Hub : Genes

Capn11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Capn11	0.19	0.07	0.0e+00	0.18	0.18	0.18	0.18	1.6e-19	2.8e-19	2.2e-19	1.2e-19
2	Liver	alternative polyA	XM_063267563.1	0.08	0.04	2.6e-09	0.09	0.07	0.08	0.08	4.5e-10	1.8e-08	5.2e-09	3.2e-09
3	Liver	alternative polyA	XM_063267563.1	0.09	0.04	3.2e-09	0.08	0.07	0.06	0.07	2.4e-09	1.8e-08	9.6e-07	2.6e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.1	2.0	2.0	1.4	-1.4	-1.4
Area under the delay curve	1.2	1.4	1.5	1.2	-1.2	-1.2
BMI with tail	4.2	14.5	16.4	-4.1	3.7	3.7
BMI without tail	6.0	18.2	20.2	-4.5	4.1	4.1
Body weight	2.7	11.8	12.8	-3.6	3.4	3.4
Weight adjusted by age	0.1	0.1	0.1	0.3	-0.3	-0.3
Bone surface	5.1	9.2	9.4	3.0	-3.1	-3.1
Bone volume	3.8	6.9	7.0	2.6	-2.6	-2.6
Breakpoint value in progressive ratio session	1.4	1.7	1.8	1.2	-1.3	-1.3
Number of licking bursts	0.2	0.3	0.4	-0.6	0.5	0.5
Context. condit. distance diff. score	2.1	2.6	2.6	-1.6	1.6	1.6
Locomotion velocity, session 1	0.4	0.4	0.5	0.7	-0.6	-0.6
Locomotion distance, session 1	0.0	0.0	0.0	-0.1	0.2	0.2
Locomotion velocity, session 2	2.9	3.4	3.5	-1.8	1.9	1.9
Locomotion distance, session 2	0.2	0.2	0.2	-0.5	0.5	0.5
Locomotion velocity, session 3	0.1	0.1	0.1	-0.3	0.2	0.2
Locomotion distance, session 3	0.1	0.1	0.1	0.2	-0.3	-0.3
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.2	0.1	0.1
Stereotopy head waving duration, day 3	0.4	0.4	0.5	-0.7	0.6	0.6
Locomotion velocity, session 7	1.2	1.3	1.3	1.1	-1.2	-1.2
Locomotion distance, session 7	0.1	0.1	0.1	0.3	-0.3	-0.3
Stereotopy head waving bouts, day 7	0.5	0.6	0.6	-0.8	0.7	0.7
Stereotopy head waving duration, day 7	0.0	0.0	0.0	-0.2	0.2	0.2
Locomotion velocity, session 8	0.8	0.9	1.0	1.0	-1.0	-1.0
Locomotion distance, session 8	0.8	1.1	1.1	-1.1	1.1	1.1
Degree of sensitization distance	0.0	0.0	0.0	-0.2	0.2	0.2
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.4	0.3	0.3
Conditioned locomotion	1.0	1.2	1.3	1.0	-1.1	-1.1
Cocaine response after cond. corrected	0.2	0.2	0.2	0.5	-0.5	-0.5
Cocaine response after cond. not corrected	0.4	0.5	0.6	0.8	-0.6	-0.6
Cocaine response before conditioning	0.8	1.0	1.3	1.1	-0.9	-0.9
Saline control response	0.5	0.6	0.8	0.9	-0.8	-0.8
Bone: connectivity density	1.5	2.3	2.3	1.5	-1.5	-1.5
Bone: cortical apparent density	0.1	0.1	0.2	0.5	-0.3	-0.3
Bone: cortical area	0.3	0.5	0.5	0.7	-0.7	-0.7
Bone: cortical porosity	0.9	1.0	1.1	-1.1	0.9	0.9
Bone: cortical porosity	0.8	0.9	1.1	-1.0	0.9	0.9
Bone: cortical thickness	0.1	0.2	0.2	-0.4	0.5	0.5
Bone: cortical thickness	0.2	0.2	0.2	0.5	-0.5	-0.5
Bone: cortical tissue density	0.1	0.2	0.3	0.6	-0.4	-0.4
Condit. Reinf. active minus inactive responses	1.4	1.6	1.6	1.2	-1.3	-1.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.5	0.7	-0.7	-0.7
Condit. Reinf. active responses	0.7	0.8	0.8	0.9	-0.9	-0.9
Condit. Reinf. inactive responses	0.1	0.2	0.2	-0.4	0.4	0.4
Incentive salience index mean	0.4	0.5	0.5	0.7	-0.7	-0.7
Condit. Reinf. lever presses	0.3	0.4	0.4	-0.6	0.6	0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	0.6	-0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	-0.2	-0.2
Condit. Reinf. active responses	0.5	0.7	0.8	0.9	-0.8	-0.8
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.7	-0.6	-0.6
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	-0.1	-0.1
Condit. Reinf. lever reinforcers received	0.4	0.6	0.7	0.8	-0.7	-0.7
Conditioned reinforcement - actives	0.0	0.1	0.1	0.4	-0.2	-0.2
Conditioned reinforcement - inactives	0.5	0.7	0.9	-0.6	0.9	0.9
Conditioned locomotion	0.0	0.0	0.0	0.0	0.2	0.2
Patch foraging indifference point 0 sec	0.7	1.3	1.5	-1.0	1.2	1.2
Patch foraging indifference point AUC	0.0	0.0	0.0	-0.1	0.0	0.0
Delay disc. indifference point, 0s delay	2.4	2.6	2.8	1.7	-1.6	-1.6
Delay disc. indifference point, 16s delay	1.0	1.1	1.2	1.1	-1.1	-1.1
Delay disc. indifference point, 2s delay	0.4	0.4	0.6	0.8	-0.6	-0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	-0.2	0.4	0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.4	-0.3	-0.3
Delay disc. indifference point, 8s delay	2.7	3.2	3.2	1.8	-1.8	-1.8
Indifference point function ln k	0.3	0.5	0.6	-0.7	0.8	0.8
Indifference point function log k	0.3	0.5	0.6	-0.7	0.8	0.8
Patch foraging total patch changes 0 sec	0.9	1.7	1.9	-1.1	1.4	1.4
Patch foraging total patch changes 12 sec	1.0	1.3	1.4	-1.2	1.1	1.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	0.5	-0.3	-0.3
Patch foraging total patch changes 24 sec	0.6	0.9	1.0	-1.0	1.0	1.0
Patch foraging total patch changes 6 sec	1.4	2.2	2.2	-1.5	1.5	1.5
Patch foraging time to switch 0 sec	1.7	3.5	3.6	1.8	-1.9	-1.9
Patch foraging water rate 0 sec	0.6	1.2	1.2	-1.0	1.1	1.1
Patch foraging water rate 12 sec	2.1	4.3	4.3	-2.1	2.1	2.1
Patch foraging water rate 18 sec	1.3	2.1	2.2	-1.5	1.4	1.4
Patch foraging water rate 24 sec	2.9	4.0	4.2	-1.9	2.0	2.0
Patch foraging water rate 6 sec	0.0	0.0	0.0	-0.1	0.1	0.1
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	0.2	-0.3	-0.3
Distance traveled before self-admin	2.4	3.1	3.2	-1.7	1.8	1.8
Distance traveled after self-admin	0.0	0.0	0.0	-0.1	0.2	0.2
Extensor digitorum longus weight	0.2	0.7	0.9	-1.0	0.8	0.8
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.2	0.2
Bone: elastic work	0.3	0.4	0.5	-0.7	0.6	0.6
Bone: endosteal estimation	2.1	4.5	4.6	2.1	-2.1	-2.1
Bone: endosteal perimeter	2.1	4.4	4.5	2.1	-2.1	-2.1
Epididymis fat weight	6.6	22.6	24.9	-5.0	4.6	4.6
Delta time in closed arm before/after self-admin	0.4	0.3	0.4	-0.7	0.5	0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.4	-0.3	-0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	-0.2	-0.2
Delay discount exponential model param	1.0	1.1	1.2	-1.1	1.0	1.0
Extinction: sum of active levers before priming	0.9	1.0	1.1	1.0	-1.0	-1.0
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.4	0.2	0.2
Bone: final force	0.0	0.0	0.0	-0.0	0.1	0.1
Bone: final moment	0.0	0.0	0.0	-0.0	0.1	0.1
Food consumed during 24 hour testing period	0.0	0.0	0.0	0.1	0.2	0.2
Glucose	3.5	5.6	5.6	-2.3	2.4	2.4
Heart weight	0.5	0.8	0.9	-1.0	0.9	0.9
Delay discount hyperbolic model param	1.1	1.2	1.3	-1.1	1.1	1.1
Intermittent access intake day 1-15 change	0.3	0.7	0.8	0.9	-0.8	-0.8
Intermittent access intake escalation	0.4	0.8	1.1	1.0	-0.8	-0.8
Intermittent access intake escalation 2	1.9	2.2	2.6	1.6	-1.4	-1.4
Intermitt. access day 1 inactive lever presses	0.2	0.7	0.7	-0.8	0.8	0.8
Intermitt. access day 15 inactive lever presses	0.4	0.7	0.8	-0.9	0.8	0.8
Intermitt. access escalation Index	0.1	0.2	0.2	-0.4	0.5	0.5
Intermittent access day 1 total infusions	0.4	0.6	0.6	-0.7	0.8	0.8
Intermittent access day 15 total infusions	0.0	0.0	0.0	0.2	0.1	0.1
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.4	-0.2	-0.2
Intermittent access total infusions	0.0	0.0	0.0	0.1	0.1	0.1
Intermittent access day 1 locomotion	1.3	1.6	1.8	-1.3	1.2	1.2
Intermittent access day 15 total locomotion	0.0	0.0	0.0	-0.2	0.2	0.2
Intermittent access total locomotion	0.0	0.1	0.1	-0.2	0.2	0.2
Intermittent access standard deviation	0.5	1.0	1.3	1.1	-0.9	-0.9
Left kidney weight	1.0	4.5	4.5	-2.1	2.1	2.1
Right kidney weight	1.3	5.9	5.9	-2.4	2.4	2.4
Cocaine induced anxiety	0.0	0.0	0.0	-0.0	0.2	0.2
Post-drug Anxiety	0.2	0.2	0.3	0.6	-0.4	-0.4
Baseline Anxiety	2.0	2.3	2.5	1.4	-1.6	-1.6
Tail length	0.7	2.8	2.8	-1.6	1.7	1.7
Length with tail	0.3	1.2	1.3	-1.0	1.1	1.1
Length without tail	0.3	0.9	0.9	-0.9	1.0	1.0
Times rat made contact with spout	1.1	1.2	1.4	-1.0	1.2	1.2
Lifetime Intake	0.1	0.1	0.1	0.4	-0.2	-0.2
Liver weight, left	0.3	0.5	0.7	-0.5	0.8	0.8
Liver weight, right	1.0	1.7	1.9	-1.2	1.4	1.4
Locomotor activity	0.8	1.3	1.4	-1.2	1.1	1.1
Locomotor testing distance	1.0	1.7	1.9	-1.4	1.3	1.3
Locomotor testing rearing	0.4	0.9	1.1	-1.0	0.9	0.9
Locomotion in novel chamber	0.0	0.1	0.1	-0.0	-0.3	-0.3
Locomotion in novel chamber post-restriction	3.2	5.2	5.4	2.2	-2.3	-2.3
Fecal boli incidents, locomotor time 1	0.1	0.1	0.1	0.3	-0.2	-0.2
Change in fecal boli incidents, locomotor task	0.5	0.5	0.5	0.6	-0.7	-0.7
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	-0.0	-0.0	-0.0
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.5	0.3	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.1	-0.4	0.2	0.2
Rest time, locomotor task time 1	0.3	0.4	0.5	0.5	-0.7	-0.7
Distance moved, locomotor task time 1	0.8	1.2	1.3	-0.9	1.1	1.1
Vertical activity count, locomotor time 1	0.2	0.4	0.5	-0.5	0.7	0.7
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.3	0.1	0.1
Bouts of movement, locomotor time 2	0.3	0.4	0.5	-0.6	0.7	0.7
Total resting periods, locomotor time 2	0.2	0.3	0.4	-0.5	0.6	0.6
Rest time, locomotor task time 2	0.2	0.2	0.3	0.5	-0.5	-0.5
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.0	-0.0	-0.0
Vertical activity count, locomotor time 2	0.7	0.9	0.9	1.0	-1.0	-1.0
Light reinforcement 1	0.0	0.1	0.1	-0.3	0.3	0.3
Light reinforcement 2	0.2	0.2	0.3	-0.5	0.5	0.5
Bone: marrow area	2.1	4.6	4.7	2.2	-2.1	-2.1
Bone: maximum diameter	1.6	3.1	3.1	1.7	-1.8	-1.8
Bone: maximum force	0.0	0.0	0.0	0.1	-0.1	-0.1
Bone: maximum moment	0.0	0.0	0.0	0.0	-0.0	-0.0
Mean time between licks in bursts	0.6	1.5	1.5	1.2	-1.2	-1.2
Mean num. licks in bursts	0.0	0.0	0.0	0.1	0.1	0.1
Cd content in liver	1.0	1.1	1.1	1.0	-1.1	-1.1
Co content in liver	0.5	0.6	0.6	-0.8	0.8	0.8
Cu content in liver	0.5	0.6	0.7	0.7	-0.8	-0.8
Fe content in liver	0.8	1.0	1.0	-1.0	1.0	1.0
K content in liver	0.2	0.2	0.2	0.5	-0.5	-0.5
Mg content in liver	0.1	0.1	0.2	-0.4	0.4	0.4
Mn content in liver	0.1	0.1	0.2	0.4	-0.3	-0.3
Na content in liver	0.7	0.7	0.9	-0.9	0.8	0.8
Rb content in liver	2.4	2.8	2.9	1.7	-1.7	-1.7
Se content in liver	0.1	0.1	0.1	-0.3	0.2	0.2
Sr content in liver	0.0	0.0	0.0	-0.1	0.1	0.1
Zn content in liver	0.2	0.2	0.2	0.4	-0.5	-0.5
Bone: minimum diameter	1.8	3.4	3.5	1.9	-1.8	-1.8
Time in familiar zone, hab. session 1	2.7	2.6	2.7	-1.6	1.6	1.6
Time in novel zone, hab. session 1	1.7	1.7	1.9	1.4	-1.3	-1.3
Total zone transitions, hab. session 1	1.1	1.5	1.6	-1.2	1.3	1.3
Total locomotion distance, hab. session 1	1.3	1.9	2.0	-1.3	1.4	1.4
Locomotion velocity, hab. session 1	0.9	1.3	1.4	-1.1	1.2	1.2
Time in familiar zone, hab. session 2	0.0	0.0	0.0	-0.1	0.2	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.2	-0.4	0.4	0.4
Total zone transitions, hab. session 2	0.1	0.1	0.1	-0.3	0.3	0.3
Total locomotion distance, hab. session 2	0.3	0.3	0.4	-0.6	0.6	0.6
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.2	0.3	0.3
Novel to familiar place preference ratio	0.1	0.1	0.1	-0.2	0.3	0.3
Novelty place preference	0.2	0.2	0.2	-0.4	0.4	0.4
Time in novel zone, NPP test	0.3	0.3	0.4	-0.5	0.6	0.6
Total zone transitions, NPP test	0.8	1.1	1.2	-1.0	1.1	1.1
Total locomotion distance, NPP test	0.8	1.0	1.1	-0.9	1.0	1.0
Locomotion velocity, NPP test	0.6	0.8	0.9	-0.8	0.9	0.9
Intraocular pressure	0.0	0.0	0.0	-0.1	-0.1	-0.1
Delta distance traveled before/after self-admin	0.8	0.9	1.1	1.0	-0.9	-0.9
Delta ambulatory time before/after self-admin	1.3	1.6	1.9	1.4	-1.2	-1.2
Parametrial fat weight	6.1	14.4	14.9	-3.9	3.8	3.8
Pavlov. Cond. lever latency	0.3	0.4	0.4	0.6	-0.6	-0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.3	0.5	-0.5	-0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.3	0.3	0.3
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	0.2	0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	0.0	0.0	0.0
Pavlov. Cond. lever contacts	0.7	0.9	0.9	-0.9	0.9	0.9
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	-0.0	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	0.2	0.2
Pavlov. Cond. response bias	0.3	0.3	0.3	-0.6	0.6	0.6
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.2	-0.3	-0.3
Pavlov. Cond. magazine entry latency	0.7	0.8	0.8	-0.9	0.9	0.9
Pavlov. Cond. change in total contacts	0.6	1.0	1.1	-0.9	1.1	1.1
Pavlov. Cond. index score	0.8	1.1	1.1	-1.0	1.1	1.1
Pavlov. Cond. latency score	0.9	1.2	1.3	-1.1	1.1	1.1
Pavlov. Cond. lever contacts	0.2	0.3	0.3	-0.4	0.5	0.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.3	0.5	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	0.3	-0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	1.5	-1.1	1.2	1.2
Pavlov. Cond. response bias	0.0	0.0	0.0	0.0	0.1	0.1
Time in closed arm before self-admin	0.1	0.1	0.2	-0.3	0.4	0.4
Time in closed arm after self-admin	3.1	3.4	3.4	-1.8	1.8	1.8
Time in open arm before self-admin	0.3	0.3	0.4	-0.7	0.5	0.5
Time in open arm after self-admin	0.0	0.0	0.0	0.2	-0.2	-0.2
Bone: periosteal estimation	1.7	3.6	3.6	1.9	-1.9	-1.9
Bone: periosteal perimeter	0.6	1.1	1.1	1.0	-1.0	-1.0
Bone: post-yield work	0.1	0.1	0.1	-0.4	0.3	0.3
Progressive ratio test 1 active lever presses	0.8	1.0	1.1	-1.0	1.0	1.0
Progressive ratio test 1 breakpoint	0.6	0.8	0.8	-0.9	0.9	0.9
Progressive ratio test 1 inactive lever presses	1.0	1.5	1.6	-1.1	1.3	1.3
Progressive ratio test 2 active lever presses	1.6	1.8	1.9	-1.3	1.4	1.4
Progressive ratio test 2 breakpoint	2.0	2.3	2.3	-1.5	1.5	1.5
Progressive ratio test 2 inactive lever presses	0.5	0.9	1.0	-0.8	1.0	1.0
Incentive Sensitization - Responses	2.9	4.1	4.2	-1.9	2.0	2.0
Incentive Sensitization - Breakpoint	2.9	3.8	3.9	-1.9	2.0	2.0
Sum of active levers in priming session hrs 5-6	7.2	6.7	6.7	2.6	-2.6	-2.6
Progressive ratio	0.4	0.6	0.6	0.8	-0.7	-0.7
Food seeking constrained by brief footshock	0.6	0.7	0.8	0.9	-0.8	-0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	0.3	-0.3	-0.3
Retroperitoneal fat weight	3.9	16.8	18.2	-4.3	4.0	4.0
Reaction time number correct	0.1	0.2	0.2	0.4	-0.4	-0.4
Reaction time mean minus median	0.0	0.0	0.0	0.0	0.0	0.0
Reaction time mean minus median AUC	0.1	0.2	0.2	0.4	-0.4	-0.4
Reaction time num false alarms	0.0	0.0	0.0	0.1	-0.0	-0.0
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.1	0.2	0.2
Reaction time trials correct on left	0.1	0.2	0.2	0.4	-0.4	-0.4
Reaction time trials on left	0.1	0.1	0.1	0.3	-0.4	-0.4
Reaction time mean	0.6	0.9	1.0	-0.9	1.0	1.0
Reaction time mean AUC	0.4	0.7	0.7	-0.8	0.9	0.9
Median of all reaction times	0.9	1.3	1.3	-1.1	1.1	1.1
Reaction time omissions	0.7	1.0	1.1	-1.0	1.0	1.0
Reaction time false alarm rate	0.1	0.1	0.1	-0.2	0.3	0.3
Reaction time premature initiation rate	0.3	0.4	0.5	-0.7	0.6	0.6
Reaction time premature initiations	0.1	0.2	0.3	-0.6	0.4	0.4
Std. dev. reaction times	0.2	0.5	0.5	-0.7	0.7	0.7
Reaction time trials completed	0.1	0.1	0.1	0.3	-0.4	-0.4
Reaction time trials AUC	0.0	0.1	0.1	0.2	-0.2	-0.2
Run reversals in cocaine runway, females	0.4	0.4	0.6	0.8	-0.6	-0.6
Run reversals in cocaine runway, males	0.6	0.6	0.6	-0.8	0.8	0.8
Latency to leave start box in cocaine runway	0.7	0.8	1.0	-0.7	1.0	1.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.2	0.5	0.5
Latency to leave start box in cocaine runway, M	1.9	1.8	1.8	-1.3	1.3	1.3
Std. dev. time between licks in bursts	0.9	1.2	1.3	1.1	-1.1	-1.1
Total sessions with >9 infusions	0.1	0.1	0.1	0.4	-0.2	-0.2
Short access day 1 total inactive lever presses	0.5	0.7	0.8	-0.7	0.9	0.9
Short access day 10 total inactive lever presses	0.7	1.8	1.8	-1.3	1.4	1.4
Short access day 1 total infusions	0.2	0.3	0.4	-0.5	0.6	0.6
Short access day 10 total infusions	0.2	0.2	0.2	0.5	-0.4	-0.4
Short access total infusions	0.2	0.3	0.4	0.6	-0.5	-0.5
Short access day 1 locomotion	0.0	0.0	0.0	0.2	-0.1	-0.1
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	-0.1	-0.1
Short access total locomotion	0.1	0.1	0.1	0.2	-0.3	-0.3
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.1	-0.1	-0.1
Compulsive drug intake	0.0	0.0	0.1	0.1	-0.2	-0.2
One hour access (shock baseline)	0.0	0.0	0.1	0.0	0.3	0.3
Social response proportion	0.2	0.2	0.3	0.6	-0.3	-0.3
Social responses	0.1	0.1	0.1	0.2	-0.3	-0.3
Social time	0.0	0.0	0.0	-0.1	0.1	0.1
Soleus weight	0.1	0.3	0.5	-0.7	0.5	0.5
Bone: stiffness	0.0	0.0	0.0	-0.0	0.1	0.1
Tibialis anterior weight	0.5	1.6	1.8	-1.3	1.2	1.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.2	0.3	-0.5	-0.5
Time to tail flick, vehicle, after self-admin	0.7	1.0	1.1	1.1	-0.9	-0.9
Time to tail flick, test, before self-admin	4.0	4.2	4.4	2.1	-2.0	-2.0
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.3	0.6	-0.4	-0.4
Delta time to tail flick, test, before/after SA	4.3	4.5	4.6	-2.1	2.1	2.1
Tibia length	0.1	0.3	0.3	-0.4	0.6	0.6
Ambulatory time before self-admin	4.2	6.3	6.4	-2.5	2.5	2.5
Ambulatory time after self-admin	0.9	1.1	1.2	-1.0	1.1	1.1
Bone: tissue strength	0.7	0.8	0.9	-1.0	0.8	0.8
Total heroin consumption	0.2	0.3	0.3	0.5	-0.5	-0.5
Bone: trabecular number	1.2	2.0	2.0	1.4	-1.4	-1.4
Bone: trabecular spacing	1.8	2.3	2.5	-1.4	1.6	1.6
Bone: trabecular thickness	6.7	8.4	8.5	2.9	-2.9	-2.9
Bone: trabecular tissue density	0.0	0.0	0.0	0.1	0.0	0.0
Water consumed over 24 hours	1.1	1.5	1.6	-1.1	1.3	1.3
Number of responses in last shaping day	0.3	0.4	0.4	-0.5	0.7	0.7