Hub : Genes

Cacng5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc alternative polyA NM_080693.2 0.07 0.03 1.0e-10 0.09 0.09 0.08 0.08 2.8e-10 4.3e-10 2.1e-09 1.4e-09
2 NAcc alternative polyA XM_039085092.1 0.07 0.03 1.0e-10 0.09 0.09 0.08 0.08 2.4e-10 3.6e-10 1.6e-09 1.5e-09
3 PL alternative polyA NM_080693.2 0.05 0.03 7.7e-07 0.06 0.06 0.06 0.06 1.0e-07 9.7e-07 6.1e-07 4.2e-07
4 PL alternative polyA XM_039085092.1 0.06 0.03 2.5e-07 0.07 0.06 0.07 0.07 2.1e-08 3.7e-07 1.0e-07 7.4e-08
5 NAcc mRNA stability Cacng5 0.03 0.02 2.3e-03 0.02 0.02 0.01 0.01 3.1e-03 2.1e-03 1.9e-02 1.7e-02
6 Brain alternative polyA XM_039085092.1 0.04 0.02 1.5e-04 0.03 0.04 0.02 0.03 1.2e-03 2.4e-04 3.3e-03 8.1e-04
7 Brain alternative polyA NM_080693.2 0.04 0.02 1.4e-04 0.04 0.04 0.02 0.03 3.1e-04 2.3e-04 2.7e-03 6.0e-04
8 BLA alternative polyA NM_080693.2 0.09 0.05 7.5e-05 0.05 0.06 0.06 0.06 8.8e-04 2.9e-04 4.0e-04 3.7e-04
9 Brain gene expression Cacng5 0.05 0.03 3.4e-04 0.03 0.02 0.01 0.02 8.2e-04 2.9e-03 2.9e-02 7.2e-03
10 BLA alternative polyA XM_039085092.1 0.08 0.05 1.1e-04 0.05 0.05 0.04 0.05 1.6e-03 7.2e-04 4.6e-03 9.6e-04
11 PL gene expression Cacng5 0.14 0.06 2.6e-09 0.07 0.09 0.09 0.08 5.4e-08 1.6e-10 1.1e-09 8.2e-09
12 BLA gene expression Cacng5 0.22 0.09 1.7e-06 0.06 0.05 0.07 0.07 4.6e-04 1.1e-03 1.3e-04 9.8e-05
13 LHb alternative polyA NM_080693.2 0.32 0.17 6.5e-04 0.01 0.09 0.14 0.1 1.9e-01 4.0e-03 2.8e-04 2.0e-03
14 LHb alternative polyA XM_039085092.1 0.27 0.15 9.9e-04 0.01 0.09 0.15 0.1 1.8e-01 4.4e-03 2.5e-04 2.5e-03
15 NAcc gene expression Cacng5 0.05 0.03 3.1e-03 0.03 0 0.01 0.01 2.4e-04 7.7e-02 4.9e-02 8.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.71.2-1.11.1-1.11.1-0.9-0.70.81.00.6-1.1-0.7-0.9-0.10.00.8
Area under the delay curve0.50.51.70.6-0.60.7-0.70.60.5-0.5-0.3-0.40.2-0.9-1.11.0-0.91.3
BMI with tail0.62.19.9-0.10.1-0.10.12.0-0.30.3-1.3-0.21.4-3.1-1.3-2.02.21.7
BMI without tail2.04.112.2-2.22.2-2.22.20.1-2.12.10.91.5-0.8-3.5-2.5-2.02.02.0
Body weight1.04.27.3-2.42.4-2.42.4-0.6-2.42.41.02.0-0.9-2.7-2.0-2.02.21.3
Weight adjusted by age2.83.15.32.3-2.32.1-2.11.92.1-2.1-2.2-2.02.10.51.10.8-0.50.1
Bone surface2.95.110.4-2.92.9-2.92.9-3.2-2.42.32.81.9-2.90.6-0.4-0.60.5-0.7
Bone volume2.13.66.2-2.52.5-2.52.5-2.5-2.02.02.41.6-2.4-0.3-1.0-0.10.10.3
Breakpoint value in progressive ratio session1.01.12.20.9-0.90.9-0.90.80.9-0.9-1.0-1.11.11.21.5-1.21.1-1.2
Number of licking bursts0.10.10.3-0.40.4-0.40.4-0.2-0.00.00.00.3-0.00.50.30.2-0.3-0.5
Context. condit. distance diff. score0.10.10.40.3-0.30.3-0.30.50.2-0.2-0.40.20.4-0.3-0.30.6-0.60.4
Locomotion velocity, session 10.10.10.3-0.50.5-0.50.5-0.5-0.30.30.30.1-0.30.40.4-0.1-0.1-0.5
Locomotion distance, session 10.10.10.4-0.10.1-0.10.1-0.10.2-0.2-0.1-0.20.20.40.70.0-0.2-0.5
Locomotion velocity, session 21.21.47.5-0.60.6-0.60.6-1.2-0.50.50.60.1-0.52.22.1-0.40.3-2.7
Locomotion distance, session 20.30.52.80.0-0.00.1-0.1-0.20.1-0.1-0.1-0.30.21.31.5-0.10.0-1.7
Locomotion velocity, session 31.92.22.91.6-1.61.7-1.71.61.6-1.6-1.7-1.41.70.51.21.6-1.6-0.5
Locomotion distance, session 30.60.73.00.6-0.60.6-0.60.20.7-0.7-0.5-0.30.50.90.71.7-1.7-0.6
Stereotopy head waving bouts, day 31.41.74.11.6-1.61.7-1.71.51.6-1.5-1.1-2.01.1-0.10.30.3-0.50.7
Stereotopy head waving duration, day 31.41.63.41.5-1.51.6-1.61.41.4-1.4-1.1-1.81.0-0.20.11.1-1.10.8
Locomotion velocity, session 70.40.51.00.4-0.40.5-0.50.60.8-0.8-0.8-0.90.80.61.0-0.70.5-0.7
Locomotion distance, session 70.10.10.3-0.30.3-0.20.2-0.3-0.30.30.30.5-0.3-0.1-0.30.0-0.00.0
Stereotopy head waving bouts, day 72.52.85.02.2-2.22.2-2.21.51.7-1.7-1.6-1.51.60.91.41.4-1.2-0.8
Stereotopy head waving duration, day 74.25.18.32.9-2.92.9-2.91.72.3-2.3-2.0-2.12.01.92.31.9-1.7-1.4
Locomotion velocity, session 80.20.31.2-0.40.4-0.40.4-0.6-0.10.00.20.0-0.21.01.00.1-0.3-1.1
Locomotion distance, session 80.10.21.1-0.20.2-0.20.2-0.3-0.20.20.10.4-0.10.80.80.3-0.3-1.0
Degree of sensitization distance0.80.81.9-0.80.8-0.80.8-0.6-0.90.90.80.7-0.8-0.7-0.9-1.41.30.5
Degree of sensitization stereotypy2.73.04.72.2-2.22.1-2.11.31.5-1.5-1.7-1.21.71.62.11.4-1.2-1.7
Conditioned locomotion0.00.10.2-0.10.1-0.10.1-0.1-0.20.20.3-0.1-0.3-0.3-0.2-0.40.40.1
Cocaine response after cond. corrected0.20.20.90.6-0.60.6-0.60.30.4-0.4-0.30.20.30.2-0.10.9-0.80.1
Cocaine response after cond. not corrected1.01.13.01.0-1.01.0-1.00.10.8-0.8-0.70.00.71.71.41.2-1.1-1.6
Cocaine response before conditioning0.91.14.00.6-0.60.6-0.6-0.20.6-0.7-0.5-0.40.52.01.90.9-1.1-2.0
Saline control response0.40.52.1-0.50.5-0.50.50.4-0.80.8-0.00.60.1-1.4-0.8-1.01.10.7
Bone: connectivity density0.81.22.5-1.41.4-1.31.3-1.4-1.11.11.50.6-1.6-0.1-0.4-0.70.60.2
Bone: cortical apparent density2.63.48.51.7-1.71.7-1.72.91.5-1.5-1.7-1.31.7-2.5-1.70.8-0.82.8
Bone: cortical area1.32.03.5-1.71.7-1.61.6-1.0-1.91.91.41.5-1.4-1.5-1.4-0.30.50.7
Bone: cortical porosity3.03.37.0-2.02.0-2.02.0-2.6-1.91.81.81.4-1.81.71.2-0.90.8-2.3
Bone: cortical porosity1.71.94.1-1.61.6-1.61.6-2.0-1.51.51.41.2-1.31.10.6-0.00.2-1.6
Bone: cortical thickness2.43.912.32.0-2.02.0-2.03.51.5-1.4-2.4-1.62.4-2.6-1.00.6-0.32.0
Bone: cortical thickness0.60.72.40.7-0.70.7-0.71.60.4-0.4-0.9-0.40.9-1.5-0.4-0.20.30.9
Bone: cortical tissue density2.43.28.11.7-1.71.7-1.72.81.5-1.4-1.7-1.31.6-2.4-1.60.8-0.72.7
Condit. Reinf. active minus inactive responses2.22.54.6-1.81.8-1.81.8-2.2-1.81.81.82.0-1.80.8-0.20.8-0.7-1.1
Condit. Reinf. active-inactive response ratio0.90.91.9-1.11.1-1.11.1-1.4-0.90.91.11.1-1.10.8-0.00.6-0.6-0.7
Condit. Reinf. active responses2.32.85.2-1.81.8-1.81.8-2.3-2.02.02.02.1-1.90.8-0.20.5-0.3-1.3
Condit. Reinf. inactive responses0.50.61.3-0.70.7-0.70.7-1.0-1.21.11.01.1-1.00.1-0.2-0.10.3-0.5
Incentive salience index mean1.31.62.9-1.41.4-1.31.3-1.7-1.51.41.41.6-1.30.90.30.4-0.3-1.3
Condit. Reinf. lever presses0.30.32.00.3-0.30.3-0.30.00.0-0.1-0.40.10.41.01.2-0.00.2-1.4
Condit. Reinf. active minus inactive responses3.94.89.4-2.32.3-2.32.3-3.1-2.52.52.62.9-2.61.1-0.11.4-1.1-1.6
Condit. Reinf. active-inactive response ratio2.42.55.6-1.61.6-1.61.6-2.4-1.81.71.82.1-1.81.10.20.7-0.5-1.5
Condit. Reinf. active responses4.66.411.4-2.92.9-2.92.9-3.4-3.03.03.03.3-3.00.8-0.40.7-0.5-1.5
Condit. Reinf. inactive responses1.92.33.6-1.91.9-1.91.9-1.6-1.91.91.81.7-1.8-0.3-0.7-0.40.4-0.3
Condit. Reinf. lever presses2.94.08.5-2.32.3-2.32.3-2.3-2.72.62.22.9-2.1-0.0-0.50.30.0-1.1
Condit. Reinf. lever reinforcers received4.36.111.2-2.82.8-2.82.8-3.3-3.03.03.03.3-2.90.5-0.60.7-0.4-1.3
Conditioned reinforcement - actives0.50.51.0-1.01.0-1.01.0-0.8-0.70.71.00.5-1.0-0.1-0.10.2-0.4-0.1
Conditioned reinforcement - inactives0.80.91.8-1.21.2-1.31.3-0.9-1.01.00.90.9-0.9-0.7-0.7-0.1-0.10.3
Conditioned locomotion2.53.04.9-2.22.2-2.22.2-1.6-1.91.91.91.7-1.9-1.5-1.7-0.60.21.0
Patch foraging indifference point 0 sec5.69.013.9-3.53.5-3.53.5-2.6-3.73.73.23.7-3.2-2.2-3.0-0.71.01.4
Patch foraging indifference point AUC0.50.61.3-1.21.2-1.11.1-0.5-0.80.80.60.7-0.6-0.4-0.50.2-0.5-0.1
Delay disc. indifference point, 0s delay0.80.81.31.1-1.11.1-1.10.91.1-1.1-1.0-1.20.90.10.30.7-0.50.6
Delay disc. indifference point, 16s delay0.50.52.40.2-0.20.2-0.20.5-0.00.0-0.00.1-0.0-1.5-1.50.6-0.41.5
Delay disc. indifference point, 2s delay0.50.51.7-0.60.6-0.50.5-0.6-0.40.40.90.4-1.0-0.7-1.30.3-0.41.3
Delay disc. indifference point, 24s delay1.51.45.4-1.01.0-0.90.9-0.0-0.90.90.70.9-0.7-2.3-2.30.0-0.02.0
Delay disc. indifference point, 4s delay1.01.01.71.3-1.31.3-1.30.61.1-1.1-0.8-0.90.80.80.81.3-1.0-0.1
Delay disc. indifference point, 8s delay1.41.52.21.2-1.21.4-1.41.51.1-1.1-1.0-1.10.9-1.2-1.11.2-1.11.5
Indifference point function ln k0.20.30.91.0-1.00.9-0.90.40.5-0.5-0.2-0.30.20.20.20.3-0.10.1
Indifference point function log k0.20.30.91.0-1.00.9-0.90.40.5-0.5-0.2-0.30.20.20.20.3-0.10.1
Patch foraging total patch changes 0 sec5.48.613.9-3.43.4-3.43.4-2.5-3.63.63.13.7-3.1-2.2-2.9-0.71.01.4
Patch foraging total patch changes 12 sec4.96.39.5-3.13.1-3.03.0-2.5-3.13.12.93.0-2.8-1.3-2.3-0.50.60.8
Patch foraging total patch changes 18 sec1.11.42.6-1.41.4-1.31.3-1.0-1.61.61.11.6-1.1-0.9-0.90.00.10.1
Patch foraging total patch changes 24 sec3.03.76.0-2.52.5-2.42.4-1.6-2.22.31.92.4-1.9-1.6-1.8-0.10.10.8
Patch foraging total patch changes 6 sec4.46.611.1-3.13.1-3.13.1-2.3-3.23.22.63.3-2.6-1.5-2.3-0.40.70.7
Patch foraging time to switch 0 sec0.20.30.60.7-0.70.8-0.80.50.5-0.5-0.6-0.20.6-0.00.10.10.10.2
Patch foraging water rate 0 sec1.82.94.7-2.02.0-2.22.2-1.4-2.02.01.81.6-1.8-1.2-1.5-1.21.10.6
Patch foraging water rate 12 sec0.10.10.30.0-0.0-0.00.00.50.3-0.3-0.5-0.50.5-0.40.2-0.30.20.1
Patch foraging water rate 18 sec0.10.10.6-0.30.3-0.40.40.1-0.20.20.20.0-0.2-0.4-0.3-0.80.70.4
Patch foraging water rate 24 sec0.20.31.10.5-0.50.5-0.50.40.8-0.8-0.4-1.00.40.70.6-0.3-0.0-0.2
Patch foraging water rate 6 sec0.20.30.70.7-0.70.7-0.70.80.3-0.3-0.4-0.50.4-0.5-0.2-0.60.70.5
Seeking ratio, delayed vs. immediate footshock0.20.21.20.1-0.10.2-0.20.50.2-0.2-0.3-0.10.3-1.0-0.70.2-0.21.1
Distance traveled before self-admin1.51.64.51.4-1.41.0-1.00.41.2-1.2-0.8-1.10.81.51.22.0-2.1-1.0
Distance traveled after self-admin1.11.23.61.0-1.00.6-0.60.00.8-0.8-0.6-0.70.71.91.61.4-1.4-1.6
Extensor digitorum longus weight1.56.110.72.4-2.42.4-2.43.22.6-2.5-3.3-2.73.3-1.10.7-2.62.51.2
Bone: elastic displacement0.91.01.31.0-1.01.0-1.01.01.0-1.0-1.0-1.11.10.71.10.8-0.9-0.9
Bone: elastic work0.20.20.7-0.50.5-0.50.50.3-0.30.40.0-0.00.0-0.9-0.3-0.70.70.3
Bone: endosteal estimation11.424.851.4-6.06.0-6.06.0-7.2-5.75.66.05.2-6.01.6-0.7-1.71.8-2.3
Bone: endosteal perimeter9.519.740.9-5.45.4-5.45.4-6.4-5.04.95.44.6-5.41.1-1.1-0.91.0-1.5
Epididymis fat weight1.02.48.7-0.60.6-0.60.61.2-0.40.5-0.60.00.6-3.0-2.0-2.62.82.3
Delta time in closed arm before/after self-admin0.20.20.80.4-0.40.5-0.5-0.30.4-0.40.0-0.3-0.00.90.50.5-0.7-0.5
Delta time in open arm before/after self-admin0.90.92.50.9-0.91.0-1.00.90.8-0.8-0.6-0.80.6-0.5-0.11.6-1.50.9
Diff in mean of infusions in LGA sessions1.11.32.61.1-1.11.0-1.01.61.2-1.2-1.6-1.51.6-0.40.4-1.00.70.2
Delay discount exponential model param0.30.31.4-0.20.2-0.40.4-0.3-0.20.2-0.00.10.10.91.1-0.90.7-1.2
Extinction: sum of active levers before priming0.20.21.00.4-0.40.3-0.30.40.1-0.1-0.2-0.10.3-0.2-0.0-0.91.00.4
Active lever presses in extinction session 61.61.53.4-1.61.6-1.61.6-0.9-1.21.21.11.0-1.0-0.5-0.4-1.81.6-0.3
Bone: final force1.72.74.1-1.91.9-1.81.8-1.6-2.02.02.02.0-2.0-1.2-1.6-0.40.50.9
Bone: final moment1.82.94.4-1.91.9-1.91.9-1.7-2.12.12.12.0-2.1-1.1-1.6-0.40.50.8
Food consumed during 24 hour testing period1.41.74.3-1.11.1-1.11.1-0.2-1.51.50.81.0-0.8-1.9-1.4-1.82.11.0
Glucose0.91.43.71.0-1.01.0-1.01.11.6-1.6-1.5-1.91.50.71.10.5-0.8-0.3
Heart weight0.20.42.30.6-0.60.4-0.40.20.2-0.2-0.50.10.4-0.1-0.11.5-1.20.0
Delay discount hyperbolic model param0.40.41.6-0.30.3-0.50.5-0.3-0.30.30.00.20.00.91.1-0.90.7-1.3
Intermittent access intake day 1-15 change0.60.61.9-0.60.6-0.60.6-1.0-0.60.60.40.6-0.40.90.4-1.11.4-0.9
Intermittent access intake escalation0.30.30.7-0.40.4-0.40.4-0.7-0.30.30.20.4-0.10.80.4-0.60.8-0.8
Intermittent access intake escalation 21.71.72.5-1.51.5-1.51.5-1.6-1.41.41.21.5-1.20.6-0.1-1.21.3-0.9
Intermitt. access day 1 inactive lever presses1.21.32.4-1.41.4-1.51.5-1.3-1.31.31.01.2-0.90.60.30.1-0.2-1.2
Intermitt. access day 15 inactive lever presses0.20.20.4-0.50.5-0.60.6-0.1-0.50.50.10.4-0.1-0.4-0.3-0.60.5-0.0
Intermitt. access escalation Index0.80.71.90.9-0.90.9-0.90.10.7-0.7-0.5-0.40.51.41.30.8-0.7-1.2
Intermittent access day 1 total infusions0.70.81.3-0.90.9-0.90.9-0.5-1.01.00.90.7-0.9-1.2-1.00.6-0.70.8
Intermittent access day 15 total infusions1.11.22.0-1.31.3-1.41.4-1.2-1.41.41.11.3-1.1-0.5-0.8-0.20.40.1
Intermittent access terminal intake (last 3 days)2.93.25.0-2.12.1-2.12.1-2.0-2.22.22.02.2-2.0-0.8-1.3-0.70.90.3
Intermittent access total infusions2.42.74.3-1.91.9-1.91.9-1.7-2.12.11.92.0-1.9-1.0-1.40.10.00.5
Intermittent access day 1 locomotion1.92.03.1-1.71.7-1.71.7-1.1-1.61.61.31.4-1.3-1.5-1.5-0.40.31.0
Intermittent access day 15 total locomotion3.94.26.3-2.42.4-2.52.5-2.1-2.52.52.32.3-2.3-1.1-1.6-1.11.10.5
Intermittent access total locomotion6.37.210.5-3.23.2-3.23.2-2.4-3.23.22.83.0-2.7-2.2-2.5-1.41.41.2
Intermittent access standard deviation0.80.91.8-1.31.3-1.31.3-0.8-0.90.90.70.9-0.7-0.9-0.9-0.60.40.6
Left kidney weight0.30.71.41.0-1.00.9-0.91.10.6-0.6-1.2-0.61.2-0.20.51.0-0.9-0.2
Right kidney weight0.00.10.20.1-0.1-0.10.10.2-0.20.2-0.40.20.4-0.40.10.4-0.2-0.1
Cocaine induced anxiety0.00.00.1-0.10.1-0.20.2-0.10.1-0.10.1-0.2-0.10.20.1-0.1-0.1-0.0
Post-drug Anxiety0.50.61.50.6-0.60.6-0.60.91.2-1.2-0.8-1.10.8-0.10.00.3-0.70.7
Baseline Anxiety1.31.43.01.2-1.21.2-1.21.71.4-1.4-1.4-1.51.4-0.7-0.10.3-0.51.0
Tail length1.54.67.7-2.82.8-2.82.8-2.2-2.52.52.32.5-2.3-1.0-1.6-0.70.70.4
Length with tail0.82.84.6-2.02.0-2.12.1-2.1-2.02.01.92.1-1.9-0.2-1.10.2-0.00.1
Length without tail0.10.20.40.6-0.60.5-0.5-0.10.3-0.3-0.3-0.10.30.60.40.20.0-0.3
Times rat made contact with spout0.50.61.0-0.80.8-0.80.8-1.0-1.00.90.70.6-0.60.40.3-0.60.7-1.0
Lifetime Intake2.42.74.4-1.91.9-1.91.9-1.5-2.12.11.82.0-1.8-1.3-1.50.10.00.6
Liver weight, left0.20.30.6-0.60.6-0.60.6-0.8-0.20.20.6-0.2-0.60.80.4-0.40.2-0.5
Liver weight, right0.10.20.60.4-0.40.4-0.40.60.5-0.5-0.4-0.80.40.10.2-0.50.30.0
Locomotor activity0.91.53.0-1.51.5-1.61.6-1.2-1.71.71.11.4-1.0-0.2-0.10.2-0.1-0.8
Locomotor testing distance0.50.91.7-1.11.1-1.31.3-1.0-1.31.30.81.1-0.70.10.40.1-0.0-1.0
Locomotor testing rearing0.91.47.0-0.60.6-0.70.7-0.9-1.00.90.30.6-0.21.61.8-1.41.4-2.6
Locomotion in novel chamber0.70.81.51.2-1.21.1-1.10.61.1-1.1-0.8-1.10.80.90.50.6-0.6-0.3
Locomotion in novel chamber post-restriction1.01.22.9-0.90.9-1.11.1-1.2-1.21.21.51.1-1.5-0.4-1.7-0.10.20.6
Fecal boli incidents, locomotor time 10.40.51.40.7-0.70.8-0.80.40.8-0.8-0.5-0.80.50.0-0.21.0-1.20.1
Change in fecal boli incidents, locomotor task0.70.72.2-0.80.8-0.80.8-0.5-0.70.70.91.0-0.9-0.9-0.80.2-0.21.5
Time >=10cm from walls, locomotor time 11.31.32.31.2-1.21.2-1.20.61.1-1.1-1.0-0.71.01.51.41.2-1.2-1.4
Bouts of movement, locomotor time 10.60.61.90.4-0.40.3-0.31.00.3-0.3-0.7-0.40.7-1.1-0.6-1.41.40.9
Total resting periods, locomotor time 10.60.61.80.4-0.40.4-0.40.90.4-0.4-0.7-0.50.7-1.0-0.6-1.31.31.1
Rest time, locomotor task time 11.11.22.11.4-1.41.4-1.40.81.3-1.3-1.1-1.41.10.81.0-0.70.70.1
Distance moved, locomotor task time 10.40.40.8-0.80.8-0.80.8-0.0-0.70.70.40.7-0.4-0.9-0.7-0.40.40.3
Vertical activity count, locomotor time 10.30.30.6-0.60.6-0.70.7-0.1-0.60.70.40.8-0.4-0.6-0.70.1-0.00.0
Time >=10cm from walls, locomotor time 22.12.35.01.4-1.41.4-1.41.01.0-1.0-1.4-1.31.51.72.2-1.61.9-1.7
Bouts of movement, locomotor time 21.11.23.01.0-1.01.0-1.01.70.8-0.8-1.4-0.81.5-1.3-0.4-1.11.20.7
Total resting periods, locomotor time 21.21.33.21.2-1.21.2-1.21.81.1-1.0-1.6-1.01.6-1.0-0.2-0.60.70.6
Rest time, locomotor task time 25.36.19.73.0-3.02.9-2.92.33.1-3.1-2.4-2.82.40.91.22.3-2.40.6
Distance moved, locomotor task time 21.21.37.9-0.70.7-0.70.7-0.1-0.80.80.00.40.10.20.9-2.72.8-0.9
Vertical activity count, locomotor time 22.83.17.4-1.91.9-1.91.9-1.3-2.22.21.31.8-1.2-0.4-0.2-2.42.7-0.8
Light reinforcement 10.61.16.50.1-0.10.1-0.11.4-0.20.3-0.30.00.3-2.5-1.8-0.60.72.0
Light reinforcement 20.81.05.00.4-0.40.4-0.41.40.6-0.6-0.6-0.20.5-1.9-1.60.2-0.32.2
Bone: marrow area11.224.250.3-5.95.9-5.95.9-7.1-5.65.56.05.1-5.91.6-0.6-1.71.8-2.4
Bone: maximum diameter3.66.612.8-3.13.1-3.13.1-3.6-2.92.93.32.6-3.30.0-1.20.2-0.1-0.2
Bone: maximum force2.44.15.8-2.42.4-2.42.4-2.0-2.42.42.32.3-2.3-1.5-2.0-0.40.51.1
Bone: maximum moment2.54.46.2-2.52.5-2.52.5-2.1-2.52.52.42.3-2.4-1.5-1.9-0.40.61.0
Mean time between licks in bursts0.20.31.1-0.50.5-0.50.50.30.0-0.0-0.30.20.3-1.0-0.8-0.50.41.0
Mean num. licks in bursts0.10.10.6-0.00.0-0.00.0-0.0-0.40.40.2-0.2-0.2-0.7-0.6-0.30.60.6
Cd content in liver1.01.12.41.3-1.31.3-1.30.91.6-1.6-1.1-1.31.00.60.60.2-0.40.2
Co content in liver0.50.60.90.8-0.80.8-0.80.50.9-0.9-0.8-0.60.80.90.70.6-0.6-0.5
Cu content in liver0.10.10.3-0.30.3-0.30.3-0.5-0.40.40.60.5-0.6-0.1-0.3-0.10.10.1
Fe content in liver0.10.10.30.1-0.10.1-0.1-0.3-0.20.20.20.4-0.20.50.40.5-0.5-0.6
K content in liver0.30.30.9-0.10.1-0.10.1-0.5-0.20.30.80.4-0.80.0-0.60.9-0.90.4
Mg content in liver0.20.20.8-0.00.0-0.00.0-0.4-0.30.30.80.2-0.9-0.2-0.7-0.10.10.6
Mn content in liver0.50.61.5-0.50.5-0.50.5-0.8-0.50.51.20.3-1.2-0.3-0.81.0-1.20.8
Na content in liver0.50.63.20.6-0.60.6-0.60.30.5-0.5-0.1-0.20.00.0-0.11.8-1.80.4
Rb content in liver0.20.31.00.4-0.40.4-0.4-0.20.5-0.50.1-0.4-0.10.90.50.9-1.0-0.3
Se content in liver2.83.47.02.1-2.12.1-2.11.62.0-2.0-1.6-1.91.60.60.62.6-2.60.2
Sr content in liver0.10.10.1-0.30.3-0.30.30.2-0.00.0-0.20.00.2-0.3-0.20.3-0.30.2
Zn content in liver1.01.14.21.0-1.01.0-1.00.41.0-1.0-0.5-0.60.40.90.52.0-2.0-0.3
Bone: minimum diameter8.415.724.0-4.84.8-4.84.8-4.9-4.84.84.74.4-4.7-1.0-2.4-0.91.20.3
Time in familiar zone, hab. session 11.21.11.6-1.31.3-1.31.3-1.2-1.21.11.21.2-1.2-0.3-0.8-0.60.70.3
Time in novel zone, hab. session 10.40.40.80.7-0.70.7-0.70.90.7-0.6-0.8-0.70.80.00.6-0.1-0.0-0.3
Total zone transitions, hab. session 10.20.31.6-0.60.6-0.60.6-0.0-0.40.4-0.0-0.10.1-0.30.3-1.31.2-0.2
Total locomotion distance, hab. session 10.71.02.1-1.21.2-1.21.2-0.6-1.11.20.80.6-0.7-0.7-0.2-1.51.4-0.1
Locomotion velocity, hab. session 10.50.71.8-1.01.0-1.01.0-0.6-1.01.00.70.6-0.7-0.4-0.1-1.31.3-0.2
Time in familiar zone, hab. session 20.90.92.4-1.01.0-1.01.0-1.3-1.11.01.01.5-0.90.80.3-0.20.2-1.1
Time in novel zone, hab. session 20.40.41.30.6-0.60.6-0.60.80.6-0.6-0.3-1.00.3-0.8-0.5-0.1-0.01.1
Total zone transitions, hab. session 20.30.41.50.2-0.20.1-0.10.60.2-0.2-0.8-0.40.80.21.0-1.21.1-0.7
Total locomotion distance, hab. session 20.50.73.3-0.70.7-0.80.80.1-0.70.70.20.3-0.2-0.9-0.3-1.81.80.3
Locomotion velocity, hab. session 20.40.63.1-0.50.5-0.50.50.3-0.40.40.00.10.0-0.9-0.2-1.81.70.3
Novel to familiar place preference ratio1.51.62.5-1.51.5-1.51.5-1.4-1.41.41.41.6-1.4-0.7-1.1-0.40.40.6
Novelty place preference0.90.91.5-1.21.2-1.21.2-1.2-1.11.11.11.2-1.1-0.4-0.6-0.40.30.3
Time in novel zone, NPP test0.80.81.5-1.11.1-1.11.1-1.1-1.11.11.11.2-1.0-0.2-0.5-0.30.20.0
Total zone transitions, NPP test0.10.10.40.3-0.30.3-0.30.60.2-0.1-0.5-0.50.5-0.30.4-0.10.1-0.1
Total locomotion distance, NPP test0.50.71.8-0.70.7-0.70.7-0.5-1.11.10.80.8-0.7-0.4-0.1-1.21.3-0.3
Locomotion velocity, NPP test0.20.31.0-0.30.3-0.30.30.2-0.60.70.30.4-0.3-1.0-0.5-0.81.00.5
Intraocular pressure0.10.10.5-0.20.2-0.20.20.20.0-0.0-0.20.20.2-0.30.00.7-0.60.0
Delta distance traveled before/after self-admin0.10.10.30.3-0.30.2-0.20.40.0-0.0-0.4-0.10.40.10.5-0.10.3-0.4
Delta ambulatory time before/after self-admin0.40.50.9-0.70.7-0.80.8-0.6-0.90.90.70.9-0.7-0.3-0.2-0.40.6-0.1
Parametrial fat weight1.42.73.9-1.81.8-1.81.8-1.3-1.41.41.91.2-2.0-1.3-1.9-1.71.51.7
Pavlov. Cond. lever latency0.20.31.30.4-0.40.4-0.40.40.7-0.6-0.1-1.10.1-0.3-0.6-0.50.31.0
Pavlov. Cond. magazine entry latency1.31.74.4-1.41.4-1.41.4-1.4-1.71.71.42.1-1.4-0.1-0.70.9-0.7-0.4
Pavlov. Cond. change in total contacts0.80.92.6-0.90.9-0.90.9-1.0-1.31.30.81.6-0.70.50.30.6-0.3-1.3
Pavlov. Cond. index score0.70.93.2-0.90.9-0.90.9-1.0-1.31.30.91.8-0.90.0-0.11.0-0.7-0.7
Pavlov. Cond. latency score0.50.62.4-0.60.6-0.60.6-0.7-1.01.00.51.5-0.50.10.11.0-0.8-0.8
Pavlov. Cond. lever contacts0.20.21.50.1-0.10.1-0.10.1-0.20.2-0.50.70.50.41.00.10.0-1.2
Pavlov. Cond. magazine entry number1.11.33.21.1-1.11.1-1.11.31.4-1.4-1.3-1.81.30.00.7-1.20.90.2
Pavlov. Cond. intertrial magazine entries1.62.03.1-1.81.8-1.81.8-1.2-1.41.51.41.4-1.4-1.2-1.60.3-0.41.0
Pavlov. Cond. lever-magazine prob. diff.0.60.72.4-0.70.7-0.70.7-0.9-1.11.10.71.6-0.70.1-0.11.0-0.8-0.7
Pavlov. Cond. response bias0.70.82.3-0.80.8-0.80.8-1.1-1.21.20.91.5-0.90.2-0.00.9-0.7-0.7
Pavlov. Cond. lever latency0.71.02.10.8-0.80.8-0.81.31.1-1.1-1.1-1.41.1-0.5-0.1-1.21.00.9
Pavlov. Cond. magazine entry latency2.12.44.31.9-1.91.9-1.91.31.5-1.5-1.5-1.11.50.91.02.1-1.8-0.6
Pavlov. Cond. change in total contacts0.50.72.2-0.10.1-0.10.1-0.9-0.50.50.61.0-0.61.10.51.5-1.2-1.2
Pavlov. Cond. index score0.50.63.30.1-0.10.1-0.1-0.6-0.30.30.20.7-0.20.90.61.8-1.6-1.1
Pavlov. Cond. latency score0.60.84.10.3-0.30.3-0.3-0.5-0.10.00.00.5-0.01.10.82.0-1.8-1.3
Pavlov. Cond. lever contacts0.60.82.4-0.70.7-0.70.7-1.1-1.21.21.11.6-1.10.0-0.20.9-0.6-0.6
Pavlov. Cond. magazine entry number2.63.25.5-2.12.1-2.12.1-1.5-1.81.81.81.3-1.8-1.1-1.3-2.32.10.9
Pavlov. Cond. intertrial magazine entries7.19.313.0-3.63.6-3.63.6-2.7-3.43.43.32.9-3.3-1.8-2.3-3.02.81.1
Pavlov. Cond. lever-magazine prob. diff.0.50.73.80.2-0.20.2-0.2-0.5-0.10.10.10.6-0.10.90.62.0-1.7-1.1
Pavlov. Cond. response bias0.30.51.5-0.30.3-0.30.3-0.7-0.80.70.71.2-0.70.2-0.11.2-1.0-0.6
Time in closed arm before self-admin0.30.41.0-0.40.4-0.50.5-0.3-0.90.90.41.0-0.30.00.2-0.61.0-0.8
Time in closed arm after self-admin0.40.52.0-0.10.1-0.20.2-0.7-0.50.50.30.6-0.21.40.9-0.50.6-1.4
Time in open arm before self-admin1.11.22.41.2-1.21.1-1.11.11.4-1.4-1.6-1.21.60.60.70.6-0.8-0.5
Time in open arm after self-admin1.61.73.41.4-1.41.4-1.41.31.4-1.4-1.2-1.21.2-0.4-0.21.9-1.80.9
Bone: periosteal estimation8.217.029.5-5.05.0-5.05.0-5.4-5.04.95.04.4-5.0-0.1-1.6-1.11.3-0.8
Bone: periosteal perimeter2.84.79.7-2.72.7-2.72.7-3.1-2.52.52.62.3-2.60.3-0.70.4-0.2-0.6
Bone: post-yield work1.11.52.9-1.51.5-1.51.5-1.7-1.51.51.41.1-1.4-0.2-0.7-0.40.40.2
Progressive ratio test 1 active lever presses2.72.85.3-2.02.0-2.02.0-1.5-2.32.31.82.0-1.8-1.2-1.2-0.40.70.3
Progressive ratio test 1 breakpoint3.23.36.2-2.12.1-2.12.1-1.6-2.52.51.92.1-1.9-1.5-1.4-0.60.90.5
Progressive ratio test 1 inactive lever presses2.52.85.1-2.12.1-2.02.0-1.6-2.32.31.82.0-1.7-0.9-1.1-0.20.4-0.0
Progressive ratio test 2 active lever presses1.92.13.4-1.71.7-1.71.7-1.6-1.81.81.91.5-1.9-0.6-1.30.3-0.30.4
Progressive ratio test 2 breakpoint2.52.84.6-1.91.9-2.02.0-2.0-2.12.12.11.8-2.1-0.5-1.2-0.10.10.2
Progressive ratio test 2 inactive lever presses2.83.34.9-1.91.9-2.12.1-1.8-2.02.02.21.9-2.2-1.5-2.10.2-0.21.3
Incentive Sensitization - Responses0.40.41.0-0.70.7-0.70.7-1.0-0.50.51.00.2-1.00.5-0.20.5-0.7-0.2
Incentive Sensitization - Breakpoint0.40.41.1-0.60.6-0.70.7-1.0-0.40.41.00.2-1.00.7-0.10.6-0.8-0.3
Sum of active levers in priming session hrs 5-60.10.10.4-0.10.1-0.20.2-0.1-0.00.0-0.10.10.10.50.5-0.60.6-0.5
Progressive ratio0.80.92.21.0-1.01.0-1.00.61.2-1.2-0.7-0.90.60.1-0.11.4-1.50.5
Food seeking constrained by brief footshock2.43.05.3-2.22.2-2.12.1-2.3-1.81.81.81.5-1.81.10.6-1.00.9-1.7
Seeking ratio, punishment vs. effort2.22.73.8-1.91.9-1.91.9-1.7-2.01.91.51.5-1.50.50.4-1.81.8-1.3
Retroperitoneal fat weight1.34.216.5-2.02.0-2.02.0-0.4-1.91.90.61.6-0.6-1.6-1.1-4.14.10.4
Reaction time number correct0.50.71.51.2-1.21.1-1.10.60.9-0.9-0.5-0.80.40.00.01.0-0.90.6
Reaction time mean minus median0.10.20.60.2-0.20.1-0.10.30.3-0.3-0.2-0.50.2-0.5-0.4-0.70.70.8
Reaction time mean minus median AUC0.20.21.2-0.10.1-0.20.2-0.2-0.00.10.4-0.1-0.4-0.7-0.80.2-0.21.1
Reaction time num false alarms0.81.12.2-1.11.1-1.11.1-1.5-1.41.31.10.8-1.10.60.10.8-0.5-0.9
Reaction time num false alarms AUC1.41.93.6-1.61.6-1.61.6-1.9-1.81.81.71.4-1.60.3-0.40.5-0.1-0.6
Reaction time trials correct on left0.50.71.51.2-1.21.1-1.10.60.9-0.9-0.5-0.80.40.00.01.0-0.90.6
Reaction time trials on left0.40.61.31.1-1.11.0-1.00.50.8-0.8-0.4-0.70.3-0.0-0.11.0-0.90.6
Reaction time mean0.00.10.3-0.00.0-0.10.1-0.4-0.00.00.4-0.0-0.40.5-0.10.3-0.3-0.1
Reaction time mean AUC0.00.10.5-0.00.0-0.10.1-0.4-0.00.00.3-0.1-0.30.70.10.00.0-0.4
Median of all reaction times0.10.20.6-0.30.3-0.30.3-0.7-0.30.30.70.2-0.70.8-0.10.4-0.3-0.4
Reaction time omissions0.71.01.5-1.01.0-1.21.2-0.7-0.91.01.01.1-1.0-0.8-1.2-0.70.80.9
Reaction time false alarm rate1.31.83.1-1.71.7-1.71.7-1.8-1.71.71.31.2-1.30.70.2-0.10.3-1.3
Reaction time premature initiation rate0.40.50.8-0.90.9-0.90.9-0.2-0.80.80.40.8-0.3-0.8-0.8-0.40.50.4
Reaction time premature initiations0.10.20.7-0.20.2-0.30.30.1-0.40.40.20.4-0.2-0.8-0.80.1-0.00.7
Std. dev. reaction times0.10.10.4-0.30.3-0.40.4-0.6-0.20.20.50.1-0.50.3-0.2-0.50.50.0
Reaction time trials completed0.40.61.31.1-1.11.0-1.00.50.8-0.8-0.4-0.70.3-0.0-0.11.0-0.90.6
Reaction time trials AUC0.40.51.11.1-1.11.0-1.00.50.8-0.8-0.3-0.80.3-0.0-0.10.8-0.70.6
Run reversals in cocaine runway, females3.13.07.51.3-1.31.4-1.42.41.3-1.3-2.2-1.42.2-1.3-0.2-2.52.71.2
Run reversals in cocaine runway, males0.20.20.40.6-0.60.5-0.50.30.6-0.6-0.2-0.60.2-0.00.30.3-0.40.4
Latency to leave start box in cocaine runway1.21.33.51.0-1.01.0-1.00.91.0-1.0-1.2-1.31.21.31.9-0.20.2-1.6
Latency to leave start box in cocaine runway, F2.73.04.91.8-1.81.8-1.81.41.7-1.7-1.9-1.92.01.62.21.1-1.1-1.7
Latency to leave start box in cocaine runway, M0.60.63.9-0.30.3-0.30.3-0.1-0.30.30.20.1-0.10.10.4-2.01.9-0.3
Std. dev. time between licks in bursts0.40.51.60.2-0.20.2-0.21.10.3-0.3-0.6-0.20.6-1.3-0.8-0.70.71.2
Total sessions with >9 infusions0.60.72.4-0.40.4-0.40.40.3-0.30.30.10.2-0.2-1.5-1.01.5-1.51.1
Short access day 1 total inactive lever presses0.10.10.80.2-0.20.2-0.2-0.1-0.20.20.2-0.0-0.2-0.4-0.30.8-0.90.3
Short access day 10 total inactive lever presses0.50.51.4-0.90.9-0.90.9-0.5-0.60.60.40.3-0.4-0.3-0.3-1.21.10.2
Short access day 1 total infusions0.40.41.4-0.50.5-0.30.30.2-0.30.30.30.1-0.3-1.2-0.81.0-1.20.8
Short access day 10 total infusions4.14.67.6-2.32.3-2.22.2-1.5-2.72.82.12.4-2.1-2.4-2.3-1.21.51.2
Short access total infusions1.71.93.7-1.61.6-1.51.5-1.3-1.91.91.61.6-1.6-1.1-1.10.2-0.10.2
Short access day 1 locomotion2.52.78.4-1.41.4-1.41.4-0.5-1.81.81.41.4-1.4-2.9-2.5-0.00.22.2
Short access day 10 total locomotion5.86.511.5-3.43.4-3.43.4-2.1-2.72.72.32.4-2.3-2.0-2.1-2.01.61.2
Short access total locomotion3.53.76.8-2.22.2-2.12.1-1.0-2.32.31.61.9-1.6-2.6-2.2-1.01.11.6
One hour access (0.3 mA shock)2.12.44.0-1.91.9-2.02.0-1.9-1.81.81.71.9-1.70.2-0.30.6-0.7-0.8
Compulsive drug intake0.50.53.00.0-0.0-0.10.1-0.6-0.00.00.20.4-0.20.90.41.6-1.7-0.8
One hour access (shock baseline)0.80.91.6-1.11.1-1.11.1-0.8-1.21.21.01.2-1.0-0.7-0.7-0.50.70.3
Social response proportion0.40.42.1-0.30.3-0.40.4-0.5-0.80.80.71.5-0.7-0.1-0.60.5-0.2-0.1
Social responses1.41.95.3-1.21.2-1.41.4-1.3-2.12.11.42.3-1.4-0.6-0.90.20.2-0.3
Social time0.20.31.30.5-0.50.3-0.3-0.20.3-0.3-0.20.20.21.10.80.7-0.5-1.0
Soleus weight0.10.41.00.4-0.40.4-0.40.40.6-0.7-0.8-0.60.80.40.80.9-1.0-0.4
Bone: stiffness1.42.34.1-1.51.5-1.51.5-1.5-1.91.91.82.0-1.8-1.1-1.6-0.10.30.9
Tibialis anterior weight0.31.25.6-0.30.3-0.30.30.8-0.20.2-0.6-0.20.7-1.7-0.6-2.42.41.0
Time to tail flick, vehicle, before self-admin0.50.51.90.5-0.50.6-0.6-0.40.7-0.7-0.1-0.40.11.40.51.3-1.2-0.4
Time to tail flick, vehicle, after self-admin0.80.92.3-0.60.6-0.70.7-0.8-0.50.51.00.9-1.1-0.8-1.51.0-1.01.5
Time to tail flick, test, before self-admin0.50.51.1-0.80.8-0.90.9-1.1-0.50.50.70.8-0.70.4-0.1-0.80.8-0.3
Time to tail flick, test, after self-admin1.11.22.6-1.11.1-1.01.0-1.4-1.31.31.41.6-1.4-0.4-0.90.00.10.2
Delta time to tail flick, vehicle, before/after SA3.53.45.0-2.22.2-2.22.2-1.5-1.91.92.11.9-2.1-1.7-2.0-1.00.81.2
Delta time to tail flick, test, before/after SA0.20.20.7-0.10.10.1-0.1-0.6-0.40.40.70.6-0.70.1-0.40.9-0.70.1
Tibia length0.10.42.9-0.10.1-0.10.1-0.0-0.10.1-0.10.30.1-0.3-0.51.7-1.60.4
Ambulatory time before self-admin1.41.52.71.4-1.41.2-1.20.61.3-1.3-0.9-1.20.91.31.11.5-1.7-0.9
Ambulatory time after self-admin0.30.41.30.6-0.60.3-0.3-0.10.3-0.3-0.2-0.20.21.10.90.7-0.7-1.1
Bone: tissue strength1.31.21.81.3-1.31.4-1.41.01.3-1.3-1.0-1.31.00.60.81.1-1.1-0.2
Total heroin consumption0.30.31.1-0.20.2-0.40.4-0.8-0.50.50.60.7-0.60.90.30.2-0.3-1.0
Bone: trabecular number0.61.02.0-1.21.2-1.21.2-1.1-0.80.91.40.7-1.4-0.4-0.80.3-0.30.7
Bone: trabecular spacing0.40.51.00.9-0.90.8-0.80.60.5-0.5-0.8-0.40.90.70.9-0.20.3-1.0
Bone: trabecular thickness1.61.93.6-1.61.6-1.51.5-0.9-1.31.31.31.2-1.4-1.7-1.9-0.00.11.6
Bone: trabecular tissue density0.71.04.20.5-0.50.6-0.61.30.4-0.4-0.50.00.5-1.8-1.60.7-0.62.0
Water consumed over 24 hours0.40.41.4-0.60.6-0.60.60.3-0.60.60.20.2-0.1-1.2-0.7-1.01.00.7
Number of responses in last shaping day0.10.10.30.1-0.10.1-0.10.0-0.20.2-0.0-0.30.0-0.5-0.4-0.10.30.5