Hub : Genes

Cacng4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Cacng4 0.08 0.04 3.9e-13 0.09 0.09 0.08 0.09 5.4e-13 2.7e-13 1.1e-11 1.6e-13
2 PL mRNA stability Cacng4 0.03 0.03 1.3e-03 0.03 0.01 0 0.02 3.8e-04 1.0e-02 3.1e-01 3.4e-03
3 NAcc gene expression Cacng4 0.16 0.06 0.0e+00 0.21 0.22 0.22 0.22 1.9e-30 4.4e-32 1.4e-32 4.5e-33
4 BLA gene expression Cacng4 0.13 0.07 3.0e-05 0.07 0.03 0.01 0.05 1.6e-04 1.1e-02 6.9e-02 1.2e-03
5 Liver gene expression Cacng4 0.1 0.05 1.1e-16 0.11 0.13 0.12 0.12 3.3e-12 6.9e-14 2.3e-13 2.1e-13
6 Brain gene expression Cacng4 0.22 0.08 5.6e-17 0.13 0.17 0.18 0.19 5.7e-12 3.0e-15 1.9e-16 2.4e-17
7 Adipose gene expression Cacng4 0.11 0.05 3.0e-07 0.05 0.05 0.04 0.05 1.6e-06 2.8e-06 8.7e-06 7.3e-06
8 pVTA gene expression Cacng4 0.15 0.07 1.6e-05 0.01 0.06 0.06 0.04 4.1e-02 2.6e-05 2.9e-05 2.1e-04
9 OFC gene expression Cacng4 0.34 0.14 6.4e-04 0 0.04 0.02 0.06 2.4e-01 4.8e-02 1.2e-01 1.3e-02
10 PL gene expression Cacng4 0.09 0.04 8.2e-06 0.01 0.04 0.03 0.03 6.5e-02 1.6e-05 1.7e-04 5.5e-04
11 IC gene expression Cacng4 0.25 0.1 3.6e-05 0.09 0.1 0.03 0.06 1.2e-04 8.5e-05 1.7e-02 2.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.20.41.1-0.60.60.6-0.50.90.9-1.0-0.1-0.60.0-0.4
Area under the delay curve0.40.72.60.8-0.8-0.80.6-0.10.5-0.5-0.7-1.6-0.6-1.2
BMI with tail1.86.217.8-0.60.40.2-1.4-0.3-1.74.1-3.6-1.8-4.2-3.4
BMI without tail1.47.423.5-1.61.31.0-2.10.4-1.24.0-3.8-1.6-4.8-3.7
Body weight1.46.314.7-2.72.52.3-3.22.10.81.8-2.5-1.3-3.8-3.1
Weight adjusted by age0.51.53.41.8-1.8-1.80.9-1.5-0.81.3-0.1-1.10.5-0.2
Bone surface2.95.78.9-2.82.82.8-2.72.93.0-2.61.71.31.41.1
Bone volume1.73.36.6-2.12.12.1-2.12.42.6-2.30.80.20.60.1
Breakpoint value in progressive ratio session0.81.42.91.3-1.4-1.40.9-1.7-1.41.60.20.80.50.7
Number of licking bursts0.10.20.4-0.20.20.3-0.20.20.1-0.70.60.60.40.7
Context. condit. distance diff. score0.10.10.20.4-0.5-0.40.1-0.10.00.4-0.4-0.4-0.3-0.4
Locomotion velocity, session 10.20.20.6-0.50.50.5-0.60.40.4-0.20.40.80.30.4
Locomotion distance, session 10.10.10.4-0.10.00.0-0.6-0.10.30.20.20.40.20.2
Locomotion velocity, session 22.02.47.4-1.21.11.1-1.20.30.80.12.22.71.62.4
Locomotion distance, session 20.40.62.1-0.40.30.3-0.0-0.40.00.61.21.50.61.3
Locomotion velocity, session 31.21.43.11.3-1.5-1.41.5-1.8-1.01.4-0.1-0.6-0.10.2
Locomotion distance, session 30.30.30.80.5-0.5-0.40.6-0.30.4-0.40.8-0.40.90.7
Stereotopy head waving bouts, day 31.41.73.61.9-1.9-1.91.2-1.5-0.90.8-1.1-1.0-0.3-0.9
Stereotopy head waving duration, day 31.21.43.21.8-1.8-1.81.4-1.4-0.60.4-0.7-0.9-0.2-0.8
Locomotion velocity, session 70.30.41.00.7-0.7-0.70.2-0.7-1.00.9-0.50.30.10.1
Locomotion distance, session 70.00.00.1-0.20.20.20.10.20.0-0.2-0.0-0.1-0.1-0.0
Stereotopy head waving bouts, day 71.31.53.51.5-1.6-1.61.4-1.9-0.81.10.60.10.70.9
Stereotopy head waving duration, day 71.92.44.91.8-1.9-1.91.9-2.2-1.00.91.10.31.31.5
Locomotion velocity, session 80.40.51.3-0.40.40.4-0.70.40.5-0.30.81.01.11.0
Locomotion distance, session 80.20.31.1-0.50.40.4-0.50.20.30.20.81.00.50.9
Degree of sensitization distance0.30.30.6-0.60.60.6-0.70.70.1-0.1-0.50.4-0.6-0.6
Degree of sensitization stereotypy1.31.43.41.0-1.1-1.21.2-1.9-0.91.41.00.70.71.4
Conditioned locomotion0.10.10.2-0.10.10.1-0.40.1-0.40.1-0.4-0.2-0.2-0.3
Cocaine response after cond. corrected0.20.20.80.5-0.4-0.40.6-0.10.5-0.90.5-0.30.40.4
Cocaine response after cond. not corrected0.81.23.60.5-0.4-0.40.4-0.30.8-1.01.81.01.71.9
Cocaine response before conditioning1.01.33.70.1-0.1-0.2-0.2-0.30.8-0.31.81.81.71.9
Saline control response1.01.34.2-0.90.80.6-0.9-0.1-1.02.1-1.10.9-1.9-1.0
Bone: connectivity density0.50.71.4-1.01.01.0-1.01.21.1-1.00.40.10.40.1
Bone: cortical apparent density5.07.912.52.8-2.8-2.92.5-2.3-2.52.1-3.4-3.5-2.6-3.1
Bone: cortical area0.50.91.8-1.41.21.1-1.20.80.60.4-0.5-0.3-1.2-0.8
Bone: cortical porosity5.25.610.9-2.62.52.5-2.51.81.9-1.22.73.31.82.5
Bone: cortical porosity3.13.45.1-2.32.22.1-2.21.61.9-0.92.02.21.01.6
Bone: cortical thickness6.09.915.52.7-2.9-3.12.9-3.4-3.43.9-3.2-2.7-3.4-2.8
Bone: cortical thickness2.42.96.71.0-1.1-1.31.2-1.7-2.42.6-2.0-0.1-2.2-1.6
Bone: cortical tissue density4.97.712.22.7-2.8-2.92.5-2.3-2.52.1-3.4-3.5-2.6-3.1
Condit. Reinf. active minus inactive responses3.84.37.7-2.12.02.1-2.42.02.8-1.72.22.41.11.5
Condit. Reinf. active-inactive response ratio1.71.83.1-1.01.11.1-1.21.21.8-1.51.51.61.21.1
Condit. Reinf. active responses3.74.78.4-2.32.22.2-2.82.22.9-1.52.12.41.11.4
Condit. Reinf. inactive responses0.91.13.1-1.21.11.1-1.81.21.5-0.30.70.80.20.3
Incentive salience index mean2.22.85.1-1.81.71.7-2.21.52.0-0.91.82.30.91.4
Condit. Reinf. lever presses0.30.41.7-0.40.30.3-0.7-0.2-0.20.80.71.30.30.8
Condit. Reinf. active minus inactive responses4.46.810.0-3.23.03.0-2.52.63.0-2.12.82.31.32.1
Condit. Reinf. active-inactive response ratio2.74.26.1-2.32.22.3-1.51.92.0-2.02.52.21.42.1
Condit. Reinf. active responses5.57.913.2-3.63.43.4-3.23.13.1-2.12.52.41.01.9
Condit. Reinf. inactive responses1.42.05.8-2.11.91.7-2.41.71.5-0.20.40.8-0.30.0
Condit. Reinf. lever presses3.14.510.1-3.23.02.9-2.52.01.7-0.51.82.0-0.01.3
Condit. Reinf. lever reinforcers received5.37.412.8-3.63.43.4-3.13.02.9-2.02.42.30.91.8
Conditioned reinforcement - actives0.20.61.8-1.31.31.4-0.20.60.5-0.60.20.4-0.70.3
Conditioned reinforcement - inactives0.20.51.5-1.00.90.9-1.20.70.8-0.0-0.10.3-0.4-0.2
Conditioned locomotion1.21.83.9-2.01.91.8-1.41.61.0-0.3-0.60.0-1.3-0.8
Patch foraging indifference point 0 sec1.95.411.0-3.33.13.1-3.33.02.1-0.7-0.30.4-1.9-1.2
Patch foraging indifference point AUC0.10.30.8-0.90.80.6-0.80.70.3-0.5-0.30.1-0.5-0.1
Delay disc. indifference point, 0s delay0.60.71.41.2-1.1-1.11.2-0.9-0.50.0-0.2-1.10.2-0.3
Delay disc. indifference point, 16s delay0.50.62.10.2-0.3-0.30.40.10.3-0.2-0.9-1.5-1.2-1.4
Delay disc. indifference point, 2s delay0.70.82.30.0-0.0-0.0-0.71.01.5-1.5-0.4-1.1-0.0-1.0
Delay disc. indifference point, 24s delay0.91.54.8-0.60.40.4-0.70.80.5-0.1-1.7-1.4-2.1-2.2
Delay disc. indifference point, 4s delay0.60.61.61.0-1.0-0.91.3-0.80.0-0.30.7-0.50.90.6
Delay disc. indifference point, 8s delay1.01.74.01.6-1.6-1.61.1-0.8-0.40.2-1.3-2.0-0.8-1.7
Indifference point function ln k0.10.31.00.7-0.8-0.70.2-0.6-0.21.0-0.0-0.20.0-0.2
Indifference point function log k0.10.31.00.7-0.8-0.70.2-0.6-0.21.0-0.0-0.20.0-0.2
Patch foraging total patch changes 0 sec1.85.210.5-3.23.13.1-3.12.92.0-0.8-0.20.5-1.8-1.1
Patch foraging total patch changes 12 sec3.44.69.0-2.82.82.9-3.02.92.2-1.60.10.7-0.9-0.5
Patch foraging total patch changes 18 sec0.61.33.6-1.71.51.4-1.91.20.70.1-0.20.9-1.0-0.3
Patch foraging total patch changes 24 sec0.62.24.9-2.01.91.8-2.21.81.4-0.5-0.50.3-1.3-0.8
Patch foraging total patch changes 6 sec2.74.69.6-3.13.02.8-3.12.72.0-1.20.30.7-1.2-0.4
Patch foraging time to switch 0 sec0.10.40.90.9-0.8-0.61.0-0.8-0.80.0-0.2-0.2-0.2-0.1
Patch foraging water rate 0 sec0.62.14.6-2.01.91.8-2.21.91.4-0.1-0.50.1-1.0-0.8
Patch foraging water rate 12 sec0.10.21.0-0.0-0.0-0.20.4-0.5-0.41.0-0.3-0.3-0.6-0.3
Patch foraging water rate 18 sec0.10.20.8-0.10.0-0.1-0.50.10.20.9-0.4-0.4-0.6-0.6
Patch foraging water rate 24 sec0.10.20.70.6-0.6-0.8-0.2-0.30.40.30.3-0.00.60.1
Patch foraging water rate 6 sec0.30.41.90.4-0.4-0.70.0-0.5-0.41.4-0.7-0.3-0.7-0.8
Seeking ratio, delayed vs. immediate footshock0.40.51.30.5-0.5-0.40.5-0.3-0.40.7-1.2-0.8-1.0-1.1
Distance traveled before self-admin0.40.91.50.9-0.9-1.01.2-1.00.3-0.61.20.51.21.1
Distance traveled after self-admin0.61.13.0-0.50.50.5-0.20.11.1-0.91.71.31.31.7
Extensor digitorum longus weight1.87.311.52.6-2.4-2.52.2-2.5-3.33.4-3.3-2.9-1.8-2.4
Bone: elastic displacement0.70.91.91.2-1.3-1.41.0-1.4-1.01.1-0.0-0.10.10.4
Bone: elastic work0.60.72.0-0.1-0.0-0.2-0.6-0.2-0.71.4-1.3-0.8-1.3-1.0
Bone: endosteal estimation12.730.947.6-6.86.86.9-6.66.66.0-4.94.24.22.83.1
Bone: endosteal perimeter10.124.738.3-5.96.06.1-5.96.25.9-5.03.62.92.52.3
Epididymis fat weight0.42.06.0-0.30.30.3-0.50.2-1.21.5-2.2-1.5-2.5-2.2
Delta time in closed arm before/after self-admin0.10.10.30.6-0.5-0.5-0.0-0.00.2-0.6-0.2-0.30.5-0.1
Delta time in open arm before/after self-admin0.40.41.30.7-0.7-0.81.0-0.7-0.30.2-0.2-1.1-0.2-0.4
Diff in mean of infusions in LGA sessions1.32.45.71.4-1.4-1.61.7-1.9-2.42.3-1.1-0.4-0.9-0.5
Delay discount exponential model param0.40.52.0-0.50.50.5-0.3-0.2-0.70.70.61.40.51.1
Extinction: sum of active levers before priming0.40.61.20.7-0.8-1.00.4-0.9-0.91.1-0.9-0.9-0.3-0.5
Active lever presses in extinction session 60.50.51.1-1.00.90.8-1.10.80.4-0.3-0.20.7-0.5-0.1
Bone: final force0.81.32.8-1.51.41.3-1.71.51.3-0.7-0.10.6-0.5-0.6
Bone: final moment0.91.42.9-1.61.51.4-1.71.61.3-0.8-0.00.6-0.5-0.5
Food consumed during 24 hour testing period0.91.85.6-1.21.21.1-1.00.5-0.91.6-1.6-0.1-2.4-1.7
Glucose1.11.73.91.8-1.9-1.81.6-2.0-1.10.9-0.2-0.00.40.3
Heart weight0.30.51.50.6-0.6-0.71.2-0.8-0.60.2-0.3-1.2-0.6-0.4
Delay discount hyperbolic model param0.40.52.0-0.60.60.6-0.2-0.2-0.70.60.61.40.31.1
Intermittent access intake day 1-15 change0.10.51.1-0.80.90.9-0.20.6-0.4-0.50.80.70.71.0
Intermittent access intake escalation0.10.51.1-0.91.01.1-0.60.8-0.1-0.40.60.60.60.8
Intermittent access intake escalation 20.61.12.3-1.31.41.5-0.81.2-0.1-1.00.60.70.71.1
Intermitt. access day 1 inactive lever presses0.10.93.1-1.11.11.0-1.70.70.70.50.51.30.20.6
Intermitt. access day 15 inactive lever presses0.10.51.1-0.70.70.6-1.10.5-0.40.7-1.00.5-0.8-0.6
Intermitt. access escalation Index0.31.02.80.4-0.4-0.41.7-1.1-0.7-0.11.40.90.91.5
Intermittent access day 1 total infusions0.20.61.8-1.10.90.8-1.00.41.30.10.50.5-0.50.2
Intermittent access day 15 total infusions0.51.33.2-1.81.71.7-1.31.21.0-0.30.50.4-0.60.1
Intermittent access terminal intake (last 3 days)1.62.96.2-2.52.52.4-1.92.11.6-1.30.70.8-0.30.3
Intermittent access total infusions1.92.34.6-2.12.02.0-1.91.72.0-0.70.60.7-0.60.0
Intermittent access day 1 locomotion1.12.14.5-2.11.91.8-2.11.31.60.60.00.8-1.3-0.5
Intermittent access day 15 total locomotion1.04.08.6-2.92.82.7-2.92.41.9-0.10.21.0-1.1-0.4
Intermittent access total locomotion4.85.812.5-3.53.33.2-3.52.72.50.1-0.11.1-1.7-0.8
Intermittent access standard deviation0.10.51.1-0.90.90.9-0.91.00.7-0.9-0.10.30.1-0.1
Left kidney weight0.00.21.7-0.20.1-0.1-0.2-0.5-0.01.30.00.3-0.7-0.1
Right kidney weight0.10.41.6-0.1-0.1-0.20.2-0.5-0.21.3-0.4-0.7-1.1-0.7
Cocaine induced anxiety0.10.41.00.1-0.1-0.1-0.2-0.10.8-0.50.90.81.00.9
Post-drug Anxiety0.40.51.51.1-1.2-1.20.3-0.70.1-0.1-0.4-0.10.5-0.1
Baseline Anxiety1.32.25.31.2-1.2-1.21.2-1.0-1.70.9-2.3-1.6-1.6-1.8
Tail length0.84.59.9-3.23.12.9-3.12.71.7-0.5-0.10.7-1.3-0.5
Length with tail1.14.79.0-2.72.72.7-2.83.02.7-2.00.70.4-0.1-0.1
Length without tail0.10.41.1-0.30.40.5-0.41.00.8-1.1-0.1-0.8-0.1-0.6
Times rat made contact with spout0.91.05.1-1.21.21.1-0.60.70.3-0.10.72.30.30.8
Lifetime Intake1.51.93.8-1.91.81.7-1.91.51.8-0.20.20.5-1.0-0.3
Liver weight, left2.34.16.2-2.22.22.2-2.52.02.0-0.91.92.51.41.7
Liver weight, right0.40.73.70.3-0.4-0.50.5-1.3-0.91.90.10.5-0.60.3
Locomotor activity1.11.74.5-2.11.91.8-1.20.70.70.90.81.5-1.00.5
Locomotor testing distance0.51.33.0-1.71.51.3-1.10.30.31.10.81.7-0.60.7
Locomotor testing rearing0.62.48.6-1.61.41.1-1.60.1-0.51.81.42.90.61.8
Locomotion in novel chamber0.40.61.51.0-1.0-1.0-0.1-0.50.6-0.20.80.61.20.5
Locomotion in novel chamber post-restriction0.51.55.6-0.50.60.7-1.81.72.4-1.80.4-0.00.7-0.5
Fecal boli incidents, locomotor time 10.10.20.50.7-0.6-0.50.5-0.00.3-0.70.2-0.10.6-0.1
Change in fecal boli incidents, locomotor task0.50.51.5-0.50.60.6-0.10.90.3-1.2-0.7-1.2-0.6-0.6
Time >=10cm from walls, locomotor time 10.81.02.01.0-0.9-1.01.0-1.0-0.20.11.30.61.41.4
Bouts of movement, locomotor time 10.81.02.20.6-0.6-0.60.1-0.5-1.01.3-1.5-1.1-1.3-1.4
Total resting periods, locomotor time 10.80.92.10.7-0.6-0.70.2-0.4-0.91.0-1.5-1.2-1.0-1.4
Rest time, locomotor task time 10.40.61.51.2-1.1-1.10.7-0.7-0.60.4-0.3-0.60.8-0.1
Distance moved, locomotor task time 10.10.41.3-0.30.20.2-0.40.1-0.60.7-0.9-0.3-1.1-0.8
Vertical activity count, locomotor time 10.00.20.5-0.20.10.2-0.50.2-0.20.7-0.4-0.1-0.6-0.4
Time >=10cm from walls, locomotor time 20.41.35.80.7-0.6-0.70.3-1.3-1.52.40.60.90.81.1
Bouts of movement, locomotor time 20.82.86.81.1-1.1-1.40.9-1.4-2.12.6-2.0-1.2-1.9-1.7
Total resting periods, locomotor time 20.62.45.11.3-1.3-1.51.1-1.5-1.82.3-1.6-1.2-1.5-1.4
Rest time, locomotor task time 22.54.29.73.1-3.0-3.02.9-2.3-1.0-0.0-0.2-1.71.00.1
Distance moved, locomotor task time 20.81.04.2-0.80.80.7-0.8-0.1-1.62.1-0.41.0-0.60.2
Vertical activity count, locomotor time 20.92.04.3-2.12.02.0-1.81.0-0.51.7-0.11.4-1.00.2
Light reinforcement 10.83.89.70.7-0.9-1.10.6-1.0-1.72.5-2.7-2.0-3.1-2.8
Light reinforcement 21.33.06.71.5-1.6-1.70.8-0.7-0.51.2-2.4-2.5-1.8-2.6
Bone: marrow area12.330.146.1-6.66.76.8-6.56.55.9-4.84.24.32.83.1
Bone: maximum diameter3.57.113.5-3.23.13.1-3.13.33.7-2.91.80.81.10.8
Bone: maximum force1.12.24.4-1.91.81.8-2.11.91.8-1.0-0.20.1-0.9-0.9
Bone: maximum moment1.32.44.7-2.12.01.9-2.22.01.9-1.0-0.20.1-0.9-0.8
Mean time between licks in bursts0.10.62.0-0.10.1-0.1-0.10.3-0.2-0.1-1.3-1.0-1.0-1.4
Mean num. licks in bursts0.10.20.6-0.20.20.10.20.1-0.10.7-0.70.1-0.7-0.8
Cd content in liver0.80.92.11.5-1.2-1.00.9-0.3-0.8-1.1-0.0-0.41.40.4
Co content in liver0.91.12.91.7-1.7-1.51.1-1.1-1.00.2-0.5-0.60.3-0.3
Cu content in liver0.10.10.3-0.20.30.4-0.50.50.4-0.60.2-0.10.30.2
Fe content in liver1.11.33.4-0.80.70.7-0.90.51.2-0.71.91.21.31.8
K content in liver0.40.32.20.3-0.3-0.2-0.40.41.5-0.90.3-0.10.4-0.1
Mg content in liver0.20.20.50.7-0.6-0.60.4-0.10.3-0.5-0.2-0.60.1-0.3
Mn content in liver0.40.42.0-0.30.30.3-0.40.51.4-1.00.7-0.10.40.2
Na content in liver0.30.30.60.5-0.6-0.50.6-0.30.7-0.50.70.10.80.5
Rb content in liver0.40.51.00.6-0.6-0.61.0-0.40.2-0.90.9-0.31.00.8
Se content in liver1.11.33.31.7-1.8-1.71.5-1.20.20.10.1-1.10.2-0.1
Sr content in liver0.30.20.7-0.10.00.2-0.50.1-0.60.7-0.90.1-0.6-0.7
Zn content in liver0.60.71.51.0-1.0-0.80.6-0.50.4-0.51.00.11.21.1
Bone: minimum diameter7.514.525.8-5.15.05.1-4.95.14.3-3.31.41.20.20.3
Time in familiar zone, hab. session 10.80.92.1-1.11.21.2-1.21.50.6-1.20.2-0.10.20.0
Time in novel zone, hab. session 10.60.71.80.6-0.7-0.71.2-1.2-0.91.3-0.30.4-0.6-0.0
Total zone transitions, hab. session 10.30.41.4-0.60.50.5-0.9-0.0-0.21.2-0.60.5-0.9-0.6
Total locomotion distance, hab. session 10.81.12.6-1.31.11.1-1.60.40.21.1-0.51.1-1.3-0.6
Locomotion velocity, hab. session 10.60.92.8-1.11.00.9-1.70.50.40.9-0.31.1-1.0-0.5
Time in familiar zone, hab. session 21.21.42.1-1.21.31.3-1.21.21.0-0.81.21.51.01.2
Time in novel zone, hab. session 20.70.81.70.9-0.9-0.90.9-0.7-0.30.3-0.9-1.3-0.9-1.1
Total zone transitions, hab. session 20.40.53.1-0.10.0-0.0-0.4-0.7-1.11.8-0.50.5-0.7-0.1
Total locomotion distance, hab. session 20.70.92.6-0.50.40.4-1.00.0-0.61.6-1.20.1-1.5-1.2
Locomotion velocity, hab. session 20.60.82.7-0.30.20.1-0.7-0.2-0.71.6-1.3-0.0-1.4-1.2
Novel to familiar place preference ratio1.01.43.3-1.51.41.4-1.81.51.2-1.20.00.1-0.4-0.4
Novelty place preference0.70.92.5-1.21.21.2-1.61.10.9-0.90.10.3-0.3-0.2
Time in novel zone, NPP test0.70.92.5-1.21.11.1-1.61.10.9-0.90.30.5-0.20.0
Total zone transitions, NPP test0.30.42.2-0.1-0.1-0.1-0.1-0.6-0.41.5-0.40.0-1.0-0.5
Total locomotion distance, NPP test0.50.71.6-1.01.00.9-1.30.40.21.0-0.11.0-0.8-0.3
Locomotion velocity, NPP test0.40.62.0-0.50.30.3-0.7-0.0-0.11.2-0.8-0.0-1.4-1.1
Intraocular pressure0.10.10.5-0.30.20.20.2-0.40.10.50.10.2-0.7-0.0
Delta distance traveled before/after self-admin0.40.51.4-1.21.11.1-0.50.3-0.10.40.40.5-0.50.5
Delta ambulatory time before/after self-admin0.61.02.8-1.61.61.7-0.81.10.4-0.60.30.3-0.50.4
Parametrial fat weight0.20.52.10.00.20.3-0.71.10.9-1.5-0.2-0.70.5-0.4
Pavlov. Cond. lever latency0.60.72.80.9-0.7-0.60.70.10.1-1.3-0.6-1.70.3-0.7
Pavlov. Cond. magazine entry latency1.41.83.7-1.71.61.6-1.91.41.7-0.51.01.4-0.10.5
Pavlov. Cond. change in total contacts1.51.65.2-1.61.51.4-1.50.80.80.31.12.30.11.0
Pavlov. Cond. index score1.01.32.8-1.51.31.3-1.50.91.10.21.01.7-0.10.6
Pavlov. Cond. latency score0.70.92.4-1.31.01.0-1.20.50.70.50.81.6-0.20.6
Pavlov. Cond. lever contacts0.60.73.3-0.80.60.6-0.9-0.0-0.21.20.51.8-0.10.7
Pavlov. Cond. magazine entry number1.11.42.81.4-1.3-1.31.5-1.2-1.70.8-1.1-1.3-0.1-0.5
Pavlov. Cond. intertrial magazine entries1.21.53.6-1.31.31.3-1.61.51.9-1.0-0.3-0.3-0.8-0.9
Pavlov. Cond. lever-magazine prob. diff.1.01.32.6-1.51.31.2-1.50.91.20.21.01.6-0.10.6
Pavlov. Cond. response bias1.62.03.7-1.81.61.6-1.81.31.6-0.41.31.90.20.8
Pavlov. Cond. lever latency1.01.42.41.5-1.5-1.41.0-1.0-1.30.7-1.5-1.1-0.5-1.1
Pavlov. Cond. magazine entry latency0.91.33.91.4-1.4-1.42.0-1.4-0.70.00.8-0.70.80.7
Pavlov. Cond. change in total contacts0.61.64.0-1.11.01.0-0.70.81.0-0.92.01.31.51.8
Pavlov. Cond. index score0.61.03.4-0.80.70.7-0.00.30.8-0.71.80.91.11.6
Pavlov. Cond. latency score0.71.14.1-0.60.50.50.30.10.7-0.82.00.91.31.8
Pavlov. Cond. lever contacts0.60.91.9-1.41.31.2-0.90.81.0-0.41.20.80.10.9
Pavlov. Cond. magazine entry number1.51.94.9-1.61.71.7-2.21.80.9-0.2-1.00.4-1.1-1.1
Pavlov. Cond. intertrial magazine entries2.55.512.9-3.13.13.1-3.63.21.5-0.7-1.20.2-1.6-1.4
Pavlov. Cond. lever-magazine prob. diff.0.60.93.5-0.60.60.60.10.20.8-0.81.90.81.11.6
Pavlov. Cond. response bias0.40.61.6-0.90.80.8-0.50.50.8-0.41.30.60.51.0
Time in closed arm before self-admin0.40.61.7-1.31.21.1-0.20.1-0.30.60.61.0-0.70.6
Time in closed arm after self-admin0.20.20.6-0.30.40.3-0.0-0.1-0.40.20.60.80.40.8
Time in open arm before self-admin0.70.91.81.3-1.3-1.31.1-1.2-1.00.7-0.10.10.30.2
Time in open arm after self-admin0.40.51.31.1-1.1-1.10.5-0.60.10.1-0.1-0.90.3-0.3
Bone: periosteal estimation6.916.428.7-5.45.35.3-5.15.04.4-3.12.52.51.01.4
Bone: periosteal perimeter2.95.711.0-2.82.82.8-2.72.93.3-2.41.81.01.11.0
Bone: post-yield work1.11.93.3-1.81.71.7-1.81.71.6-1.20.60.80.20.1
Progressive ratio test 1 active lever presses1.42.45.9-2.42.32.2-1.81.41.20.3-0.10.6-1.7-0.5
Progressive ratio test 1 breakpoint1.62.76.5-2.52.42.3-2.01.51.20.3-0.20.6-1.8-0.7
Progressive ratio test 1 inactive lever presses1.23.27.3-2.62.52.4-2.71.71.70.20.31.2-1.1-0.1
Progressive ratio test 2 active lever presses1.01.53.9-1.61.51.4-1.71.52.0-0.50.60.0-0.3-0.1
Progressive ratio test 2 breakpoint1.31.74.2-1.71.61.6-1.81.62.0-0.60.70.1-0.20.0
Progressive ratio test 2 inactive lever presses0.41.43.0-1.11.01.0-1.71.11.20.3-0.9-0.6-1.6-1.6
Incentive Sensitization - Responses0.10.31.60.1-0.1-0.1-0.90.41.3-0.30.5-0.30.80.2
Incentive Sensitization - Breakpoint0.20.41.80.0-0.1-0.1-0.90.51.3-0.40.7-0.21.00.4
Sum of active levers in priming session hrs 5-60.40.41.10.5-0.5-0.50.8-1.0-0.70.60.20.50.20.6
Progressive ratio0.30.81.61.2-1.2-1.10.20.01.1-1.1-0.0-0.71.0-0.4
Food seeking constrained by brief footshock2.93.66.4-2.32.32.4-1.91.90.9-1.71.52.51.21.8
Seeking ratio, punishment vs. effort1.02.15.1-2.32.22.1-1.51.10.00.00.81.8-0.11.2
Retroperitoneal fat weight0.52.46.2-0.50.50.4-1.60.4-0.92.0-2.5-0.8-2.4-2.2
Reaction time number correct0.10.40.90.7-0.7-0.90.9-0.60.1-0.30.3-0.90.2-0.3
Reaction time mean minus median0.00.20.50.5-0.4-0.20.3-0.2-0.7-0.1-0.7-0.3-0.3-0.6
Reaction time mean minus median AUC0.00.10.90.2-0.1-0.00.30.00.1-0.9-0.2-0.3-0.3-0.5
Reaction time num false alarms1.22.13.6-1.91.71.7-1.71.41.7-0.31.61.50.50.9
Reaction time num false alarms AUC1.12.65.0-2.22.12.0-1.91.71.8-0.71.51.40.40.7
Reaction time trials correct on left0.10.40.90.7-0.7-0.90.9-0.60.1-0.30.3-0.90.2-0.3
Reaction time trials on left0.10.40.90.7-0.7-0.90.9-0.60.1-0.40.3-1.00.2-0.3
Reaction time mean0.10.31.40.4-0.3-0.00.00.10.4-1.20.70.30.90.6
Reaction time mean AUC0.10.30.70.4-0.3-0.10.2-0.10.0-0.80.70.60.80.8
Median of all reaction times0.30.51.50.3-0.20.1-0.10.20.6-1.21.00.41.00.9
Reaction time omissions0.40.61.4-0.80.90.9-0.91.20.1-0.8-0.6-0.4-0.7-0.8
Reaction time false alarm rate1.82.64.6-2.12.02.1-1.91.61.3-0.31.41.90.51.1
Reaction time premature initiation rate0.30.41.0-0.60.50.5-1.00.60.30.4-0.8-0.4-0.9-0.8
Reaction time premature initiations0.10.20.7-0.20.10.1-0.40.30.20.1-0.6-0.8-0.8-0.8
Std. dev. reaction times0.10.31.60.10.10.3-0.20.50.1-1.30.30.60.80.4
Reaction time trials completed0.10.40.90.7-0.7-0.90.9-0.60.1-0.40.3-1.00.2-0.3
Reaction time trials AUC0.10.30.90.6-0.6-0.80.8-0.50.1-0.30.2-1.00.2-0.4
Run reversals in cocaine runway, females3.54.07.91.6-1.5-1.81.4-1.6-2.32.8-2.7-1.6-1.9-2.1
Run reversals in cocaine runway, males0.30.30.70.8-0.8-0.70.1-0.20.4-0.3-0.1-0.80.4-0.5
Latency to leave start box in cocaine runway0.50.73.10.5-0.5-0.70.6-1.2-1.11.70.30.40.10.6
Latency to leave start box in cocaine runway, F1.01.33.40.9-1.0-1.21.0-1.8-0.91.80.80.40.61.1
Latency to leave start box in cocaine runway, M0.20.20.8-0.40.50.4-0.20.1-0.90.8-0.30.6-0.30.0
Std. dev. time between licks in bursts0.81.53.30.7-0.7-0.90.5-0.7-1.51.1-1.8-1.6-1.4-1.6
Total sessions with >9 infusions0.70.83.8-0.2-0.0-0.10.3-0.7-0.31.5-1.0-0.6-2.0-1.0
Short access day 1 total inactive lever presses0.40.82.6-0.70.50.5-1.60.51.20.4-0.8-0.4-1.1-1.0
Short access day 10 total inactive lever presses0.10.62.30.3-0.3-0.2-0.90.20.10.5-1.4-0.7-0.7-1.5
Short access day 1 total infusions0.40.93.20.2-0.5-0.6-0.2-0.80.41.3-1.1-0.7-1.8-1.2
Short access day 10 total infusions1.62.65.8-2.42.22.2-1.81.51.10.4-0.70.2-2.2-1.1
Short access total infusions0.60.91.8-1.31.11.0-1.30.61.10.5-0.20.5-1.3-0.4
Short access day 1 locomotion2.03.312.6-0.60.40.2-0.80.00.32.0-2.4-1.8-3.5-3.0
Short access day 10 total locomotion0.93.67.5-2.72.62.5-2.72.11.4-0.0-0.71.2-1.6-0.7
Short access total locomotion1.52.27.9-1.31.11.0-1.30.60.51.7-1.8-0.5-2.8-2.1
One hour access (0.3 mA shock)1.01.22.3-1.51.51.5-0.81.01.1-0.91.11.00.21.0
Compulsive drug intake0.81.13.3-0.50.60.50.80.30.3-1.81.61.01.01.6
One hour access (shock baseline)0.20.51.2-0.80.70.8-1.10.70.70.6-0.4-0.1-0.7-0.6
Social response proportion0.20.30.6-0.80.80.70.10.50.5-0.70.60.2-0.10.5
Social responses1.21.64.6-2.12.11.8-0.91.00.4-0.10.81.3-0.90.5
Social time0.40.61.70.2-0.1-0.10.8-0.1-0.0-0.71.30.51.31.3
Soleus weight0.00.10.30.1-0.3-0.30.1-0.40.20.50.50.10.30.3
Bone: stiffness0.71.32.2-1.51.41.5-1.51.51.5-0.90.20.4-0.4-0.4
Tibialis anterior weight0.72.47.1-0.10.10.1-0.3-0.4-1.62.7-2.3-1.4-2.2-2.0
Time to tail flick, vehicle, before self-admin1.51.85.60.00.10.20.20.71.3-2.41.80.92.41.6
Time to tail flick, vehicle, after self-admin0.30.52.60.1-0.0-0.10.50.51.1-1.60.3-1.10.4-0.4
Time to tail flick, test, before self-admin1.01.11.8-1.11.21.2-0.81.00.5-1.10.91.41.01.1
Time to tail flick, test, after self-admin0.91.02.0-1.41.41.4-0.51.10.8-1.20.90.60.10.7
Delta time to tail flick, vehicle, before/after SA0.60.71.1-0.91.00.9-0.81.10.3-0.4-0.8-0.4-1.0-1.0
Delta time to tail flick, test, before/after SA0.30.41.20.0-0.00.0-0.20.31.1-1.00.9-0.20.80.3
Tibia length0.10.20.5-0.30.20.20.30.00.7-0.40.7-0.6-0.10.1
Ambulatory time before self-admin0.30.81.31.0-1.1-1.10.9-1.10.2-0.20.90.51.10.8
Ambulatory time after self-admin0.20.30.8-0.50.50.4-0.40.10.7-0.40.90.70.50.9
Bone: tissue strength0.60.61.51.1-1.2-1.20.9-1.1-0.10.20.3-0.80.30.2
Total heroin consumption1.01.23.6-0.60.50.5-0.20.10.9-0.61.91.61.31.7
Bone: trabecular number0.30.61.7-0.70.70.7-0.71.11.3-1.20.1-0.40.3-0.3
Bone: trabecular spacing0.20.20.70.2-0.2-0.30.4-0.6-0.80.70.40.40.20.7
Bone: trabecular thickness0.60.81.5-0.70.70.8-0.61.11.0-1.0-0.8-1.1-0.8-1.2
Bone: trabecular tissue density1.01.84.01.3-1.4-1.31.1-0.9-0.60.6-1.5-2.0-1.4-1.7
Water consumed over 24 hours0.30.72.0-0.30.20.1-0.1-0.2-0.91.3-1.20.4-1.4-0.9
Number of responses in last shaping day0.60.82.10.8-0.9-0.9-0.3-0.7-0.11.5-0.9-0.4-0.8-1.3