C3h15orf62

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	NM_001399846.1	0.18	0.08	5.9e-15	0.12	0.1	0.1	0.11	1.8e-13	9.9e-12	1.1e-10	2.9e-12
2	Liver	isoform ratio	NM_001399847.1	0.2	0.08	9.4e-16	0.13	0.11	0.1	0.12	4.5e-14	2.9e-12	8.8e-11	6.2e-13
3	Eye	isoform ratio	NM_001399846.1	0.57	0.15	1.6e-04	0.19	0.16	0.16	0.16	6.6e-04	2.1e-03	1.8e-03	2.3e-03
4	Eye	isoform ratio	NM_001399847.1	0.59	0.15	1.0e-04	0.2	0.16	0.18	0.17	4.9e-04	1.8e-03	1.1e-03	1.5e-03
5	Liver	gene expression	C3h15orf62	0.47	0.12	0.0e+00	0.33	0.34	0.35	0.35	4.1e-37	2.0e-39	9.6e-40	7.4e-40
6	NAcc	gene expression	C3h15orf62	0.05	0.03	3.6e-06	0.02	0.04	0.03	0.03	3.0e-04	1.8e-06	7.9e-06	1.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.6	1.1	1.5	1.2	-1.2	1.2	-1.2	0.6	-0.3
Area under the delay curve	3.4	3.9	6.1	2.2	-2.2	1.9	-1.9	-0.7	-2.5
BMI with tail	3.9	13.5	19.8	4.4	-4.4	4.2	-4.2	-0.1	-2.4
BMI without tail	5.1	15.5	23.4	4.8	-4.8	4.6	-4.6	0.9	-1.9
Body weight	4.4	19.1	27.0	5.2	-5.2	5.1	-5.1	-0.3	-2.9
Weight adjusted by age	1.2	1.8	2.4	1.4	-1.4	1.5	-1.5	-1.0	-1.3
Bone surface	0.3	0.6	0.7	0.8	-0.8	0.9	-0.9	0.8	0.3
Bone volume	0.5	0.8	1.1	1.0	-1.0	1.0	-1.0	0.8	0.1
Breakpoint value in progressive ratio session	0.4	0.5	0.8	-0.7	0.7	-0.6	0.6	0.7	0.9
Number of licking bursts	0.6	1.0	2.0	-0.9	0.9	-0.6	0.6	1.4	1.2
Context. condit. distance diff. score	1.1	1.3	2.0	1.2	-1.2	1.2	-1.2	1.4	0.5
Locomotion velocity, session 1	1.4	1.5	2.2	-1.5	1.5	-1.5	1.5	-0.7	-0.0
Locomotion distance, session 1	0.5	0.7	1.0	-1.0	1.0	-0.9	0.9	-0.5	-0.0
Locomotion velocity, session 2	1.4	1.6	2.1	1.3	-1.3	1.4	-1.4	0.0	-1.4
Locomotion distance, session 2	0.3	0.4	0.7	-0.8	0.8	-0.5	0.5	0.4	0.5
Locomotion velocity, session 3	0.2	0.2	0.3	0.4	-0.4	0.4	-0.4	0.3	-0.6
Locomotion distance, session 3	0.7	0.7	3.0	-0.2	0.2	-0.1	0.1	1.7	1.1
Stereotopy head waving bouts, day 3	3.9	4.6	6.2	2.2	-2.2	2.5	-2.5	-1.0	-2.1
Stereotopy head waving duration, day 3	4.8	5.7	7.5	2.5	-2.5	2.7	-2.7	-0.9	-2.5
Locomotion velocity, session 7	0.3	0.4	0.9	0.6	-0.6	0.5	-0.5	0.9	0.2
Locomotion distance, session 7	0.4	0.6	1.5	-0.3	0.3	-0.4	0.4	1.1	1.2
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	-0.1	0.1	-0.1	0.1	-0.7	-0.4
Stereotopy head waving duration, day 7	0.2	0.2	0.9	0.0	-0.0	-0.1	0.1	-1.0	-0.6
Locomotion velocity, session 8	2.7	3.3	4.6	2.1	-2.1	2.1	-2.1	0.4	-1.4
Locomotion distance, session 8	0.5	0.7	1.9	0.6	-0.6	0.7	-0.7	1.4	0.6
Degree of sensitization distance	0.5	0.5	0.6	-0.7	0.7	-0.8	0.8	-0.8	0.4
Degree of sensitization stereotypy	0.5	0.5	0.8	-0.7	0.7	-0.9	0.9	-0.4	0.5
Conditioned locomotion	1.3	1.5	2.2	1.5	-1.5	1.4	-1.4	0.7	-0.3
Cocaine response after cond. corrected	1.0	1.1	2.5	-0.8	0.8	-1.0	1.0	1.6	1.0
Cocaine response after cond. not corrected	0.9	1.1	1.9	-0.9	0.9	-1.1	1.1	1.4	0.9
Cocaine response before conditioning	0.2	0.2	1.0	-0.1	0.1	0.1	-0.1	-1.0	-0.7
Saline control response	1.8	2.4	2.8	1.4	-1.4	1.7	-1.7	-1.6	-1.5
Bone: connectivity density	0.3	0.5	0.7	0.7	-0.7	0.6	-0.6	-0.8	-0.7
Bone: cortical apparent density	2.1	2.9	3.8	-1.8	1.8	-1.8	1.8	0.6	1.9
Bone: cortical area	1.4	2.2	3.1	1.7	-1.7	1.8	-1.8	0.0	-1.0
Bone: cortical porosity	0.1	0.2	0.7	0.1	-0.1	0.2	-0.2	0.8	-0.4
Bone: cortical porosity	0.5	0.6	0.7	0.7	-0.7	0.8	-0.8	0.5	-0.8
Bone: cortical thickness	1.3	2.2	3.2	1.6	-1.6	1.8	-1.8	-0.0	-1.2
Bone: cortical thickness	0.4	0.5	2.1	-0.3	0.3	-0.2	0.2	1.4	0.8
Bone: cortical tissue density	2.0	2.8	3.4	-1.8	1.8	-1.8	1.8	0.6	1.8
Condit. Reinf. active minus inactive responses	1.0	1.1	2.3	-0.8	0.8	-1.2	1.2	-1.5	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.8	0.5	-0.5	0.3	-0.3	-0.9	-0.4
Condit. Reinf. active responses	2.5	3.0	4.4	-1.7	1.7	-2.1	2.1	-1.7	0.8
Condit. Reinf. inactive responses	2.8	3.4	4.8	-2.0	2.0	-2.2	2.2	-0.6	1.5
Incentive salience index mean	2.1	2.5	3.6	-1.6	1.6	-1.8	1.8	-1.9	0.4
Condit. Reinf. lever presses	1.7	2.3	3.6	-1.7	1.7	-1.5	1.5	-1.9	0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.2	-0.2	0.1	-0.1	-0.6	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.1	-0.1	0.1	-0.1	-0.2	0.4
Condit. Reinf. active responses	0.2	0.3	0.9	0.4	-0.4	0.4	-0.4	-0.9	-0.0
Condit. Reinf. inactive responses	0.5	0.6	2.3	0.5	-0.5	0.5	-0.5	-1.5	-0.7
Condit. Reinf. lever presses	0.9	1.2	4.0	0.7	-0.7	0.7	-0.7	-2.0	-1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	1.9	0.3	-0.3	0.2	-0.2	-1.4	-0.2
Conditioned reinforcement - actives	0.0	0.1	0.2	-0.1	0.1	-0.3	0.3	-0.4	-0.3
Conditioned reinforcement - inactives	0.2	0.2	1.0	0.2	-0.2	0.0	-0.0	1.0	0.5
Conditioned locomotion	0.9	1.1	3.2	0.5	-0.5	0.3	-0.3	-1.8	-1.7
Patch foraging indifference point 0 sec	3.7	6.8	10.7	2.3	-2.3	2.2	-2.2	-3.2	-3.3
Patch foraging indifference point AUC	1.3	1.9	2.7	-1.6	1.6	-1.6	1.6	-0.3	0.9
Delay disc. indifference point, 0s delay	1.3	1.4	3.4	0.7	-0.7	0.6	-0.6	-1.8	-1.8
Delay disc. indifference point, 16s delay	0.8	0.9	2.2	1.0	-1.0	0.8	-0.8	-0.2	-1.5
Delay disc. indifference point, 2s delay	0.7	0.7	1.3	1.2	-1.2	0.8	-0.8	-0.4	-0.6
Delay disc. indifference point, 24s delay	0.4	0.5	0.8	-0.7	0.7	-0.6	0.6	-0.9	-0.6
Delay disc. indifference point, 4s delay	1.7	1.7	2.7	1.4	-1.4	1.4	-1.4	-0.5	-1.6
Delay disc. indifference point, 8s delay	5.8	6.8	8.8	2.9	-2.9	2.7	-2.7	-0.8	-3.0
Indifference point function ln k	2.3	4.0	5.7	2.3	-2.3	2.4	-2.4	1.2	-0.8
Indifference point function log k	2.3	4.0	5.7	2.3	-2.3	2.4	-2.4	1.2	-0.8
Patch foraging total patch changes 0 sec	3.0	5.6	8.7	2.1	-2.1	2.0	-2.0	-2.9	-2.9
Patch foraging total patch changes 12 sec	0.7	0.9	4.2	-0.0	0.0	0.2	-0.2	-2.1	-1.0
Patch foraging total patch changes 18 sec	0.3	0.5	1.4	-0.5	0.5	-0.7	0.7	-1.2	-0.2
Patch foraging total patch changes 24 sec	1.5	2.6	3.5	1.7	-1.7	1.5	-1.5	-1.4	-1.9
Patch foraging total patch changes 6 sec	0.4	0.6	2.8	0.2	-0.2	-0.1	0.1	-1.7	-0.9
Patch foraging time to switch 0 sec	0.5	1.1	3.5	-0.8	0.8	-0.9	0.9	-1.9	-0.3
Patch foraging water rate 0 sec	0.3	0.7	1.6	0.8	-0.8	0.8	-0.8	1.3	0.5
Patch foraging water rate 12 sec	0.8	1.6	6.7	-0.2	0.2	-0.2	0.2	2.6	1.7
Patch foraging water rate 18 sec	0.5	0.8	2.4	0.9	-0.9	0.7	-0.7	1.5	0.1
Patch foraging water rate 24 sec	0.7	0.9	3.5	0.1	-0.1	0.0	-0.0	1.9	1.4
Patch foraging water rate 6 sec	2.3	3.3	6.1	-1.4	1.4	-1.4	1.4	2.4	2.5
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.4	-0.0	0.0	0.2	-0.2	1.0	1.2
Distance traveled before self-admin	0.5	0.7	1.0	1.0	-1.0	0.9	-0.9	-0.0	-0.5
Distance traveled after self-admin	0.1	0.1	0.3	-0.0	0.0	-0.3	0.3	0.1	0.5
Extensor digitorum longus weight	0.3	1.2	2.0	1.1	-1.1	1.4	-1.4	0.6	-0.6
Bone: elastic displacement	0.2	0.2	0.6	0.3	-0.3	0.1	-0.1	-0.8	-0.7
Bone: elastic work	0.6	0.8	0.9	0.9	-0.9	0.9	-0.9	-0.9	-0.9
Bone: endosteal estimation	0.2	0.5	2.0	0.1	-0.1	-0.1	0.1	1.4	0.9
Bone: endosteal perimeter	0.1	0.1	0.4	0.1	-0.1	-0.1	0.1	0.6	0.5
Epididymis fat weight	0.6	2.1	2.8	1.7	-1.7	1.6	-1.6	0.1	-1.3
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	-0.2	0.2	-0.2	0.2	0.9	0.9
Delta time in open arm before/after self-admin	0.9	0.9	2.7	0.7	-0.7	0.6	-0.6	1.7	1.0
Diff in mean of infusions in LGA sessions	0.3	0.4	1.6	-0.5	0.5	-0.4	0.4	-1.3	-0.0
Delay discount exponential model param	2.8	3.1	4.7	-1.9	1.9	-1.7	1.7	0.6	2.2
Extinction: sum of active levers before priming	0.3	0.4	0.5	-0.7	0.7	-0.7	0.7	-0.4	-0.1
Active lever presses in extinction session 6	0.0	0.0	0.2	-0.0	0.0	-0.0	0.0	-0.3	-0.4
Bone: final force	0.3	0.5	0.6	0.8	-0.8	0.8	-0.8	0.6	0.2
Bone: final moment	0.3	0.4	0.6	0.8	-0.8	0.7	-0.7	0.6	0.2
Food consumed during 24 hour testing period	0.4	0.6	1.5	-0.6	0.6	-0.4	0.4	1.2	1.0
Glucose	0.9	1.5	1.8	1.3	-1.3	1.3	-1.3	1.4	0.1
Heart weight	2.9	4.5	7.4	2.3	-2.3	2.7	-2.7	0.5	-1.0
Delay discount hyperbolic model param	2.7	3.0	4.2	-1.9	1.9	-1.7	1.7	0.6	2.1
Intermittent access intake day 1-15 change	0.6	1.3	5.8	0.4	-0.4	0.1	-0.1	2.4	1.3
Intermittent access intake escalation	0.5	1.1	4.5	0.6	-0.6	0.3	-0.3	2.1	1.1
Intermittent access intake escalation 2	1.7	1.9	8.8	-0.1	0.1	-0.3	0.3	3.0	1.6
Intermitt. access day 1 inactive lever presses	0.4	1.5	1.9	1.4	-1.4	1.3	-1.3	-0.7	-1.1
Intermitt. access day 15 inactive lever presses	0.2	0.5	0.7	0.5	-0.5	0.8	-0.8	0.9	0.4
Intermitt. access escalation Index	0.1	0.1	0.6	0.3	-0.3	-0.0	0.0	-0.8	0.1
Intermittent access day 1 total infusions	0.2	0.4	1.3	0.2	-0.2	0.1	-0.1	-1.2	-0.9
Intermittent access day 15 total infusions	0.2	0.3	0.5	0.7	-0.7	0.5	-0.5	0.6	0.1
Intermittent access terminal intake (last 3 days)	0.4	0.5	2.2	0.5	-0.5	0.3	-0.3	1.5	0.7
Intermittent access total infusions	0.1	0.1	0.2	0.4	-0.4	0.4	-0.4	0.2	-0.1
Intermittent access day 1 locomotion	1.8	2.3	4.2	1.3	-1.3	1.4	-1.4	-1.5	-2.1
Intermittent access day 15 total locomotion	0.4	0.8	1.6	0.8	-0.8	0.8	-0.8	1.3	0.3
Intermittent access total locomotion	0.4	0.4	0.6	0.7	-0.7	0.7	-0.7	-0.1	-0.7
Intermittent access standard deviation	0.5	1.0	4.5	0.1	-0.1	0.1	-0.1	2.1	1.2
Left kidney weight	2.9	13.4	19.5	4.2	-4.2	4.4	-4.4	0.3	-2.4
Right kidney weight	4.6	20.8	28.1	5.3	-5.3	5.3	-5.3	-0.2	-3.5
Cocaine induced anxiety	1.6	2.2	2.9	1.4	-1.4	1.6	-1.6	-1.2	-1.7
Post-drug Anxiety	1.4	1.5	2.1	1.3	-1.3	1.5	-1.5	-0.4	-0.9
Baseline Anxiety	0.2	0.3	0.7	-0.3	0.3	-0.3	0.3	0.7	0.9
Tail length	1.4	5.5	7.9	2.7	-2.7	2.8	-2.8	1.4	-0.4
Length with tail	1.0	4.3	6.5	2.4	-2.4	2.6	-2.6	0.1	-1.1
Length without tail	0.4	1.4	2.2	1.3	-1.3	1.5	-1.5	0.1	-0.8
Times rat made contact with spout	0.4	0.4	0.7	0.3	-0.3	0.8	-0.8	-0.7	-0.7
Lifetime Intake	0.1	0.1	0.1	0.2	-0.2	0.3	-0.3	-0.0	-0.3
Liver weight, left	2.0	3.3	4.7	2.2	-2.2	2.2	-2.2	-0.2	-1.0
Liver weight, right	2.4	4.2	5.6	2.3	-2.3	2.4	-2.4	-0.6	-1.7
Locomotor activity	0.1	0.1	0.2	-0.4	0.4	-0.1	0.1	-0.4	-0.3
Locomotor testing distance	0.1	0.2	0.3	-0.5	0.5	-0.4	0.4	-0.4	-0.2
Locomotor testing rearing	0.9	1.9	3.1	-1.7	1.7	-1.4	1.4	-0.1	1.1
Locomotion in novel chamber	0.3	0.4	0.6	0.6	-0.6	0.8	-0.8	-0.3	-0.5
Locomotion in novel chamber post-restriction	0.8	1.3	2.3	1.5	-1.5	1.0	-1.0	0.9	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.3	0.5	-0.6	0.6	-0.7	0.7	0.2	-0.0
Change in fecal boli incidents, locomotor task	1.6	1.6	2.5	1.4	-1.4	1.6	-1.6	0.7	-0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	0.8	-0.3	0.3	-0.6	0.6	0.8	0.9
Bouts of movement, locomotor time 1	3.0	3.4	5.5	-2.3	2.3	-2.1	2.1	-0.2	0.8
Total resting periods, locomotor time 1	3.4	3.8	6.2	-2.5	2.5	-2.2	2.2	-0.3	1.0
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.5	0.5	-0.3	0.3	-0.3	0.3
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.1	0.1	-0.3	0.3	-0.6	-0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.2	0.4
Time >=10cm from walls, locomotor time 2	5.1	7.6	10.6	3.3	-3.3	3.2	-3.2	-0.8	-1.9
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.1	0.4
Total resting periods, locomotor time 2	0.0	0.1	0.2	-0.2	0.2	-0.3	0.3	-0.1	0.5
Rest time, locomotor task time 2	3.2	4.1	6.1	-2.5	2.5	-2.3	2.3	0.2	1.4
Distance moved, locomotor task time 2	1.9	2.3	3.3	1.8	-1.8	1.5	-1.5	-1.0	-1.4
Vertical activity count, locomotor time 2	1.5	2.1	3.6	1.9	-1.9	1.6	-1.6	-0.4	-0.6
Light reinforcement 1	1.5	3.6	14.7	0.5	-0.5	1.1	-1.1	-3.8	-2.0
Light reinforcement 2	1.0	1.6	3.1	-1.8	1.8	-1.0	1.0	-1.0	0.5
Bone: marrow area	0.2	0.4	1.7	0.2	-0.2	0.1	-0.1	1.3	0.8
Bone: maximum diameter	0.5	0.9	1.3	1.2	-1.2	1.1	-1.1	0.1	-0.4
Bone: maximum force	1.1	2.0	2.9	1.7	-1.7	1.7	-1.7	-0.0	-0.7
Bone: maximum moment	1.0	1.7	2.6	1.6	-1.6	1.5	-1.5	0.0	-0.7
Mean time between licks in bursts	0.2	0.5	0.6	-0.7	0.7	-0.7	0.7	0.8	0.3
Mean num. licks in bursts	0.9	1.3	2.4	1.0	-1.0	1.0	-1.0	-1.5	-1.4
Cd content in liver	0.2	0.2	0.4	0.6	-0.6	0.4	-0.4	0.1	-0.2
Co content in liver	0.3	0.3	0.4	0.6	-0.6	0.6	-0.6	0.4	-0.6
Cu content in liver	1.0	1.1	2.1	-0.8	0.8	-0.9	0.9	1.5	1.3
Fe content in liver	3.7	4.5	6.0	-2.4	2.4	-2.5	2.5	-0.2	1.9
K content in liver	0.2	0.2	0.9	0.3	-0.3	0.3	-0.3	1.0	0.4
Mg content in liver	0.9	0.9	3.6	0.6	-0.6	0.6	-0.6	1.9	0.8
Mn content in liver	1.9	2.1	2.8	1.7	-1.7	1.7	-1.7	-0.2	-1.1
Na content in liver	1.0	1.1	1.3	-1.1	1.1	-1.1	1.1	0.7	1.2
Rb content in liver	3.8	4.4	6.4	2.5	-2.5	2.4	-2.4	0.8	-1.1
Se content in liver	0.1	0.1	0.2	0.2	-0.2	0.1	-0.1	0.5	0.4
Sr content in liver	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.2	-0.3
Zn content in liver	2.3	2.6	4.3	-1.4	1.4	-1.6	1.6	1.5	2.1
Bone: minimum diameter	2.1	3.8	5.2	2.3	-2.3	2.1	-2.1	-0.3	-1.9
Time in familiar zone, hab. session 1	1.7	1.6	2.3	-1.5	1.5	-1.3	1.3	0.5	1.0
Time in novel zone, hab. session 1	1.9	1.9	3.0	1.7	-1.7	1.5	-1.5	-0.5	-1.0
Total zone transitions, hab. session 1	0.2	0.3	0.4	-0.7	0.7	-0.5	0.5	-0.5	-0.2
Total locomotion distance, hab. session 1	0.2	0.2	0.5	-0.6	0.6	-0.3	0.3	-0.7	-0.3
Locomotion velocity, hab. session 1	0.4	0.5	1.0	-0.8	0.8	-0.5	0.5	-1.0	-0.5
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.2	0.2	-0.2	0.2	0.1	0.3
Time in novel zone, hab. session 2	0.8	0.8	1.2	1.1	-1.1	0.9	-0.9	-0.2	-0.9
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.4	0.4	-0.2	0.2	0.3	0.1
Total locomotion distance, hab. session 2	0.0	0.0	0.2	-0.2	0.2	0.0	-0.0	-0.4	-0.2
Locomotion velocity, hab. session 2	0.1	0.1	0.4	-0.4	0.4	-0.1	0.1	-0.6	-0.2
Novel to familiar place preference ratio	1.3	1.4	1.6	1.3	-1.3	1.3	-1.3	-1.0	-1.1
Novelty place preference	1.3	1.4	1.6	1.3	-1.3	1.3	-1.3	-1.0	-1.1
Time in novel zone, NPP test	1.2	1.2	1.5	1.2	-1.2	1.2	-1.2	-0.9	-1.0
Total zone transitions, NPP test	0.6	0.9	1.4	-1.1	1.1	-0.7	0.7	1.2	0.8
Total locomotion distance, NPP test	0.1	0.1	0.5	-0.1	0.1	0.2	-0.2	0.7	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.1	0.1	0.2	-0.2	0.6	-0.2
Intraocular pressure	0.6	0.8	1.3	-0.9	0.9	-1.1	1.1	-0.9	-0.3
Delta distance traveled before/after self-admin	0.4	0.4	0.7	-0.6	0.6	-0.9	0.9	-0.3	0.3
Delta ambulatory time before/after self-admin	0.6	0.8	1.1	-0.9	0.9	-1.0	1.0	-0.9	0.2
Parametrial fat weight	0.3	0.7	2.6	0.2	-0.2	0.5	-0.5	-1.6	-1.0
Pavlov. Cond. lever latency	0.2	0.3	1.0	0.4	-0.4	0.2	-0.2	1.0	0.4
Pavlov. Cond. magazine entry latency	0.7	0.9	4.6	0.1	-0.1	0.2	-0.2	-2.1	-0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.3	0.3	-0.2	0.2	0.1	0.5
Pavlov. Cond. index score	0.5	0.6	2.6	-0.5	0.5	-0.3	0.3	-1.6	-0.5
Pavlov. Cond. latency score	0.6	0.8	3.6	-0.3	0.3	-0.1	0.1	-1.9	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	1.4	-0.6	0.6	-0.3	0.3	-1.2	-0.4
Pavlov. Cond. magazine entry number	0.6	0.7	2.8	-0.3	0.3	-0.5	0.5	1.7	0.8
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.6	-0.9	0.9	-1.0	1.0	1.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.6	-0.6	0.6	-0.4	0.4	-1.3	-0.3
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.7	0.7	-0.5	0.5	-0.9	0.2
Pavlov. Cond. lever latency	1.6	2.2	2.8	-1.4	1.4	-1.6	1.6	1.7	1.3
Pavlov. Cond. magazine entry latency	0.3	0.4	2.2	0.1	-0.1	0.3	-0.3	-1.5	-0.2
Pavlov. Cond. change in total contacts	0.1	0.2	1.0	0.1	-0.1	0.2	-0.2	-1.0	0.1
Pavlov. Cond. index score	0.3	0.5	1.6	0.4	-0.4	0.6	-0.6	-1.3	-0.2
Pavlov. Cond. latency score	0.2	0.3	1.0	0.3	-0.3	0.6	-0.6	-1.0	-0.1
Pavlov. Cond. lever contacts	1.7	2.3	3.5	1.4	-1.4	1.5	-1.5	-1.9	-1.3
Pavlov. Cond. magazine entry number	0.1	0.2	0.8	-0.1	0.1	-0.3	0.3	0.9	-0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.0	0.8	-0.8	1.0	-1.0	0.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.6	0.4	-0.4	0.6	-0.6	-1.3	-0.2
Pavlov. Cond. response bias	1.2	1.7	3.4	1.1	-1.1	1.3	-1.3	-1.9	-0.9
Time in closed arm before self-admin	2.0	2.6	4.0	-2.0	2.0	-1.8	1.8	-0.6	0.8
Time in closed arm after self-admin	1.9	2.0	2.7	-1.7	1.7	-1.6	1.6	-0.3	1.1
Time in open arm before self-admin	0.8	0.9	1.2	0.9	-0.9	1.1	-1.1	-0.5	-1.1
Time in open arm after self-admin	2.0	2.2	3.0	1.6	-1.6	1.5	-1.5	1.7	0.3
Bone: periosteal estimation	0.5	1.0	1.4	1.2	-1.2	1.1	-1.1	0.6	-0.3
Bone: periosteal perimeter	1.0	1.8	2.5	1.6	-1.6	1.5	-1.5	-0.1	-1.0
Bone: post-yield work	0.2	0.3	1.3	-0.1	0.1	-0.1	0.1	1.2	0.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.2	0.2	-0.2	0.2	-0.5	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.2	0.2	-0.2	0.2	-0.5	-0.1
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.3	0.3	-0.2	0.2	-0.1	0.2
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	0.1	-0.0	0.0	-0.2	0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	0.0	-0.0	0.1	-0.1	-0.2	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.3	0.3	-0.3	0.6	-0.6	0.2	-0.0
Incentive Sensitization - Responses	0.0	0.0	0.1	0.2	-0.2	0.3	-0.3	0.1	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.2	-0.2	0.3	-0.3	0.0	0.0
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.9	-0.6	0.6	-0.6	0.6	1.4	1.2
Progressive ratio	0.1	0.2	0.3	-0.5	0.5	-0.4	0.4	-0.3	0.5
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.2	-0.2	-0.1	0.1	-0.1	-0.2
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.3	-0.3	0.1	-0.1	-0.0	-0.3
Retroperitoneal fat weight	2.6	11.0	13.5	3.5	-3.5	3.7	-3.7	-2.5	-2.9
Reaction time number correct	1.2	2.3	4.8	1.4	-1.4	1.5	-1.5	2.2	0.5
Reaction time mean minus median	0.3	0.8	1.3	1.0	-1.0	1.1	-1.1	-0.3	-0.7
Reaction time mean minus median AUC	1.1	2.9	4.3	1.9	-1.9	2.1	-2.1	-0.2	-1.2
Reaction time num false alarms	0.0	0.0	0.0	0.2	-0.2	0.1	-0.1	-0.1	-0.2
Reaction time num false alarms AUC	0.0	0.1	0.1	-0.2	0.2	-0.3	0.3	-0.0	0.2
Reaction time trials correct on left	1.2	2.3	4.8	1.4	-1.4	1.5	-1.5	2.2	0.5
Reaction time trials on left	1.2	2.2	4.5	1.4	-1.4	1.5	-1.5	2.1	0.5
Reaction time mean	0.8	1.2	1.7	-1.3	1.3	-1.2	1.2	-0.1	1.1
Reaction time mean AUC	0.3	0.5	0.8	-0.9	0.9	-0.7	0.7	-0.0	0.7
Median of all reaction times	2.3	3.2	4.4	-2.1	2.1	-2.0	2.0	-0.0	1.6
Reaction time omissions	0.8	1.1	1.8	0.9	-0.9	1.0	-1.0	-1.3	-1.2
Reaction time false alarm rate	0.4	0.6	1.4	-0.7	0.7	-0.8	0.8	-1.2	-0.2
Reaction time premature initiation rate	1.6	2.2	4.3	-1.5	1.5	-1.5	1.5	-2.1	0.1
Reaction time premature initiations	0.3	0.5	0.5	-0.7	0.7	-0.7	0.7	-0.7	0.5
Std. dev. reaction times	0.4	0.7	1.0	0.8	-0.8	1.0	-1.0	-0.6	-0.8
Reaction time trials completed	1.2	2.2	4.5	1.4	-1.4	1.5	-1.5	2.1	0.5
Reaction time trials AUC	1.0	1.9	4.8	1.2	-1.2	1.3	-1.3	2.2	0.8
Run reversals in cocaine runway, females	0.7	0.7	3.0	-0.1	0.1	0.1	-0.1	1.7	0.9
Run reversals in cocaine runway, males	0.6	0.6	1.2	-0.5	0.5	-1.1	1.1	0.3	0.6
Latency to leave start box in cocaine runway	0.1	0.2	0.3	-0.3	0.3	-0.5	0.5	-0.2	0.4
Latency to leave start box in cocaine runway, F	0.1	0.2	0.4	-0.4	0.4	-0.6	0.6	-0.1	0.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.6	0.1	-0.1	-0.1	0.1	-0.2	0.8
Std. dev. time between licks in bursts	1.6	2.2	2.8	1.6	-1.6	1.7	-1.7	-0.4	-1.6
Total sessions with >9 infusions	0.5	0.7	2.1	0.1	-0.1	-0.1	0.1	-1.4	-1.3
Short access day 1 total inactive lever presses	1.3	1.7	2.6	1.6	-1.6	1.3	-1.3	0.2	-1.3
Short access day 10 total inactive lever presses	0.4	0.9	1.6	0.7	-0.7	1.1	-1.1	1.3	0.6
Short access day 1 total infusions	0.1	0.1	0.6	0.1	-0.1	-0.2	0.2	-0.5	-0.8
Short access day 10 total infusions	0.3	0.4	1.7	-0.2	0.2	-0.3	0.3	-1.3	-0.7
Short access total infusions	0.1	0.2	0.6	-0.1	0.1	-0.1	0.1	-0.7	-0.7
Short access day 1 locomotion	0.5	0.6	1.3	-0.7	0.7	-0.7	0.7	-1.2	-0.6
Short access day 10 total locomotion	1.2	2.2	2.9	1.5	-1.5	1.7	-1.7	0.2	-1.7
Short access total locomotion	1.6	1.9	4.7	1.0	-1.0	1.0	-1.0	-1.6	-2.2
One hour access (0.3 mA shock)	1.6	1.9	5.8	-0.6	0.6	-0.4	0.4	2.4	2.1
Compulsive drug intake	1.1	1.3	4.1	-0.6	0.6	-0.2	0.2	2.0	1.8
One hour access (shock baseline)	0.1	0.1	0.5	0.0	-0.0	-0.1	0.1	-0.7	-0.2
Social response proportion	0.6	0.7	1.3	-0.7	0.7	-0.8	0.8	-0.9	1.1
Social responses	2.0	2.5	3.2	-1.8	1.8	-1.6	1.6	-1.2	1.4
Social time	0.1	0.2	0.4	-0.5	0.5	-0.3	0.3	-0.1	0.6
Soleus weight	0.2	0.5	0.8	-0.9	0.9	-0.7	0.7	0.2	0.9
Bone: stiffness	0.6	0.9	1.3	1.1	-1.1	1.1	-1.1	-0.0	-0.4
Tibialis anterior weight	0.1	0.3	1.2	-0.5	0.5	-0.3	0.3	0.4	1.1
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.3	0.5	-0.5	0.7	-0.7	-0.5	-1.1
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	0.5	-0.5	0.4	-0.4	0.9	0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.6	-0.0	0.0	-0.0	0.0	-0.8	-0.5
Time to tail flick, test, after self-admin	0.6	0.6	0.9	0.9	-0.9	0.8	-0.8	-0.6	-0.8
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	2.1	0.9	-0.9	0.7	-0.7	1.4	0.7
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.4	-0.4	0.3	-0.3	-0.4	-0.4
Tibia length	1.5	4.1	5.8	1.8	-1.8	1.9	-1.9	-2.1	-2.4
Ambulatory time before self-admin	0.7	1.0	1.4	1.2	-1.2	1.1	-1.1	-0.5	-0.9
Ambulatory time after self-admin	0.2	0.3	0.4	-0.5	0.5	-0.6	0.6	-0.1	0.6
Bone: tissue strength	0.5	0.5	0.7	0.8	-0.8	0.8	-0.8	0.1	-0.6
Total heroin consumption	0.1	0.1	0.2	-0.4	0.4	-0.1	0.1	0.4	-0.1
Bone: trabecular number	0.9	1.5	2.1	1.3	-1.3	1.3	-1.3	1.4	0.3
Bone: trabecular spacing	1.1	1.4	5.4	-0.6	0.6	-0.7	0.7	-2.3	-1.2
Bone: trabecular thickness	1.0	1.3	2.4	-1.0	1.0	-0.9	0.9	1.3	1.5
Bone: trabecular tissue density	3.5	5.2	7.1	-2.1	2.1	-2.1	2.1	2.7	2.6
Water consumed over 24 hours	0.6	0.8	1.5	-1.2	1.2	-0.8	0.8	-0.0	0.9
Number of responses in last shaping day	0.5	0.5	1.7	-0.4	0.4	-0.4	0.4	-1.3	-0.8