Hub : Genes

Cables1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Cables1 0.13 0.07 1.6e-04 -0 0.02 0.03 0 6.7e-01 1.2e-03 2.4e-04 8.2e-02
2 Brain intron excision ratio chr18_3151884_3157112 0.08 0.05 5.6e-06 0.06 0.04 0.06 0.06 2.0e-06 4.5e-05 4.8e-06 3.1e-06
3 Liver mRNA stability Cables1 0.05 0.03 1.9e-05 0.03 0.03 0.01 0.03 1.0e-04 5.6e-04 7.4e-03 1.1e-04
4 LHb mRNA stability Cables1 0.17 0.1 2.3e-03 0.01 0.06 0.04 0.07 1.7e-01 1.4e-02 3.6e-02 7.5e-03
5 Brain mRNA stability Cables1 0.05 0.03 1.9e-03 0.02 0.02 0.02 0.01 3.9e-03 5.8e-03 8.7e-03 1.4e-02
6 PL intron excision ratio chr18_3151884_3157112 0.05 0.03 5.7e-05 0.04 0.04 0.04 0.04 3.2e-05 3.0e-05 4.7e-05 3.4e-05
7 Brain gene expression Cables1 0.24 0.1 0.0e+00 0.25 0.26 0.26 0.26 3.9e-23 1.2e-23 9.3e-24 5.5e-24
8 NAcc gene expression Cables1 0.03 0.02 4.7e-03 0.02 0.02 0.02 0.02 1.7e-03 3.7e-03 2.6e-03 4.2e-03
9 BLA gene expression Cables1 0.18 0.1 2.5e-06 0.11 0.09 0.1 0.1 2.4e-06 1.9e-05 6.0e-06 2.9e-06
10 Adipose gene expression Cables1 0.04 0.03 5.6e-04 0.03 0.02 0.02 0.03 1.2e-04 1.4e-03 1.0e-03 3.0e-04
11 PL gene expression Cables1 0.1 0.05 1.8e-10 0.09 0.08 0.09 0.09 1.3e-09 3.6e-09 5.7e-10 1.2e-09
12 OFC gene expression Cables1 0.27 0.14 7.1e-04 0.15 0.13 0.08 0.12 2.3e-04 6.1e-04 6.6e-03 8.7e-04
13 IL gene expression Cables1 0.18 0.11 5.1e-03 0.12 0.09 0.12 0.12 7.9e-04 3.4e-03 9.1e-04 9.5e-04
14 NAcc intron excision ratio chr18_3151884_3157112 0.03 0.02 1.9e-03 0.01 0.02 0.01 0.01 5.8e-02 2.5e-03 3.7e-02 1.6e-02
15 pVTA mRNA stability Cables1 0.08 0.06 3.0e-03 0.02 0 0.02 0.01 3.2e-02 2.2e-01 3.9e-02 1.0e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.77.52.7-0.50.6-0.90.50.50.3-0.50.20.3-0.4-0.5-0.5-0.50.1
Area under the delay curve0.80.81.80.1-0.90.80.81.10.81.0-1.1-0.9-1.3-0.8-0.7-0.71.20.7
BMI with tail1.03.34.30.5-2.01.91.51.82.02.0-2.0-1.8-1.8-2.0-2.0-2.11.52.0
BMI without tail0.30.76.9-2.6-0.50.40.70.60.50.6-0.3-0.6-0.4-0.4-0.4-0.40.40.4
Body weight0.21.05.52.3-0.50.50.70.40.70.6-1.0-0.6-0.5-0.9-1.1-1.11.21.0
Weight adjusted by age1.11.39.83.10.7-0.6-1.3-0.9-0.8-0.90.51.00.90.70.50.5-0.9-0.5
Bone surface0.00.00.00.20.1-0.0-0.1-0.2-0.10.0-0.00.10.0-0.0-0.1-0.0-0.0-0.0
Bone volume0.10.21.11.10.2-0.1-0.9-0.2-0.2-0.20.20.60.60.30.10.2-0.6-0.4
Breakpoint value in progressive ratio session1.41.53.8-1.9-0.90.91.80.81.01.2-0.9-1.4-1.3-1.0-1.0-1.01.41.2
Number of licking bursts0.00.00.4-0.60.1-0.00.3-0.10.00.0-0.0-0.1-0.0-0.1-0.0-0.00.30.0
Context. condit. distance diff. score0.60.87.72.8-0.40.5-0.10.50.50.4-0.7-0.1-0.4-0.6-0.7-0.70.50.5
Locomotion velocity, session 10.30.40.7-0.8-0.50.60.80.60.70.6-0.6-0.8-0.1-0.7-0.6-0.60.40.4
Locomotion distance, session 11.21.66.1-0.2-0.40.42.40.40.60.7-1.2-1.5-0.5-1.3-1.3-1.32.51.3
Locomotion velocity, session 22.53.010.5-3.2-1.51.52.11.61.51.7-1.2-2.0-1.9-1.4-1.2-1.21.01.5
Locomotion distance, session 22.02.77.6-1.6-1.11.02.81.01.21.3-1.5-2.1-1.4-1.7-1.5-1.52.31.7
Locomotion velocity, session 31.21.43.8-0.2-0.60.71.90.60.80.9-1.2-1.5-0.8-1.2-1.2-1.22.01.3
Locomotion distance, session 32.22.34.70.4-0.91.02.10.91.21.2-1.7-1.8-1.7-1.6-1.7-1.72.21.8
Stereotopy head waving bouts, day 30.40.52.20.7-0.10.01.30.00.30.3-0.6-0.8-0.1-0.6-0.6-0.61.50.6
Stereotopy head waving duration, day 30.10.10.70.80.1-0.10.4-0.00.10.1-0.3-0.30.4-0.3-0.3-0.20.60.2
Locomotion velocity, session 70.30.31.01.00.6-0.7-0.4-0.6-0.6-0.50.50.60.90.40.40.3-0.0-0.5
Locomotion distance, session 70.10.21.11.10.4-0.5-0.1-0.5-0.4-0.50.20.40.40.20.10.10.2-0.0
Stereotopy head waving bouts, day 70.80.91.5-0.30.8-0.8-1.2-0.8-0.8-0.91.01.01.11.01.00.9-1.2-1.0
Stereotopy head waving duration, day 70.10.10.9-0.9-0.10.10.10.10.10.10.1-0.1-0.10.10.10.0-0.1-0.1
Locomotion velocity, session 81.01.21.8-0.8-1.01.11.31.01.11.2-1.1-1.3-1.0-1.2-1.0-1.01.20.8
Locomotion distance, session 80.60.94.30.7-0.20.11.70.20.40.4-1.0-1.0-0.5-1.0-1.0-1.02.11.0
Degree of sensitization distance2.82.84.50.31.3-1.5-2.1-1.3-1.6-1.61.82.11.91.81.81.8-1.9-1.8
Degree of sensitization stereotypy0.20.30.8-0.30.3-0.3-0.8-0.4-0.3-0.50.50.50.50.50.50.4-0.9-0.5
Conditioned locomotion1.61.83.7-0.31.1-1.0-1.8-1.0-1.0-1.21.41.41.61.41.41.4-1.9-1.6
Cocaine response after cond. corrected0.20.31.3-0.70.1-0.31.0-0.3-0.2-0.1-0.1-0.4-0.8-0.1-0.1-0.11.20.2
Cocaine response after cond. not corrected0.40.41.8-1.30.0-0.11.2-0.1-0.10.1-0.2-0.6-0.9-0.2-0.2-0.21.20.3
Cocaine response before conditioning0.50.61.5-1.2-0.91.00.70.90.91.0-0.5-0.8-0.4-0.6-0.5-0.50.30.7
Saline control response6.68.610.33.0-3.13.12.13.13.23.0-3.1-2.8-2.9-3.1-3.1-3.11.93.0
Bone: connectivity density0.40.62.11.5-0.91.0-0.20.90.80.8-0.7-0.4-0.4-0.6-0.7-0.7-0.30.5
Bone: cortical apparent density0.10.10.50.6-0.10.20.40.10.30.1-0.3-0.3-0.7-0.4-0.3-0.30.50.3
Bone: cortical area0.20.31.00.90.8-0.70.1-0.7-0.5-0.60.10.31.00.10.10.10.7-0.1
Bone: cortical porosity0.20.21.40.50.3-0.30.9-0.3-0.0-0.1-0.3-0.3-0.3-0.2-0.3-0.31.20.3
Bone: cortical porosity0.70.83.10.2-0.20.21.60.20.50.5-0.8-1.0-0.6-0.9-0.9-0.81.81.0
Bone: cortical thickness0.20.41.51.1-0.00.10.70.10.30.1-0.7-0.50.3-0.7-0.7-0.71.20.6
Bone: cortical thickness0.20.21.71.30.0-0.10.1-0.10.1-0.2-0.30.00.5-0.2-0.3-0.30.50.1
Bone: cortical tissue density0.10.10.50.5-0.10.10.40.10.20.1-0.2-0.3-0.7-0.3-0.2-0.20.50.3
Condit. Reinf. active minus inactive responses0.20.20.7-0.3-0.30.30.80.20.30.3-0.4-0.5-0.3-0.4-0.4-0.40.80.4
Condit. Reinf. active-inactive response ratio0.30.30.8-0.3-0.40.50.90.40.50.5-0.5-0.8-0.5-0.6-0.5-0.50.80.5
Condit. Reinf. active responses0.10.10.2-0.00.3-0.40.1-0.4-0.4-0.30.20.20.40.20.20.20.4-0.2
Condit. Reinf. inactive responses0.70.91.3-0.01.0-1.1-0.7-1.1-1.1-1.00.91.00.90.91.01.0-0.3-0.9
Incentive salience index mean0.10.10.5-0.40.1-0.10.6-0.2-0.2-0.0-0.1-0.20.3-0.1-0.1-0.10.70.1
Condit. Reinf. lever presses0.20.31.20.20.7-0.70.1-0.7-0.7-0.60.30.31.10.30.20.20.5-0.4
Condit. Reinf. active minus inactive responses1.21.52.1-1.41.0-1.0-1.2-1.0-1.2-1.01.41.21.21.41.41.4-1.3-1.4
Condit. Reinf. active-inactive response ratio3.33.55.1-2.31.6-1.7-1.6-1.6-1.9-1.72.11.81.62.12.12.1-1.7-2.0
Condit. Reinf. active responses0.10.20.4-0.00.3-0.3-0.6-0.4-0.3-0.30.40.40.50.50.40.4-0.5-0.5
Condit. Reinf. inactive responses3.13.86.52.6-1.81.91.41.82.11.9-2.2-1.8-1.7-2.1-2.2-2.21.62.0
Condit. Reinf. lever presses0.00.00.10.3-0.10.1-0.30.10.10.2-0.10.00.0-0.0-0.0-0.1-0.1-0.0
Condit. Reinf. lever reinforcers received0.10.10.40.10.2-0.1-0.6-0.2-0.2-0.10.30.40.40.40.40.3-0.5-0.5
Conditioned reinforcement - actives0.20.20.5-0.00.3-0.3-0.6-0.4-0.5-0.40.40.60.70.50.50.5-0.6-0.4
Conditioned reinforcement - inactives0.20.32.3-1.50.2-0.40.2-0.1-0.5-0.50.50.30.10.40.40.4-0.2-0.3
Conditioned locomotion0.50.60.80.2-0.80.90.80.90.80.8-0.8-0.8-0.9-0.8-0.7-0.70.60.8
Patch foraging indifference point 0 sec3.14.96.90.4-2.52.61.82.42.52.6-2.2-2.3-2.6-2.3-2.2-2.21.32.2
Patch foraging indifference point AUC0.10.10.60.0-0.40.4-0.50.30.30.30.10.0-0.30.0-0.0-0.0-0.80.2
Delay disc. indifference point, 0s delay0.30.31.2-1.0-0.30.10.90.40.20.5-0.4-0.6-0.6-0.4-0.4-0.41.10.5
Delay disc. indifference point, 16s delay0.20.20.7-0.3-0.20.10.50.30.10.3-0.3-0.5-0.6-0.2-0.3-0.30.80.2
Delay disc. indifference point, 2s delay1.01.15.2-2.3-1.10.91.11.30.81.2-0.8-0.8-1.5-0.7-0.3-0.40.80.3
Delay disc. indifference point, 24s delay0.50.53.7-1.9-0.60.50.40.70.30.6-0.1-0.9-0.6-0.1-0.1-0.10.40.1
Delay disc. indifference point, 4s delay0.30.31.00.5-0.40.30.60.50.40.5-0.8-0.2-1.0-0.5-0.5-0.50.90.6
Delay disc. indifference point, 8s delay1.81.83.11.8-1.31.30.91.31.31.3-1.6-1.3-1.5-1.4-1.3-1.21.41.2
Indifference point function ln k0.50.73.82.0-0.30.50.60.30.60.5-1.0-0.6-0.5-0.9-0.9-0.90.80.7
Indifference point function log k0.50.73.82.0-0.30.50.60.30.60.5-1.0-0.6-0.5-0.9-0.9-0.90.80.7
Patch foraging total patch changes 0 sec3.45.47.60.4-2.62.72.02.52.62.8-2.3-2.4-2.7-2.4-2.3-2.31.52.4
Patch foraging total patch changes 12 sec0.20.20.9-0.6-0.60.50.10.50.50.6-0.1-0.5-1.0-0.2-0.2-0.1-0.20.4
Patch foraging total patch changes 18 sec2.93.86.01.2-2.42.31.32.42.12.3-1.8-1.9-2.2-1.9-1.8-1.81.11.9
Patch foraging total patch changes 24 sec0.40.41.4-0.4-1.10.9-0.61.00.70.8-0.1-0.1-0.7-0.1-0.1-0.1-1.20.2
Patch foraging total patch changes 6 sec4.77.09.11.3-2.93.02.12.93.03.0-2.5-2.7-3.0-2.7-2.6-2.61.72.7
Patch foraging time to switch 0 sec0.30.53.4-1.90.5-0.50.6-0.4-0.6-0.40.50.10.60.40.50.50.7-0.5
Patch foraging water rate 0 sec0.71.15.52.3-0.50.70.70.40.80.7-1.1-0.6-1.2-1.0-1.2-1.10.81.2
Patch foraging water rate 12 sec2.33.64.90.8-2.02.01.51.92.22.0-2.2-1.9-1.6-2.1-2.1-2.21.31.9
Patch foraging water rate 18 sec1.92.53.30.9-1.71.71.11.71.81.7-1.8-1.5-1.5-1.7-1.8-1.80.91.8
Patch foraging water rate 24 sec0.81.13.31.8-0.71.00.60.81.00.9-1.2-0.8-1.0-1.0-1.3-1.21.01.1
Patch foraging water rate 6 sec1.31.82.81.3-1.00.91.50.81.11.1-1.5-1.2-1.6-1.4-1.6-1.61.71.6
Seeking ratio, delayed vs. immediate footshock1.01.215.23.90.20.2-0.9-0.3-0.1-0.2-0.00.80.20.10.20.2-0.4-0.4
Distance traveled before self-admin2.62.83.61.2-1.91.81.11.71.81.8-1.7-1.5-1.8-1.7-1.8-1.81.11.8
Distance traveled after self-admin0.70.81.5-1.20.8-0.8-0.7-0.9-0.8-0.81.01.00.61.00.90.9-0.7-1.1
Extensor digitorum longus weight3.011.715.11.9-3.03.13.93.03.53.4-3.7-3.7-3.1-3.7-3.7-3.73.83.5
Bone: elastic displacement0.00.00.0-0.2-0.1-0.00.10.00.00.1-0.1-0.00.1-0.1-0.1-0.10.20.1
Bone: elastic work0.81.04.42.1-1.11.0-0.01.11.11.0-1.1-0.50.1-1.0-1.1-1.10.40.8
Bone: endosteal estimation0.20.51.2-0.41.1-1.00.2-1.1-0.8-0.60.60.40.60.60.60.60.4-0.5
Bone: endosteal perimeter0.40.81.7-1.31.1-0.9-0.4-1.0-0.9-0.80.90.70.90.90.80.9-0.3-0.9
Epididymis fat weight0.41.02.5-0.10.6-0.8-1.6-0.7-0.8-0.90.91.31.01.00.90.9-1.4-1.1
Delta time in closed arm before/after self-admin0.50.51.61.3-0.70.70.40.50.80.7-0.8-0.8-0.4-0.8-0.6-0.60.40.6
Delta time in open arm before/after self-admin0.20.21.3-1.1-0.50.4-0.00.30.20.4-0.0-0.1-0.4-0.1-0.2-0.2-0.40.2
Diff in mean of infusions in LGA sessions0.10.11.21.1-0.10.1-0.50.10.20.1-0.10.00.1-0.1-0.2-0.2-0.50.3
Delay discount exponential model param0.60.61.50.30.8-0.7-0.7-1.0-0.7-0.90.90.71.20.70.50.5-1.1-0.4
Extinction: sum of active levers before priming0.80.82.0-1.4-0.50.51.30.40.70.7-0.6-1.1-0.8-0.8-0.7-0.81.20.8
Active lever presses in extinction session 61.71.69.1-3.01.2-1.30.0-1.3-1.2-1.01.20.71.11.11.11.10.0-1.1
Bone: final force0.20.33.31.80.3-0.3-0.2-0.3-0.1-0.2-0.30.30.6-0.2-0.3-0.30.50.0
Bone: final moment0.20.43.11.80.6-0.5-0.0-0.6-0.3-0.4-0.20.30.7-0.1-0.2-0.20.8-0.1
Food consumed during 24 hour testing period0.40.53.40.80.5-0.41.4-0.5-0.2-0.1-0.5-0.40.3-0.4-0.5-0.51.80.5
Glucose0.00.00.2-0.1-0.20.3-0.10.20.10.10.0-0.0-0.50.10.00.0-0.40.1
Heart weight0.20.30.70.9-0.20.40.70.10.40.5-0.7-0.6-0.4-0.6-0.7-0.70.80.6
Delay discount hyperbolic model param0.50.51.50.40.7-0.6-0.7-0.9-0.6-0.80.80.61.20.60.40.4-1.0-0.4
Intermittent access intake day 1-15 change1.01.07.22.7-1.30.9-0.41.00.80.8-0.7-0.3-0.4-0.6-0.6-0.6-0.50.5
Intermittent access intake escalation0.40.43.61.9-0.70.3-0.50.50.40.3-0.20.0-0.1-0.2-0.1-0.0-0.7-0.0
Intermittent access intake escalation 20.40.42.71.6-0.4-0.1-0.80.2-0.1-0.20.20.50.30.30.40.5-1.0-0.6
Intermitt. access day 1 inactive lever presses1.21.31.80.9-1.31.30.81.11.21.0-1.3-1.1-1.3-1.3-1.2-1.30.61.2
Intermitt. access day 15 inactive lever presses1.61.815.74.0-1.11.3-0.21.11.10.7-1.1-0.4-0.7-1.0-1.0-1.0-0.30.8
Intermitt. access escalation Index0.20.20.80.40.9-0.5-0.2-0.9-0.4-0.50.30.50.30.30.20.2-0.0-0.4
Intermittent access day 1 total infusions0.70.82.5-1.61.1-0.9-0.3-1.0-1.0-0.91.00.70.70.90.90.9-0.5-0.7
Intermittent access day 15 total infusions0.50.60.9-0.10.5-0.7-0.7-0.6-0.8-0.70.90.70.90.80.90.9-0.8-0.9
Intermittent access terminal intake (last 3 days)0.91.01.70.40.5-0.9-1.1-0.6-1.0-0.91.01.11.31.01.11.1-1.1-1.1
Intermittent access total infusions1.01.11.5-0.41.0-1.2-0.9-0.9-1.2-1.11.21.21.11.11.11.2-0.9-1.1
Intermittent access day 1 locomotion0.20.21.5-1.20.4-0.00.8-0.3-0.1-0.0-0.1-0.3-0.2-0.1-0.1-0.10.60.2
Intermittent access day 15 total locomotion0.10.10.4-0.5-0.00.00.60.0-0.00.2-0.1-0.40.1-0.10.10.00.6-0.0
Intermittent access total locomotion0.00.00.0-0.20.1-0.00.20.0-0.10.0-0.1-0.00.0-0.10.10.00.1-0.1
Intermittent access standard deviation1.01.14.62.1-0.0-0.4-1.70.3-0.5-0.60.61.11.10.80.90.8-1.5-1.0
Left kidney weight0.10.32.71.60.3-0.40.4-0.7-0.3-0.2-0.10.30.4-0.1-0.1-0.10.8-0.0
Right kidney weight0.10.33.31.80.1-0.2-0.1-0.4-0.2-0.1-0.10.30.3-0.0-0.0-0.10.2-0.0
Cocaine induced anxiety1.01.213.0-3.60.7-0.71.1-0.4-0.6-0.40.5-0.2-0.20.40.40.30.9-0.6
Post-drug Anxiety5.56.113.5-3.72.7-2.8-1.1-2.5-2.7-2.62.62.12.22.52.42.4-1.0-2.5
Baseline Anxiety1.71.85.82.40.9-0.8-2.0-1.0-0.9-1.11.01.71.41.11.11.1-1.8-0.9
Tail length0.30.92.7-1.61.0-1.2-0.1-1.0-1.0-0.91.00.61.20.91.00.9-0.1-0.9
Length with tail0.51.76.32.51.6-1.6-0.5-1.7-1.3-1.40.81.11.30.90.90.80.1-0.9
Length without tail1.02.129.75.50.5-0.4-0.5-0.7-0.2-0.4-0.40.50.3-0.1-0.3-0.40.30.1
Times rat made contact with spout0.10.11.8-1.30.2-0.20.2-0.3-0.1-0.10.1-0.00.30.10.10.10.1-0.1
Lifetime Intake1.31.41.8-0.91.2-1.3-0.8-1.1-1.4-1.31.31.21.21.21.31.3-0.9-1.3
Liver weight, left0.91.42.10.31.2-1.1-1.5-1.1-1.1-1.21.21.30.91.31.21.2-1.2-1.2
Liver weight, right0.81.43.30.00.9-0.9-1.8-1.0-1.0-1.01.21.40.71.21.21.2-1.7-1.2
Locomotor activity0.20.40.60.6-0.70.7-0.00.80.70.8-0.7-0.50.3-0.6-0.6-0.70.10.4
Locomotor testing distance1.32.13.61.0-1.91.90.61.91.71.8-1.5-1.3-1.0-1.5-1.5-1.50.51.4
Locomotor testing rearing1.62.54.41.5-2.12.10.32.11.91.8-1.6-1.2-1.1-1.6-1.6-1.70.31.5
Locomotion in novel chamber0.40.51.10.41.0-0.8-0.3-1.1-0.7-1.00.70.80.40.70.40.4-0.7-0.3
Locomotion in novel chamber post-restriction0.20.20.6-0.0-0.70.40.40.80.50.4-0.4-0.4-0.1-0.3-0.3-0.30.40.3
Fecal boli incidents, locomotor time 10.60.71.0-0.7-0.90.61.00.90.80.9-0.7-0.6-0.9-0.7-0.8-0.80.90.7
Change in fecal boli incidents, locomotor task2.01.99.8-3.11.4-1.2-0.3-1.4-1.4-1.21.50.70.71.41.31.3-0.4-1.3
Time >=10cm from walls, locomotor time 11.91.94.21.21.2-1.0-2.0-1.3-1.1-1.41.11.81.51.21.21.2-1.7-1.3
Bouts of movement, locomotor time 10.70.71.7-0.30.8-1.0-0.8-1.3-1.0-0.90.91.10.80.90.60.6-0.5-0.6
Total resting periods, locomotor time 10.40.41.1-0.40.6-0.8-0.6-1.1-0.8-0.70.70.90.50.70.40.4-0.4-0.4
Rest time, locomotor task time 10.10.11.9-1.4-0.2-0.00.3-0.10.00.10.1-0.00.0-0.0-0.1-0.10.20.2
Distance moved, locomotor task time 10.91.02.51.60.7-0.6-1.6-0.7-0.7-0.90.61.40.70.80.90.9-1.4-0.9
Vertical activity count, locomotor time 10.91.08.83.00.1-0.0-1.6-0.2-0.1-0.40.01.10.30.20.30.3-1.1-0.4
Time >=10cm from walls, locomotor time 20.30.30.90.90.4-0.6-0.5-0.5-0.5-0.50.30.80.80.40.50.5-0.3-0.6
Bouts of movement, locomotor time 21.21.32.2-1.50.9-0.9-1.0-1.0-1.1-1.01.21.10.71.21.31.3-1.1-1.3
Total resting periods, locomotor time 21.21.22.6-1.60.8-1.0-0.9-1.0-1.1-1.01.21.00.61.21.31.3-1.1-1.2
Rest time, locomotor task time 20.70.810.3-3.20.2-0.50.8-0.5-0.4-0.20.6-0.30.20.40.20.20.1-0.2
Distance moved, locomotor task time 21.21.417.64.20.00.1-1.20.00.1-0.2-0.40.90.1-0.10.20.2-0.6-0.1
Vertical activity count, locomotor time 21.61.716.84.1-0.91.0-0.70.91.00.7-1.30.1-0.6-1.0-0.6-0.60.20.6
Light reinforcement 10.10.10.60.6-0.10.0-0.80.3-0.1-0.00.30.30.10.30.20.2-0.8-0.1
Light reinforcement 20.71.01.5-0.50.6-1.0-1.0-0.3-1.1-0.91.21.10.81.21.21.2-0.9-1.1
Bone: marrow area0.20.41.1-0.51.1-1.00.2-1.1-0.8-0.60.60.40.50.50.50.60.5-0.4
Bone: maximum diameter0.10.20.8-0.90.6-0.40.1-0.5-0.3-0.30.30.20.50.30.30.30.2-0.3
Bone: maximum force0.20.42.31.50.7-0.6-0.6-0.7-0.5-0.60.10.61.00.20.10.10.1-0.4
Bone: maximum moment0.30.62.21.51.0-0.9-0.3-1.0-0.7-0.80.20.61.20.30.20.20.5-0.5
Mean time between licks in bursts2.63.76.2-2.52.0-2.1-1.3-2.0-1.9-1.92.01.71.81.92.02.0-1.3-1.9
Mean num. licks in bursts0.00.00.10.2-0.20.2-0.30.20.20.1-0.1-0.00.1-0.1-0.1-0.1-0.40.2
Cd content in liver0.20.21.9-1.4-0.10.1-0.20.10.10.00.20.1-0.40.20.20.2-0.6-0.1
Co content in liver2.93.45.8-2.41.5-1.6-1.7-1.5-1.7-1.72.01.81.42.02.12.1-2.0-2.0
Cu content in liver0.30.31.00.80.3-0.4-0.9-0.3-0.5-0.50.30.81.00.40.30.3-0.5-0.5
Fe content in liver1.21.42.31.2-1.51.50.51.51.41.3-1.2-1.0-1.0-1.2-1.2-1.20.21.1
K content in liver6.26.17.2-1.72.6-2.6-2.1-2.6-2.7-2.62.62.62.42.62.62.6-1.9-2.6
Mg content in liver13.613.916.7-2.03.8-3.8-3.5-3.8-3.8-3.83.93.94.03.93.93.9-3.2-4.1
Mn content in liver0.91.02.10.21.4-1.4-0.4-1.4-1.2-1.30.90.91.20.90.90.90.0-0.9
Na content in liver1.11.11.70.41.0-1.1-1.2-1.1-1.2-1.20.91.31.21.01.01.0-0.9-1.1
Rb content in liver0.10.10.70.2-0.00.00.80.10.20.1-0.3-0.40.0-0.4-0.2-0.20.80.2
Se content in liver0.70.91.2-0.11.0-1.1-0.8-1.1-1.1-1.11.01.00.81.01.01.0-0.6-1.0
Sr content in liver0.20.22.7-1.60.2-0.2-0.1-0.2-0.3-0.20.30.10.10.20.30.3-0.2-0.2
Zn content in liver3.33.66.8-2.61.5-1.6-2.1-1.5-1.7-1.72.01.81.62.02.02.0-2.2-2.0
Bone: minimum diameter0.51.02.20.31.5-1.3-0.3-1.4-1.1-1.10.80.91.50.80.80.80.3-0.8
Time in familiar zone, hab. session 10.30.31.41.2-0.60.5-1.00.60.30.2-0.00.4-0.40.1-0.1-0.1-0.90.1
Time in novel zone, hab. session 10.30.32.5-1.60.4-0.40.8-0.5-0.2-0.30.1-0.30.30.00.10.20.6-0.2
Total zone transitions, hab. session 10.50.72.80.8-0.30.31.40.30.40.5-0.9-0.9-0.3-0.9-0.9-0.91.71.0
Total locomotion distance, hab. session 10.30.51.11.00.8-0.90.1-0.8-0.8-0.80.30.51.10.30.30.30.7-0.4
Locomotion velocity, hab. session 10.71.02.30.91.3-1.3-0.1-1.3-1.2-1.10.70.81.50.70.70.70.6-0.7
Time in familiar zone, hab. session 22.02.112.63.6-1.51.6-0.51.61.41.2-1.3-0.5-0.9-1.1-1.3-1.3-0.21.0
Time in novel zone, hab. session 21.11.111.1-3.30.8-0.81.0-0.9-0.6-0.40.6-0.2-0.00.40.60.60.6-0.3
Total zone transitions, hab. session 21.51.96.3-0.4-0.80.72.50.80.91.0-1.2-1.7-1.0-1.3-1.2-1.32.51.4
Total locomotion distance, hab. session 20.91.25.00.7-0.50.51.90.50.60.6-1.0-1.2-0.5-1.0-1.0-1.02.21.1
Locomotion velocity, hab. session 20.40.63.30.7-0.20.01.40.20.20.2-0.6-0.7-0.1-0.6-0.6-0.61.80.7
Novel to familiar place preference ratio0.30.33.4-1.90.1-0.30.2-0.2-0.3-0.10.40.10.30.30.30.3-0.1-0.1
Novelty place preference0.40.43.8-1.90.3-0.50.1-0.4-0.4-0.30.50.20.50.40.40.4-0.2-0.3
Time in novel zone, NPP test0.20.22.8-1.7-0.20.00.60.10.10.2-0.0-0.40.0-0.1-0.1-0.10.30.3
Total zone transitions, NPP test2.63.77.70.2-1.31.42.81.41.61.7-2.1-2.3-1.6-2.1-2.0-2.02.82.1
Total locomotion distance, NPP test0.40.63.01.10.1-0.11.3-0.10.10.1-0.7-0.6-0.0-0.7-0.7-0.71.70.7
Locomotion velocity, NPP test0.30.42.00.90.1-0.11.0-0.10.00.0-0.5-0.5-0.1-0.5-0.5-0.51.40.6
Intraocular pressure0.71.01.80.2-1.31.30.41.31.31.1-1.2-1.0-0.9-1.1-1.0-1.00.10.9
Delta distance traveled before/after self-admin4.95.36.4-2.32.5-2.4-1.6-2.4-2.5-2.32.52.12.22.42.52.5-1.6-2.5
Delta ambulatory time before/after self-admin4.75.26.2-2.22.5-2.5-1.6-2.4-2.5-2.42.52.02.12.42.42.4-1.6-2.5
Parametrial fat weight0.40.72.51.61.4-1.0-0.4-1.5-0.7-0.90.30.80.40.40.40.30.3-0.2
Pavlov. Cond. lever latency0.20.20.9-1.00.4-0.50.3-0.4-0.5-0.40.50.20.30.50.50.50.3-0.5
Pavlov. Cond. magazine entry latency0.30.41.11.00.7-0.6-0.5-0.7-0.6-0.60.30.51.10.40.30.3-0.1-0.4
Pavlov. Cond. change in total contacts0.10.10.40.50.5-0.50.1-0.6-0.4-0.30.00.10.50.00.00.10.4-0.1
Pavlov. Cond. index score0.30.41.71.30.7-0.6-0.7-0.8-0.6-0.60.30.61.00.40.30.3-0.2-0.4
Pavlov. Cond. latency score0.20.21.01.00.5-0.4-0.5-0.5-0.3-0.40.10.40.70.20.10.1-0.2-0.3
Pavlov. Cond. lever contacts0.10.11.11.10.1-0.0-0.5-0.20.0-0.1-0.20.10.3-0.1-0.1-0.1-0.20.1
Pavlov. Cond. magazine entry number1.11.32.8-0.8-1.31.31.21.31.21.2-0.9-1.2-1.7-1.0-0.9-0.90.71.1
Pavlov. Cond. intertrial magazine entries0.10.10.9-1.00.3-0.30.0-0.3-0.3-0.30.30.20.40.30.30.30.0-0.3
Pavlov. Cond. lever-magazine prob. diff.0.40.52.21.50.8-0.7-0.6-0.8-0.6-0.60.20.60.90.30.20.3-0.1-0.4
Pavlov. Cond. response bias0.81.02.11.01.1-1.0-1.1-1.1-1.0-1.00.71.11.40.80.70.8-0.7-0.9
Pavlov. Cond. lever latency0.10.10.8-0.90.4-0.4-0.0-0.4-0.3-0.30.30.10.30.30.30.3-0.3-0.2
Pavlov. Cond. magazine entry latency0.20.30.4-0.20.5-0.6-0.2-0.6-0.6-0.50.50.60.60.50.50.50.2-0.5
Pavlov. Cond. change in total contacts0.30.32.51.6-0.50.4-0.00.40.50.4-0.6-0.3-0.0-0.5-0.6-0.60.50.3
Pavlov. Cond. index score0.00.00.10.40.0-0.1-0.1-0.0-0.1-0.10.00.20.00.10.00.00.2-0.1
Pavlov. Cond. latency score0.00.00.30.60.1-0.1-0.3-0.1-0.2-0.10.10.30.20.10.10.10.1-0.2
Pavlov. Cond. lever contacts0.00.10.30.6-0.10.10.20.10.10.1-0.2-0.1-0.0-0.2-0.2-0.20.60.1
Pavlov. Cond. magazine entry number0.00.10.40.3-0.20.2-0.30.20.20.10.00.0-0.20.00.00.0-0.60.0
Pavlov. Cond. intertrial magazine entries0.60.83.0-0.20.5-0.4-1.4-0.4-0.6-0.60.91.00.80.90.90.9-1.7-1.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.20.0-0.10.0-0.0-0.1-0.0-0.00.1-0.00.00.0-0.00.3-0.1
Pavlov. Cond. response bias0.00.00.4-0.20.1-0.20.3-0.2-0.1-0.0-0.0-0.10.0-0.00.0-0.00.7-0.0
Time in closed arm before self-admin2.12.43.4-0.31.8-1.7-1.5-1.5-1.7-1.81.61.81.31.61.51.5-1.2-1.5
Time in closed arm after self-admin0.30.30.70.00.9-0.8-0.3-0.6-0.6-0.70.50.30.40.50.60.6-0.2-0.6
Time in open arm before self-admin0.80.94.32.1-0.90.90.00.90.90.9-1.0-0.7-0.2-0.8-0.9-0.80.40.8
Time in open arm after self-admin0.10.10.4-0.3-0.70.6-0.20.30.40.5-0.2-0.1-0.1-0.2-0.2-0.2-0.30.2
Bone: periosteal estimation0.30.71.9-0.11.4-1.20.2-1.3-1.0-0.90.60.51.10.60.60.60.7-0.5
Bone: periosteal perimeter0.30.51.2-0.60.9-0.8-0.3-0.9-0.7-0.70.60.61.10.60.60.60.0-0.7
Bone: post-yield work0.91.21.6-0.61.2-1.2-1.1-1.2-1.3-1.21.11.30.61.21.11.1-1.0-1.1
Progressive ratio test 1 active lever presses0.10.10.91.00.3-0.2-0.4-0.3-0.2-0.40.20.40.20.20.20.1-0.4-0.1
Progressive ratio test 1 breakpoint0.10.10.60.80.3-0.1-0.3-0.3-0.2-0.30.20.30.30.10.20.1-0.3-0.1
Progressive ratio test 1 inactive lever presses0.50.52.0-1.4-0.30.41.20.30.40.4-0.5-0.8-0.9-0.6-0.6-0.60.90.6
Progressive ratio test 2 active lever presses1.21.31.7-0.21.3-1.3-0.9-1.3-1.3-1.31.21.21.21.21.21.2-0.9-1.1
Progressive ratio test 2 breakpoint0.60.70.80.10.9-0.9-0.7-0.9-0.9-0.90.80.90.80.90.80.9-0.7-0.7
Progressive ratio test 2 inactive lever presses2.73.14.20.41.8-1.8-1.6-1.8-1.9-2.01.72.11.91.81.81.8-1.5-1.7
Incentive Sensitization - Responses1.51.52.21.01.1-1.2-1.5-1.2-1.2-1.21.11.41.31.31.11.2-1.3-1.0
Incentive Sensitization - Breakpoint1.01.01.51.10.9-1.0-1.2-1.0-1.0-1.00.91.21.01.10.91.0-1.1-0.8
Sum of active levers in priming session hrs 5-61.11.16.0-2.5-0.50.51.70.50.60.8-0.5-1.1-1.0-0.7-0.5-0.51.30.5
Progressive ratio0.50.63.31.8-0.91.1-0.90.70.80.7-0.50.0-0.4-0.5-0.4-0.4-0.70.2
Food seeking constrained by brief footshock0.40.51.00.30.5-0.6-1.0-0.5-0.7-0.70.80.80.70.70.80.8-0.8-1.0
Seeking ratio, punishment vs. effort0.70.94.0-2.01.1-1.30.4-1.0-1.1-0.90.90.40.60.80.80.80.2-0.7
Retroperitoneal fat weight0.10.20.40.70.3-0.5-0.4-0.5-0.5-0.40.40.40.50.40.40.3-0.1-0.4
Reaction time number correct0.20.31.51.2-0.70.6-0.60.70.50.5-0.40.0-0.5-0.2-0.4-0.3-0.80.3
Reaction time mean minus median0.70.92.2-1.51.2-1.00.5-1.2-1.0-0.90.90.61.00.80.90.90.8-0.9
Reaction time mean minus median AUC1.52.05.0-2.21.7-1.40.1-1.6-1.5-1.31.51.01.71.31.41.40.5-1.4
Reaction time num false alarms2.12.94.2-1.22.0-2.0-0.9-2.0-1.9-2.01.91.61.21.81.91.9-0.7-1.5
Reaction time num false alarms AUC2.63.64.7-1.62.2-2.1-1.1-2.1-2.0-2.12.21.81.32.12.12.1-1.0-1.7
Reaction time trials correct on left0.20.31.51.2-0.70.6-0.60.70.50.5-0.40.0-0.5-0.2-0.4-0.3-0.80.3
Reaction time trials on left0.20.31.51.2-0.60.6-0.60.70.50.4-0.30.0-0.5-0.2-0.4-0.3-0.80.3
Reaction time mean0.60.81.6-1.01.2-1.00.9-1.2-1.0-0.80.60.41.30.50.60.61.2-0.6
Reaction time mean AUC0.50.71.6-0.81.2-0.90.8-1.1-1.0-0.80.50.41.30.50.60.51.2-0.6
Median of all reaction times0.40.61.3-0.61.0-0.90.8-1.0-0.9-0.70.40.31.20.40.40.41.1-0.4
Reaction time omissions0.30.41.30.30.9-0.80.7-0.9-0.7-0.60.40.20.80.40.50.41.1-0.4
Reaction time false alarm rate2.43.35.0-1.72.2-2.2-0.8-2.2-2.0-2.12.01.61.41.92.02.0-0.5-1.6
Reaction time premature initiation rate3.54.76.6-0.9-2.42.52.02.12.32.5-2.2-2.6-2.2-2.3-2.3-2.31.32.1
Reaction time premature initiations2.94.16.4-0.3-2.42.51.42.22.32.4-2.0-2.2-2.2-2.1-2.1-2.10.51.9
Std. dev. reaction times1.11.65.1-2.31.6-1.20.5-1.5-1.3-1.11.20.71.51.01.11.10.8-1.2
Reaction time trials completed0.20.31.51.2-0.60.6-0.60.70.50.4-0.30.0-0.5-0.2-0.4-0.3-0.80.3
Reaction time trials AUC0.20.31.61.3-0.50.5-0.70.50.40.3-0.20.2-0.4-0.1-0.3-0.2-0.90.2
Run reversals in cocaine runway, females0.20.20.60.5-0.80.40.10.70.30.5-0.2-0.2-0.1-0.3-0.2-0.20.30.3
Run reversals in cocaine runway, males0.30.33.41.80.3-0.30.2-0.2-0.1-0.2-0.30.10.3-0.1-0.2-0.20.50.1
Latency to leave start box in cocaine runway1.01.12.7-1.2-0.60.81.40.60.80.9-1.1-1.3-1.3-1.0-0.9-0.91.60.9
Latency to leave start box in cocaine runway, F1.51.63.50.1-1.11.21.71.01.11.3-1.3-1.4-1.6-1.3-1.2-1.21.91.1
Latency to leave start box in cocaine runway, M0.40.41.10.2-0.10.40.70.30.60.4-0.8-0.9-0.4-0.8-0.8-0.81.10.7
Std. dev. time between licks in bursts1.01.22.3-1.51.5-1.5-0.1-1.5-1.3-1.31.00.80.91.01.01.00.1-0.9
Total sessions with >9 infusions0.20.21.5-1.20.3-0.4-0.1-0.2-0.4-0.40.40.30.30.30.50.4-0.4-0.3
Short access day 1 total inactive lever presses0.91.012.2-3.50.4-0.50.6-0.5-0.5-0.30.60.00.20.40.60.40.1-0.4
Short access day 10 total inactive lever presses0.20.30.5-0.5-0.70.70.40.70.40.3-0.6-0.5-0.3-0.5-0.5-0.50.20.5
Short access day 1 total infusions0.91.01.6-0.60.9-1.1-0.8-1.0-1.0-1.01.01.11.31.01.11.0-0.9-1.0
Short access day 10 total infusions0.20.30.4-0.60.6-0.6-0.2-0.4-0.6-0.60.50.60.50.50.60.5-0.4-0.5
Short access total infusions1.71.92.4-1.61.4-1.5-0.8-1.3-1.5-1.41.51.31.51.41.51.4-1.0-1.4
Short access day 1 locomotion0.40.53.7-1.9-0.50.31.10.50.30.4-0.2-0.8-0.2-0.4-0.1-0.20.80.2
Short access day 10 total locomotion0.91.01.61.3-0.91.10.61.21.01.1-1.2-0.8-0.7-1.1-0.9-1.00.50.9
Short access total locomotion0.10.11.1-1.10.1-0.10.30.1-0.1-0.10.0-0.10.3-0.00.20.10.1-0.2
One hour access (0.3 mA shock)0.81.01.61.00.8-0.6-1.2-1.0-0.9-0.90.91.01.10.91.11.1-1.3-0.9
Compulsive drug intake0.00.00.10.20.20.2-0.2-0.20.10.1-0.1-0.00.0-0.00.0-0.1-0.20.1
One hour access (shock baseline)1.11.31.91.00.7-1.0-1.4-0.7-1.1-1.11.11.31.31.11.21.3-1.2-1.2
Social response proportion1.92.16.8-2.61.3-1.2-1.4-1.2-1.2-1.11.51.10.81.41.61.5-1.6-1.5
Social responses0.10.10.3-0.5-0.30.40.10.40.40.4-0.2-0.3-0.3-0.3-0.1-0.2-0.10.1
Social time4.76.27.60.7-2.42.62.32.52.72.6-2.7-2.7-2.4-2.7-2.7-2.71.92.7
Soleus weight2.16.27.21.4-2.62.62.32.62.62.6-2.7-2.6-2.4-2.7-2.7-2.72.12.6
Bone: stiffness0.30.45.02.20.2-0.00.1-0.10.1-0.0-0.5-0.00.2-0.4-0.5-0.50.80.3
Tibialis anterior weight2.79.411.42.0-2.72.83.42.73.03.1-3.2-3.3-3.2-3.3-3.2-3.23.33.1
Time to tail flick, vehicle, before self-admin0.80.89.63.1-0.1-0.0-1.3-0.1-0.0-0.2-0.20.50.5-0.0-0.2-0.2-0.80.1
Time to tail flick, vehicle, after self-admin0.20.20.90.9-0.0-0.1-0.7-0.1-0.2-0.20.10.41.00.10.20.2-0.6-0.4
Time to tail flick, test, before self-admin2.32.211.23.31.1-1.2-2.0-0.9-1.1-1.40.91.71.51.11.01.0-1.3-0.9
Time to tail flick, test, after self-admin2.02.07.82.81.4-1.4-1.5-1.4-1.2-1.50.91.41.71.10.80.9-1.2-1.0
Delta time to tail flick, vehicle, before/after SA0.20.21.2-1.1-0.40.50.60.40.40.5-0.2-0.4-0.1-0.3-0.00.00.2-0.0
Delta time to tail flick, test, before/after SA0.10.10.80.90.2-0.1-0.0-0.5-0.1-0.2-0.00.00.3-0.0-0.2-0.1-0.20.0
Tibia length1.33.58.00.12.7-2.6-0.3-2.8-2.3-2.41.51.62.41.51.51.40.6-1.6
Ambulatory time before self-admin0.90.91.5-0.6-1.01.01.10.91.01.1-0.9-0.9-1.2-0.9-1.0-0.91.00.9
Ambulatory time after self-admin1.01.14.7-2.21.0-1.0-0.3-1.1-1.0-0.91.20.80.61.01.01.0-0.3-1.1
Bone: tissue strength0.60.61.2-0.11.0-1.0-0.3-1.0-0.9-0.80.60.71.10.60.60.60.1-0.8
Total heroin consumption0.50.61.00.3-1.01.00.60.71.01.0-0.8-0.9-0.7-0.8-0.7-0.70.20.6
Bone: trabecular number0.50.86.32.5-0.80.9-0.90.80.70.6-0.60.00.2-0.5-0.7-0.6-0.70.3
Bone: trabecular spacing0.70.92.1-0.71.4-1.50.1-1.3-1.2-1.20.90.70.70.90.90.90.3-0.8
Bone: trabecular thickness0.10.20.70.8-0.30.4-0.80.30.20.1-0.10.30.2-0.0-0.1-0.1-0.7-0.1
Bone: trabecular tissue density0.20.20.6-0.30.7-0.80.4-0.7-0.6-0.60.30.20.40.20.30.30.7-0.3
Water consumed over 24 hours3.33.99.50.0-1.61.53.11.41.71.8-2.0-2.3-1.3-2.1-2.0-2.02.92.1
Number of responses in last shaping day0.40.44.32.10.40.0-0.8-0.3-0.0-0.3-0.10.50.6-0.00.1-0.1-0.60.0