Hub : Genes

Casc3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Casc3 0.1 0.06 3.3e-12 0.1 0.09 0.1 0.11 1.2e-11 3.3e-10 1.0e-11 1.5e-12
2 RMTg mRNA stability Casc3 0.43 0.19 6.1e-07 0.13 0.24 0.23 0.22 2.2e-04 4.9e-07 8.4e-07 1.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.33.84.1-2.01.9
Area under the delay curve0.10.10.1-0.30.2
BMI with tail2.58.09.13.0-2.6
BMI without tail0.10.20.20.5-0.5
Body weight5.121.423.94.9-4.4
Weight adjusted by age0.20.30.30.5-0.5
Bone surface0.00.00.10.00.3
Bone volume0.20.30.4-0.30.7
Breakpoint value in progressive ratio session0.10.10.1-0.20.4
Number of licking bursts0.20.20.4-0.20.7
Context. condit. distance diff. score1.92.32.91.3-1.7
Locomotion velocity, session 10.30.30.40.6-0.5
Locomotion distance, session 11.82.33.11.8-1.2
Locomotion velocity, session 20.10.10.10.2-0.4
Locomotion distance, session 20.00.10.10.30.1
Locomotion velocity, session 30.10.10.1-0.30.2
Locomotion distance, session 30.10.10.20.4-0.3
Stereotopy head waving bouts, day 32.02.43.0-1.71.3
Stereotopy head waving duration, day 30.00.00.1-0.30.0
Locomotion velocity, session 71.11.21.81.4-0.8
Locomotion distance, session 70.40.50.80.9-0.4
Stereotopy head waving bouts, day 70.30.40.5-0.70.5
Stereotopy head waving duration, day 70.20.20.3-0.60.3
Locomotion velocity, session 88.510.210.53.1-3.2
Locomotion distance, session 81.31.92.11.5-1.3
Degree of sensitization distance1.31.31.51.2-1.0
Degree of sensitization stereotypy0.60.70.8-0.90.7
Conditioned locomotion0.10.10.2-0.50.3
Cocaine response after cond. corrected0.40.50.5-0.60.7
Cocaine response after cond. not corrected0.50.60.7-0.70.8
Cocaine response before conditioning0.00.10.1-0.20.3
Saline control response0.30.40.70.8-0.5
Bone: connectivity density3.45.46.0-2.42.2
Bone: cortical apparent density5.97.88.4-2.92.7
Bone: cortical area0.00.10.1-0.10.3
Bone: cortical porosity0.00.00.1-0.10.3
Bone: cortical porosity0.00.00.00.10.1
Bone: cortical thickness0.71.21.3-1.21.0
Bone: cortical thickness5.05.76.9-2.62.2
Bone: cortical tissue density6.07.98.5-2.92.7
Condit. Reinf. active minus inactive responses0.91.01.3-1.10.8
Condit. Reinf. active-inactive response ratio1.11.21.6-1.30.9
Condit. Reinf. active responses0.81.01.3-1.10.8
Condit. Reinf. inactive responses0.10.10.1-0.30.2
Incentive salience index mean2.12.62.7-1.61.6
Condit. Reinf. lever presses1.11.51.9-1.11.4
Condit. Reinf. active minus inactive responses1.61.92.3-1.31.5
Condit. Reinf. active-inactive response ratio1.41.51.8-1.11.3
Condit. Reinf. active responses2.33.33.8-1.62.0
Condit. Reinf. inactive responses2.02.52.7-1.51.7
Condit. Reinf. lever presses0.20.20.2-0.40.5
Condit. Reinf. lever reinforcers received2.43.33.9-1.72.0
Conditioned reinforcement - actives0.70.71.0-0.61.0
Conditioned reinforcement - inactives2.73.03.2-1.81.7
Conditioned locomotion0.60.81.3-0.51.1
Patch foraging indifference point 0 sec2.43.83.9-1.92.0
Patch foraging indifference point AUC0.00.00.10.2-0.3
Delay disc. indifference point, 0s delay0.91.01.3-0.91.1
Delay disc. indifference point, 16s delay0.20.20.3-0.5-0.2
Delay disc. indifference point, 2s delay0.90.91.5-0.71.2
Delay disc. indifference point, 24s delay0.10.10.10.1-0.3
Delay disc. indifference point, 4s delay0.40.40.5-0.70.6
Delay disc. indifference point, 8s delay0.10.10.1-0.20.3
Indifference point function ln k0.00.00.00.0-0.1
Indifference point function log k0.00.00.00.0-0.1
Patch foraging total patch changes 0 sec1.82.93.0-1.71.7
Patch foraging total patch changes 12 sec6.78.79.8-2.73.1
Patch foraging total patch changes 18 sec0.70.91.0-0.91.0
Patch foraging total patch changes 24 sec1.41.71.8-1.31.3
Patch foraging total patch changes 6 sec2.53.83.8-1.92.0
Patch foraging time to switch 0 sec0.10.20.2-0.40.5
Patch foraging water rate 0 sec0.10.10.1-0.40.3
Patch foraging water rate 12 sec0.00.00.00.1-0.2
Patch foraging water rate 18 sec0.60.81.0-0.81.0
Patch foraging water rate 24 sec0.81.21.4-1.01.2
Patch foraging water rate 6 sec1.92.72.8-1.61.7
Seeking ratio, delayed vs. immediate footshock0.10.20.3-0.50.1
Distance traveled before self-admin0.00.00.00.1-0.1
Distance traveled after self-admin1.41.61.81.1-1.3
Extensor digitorum longus weight9.637.638.76.2-6.0
Bone: elastic displacement0.00.00.00.00.2
Bone: elastic work0.10.10.1-0.20.3
Bone: endosteal estimation1.94.05.12.3-1.7
Bone: endosteal perimeter1.02.02.71.6-1.2
Epididymis fat weight0.00.00.10.30.2
Delta time in closed arm before/after self-admin4.34.14.32.0-2.1
Delta time in open arm before/after self-admin0.00.00.1-0.0-0.3
Diff in mean of infusions in LGA sessions0.00.00.00.00.1
Delay discount exponential model param0.00.00.00.1-0.0
Extinction: sum of active levers before priming1.71.71.71.3-1.3
Active lever presses in extinction session 61.31.31.7-0.91.3
Bone: final force0.40.60.9-0.60.9
Bone: final moment0.20.40.6-0.40.8
Food consumed during 24 hour testing period0.70.91.21.1-0.8
Glucose0.00.00.00.10.2
Heart weight3.75.36.22.5-2.1
Delay discount hyperbolic model param0.00.00.00.2-0.2
Intermittent access intake day 1-15 change0.40.40.5-0.70.6
Intermittent access intake escalation0.40.40.5-0.70.6
Intermittent access intake escalation 20.00.00.0-0.10.1
Intermitt. access day 1 inactive lever presses2.32.52.9-1.71.5
Intermitt. access day 15 inactive lever presses4.95.45.7-2.42.2
Intermitt. access escalation Index2.72.42.81.4-1.7
Intermittent access day 1 total infusions0.20.30.3-0.50.5
Intermittent access day 15 total infusions0.50.60.8-0.90.6
Intermittent access terminal intake (last 3 days)0.80.81.0-1.00.8
Intermittent access total infusions0.20.20.4-0.60.3
Intermittent access day 1 locomotion0.30.40.5-0.50.7
Intermittent access day 15 total locomotion0.60.61.0-0.51.0
Intermittent access total locomotion0.91.11.2-0.91.1
Intermittent access standard deviation2.72.83.5-1.91.5
Left kidney weight1.13.13.91.5-2.0
Right kidney weight0.20.50.70.5-0.8
Cocaine induced anxiety2.12.42.51.6-1.6
Post-drug Anxiety0.40.50.60.6-0.8
Baseline Anxiety1.11.11.3-1.11.0
Tail length0.10.40.50.5-0.7
Length with tail2.48.89.03.0-2.9
Length without tail3.37.38.22.9-2.5
Times rat made contact with spout0.91.11.4-0.91.2
Lifetime Intake0.30.30.5-0.70.4
Liver weight, left0.00.00.1-0.10.3
Liver weight, right0.40.70.9-1.00.6
Locomotor activity0.61.01.4-0.81.2
Locomotor testing distance2.33.84.0-1.92.0
Locomotor testing rearing6.610.311.3-3.43.0
Locomotion in novel chamber4.35.35.4-2.32.3
Locomotion in novel chamber post-restriction1.11.42.1-0.81.4
Fecal boli incidents, locomotor time 10.20.30.40.6-0.4
Change in fecal boli incidents, locomotor task0.00.00.10.2-0.1
Time >=10cm from walls, locomotor time 10.10.10.1-0.30.3
Bouts of movement, locomotor time 10.40.50.70.4-0.9
Total resting periods, locomotor time 10.91.01.30.8-1.1
Rest time, locomotor task time 10.10.10.2-0.20.4
Distance moved, locomotor task time 10.00.00.00.1-0.2
Vertical activity count, locomotor time 10.30.30.40.7-0.4
Time >=10cm from walls, locomotor time 21.11.11.5-0.91.2
Bouts of movement, locomotor time 20.40.40.7-0.80.3
Total resting periods, locomotor time 20.20.20.5-0.70.1
Rest time, locomotor task time 20.60.70.70.8-0.8
Distance moved, locomotor task time 20.30.30.50.7-0.4
Vertical activity count, locomotor time 20.50.60.80.9-0.6
Light reinforcement 13.76.87.0-2.72.6
Light reinforcement 20.60.81.0-0.81.0
Bone: marrow area1.73.74.72.2-1.7
Bone: maximum diameter0.00.10.1-0.10.3
Bone: maximum force0.00.10.20.4-0.0
Bone: maximum moment0.10.20.30.6-0.2
Mean time between licks in bursts0.71.01.41.2-0.7
Mean num. licks in bursts0.10.10.2-0.40.2
Cd content in liver0.00.00.1-0.20.2
Co content in liver0.60.71.10.6-1.0
Cu content in liver0.00.00.0-0.2-0.2
Fe content in liver1.01.21.31.2-1.1
K content in liver1.61.52.0-1.41.0
Mg content in liver1.21.22.0-1.40.6
Mn content in liver2.93.33.9-2.01.6
Na content in liver0.20.20.3-0.50.4
Rb content in liver1.51.82.1-1.41.3
Se content in liver5.76.98.3-2.92.4
Sr content in liver0.20.20.2-0.50.4
Zn content in liver3.84.24.3-2.12.0
Bone: minimum diameter0.50.91.21.1-0.8
Time in familiar zone, hab. session 10.20.20.4-0.10.6
Time in novel zone, hab. session 10.50.50.7-0.90.5
Total zone transitions, hab. session 11.82.62.61.6-1.6
Total locomotion distance, hab. session 10.00.00.00.1-0.1
Locomotion velocity, hab. session 10.20.30.40.5-0.7
Time in familiar zone, hab. session 20.30.40.5-0.70.5
Time in novel zone, hab. session 20.30.30.4-0.50.6
Total zone transitions, hab. session 20.91.21.51.2-1.0
Total locomotion distance, hab. session 20.20.20.40.6-0.3
Locomotion velocity, hab. session 20.40.50.70.8-0.5
Novel to familiar place preference ratio1.21.21.70.9-1.3
Novelty place preference1.01.01.50.7-1.2
Time in novel zone, NPP test0.40.40.70.4-0.9
Total zone transitions, NPP test0.50.61.11.0-0.4
Total locomotion distance, NPP test0.10.10.10.30.3
Locomotion velocity, NPP test0.30.40.60.8-0.3
Intraocular pressure3.14.34.32.1-2.1
Delta distance traveled before/after self-admin1.71.82.21.2-1.5
Delta ambulatory time before/after self-admin1.21.31.61.1-1.2
Parametrial fat weight2.03.94.2-1.92.1
Pavlov. Cond. lever latency2.83.54.41.6-2.1
Pavlov. Cond. magazine entry latency9.812.612.8-3.53.6
Pavlov. Cond. change in total contacts8.48.99.4-3.12.9
Pavlov. Cond. index score8.010.111.3-3.03.4
Pavlov. Cond. latency score5.97.58.5-2.52.9
Pavlov. Cond. lever contacts2.32.73.7-1.31.9
Pavlov. Cond. magazine entry number12.014.915.23.8-3.9
Pavlov. Cond. intertrial magazine entries1.51.82.31.2-1.5
Pavlov. Cond. lever-magazine prob. diff.9.011.212.3-3.23.5
Pavlov. Cond. response bias9.111.011.5-3.23.4
Pavlov. Cond. lever latency0.50.60.90.6-0.9
Pavlov. Cond. magazine entry latency0.10.10.20.4-0.2
Pavlov. Cond. change in total contacts0.81.11.4-0.81.2
Pavlov. Cond. index score0.20.30.5-0.20.7
Pavlov. Cond. latency score0.10.10.3-0.10.5
Pavlov. Cond. lever contacts0.91.21.7-0.81.3
Pavlov. Cond. magazine entry number0.00.00.0-0.1-0.2
Pavlov. Cond. intertrial magazine entries1.11.51.91.0-1.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.10.5
Pavlov. Cond. response bias1.21.62.0-1.01.4
Time in closed arm before self-admin1.31.41.4-1.21.2
Time in closed arm after self-admin0.50.50.80.5-0.9
Time in open arm before self-admin1.81.92.11.5-1.3
Time in open arm after self-admin0.40.50.50.7-0.7
Bone: periosteal estimation0.20.50.70.9-0.4
Bone: periosteal perimeter0.60.91.41.2-0.6
Bone: post-yield work1.62.12.71.6-1.3
Progressive ratio test 1 active lever presses0.40.50.7-0.80.5
Progressive ratio test 1 breakpoint0.30.30.6-0.70.4
Progressive ratio test 1 inactive lever presses1.82.02.5-1.61.2
Progressive ratio test 2 active lever presses1.51.71.8-1.31.2
Progressive ratio test 2 breakpoint1.11.21.4-1.21.0
Progressive ratio test 2 inactive lever presses0.81.01.0-1.00.9
Incentive Sensitization - Responses2.22.22.6-1.41.6
Incentive Sensitization - Breakpoint2.12.12.5-1.31.6
Sum of active levers in priming session hrs 5-60.30.30.4-0.60.4
Progressive ratio0.10.20.2-0.30.5
Food seeking constrained by brief footshock0.30.40.5-0.70.6
Seeking ratio, punishment vs. effort0.00.00.00.0-0.2
Retroperitoneal fat weight0.00.00.10.2-0.2
Reaction time number correct0.81.11.61.3-0.8
Reaction time mean minus median0.20.30.30.6-0.4
Reaction time mean minus median AUC0.00.00.00.1-0.1
Reaction time num false alarms0.70.91.1-0.91.1
Reaction time num false alarms AUC0.60.91.2-0.71.1
Reaction time trials correct on left0.81.11.61.3-0.8
Reaction time trials on left0.71.11.61.2-0.7
Reaction time mean0.30.40.6-0.80.4
Reaction time mean AUC0.30.30.6-0.80.3
Median of all reaction times1.21.62.2-1.51.0
Reaction time omissions1.41.92.1-1.41.3
Reaction time false alarm rate1.21.61.7-1.31.3
Reaction time premature initiation rate0.20.30.4-0.70.3
Reaction time premature initiations0.10.10.10.3-0.3
Std. dev. reaction times0.00.00.0-0.0-0.0
Reaction time trials completed0.71.11.61.2-0.7
Reaction time trials AUC0.71.01.51.2-0.7
Run reversals in cocaine runway, females3.33.24.01.5-2.0
Run reversals in cocaine runway, males0.30.30.3-0.60.4
Latency to leave start box in cocaine runway1.61.71.91.4-1.2
Latency to leave start box in cocaine runway, F2.02.12.31.4-1.5
Latency to leave start box in cocaine runway, M0.30.30.4-0.40.6
Std. dev. time between licks in bursts0.00.00.00.00.2
Total sessions with >9 infusions0.50.60.8-0.90.6
Short access day 1 total inactive lever presses2.62.93.4-1.81.6
Short access day 10 total inactive lever presses0.00.00.00.0-0.2
Short access day 1 total infusions0.70.81.2-1.10.6
Short access day 10 total infusions0.40.50.5-0.70.7
Short access total infusions0.30.40.7-0.80.3
Short access day 1 locomotion4.65.05.0-2.22.2
Short access day 10 total locomotion1.92.12.5-1.31.6
Short access total locomotion0.80.80.8-0.90.9
One hour access (0.3 mA shock)0.00.00.0-0.1-0.0
Compulsive drug intake0.40.40.60.5-0.8
One hour access (shock baseline)0.40.40.4-0.60.7
Social response proportion0.50.60.70.7-0.8
Social responses0.00.10.1-0.00.3
Social time0.00.00.10.20.1
Soleus weight0.00.10.20.40.1
Bone: stiffness0.00.00.10.3-0.1
Tibialis anterior weight1.75.65.72.4-2.4
Time to tail flick, vehicle, before self-admin0.10.10.30.10.5
Time to tail flick, vehicle, after self-admin0.10.10.1-0.00.4
Time to tail flick, test, before self-admin1.51.51.71.3-1.1
Time to tail flick, test, after self-admin0.20.20.5-0.00.7
Delta time to tail flick, vehicle, before/after SA0.20.20.3-0.30.6
Delta time to tail flick, test, before/after SA2.72.43.1-1.31.8
Tibia length2.05.66.22.5-2.2
Ambulatory time before self-admin0.00.00.00.1-0.1
Ambulatory time after self-admin2.32.52.71.5-1.6
Bone: tissue strength0.80.81.11.0-0.7
Total heroin consumption3.03.54.5-1.62.1
Bone: trabecular number5.28.28.7-2.92.8
Bone: trabecular spacing1.72.22.71.6-1.3
Bone: trabecular thickness0.20.30.3-0.50.6
Bone: trabecular tissue density0.00.00.0-0.1-0.2
Water consumed over 24 hours0.10.10.30.50.0
Number of responses in last shaping day0.60.61.0-1.00.5