3	1.9	3.1	1.5	1.7	-0.8	-1.4	1.5	-1.2
Cocaine induced anxiety	0.1	0.3	0.4	0.3	0.6	-0.6	-0.5	0.6	0.4
Post-drug Anxiety	0.1	0.1	0.4	-0.6	0.0	0.3	0.1	-0.0	0.3
Baseline Anxiety	0.5	0.9	1.3	-1.1	-0.9	1.1	0.9	-0.9	-0.4
Tail length	0.8	4.4	6.2	-2.4	-2.5	2.0	2.4	-2.2	-0.4
Length with tail	1.7	7.7	11.7	-3.4	-3.3	2.5	3.1	-2.8	0.1
Length without tail	0.8	4.2	7.2	-2.7	-2.2	2.2	2.2	-2.0	0.1
Times rat made contact with spout	0.3	0.3	1.6	0.3	-0.2	-0.4	0.3	-0.4	1.3
Lifetime Intake	1.4	1.8	2.7	1.6	1.4	-1.6	-1.5	1.0	0.4
Liver weight, left	0.2	0.3	1.5	-0.2	-0.0	0.5	0.3	-0.1	-1.2
Liver weight, right	0.2	0.4	1.2	0.6	0.7	0.3	-0.4	0.4	-1.1
Locomotor activity	1.0	1.5	3.0	0.8	0.9	-1.1	-1.3	1.7	-1.2
Locomotor testing distance	0.5	1.3	2.8	0.7	0.8	-0.7	-1.2	1.4	-1.7
Locomotor testing rearing	0.7	2.5	3.4	1.5	1.8	-1.6	-1.8	1.7	-0.1
Locomotion in novel chamber	3.8	5.2	9.1	3.0	2.5	-2.3	-2.3	2.2	0.2
Locomotion in novel chamber post-restriction	1.1	3.5	5.7	1.9	2.4	-1.3	-2.2	2.1	-0.8
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.7	0.1	-0.4	-0.2	0.2	0.3
Change in fecal boli incidents, locomotor task	0.3	0.4	0.8	-0.5	-0.4	0.7	0.7	-0.9	0.2
Time >=10cm from walls, locomotor time 1	2.4	3.0	4.8	2.1	1.6	-2.2	-1.7	1.2	1.4
Bouts of movement, locomotor time 1	2.0	2.6	3.4	-1.6	-1.9	1.8	1.8	-1.7	-0.3
Total resting periods, locomotor time 1	1.3	1.5	1.9	-1.2	-1.4	1.4	1.3	-1.3	-0.5
Rest time, locomotor task time 1	0.6	1.0	3.0	0.7	1.0	-0.3	-0.8	0.9	-1.7
Distance moved, locomotor task time 1	0.2	0.6	2.1	0.5	0.6	-0.6	-0.6	0.3	1.5
Vertical activity count, locomotor time 1	0.2	1.2	2.3	1.0	1.5	-0.9	-1.3	1.1	0.3
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	-0.1	-0.0	0.3	-0.1	-0.1	-0.6
Bouts of movement, locomotor time 2	0.2	0.6	1.1	-1.0	-0.7	0.9	0.8	-0.8	-0.2
Total resting periods, locomotor time 2	0.1	0.2	0.4	-0.7	-0.3	0.6	0.4	-0.5	-0.0
Rest time, locomotor task time 2	1.6	2.7	3.7	1.9	1.9	-1.8	-1.8	1.6	0.1
Distance moved, locomotor task time 2	0.9	1.2	2.2	-1.5	-1.1	1.4	1.1	-0.7	-0.3
Vertical activity count, locomotor time 2	0.7	1.6	2.6	-1.5	-1.1	1.5	1.1	-0.6	-1.6
Light reinforcement 1	0.1	0.3	0.7	0.8	0.6	0.0	-0.5	0.5	-0.5
Light reinforcement 2	0.6	1.4	2.1	1.5	1.2	-0.7	-1.3	1.2	-0.9
Bone: marrow area	2.1	5.1	8.7	2.2	2.0	-3.0	-2.4	2.5	1.0
Bone: maximum diameter	0.1	0.3	0.8	0.6	0.2	-0.9	-0.5	0.5	-0.2
Bone: maximum force	0.7	1.4	5.2	0.1	-0.1	-1.6	-0.4	0.5	2.3
Bone: maximum moment	0.7	1.3	4.6	-0.0	-0.1	-1.6	-0.4	0.5	2.1
Mean time between licks in bursts	0.2	1.2	2.1	-0.9	-1.2	0.9	1.4	-1.4	0.5
Mean num. licks in bursts	0.0	0.1	0.2	0.3	-0.1	-0.2	0.1	-0.3	0.4
Cd content in liver	0.9	1.0	2.3	1.2	1.5	-0.4	-1.1	1.0	-0.3
Co content in liver	1.1	1.3	3.9	-0.4	-0.6	1.6	0.5	-0.7	-2.0
Cu content in liver	0.1	0.1	0.4	-0.3	-0.0	-0.2	0.0	0.1	-0.6
Fe content in liver	0.1	0.1	0.3	-0.3	-0.5	0.2	0.4	-0.3	0.0
K content in liver	0.2	0.2	0.5	-0.1	0.2	-0.6	-0.2	0.4	0.7
Mg content in liver	1.0	1.1	1.6	0.9	1.3	-1.2	-1.2	1.2	0.3
Mn content in liver	0.6	0.7	1.6	-1.3	-0.9	0.4	0.8	-0.7	0.6
Na content in liver	0.3	0.3	0.8	-0.5	0.4	0.2	-0.1	0.8	-0.9
Rb content in liver	0.7	0.8	2.6	1.6	0.9	-0.7	-0.8	-0.1	0.5
Se content in liver	0.7	0.8	1.8	0.2	1.0	-1.0	-0.9	1.3	0.2
Sr content in liver	0.8	0.7	2.4	-1.5	-0.8	0.6	0.8	-0.3	-0.2
Zn content in liver	0.8	0.9	1.2	-1.1	-1.0	1.1	1.0	-0.9	-0.5
Bone: minimum diameter	2.5	4.7	7.5	2.4	2.0	-2.7	-2.3	1.9	1.4
Time in familiar zone, hab. session 1	1.1	1.2	2.2	1.1	1.0	-1.5	-1.1	1.1	0.4
Time in novel zone, hab. session 1	0.5	0.6	1.3	-0.7	-0.6	1.2	0.7	-0.8	-0.4
Total zone transitions, hab. session 1	0.6	0.9	2.2	0.1	0.3	-1.5	-0.7	1.3	0.9
Total locomotion distance, hab. session 1	1.8	2.5	4.8	1.2	1.5	-1.9	-1.7	2.2	0.1
Locomotion velocity, hab. session 1	1.0	1.5	3.1	0.8	1.1	-1.5	-1.3	1.8	0.1
Time in familiar zone, hab. session 2	1.0	1.1	1.7	-1.1	-1.1	1.3	1.1	-1.2	-0.4
Time in novel zone, hab. session 2	0.5	0.6	1.2	0.8	0.6	-0.8	-0.6	0.4	1.1
Total zone transitions, hab. session 2	1.8	2.4	8.3	0.8	0.2	-2.0	-0.7	0.8	2.9
Total locomotion distance, hab. session 2	1.0	1.4	2.3	1.1	0.8	-1.4	-1.1	1.0	1.5
Locomotion velocity, hab. session 2	1.5	2.0	3.1	1.4	1.1	-1.8	-1.4	1.4	1.3
Novel to familiar place preference ratio	0.1	0.1	0.6	-0.0	-0.2	-0.1	0.2	-0.3	0.8
Novelty place preference	0.1	0.1	0.5	0.3	0.0	-0.3	-0.1	0.0	0.7
Time in novel zone, NPP test	0.1	0.1	0.5	0.3	0.0	-0.3	-0.1	0.0	0.7
Total zone transitions, NPP test	0.6	0.8	3.1	0.1	-0.4	-1.2	-0.3	0.4	1.8
Total locomotion distance, NPP test	0.4	0.6	1.1	0.8	0.4	-1.0	-0.7	0.7	0.7
Locomotion velocity, NPP test	0.3	0.4	0.9	0.7	0.3	-1.0	-0.7	0.6	0.6
Intraocular pressure	0.3	0.6	2.5	0.2	0.2	0.9	0.1	-0.2	-1.6
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.1	-0.7	0.1	0.6	-0.7	-0.2
Delta ambulatory time before/after self-admin	0.3	0.5	1.1	-0.3	-0.9	0.3	0.9	-1.0	-0.3
Parametrial fat weight	1.4	3.2	6.2	2.5	2.4	-1.2	-2.0	1.3	-0.4
Pavlov. Cond. lever latency	0.2	0.2	0.8	0.1	0.2	0.9	0.2	-0.2	-0.6
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	0.7	0.6	-0.7	-0.6	0.3	1.0
Pavlov. Cond. change in total contacts	0.7	0.8	1.3	1.1	0.9	-1.0	-1.0	0.6	0.6
Pavlov. Cond. index score	0.2	0.3	0.7	0.5	0.5	-0.8	-0.6	0.6	0.1
Pavlov. Cond. latency score	0.2	0.3	0.8	0.4	0.4	-0.9	-0.6	0.4	0.3
Pavlov. Cond. lever contacts	0.2	0.3	0.9	0.3	0.2	-0.9	-0.5	0.5	0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	-0.3	0.0	0.1	-0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.9	0.0	-0.4	0.5	0.2	-0.3	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.5	0.6	-0.9	-0.7	0.6	0.2
Pavlov. Cond. response bias	0.1	0.1	0.3	0.3	0.4	-0.5	-0.4	0.4	-0.0
Pavlov. Cond. lever latency	0.1	0.2	0.6	-0.5	-0.1	0.8	0.2	-0.4	-0.1
Pavlov. Cond. magazine entry latency	1.0	1.4	4.4	-0.5	-0.9	-0.2	1.2	-1.2	2.1
Pavlov. Cond. change in total contacts	0.2	0.5	1.9	0.6	0.1	-1.0	-0.1	0.1	1.4
Pavlov. Cond. index score	0.2	0.4	1.6	0.1	-0.2	-0.7	0.3	-0.2	1.3
Pavlov. Cond. latency score	0.2	0.3	1.0	0.1	-0.1	-0.8	0.2	0.0	1.0
Pavlov. Cond. lever contacts	0.1	0.2	0.5	0.6	0.0	-0.7	-0.1	0.2	0.4
Pavlov. Cond. magazine entry number	1.0	1.3	4.6	0.7	1.0	0.4	-1.1	0.9	-2.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.7	0.4	0.4	0.4	-0.4	0.3	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.8	-0.1	-0.4	-0.6	0.5	-0.3	1.3
Pavlov. Cond. response bias	0.4	0.5	2.1	0.4	-0.2	-0.7	0.3	-0.3	1.4
Time in closed arm before self-admin	0.3	0.6	1.5	1.2	0.9	-0.7	-0.7	0.5	0.2
Time in closed arm after self-admin	0.2	0.2	0.4	0.2	-0.4	0.4	0.6	-0.7	-0.1
Time in open arm before self-admin	0.7	0.9	2.3	-1.5	-0.9	1.1	0.7	-0.4	-0.7
Time in open arm after self-admin	0.1	0.1	0.6	-0.8	-0.2	0.4	0.0	-0.0	0.1
Bone: periosteal estimation	0.4	0.9	2.5	0.8	0.5	-1.6	-1.0	1.1	0.3
Bone: periosteal perimeter	0.4	0.7	1.5	1.1	0.3	-1.2	-0.9	0.4	0.8
Bone: post-yield work	4.9	8.5	14.9	2.6	2.3	-3.9	-2.6	2.3	3.4
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.1	-0.5	0.3	0.4	-0.5	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.0	-0.5	0.3	0.4	-0.6	-0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.0	-0.2	0.0	-0.0	-0.1	-0.3
Progressive ratio test 2 active lever presses	1.1	1.5	2.3	1.3	1.5	-1.2	-1.5	1.1	-0.2
Progressive ratio test 2 breakpoint	1.0	1.3	2.1	1.2	1.4	-1.1	-1.4	1.0	-0.2
Progressive ratio test 2 inactive lever presses	2.2	7.1	10.0	2.8	3.2	-2.7	-3.1	2.6	-0.8
Incentive Sensitization - Responses	0.1	0.4	0.6	0.4	0.7	-0.7	-0.7	0.3	0.8
Incentive Sensitization - Breakpoint	0.3	0.6	0.9	0.5	0.9	-0.9	-0.9	0.4	0.7
Sum of active levers in priming session hrs 5-6	1.4	1.4	3.4	-0.8	-1.2	1.1	1.0	-0.5	-1.8
Progressive ratio	0.6	1.8	8.8	0.5	-0.0	-1.2	-0.4	-0.1	3.0
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.4	-0.2	0.2	0.3	-0.4	0.3
Seeking ratio, punishment vs. effort	0.5	1.1	5.6	-0.3	0.3	0.8	0.2	0.2	-2.4
Retroperitoneal fat weight	4.4	19.9	30.9	5.1	5.6	-3.4	-5.0	4.7	-1.9
Reaction time number correct	0.0	0.1	0.3	-0.6	-0.2	0.1	0.2	0.3	-0.2
Reaction time mean minus median	0.1	0.4	1.8	-0.5	-0.5	-0.1	0.4	-0.4	1.4
Reaction time mean minus median AUC	0.1	0.3	0.7	-0.5	-0.7	0.1	0.5	-0.5	0.9
Reaction time num false alarms	0.7	1.1	1.6	-0.7	-1.1	1.3	1.0	-1.0	-1.2
Reaction time num false alarms AUC	0.9	2.0	2.9	-1.1	-1.7	1.6	1.5	-1.5	-0.7
Reaction time trials correct on left	0.0	0.1	0.3	-0.6	-0.2	0.1	0.2	0.3	-0.2
Reaction time trials on left	0.0	0.1	0.5	-0.7	-0.3	0.1	0.3	0.2	-0.2
Reaction time mean	0.3	0.6	1.1	0.5	0.7	-1.0	-0.6	0.7	1.1
Reaction time mean AUC	0.4	0.9	1.5	0.6	1.0	-1.2	-0.8	0.8	1.1
Median of all reaction times	0.6	1.0	1.5	0.8	1.1	-1.2	-0.8	0.9	1.1
Reaction time omissions	0.7	1.1	1.7	-1.2	-1.2	0.6	1.3	-1.1	0.8
Reaction time false alarm rate	1.1	1.5	2.1	-0.8	-1.4	1.4	1.2	-1.4	-0.8
Reaction time premature initiation rate	1.3	2.0	4.4	-2.1	-1.4	1.3	1.5	-1.1	0.3
Reaction time premature initiations	0.9	2.7	6.2	-2.5	-1.8	1.5	1.8	-1.2	0.1
Std. dev. reaction times	0.1	0.3	1.3	-0.0	-0.2	-0.3	0.2	-0.2	1.1
Reaction time trials completed	0.0	0.1	0.5	-0.7	-0.3	0.1	0.3	0.2	-0.2
Reaction time trials AUC	0.0	0.1	0.3	-0.6	-0.3	0.0	0.3	0.2	-0.1
Run reversals in cocaine runway, females	0.3	0.3	1.6	-0.2	-0.3	0.1	0.3	-0.4	1.3
Run reversals in cocaine runway, males	0.6	0.7	1.1	-0.5	-0.7	0.9	0.9	-0.9	-1.0
Latency to leave start box in cocaine runway	0.9	1.2	1.8	0.9	1.1	-1.3	-1.2	1.1	1.0
Latency to leave start box in cocaine runway, F	0.7	0.8	1.3	0.6	1.2	-1.0	-1.0	0.9	0.8
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.2	-0.3	-0.4	-0.1	-0.0	0.4
Std. dev. time between licks in bursts	1.4	2.6	3.7	-1.4	-1.7	1.8	1.8	-1.9	-0.8
Total sessions with >9 infusions	0.1	0.1	0.6	-0.0	-0.3	0.0	0.1	-0.3	0.7
Short access day 1 total inactive lever presses	0.5	1.0	2.1	1.4	1.0	-1.0	-1.1	0.9	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.0	-0.0	-0.2	-0.2	0.4	-0.3
Short access day 1 total infusions	0.4	0.7	1.2	0.9	1.0	-0.7	-1.1	0.9	-0.2
Short access day 10 total infusions	0.6	1.1	3.0	1.1	0.5	-1.2	-0.6	0.1	1.7
Short access total infusions	0.2	0.3	0.8	0.6	0.2	-0.6	-0.4	0.0	0.9
Short access day 1 locomotion	0.6	0.9	1.4	1.1	1.2	-1.0	-1.2	0.9	0.0
Short access day 10 total locomotion	0.2	0.7	1.2	1.1	0.9	-1.0	-0.8	0.7	0.5
Short access total locomotion	0.6	0.9	1.3	1.1	1.1	-1.1	-1.1	0.9	0.2
One hour access (0.3 mA shock)	3.6	4.3	6.3	2.1	2.5	-2.1	-2.4	2.1	-0.5
Compulsive drug intake	2.6	3.8	5.4	-2.1	-2.3	2.2	2.2	-1.8	0.0
One hour access (shock baseline)	2.5	6.5	9.8	2.7	3.1	-2.5	-2.9	2.5	-0.9
Social response proportion	0.2	0.2	0.8	-0.1	-0.1	0.3	0.3	-0.7	0.9
Social responses	0.1	0.2	0.2	-0.4	-0.5	0.5	0.4	-0.5	0.2
Social time	0.1	0.2	0.3	-0.5	-0.4	0.4	0.6	-0.6	0.3
Soleus weight	0.9	2.6	4.7	2.0	1.5	-0.3	-1.6	1.4	-2.2
Bone: stiffness	0.8	1.4	5.7	0.5	-0.0	-1.5	-0.4	0.2	2.4
Tibialis anterior weight	4.2	14.4	32.2	-5.7	-4.7	2.9	4.0	-2.7	-0.3
Time to tail flick, vehicle, before self-admin	0.7	0.8	4.1	0.7	-0.0	-0.3	0.2	-0.4	2.0
Time to tail flick, vehicle, after self-admin	0.3	0.6	2.9	-0.3	-0.3	-0.7	0.0	-0.1	1.7
Time to tail flick, test, before self-admin	1.9	2.2	3.4	1.7	1.1	-1.9	-1.4	1.2	1.5
Time to tail flick, test, after self-admin	0.4	0.5	1.0	-0.2	-0.9	0.4	0.8	-1.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	-0.6	-0.5	-0.5	0.1	-0.2	0.5
Delta time to tail flick, test, before/after SA	4.5	5.5	7.3	-2.0	-2.4	2.7	2.6	-2.5	-1.7
Tibia length	0.2	0.5	1.9	-1.0	-0.2	0.3	0.2	0.3	-1.4
Ambulatory time before self-admin	0.4	1.1	1.7	0.6	1.1	-0.9	-1.3	1.2	1.0
Ambulatory time after self-admin	1.2	1.9	2.9	1.4	1.3	-1.7	-1.7	1.3	0.8
Bone: tissue strength	1.6	1.7	3.8	1.3	1.0	-1.9	-1.2	1.4	0.3
Total heroin consumption	3.2	3.8	5.8	-2.0	-2.4	1.7	2.2	-2.2	0.7
Bone: trabecular number	1.0	1.9	6.3	0.9	0.3	-1.8	-0.6	0.4	2.5
Bone: trabecular spacing	0.4	0.6	2.1	-0.6	-0.2	0.9	0.3	-0.2	-1.5
Bone: trabecular thickness	1.5	2.0	3.7	1.7	0.9	-1.9	-1.2	1.1	1.4
Bone: trabecular tissue density	1.3	2.3	5.2	1.6	1.6	-0.3	-1.3	1.3	-2.3
Water consumed over 24 hours	0.2	0.4	1.9	-0.3	-0.3	-0.6	0.1	-0.0	1.4
Number of responses in last shaping day	0.1	0.1	0.2	-0.5	-0.3	0.4	0.2	-0.2	-0.4