Cblc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Cblc	0.26	0.12	0.0e+00	0.25	0.27	0.27	0.27	1.0e-27	6.0e-30	1.7e-30	7.5e-30
2	LHb	gene expression	Cblc	0.66	0.15	3.4e-13	0.49	0.49	0.52	0.52	2.2e-13	2.2e-13	1.4e-14	2.7e-14
3	Liver	gene expression	Cblc	0.5	0.16	4.6e-08	0.06	0.08	0.07	0.06	4.2e-07	7.7e-09	1.8e-08	2.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.0	0.0	0.1	0.2	0.2	-0.2
Area under the delay curve	2.5	3.0	3.9	-1.6	-1.6	2.0
BMI with tail	0.5	1.6	2.4	1.5	1.6	-0.5
BMI without tail	0.4	1.3	1.7	1.3	1.3	-0.7
Body weight	1.0	4.4	5.4	2.2	2.3	-1.8
Weight adjusted by age	0.0	0.0	0.0	0.0	-0.1	0.1
Bone surface	0.4	0.7	0.8	0.8	0.9	-0.8
Bone volume	0.3	0.6	0.8	0.6	0.7	-0.9
Breakpoint value in progressive ratio session	2.2	2.7	2.9	-1.6	-1.7	1.6
Number of licking bursts	2.2	3.6	5.3	1.8	1.5	-2.3
Context. condit. distance diff. score	0.1	0.1	0.2	0.4	0.4	-0.1
Locomotion velocity, session 1	0.1	0.1	0.1	-0.4	-0.3	0.1
Locomotion distance, session 1	0.2	0.3	0.6	0.3	0.4	-0.8
Locomotion velocity, session 2	1.2	1.4	2.3	1.1	0.9	-1.5
Locomotion distance, session 2	0.5	0.7	1.1	0.8	0.7	-1.1
Locomotion velocity, session 3	0.2	0.2	0.3	0.5	0.4	-0.4
Locomotion distance, session 3	0.7	0.7	0.9	-0.8	-1.0	0.9
Stereotopy head waving bouts, day 3	0.5	0.6	1.0	1.0	0.8	-0.2
Stereotopy head waving duration, day 3	0.7	0.9	1.4	1.2	1.0	-0.4
Locomotion velocity, session 7	0.1	0.1	0.1	-0.0	-0.3	0.4
Locomotion distance, session 7	0.1	0.1	0.1	0.4	0.3	0.2
Stereotopy head waving bouts, day 7	1.0	1.1	1.2	1.1	1.1	-0.9
Stereotopy head waving duration, day 7	0.6	0.8	0.9	0.9	1.0	-0.8
Locomotion velocity, session 8	0.0	0.0	0.0	-0.1	-0.2	0.0
Locomotion distance, session 8	0.1	0.1	0.2	0.3	0.3	-0.5
Degree of sensitization distance	0.5	0.5	0.8	0.7	0.9	-0.3
Degree of sensitization stereotypy	1.1	1.2	1.3	1.1	1.1	-1.1
Conditioned locomotion	0.0	0.0	0.1	0.2	-0.2	0.1
Cocaine response after cond. corrected	0.7	0.9	1.4	1.2	0.9	-0.7
Cocaine response after cond. not corrected	1.8	2.2	3.1	1.8	1.5	-1.1
Cocaine response before conditioning	1.5	1.8	2.1	1.4	1.4	-1.2
Saline control response	2.1	2.7	3.4	1.5	1.6	-1.8
Bone: connectivity density	0.0	0.0	0.0	-0.1	0.1	-0.0
Bone: cortical apparent density	0.1	0.1	0.1	-0.4	-0.3	0.3
Bone: cortical area	1.6	2.4	3.2	1.4	1.4	-1.8
Bone: cortical porosity	0.2	0.2	0.4	-0.5	-0.6	0.3
Bone: cortical porosity	0.0	0.0	0.1	-0.0	-0.2	0.1
Bone: cortical thickness	0.6	1.0	1.3	1.0	0.9	-1.1
Bone: cortical thickness	1.6	1.9	2.1	1.4	1.3	-1.4
Bone: cortical tissue density	0.1	0.2	0.2	-0.5	-0.4	0.5
Condit. Reinf. active minus inactive responses	0.5	0.5	0.7	0.8	0.8	-0.4
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	0.8	0.9	-0.3
Condit. Reinf. active responses	0.3	0.4	0.6	0.8	0.7	-0.3
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.0	0.0	0.1
Incentive salience index mean	0.3	0.4	0.4	0.7	0.6	-0.6
Condit. Reinf. lever presses	0.1	0.2	0.4	0.3	0.1	-0.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.5	0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.3	1.2	0.9	-0.5
Condit. Reinf. active responses	0.1	0.2	0.3	-0.3	-0.3	0.5
Condit. Reinf. inactive responses	1.0	1.3	1.6	-1.3	-1.0	1.1
Condit. Reinf. lever presses	0.1	0.2	0.4	0.5	0.6	-0.0
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	-0.3	-0.3	0.5
Conditioned reinforcement - actives	1.2	2.1	2.9	1.5	1.7	-1.0
Conditioned reinforcement - inactives	0.2	0.3	0.4	0.6	0.6	-0.4
Conditioned locomotion	2.3	3.0	3.6	1.9	1.9	-1.4
Patch foraging indifference point 0 sec	0.4	0.7	1.0	0.8	0.8	-1.0
Patch foraging indifference point AUC	2.6	3.7	4.0	1.9	1.9	-2.0
Delay disc. indifference point, 0s delay	1.3	1.5	1.6	-1.1	-1.2	1.3
Delay disc. indifference point, 16s delay	1.6	1.8	2.1	-1.3	-1.2	1.5
Delay disc. indifference point, 2s delay	4.9	5.4	6.0	-2.3	-2.2	2.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.2	0.5	0.3	0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.0	-0.1	0.7
Delay disc. indifference point, 8s delay	2.2	2.6	2.9	-1.6	-1.5	1.7
Indifference point function ln k	0.6	1.0	1.2	-1.0	-1.1	0.9
Indifference point function log k	0.6	1.0	1.2	-1.0	-1.1	0.9
Patch foraging total patch changes 0 sec	0.7	1.3	1.8	1.1	1.0	-1.3
Patch foraging total patch changes 12 sec	1.2	1.6	1.9	1.4	1.2	-1.2
Patch foraging total patch changes 18 sec	2.1	3.2	3.6	1.7	1.9	-1.8
Patch foraging total patch changes 24 sec	0.3	0.5	0.7	0.8	0.8	-0.5
Patch foraging total patch changes 6 sec	2.3	3.5	3.9	1.8	1.8	-2.0
Patch foraging time to switch 0 sec	2.7	5.5	6.4	-2.5	-2.3	2.2
Patch foraging water rate 0 sec	2.9	6.2	7.3	2.7	2.5	-2.2
Patch foraging water rate 12 sec	0.2	0.3	0.5	0.6	0.7	-0.4
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.4	0.5	-0.5
Patch foraging water rate 24 sec	0.6	0.8	1.0	0.9	1.0	-0.8
Patch foraging water rate 6 sec	0.8	1.2	1.4	1.0	1.2	-1.0
Seeking ratio, delayed vs. immediate footshock	1.6	2.0	2.2	-1.3	-1.4	1.5
Distance traveled before self-admin	0.2	0.2	0.4	0.2	0.3	-0.6
Distance traveled after self-admin	0.2	0.2	0.3	-0.6	-0.5	0.1
Extensor digitorum longus weight	1.9	7.5	10.1	2.4	2.6	-3.2
Bone: elastic displacement	0.9	1.0	1.1	-1.1	-1.0	1.0
Bone: elastic work	0.0	0.0	0.1	0.3	0.2	-0.1
Bone: endosteal estimation	0.0	0.0	0.1	-0.1	-0.1	0.4
Bone: endosteal perimeter	0.0	0.0	0.0	-0.2	-0.0	-0.0
Epididymis fat weight	0.3	1.0	1.4	-1.2	-1.1	0.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.3	-0.1	0.4
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.2	-0.2	0.0
Diff in mean of infusions in LGA sessions	1.3	1.6	1.7	-1.3	-1.2	1.3
Delay discount exponential model param	2.0	2.2	3.1	1.4	1.3	-1.8
Extinction: sum of active levers before priming	0.0	0.1	0.1	-0.1	-0.3	0.2
Active lever presses in extinction session 6	0.1	0.1	0.2	0.5	0.2	-0.3
Bone: final force	0.3	0.5	0.7	0.9	0.7	-0.6
Bone: final moment	0.5	0.8	1.0	1.0	0.9	-0.7
Food consumed during 24 hour testing period	4.4	6.1	7.3	-2.5	-2.2	2.7
Glucose	0.8	1.2	2.8	-0.6	-0.7	1.7
Heart weight	2.0	3.1	3.7	1.9	1.7	-1.6
Delay discount hyperbolic model param	1.9	2.1	2.9	1.3	1.3	-1.7
Intermittent access intake day 1-15 change	0.1	0.2	0.3	0.3	0.6	-0.2
Intermittent access intake escalation	0.1	0.2	0.5	0.5	0.7	-0.2
Intermittent access intake escalation 2	0.0	0.0	0.1	0.3	0.2	0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.1	-0.1	0.2
Intermitt. access day 15 inactive lever presses	0.0	0.0	0.1	-0.3	0.0	0.2
Intermitt. access escalation Index	0.1	0.2	0.3	-0.6	-0.5	0.1
Intermittent access day 1 total infusions	1.0	1.6	2.2	1.3	1.5	-0.8
Intermittent access day 15 total infusions	0.5	0.8	1.4	0.9	1.2	-0.3
Intermittent access terminal intake (last 3 days)	0.8	1.1	1.8	1.1	1.4	-0.6
Intermittent access total infusions	1.9	2.2	3.2	1.6	1.8	-0.9
Intermittent access day 1 locomotion	0.3	0.4	0.6	0.8	0.7	-0.2
Intermittent access day 15 total locomotion	0.1	0.2	0.4	0.4	0.6	-0.1
Intermittent access total locomotion	1.3	1.6	2.4	1.4	1.5	-0.6
Intermittent access standard deviation	0.2	0.4	0.9	-0.4	-0.4	0.9
Left kidney weight	5.9	27.4	29.7	5.4	5.2	-5.0
Right kidney weight	5.4	24.7	27.0	5.2	5.0	-4.7
Cocaine induced anxiety	0.5	0.7	1.0	-0.8	-0.7	1.0
Post-drug Anxiety	0.2	0.2	0.3	-0.5	-0.4	0.4
Baseline Anxiety	0.1	0.1	0.2	-0.0	0.1	-0.4
Tail length	0.3	1.1	1.3	1.0	1.0	-1.2
Length with tail	0.3	1.5	1.8	1.1	1.2	-1.3
Length without tail	0.5	1.6	1.9	1.2	1.4	-1.1
Times rat made contact with spout	0.0	0.1	0.1	0.4	0.2	-0.0
Lifetime Intake	1.7	2.1	3.0	1.6	1.7	-0.9
Liver weight, left	1.9	3.1	3.3	1.7	1.7	-1.8
Liver weight, right	1.2	2.1	2.5	1.5	1.6	-1.2
Locomotor activity	1.9	2.9	4.2	1.5	1.5	-2.0
Locomotor testing distance	0.9	1.7	2.4	1.2	1.1	-1.5
Locomotor testing rearing	3.8	7.6	8.1	2.8	2.8	-2.6
Locomotion in novel chamber	0.1	0.2	0.2	-0.5	-0.5	0.2
Locomotion in novel chamber post-restriction	0.7	1.2	1.5	-1.2	-1.2	0.9
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.2	0.1	-0.2
Change in fecal boli incidents, locomotor task	1.2	1.2	1.4	-1.2	-1.0	1.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	0.2	0.4
Bouts of movement, locomotor time 1	2.5	2.9	3.2	-1.8	-1.5	1.8
Total resting periods, locomotor time 1	3.5	3.9	4.3	-2.1	-1.8	2.1
Rest time, locomotor task time 1	0.3	0.3	0.4	-0.7	-0.5	0.6
Distance moved, locomotor task time 1	0.5	0.7	1.0	1.0	0.6	-0.9
Vertical activity count, locomotor time 1	0.0	0.1	0.1	0.2	-0.2	-0.3
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.8	-0.1	-0.2	0.9
Bouts of movement, locomotor time 2	3.8	6.0	6.3	-2.5	-2.5	2.4
Total resting periods, locomotor time 2	2.9	5.1	5.6	-2.4	-2.3	2.1
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	-0.2	-0.4
Distance moved, locomotor task time 2	0.9	1.1	1.7	1.3	0.9	-0.8
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.1	-0.4	0.4
Light reinforcement 1	0.1	0.2	0.4	0.6	0.5	0.1
Light reinforcement 2	0.1	0.1	0.2	0.4	0.2	-0.4
Bone: marrow area	0.0	0.0	0.1	-0.0	-0.0	0.3
Bone: maximum diameter	2.3	4.3	5.3	1.9	2.0	-2.3
Bone: maximum force	0.1	0.2	0.3	0.5	0.5	-0.3
Bone: maximum moment	0.2	0.3	0.4	0.6	0.6	-0.4
Mean time between licks in bursts	0.0	0.1	0.1	-0.1	-0.2	0.4
Mean num. licks in bursts	2.0	3.1	5.0	-1.5	-1.4	2.2
Cd content in liver	0.0	0.0	0.1	0.1	0.2	0.3
Co content in liver	1.0	1.2	1.3	-1.0	-1.1	1.1
Cu content in liver	0.5	0.6	1.5	0.5	0.4	-1.2
Fe content in liver	4.7	5.7	9.3	1.8	2.1	-3.1
K content in liver	0.3	0.2	0.7	0.2	-0.0	-0.8
Mg content in liver	0.4	0.4	0.6	0.7	0.4	-0.8
Mn content in liver	1.2	1.3	2.4	1.5	1.0	-0.7
Na content in liver	0.2	0.2	0.4	0.3	0.2	-0.6
Rb content in liver	0.3	0.3	0.5	0.4	0.5	-0.7
Se content in liver	3.3	3.9	5.5	1.9	1.6	-2.3
Sr content in liver	0.0	0.0	0.0	0.0	-0.1	-0.1
Zn content in liver	1.0	1.1	1.3	1.0	0.9	-1.2
Bone: minimum diameter	0.1	0.3	0.3	0.5	0.6	-0.4
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.5	0.4	-0.2
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.8	0.8	-0.2
Total zone transitions, hab. session 1	0.3	0.4	0.5	0.6	0.7	-0.6
Total locomotion distance, hab. session 1	0.4	0.5	0.8	-0.9	-0.7	0.5
Locomotion velocity, hab. session 1	1.1	1.6	2.2	-1.5	-1.2	1.0
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.2	0.4	-0.5
Time in novel zone, hab. session 2	0.2	0.2	0.6	0.1	-0.1	0.8
Total zone transitions, hab. session 2	0.6	0.7	0.9	0.9	0.7	-1.0
Total locomotion distance, hab. session 2	0.4	0.6	0.7	-0.8	-0.9	0.6
Locomotion velocity, hab. session 2	0.3	0.3	0.5	-0.6	-0.7	0.4
Novel to familiar place preference ratio	1.2	1.3	1.7	1.2	1.3	-0.8
Novelty place preference	1.1	1.1	1.5	1.2	1.2	-0.7
Time in novel zone, NPP test	1.2	1.3	1.8	1.3	1.4	-0.5
Total zone transitions, NPP test	0.3	0.4	1.1	0.3	0.3	-1.0
Total locomotion distance, NPP test	0.2	0.3	0.7	0.3	0.5	-0.8
Locomotion velocity, NPP test	0.4	0.6	1.5	0.2	0.4	-1.2
Intraocular pressure	0.1	0.1	0.3	0.1	0.1	0.6
Delta distance traveled before/after self-admin	2.1	2.2	2.3	-1.5	-1.5	1.4
Delta ambulatory time before/after self-admin	0.5	0.6	0.7	-0.7	-0.8	0.8
Parametrial fat weight	0.1	0.1	0.3	0.5	0.3	-0.2
Pavlov. Cond. lever latency	0.8	1.0	1.6	-1.0	-0.8	1.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	0.4	0.4	-0.5
Pavlov. Cond. change in total contacts	0.3	0.3	0.4	-0.5	-0.6	0.6
Pavlov. Cond. index score	0.4	0.5	0.8	0.7	0.5	-0.9
Pavlov. Cond. latency score	0.1	0.2	0.4	0.4	0.2	-0.6
Pavlov. Cond. lever contacts	0.6	0.7	1.4	0.7	0.6	-1.2
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.3	-0.1	0.2
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.6	0.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	0.8	0.6	-0.9
Pavlov. Cond. response bias	1.2	1.5	1.9	1.2	1.1	-1.4
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.2	-0.2	0.0
Pavlov. Cond. magazine entry latency	0.4	0.5	0.7	0.6	0.8	0.6
Pavlov. Cond. change in total contacts	0.2	0.3	1.0	-0.1	-0.2	1.0
Pavlov. Cond. index score	0.1	0.2	0.5	0.2	0.3	0.7
Pavlov. Cond. latency score	0.2	0.2	0.6	0.1	0.2	0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.4	0.4	-0.2
Pavlov. Cond. magazine entry number	0.5	0.7	2.0	0.2	-0.0	-1.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.6	-0.3	-0.3	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.3	0.4	0.5	0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	0.3	0.3	0.4
Time in closed arm before self-admin	1.0	1.3	1.4	1.1	1.1	-1.2
Time in closed arm after self-admin	0.9	1.0	1.3	-1.0	-0.8	1.1
Time in open arm before self-admin	1.1	1.2	1.7	-1.0	-1.0	1.3
Time in open arm after self-admin	0.1	0.1	0.3	-0.3	-0.5	0.2
Bone: periosteal estimation	0.3	0.5	0.6	0.8	0.7	-0.7
Bone: periosteal perimeter	0.2	0.4	0.6	0.4	0.6	-0.8
Bone: post-yield work	0.7	1.1	1.4	-1.2	-1.0	1.0
Progressive ratio test 1 active lever presses	2.3	2.8	3.0	1.6	1.7	-1.7
Progressive ratio test 1 breakpoint	2.0	2.5	2.6	1.5	1.6	-1.5
Progressive ratio test 1 inactive lever presses	0.9	1.3	1.7	1.2	1.3	-0.8
Progressive ratio test 2 active lever presses	1.6	1.9	2.6	1.3	1.6	-1.2
Progressive ratio test 2 breakpoint	1.9	2.1	2.9	1.4	1.7	-1.3
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.1	0.0	0.4	-0.2
Incentive Sensitization - Responses	0.8	1.1	1.6	1.0	1.3	-0.8
Incentive Sensitization - Breakpoint	0.7	1.0	1.4	0.9	1.2	-0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.4	-0.6	0.7
Progressive ratio	1.3	2.1	2.7	-1.6	-1.3	1.3
Food seeking constrained by brief footshock	4.6	5.7	6.2	-2.1	-2.5	2.5
Seeking ratio, punishment vs. effort	0.3	0.5	0.7	-0.4	-0.8	0.8
Retroperitoneal fat weight	0.0	0.0	0.1	0.1	0.2	-0.3
Reaction time number correct	3.2	6.2	8.2	2.9	2.7	-1.7
Reaction time mean minus median	0.0	0.0	0.1	0.0	0.0	0.3
Reaction time mean minus median AUC	0.2	0.4	0.6	0.7	0.7	-0.4
Reaction time num false alarms	4.7	6.6	7.1	2.7	2.6	-2.4
Reaction time num false alarms AUC	3.5	5.5	6.0	2.5	2.3	-2.3
Reaction time trials correct on left	3.2	6.2	8.2	2.9	2.7	-1.7
Reaction time trials on left	3.3	6.2	8.3	2.9	2.7	-1.7
Reaction time mean	0.9	1.4	2.8	-0.7	-0.9	1.7
Reaction time mean AUC	0.5	0.9	1.6	-0.6	-0.8	1.3
Median of all reaction times	1.4	1.9	3.6	-0.9	-1.1	1.9
Reaction time omissions	0.1	0.2	0.4	0.6	0.2	0.4
Reaction time false alarm rate	0.2	0.3	0.6	0.4	0.5	-0.7
Reaction time premature initiation rate	0.2	0.3	0.4	-0.6	-0.6	0.4
Reaction time premature initiations	0.3	0.6	0.8	0.9	0.7	-0.7
Std. dev. reaction times	0.1	0.1	0.3	-0.1	-0.3	0.6
Reaction time trials completed	3.3	6.2	8.3	2.9	2.7	-1.7
Reaction time trials AUC	4.0	7.6	10.3	3.2	3.0	-1.9
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.6	-0.7	0.3
Run reversals in cocaine runway, males	0.6	0.6	0.7	0.9	0.7	-0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.2	0.5	-0.3
Latency to leave start box in cocaine runway, F	0.8	1.0	1.1	0.9	1.0	-1.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.4	-0.1	0.5
Std. dev. time between licks in bursts	0.0	0.1	0.1	0.2	0.3	-0.3
Total sessions with >9 infusions	3.2	3.9	4.5	2.1	2.1	-1.7
Short access day 1 total inactive lever presses	0.4	0.5	0.5	0.7	0.7	-0.6
Short access day 10 total inactive lever presses	0.6	1.4	1.8	-1.0	-1.3	1.2
Short access day 1 total infusions	1.6	2.2	2.4	1.5	1.5	-1.4
Short access day 10 total infusions	2.9	3.7	4.5	2.1	2.1	-1.5
Short access total infusions	1.6	2.1	2.5	1.6	1.6	-1.1
Short access day 1 locomotion	2.9	3.6	4.5	2.1	2.0	-1.5
Short access day 10 total locomotion	0.1	0.2	0.4	0.6	0.3	0.2
Short access total locomotion	0.9	1.0	1.7	1.3	1.1	-0.5
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.0	0.3	0.1
Compulsive drug intake	0.5	0.6	1.0	0.5	0.7	-1.0
One hour access (shock baseline)	0.6	1.0	1.5	1.1	1.2	-0.5
Social response proportion	1.3	1.5	2.4	1.6	1.3	-0.6
Social responses	0.8	1.1	1.3	1.1	1.1	-0.8
Social time	2.8	3.8	5.0	-2.2	-2.1	1.5
Soleus weight	0.2	0.7	1.6	0.1	0.7	-1.3
Bone: stiffness	0.7	1.1	1.4	0.9	1.1	-1.2
Tibialis anterior weight	3.7	12.5	16.4	3.1	3.4	-4.0
Time to tail flick, vehicle, before self-admin	2.8	2.9	3.7	1.9	1.6	-1.5
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.1	0.1	0.2
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.3	-0.7	0.6
Time to tail flick, test, after self-admin	0.4	0.5	0.8	-0.6	-0.5	0.9
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.5	-0.2	0.3
Delta time to tail flick, test, before/after SA	0.5	0.6	0.9	0.6	0.9	-0.7
Tibia length	0.2	0.6	1.0	1.0	0.8	-0.5
Ambulatory time before self-admin	0.0	0.0	0.1	-0.1	-0.0	-0.3
Ambulatory time after self-admin	0.4	0.5	0.7	-0.8	-0.8	0.4
Bone: tissue strength	0.9	0.9	1.7	-0.7	-0.8	1.3
Total heroin consumption	0.0	0.0	0.0	0.1	-0.1	-0.0
Bone: trabecular number	0.0	0.0	0.0	-0.2	-0.1	-0.0
Bone: trabecular spacing	0.0	0.0	0.0	0.1	0.2	-0.2
Bone: trabecular thickness	1.5	1.9	2.3	1.5	1.4	-1.3
Bone: trabecular tissue density	0.3	0.5	0.5	0.7	0.7	-0.6
Water consumed over 24 hours	0.2	0.2	0.5	0.4	-0.2	0.7
Number of responses in last shaping day	2.8	3.1	3.7	1.9	1.9	-1.5