Hub : Genes

Ccdc8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Ccdc8	0.09	0.08	2.5e-05	0.03	0.04	0.03	0.03	1.2e-03	3.9e-04	1.6e-03	1.8e-03
2	Adipose	gene expression	Ccdc8	0.06	0.04	2.5e-06	0.04	0.04	0.04	0.04	1.5e-05	1.1e-05	3.3e-05	3.5e-05
3	Brain	gene expression	Ccdc8	0.16	0.21	7.1e-09	0.09	0.09	0.08	0.09	1.3e-08	1.9e-08	4.3e-08	1.5e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.0	0.1	0.1	-0.3	-0.3	0.2
Area under the delay curve	0.5	0.8	0.8	0.9	0.9	-0.9
BMI with tail	1.1	3.9	4.0	-2.0	-2.0	2.0
BMI without tail	1.0	5.4	5.6	-2.4	-2.3	2.3
Body weight	2.2	9.5	9.5	-3.1	-3.1	3.1
Weight adjusted by age	0.0	0.1	0.2	-0.3	-0.3	0.4
Bone surface	0.6	1.1	1.2	-1.1	-1.1	1.0
Bone volume	0.3	0.6	0.6	-0.8	-0.8	0.8
Breakpoint value in progressive ratio session	2.2	4.0	4.1	2.0	2.0	-2.0
Number of licking bursts	1.4	4.2	4.2	-2.1	-2.1	2.0
Context. condit. distance diff. score	0.0	0.0	0.0	-0.2	-0.2	0.2
Locomotion velocity, session 1	0.2	0.2	0.3	0.5	0.5	-0.4
Locomotion distance, session 1	0.0	0.0	0.0	0.2	0.1	-0.1
Locomotion velocity, session 2	1.8	2.2	2.2	-1.5	-1.5	1.5
Locomotion distance, session 2	0.5	0.7	0.8	-0.8	-0.8	0.9
Locomotion velocity, session 3	0.3	0.4	0.4	-0.6	-0.6	0.7
Locomotion distance, session 3	0.7	0.8	0.9	0.9	0.9	-0.9
Stereotopy head waving bouts, day 3	0.9	1.1	1.2	-1.0	-1.0	1.1
Stereotopy head waving duration, day 3	0.6	0.7	0.8	-0.8	-0.8	0.9
Locomotion velocity, session 7	0.6	0.7	0.7	0.8	0.8	-0.8
Locomotion distance, session 7	0.0	0.0	0.1	-0.2	-0.2	0.2
Stereotopy head waving bouts, day 7	0.5	0.6	0.7	-0.8	-0.8	0.8
Stereotopy head waving duration, day 7	0.5	0.6	0.7	-0.8	-0.8	0.8
Locomotion velocity, session 8	0.0	0.0	0.0	0.1	0.1	-0.1
Locomotion distance, session 8	0.0	0.0	0.0	-0.1	-0.1	0.2
Degree of sensitization distance	0.8	0.9	1.0	-0.9	-0.9	1.0
Degree of sensitization stereotypy	0.7	0.7	0.7	-0.8	-0.9	0.9
Conditioned locomotion	0.1	0.2	0.2	0.4	0.4	-0.5
Cocaine response after cond. corrected	0.3	0.4	0.4	-0.6	-0.6	0.6
Cocaine response after cond. not corrected	0.9	1.3	1.3	-1.1	-1.1	1.1
Cocaine response before conditioning	2.0	2.4	2.4	-1.5	-1.5	1.5
Saline control response	1.4	1.9	2.0	-1.4	-1.4	1.4
Bone: connectivity density	0.0	0.1	0.1	-0.3	-0.3	0.2
Bone: cortical apparent density	0.0	0.1	0.1	0.2	0.2	-0.3
Bone: cortical area	1.9	3.0	3.1	-1.7	-1.7	1.8
Bone: cortical porosity	0.1	0.1	0.1	0.4	0.4	-0.4
Bone: cortical porosity	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: cortical thickness	0.5	0.9	0.9	-1.0	-1.0	1.0
Bone: cortical thickness	1.0	1.2	1.2	-1.1	-1.1	1.1
Bone: cortical tissue density	0.1	0.1	0.1	0.3	0.3	-0.4
Condit. Reinf. active minus inactive responses	0.9	1.0	1.1	-1.0	-1.0	1.0
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.0	-0.9	-1.0	1.0
Condit. Reinf. active responses	0.5	0.7	0.7	-0.8	-0.8	0.8
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	0.3	-0.3
Incentive salience index mean	0.8	1.0	1.0	-1.0	-1.0	1.0
Condit. Reinf. lever presses	0.3	0.4	0.4	-0.6	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	-0.1	0.1
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.1	-0.3	-0.3	0.2
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	0.3	-0.3
Condit. Reinf. inactive responses	0.3	0.5	0.5	0.7	0.7	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.1	-0.4	-0.4	0.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.1	0.3	0.3	-0.3
Conditioned reinforcement - actives	1.1	4.4	4.7	-2.0	-2.1	2.2
Conditioned reinforcement - inactives	1.2	3.2	3.4	-1.7	-1.8	1.8
Conditioned locomotion	1.5	2.2	2.5	-1.4	-1.4	1.6
Patch foraging indifference point 0 sec	0.2	0.5	0.5	-0.7	-0.7	0.7
Patch foraging indifference point AUC	2.7	6.4	6.7	-2.5	-2.5	2.6
Delay disc. indifference point, 0s delay	0.3	0.4	0.4	0.6	0.6	-0.6
Delay disc. indifference point, 16s delay	0.2	0.3	0.3	0.5	0.5	-0.5
Delay disc. indifference point, 2s delay	1.5	1.7	1.8	1.4	1.3	-1.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.0	-0.1	0.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.3	-0.4	-0.4	0.5
Delay disc. indifference point, 8s delay	1.0	1.6	1.7	1.3	1.3	-1.3
Indifference point function ln k	1.1	3.3	3.3	1.8	1.8	-1.8
Indifference point function log k	1.1	3.3	3.3	1.8	1.8	-1.8
Patch foraging total patch changes 0 sec	0.2	0.6	0.6	-0.8	-0.8	0.8
Patch foraging total patch changes 12 sec	2.4	3.3	3.5	-1.8	-1.8	1.9
Patch foraging total patch changes 18 sec	1.3	3.1	3.2	-1.8	-1.8	1.8
Patch foraging total patch changes 24 sec	0.5	1.8	2.0	-1.3	-1.3	1.4
Patch foraging total patch changes 6 sec	2.3	3.8	4.0	-1.9	-1.9	2.0
Patch foraging time to switch 0 sec	0.9	3.5	3.7	1.9	1.9	-1.8
Patch foraging water rate 0 sec	1.2	4.4	4.6	-2.2	-2.2	2.0
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.3	-0.3	0.2
Patch foraging water rate 18 sec	0.0	0.0	0.1	-0.2	-0.2	0.2
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.2	-0.1	-0.1
Patch foraging water rate 6 sec	0.6	1.0	1.0	-1.0	-1.0	0.9
Seeking ratio, delayed vs. immediate footshock	1.9	2.8	3.0	1.6	1.6	-1.7
Distance traveled before self-admin	0.0	0.0	0.0	-0.0	-0.0	0.1
Distance traveled after self-admin	0.5	1.0	1.0	1.0	1.0	-1.0
Extensor digitorum longus weight	2.4	9.4	9.5	-3.1	-3.1	3.1
Bone: elastic displacement	0.7	0.9	0.9	1.0	1.0	-0.9
Bone: elastic work	0.1	0.1	0.2	-0.4	-0.4	0.4
Bone: endosteal estimation	0.0	0.0	0.0	-0.0	-0.0	0.0
Bone: endosteal perimeter	0.1	0.2	0.2	-0.4	-0.4	0.4
Epididymis fat weight	0.1	0.3	0.4	0.5	0.5	-0.6
Delta time in closed arm before/after self-admin	0.6	0.5	0.5	0.7	0.7	-0.7
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.4	-0.4	0.5
Diff in mean of infusions in LGA sessions	1.6	2.8	2.9	1.7	1.7	-1.7
Delay discount exponential model param	0.4	0.5	0.6	-0.7	-0.7	0.7
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.1	0.1	-0.1
Active lever presses in extinction session 6	0.4	0.4	0.4	-0.6	-0.6	0.7
Bone: final force	0.7	1.1	1.1	-1.0	-1.0	1.0
Bone: final moment	1.0	1.6	1.6	-1.3	-1.3	1.3
Food consumed during 24 hour testing period	3.5	7.0	7.1	2.7	2.6	-2.6
Glucose	0.7	1.1	1.2	1.0	1.0	-1.1
Heart weight	1.2	2.0	2.1	-1.4	-1.4	1.4
Delay discount hyperbolic model param	0.3	0.4	0.4	-0.7	-0.6	0.6
Intermittent access intake day 1-15 change	0.1	0.4	0.5	-0.6	-0.6	0.7
Intermittent access intake escalation	0.1	0.6	0.7	-0.7	-0.7	0.9
Intermittent access intake escalation 2	0.0	0.0	0.0	0.2	0.2	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.5	0.5	-0.7	-0.7	0.7
Intermitt. access day 15 inactive lever presses	0.1	0.5	0.7	-0.6	-0.6	0.8
Intermitt. access escalation Index	0.2	0.5	0.6	0.7	0.7	-0.8
Intermittent access day 1 total infusions	1.4	4.1	4.5	-2.1	-2.1	1.9
Intermittent access day 15 total infusions	0.8	1.9	2.0	-1.4	-1.4	1.4
Intermittent access terminal intake (last 3 days)	1.0	1.7	1.7	-1.3	-1.3	1.3
Intermittent access total infusions	2.7	3.2	3.4	-1.8	-1.8	1.7
Intermittent access day 1 locomotion	0.5	1.0	1.1	-1.0	-1.0	1.0
Intermittent access day 15 total locomotion	0.1	0.3	0.4	-0.6	-0.6	0.5
Intermittent access total locomotion	2.0	2.4	2.4	-1.5	-1.5	1.6
Intermittent access standard deviation	0.1	0.3	0.3	0.5	0.6	-0.5
Left kidney weight	3.4	27.3	27.7	-5.3	-5.2	5.2
Right kidney weight	3.4	24.0	24.3	-4.9	-4.9	4.9
Cocaine induced anxiety	0.0	0.0	0.0	0.1	0.2	-0.2
Post-drug Anxiety	0.0	0.1	0.1	0.2	0.2	-0.3
Baseline Anxiety	0.5	0.9	1.0	1.0	1.0	-0.9
Tail length	0.8	4.0	4.1	-2.0	-2.0	2.0
Length with tail	0.8	3.5	3.7	-1.9	-1.8	1.9
Length without tail	0.3	1.6	1.8	-1.2	-1.2	1.3
Times rat made contact with spout	0.3	0.3	0.3	0.6	0.6	-0.5
Lifetime Intake	3.0	3.7	3.9	-2.0	-1.9	1.9
Liver weight, left	2.9	5.0	5.4	-2.2	-2.2	2.3
Liver weight, right	2.2	3.8	3.9	-2.0	-1.9	1.9
Locomotor activity	1.7	2.6	2.8	-1.7	-1.7	1.5
Locomotor testing distance	1.0	2.3	2.5	-1.5	-1.6	1.5
Locomotor testing rearing	2.7	9.9	10.1	-3.2	-3.2	3.1
Locomotion in novel chamber	0.9	1.3	1.3	1.1	1.1	-1.1
Locomotion in novel chamber post-restriction	0.5	1.4	1.5	1.2	1.2	-1.1
Fecal boli incidents, locomotor time 1	0.2	0.4	0.5	-0.6	-0.6	0.7
Change in fecal boli incidents, locomotor task	0.8	0.9	1.1	0.9	0.9	-1.0
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	0.0	0.1
Bouts of movement, locomotor time 1	3.1	4.0	4.1	2.0	2.0	-1.9
Total resting periods, locomotor time 1	3.8	4.4	4.6	2.1	2.1	-2.0
Rest time, locomotor task time 1	0.1	0.2	0.2	0.5	0.5	-0.2
Distance moved, locomotor task time 1	0.2	0.6	0.8	-0.9	-0.9	0.6
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.4	-0.4	0.2
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	-0.1	0.2
Bouts of movement, locomotor time 2	2.5	8.2	8.3	2.9	2.9	-2.8
Total resting periods, locomotor time 2	1.9	7.8	8.0	2.8	2.8	-2.7
Rest time, locomotor task time 2	0.3	0.4	0.5	0.7	0.7	-0.5
Distance moved, locomotor task time 2	0.8	1.0	1.2	-1.1	-1.1	0.8
Vertical activity count, locomotor time 2	0.0	0.1	0.1	-0.3	-0.3	0.1
Light reinforcement 1	0.1	0.3	0.4	-0.4	-0.5	0.6
Light reinforcement 2	0.5	1.1	1.3	-1.0	-1.0	1.1
Bone: marrow area	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: maximum diameter	2.4	4.8	4.9	-2.2	-2.2	2.2
Bone: maximum force	0.3	0.6	0.7	-0.8	-0.8	0.8
Bone: maximum moment	0.5	0.9	1.0	-1.0	-1.0	0.9
Mean time between licks in bursts	0.0	0.0	0.0	0.0	0.0	-0.1
Mean num. licks in bursts	2.2	6.0	6.1	2.5	2.5	-2.4
Cd content in liver	0.3	0.4	0.4	0.6	0.6	-0.5
Co content in liver	1.0	1.2	1.3	1.1	1.1	-1.1
Cu content in liver	0.5	0.6	0.6	-0.8	-0.7	0.7
Fe content in liver	3.4	4.2	4.3	-2.1	-2.1	2.0
K content in liver	0.3	0.3	0.4	-0.6	-0.6	0.5
Mg content in liver	0.7	0.7	0.8	-0.9	-0.9	0.8
Mn content in liver	0.9	1.0	1.2	-1.1	-1.0	0.9
Na content in liver	0.0	0.0	0.0	0.0	0.0	-0.1
Rb content in liver	0.0	0.0	0.0	-0.2	-0.2	0.2
Se content in liver	5.1	6.0	6.1	-2.5	-2.5	2.4
Sr content in liver	0.1	0.1	0.1	-0.3	-0.3	0.3
Zn content in liver	2.0	2.3	2.5	-1.5	-1.5	1.6
Bone: minimum diameter	0.4	0.8	0.8	-0.9	-0.9	0.9
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.3	-0.3	0.4
Time in novel zone, hab. session 1	0.6	0.7	0.7	-0.9	-0.8	0.8
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.2	-0.2	0.3
Total locomotion distance, hab. session 1	0.3	0.5	0.5	0.7	0.7	-0.7
Locomotion velocity, hab. session 1	1.1	1.5	1.7	1.3	1.3	-1.2
Time in familiar zone, hab. session 2	0.4	0.5	0.5	-0.7	-0.7	0.7
Time in novel zone, hab. session 2	0.4	0.4	0.4	0.7	0.7	-0.7
Total zone transitions, hab. session 2	0.4	0.5	0.6	-0.7	-0.7	0.8
Total locomotion distance, hab. session 2	0.5	0.6	0.7	0.8	0.8	-0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.3	0.6	0.6	-0.5
Novel to familiar place preference ratio	0.5	0.7	0.7	-0.8	-0.8	0.8
Novelty place preference	0.4	0.5	0.6	-0.7	-0.7	0.8
Time in novel zone, NPP test	0.5	0.6	0.7	-0.8	-0.8	0.8
Total zone transitions, NPP test	0.1	0.1	0.1	-0.3	-0.4	0.4
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.1	-0.2	0.2
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.2	-0.2	0.2
Intraocular pressure	0.0	0.1	0.1	0.3	0.3	-0.2
Delta distance traveled before/after self-admin	0.9	1.0	1.1	1.0	1.0	-1.1
Delta ambulatory time before/after self-admin	0.2	0.3	0.3	0.5	0.5	-0.6
Parametrial fat weight	0.0	0.0	0.1	-0.2	-0.2	0.2
Pavlov. Cond. lever latency	0.6	0.7	0.8	0.8	0.9	-0.9
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	-0.5	-0.6	0.5
Pavlov. Cond. change in total contacts	0.4	0.4	0.4	0.7	0.6	-0.6
Pavlov. Cond. index score	0.4	0.5	0.5	-0.7	-0.7	0.7
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.4	-0.4	0.4
Pavlov. Cond. lever contacts	0.4	0.5	0.5	-0.7	-0.7	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.4	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.0	-0.0	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	-0.7	-0.7	0.8
Pavlov. Cond. response bias	1.3	1.6	1.6	-1.2	-1.3	1.3
Pavlov. Cond. lever latency	0.1	0.2	0.2	0.4	0.4	-0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.0	-0.0	0.0
Pavlov. Cond. change in total contacts	0.2	0.4	0.4	0.6	0.6	-0.6
Pavlov. Cond. index score	0.0	0.0	0.0	0.1	0.1	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	0.2	-0.2
Pavlov. Cond. lever contacts	0.2	0.4	0.4	-0.6	-0.6	0.6
Pavlov. Cond. magazine entry number	0.3	0.3	0.3	-0.6	-0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.0	-0.1	-0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.1	0.1
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.2	-0.2	0.2
Time in closed arm before self-admin	0.5	0.8	0.8	-0.9	-0.9	0.9
Time in closed arm after self-admin	1.6	1.9	2.0	1.3	1.3	-1.4
Time in open arm before self-admin	0.4	0.5	0.6	0.7	0.7	-0.8
Time in open arm after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1
Bone: periosteal estimation	0.4	1.0	1.0	-1.0	-1.0	1.0
Bone: periosteal perimeter	0.6	1.3	1.3	-1.1	-1.1	1.1
Bone: post-yield work	0.2	0.4	0.5	0.6	0.6	-0.7
Progressive ratio test 1 active lever presses	2.9	5.0	5.3	-2.3	-2.2	2.2
Progressive ratio test 1 breakpoint	2.7	4.6	4.8	-2.2	-2.1	2.1
Progressive ratio test 1 inactive lever presses	1.4	3.7	3.9	-2.0	-1.9	1.8
Progressive ratio test 2 active lever presses	3.6	5.1	5.3	-2.3	-2.3	2.3
Progressive ratio test 2 breakpoint	4.3	5.5	5.6	-2.3	-2.3	2.4
Progressive ratio test 2 inactive lever presses	0.9	2.9	3.1	-1.6	-1.7	1.8
Incentive Sensitization - Responses	1.2	3.3	3.5	-1.8	-1.8	1.9
Incentive Sensitization - Breakpoint	1.4	3.1	3.4	-1.7	-1.7	1.8
Sum of active levers in priming session hrs 5-6	1.0	0.9	0.9	1.0	1.0	-0.9
Progressive ratio	0.7	2.0	2.1	1.4	1.4	-1.4
Food seeking constrained by brief footshock	3.0	3.7	4.0	2.0	2.0	-1.8
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.3	0.2	-0.2
Retroperitoneal fat weight	0.0	0.1	0.1	-0.3	-0.3	0.2
Reaction time number correct	1.2	4.2	4.3	-2.1	-2.0	2.1
Reaction time mean minus median	0.2	1.4	1.5	1.2	1.2	-1.1
Reaction time mean minus median AUC	0.0	0.2	0.2	0.5	0.5	-0.3
Reaction time num false alarms	4.5	7.6	7.7	-2.8	-2.8	2.7
Reaction time num false alarms AUC	3.1	7.1	7.1	-2.7	-2.7	2.7
Reaction time trials correct on left	1.2	4.2	4.3	-2.1	-2.0	2.1
Reaction time trials on left	1.3	4.3	4.3	-2.1	-2.1	2.1
Reaction time mean	1.3	2.9	3.0	1.7	1.7	-1.6
Reaction time mean AUC	0.9	2.2	2.3	1.5	1.5	-1.4
Median of all reaction times	1.5	2.3	2.4	1.5	1.5	-1.5
Reaction time omissions	0.0	0.1	0.1	-0.2	-0.2	0.3
Reaction time false alarm rate	0.7	0.9	0.9	-1.0	-1.0	0.9
Reaction time premature initiation rate	0.2	0.4	0.4	0.6	0.6	-0.7
Reaction time premature initiations	0.0	0.1	0.1	-0.3	-0.3	0.3
Std. dev. reaction times	0.4	1.4	1.5	1.2	1.2	-1.1
Reaction time trials completed	1.3	4.3	4.3	-2.1	-2.1	2.1
Reaction time trials AUC	1.6	5.6	5.7	-2.4	-2.3	2.4
Run reversals in cocaine runway, females	0.5	0.6	0.7	0.8	0.8	-0.7
Run reversals in cocaine runway, males	0.3	0.4	0.5	-0.6	-0.6	0.7
Latency to leave start box in cocaine runway	0.1	0.2	0.2	0.3	0.3	-0.5
Latency to leave start box in cocaine runway, F	0.0	0.1	0.1	-0.3	-0.3	0.1
Latency to leave start box in cocaine runway, M	0.2	0.2	0.2	0.4	0.4	-0.5
Std. dev. time between licks in bursts	0.1	0.2	0.2	-0.5	-0.4	0.4
Total sessions with >9 infusions	3.6	4.4	4.6	-2.2	-2.1	2.1
Short access day 1 total inactive lever presses	1.8	3.7	3.7	-1.9	-1.9	1.9
Short access day 10 total inactive lever presses	0.2	1.2	1.2	1.1	1.1	-1.1
Short access day 1 total infusions	1.5	2.9	3.1	-1.8	-1.7	1.7
Short access day 10 total infusions	3.4	5.6	5.8	-2.4	-2.4	2.3
Short access total infusions	2.6	3.7	3.9	-2.0	-1.9	1.8
Short access day 1 locomotion	3.2	5.2	5.7	-2.4	-2.3	2.2
Short access day 10 total locomotion	0.0	0.0	0.0	0.2	0.2	-0.0
Short access total locomotion	0.8	1.1	1.3	-1.0	-1.0	1.1
One hour access (0.3 mA shock)	0.2	0.2	0.3	-0.5	-0.4	0.6
Compulsive drug intake	0.0	0.1	0.1	-0.2	-0.2	0.3
One hour access (shock baseline)	0.6	1.6	1.8	-1.3	-1.3	1.2
Social response proportion	0.5	0.6	0.8	-0.7	-0.7	0.9
Social responses	0.7	1.0	1.2	-0.9	-0.9	1.1
Social time	2.3	3.6	3.7	1.9	1.9	-1.8
Soleus weight	0.2	0.6	0.6	-0.7	-0.8	0.8
Bone: stiffness	0.8	1.5	1.6	-1.3	-1.2	1.2
Tibialis anterior weight	4.3	14.8	14.8	-3.8	-3.8	3.9
Time to tail flick, vehicle, before self-admin	1.5	1.8	2.1	-1.4	-1.4	1.2
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.4	0.6	0.6	-0.6
Time to tail flick, test, before self-admin	0.5	0.6	0.8	0.7	0.8	-0.9
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.0	-0.0	-0.0
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	0.6	0.6	-0.4
Delta time to tail flick, test, before/after SA	1.0	1.3	1.5	-1.1	-1.1	1.2
Tibia length	0.4	1.1	1.1	-1.0	-1.0	1.0
Ambulatory time before self-admin	0.0	0.1	0.1	0.2	0.2	-0.2
Ambulatory time after self-admin	1.0	1.5	1.6	1.2	1.2	-1.3
Bone: tissue strength	0.4	0.4	0.4	0.6	0.6	-0.7
Total heroin consumption	0.0	0.0	0.0	-0.2	-0.2	0.2
Bone: trabecular number	0.0	0.0	0.0	-0.1	-0.0	-0.0
Bone: trabecular spacing	0.0	0.0	0.0	0.0	0.0	0.1
Bone: trabecular thickness	1.3	1.8	2.0	-1.3	-1.3	1.4
Bone: trabecular tissue density	0.1	0.1	0.1	-0.3	-0.3	0.4
Water consumed over 24 hours	0.3	0.7	0.7	0.8	0.8	-0.8
Number of responses in last shaping day	1.7	2.1	2.5	-1.4	-1.4	1.6