Hub : Genes

Cblc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Cblc 0.26 0.12 0.0e+00 0.25 0.27 0.27 0.27 1.0e-27 6.0e-30 1.8e-30 8.1e-30
2 LHb gene expression Cblc 0.66 0.15 3.4e-13 0.49 0.49 0.52 0.52 2.2e-13 2.2e-13 1.4e-14 2.6e-14
3 Liver gene expression Cblc 0.5 0.16 4.6e-08 0.06 0.08 0.07 0.06 4.2e-07 7.7e-09 2.1e-08 3.0e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.00.1-0.2-0.2-0.2
Area under the delay curve1.93.03.91.61.62.0
BMI with tail0.51.62.4-1.5-1.6-0.5
BMI without tail0.21.31.7-1.3-1.3-0.7
Body weight1.04.45.4-2.2-2.3-1.8
Weight adjusted by age0.00.00.0-0.00.10.1
Bone surface0.30.70.8-0.8-0.9-0.8
Bone volume0.30.60.8-0.6-0.7-0.9
Breakpoint value in progressive ratio session1.52.72.91.61.71.6
Number of licking bursts1.23.65.3-1.8-1.5-2.3
Context. condit. distance diff. score0.10.10.2-0.4-0.4-0.1
Locomotion velocity, session 10.10.10.10.40.30.1
Locomotion distance, session 10.20.30.6-0.3-0.4-0.8
Locomotion velocity, session 21.21.42.3-1.1-0.9-1.5
Locomotion distance, session 20.50.71.1-0.8-0.7-1.1
Locomotion velocity, session 30.20.20.3-0.5-0.4-0.4
Locomotion distance, session 30.70.70.90.81.00.9
Stereotopy head waving bouts, day 30.50.61.0-1.0-0.8-0.2
Stereotopy head waving duration, day 30.70.91.4-1.2-1.0-0.4
Locomotion velocity, session 70.10.10.10.00.30.4
Locomotion distance, session 70.10.10.1-0.4-0.30.2
Stereotopy head waving bouts, day 70.91.11.2-1.1-1.1-0.9
Stereotopy head waving duration, day 70.60.80.9-0.9-1.0-0.8
Locomotion velocity, session 80.00.00.00.10.20.0
Locomotion distance, session 80.10.10.2-0.3-0.3-0.5
Degree of sensitization distance0.40.50.8-0.7-0.9-0.3
Degree of sensitization stereotypy1.11.21.3-1.1-1.1-1.1
Conditioned locomotion0.00.00.1-0.20.20.1
Cocaine response after cond. corrected0.60.91.4-1.2-0.9-0.7
Cocaine response after cond. not corrected1.52.23.1-1.8-1.5-1.1
Cocaine response before conditioning1.51.82.1-1.4-1.4-1.2
Saline control response2.02.73.4-1.5-1.6-1.8
Bone: connectivity density0.00.00.00.1-0.1-0.0
Bone: cortical apparent density0.10.10.10.40.30.3
Bone: cortical area1.52.43.2-1.4-1.4-1.8
Bone: cortical porosity0.20.20.40.50.60.3
Bone: cortical porosity0.00.00.10.00.20.1
Bone: cortical thickness0.61.01.3-1.0-0.9-1.1
Bone: cortical thickness1.61.92.1-1.4-1.3-1.4
Bone: cortical tissue density0.10.20.20.50.40.5
Condit. Reinf. active minus inactive responses0.50.50.7-0.8-0.8-0.4
Condit. Reinf. active-inactive response ratio0.50.50.8-0.8-0.9-0.3
Condit. Reinf. active responses0.30.40.6-0.8-0.7-0.3
Condit. Reinf. inactive responses0.00.00.0-0.0-0.00.1
Incentive salience index mean0.30.40.4-0.7-0.6-0.6
Condit. Reinf. lever presses0.10.20.4-0.3-0.1-0.6
Condit. Reinf. active minus inactive responses0.10.20.3-0.5-0.4-0.1
Condit. Reinf. active-inactive response ratio0.50.81.3-1.2-0.9-0.5
Condit. Reinf. active responses0.10.20.30.30.30.5
Condit. Reinf. inactive responses0.81.31.61.31.01.1
Condit. Reinf. lever presses0.10.20.4-0.5-0.6-0.0
Condit. Reinf. lever reinforcers received0.10.20.30.30.30.5
Conditioned reinforcement - actives0.52.12.9-1.5-1.7-1.0
Conditioned reinforcement - inactives0.10.30.4-0.6-0.6-0.4
Conditioned locomotion2.03.03.6-1.9-1.9-1.4
Patch foraging indifference point 0 sec0.30.71.0-0.8-0.8-1.0
Patch foraging indifference point AUC1.63.74.0-1.9-1.9-2.0
Delay disc. indifference point, 0s delay1.31.51.61.11.21.3
Delay disc. indifference point, 16s delay1.31.82.11.31.21.5
Delay disc. indifference point, 2s delay4.95.46.02.32.22.5
Delay disc. indifference point, 24s delay0.10.20.2-0.5-0.30.4
Delay disc. indifference point, 4s delay0.20.20.50.00.10.7
Delay disc. indifference point, 8s delay1.62.62.91.61.51.7
Indifference point function ln k0.31.01.21.01.10.9
Indifference point function log k0.31.01.21.01.10.9
Patch foraging total patch changes 0 sec0.51.31.8-1.1-1.0-1.3
Patch foraging total patch changes 12 sec1.21.61.9-1.4-1.2-1.2
Patch foraging total patch changes 18 sec1.33.23.6-1.7-1.9-1.8
Patch foraging total patch changes 24 sec0.10.50.7-0.8-0.8-0.5
Patch foraging total patch changes 6 sec2.13.53.9-1.8-1.8-2.0
Patch foraging time to switch 0 sec1.45.56.42.52.32.2
Patch foraging water rate 0 sec1.66.27.3-2.7-2.5-2.2
Patch foraging water rate 12 sec0.10.30.5-0.6-0.7-0.4
Patch foraging water rate 18 sec0.10.20.3-0.4-0.5-0.5
Patch foraging water rate 24 sec0.60.81.0-0.9-1.0-0.8
Patch foraging water rate 6 sec0.81.21.4-1.0-1.2-1.0
Seeking ratio, delayed vs. immediate footshock1.42.02.21.31.41.5
Distance traveled before self-admin0.10.20.4-0.3-0.3-0.6
Distance traveled after self-admin0.10.20.30.60.50.1
Extensor digitorum longus weight1.97.510.1-2.4-2.6-3.2
Bone: elastic displacement0.81.01.11.11.01.0
Bone: elastic work0.00.00.1-0.3-0.2-0.1
Bone: endosteal estimation0.00.00.10.10.10.4
Bone: endosteal perimeter0.00.00.00.20.0-0.0
Epididymis fat weight0.21.01.41.21.10.7
Delta time in closed arm before/after self-admin0.10.10.20.30.10.4
Delta time in open arm before/after self-admin0.00.00.10.20.20.0
Diff in mean of infusions in LGA sessions0.91.61.71.31.21.3
Delay discount exponential model param1.62.23.1-1.4-1.3-1.8
Extinction: sum of active levers before priming0.00.10.10.10.30.2
Active lever presses in extinction session 60.10.10.2-0.5-0.2-0.3
Bone: final force0.30.50.7-0.9-0.7-0.6
Bone: final moment0.50.81.0-1.0-0.9-0.7
Food consumed during 24 hour testing period3.06.17.32.52.22.7
Glucose0.81.22.80.60.71.7
Heart weight1.93.13.7-1.9-1.7-1.6
Delay discount hyperbolic model param1.62.12.9-1.3-1.3-1.7
Intermittent access intake day 1-15 change0.00.20.3-0.3-0.6-0.2
Intermittent access intake escalation0.00.20.5-0.5-0.7-0.2
Intermittent access intake escalation 20.00.00.1-0.3-0.20.1
Intermitt. access day 1 inactive lever presses0.00.00.10.10.10.2
Intermitt. access day 15 inactive lever presses0.00.00.10.3-0.00.2
Intermitt. access escalation Index0.10.20.30.60.50.1
Intermittent access day 1 total infusions0.51.62.2-1.3-1.5-0.8
Intermittent access day 15 total infusions0.30.81.4-0.9-1.2-0.3
Intermittent access terminal intake (last 3 days)0.61.11.8-1.1-1.4-0.6
Intermittent access total infusions1.92.23.2-1.6-1.8-0.9
Intermittent access day 1 locomotion0.20.40.6-0.8-0.7-0.2
Intermittent access day 15 total locomotion0.00.20.4-0.4-0.6-0.1
Intermittent access total locomotion1.31.62.4-1.4-1.5-0.6
Intermittent access standard deviation0.10.40.90.40.40.9
Left kidney weight3.427.429.7-5.4-5.2-5.0
Right kidney weight3.524.727.0-5.2-5.0-4.7
Cocaine induced anxiety0.30.71.00.80.71.0
Post-drug Anxiety0.20.20.30.50.40.4
Baseline Anxiety0.00.10.20.0-0.1-0.4
Tail length0.21.11.3-1.0-1.0-1.2
Length with tail0.31.51.8-1.1-1.2-1.3
Length without tail0.31.61.9-1.2-1.4-1.1
Times rat made contact with spout0.00.10.1-0.4-0.2-0.0
Lifetime Intake1.72.13.0-1.6-1.7-0.9
Liver weight, left1.83.13.3-1.7-1.7-1.8
Liver weight, right1.22.12.5-1.5-1.6-1.2
Locomotor activity1.92.94.2-1.5-1.5-2.0
Locomotor testing distance0.71.72.4-1.2-1.1-1.5
Locomotor testing rearing2.17.68.1-2.8-2.8-2.6
Locomotion in novel chamber0.10.20.20.50.50.2
Locomotion in novel chamber post-restriction0.41.21.51.21.20.9
Fecal boli incidents, locomotor time 10.00.00.0-0.2-0.1-0.2
Change in fecal boli incidents, locomotor task1.11.21.41.21.01.1
Time >=10cm from walls, locomotor time 10.10.10.1-0.2-0.20.4
Bouts of movement, locomotor time 12.22.93.21.81.51.8
Total resting periods, locomotor time 13.43.94.32.11.82.1
Rest time, locomotor task time 10.20.30.40.70.50.6
Distance moved, locomotor task time 10.20.71.0-1.0-0.6-0.9
Vertical activity count, locomotor time 10.00.10.1-0.20.2-0.3
Time >=10cm from walls, locomotor time 20.10.30.80.10.20.9
Bouts of movement, locomotor time 21.86.06.32.52.52.4
Total resting periods, locomotor time 21.35.15.62.42.32.1
Rest time, locomotor task time 20.10.10.20.40.2-0.4
Distance moved, locomotor task time 20.81.11.7-1.3-0.9-0.8
Vertical activity count, locomotor time 20.00.10.2-0.10.40.4
Light reinforcement 10.00.20.4-0.6-0.50.1
Light reinforcement 20.10.10.2-0.4-0.2-0.4
Bone: marrow area0.00.00.10.00.00.3
Bone: maximum diameter2.14.35.3-1.9-2.0-2.3
Bone: maximum force0.10.20.3-0.5-0.5-0.3
Bone: maximum moment0.20.30.4-0.6-0.6-0.4
Mean time between licks in bursts0.00.10.10.10.20.4
Mean num. licks in bursts1.13.15.01.51.42.2
Cd content in liver0.00.00.1-0.1-0.20.3
Co content in liver1.01.21.31.01.11.1
Cu content in liver0.50.61.5-0.5-0.4-1.2
Fe content in liver4.65.79.3-1.8-2.1-3.1
K content in liver0.30.20.7-0.20.0-0.8
Mg content in liver0.40.40.6-0.7-0.4-0.8
Mn content in liver1.11.32.4-1.5-1.0-0.7
Na content in liver0.10.20.4-0.3-0.2-0.6
Rb content in liver0.30.30.5-0.4-0.5-0.7
Se content in liver3.33.95.5-1.9-1.6-2.3
Sr content in liver0.00.00.0-0.00.1-0.1
Zn content in liver0.91.11.3-1.0-0.9-1.2
Bone: minimum diameter0.10.30.3-0.5-0.6-0.4
Time in familiar zone, hab. session 10.10.20.2-0.5-0.4-0.2
Time in novel zone, hab. session 10.40.40.7-0.8-0.8-0.2
Total zone transitions, hab. session 10.30.40.5-0.6-0.7-0.6
Total locomotion distance, hab. session 10.40.50.80.90.70.5
Locomotion velocity, hab. session 11.11.62.21.51.21.0
Time in familiar zone, hab. session 20.10.10.2-0.2-0.4-0.5
Time in novel zone, hab. session 20.20.20.6-0.10.10.8
Total zone transitions, hab. session 20.60.70.9-0.9-0.7-1.0
Total locomotion distance, hab. session 20.40.60.70.80.90.6
Locomotion velocity, hab. session 20.30.30.50.60.70.4
Novel to familiar place preference ratio1.01.31.7-1.2-1.3-0.8
Novelty place preference0.91.11.5-1.2-1.2-0.7
Time in novel zone, NPP test1.11.31.8-1.3-1.4-0.5
Total zone transitions, NPP test0.30.41.1-0.3-0.3-1.0
Total locomotion distance, NPP test0.20.30.7-0.3-0.5-0.8
Locomotion velocity, NPP test0.40.61.5-0.2-0.4-1.2
Intraocular pressure0.10.10.3-0.1-0.10.6
Delta distance traveled before/after self-admin2.02.22.31.51.51.4
Delta ambulatory time before/after self-admin0.30.60.70.70.80.8
Parametrial fat weight0.10.10.3-0.5-0.3-0.2
Pavlov. Cond. lever latency0.81.01.61.00.81.3
Pavlov. Cond. magazine entry latency0.10.20.2-0.4-0.4-0.5
Pavlov. Cond. change in total contacts0.30.30.40.50.60.6
Pavlov. Cond. index score0.40.50.8-0.7-0.5-0.9
Pavlov. Cond. latency score0.10.20.4-0.4-0.2-0.6
Pavlov. Cond. lever contacts0.60.71.4-0.7-0.6-1.2
Pavlov. Cond. magazine entry number0.00.00.10.30.10.2
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.6-0.40.1
Pavlov. Cond. lever-magazine prob. diff.0.50.60.8-0.8-0.6-0.9
Pavlov. Cond. response bias1.21.51.9-1.2-1.1-1.4
Pavlov. Cond. lever latency0.00.00.10.20.20.0
Pavlov. Cond. magazine entry latency0.30.50.7-0.6-0.80.6
Pavlov. Cond. change in total contacts0.10.31.00.10.21.0
Pavlov. Cond. index score0.10.20.5-0.2-0.30.7
Pavlov. Cond. latency score0.10.20.6-0.1-0.20.8
Pavlov. Cond. lever contacts0.10.10.2-0.4-0.4-0.2
Pavlov. Cond. magazine entry number0.50.72.0-0.20.0-1.4
Pavlov. Cond. intertrial magazine entries0.10.20.60.30.3-0.8
Pavlov. Cond. lever-magazine prob. diff.0.10.20.3-0.4-0.50.5
Pavlov. Cond. response bias0.10.10.2-0.3-0.30.4
Time in closed arm before self-admin0.71.31.4-1.1-1.1-1.2
Time in closed arm after self-admin0.91.01.31.00.81.1
Time in open arm before self-admin1.01.21.71.01.01.3
Time in open arm after self-admin0.10.10.30.30.50.2
Bone: periosteal estimation0.20.50.6-0.8-0.7-0.7
Bone: periosteal perimeter0.20.40.6-0.4-0.6-0.8
Bone: post-yield work0.61.11.41.21.01.0
Progressive ratio test 1 active lever presses1.62.83.0-1.6-1.7-1.7
Progressive ratio test 1 breakpoint1.42.52.6-1.5-1.6-1.5
Progressive ratio test 1 inactive lever presses0.51.31.7-1.2-1.3-0.8
Progressive ratio test 2 active lever presses1.31.92.6-1.3-1.6-1.2
Progressive ratio test 2 breakpoint1.72.12.9-1.4-1.7-1.3
Progressive ratio test 2 inactive lever presses0.00.10.1-0.0-0.4-0.2
Incentive Sensitization - Responses0.41.11.6-1.0-1.3-0.8
Incentive Sensitization - Breakpoint0.41.01.4-0.9-1.2-0.8
Sum of active levers in priming session hrs 5-60.30.30.40.40.60.7
Progressive ratio0.72.12.71.61.31.3
Food seeking constrained by brief footshock4.55.66.22.12.52.5
Seeking ratio, punishment vs. effort0.20.50.70.40.80.8
Retroperitoneal fat weight0.00.00.1-0.1-0.2-0.3
Reaction time number correct1.76.28.2-2.9-2.7-1.7
Reaction time mean minus median0.00.00.1-0.00.00.3
Reaction time mean minus median AUC0.10.40.6-0.7-0.7-0.4
Reaction time num false alarms3.96.67.1-2.7-2.6-2.4
Reaction time num false alarms AUC2.45.56.0-2.5-2.3-2.3
Reaction time trials correct on left1.76.28.2-2.9-2.7-1.7
Reaction time trials on left1.86.28.3-2.9-2.7-1.7
Reaction time mean0.61.42.80.70.91.7
Reaction time mean AUC0.40.91.60.60.81.3
Median of all reaction times1.21.93.60.91.11.9
Reaction time omissions0.10.20.4-0.6-0.20.4
Reaction time false alarm rate0.20.30.6-0.4-0.5-0.7
Reaction time premature initiation rate0.20.30.40.60.60.4
Reaction time premature initiations0.20.60.8-0.9-0.7-0.7
Std. dev. reaction times0.00.10.30.10.30.6
Reaction time trials completed1.86.28.3-2.9-2.7-1.7
Reaction time trials AUC2.27.610.3-3.2-3.0-1.9
Run reversals in cocaine runway, females0.30.30.50.60.70.3
Run reversals in cocaine runway, males0.50.60.7-0.9-0.7-0.6
Latency to leave start box in cocaine runway0.10.10.3-0.2-0.5-0.3
Latency to leave start box in cocaine runway, F0.81.01.1-0.9-1.0-1.1
Latency to leave start box in cocaine runway, M0.10.10.20.40.10.5
Std. dev. time between licks in bursts0.00.10.1-0.2-0.3-0.3
Total sessions with >9 infusions3.23.94.5-2.1-2.1-1.7
Short access day 1 total inactive lever presses0.20.50.5-0.7-0.7-0.6
Short access day 10 total inactive lever presses0.21.41.81.01.31.2
Short access day 1 total infusions1.12.22.4-1.5-1.5-1.4
Short access day 10 total infusions2.23.74.5-2.1-2.1-1.5
Short access total infusions1.52.12.5-1.6-1.6-1.1
Short access day 1 locomotion2.13.64.5-2.1-2.0-1.5
Short access day 10 total locomotion0.00.20.4-0.6-0.30.2
Short access total locomotion0.71.01.7-1.3-1.1-0.5
One hour access (0.3 mA shock)0.00.00.10.0-0.30.1
Compulsive drug intake0.40.61.0-0.5-0.7-1.0
One hour access (shock baseline)0.41.01.5-1.1-1.2-0.5
Social response proportion1.21.52.4-1.6-1.3-0.6
Social responses0.81.11.3-1.1-1.1-0.8
Social time2.43.85.02.22.11.5
Soleus weight0.20.71.6-0.1-0.7-1.3
Bone: stiffness0.61.11.4-0.9-1.1-1.2
Tibialis anterior weight3.612.516.4-3.1-3.4-4.0
Time to tail flick, vehicle, before self-admin2.42.93.7-1.9-1.6-1.5
Time to tail flick, vehicle, after self-admin0.00.00.10.1-0.10.2
Time to tail flick, test, before self-admin0.30.30.50.30.70.6
Time to tail flick, test, after self-admin0.40.50.80.60.50.9
Delta time to tail flick, vehicle, before/after SA0.10.10.20.50.20.3
Delta time to tail flick, test, before/after SA0.40.60.9-0.6-0.9-0.7
Tibia length0.20.61.0-1.0-0.8-0.5
Ambulatory time before self-admin0.00.00.10.10.0-0.3
Ambulatory time after self-admin0.30.50.70.80.80.4
Bone: tissue strength0.90.91.70.70.81.3
Total heroin consumption0.00.00.0-0.10.1-0.0
Bone: trabecular number0.00.00.00.20.1-0.0
Bone: trabecular spacing0.00.00.0-0.1-0.2-0.2
Bone: trabecular thickness1.41.92.3-1.5-1.4-1.3
Bone: trabecular tissue density0.30.50.5-0.7-0.7-0.6
Water consumed over 24 hours0.10.20.5-0.40.20.7
Number of responses in last shaping day2.43.13.7-1.9-1.9-1.5