Casc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Casc3	0.04	0.03	3.9e-03	0.02	0.01	0.01	0.01	5.7e-03	1.4e-02	8.8e-02	1.8e-02
2	RMTg	mRNA stability	Casc3	0.48	0.16	1.9e-09	0.3	0.31	0.32	0.32	8.8e-09	7.7e-09	3.8e-09	3.8e-09
3	Liver	mRNA stability	Casc3	0.09	0.06	4.3e-11	0.09	0.08	0.09	0.1	1.3e-10	3.6e-09	1.8e-10	1.2e-10
4	NAcc	mRNA stability	Casc3	0.03	0.03	1.1e-03	0.01	0.02	0	0.01	8.6e-03	1.5e-03	1.1e-01	2.1e-02
5	pVTA	gene expression	Casc3	0.08	0.08	2.0e-03	0.03	0.04	0.05	0.03	1.1e-03	4.9e-04	1.2e-04	1.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.3	4.0	4.8	-1.9	2.2	-2.1	2.1	-1.8
Area under the delay curve	0.4	0.5	1.5	-1.2	0.7	-0.5	0.4	-0.1
BMI with tail	1.6	5.6	8.8	2.5	-2.8	3.0	-1.4	1.7
BMI without tail	0.9	2.7	5.1	2.3	-1.6	2.0	-0.8	1.0
Body weight	5.2	22.5	35.0	5.9	-5.3	5.4	-3.3	2.9
Weight adjusted by age	0.1	0.2	0.6	0.4	-0.8	0.3	0.4	0.2
Bone surface	0.1	0.2	0.9	0.1	0.5	-0.1	0.9	0.0
Bone volume	0.3	0.6	2.1	-0.3	0.7	-0.5	1.5	0.0
Breakpoint value in progressive ratio session	0.6	0.7	2.3	1.5	-0.5	0.0	-0.2	-1.0
Number of licking bursts	0.3	0.5	1.2	-0.8	0.3	-0.2	1.1	0.6
Context. condit. distance diff. score	1.4	1.7	4.4	0.9	-1.3	1.3	-2.1	0.1
Locomotion velocity, session 1	0.6	0.7	1.6	0.9	-0.5	0.7	-0.2	1.3
Locomotion distance, session 1	1.9	2.4	5.2	2.3	-1.3	1.6	-0.7	1.4
Locomotion velocity, session 2	0.2	0.2	0.7	0.8	-0.2	0.4	-0.5	-0.1
Locomotion distance, session 2	0.2	0.3	1.2	1.1	-0.0	0.3	0.5	0.1
Locomotion velocity, session 3	0.5	0.6	2.3	0.5	0.2	-0.0	-0.4	-1.5
Locomotion distance, session 3	0.3	0.3	0.8	0.9	-0.5	0.5	-0.4	-0.2
Stereotopy head waving bouts, day 3	2.2	2.6	3.8	-1.9	1.9	-1.6	0.9	-1.5
Stereotopy head waving duration, day 3	0.2	0.2	0.6	-0.8	0.6	-0.3	0.2	-0.3
Locomotion velocity, session 7	0.9	1.0	1.8	0.8	-1.1	1.2	-0.3	1.3
Locomotion distance, session 7	0.6	0.7	2.5	0.4	-0.7	0.7	-0.2	1.6
Stereotopy head waving bouts, day 7	0.8	1.0	1.6	-1.3	0.9	-0.7	0.8	-1.0
Stereotopy head waving duration, day 7	0.5	0.6	1.9	-0.7	0.5	-0.5	0.4	-1.4
Locomotion velocity, session 8	6.7	8.0	9.5	3.0	-3.0	3.1	-2.8	2.1
Locomotion distance, session 8	1.1	1.7	2.8	1.7	-1.4	1.4	-1.1	0.6
Degree of sensitization distance	1.1	1.1	3.1	0.4	-1.0	1.0	-0.8	1.8
Degree of sensitization stereotypy	0.9	1.0	2.3	-1.5	0.9	-0.7	1.0	-0.7
Conditioned locomotion	0.3	0.3	0.8	-0.4	0.4	-0.5	0.0	-0.9
Cocaine response after cond. corrected	1.2	1.5	3.0	-1.7	1.1	-0.6	1.6	0.5
Cocaine response after cond. not corrected	1.6	1.9	4.0	-2.0	1.1	-0.7	1.7	1.0
Cocaine response before conditioning	0.1	0.1	0.4	-0.6	0.1	-0.2	-0.0	0.5
Saline control response	0.5	0.7	1.8	-0.0	-0.7	1.0	-0.3	1.3
Bone: connectivity density	3.3	5.2	6.7	-2.1	2.6	-2.4	2.1	-2.1
Bone: cortical apparent density	4.2	5.8	8.2	-2.7	2.8	-2.9	1.4	-2.0
Bone: cortical area	0.1	0.1	0.3	-0.6	0.3	-0.2	0.4	-0.1
Bone: cortical porosity	0.6	0.7	1.4	-1.2	0.5	-0.5	1.1	0.4
Bone: cortical porosity	0.6	0.7	1.3	-1.2	0.3	-0.2	1.0	1.0
Bone: cortical thickness	1.0	1.6	3.2	-1.8	1.2	-1.2	0.6	-1.3
Bone: cortical thickness	4.1	4.8	6.0	-2.4	2.4	-2.4	1.5	-2.2
Bone: cortical tissue density	4.3	5.8	8.3	-2.7	2.8	-2.9	1.4	-1.9
Condit. Reinf. active minus inactive responses	1.0	1.1	1.9	-0.8	1.2	-1.2	0.4	-1.4
Condit. Reinf. active-inactive response ratio	1.4	1.5	3.2	-1.0	1.2	-1.3	0.2	-1.8
Condit. Reinf. active responses	0.8	1.0	1.4	-1.0	1.2	-1.2	0.6	-0.9
Condit. Reinf. inactive responses	0.3	0.3	0.7	-0.8	0.3	-0.3	0.6	0.6
Incentive salience index mean	1.7	2.0	3.2	-1.4	1.8	-1.6	1.1	-1.1
Condit. Reinf. lever presses	1.2	1.7	2.5	-1.4	1.6	-1.3	1.5	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.9	1.7	-0.8	0.9	-1.2	1.3	-0.4
Condit. Reinf. active-inactive response ratio	0.8	1.0	1.8	-0.8	1.0	-1.1	1.4	-0.4
Condit. Reinf. active responses	1.2	1.6	3.1	-1.0	1.3	-1.5	1.8	-0.5
Condit. Reinf. inactive responses	1.2	1.5	2.6	-1.1	1.4	-1.3	1.6	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.2	0.3	-0.3	0.0	-0.5
Condit. Reinf. lever reinforcers received	1.2	1.7	2.6	-0.9	1.4	-1.5	1.6	-0.8
Conditioned reinforcement - actives	0.2	0.4	1.4	-0.7	-0.1	-0.1	0.2	1.2
Conditioned reinforcement - inactives	0.1	0.1	0.5	-0.1	0.5	-0.7	0.1	-0.1
Conditioned locomotion	0.7	1.0	2.1	-1.5	0.7	-0.7	1.1	0.7
Patch foraging indifference point 0 sec	1.2	2.2	3.3	-1.4	1.8	-1.7	1.0	-1.3
Patch foraging indifference point AUC	0.0	0.0	0.0	-0.0	0.1	0.1	0.1	0.0
Delay disc. indifference point, 0s delay	1.7	1.8	2.2	-1.5	1.5	-1.3	1.2	-1.3
Delay disc. indifference point, 16s delay	0.3	0.4	0.8	-0.9	0.6	-0.5	-0.5	-0.5
Delay disc. indifference point, 2s delay	1.4	1.6	3.1	-1.8	1.2	-0.9	1.5	0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.3	-0.3	0.3	-0.6	0.7
Delay disc. indifference point, 4s delay	0.8	0.9	1.5	-1.2	0.9	-0.9	0.9	-0.6
Delay disc. indifference point, 8s delay	0.2	0.2	0.8	-0.9	0.3	-0.3	0.3	0.0
Indifference point function ln k	0.1	0.2	0.6	-0.1	-0.1	0.1	-0.7	-0.6
Indifference point function log k	0.1	0.2	0.6	-0.1	-0.1	0.1	-0.7	-0.6
Patch foraging total patch changes 0 sec	0.8	1.4	2.3	-1.1	1.5	-1.4	0.8	-1.0
Patch foraging total patch changes 12 sec	4.2	5.4	6.8	-2.5	2.4	-2.6	2.5	-1.4
Patch foraging total patch changes 18 sec	0.2	0.3	0.4	-0.4	0.6	-0.6	0.5	-0.5
Patch foraging total patch changes 24 sec	0.8	1.3	2.8	-1.7	1.0	-1.1	1.0	-0.8
Patch foraging total patch changes 6 sec	1.3	2.0	3.6	-1.2	1.9	-1.6	1.2	-1.1
Patch foraging time to switch 0 sec	0.1	0.1	0.2	-0.1	0.3	-0.4	0.5	-0.2
Patch foraging water rate 0 sec	0.1	0.1	0.4	-0.1	0.4	-0.4	0.0	-0.7
Patch foraging water rate 12 sec	0.1	0.3	0.6	0.7	-0.8	0.1	-0.5	-0.3
Patch foraging water rate 18 sec	0.5	0.7	0.9	-0.8	0.7	-0.9	1.0	-0.9
Patch foraging water rate 24 sec	0.4	0.6	1.0	-0.4	1.0	-0.9	0.6	-0.7
Patch foraging water rate 6 sec	1.3	2.0	2.7	-0.9	1.5	-1.6	1.2	-1.6
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.9	0.5	0.0	-0.1	-0.9	-0.3
Distance traveled before self-admin	0.1	0.2	0.5	0.7	0.0	-0.3	0.5	0.1
Distance traveled after self-admin	0.4	0.6	1.5	1.2	-0.6	0.8	-0.6	0.2
Extensor digitorum longus weight	8.4	32.9	41.2	5.8	-6.4	6.4	-5.4	4.5
Bone: elastic displacement	0.0	0.0	0.2	-0.2	0.1	0.1	0.0	0.4
Bone: elastic work	0.1	0.1	0.3	-0.1	0.4	-0.2	0.5	-0.4
Bone: endosteal estimation	1.8	4.0	5.7	2.4	-2.1	2.2	-0.7	2.2
Bone: endosteal perimeter	1.3	2.8	5.1	2.2	-1.7	1.7	-0.8	1.4
Epididymis fat weight	0.1	0.4	0.7	0.7	-0.8	0.6	-0.0	0.8
Delta time in closed arm before/after self-admin	3.1	2.9	4.3	1.9	-1.8	2.1	-1.7	0.7
Delta time in open arm before/after self-admin	0.0	0.0	0.1	0.1	-0.2	0.0	-0.3	0.2
Diff in mean of infusions in LGA sessions	0.3	0.3	1.1	0.7	-0.2	-0.1	0.1	-1.0
Delay discount exponential model param	0.3	0.3	1.0	1.0	-0.5	0.3	-0.2	0.1
Extinction: sum of active levers before priming	1.0	1.1	1.8	0.8	-1.3	1.3	-0.8	0.7
Active lever presses in extinction session 6	0.8	0.8	2.4	-0.1	0.7	-0.4	1.5	-0.9
Bone: final force	0.7	1.1	2.5	-1.2	0.9	-0.7	1.6	-0.0
Bone: final moment	0.5	0.8	2.1	-1.1	0.8	-0.5	1.4	0.1
Food consumed during 24 hour testing period	0.7	0.9	1.3	1.0	-1.1	1.1	-0.7	0.9
Glucose	0.4	0.6	1.3	-1.0	0.3	0.4	0.6	1.2
Heart weight	2.9	4.4	6.0	2.2	-2.2	2.5	-1.8	1.8
Delay discount hyperbolic model param	0.2	0.3	1.0	1.0	-0.5	0.3	-0.2	-0.0
Intermittent access intake day 1-15 change	0.3	0.6	2.3	0.7	0.1	-0.3	-0.1	-1.5
Intermittent access intake escalation	0.2	0.5	1.9	0.7	0.1	-0.2	-0.1	-1.4
Intermittent access intake escalation 2	0.3	0.3	1.0	1.0	-0.5	0.4	-0.4	-0.5
Intermitt. access day 1 inactive lever presses	0.7	2.7	6.7	-0.5	1.8	-1.7	0.8	-2.6
Intermitt. access day 15 inactive lever presses	1.0	2.1	3.6	-1.2	1.7	-1.6	0.6	-1.9
Intermitt. access escalation Index	1.2	1.7	3.5	1.0	-1.9	1.5	-1.2	0.3
Intermittent access day 1 total infusions	0.1	0.1	0.4	0.0	-0.1	-0.2	-0.1	0.7
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.7	-0.1	-0.1	-0.5	-0.6
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.5	0.3	0.3	-0.5	-0.2	-0.7
Intermittent access total infusions	0.1	0.1	0.3	0.5	-0.1	-0.2	-0.5	-0.1
Intermittent access day 1 locomotion	0.2	0.2	0.9	-0.4	0.2	-0.1	0.1	1.0
Intermittent access day 15 total locomotion	0.3	0.6	0.8	-0.9	0.7	-0.5	0.9	0.8
Intermittent access total locomotion	0.6	0.8	1.4	-1.2	1.0	-0.9	0.7	0.2
Intermittent access standard deviation	1.0	2.0	4.5	-0.0	1.4	-1.8	0.7	-2.1
Left kidney weight	0.6	2.6	5.7	2.4	-1.4	1.2	-1.5	-1.1
Right kidney weight	0.1	0.4	1.0	0.9	-0.1	-0.1	0.4	-1.0
Cocaine induced anxiety	2.1	3.0	5.5	2.3	-1.9	1.9	-1.5	0.0
Post-drug Anxiety	0.8	0.9	1.5	1.2	-1.0	0.8	-1.0	-0.4
Baseline Anxiety	1.6	1.9	4.7	-2.2	1.2	-1.3	1.2	0.4
Tail length	0.6	2.3	6.0	2.4	-1.4	1.3	-1.4	0.1
Length with tail	2.3	10.2	22.6	4.8	-3.5	3.1	-2.5	1.0
Length without tail	2.4	7.8	11.1	3.3	-3.3	3.1	-2.0	2.0
Times rat made contact with spout	0.9	1.0	1.5	-1.2	1.0	-0.9	1.2	0.1
Lifetime Intake	0.1	0.1	0.2	0.4	0.1	-0.5	-0.4	-0.4
Liver weight, left	0.2	0.4	1.1	0.5	-0.5	0.6	0.1	1.1
Liver weight, right	0.4	0.7	1.4	-0.7	1.1	-0.7	0.3	-1.2
Locomotor activity	0.6	1.0	2.2	-1.1	0.7	-0.9	1.5	0.2
Locomotor testing distance	1.7	3.1	4.8	-2.2	1.7	-1.9	1.8	-0.9
Locomotor testing rearing	4.0	8.1	11.1	-2.9	3.3	-3.2	2.0	-2.7
Locomotion in novel chamber	3.8	4.9	7.3	-2.7	2.6	-2.3	2.3	-0.5
Locomotion in novel chamber post-restriction	0.3	0.5	1.6	-0.5	0.8	-0.5	1.3	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.4	1.7	0.2	-0.2	0.6	-0.1	1.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.6	0.1	-0.2	0.2	0.0
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	-0.9	0.3	-0.3	-0.1	-0.4
Bouts of movement, locomotor time 1	0.3	0.4	0.9	1.0	-0.7	0.4	-0.4	-0.2
Total resting periods, locomotor time 1	0.6	0.7	1.1	1.1	-1.0	0.7	-0.5	0.7
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	0.2	-0.1	0.4	0.3
Distance moved, locomotor task time 1	0.0	0.0	0.1	-0.3	0.0	0.2	-0.2	0.1
Vertical activity count, locomotor time 1	0.2	0.5	1.6	0.2	-0.7	0.7	-0.4	1.3
Time >=10cm from walls, locomotor time 2	0.7	1.0	2.3	-1.5	0.5	-1.0	1.2	0.4
Bouts of movement, locomotor time 2	0.5	0.7	2.7	-0.1	0.5	-0.9	0.0	-1.6
Total resting periods, locomotor time 2	0.4	0.7	2.9	0.2	0.3	-0.7	-0.2	-1.7
Rest time, locomotor task time 2	0.5	0.7	1.5	1.2	-0.8	0.8	-0.6	0.4
Distance moved, locomotor task time 2	0.2	0.2	0.6	-0.0	-0.1	0.7	-0.1	0.7
Vertical activity count, locomotor time 2	0.5	0.6	1.6	0.2	-0.6	0.9	-0.6	1.3
Light reinforcement 1	1.8	4.3	5.7	-1.5	2.3	-2.4	1.8	-2.2
Light reinforcement 2	0.6	0.9	1.7	-0.9	1.3	-0.8	1.3	-0.1
Bone: marrow area	1.7	3.8	5.5	2.4	-2.0	2.2	-0.7	2.1
Bone: maximum diameter	0.0	0.1	0.3	0.1	-0.0	-0.2	0.5	0.0
Bone: maximum force	0.0	0.1	0.2	0.1	-0.2	0.4	0.4	0.3
Bone: maximum moment	0.1	0.1	0.3	0.2	-0.3	0.6	0.2	0.4
Mean time between licks in bursts	0.7	1.8	2.6	1.6	-1.4	1.6	-0.9	1.2
Mean num. licks in bursts	0.1	0.2	0.4	-0.2	0.5	-0.4	-0.2	-0.6
Cd content in liver	1.4	1.5	2.7	1.6	-1.2	1.4	-1.0	0.9
Co content in liver	1.8	2.1	3.3	1.8	-1.5	1.3	-1.7	0.6
Cu content in liver	0.6	0.8	2.3	1.0	0.2	-0.3	-0.6	-1.5
Fe content in liver	1.5	1.8	2.3	1.5	-1.3	1.5	-0.7	1.5
K content in liver	1.2	1.1	3.6	-0.2	0.8	-1.1	0.3	-1.9
Mg content in liver	1.2	1.3	4.4	-0.4	0.7	-1.0	-0.5	-2.1
Mn content in liver	1.2	1.3	3.3	-0.2	1.1	-1.4	0.1	-1.8
Na content in liver	0.4	0.4	1.3	-0.5	0.4	-0.5	1.2	-0.1
Rb content in liver	1.3	1.5	2.8	-1.3	1.7	-1.3	0.9	-0.7
Se content in liver	5.9	7.0	10.2	-2.0	2.9	-3.2	1.9	-3.0
Sr content in liver	0.8	0.7	1.3	1.1	-0.5	0.0	-1.1	-0.9
Zn content in liver	3.0	3.4	5.3	-1.2	2.1	-2.0	1.2	-2.3
Bone: minimum diameter	0.5	0.9	1.4	1.1	-0.9	1.2	-0.4	0.9
Time in familiar zone, hab. session 1	0.9	0.8	2.0	-0.7	0.4	0.1	1.2	1.4
Time in novel zone, hab. session 1	0.9	0.9	2.7	-0.7	0.8	-0.8	-0.4	-1.6
Total zone transitions, hab. session 1	1.8	2.5	3.1	1.8	-1.6	1.7	-1.4	1.3
Total locomotion distance, hab. session 1	0.0	0.1	0.2	0.1	-0.2	0.1	-0.5	-0.1
Locomotion velocity, hab. session 1	0.3	0.5	0.8	0.9	-0.9	0.5	-0.8	0.0
Time in familiar zone, hab. session 2	0.4	0.5	0.9	-0.5	0.7	-0.8	0.9	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.4	0.4	-0.3	-0.0	-0.7
Total zone transitions, hab. session 2	1.0	1.3	2.7	0.9	-0.9	1.3	-0.6	1.7
Total locomotion distance, hab. session 2	0.3	0.4	1.1	0.4	-0.5	0.5	-0.0	1.1
Locomotion velocity, hab. session 2	0.5	0.6	1.5	0.7	-0.8	0.8	-0.3	1.2
Novel to familiar place preference ratio	1.2	1.3	2.1	1.3	-1.4	0.9	-1.5	-0.4
Novelty place preference	1.1	1.2	2.3	1.0	-1.4	0.8	-1.5	-0.3
Time in novel zone, NPP test	0.6	0.6	1.3	0.5	-1.0	0.5	-1.1	-0.5
Total zone transitions, NPP test	1.0	1.4	5.4	0.7	-0.6	0.9	0.3	2.3
Total locomotion distance, NPP test	0.3	0.4	1.6	0.0	0.1	0.2	0.6	1.2
Locomotion velocity, NPP test	0.5	0.7	2.2	0.7	-0.4	0.7	-0.0	1.5
Intraocular pressure	2.8	4.1	6.8	1.6	-2.0	2.2	-1.6	2.6
Delta distance traveled before/after self-admin	0.9	1.0	1.6	0.8	-1.0	1.2	-1.3	0.4
Delta ambulatory time before/after self-admin	0.7	0.9	1.9	0.5	-1.0	1.4	-1.0	0.6
Parametrial fat weight	0.4	1.0	2.5	-0.6	0.9	-1.0	1.6	-0.5
Pavlov. Cond. lever latency	2.5	3.2	5.5	2.1	-2.0	1.5	-2.3	-0.0
Pavlov. Cond. magazine entry latency	8.8	11.3	14.8	-3.9	3.7	-3.5	3.6	-1.6
Pavlov. Cond. change in total contacts	8.1	8.6	11.6	-3.4	3.4	-3.1	2.2	-2.3
Pavlov. Cond. index score	7.9	10.0	14.2	-3.8	3.5	-3.1	3.5	-1.0
Pavlov. Cond. latency score	6.2	7.9	11.6	-3.4	3.1	-2.7	3.3	-0.7
Pavlov. Cond. lever contacts	3.2	3.8	6.5	-2.3	2.1	-1.7	2.6	0.1
Pavlov. Cond. magazine entry number	11.5	14.4	21.3	4.6	-4.3	3.9	-3.7	2.0
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.1	1.3	-1.2	1.2	-1.4	0.6
Pavlov. Cond. lever-magazine prob. diff.	9.2	11.4	15.7	-4.0	3.8	-3.4	3.7	-1.2
Pavlov. Cond. response bias	9.2	11.4	16.0	-4.0	3.8	-3.5	3.4	-1.7
Pavlov. Cond. lever latency	0.4	0.5	0.8	0.9	-0.6	0.7	-0.9	0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	1.2	-0.1	-0.4	0.3	0.1	1.1
Pavlov. Cond. change in total contacts	0.3	0.5	0.9	-0.9	0.9	-0.8	0.6	0.0
Pavlov. Cond. index score	0.2	0.3	0.4	-0.7	0.4	-0.3	0.6	0.6
Pavlov. Cond. latency score	0.2	0.3	0.7	-0.6	0.2	-0.2	0.6	0.8
Pavlov. Cond. lever contacts	0.5	0.6	1.1	-1.0	0.8	-0.7	1.0	0.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.6	-0.3	0.1	-0.4	-0.6
Pavlov. Cond. intertrial magazine entries	1.5	2.3	3.8	1.7	-1.7	1.2	-2.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.5	0.2	-0.1	0.5	0.7
Pavlov. Cond. response bias	0.8	1.1	1.7	-1.2	1.1	-1.0	1.3	-0.1
Time in closed arm before self-admin	1.5	1.9	3.5	-1.2	1.9	-1.5	0.6	-1.4
Time in closed arm after self-admin	0.5	0.6	1.4	0.6	-0.1	0.2	-1.2	-1.0
Time in open arm before self-admin	1.3	1.4	2.6	1.3	-1.6	1.2	-0.6	0.9
Time in open arm after self-admin	0.3	0.3	0.6	0.7	-0.8	0.5	-0.3	0.6
Bone: periosteal estimation	0.3	0.6	0.9	0.8	-0.7	0.9	0.1	1.0
Bone: periosteal perimeter	0.7	1.2	1.8	1.2	-1.1	1.2	-0.1	1.4
Bone: post-yield work	1.0	1.4	2.2	1.2	-1.3	1.5	-1.1	0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.5	0.1	-0.2	-0.0	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.4	-0.0	-0.1	-0.1	0.4
Progressive ratio test 1 inactive lever presses	0.2	0.4	1.0	0.1	0.5	-0.7	-0.1	-1.0
Progressive ratio test 2 active lever presses	0.5	0.6	1.3	-0.7	0.8	-1.1	0.8	0.2
Progressive ratio test 2 breakpoint	0.6	0.7	1.4	-0.8	0.8	-1.2	0.8	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.4	0.2	0.4	-0.6	0.2	0.0
Incentive Sensitization - Responses	1.0	1.4	2.5	-1.0	1.2	-1.6	1.5	0.4
Incentive Sensitization - Breakpoint	1.0	1.3	2.2	-0.9	1.1	-1.5	1.4	0.4
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.5	0.3	-0.2	0.4	-0.1
Progressive ratio	0.1	0.1	0.3	0.2	0.3	-0.3	0.5	0.2
Food seeking constrained by brief footshock	0.4	0.5	0.8	-0.6	0.7	-0.8	0.9	-0.6
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.6	-0.1	0.1	-0.3	-0.3
Retroperitoneal fat weight	0.1	0.2	0.4	-0.4	0.6	-0.5	0.5	-0.4
Reaction time number correct	0.7	1.3	1.9	1.1	-1.3	1.2	-0.6	1.4
Reaction time mean minus median	0.1	0.3	0.6	0.2	-0.7	0.6	-0.5	0.6
Reaction time mean minus median AUC	0.1	0.2	0.5	-0.7	-0.2	0.1	-0.0	0.5
Reaction time num false alarms	0.8	1.1	2.1	-1.1	0.8	-0.9	1.4	0.9
Reaction time num false alarms AUC	0.6	0.9	2.0	-0.9	0.6	-0.8	1.4	0.9
Reaction time trials correct on left	0.7	1.3	1.9	1.1	-1.3	1.2	-0.6	1.4
Reaction time trials on left	0.7	1.3	1.9	1.1	-1.3	1.2	-0.5	1.4
Reaction time mean	0.3	0.5	1.8	-0.2	0.2	-0.8	-0.2	-1.3
Reaction time mean AUC	0.4	0.7	2.4	-0.2	0.3	-0.8	-0.2	-1.6
Median of all reaction times	1.0	1.4	3.7	-0.6	0.8	-1.5	0.2	-1.9
Reaction time omissions	0.4	0.7	1.1	-0.5	0.8	-1.1	0.5	-1.0
Reaction time false alarm rate	1.1	1.5	2.3	-1.5	1.2	-1.3	1.5	0.1
Reaction time premature initiation rate	0.5	0.7	2.3	-0.3	0.3	-0.8	0.5	-1.5
Reaction time premature initiations	0.1	0.2	0.5	0.6	-0.7	0.2	-0.1	-0.6
Std. dev. reaction times	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.1	-0.2
Reaction time trials completed	0.7	1.3	1.9	1.1	-1.3	1.2	-0.5	1.4
Reaction time trials AUC	0.6	1.2	2.0	1.0	-1.3	1.2	-0.6	1.4
Run reversals in cocaine runway, females	2.2	2.1	4.7	1.2	-1.6	1.4	-2.2	0.1
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.7	0.4	-0.3	0.4	0.3
Latency to leave start box in cocaine runway	1.3	1.5	2.3	1.5	-1.1	1.3	-1.3	0.9
Latency to leave start box in cocaine runway, F	2.1	2.4	2.9	1.7	-1.7	1.6	-1.4	1.3
Latency to leave start box in cocaine runway, M	0.3	0.3	0.6	0.2	0.8	-0.3	-0.1	-0.8
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.5	-0.3	0.2	0.2	-0.1
Total sessions with >9 infusions	0.2	0.2	0.4	0.1	0.3	-0.5	-0.6	-0.6
Short access day 1 total inactive lever presses	1.4	1.8	3.4	-0.9	1.9	-1.7	0.9	-1.1
Short access day 10 total inactive lever presses	0.2	0.4	1.3	0.9	0.1	-0.3	-0.2	-1.1
Short access day 1 total infusions	0.3	0.4	0.9	-0.1	0.8	-0.6	-0.5	-1.0
Short access day 10 total infusions	0.2	0.2	0.6	-0.4	0.6	-0.7	0.2	-0.2
Short access total infusions	0.2	0.2	0.5	0.1	0.5	-0.7	-0.2	-0.7
Short access day 1 locomotion	0.9	1.1	2.1	-0.8	1.4	-1.1	0.4	-1.2
Short access day 10 total locomotion	1.2	2.3	3.6	-1.9	1.7	-1.5	1.6	0.2
Short access total locomotion	0.2	0.3	0.7	-0.4	0.8	-0.6	0.3	0.1
One hour access (0.3 mA shock)	0.4	0.5	0.8	0.3	-0.8	0.5	-0.6	0.9
Compulsive drug intake	0.5	0.5	2.1	-0.2	-0.5	0.5	-1.5	-0.2
One hour access (shock baseline)	0.0	0.1	0.3	0.6	-0.1	-0.1	0.0	-0.0
Social response proportion	0.2	0.3	0.6	-0.0	-0.2	0.8	-0.5	0.7
Social responses	0.2	0.2	0.6	-0.2	0.8	0.1	0.7	0.4
Social time	0.3	0.3	0.9	0.1	-0.1	0.3	0.9	0.9
Soleus weight	0.4	1.2	3.2	-1.1	0.1	0.4	1.2	1.8
Bone: stiffness	0.0	0.0	0.0	0.2	-0.2	0.2	0.2	-0.0
Tibialis anterior weight	1.2	4.2	6.3	1.9	-2.3	2.5	-1.5	1.8
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.3	0.4	-0.0	0.6	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.7	-0.3	-0.1	-0.2	0.8	0.5
Time to tail flick, test, before self-admin	0.7	0.8	1.7	0.7	-1.3	1.0	-0.6	0.6
Time to tail flick, test, after self-admin	0.3	0.4	0.9	-0.4	0.7	-0.1	1.0	0.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.8	-0.7	0.2	-0.5	1.3	0.3
Delta time to tail flick, test, before/after SA	2.1	2.2	4.0	-1.5	2.0	-1.5	1.6	-0.1
Tibia length	1.2	3.3	5.8	1.3	-2.0	2.4	-0.9	2.1
Ambulatory time before self-admin	0.1	0.2	1.0	1.0	-0.1	-0.2	0.0	-0.2
Ambulatory time after self-admin	1.3	1.5	3.3	1.8	-1.1	1.4	-0.9	0.5
Bone: tissue strength	1.1	1.1	1.7	0.6	-1.2	1.3	-1.1	0.8
Total heroin consumption	2.3	2.7	5.7	-0.9	1.5	-1.8	2.4	-1.0
Bone: trabecular number	5.2	8.5	10.5	-3.0	3.2	-3.1	3.2	-1.9
Bone: trabecular spacing	1.9	2.5	5.1	1.1	-1.7	1.7	-0.6	2.2
Bone: trabecular thickness	0.1	0.2	0.3	-0.1	0.4	-0.3	0.5	-0.5
Bone: trabecular tissue density	0.3	0.5	1.6	0.1	-0.3	0.1	-1.3	-0.8
Water consumed over 24 hours	0.2	0.2	0.8	0.1	-0.5	0.4	0.0	0.9
Number of responses in last shaping day	0.5	0.6	1.5	0.1	0.7	-0.7	-0.5	-1.2