Hub : Genes

Cacng4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Cacng4 0.06 0.04 1.1e-05 0.06 0.04 0.05 0.04 1.1e-06 1.3e-05 5.9e-06 1.0e-05
2 NAcc gene expression Cacng4 0.14 0.06 5.0e-16 0.15 0.13 0.12 0.14 4.5e-17 4.6e-15 3.7e-14 7.7e-16
3 NAcc mRNA stability Cacng4 0.04 0.02 6.4e-06 0.06 0.04 0.04 0.05 1.2e-07 2.3e-05 9.4e-06 8.3e-07
4 BLA gene expression Cacng4 0.13 0.07 1.2e-05 0.08 0.02 0.03 0.05 4.1e-05 2.2e-02 1.1e-02 8.6e-04
5 Liver gene expression Cacng4 0.13 0.06 0.0e+00 0.12 0.15 0.15 0.14 1.1e-13 1.8e-16 3.6e-16 1.1e-15
6 Brain gene expression Cacng4 0.22 0.08 0.0e+00 0.14 0.16 0.2 0.18 1.2e-12 3.9e-15 3.8e-18 1.2e-16
7 Adipose gene expression Cacng4 0.14 0.06 1.7e-09 0.08 0.07 0.05 0.07 2.7e-09 2.4e-08 4.1e-06 1.6e-08
8 pVTA gene expression Cacng4 0.25 0.12 3.3e-05 0.03 0.08 0.1 0.11 2.1e-02 3.3e-04 5.5e-05 1.3e-05
9 PL gene expression Cacng4 0.08 0.04 5.2e-05 0.02 0.04 0.04 0.03 6.5e-03 1.5e-05 1.7e-05 6.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.30.51.20.8-0.80.6-0.71.1-0.3-1.00.1-0.2
Area under the delay curve0.60.61.1-0.80.8-1.10.8-0.10.9-0.8-0.7-0.6
BMI with tail2.16.819.4-0.50.4-0.40.4-1.42.54.2-3.9-4.4
BMI without tail2.65.318.01.2-1.31.7-1.20.31.13.0-3.4-4.2
Body weight0.93.99.62.0-2.12.1-2.01.3-0.11.6-2.0-3.1
Weight adjusted by age2.22.56.2-1.91.9-2.51.8-1.61.50.3-1.00.2
Bone surface4.07.110.22.9-2.92.7-2.83.2-2.8-2.72.11.5
Bone volume2.54.27.62.3-2.32.0-2.22.8-1.8-2.41.30.6
Breakpoint value in progressive ratio session0.40.40.8-0.80.8-0.40.8-0.90.10.60.60.5
Number of licking bursts0.10.10.40.1-0.10.3-0.10.1-0.4-0.20.60.5
Context. condit. distance diff. score0.10.10.2-0.50.4-0.30.4-0.20.40.1-0.0-0.2
Locomotion velocity, session 10.20.20.50.4-0.50.7-0.50.4-0.6-0.10.40.2
Locomotion distance, session 10.00.00.10.0-0.10.3-0.1-0.0-0.3-0.1-0.30.1
Locomotion velocity, session 21.61.94.91.1-1.21.2-1.10.3-2.2-0.01.91.8
Locomotion distance, session 20.20.31.00.3-0.30.3-0.3-0.4-1.00.50.30.6
Locomotion velocity, session 31.31.52.9-1.51.4-1.51.4-1.70.81.2-0.4-0.1
Locomotion distance, session 30.30.30.8-0.50.3-0.40.4-0.2-0.3-0.50.80.9
Stereotopy head waving bouts, day 31.92.23.9-1.92.0-1.61.9-1.41.70.5-0.8-0.5
Stereotopy head waving duration, day 31.51.83.3-1.71.8-1.71.7-1.31.50.2-0.7-0.4
Locomotion velocity, session 70.30.30.6-0.70.6-0.30.6-0.70.30.80.10.2
Locomotion distance, session 70.10.10.10.3-0.30.4-0.30.3-0.3-0.3-0.0-0.0
Stereotopy head waving bouts, day 71.61.83.6-1.51.5-1.91.6-1.80.71.2-0.20.4
Stereotopy head waving duration, day 72.42.95.6-1.92.0-2.42.1-2.20.61.00.71.3
Locomotion velocity, session 80.50.61.50.4-0.50.6-0.50.5-1.0-0.31.21.1
Locomotion distance, session 80.20.30.80.4-0.50.5-0.50.1-0.90.00.60.6
Degree of sensitization distance0.30.30.50.6-0.50.7-0.60.7-0.1-0.2-0.6-0.5
Degree of sensitization stereotypy1.31.43.4-1.11.1-1.61.2-1.80.01.50.30.9
Conditioned locomotion0.10.10.20.1-0.0-0.0-0.10.10.10.4-0.5-0.3
Cocaine response after cond. corrected0.20.20.5-0.50.5-0.70.6-0.30.3-0.50.10.3
Cocaine response after cond. not corrected0.70.82.8-0.50.5-0.70.6-0.5-0.6-0.61.41.7
Cocaine response before conditioning0.70.93.3-0.20.2-0.00.1-0.2-1.1-0.31.81.8
Saline control response0.81.13.40.6-0.50.6-0.7-0.20.41.8-1.3-1.7
Bone: connectivity density0.71.11.81.2-1.21.1-1.21.4-0.9-1.30.50.3
Bone: cortical apparent density5.67.412.4-2.72.7-2.52.6-2.23.52.2-3.0-2.8
Bone: cortical area1.01.62.81.6-1.71.2-1.51.3-0.60.4-0.8-1.5
Bone: cortical porosity5.56.010.42.7-2.72.6-2.72.0-3.2-1.12.61.8
Bone: cortical porosity3.33.66.22.2-2.22.0-2.21.6-2.5-1.11.81.2
Bone: cortical thickness6.310.416.6-2.42.4-2.72.6-3.03.54.1-4.0-3.7
Bone: cortical thickness2.42.86.6-1.01.0-1.11.1-1.51.62.6-2.2-2.1
Bone: cortical tissue density5.37.011.9-2.62.7-2.52.5-2.23.42.1-2.9-2.7
Condit. Reinf. active minus inactive responses3.64.15.82.0-2.12.1-2.12.0-2.4-2.12.01.2
Condit. Reinf. active-inactive response ratio1.71.93.21.1-1.11.2-1.11.3-1.5-1.81.81.2
Condit. Reinf. active responses3.64.46.52.2-2.32.2-2.22.2-2.6-2.01.81.1
Condit. Reinf. inactive responses0.80.91.41.1-1.20.8-1.11.2-1.2-0.80.30.2
Incentive salience index mean2.32.84.51.7-1.71.7-1.81.5-2.1-1.41.81.0
Condit. Reinf. lever presses0.10.20.60.2-0.20.1-0.3-0.2-0.70.40.70.5
Condit. Reinf. active minus inactive responses5.87.211.93.0-3.02.5-3.02.6-3.5-2.22.31.6
Condit. Reinf. active-inactive response ratio4.24.47.42.3-2.31.8-2.31.9-2.7-1.72.11.6
Condit. Reinf. active responses6.28.612.73.4-3.43.2-3.53.1-3.6-2.12.11.3
Condit. Reinf. inactive responses1.72.14.31.7-1.82.1-1.81.7-1.4-0.60.1-0.3
Condit. Reinf. lever presses3.44.78.52.9-2.92.5-2.91.9-2.5-0.10.80.1
Condit. Reinf. lever reinforcers received5.67.911.53.3-3.33.1-3.43.0-3.3-2.01.81.1
Conditioned reinforcement - actives0.40.41.00.7-0.81.0-0.80.3-0.60.30.2-0.2
Conditioned reinforcement - inactives0.60.71.31.0-0.91.1-0.81.1-0.8-0.7-0.4-0.4
Conditioned locomotion1.51.84.41.7-1.52.1-1.51.7-0.7-0.1-0.3-1.2
Patch foraging indifference point 0 sec3.86.09.83.1-3.13.1-3.03.1-1.7-1.1-0.4-1.6
Patch foraging indifference point AUC0.40.41.90.6-0.61.4-0.60.7-0.40.3-0.2-0.3
Delay disc. indifference point, 0s delay0.70.82.0-1.01.0-1.40.9-0.80.9-0.3-0.70.1
Delay disc. indifference point, 16s delay0.50.61.6-0.40.5-0.60.5-0.11.00.0-1.2-1.3
Delay disc. indifference point, 2s delay0.60.74.50.00.00.1-0.11.10.0-2.10.1-0.2
Delay disc. indifference point, 24s delay1.01.04.40.3-0.30.5-0.40.70.80.2-1.5-2.1
Delay disc. indifference point, 4s delay0.60.62.1-0.80.8-1.40.8-0.70.3-0.50.30.8
Delay disc. indifference point, 8s delay1.92.03.2-1.71.7-1.81.6-0.81.8-0.2-1.3-1.0
Indifference point function ln k0.20.31.4-0.50.7-1.20.7-0.50.40.20.10.0
Indifference point function log k0.20.31.4-0.50.7-1.20.7-0.50.40.20.10.0
Patch foraging total patch changes 0 sec3.65.89.33.1-3.03.0-2.93.0-1.7-1.1-0.5-1.5
Patch foraging total patch changes 12 sec4.05.110.02.6-2.83.2-2.62.9-1.8-1.50.3-0.6
Patch foraging total patch changes 18 sec1.01.23.01.3-1.31.7-1.31.2-0.90.1-0.4-0.7
Patch foraging total patch changes 24 sec2.22.75.51.8-1.92.3-1.92.0-1.2-0.7-1.0-1.2
Patch foraging total patch changes 6 sec3.34.98.92.7-2.83.0-2.72.7-1.8-1.3-0.0-0.9
Patch foraging time to switch 0 sec0.10.20.4-0.60.4-0.60.3-0.70.40.40.0-0.1
Patch foraging water rate 0 sec1.01.73.01.7-1.61.7-1.41.7-0.6-0.3-0.7-1.0
Patch foraging water rate 12 sec0.20.31.0-0.10.3-0.30.4-0.60.50.7-1.0-0.7
Patch foraging water rate 18 sec0.00.10.40.00.0-0.00.10.10.2-0.1-0.4-0.6
Patch foraging water rate 24 sec0.30.41.1-0.71.0-0.51.0-0.40.4-0.70.20.4
Patch foraging water rate 6 sec0.50.81.4-0.60.9-0.91.0-0.70.90.5-1.2-0.8
Seeking ratio, delayed vs. immediate footshock0.40.51.6-0.60.3-0.20.4-0.20.70.6-1.3-1.0
Distance traveled before self-admin1.01.02.6-0.90.9-0.80.9-0.7-0.4-0.91.41.6
Distance traveled after self-admin0.80.83.4-0.30.1-0.30.1-0.5-1.0-0.51.51.8
Extensor digitorum longus weight1.97.512.2-2.52.5-2.52.6-2.63.52.9-3.3-2.1
Bone: elastic displacement0.60.71.5-1.11.0-1.01.0-1.20.40.90.20.1
Bone: elastic work0.30.41.50.1-0.20.1-0.2-0.00.51.0-0.7-1.2
Bone: endosteal estimation16.636.346.36.8-6.86.5-6.66.7-6.6-5.14.83.1
Bone: endosteal perimeter14.129.339.66.0-6.05.7-5.86.3-5.8-5.24.42.8
Epididymis fat weight1.33.110.4-0.20.1-0.00.1-0.12.11.8-3.1-3.2
Delta time in closed arm before/after self-admin0.40.41.3-0.10.20.00.20.3-0.5-1.10.91.2
Delta time in open arm before/after self-admin1.21.22.3-1.11.1-1.51.1-0.91.20.5-1.3-0.6
Diff in mean of infusions in LGA sessions1.92.04.8-1.31.4-0.81.3-1.71.52.2-1.1-1.2
Delay discount exponential model param0.30.31.00.5-0.50.7-0.4-0.3-0.71.00.40.5
Extinction: sum of active levers before priming0.20.20.6-0.20.3-0.50.2-0.20.50.4-0.8-0.5
Active lever presses in extinction session 60.90.92.81.0-1.11.7-1.21.0-0.60.00.3-0.5
Bone: final force1.22.03.61.8-1.71.6-1.71.9-1.1-1.10.1-0.7
Bone: final moment1.42.23.91.9-1.81.7-1.82.0-1.2-1.10.2-0.6
Food consumed during 24 hour testing period1.31.64.51.2-1.20.9-1.10.50.31.4-1.7-2.1
Glucose0.61.01.9-1.41.2-0.81.2-1.30.80.9-0.00.4
Heart weight0.00.10.3-0.10.0-0.50.2-0.10.0-0.2-0.30.0
Delay discount hyperbolic model param0.40.41.20.6-0.60.8-0.6-0.2-0.71.10.50.5
Intermittent access intake day 1-15 change0.90.91.21.0-1.10.7-1.00.8-1.0-0.71.11.1
Intermittent access intake escalation0.60.61.00.7-0.80.4-0.70.6-0.8-0.70.91.0
Intermittent access intake escalation 22.12.13.01.7-1.71.7-1.71.6-1.4-0.91.21.0
Intermitt. access day 1 inactive lever presses1.71.83.91.6-1.41.6-1.41.2-2.0-0.70.90.7
Intermitt. access day 15 inactive lever presses0.20.20.50.4-0.20.7-0.30.4-0.20.3-0.4-0.5
Intermitt. access escalation Index0.60.52.0-0.10.2-0.40.3-0.8-0.60.31.11.4
Intermittent access day 1 total infusions0.40.51.60.8-0.60.7-0.60.5-0.20.2-0.8-1.2
Intermittent access day 15 total infusions1.01.12.61.6-1.51.2-1.41.1-0.9-0.30.0-0.4
Intermittent access terminal intake (last 3 days)2.62.85.32.3-2.22.0-2.11.9-1.4-0.90.3-0.4
Intermittent access total infusions2.02.23.92.0-1.91.8-1.91.7-1.3-0.70.0-0.7
Intermittent access day 1 locomotion1.31.32.31.5-1.21.5-1.21.4-0.7-0.3-0.7-1.3
Intermittent access day 15 total locomotion3.13.35.82.3-2.12.4-2.12.4-1.5-0.90.3-0.7
Intermittent access total locomotion4.55.18.92.9-2.73.0-2.72.8-1.6-0.6-0.6-1.8
Intermittent access standard deviation0.60.71.41.0-0.91.2-0.91.0-0.4-0.1-0.3-0.6
Left kidney weight0.30.81.8-0.60.6-0.60.6-1.20.41.3-1.0-0.9
Right kidney weight0.10.41.60.4-0.50.3-0.5-0.4-0.21.3-0.7-0.8
Cocaine induced anxiety0.00.00.1-0.10.20.10.2-0.0-0.1-0.30.10.2
Post-drug Anxiety0.91.01.8-1.31.4-1.01.4-0.81.1-0.1-0.5-0.1
Baseline Anxiety2.32.43.8-1.81.7-1.61.7-1.52.01.2-1.3-1.0
Tail length1.23.77.52.3-2.52.7-2.42.3-1.5-0.80.2-0.5
Length with tail1.13.96.42.1-2.12.1-2.22.5-2.0-2.21.30.7
Length without tail0.20.52.1-0.10.1-0.40.00.5-0.4-1.41.01.0
Times rat made contact with spout0.80.91.81.3-1.31.0-1.30.8-1.20.10.60.4
Lifetime Intake1.82.03.41.8-1.81.8-1.81.5-1.1-0.3-0.4-1.1
Liver weight, left0.30.51.10.3-0.30.7-0.40.7-0.6-0.91.10.9
Liver weight, right0.20.40.7-0.60.8-0.50.7-0.50.60.3-0.8-0.4
Locomotor activity1.42.23.82.0-1.92.0-1.90.8-1.71.00.3-0.6
Locomotor testing distance0.91.52.81.7-1.51.6-1.40.6-1.61.20.3-0.3
Locomotor testing rearing1.11.83.81.5-1.31.5-1.30.3-2.01.41.11.1
Locomotion in novel chamber0.91.13.3-1.21.1-0.91.1-0.3-0.0-1.80.81.1
Locomotion in novel chamber post-restriction1.41.77.40.7-0.80.9-0.91.9-1.0-2.70.90.4
Fecal boli incidents, locomotor time 10.40.40.8-0.70.7-0.80.8-0.20.3-0.90.60.4
Change in fecal boli incidents, locomotor task0.30.30.70.5-0.50.5-0.50.50.40.3-0.8-0.8
Time >=10cm from walls, locomotor time 10.80.81.7-0.90.9-0.80.9-0.9-0.3-0.21.31.3
Bouts of movement, locomotor time 10.91.02.4-0.70.7-0.60.7-0.71.20.9-1.5-1.4
Total resting periods, locomotor time 10.80.92.1-0.80.7-0.70.8-0.61.30.6-1.5-1.2
Rest time, locomotor task time 10.70.81.6-1.11.1-1.31.2-0.80.8-0.3-0.20.6
Distance moved, locomotor task time 10.30.30.90.4-0.40.7-0.40.30.20.7-0.6-1.0
Vertical activity count, locomotor time 10.10.10.20.4-0.40.5-0.50.3-0.10.2-0.2-0.5
Time >=10cm from walls, locomotor time 20.60.71.6-0.70.6-0.90.6-1.30.01.10.51.0
Bouts of movement, locomotor time 22.12.34.0-1.11.1-1.11.2-1.41.72.0-2.0-1.7
Total resting periods, locomotor time 22.12.23.3-1.31.4-1.41.4-1.41.71.6-1.8-1.4
Rest time, locomotor task time 24.95.610.2-3.23.1-3.23.2-2.32.10.1-0.60.6
Distance moved, locomotor task time 20.70.83.50.9-0.91.0-0.9-0.1-0.41.9-0.3-0.4
Vertical activity count, locomotor time 22.62.85.42.3-2.32.1-2.31.1-1.31.20.1-0.6
Light reinforcement 11.73.19.0-1.00.7-0.70.8-0.92.01.8-3.0-3.0
Light reinforcement 21.62.24.2-1.61.3-1.11.2-0.52.00.2-2.1-2.0
Bone: marrow area16.435.645.26.7-6.76.5-6.66.6-6.6-5.14.83.2
Bone: maximum diameter4.68.513.03.3-3.33.0-3.13.6-3.0-3.02.01.0
Bone: maximum force1.83.15.32.2-2.22.0-2.12.3-1.2-1.2-0.3-1.1
Bone: maximum moment2.03.45.82.3-2.42.1-2.22.4-1.3-1.2-0.2-1.0
Mean time between licks in bursts0.20.20.90.0-0.00.20.00.20.60.1-0.9-1.0
Mean num. licks in bursts0.20.20.60.4-0.40.0-0.30.20.30.4-0.8-0.7
Cd content in liver1.01.12.0-1.41.3-1.31.3-0.70.9-0.50.40.8
Co content in liver0.50.61.9-0.90.6-0.60.6-0.30.1-0.51.41.1
Cu content in liver0.10.10.20.3-0.30.3-0.30.4-0.2-0.40.20.0
Fe content in liver0.10.10.30.2-0.10.1-0.10.1-0.6-0.30.30.4
K content in liver0.50.52.2-0.10.1-0.00.10.7-0.3-1.51.10.6
Mg content in liver0.30.31.4-0.20.2-0.00.20.60.1-1.20.80.3
Mn content in liver0.40.41.90.4-0.40.5-0.40.9-0.4-1.40.70.2
Na content in liver0.40.41.0-0.70.7-0.70.7-0.20.1-0.61.00.4
Rb content in liver0.30.41.3-0.30.4-0.30.4-0.1-0.3-0.90.91.1
Se content in liver2.12.54.8-2.22.2-2.12.2-1.51.2-0.1-0.00.5
Sr content in liver0.10.10.2-0.1-0.30.2-0.20.00.20.4-0.2-0.4
Zn content in liver0.70.71.1-1.10.9-0.90.9-0.40.1-1.01.01.0
Bone: minimum diameter9.117.127.15.1-5.24.6-4.95.2-3.8-3.12.00.3
Time in familiar zone, hab. session 11.11.01.91.2-1.11.1-1.11.4-0.7-1.00.30.2
Time in novel zone, hab. session 10.70.72.3-0.70.6-0.60.6-1.20.61.5-0.7-0.6
Total zone transitions, hab. session 10.30.40.80.5-0.50.6-0.6-0.0-0.20.9-0.8-0.9
Total locomotion distance, hab. session 10.71.01.51.1-1.11.2-1.20.5-0.60.8-0.9-1.2
Locomotion velocity, hab. session 10.50.71.11.0-1.01.0-1.00.6-0.60.3-0.7-0.9
Time in familiar zone, hab. session 21.51.62.41.3-1.21.3-1.31.3-1.5-0.81.31.1
Time in novel zone, hab. session 20.90.91.6-0.90.8-0.90.9-0.81.30.4-1.2-1.1
Total zone transitions, hab. session 20.40.52.7-0.0-0.10.1-0.0-0.80.11.6-0.6-0.6
Total locomotion distance, hab. session 20.60.82.20.5-0.50.6-0.5-0.00.31.2-1.4-1.5
Locomotion velocity, hab. session 20.50.72.10.2-0.30.3-0.3-0.20.41.2-1.5-1.4
Novel to familiar place preference ratio1.41.52.71.4-1.41.6-1.41.6-0.9-1.00.5-0.4
Novelty place preference1.01.02.01.1-1.11.4-1.11.2-0.8-0.80.5-0.2
Time in novel zone, NPP test0.91.02.01.1-1.11.4-1.11.1-0.9-0.70.6-0.1
Total zone transitions, NPP test0.30.51.5-0.20.1-0.30.1-0.70.31.2-1.2-1.0
Total locomotion distance, NPP test0.50.61.01.0-1.00.8-0.90.4-0.50.7-0.8-0.8
Locomotion velocity, NPP test0.50.72.70.4-0.40.2-0.4-0.10.30.9-1.6-1.4
Intraocular pressure0.20.31.3-0.0-0.20.0-0.2-0.50.10.8-1.2-0.8
Delta distance traveled before/after self-admin0.40.42.20.1-0.2-0.3-0.2-0.70.11.5-0.8-0.5
Delta ambulatory time before/after self-admin0.50.61.31.0-1.10.5-1.10.3-0.40.8-0.5-0.4
Parametrial fat weight0.61.12.60.8-1.01.4-1.11.6-0.0-1.3-0.2-0.9
Pavlov. Cond. lever latency0.40.51.2-0.90.7-0.70.9-0.31.1-0.7-0.5-0.0
Pavlov. Cond. magazine entry latency1.51.92.91.6-1.71.6-1.61.4-1.7-0.81.20.2
Pavlov. Cond. change in total contacts1.41.52.91.5-1.51.3-1.50.9-1.70.21.10.4
Pavlov. Cond. index score0.91.22.31.4-1.31.1-1.31.0-1.5-0.20.90.1
Pavlov. Cond. latency score0.60.81.71.1-1.00.8-1.10.6-1.30.20.80.1
Pavlov. Cond. lever contacts0.30.31.30.5-0.40.3-0.5-0.2-0.81.10.40.1
Pavlov. Cond. magazine entry number1.31.62.2-1.41.4-1.21.4-1.31.51.2-1.3-0.3
Pavlov. Cond. intertrial magazine entries1.11.32.51.3-1.21.4-1.31.6-0.6-1.1-0.5-0.8
Pavlov. Cond. lever-magazine prob. diff.0.80.92.01.2-1.10.9-1.20.8-1.4-0.10.90.2
Pavlov. Cond. response bias1.01.22.31.3-1.21.1-1.31.0-1.5-0.51.10.3
Pavlov. Cond. lever latency0.91.22.4-1.31.3-0.91.2-0.91.50.5-0.9-0.7
Pavlov. Cond. magazine entry latency1.11.32.8-1.41.3-1.71.4-1.40.50.30.40.9
Pavlov. Cond. change in total contacts0.81.12.30.9-0.90.4-0.90.7-1.5-0.81.41.4
Pavlov. Cond. index score0.40.51.50.6-0.60.2-0.60.2-1.2-0.21.01.1
Pavlov. Cond. latency score0.50.61.80.5-0.5-0.0-0.50.0-1.2-0.31.21.3
Pavlov. Cond. lever contacts0.60.91.71.3-1.30.9-1.20.7-1.30.10.30.1
Pavlov. Cond. magazine entry number1.41.73.41.5-1.51.8-1.51.7-0.5-0.5-0.4-1.1
Pavlov. Cond. intertrial magazine entries4.55.911.63.0-3.03.4-3.03.1-1.3-0.8-0.4-1.3
Pavlov. Cond. lever-magazine prob. diff.0.40.51.40.5-0.50.0-0.50.1-1.2-0.31.11.2
Pavlov. Cond. response bias0.30.41.00.8-0.80.5-0.80.5-1.0-0.10.40.4
Time in closed arm before self-admin0.60.72.10.9-1.00.8-1.0-0.2-0.61.40.2-0.4
Time in closed arm after self-admin1.01.12.20.9-0.91.0-1.00.2-1.3-0.01.51.3
Time in open arm before self-admin0.80.81.8-1.01.4-1.11.3-1.00.5-0.00.20.5
Time in open arm after self-admin1.71.94.6-1.61.8-2.11.7-0.81.4-0.5-1.0-0.2
Bone: periosteal estimation9.820.330.95.5-5.65.1-5.35.3-4.7-3.22.61.0
Bone: periosteal perimeter4.37.210.23.0-3.12.7-2.83.2-2.9-2.62.21.1
Bone: post-yield work1.72.33.71.8-1.81.7-1.71.9-1.4-1.30.90.4
Progressive ratio test 1 active lever presses2.52.64.92.2-2.11.9-2.21.5-1.40.1-0.3-1.2
Progressive ratio test 1 breakpoint2.93.05.62.4-2.32.0-2.31.5-1.40.4-0.6-1.6
Progressive ratio test 1 inactive lever presses2.42.64.72.2-2.12.0-2.11.5-1.8-0.3-0.2-0.9
Progressive ratio test 2 active lever presses1.81.93.31.6-1.41.6-1.41.8-1.3-1.60.5-0.2
Progressive ratio test 2 breakpoint2.42.74.22.0-1.71.9-1.82.1-1.6-1.70.7-0.1
Progressive ratio test 2 inactive lever presses1.92.24.71.7-1.61.7-1.52.2-1.1-1.80.0-0.9
Incentive Sensitization - Responses0.90.93.50.4-0.20.7-0.21.2-0.8-1.91.00.9
Incentive Sensitization - Breakpoint1.01.03.80.4-0.20.8-0.21.2-0.9-2.01.21.0
Sum of active levers in priming session hrs 5-60.20.10.30.3-0.40.3-0.4-0.2-0.40.50.50.2
Progressive ratio0.80.92.1-1.41.1-0.91.0-0.10.5-1.40.60.7
Food seeking constrained by brief footshock3.64.47.12.3-2.42.7-2.41.9-2.3-0.62.21.4
Seeking ratio, punishment vs. effort2.32.85.92.4-2.22.2-2.11.2-1.70.90.70.2
Retroperitoneal fat weight0.72.14.11.4-1.41.9-1.51.20.11.0-1.7-2.0
Reaction time number correct0.50.82.4-0.81.0-1.51.1-0.70.7-0.6-0.50.0
Reaction time mean minus median0.10.10.4-0.20.2-0.20.2-0.30.60.3-0.5-0.4
Reaction time mean minus median AUC0.00.10.20.1-0.10.1-0.00.10.3-0.3-0.3-0.5
Reaction time num false alarms1.62.23.31.7-1.71.5-1.61.5-1.8-1.11.40.8
Reaction time num false alarms AUC2.23.04.62.1-2.01.8-2.01.9-1.9-1.21.50.6
Reaction time trials correct on left0.50.82.4-0.81.0-1.51.1-0.70.7-0.6-0.50.0
Reaction time trials on left0.50.72.1-0.70.9-1.51.1-0.60.7-0.7-0.5-0.0
Reaction time mean0.20.30.9-0.1-0.20.3-0.10.2-0.4-0.81.00.8
Reaction time mean AUC0.20.21.0-0.1-0.30.3-0.20.0-0.5-0.41.00.8
Median of all reaction times0.40.51.60.0-0.40.5-0.40.4-0.8-0.91.31.0
Reaction time omissions0.30.40.70.6-0.80.7-0.80.8-0.0-0.7-0.4-0.5
Reaction time false alarm rate2.33.34.72.1-2.12.2-2.11.7-2.1-0.51.70.8
Reaction time premature initiation rate0.30.30.80.6-0.40.8-0.60.6-0.00.3-0.6-0.9
Reaction time premature initiations0.10.20.80.20.10.00.00.20.4-0.0-0.8-0.9
Std. dev. reaction times0.20.30.60.3-0.40.5-0.40.5-0.4-0.80.70.7
Reaction time trials completed0.50.72.1-0.70.9-1.51.1-0.60.7-0.7-0.5-0.0
Reaction time trials AUC0.50.62.0-0.70.9-1.41.1-0.50.7-0.7-0.50.0
Run reversals in cocaine runway, females3.93.77.0-1.61.6-1.81.7-1.72.31.8-2.6-1.8
Run reversals in cocaine runway, males0.30.30.8-0.70.6-0.70.7-0.10.4-0.90.10.1
Latency to leave start box in cocaine runway0.50.51.5-0.70.7-0.70.7-1.20.10.90.00.6
Latency to leave start box in cocaine runway, F1.21.32.8-1.31.4-1.41.3-1.70.30.70.10.9
Latency to leave start box in cocaine runway, M0.10.10.30.2-0.30.4-0.2-0.10.10.6-0.3-0.1
Std. dev. time between licks in bursts0.91.12.1-0.70.7-0.60.8-0.71.41.1-1.4-1.4
Total sessions with >9 infusions0.80.93.10.0-0.1-0.0-0.1-0.30.51.1-1.7-1.8
Short access day 1 total inactive lever presses0.10.10.20.00.2-0.10.10.2-0.2-0.4-0.5-0.4
Short access day 10 total inactive lever presses0.30.30.80.5-0.60.9-0.50.8-0.4-0.6-0.1-0.2
Short access day 1 total infusions0.50.52.6-0.10.10.40.1-0.10.20.6-1.1-1.6
Short access day 10 total infusions3.03.35.32.3-2.32.0-2.21.8-0.80.3-1.3-2.2
Short access total infusions1.61.83.01.7-1.71.6-1.71.2-1.30.4-0.5-1.2
Short access day 1 locomotion2.02.18.41.1-1.01.0-1.01.00.30.7-2.2-2.9
Short access day 10 total locomotion3.94.310.22.5-2.43.2-2.32.6-1.3-0.3-0.5-1.7
Short access total locomotion2.72.86.91.8-1.71.8-1.71.4-0.51.0-1.7-2.6
One hour access (0.3 mA shock)2.22.65.21.9-1.92.3-2.01.4-1.8-0.41.10.3
Compulsive drug intake0.50.52.30.4-0.20.4-0.20.0-0.9-0.31.51.1
One hour access (shock baseline)0.70.81.51.1-1.21.1-1.20.9-0.5-0.0-0.3-0.7
Social response proportion0.20.20.50.7-0.70.4-0.60.4-0.5-0.20.3-0.0
Social responses1.41.84.42.1-1.81.5-1.71.0-1.40.40.4-0.6
Social time0.30.41.80.0-0.1-0.2-0.1-0.0-0.5-0.61.11.3
Soleus weight0.00.10.1-0.30.3-0.00.3-0.4-0.20.30.20.2
Bone: stiffness1.21.83.11.7-1.71.5-1.61.8-1.1-1.1-0.1-0.5
Tibialis anterior weight0.51.85.10.1-0.20.2-0.1-0.41.32.1-2.1-2.3
Time to tail flick, vehicle, before self-admin1.51.54.4-0.40.0-0.3-0.00.6-0.6-2.12.12.0
Time to tail flick, vehicle, after self-admin0.70.74.30.5-0.30.3-0.31.2-0.0-2.10.20.1
Time to tail flick, test, before self-admin0.80.81.30.9-1.00.8-1.00.8-0.8-0.71.10.9
Time to tail flick, test, after self-admin0.91.02.31.5-1.30.9-1.31.0-1.0-0.40.2-0.1
Delta time to tail flick, vehicle, before/after SA1.71.63.61.6-1.41.9-1.41.6-0.4-0.5-0.5-1.1
Delta time to tail flick, test, before/after SA0.20.21.00.3-0.30.1-0.30.6-0.6-1.00.20.3
Tibia length0.00.00.20.3-0.1-0.10.00.1-0.1-0.5-0.2-0.2
Ambulatory time before self-admin0.91.01.7-1.11.2-0.81.1-0.8-0.2-0.71.11.3
Ambulatory time after self-admin0.20.31.0-0.1-0.1-0.1-0.1-0.3-0.8-0.30.71.0
Bone: tissue strength1.00.91.8-1.31.3-1.31.2-1.10.60.0-0.20.3
Total heroin consumption0.60.71.50.8-0.60.7-0.70.5-1.2-0.71.20.8
Bone: trabecular number0.50.82.60.8-0.80.7-0.81.3-0.6-1.60.40.2
Bone: trabecular spacing0.20.30.7-0.40.4-0.50.5-0.80.10.80.30.3
Bone: trabecular thickness0.70.92.01.0-1.10.9-1.11.4-0.0-0.8-0.7-1.0
Bone: trabecular tissue density1.21.73.7-1.11.1-1.01.1-0.81.70.6-1.9-1.7
Water consumed over 24 hours0.60.72.30.3-0.30.5-0.4-0.10.61.4-1.2-1.5
Number of responses in last shaping day0.10.10.40.2-0.20.0-0.20.1-0.1-0.0-0.2-0.6