Hub : Genes

Capn11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Capn11	0.26	0.09	0.0e+00	0.25	0.25	0.24	0.25	9.9e-28	2.4e-27	1.4e-26	7.3e-28
2	Liver	alternative polyA	XM_039084033.1	0.03	0.02	1.8e-03	0.01	0.01	0.01	0	5.5e-02	1.3e-02	4.0e-02	1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.7	1.2	1.3	1.2	-1.0
Area under the delay curve	1.1	1.2	1.3	1.1	-1.0
BMI with tail	4.4	14.1	16.2	-4.0	3.5
BMI without tail	15.8	32.5	35.2	-5.9	5.5
Body weight	2.5	10.6	11.3	-3.4	3.1
Weight adjusted by age	0.3	0.3	0.4	0.6	-0.5
Bone surface	3.7	6.6	6.8	2.6	-2.5
Bone volume	2.6	4.4	4.5	2.1	-2.1
Breakpoint value in progressive ratio session	0.3	0.3	0.5	0.7	-0.4
Number of licking bursts	0.3	0.3	0.4	-0.5	0.6
Context. condit. distance diff. score	1.7	2.1	2.8	-1.7	1.2
Locomotion velocity, session 1	0.5	0.6	0.7	0.6	-0.8
Locomotion distance, session 1	0.1	0.1	0.1	-0.3	-0.2
Locomotion velocity, session 2	2.5	2.9	3.3	-1.8	1.6
Locomotion distance, session 2	0.2	0.2	0.4	-0.6	0.3
Locomotion velocity, session 3	0.1	0.1	0.1	-0.2	0.2
Locomotion distance, session 3	0.1	0.1	0.1	0.2	-0.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.0	-0.1
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.6	0.4
Locomotion velocity, session 7	1.2	1.4	1.7	1.0	-1.3
Locomotion distance, session 7	0.3	0.4	0.7	0.2	-0.8
Stereotopy head waving bouts, day 7	0.3	0.3	0.4	-0.6	0.5
Stereotopy head waving duration, day 7	0.1	0.1	0.1	-0.2	0.3
Locomotion velocity, session 8	0.7	0.9	1.0	0.8	-1.0
Locomotion distance, session 8	0.6	0.8	1.4	-1.2	0.5
Degree of sensitization distance	0.0	0.0	0.0	-0.2	-0.1
Degree of sensitization stereotypy	0.1	0.1	0.1	-0.3	0.3
Conditioned locomotion	0.9	1.1	1.2	1.0	-1.1
Cocaine response after cond. corrected	0.1	0.2	0.3	0.5	-0.2
Cocaine response after cond. not corrected	0.5	0.5	0.7	0.9	-0.6
Cocaine response before conditioning	1.1	1.4	1.5	1.1	-1.2
Saline control response	0.3	0.5	0.6	0.8	-0.6
Bone: connectivity density	0.9	1.4	1.8	1.3	-1.0
Bone: cortical apparent density	0.2	0.3	0.3	0.5	-0.6
Bone: cortical area	0.6	0.8	1.3	0.6	-1.2
Bone: cortical porosity	1.9	2.1	2.3	-1.4	1.5
Bone: cortical porosity	0.9	1.0	1.1	-1.0	1.0
Bone: cortical thickness	0.1	0.2	0.4	-0.6	0.0
Bone: cortical thickness	0.2	0.2	0.3	0.3	-0.5
Bone: cortical tissue density	0.2	0.2	0.3	0.5	-0.5
Condit. Reinf. active minus inactive responses	2.0	2.2	2.7	1.3	-1.6
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.7	0.8	-0.9
Condit. Reinf. active responses	0.8	1.0	1.1	0.9	-1.1
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.5	0.7
Incentive salience index mean	0.6	0.8	1.0	0.7	-1.0
Condit. Reinf. lever presses	0.3	0.4	0.4	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	0.6	-1.2
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	0.3	-0.9
Condit. Reinf. active responses	0.8	1.1	1.5	0.8	-1.2
Condit. Reinf. inactive responses	0.3	0.3	0.4	0.6	-0.6
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	-0.1
Condit. Reinf. lever reinforcers received	0.7	1.0	1.4	0.8	-1.2
Conditioned reinforcement - actives	0.6	0.6	0.6	0.8	-0.8
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.1	0.0
Conditioned locomotion	0.0	0.0	0.0	0.0	0.0
Patch foraging indifference point 0 sec	0.6	1.0	1.2	-1.1	0.9
Patch foraging indifference point AUC	0.1	0.1	0.2	-0.3	-0.4
Delay disc. indifference point, 0s delay	3.4	3.8	5.1	1.6	-2.3
Delay disc. indifference point, 16s delay	0.6	0.6	1.1	1.0	-0.5
Delay disc. indifference point, 2s delay	0.7	0.7	0.8	0.8	-0.9
Delay disc. indifference point, 24s delay	0.3	0.2	0.4	-0.2	0.7
Delay disc. indifference point, 4s delay	0.3	0.4	0.6	0.4	-0.8
Delay disc. indifference point, 8s delay	2.4	2.4	2.9	1.7	-1.4
Indifference point function ln k	0.8	1.2	1.7	-0.8	1.3
Indifference point function log k	0.8	1.2	1.7	-0.8	1.3
Patch foraging total patch changes 0 sec	0.8	1.2	1.6	-1.3	0.9
Patch foraging total patch changes 12 sec	0.9	1.2	1.9	-1.4	0.7
Patch foraging total patch changes 18 sec	0.2	0.2	0.4	0.3	-0.6
Patch foraging total patch changes 24 sec	0.7	0.9	1.3	-1.2	0.6
Patch foraging total patch changes 6 sec	1.1	1.6	2.3	-1.5	1.0
Patch foraging time to switch 0 sec	1.5	2.3	3.6	1.9	-1.0
Patch foraging water rate 0 sec	0.5	0.7	1.4	-1.2	0.1
Patch foraging water rate 12 sec	2.1	3.2	5.0	-2.2	1.2
Patch foraging water rate 18 sec	1.6	2.2	2.8	-1.7	1.2
Patch foraging water rate 24 sec	2.8	3.8	5.3	-2.3	1.5
Patch foraging water rate 6 sec	0.1	0.2	0.4	-0.3	-0.6
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	0.0	0.1
Distance traveled before self-admin	0.9	1.0	1.5	-1.2	0.8
Distance traveled after self-admin	0.0	0.0	0.1	-0.3	0.2
Extensor digitorum longus weight	0.1	0.4	0.8	-0.9	0.4
Bone: elastic displacement	0.2	0.2	0.3	-0.3	0.6
Bone: elastic work	0.6	0.8	1.0	-0.8	1.0
Bone: endosteal estimation	1.6	3.4	3.5	1.9	-1.8
Bone: endosteal perimeter	2.2	4.6	4.6	2.1	-2.1
Epididymis fat weight	3.7	8.7	8.9	-2.9	3.0
Delta time in closed arm before/after self-admin	1.1	1.1	1.3	-1.0	1.1
Delta time in open arm before/after self-admin	0.2	0.2	0.2	0.5	-0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.5	-0.1
Delay discount exponential model param	0.9	0.9	1.1	-1.1	0.9
Extinction: sum of active levers before priming	0.9	0.9	1.0	1.0	-0.9
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.1	0.3
Bone: final force	0.1	0.2	0.3	-0.1	-0.5
Bone: final moment	0.1	0.2	0.4	-0.2	-0.6
Food consumed during 24 hour testing period	0.0	0.0	0.0	-0.1	0.1
Glucose	2.6	4.0	4.9	-2.2	1.7
Heart weight	1.0	1.5	1.6	1.2	-1.2
Delay discount hyperbolic model param	1.1	1.1	1.3	-1.1	1.0
Intermittent access intake day 1-15 change	0.2	0.2	0.2	0.5	-0.4
Intermittent access intake escalation	0.8	0.8	1.0	1.0	-0.7
Intermittent access intake escalation 2	0.3	0.3	0.4	0.6	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.3
Intermitt. access day 15 inactive lever presses	0.4	0.5	0.7	-0.9	0.5
Intermitt. access escalation Index	1.2	1.1	1.4	-1.2	0.9
Intermittent access day 1 total infusions	0.8	0.9	1.5	-0.6	1.2
Intermittent access day 15 total infusions	0.1	0.1	0.1	0.3	0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	0.0	0.6
Intermittent access total infusions	0.4	0.4	0.8	-0.1	0.9
Intermittent access day 1 locomotion	0.8	0.8	1.1	-0.7	1.1
Intermittent access day 15 total locomotion	0.2	0.2	0.3	0.6	-0.1
Intermittent access total locomotion	0.2	0.2	0.4	0.6	-0.1
Intermittent access standard deviation	0.4	0.4	0.8	0.9	-0.2
Left kidney weight	0.4	1.1	1.1	-1.1	1.0
Right kidney weight	0.2	0.5	0.7	-0.8	0.5
Cocaine induced anxiety	0.0	0.0	0.1	0.2	-0.0
Post-drug Anxiety	0.6	0.6	0.9	1.0	-0.6
Baseline Anxiety	1.1	1.1	1.4	1.2	-0.9
Tail length	2.2	6.5	6.9	-2.5	2.6
Length with tail	0.0	0.0	0.0	0.2	0.2
Length without tail	2.9	6.3	7.1	2.7	-2.4
Times rat made contact with spout	0.9	1.1	1.2	-0.9	1.1
Lifetime Intake	0.1	0.1	0.1	0.3	0.4
Liver weight, left	0.2	0.4	0.6	-0.8	0.4
Liver weight, right	0.2	0.3	0.3	-0.6	0.6
Locomotor activity	1.0	1.5	1.6	-1.2	1.2
Locomotor testing distance	0.6	1.0	1.4	-1.2	0.8
Locomotor testing rearing	0.7	1.1	1.8	-1.4	0.6
Locomotion in novel chamber	0.0	0.0	0.1	-0.1	0.2
Locomotion in novel chamber post-restriction	3.7	4.4	5.9	2.4	-1.7
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	0.2	-0.7
Change in fecal boli incidents, locomotor task	0.5	0.5	0.9	1.0	-0.2
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.1	-0.2
Bouts of movement, locomotor time 1	0.2	0.3	0.4	-0.6	0.4
Total resting periods, locomotor time 1	0.1	0.2	0.3	-0.6	0.1
Rest time, locomotor task time 1	0.5	0.6	1.0	0.5	-1.0
Distance moved, locomotor task time 1	0.6	0.6	0.8	-0.7	0.9
Vertical activity count, locomotor time 1	0.5	0.6	1.0	-0.3	1.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	-0.1	0.1
Bouts of movement, locomotor time 2	0.5	0.5	0.5	-0.7	0.7
Total resting periods, locomotor time 2	0.5	0.5	0.5	-0.7	0.7
Rest time, locomotor task time 2	0.1	0.2	0.2	0.3	-0.5
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	-0.1
Vertical activity count, locomotor time 2	0.9	1.0	1.4	1.2	-0.8
Light reinforcement 1	0.2	0.4	0.4	-0.6	0.6
Light reinforcement 2	0.3	0.3	0.4	-0.6	0.6
Bone: marrow area	1.7	3.6	3.6	1.9	-1.9
Bone: maximum diameter	1.9	3.5	4.2	1.7	-2.0
Bone: maximum force	0.0	0.1	0.1	-0.0	-0.3
Bone: maximum moment	0.0	0.1	0.1	-0.1	-0.3
Mean time between licks in bursts	0.8	1.1	1.4	1.2	-0.9
Mean num. licks in bursts	0.0	0.0	0.0	0.0	-0.0
Cd content in liver	1.7	1.9	2.1	1.5	-1.3
Co content in liver	0.8	1.0	1.3	-0.8	1.2
Cu content in liver	0.6	0.7	0.7	0.8	-0.8
Fe content in liver	0.2	0.3	0.3	-0.5	0.5
K content in liver	0.1	0.1	0.1	0.2	0.4
Mg content in liver	0.0	0.0	0.0	0.1	0.2
Mn content in liver	0.0	0.0	0.0	-0.1	0.1
Na content in liver	0.4	0.4	0.5	-0.7	0.5
Rb content in liver	2.3	2.8	4.0	2.0	-1.3
Se content in liver	0.1	0.1	0.2	0.1	-0.5
Sr content in liver	0.0	0.0	0.1	-0.1	-0.3
Zn content in liver	2.6	2.9	3.4	1.5	-1.9
Bone: minimum diameter	1.8	3.4	3.7	1.7	-1.9
Time in familiar zone, hab. session 1	3.2	3.0	3.1	-1.7	1.8
Time in novel zone, hab. session 1	2.5	2.4	2.6	1.5	-1.6
Total zone transitions, hab. session 1	0.6	0.9	1.4	-1.2	0.7
Total locomotion distance, hab. session 1	0.6	0.9	1.5	-1.2	0.5
Locomotion velocity, hab. session 1	0.4	0.5	1.0	-1.0	0.3
Time in familiar zone, hab. session 2	0.4	0.5	0.9	-0.2	1.0
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.4	-0.6
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	0.1
Total locomotion distance, hab. session 2	0.2	0.2	0.4	-0.6	0.4
Locomotion velocity, hab. session 2	0.0	0.1	0.1	-0.3	0.2
Novel to familiar place preference ratio	0.0	0.0	0.0	-0.1	0.2
Novelty place preference	0.1	0.1	0.2	-0.3	0.4
Time in novel zone, NPP test	0.2	0.2	0.2	-0.4	0.4
Total zone transitions, NPP test	0.5	0.7	1.2	-1.1	0.5
Total locomotion distance, NPP test	0.4	0.6	1.0	-1.0	0.4
Locomotion velocity, NPP test	0.4	0.5	0.9	-0.9	0.4
Intraocular pressure	0.0	0.0	0.1	0.3	-0.1
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.4	-0.1
Delta ambulatory time before/after self-admin	0.4	0.4	0.7	0.9	-0.4
Parametrial fat weight	5.0	9.7	11.5	-3.4	2.8
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.5	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.3	-0.6
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.3	0.0
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.1	0.0	-0.4
Pavlov. Cond. lever contacts	0.5	0.5	0.6	-0.8	0.7
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	-0.2	0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	-0.4	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.1	-0.2
Pavlov. Cond. response bias	0.3	0.3	0.4	-0.6	0.5
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.2	0.3
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	-0.8	0.2
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	-0.9	0.5
Pavlov. Cond. index score	0.5	0.6	1.1	-1.1	0.4
Pavlov. Cond. latency score	0.7	0.8	1.4	-1.2	0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	0.1
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.7	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.5	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.5	-1.2	0.6
Pavlov. Cond. response bias	0.1	0.1	0.2	0.0	-0.5
Time in closed arm before self-admin	0.1	0.1	0.2	0.2	-0.5
Time in closed arm after self-admin	1.4	1.4	2.0	-1.4	0.9
Time in open arm before self-admin	0.2	0.2	0.3	-0.4	0.5
Time in open arm after self-admin	0.0	0.0	0.1	0.3	-0.1
Bone: periosteal estimation	1.7	3.5	4.2	1.7	-2.0
Bone: periosteal perimeter	0.8	1.3	1.5	1.0	-1.2
Bone: post-yield work	0.1	0.1	0.1	-0.3	0.3
Progressive ratio test 1 active lever presses	0.6	0.6	0.9	-0.6	1.0
Progressive ratio test 1 breakpoint	0.5	0.5	0.8	-0.4	0.9
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.6	-0.7	0.8
Progressive ratio test 2 active lever presses	0.5	0.6	0.8	-0.6	0.9
Progressive ratio test 2 breakpoint	0.9	1.0	1.2	-0.9	1.1
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.3	-0.4	0.5
Incentive Sensitization - Responses	1.7	1.7	1.9	-1.4	1.2
Incentive Sensitization - Breakpoint	1.3	1.3	1.5	-1.2	1.1
Sum of active levers in priming session hrs 5-6	6.8	6.6	8.5	2.9	-2.2
Progressive ratio	0.6	0.7	0.8	0.8	-0.9
Food seeking constrained by brief footshock	1.3	1.6	2.1	1.4	-1.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	-0.0
Retroperitoneal fat weight	1.3	4.2	5.6	-2.4	1.7
Reaction time number correct	0.4	0.6	1.1	0.2	-1.0
Reaction time mean minus median	0.0	0.1	0.1	0.1	-0.3
Reaction time mean minus median AUC	0.3	0.4	0.4	0.5	-0.7
Reaction time num false alarms	0.0	0.0	0.0	0.0	-0.0
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.2	0.3
Reaction time trials correct on left	0.4	0.6	1.1	0.2	-1.0
Reaction time trials on left	0.3	0.5	0.9	0.2	-1.0
Reaction time mean	0.7	0.9	1.4	-0.7	1.2
Reaction time mean AUC	0.4	0.6	0.8	-0.6	0.9
Median of all reaction times	1.2	1.6	2.4	-0.9	1.5
Reaction time omissions	0.8	1.2	1.3	-1.0	1.1
Reaction time false alarm rate	0.1	0.2	0.4	-0.2	0.6
Reaction time premature initiation rate	0.3	0.3	0.5	-0.7	0.4
Reaction time premature initiations	0.2	0.2	0.4	-0.7	-0.0
Std. dev. reaction times	0.2	0.3	0.4	-0.5	0.7
Reaction time trials completed	0.3	0.5	0.9	0.2	-1.0
Reaction time trials AUC	0.3	0.4	0.9	0.1	-0.9
Run reversals in cocaine runway, females	0.8	0.8	0.8	0.9	-0.9
Run reversals in cocaine runway, males	0.5	0.5	0.9	-0.9	0.2
Latency to leave start box in cocaine runway	0.8	0.8	1.0	-1.0	0.8
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	-0.2	-0.1
Latency to leave start box in cocaine runway, M	2.4	2.4	2.8	-1.7	1.4
Std. dev. time between licks in bursts	1.0	1.2	1.4	1.2	-1.0
Total sessions with >9 infusions	0.1	0.1	0.2	-0.4	0.3
Short access day 1 total inactive lever presses	0.0	0.0	0.1	-0.3	0.1
Short access day 10 total inactive lever presses	0.1	0.1	0.2	-0.5	0.1
Short access day 1 total infusions	0.1	0.1	0.1	-0.4	0.3
Short access day 10 total infusions	0.2	0.2	0.4	0.1	0.6
Short access total infusions	0.0	0.0	0.0	0.2	0.1
Short access day 1 locomotion	0.3	0.3	0.5	0.4	-0.7
Short access day 10 total locomotion	0.4	0.4	0.6	0.8	-0.5
Short access total locomotion	0.6	0.6	0.6	0.7	-0.8
One hour access (0.3 mA shock)	0.4	0.5	0.7	0.9	-0.5
Compulsive drug intake	0.5	0.5	0.7	0.6	-0.8
One hour access (shock baseline)	0.3	0.3	0.6	-0.2	0.8
Social response proportion	0.2	0.2	0.4	0.6	0.0
Social responses	0.1	0.1	0.2	0.5	0.1
Social time	0.0	0.1	0.1	0.0	-0.3
Soleus weight	0.1	0.3	0.6	-0.8	0.3
Bone: stiffness	0.0	0.0	0.0	-0.1	-0.1
Tibialis anterior weight	0.2	0.7	1.2	-1.1	0.4
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.2	-0.1
Time to tail flick, vehicle, after self-admin	0.9	0.9	1.2	1.1	-0.8
Time to tail flick, test, before self-admin	4.4	4.3	4.7	2.0	-2.2
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.0	-0.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	1.0	-0.7
Delta time to tail flick, test, before/after SA	4.3	3.8	4.1	-2.0	1.9
Tibia length	0.0	0.1	0.1	-0.4	-0.3
Ambulatory time before self-admin	2.1	2.2	3.2	-1.8	1.1
Ambulatory time after self-admin	0.4	0.4	0.7	-0.9	0.3
Bone: tissue strength	0.6	0.6	0.7	-0.8	0.8
Total heroin consumption	0.1	0.1	0.2	0.1	0.4
Bone: trabecular number	1.1	1.8	1.9	1.3	-1.4
Bone: trabecular spacing	1.6	2.1	2.4	-1.5	1.3
Bone: trabecular thickness	5.2	6.2	6.5	2.6	-2.4
Bone: trabecular tissue density	0.3	0.5	0.9	-0.0	-1.0
Water consumed over 24 hours	0.8	0.9	0.9	-1.0	1.0
Number of responses in last shaping day	0.4	0.4	0.5	-0.7	0.5