Ccdc124

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye isoform ratio XM_006252867.5 0.53 0.2 2.8e-03 0.12 0.11 0.04 0.1 7.4e-03 9.3e-03 8.2e-02 1.5e-02
2 Eye isoform ratio NM_001106071.1 0.62 0.19 1.2e-03 0.15 0.16 0.11 0.13 2.8e-03 1.7e-03 9.0e-03 4.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.32.23.41.8-1.0
Area under the delay curve0.91.01.4-1.20.8
BMI with tail3.010.211.82.9-3.4
BMI without tail3.29.812.42.7-3.5
Body weight7.432.536.05.4-6.0
Weight adjusted by age1.72.63.51.3-1.9
Bone surface1.42.53.31.8-1.3
Bone volume2.03.54.32.1-1.7
Breakpoint value in progressive ratio session1.01.21.70.9-1.3
Number of licking bursts0.10.20.4-0.30.6
Context. condit. distance diff. score0.10.10.10.40.4
Locomotion velocity, session 13.53.84.32.1-1.8
Locomotion distance, session 10.60.71.41.2-0.1
Locomotion velocity, session 23.23.74.31.8-2.1
Locomotion distance, session 20.20.30.50.70.3
Locomotion velocity, session 30.00.00.1-0.10.2
Locomotion distance, session 30.10.10.10.40.3
Stereotopy head waving bouts, day 30.40.40.70.30.9
Stereotopy head waving duration, day 30.10.10.10.30.4
Locomotion velocity, session 70.80.91.0-0.91.0
Locomotion distance, session 71.92.42.7-1.51.6
Stereotopy head waving bouts, day 71.82.03.11.8-0.9
Stereotopy head waving duration, day 72.02.43.01.7-1.3
Locomotion velocity, session 80.40.51.01.0-0.1
Locomotion distance, session 80.60.91.81.3-0.2
Degree of sensitization distance1.51.51.8-1.31.1
Degree of sensitization stereotypy2.42.63.41.8-1.3
Conditioned locomotion0.10.20.2-0.40.4
Cocaine response after cond. corrected3.23.94.4-2.11.8
Cocaine response after cond. not corrected2.93.43.8-2.01.7
Cocaine response before conditioning0.30.40.50.6-0.7
Saline control response0.91.11.91.4-0.6
Bone: connectivity density0.81.31.51.2-1.1
Bone: cortical apparent density0.00.00.0-0.2-0.1
Bone: cortical area8.112.513.03.6-3.4
Bone: cortical porosity0.70.80.80.9-0.9
Bone: cortical porosity0.80.91.01.0-0.9
Bone: cortical thickness7.212.015.03.9-3.0
Bone: cortical thickness3.03.66.32.5-0.9
Bone: cortical tissue density0.00.00.1-0.30.0
Condit. Reinf. active minus inactive responses1.82.13.21.8-1.0
Condit. Reinf. active-inactive response ratio0.20.20.40.7-0.1
Condit. Reinf. active responses2.63.34.52.1-1.4
Condit. Reinf. inactive responses0.91.11.41.0-1.2
Incentive salience index mean5.77.09.23.0-2.2
Condit. Reinf. lever presses9.313.016.14.0-3.2
Condit. Reinf. active minus inactive responses0.20.30.50.7-0.2
Condit. Reinf. active-inactive response ratio0.60.70.90.9-0.7
Condit. Reinf. active responses0.10.10.1-0.10.4
Condit. Reinf. inactive responses1.72.12.6-1.61.3
Condit. Reinf. lever presses0.10.20.30.1-0.6
Condit. Reinf. lever reinforcers received0.00.00.0-0.20.2
Conditioned reinforcement - actives0.20.40.70.3-0.9
Conditioned reinforcement - inactives2.02.94.51.1-2.1
Conditioned locomotion0.00.10.1-0.3-0.2
Patch foraging indifference point 0 sec2.24.05.81.5-2.4
Patch foraging indifference point AUC0.30.40.8-0.9-0.1
Delay disc. indifference point, 0s delay2.12.33.1-1.21.8
Delay disc. indifference point, 16s delay4.34.86.1-2.51.8
Delay disc. indifference point, 2s delay0.10.10.1-0.10.3
Delay disc. indifference point, 24s delay0.40.40.8-0.90.2
Delay disc. indifference point, 4s delay0.30.30.40.7-0.3
Delay disc. indifference point, 8s delay1.11.32.1-1.50.7
Indifference point function ln k0.40.71.11.0-0.5
Indifference point function log k0.40.71.11.0-0.5
Patch foraging total patch changes 0 sec2.85.27.71.7-2.8
Patch foraging total patch changes 12 sec0.30.30.7-0.0-0.8
Patch foraging total patch changes 18 sec0.10.20.5-0.70.0
Patch foraging total patch changes 24 sec0.20.30.60.3-0.8
Patch foraging total patch changes 6 sec1.52.23.41.0-1.8
Patch foraging time to switch 0 sec0.20.40.7-0.30.8
Patch foraging water rate 0 sec1.22.53.01.4-1.7
Patch foraging water rate 12 sec0.40.80.90.9-0.8
Patch foraging water rate 18 sec0.40.60.70.8-0.6
Patch foraging water rate 24 sec2.13.03.82.0-1.5
Patch foraging water rate 6 sec0.40.71.00.6-1.0
Seeking ratio, delayed vs. immediate footshock0.20.20.40.20.7
Distance traveled before self-admin1.52.02.31.3-1.5
Distance traveled after self-admin3.13.94.21.9-2.0
Extensor digitorum longus weight0.93.44.12.0-1.7
Bone: elastic displacement0.30.40.70.8-0.3
Bone: elastic work2.22.92.91.7-1.7
Bone: endosteal estimation0.40.81.6-1.30.1
Bone: endosteal perimeter0.20.40.90.1-0.9
Epididymis fat weight1.55.16.91.8-2.6
Delta time in closed arm before/after self-admin0.70.71.2-1.10.4
Delta time in open arm before/after self-admin0.00.00.10.00.3
Diff in mean of infusions in LGA sessions1.21.52.70.5-1.7
Delay discount exponential model param0.40.50.70.8-0.5
Extinction: sum of active levers before priming0.50.60.80.9-0.6
Active lever presses in extinction session 60.00.00.1-0.20.2
Bone: final force5.99.411.52.7-3.4
Bone: final moment4.67.49.22.4-3.0
Food consumed during 24 hour testing period0.60.81.51.2-0.5
Glucose1.82.84.31.2-2.1
Heart weight3.04.66.42.5-1.7
Delay discount hyperbolic model param0.20.20.30.5-0.3
Intermittent access intake day 1-15 change0.20.50.60.8-0.5
Intermittent access intake escalation0.10.30.50.7-0.3
Intermittent access intake escalation 20.40.50.60.7-0.7
Intermitt. access day 1 inactive lever presses0.00.10.10.4-0.3
Intermitt. access day 15 inactive lever presses0.00.10.1-0.10.4
Intermitt. access escalation Index0.91.31.7-0.91.3
Intermittent access day 1 total infusions0.30.51.1-1.0-0.0
Intermittent access day 15 total infusions0.00.00.1-0.20.0
Intermittent access terminal intake (last 3 days)0.10.20.4-0.60.1
Intermittent access total infusions0.20.30.4-0.6-0.4
Intermittent access day 1 locomotion0.40.50.9-0.3-1.0
Intermittent access day 15 total locomotion0.00.10.1-0.2-0.3
Intermittent access total locomotion0.50.61.2-0.0-1.1
Intermittent access standard deviation0.00.00.0-0.1-0.1
Left kidney weight1.46.37.12.3-2.7
Right kidney weight2.712.415.83.0-4.0
Cocaine induced anxiety0.81.11.90.5-1.4
Post-drug Anxiety0.00.00.10.1-0.3
Baseline Anxiety1.31.52.7-0.61.6
Tail length1.24.75.52.0-2.3
Length with tail3.113.715.83.4-4.0
Length without tail2.57.98.12.8-2.8
Times rat made contact with spout0.00.00.0-0.10.2
Lifetime Intake0.20.30.6-0.2-0.7
Liver weight, left0.71.11.81.4-0.6
Liver weight, right2.44.15.41.7-2.3
Locomotor activity3.45.37.42.7-1.8
Locomotor testing distance0.61.12.11.5-0.3
Locomotor testing rearing0.61.11.61.2-0.9
Locomotion in novel chamber0.60.80.80.9-0.8
Locomotion in novel chamber post-restriction1.42.33.41.9-1.1
Fecal boli incidents, locomotor time 10.71.11.3-1.10.9
Change in fecal boli incidents, locomotor task0.40.40.7-0.80.4
Time >=10cm from walls, locomotor time 10.30.40.7-0.80.2
Bouts of movement, locomotor time 10.00.00.0-0.1-0.1
Total resting periods, locomotor time 10.10.20.2-0.50.3
Rest time, locomotor task time 10.60.80.8-0.90.9
Distance moved, locomotor task time 10.00.00.0-0.2-0.0
Vertical activity count, locomotor time 10.40.91.11.1-0.8
Time >=10cm from walls, locomotor time 21.72.43.8-1.02.0
Bouts of movement, locomotor time 20.30.50.70.9-0.5
Total resting periods, locomotor time 20.20.40.50.7-0.5
Rest time, locomotor task time 20.30.40.70.3-0.8
Distance moved, locomotor task time 21.01.21.7-0.81.3
Vertical activity count, locomotor time 20.20.30.40.50.6
Light reinforcement 10.20.51.0-1.00.0
Light reinforcement 21.62.54.3-2.10.8
Bone: marrow area0.40.81.5-1.20.2
Bone: maximum diameter1.83.33.61.7-1.9
Bone: maximum force8.114.315.73.6-4.0
Bone: maximum moment6.110.611.83.1-3.4
Mean time between licks in bursts1.53.74.41.7-2.1
Mean num. licks in bursts0.10.10.10.3-0.4
Cd content in liver0.00.00.0-0.00.1
Co content in liver0.00.00.00.2-0.1
Cu content in liver0.50.61.21.10.1
Fe content in liver1.11.41.7-1.31.0
K content in liver3.43.23.6-1.71.9
Mg content in liver0.20.20.3-0.40.6
Mn content in liver0.30.30.40.6-0.4
Na content in liver0.40.50.9-0.20.9
Rb content in liver0.50.50.8-0.90.5
Se content in liver0.00.10.10.30.1
Sr content in liver0.30.20.4-0.70.2
Zn content in liver0.10.10.20.2-0.4
Bone: minimum diameter2.34.15.41.7-2.3
Time in familiar zone, hab. session 10.30.30.50.1-0.7
Time in novel zone, hab. session 10.10.10.2-0.10.5
Total zone transitions, hab. session 10.00.10.10.3-0.2
Total locomotion distance, hab. session 10.10.10.20.4-0.0
Locomotion velocity, hab. session 10.00.10.10.3-0.1
Time in familiar zone, hab. session 20.00.00.1-0.0-0.3
Time in novel zone, hab. session 20.20.20.2-0.50.5
Total zone transitions, hab. session 20.00.00.00.20.1
Total locomotion distance, hab. session 20.60.81.51.2-0.4
Locomotion velocity, hab. session 20.60.81.51.2-0.4
Novel to familiar place preference ratio0.60.61.1-1.00.4
Novelty place preference0.80.91.4-1.20.6
Time in novel zone, NPP test1.11.11.7-1.30.8
Total zone transitions, NPP test0.10.20.40.60.1
Total locomotion distance, NPP test0.30.40.80.90.2
Locomotion velocity, NPP test0.20.30.50.70.3
Intraocular pressure0.10.10.10.3-0.4
Delta distance traveled before/after self-admin1.31.42.00.9-1.4
Delta ambulatory time before/after self-admin0.30.40.50.5-0.7
Parametrial fat weight0.51.22.3-0.3-1.5
Pavlov. Cond. lever latency5.67.19.9-3.22.1
Pavlov. Cond. magazine entry latency0.40.50.70.8-0.7
Pavlov. Cond. change in total contacts4.75.06.32.5-1.9
Pavlov. Cond. index score2.53.14.42.1-1.4
Pavlov. Cond. latency score3.34.26.02.4-1.5
Pavlov. Cond. lever contacts5.26.28.12.8-2.1
Pavlov. Cond. magazine entry number0.81.01.2-1.10.9
Pavlov. Cond. intertrial magazine entries0.70.91.81.30.1
Pavlov. Cond. lever-magazine prob. diff.2.02.53.51.9-1.2
Pavlov. Cond. response bias1.82.22.91.7-1.2
Pavlov. Cond. lever latency1.11.52.1-1.01.4
Pavlov. Cond. magazine entry latency0.70.81.20.6-1.1
Pavlov. Cond. change in total contacts1.01.61.91.2-1.4
Pavlov. Cond. index score1.31.72.31.0-1.5
Pavlov. Cond. latency score0.91.21.60.9-1.3
Pavlov. Cond. lever contacts1.01.41.91.0-1.4
Pavlov. Cond. magazine entry number1.72.13.0-1.11.7
Pavlov. Cond. intertrial magazine entries0.60.90.9-1.01.0
Pavlov. Cond. lever-magazine prob. diff.1.52.02.71.2-1.6
Pavlov. Cond. response bias1.41.82.71.0-1.6
Time in closed arm before self-admin4.25.36.52.0-2.5
Time in closed arm after self-admin0.30.40.7-0.2-0.8
Time in open arm before self-admin0.40.50.80.9-0.4
Time in open arm after self-admin1.82.03.92.0-0.4
Bone: periosteal estimation1.22.63.41.3-1.9
Bone: periosteal perimeter3.05.26.22.0-2.5
Bone: post-yield work0.00.00.00.00.0
Progressive ratio test 1 active lever presses1.72.13.40.9-1.8
Progressive ratio test 1 breakpoint1.51.93.00.9-1.7
Progressive ratio test 1 inactive lever presses1.01.41.81.0-1.4
Progressive ratio test 2 active lever presses0.10.20.2-0.5-0.3
Progressive ratio test 2 breakpoint0.10.10.3-0.5-0.2
Progressive ratio test 2 inactive lever presses0.30.40.70.4-0.8
Incentive Sensitization - Responses1.72.43.4-1.81.2
Incentive Sensitization - Breakpoint2.33.04.0-2.01.4
Sum of active levers in priming session hrs 5-61.71.62.9-0.61.7
Progressive ratio0.40.60.7-0.70.8
Food seeking constrained by brief footshock0.70.91.5-0.61.2
Seeking ratio, punishment vs. effort0.10.10.20.40.1
Retroperitoneal fat weight1.35.68.01.8-2.8
Reaction time number correct1.42.73.41.9-1.4
Reaction time mean minus median0.10.10.30.1-0.5
Reaction time mean minus median AUC0.10.20.30.1-0.6
Reaction time num false alarms0.40.61.00.4-1.0
Reaction time num false alarms AUC0.20.30.50.2-0.7
Reaction time trials correct on left1.42.73.41.9-1.4
Reaction time trials on left1.63.03.61.9-1.6
Reaction time mean0.40.61.3-1.1-0.2
Reaction time mean AUC0.71.12.2-1.50.2
Median of all reaction times0.91.32.5-1.60.3
Reaction time omissions1.72.44.50.5-2.1
Reaction time false alarm rate0.10.10.1-0.4-0.2
Reaction time premature initiation rate0.60.81.21.1-0.6
Reaction time premature initiations1.73.03.82.0-1.5
Std. dev. reaction times0.40.81.50.2-1.2
Reaction time trials completed1.63.03.61.9-1.6
Reaction time trials AUC1.52.93.41.8-1.5
Run reversals in cocaine runway, females1.91.92.90.9-1.7
Run reversals in cocaine runway, males0.10.10.1-0.30.4
Latency to leave start box in cocaine runway0.00.00.0-0.2-0.0
Latency to leave start box in cocaine runway, F0.50.50.70.6-0.8
Latency to leave start box in cocaine runway, M2.72.63.2-1.81.4
Std. dev. time between licks in bursts1.52.12.71.2-1.7
Total sessions with >9 infusions1.82.13.41.0-1.8
Short access day 1 total inactive lever presses0.10.10.2-0.50.3
Short access day 10 total inactive lever presses0.00.10.2-0.20.4
Short access day 1 total infusions1.62.12.61.2-1.6
Short access day 10 total infusions0.10.20.20.3-0.4
Short access total infusions0.40.50.90.2-1.0
Short access day 1 locomotion1.62.03.01.0-1.7
Short access day 10 total locomotion3.05.66.02.4-2.3
Short access total locomotion1.92.32.91.3-1.7
One hour access (0.3 mA shock)0.40.50.5-0.70.7
Compulsive drug intake2.42.83.2-1.61.8
One hour access (shock baseline)0.40.61.00.4-1.0
Social response proportion2.42.73.71.9-1.3
Social responses1.92.44.12.0-0.9
Social time0.50.71.41.2-0.1
Soleus weight0.20.61.0-0.4-1.0
Bone: stiffness5.89.510.23.0-3.2
Tibialis anterior weight1.34.45.32.3-1.9
Time to tail flick, vehicle, before self-admin1.01.01.6-1.30.7
Time to tail flick, vehicle, after self-admin0.10.20.20.4-0.5
Time to tail flick, test, before self-admin0.50.60.80.6-0.9
Time to tail flick, test, after self-admin3.63.74.0-2.01.8
Delta time to tail flick, vehicle, before/after SA0.60.51.01.0-0.4
Delta time to tail flick, test, before/after SA2.32.32.3-1.51.5
Tibia length0.92.63.01.7-1.5
Ambulatory time before self-admin2.03.13.71.6-1.9
Ambulatory time after self-admin5.96.97.92.4-2.8
Bone: tissue strength0.40.40.70.2-0.8
Total heroin consumption0.30.40.7-0.1-0.8
Bone: trabecular number1.83.03.51.9-1.6
Bone: trabecular spacing0.60.81.2-1.10.6
Bone: trabecular thickness2.02.53.31.8-1.3
Bone: trabecular tissue density0.00.00.10.2-0.2
Water consumed over 24 hours0.60.80.91.0-0.9
Number of responses in last shaping day0.30.30.40.7-0.4