Hub : Genes

C3h11orf91

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression C3h11orf91 0.06 0.04 3.2e-07 0.05 0.03 0.04 0.04 7.6e-06 3.2e-04 5.7e-05 8.5e-05
2 Eye intron excision ratio chr3_110937756_110941256 0.87 0.31 4.1e-03 0.25 0.24 0.18 0.19 9.4e-05 1.4e-04 1.0e-03 6.8e-04
3 Adipose isoform ratio XM_017591901.3 0.12 0.09 1.3e-10 0.06 0.07 0.09 0.09 3.1e-07 2.5e-08 7.2e-10 2.8e-10
4 Brain isoform ratio XM_039105445.2 0.03 0.03 3.6e-04 0.03 0.03 0.03 -0 2.2e-03 1.6e-03 1.3e-03 5.5e-01
5 Adipose intron excision ratio chr3_110937756_110941256 0.06 0.05 1.2e-07 0.04 0.05 0.06 0.06 1.1e-05 2.3e-06 4.4e-07 7.5e-07
6 pVTA intron excision ratio chr3_110937314_110937644 0.03 0.03 1.3e-03 0.03 0.04 0.03 0.03 4.1e-03 4.1e-04 2.3e-03 1.9e-03
7 Adipose isoform ratio XM_039105443.2 0.06 0.05 1.8e-07 0.06 0.06 0.06 0.06 8.3e-07 4.8e-07 1.0e-06 1.0e-06
8 Adipose isoform ratio XM_039105441.2 0.27 0.13 0.0e+00 0.27 0.28 0.29 0.29 5.3e-30 3.9e-31 6.4e-33 6.9e-33
9 pVTA isoform ratio XM_039105445.2 0.06 0.05 2.3e-05 0.05 0.06 0.05 0.06 5.6e-05 2.1e-05 9.9e-05 3.1e-05
10 Adipose isoform ratio XM_039105445.2 0.07 0.06 1.7e-07 0.05 0.06 0.05 0.05 1.7e-06 6.0e-07 2.2e-06 2.2e-06
11 Adipose gene expression C3h11orf91 0.5 0.15 0.0e+00 0.54 0.53 0.54 0.54 2.2e-70 7.6e-70 1.5e-71 2.6e-70
12 BLA isoform ratio XM_039105445.2 0.05 0.05 6.8e-03 0.05 0 0.04 0.04 1.6e-03 2.1e-01 3.5e-03 2.9e-03
13 pVTA intron excision ratio chr3_110940087_110941256 0.23 0.15 6.5e-06 0.06 0.06 0.05 0.06 2.3e-05 7.0e-06 8.8e-05 1.2e-05
14 Eye intron excision ratio chr3_110940087_110941256 0.96 0 1.8e-03 0.24 0.24 0.21 0.1 1.5e-04 1.4e-04 3.3e-04 1.2e-02
15 pVTA intron excision ratio chr3_110937756_110941256 0.31 0.14 7.5e-05 0.04 0.04 0.04 0.04 2.8e-04 1.9e-04 4.5e-04 2.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.40.61.4-1.0-1.2-1.1-0.8-1.0-0.8-0.70.5-0.7-0.7-0.8-0.20.31.00.3
Area under the delay curve0.20.20.80.60.10.00.5-0.10.40.5-0.60.60.40.30.8-0.6-0.00.9
BMI with tail0.10.51.2-0.10.70.50.50.40.50.6-0.50.40.70.80.7-0.8-1.11.1
BMI without tail0.20.61.2-0.7-0.1-0.7-0.9-0.9-0.7-0.81.0-1.0-0.8-0.5-0.81.0-0.2-1.1
Body weight0.52.05.4-2.3-0.7-1.2-1.8-1.4-1.4-1.51.6-1.7-1.4-1.0-1.51.30.1-1.0
Weight adjusted by age2.13.15.71.01.71.81.71.71.71.7-1.61.51.82.01.7-1.9-2.42.0
Bone surface0.30.61.3-0.9-1.1-1.0-0.8-0.9-0.7-0.60.4-0.5-0.6-0.8-0.10.31.10.3
Bone volume0.81.43.0-1.2-1.7-1.4-1.2-1.3-1.2-1.10.8-0.9-1.1-1.3-0.60.71.70.0
Breakpoint value in progressive ratio session0.81.02.30.61.51.30.71.11.00.9-0.80.70.91.20.9-0.7-1.50.1
Number of licking bursts0.10.20.6-0.2-0.7-0.7-0.3-0.7-0.3-0.30.2-0.1-0.3-0.5-0.00.20.80.1
Context. condit. distance diff. score4.04.86.5-2.3-2.1-2.0-2.3-1.9-2.3-2.32.4-2.4-2.3-2.2-2.62.21.6-1.9
Locomotion velocity, session 10.30.32.31.50.20.40.70.40.40.4-0.20.60.20.00.40.20.3-0.7
Locomotion distance, session 10.20.20.80.7-0.00.20.60.20.40.4-0.60.50.40.20.5-0.70.20.9
Locomotion velocity, session 20.00.00.10.3-0.0-0.00.10.00.10.1-0.20.10.1-0.00.3-0.30.10.4
Locomotion distance, session 20.10.20.50.1-0.5-0.5-0.3-0.4-0.4-0.40.4-0.4-0.4-0.5-0.40.30.7-0.3
Locomotion velocity, session 30.40.53.3-0.1-0.20.00.40.10.40.5-0.70.70.50.30.9-1.00.21.8
Locomotion distance, session 30.10.10.40.2-0.4-0.20.2-0.2-0.10.0-0.20.10.0-0.20.3-0.20.40.6
Stereotopy head waving bouts, day 30.40.51.40.20.30.50.60.40.70.8-0.81.00.70.70.9-0.8-0.21.2
Stereotopy head waving duration, day 30.20.20.7-0.8-0.6-0.5-0.6-0.5-0.4-0.40.4-0.2-0.4-0.3-0.50.40.5-0.0
Locomotion velocity, session 70.20.20.7-0.5-0.10.0-0.4-0.0-0.4-0.50.5-0.7-0.3-0.2-0.80.3-0.2-0.5
Locomotion distance, session 70.20.20.90.40.60.80.40.80.30.2-0.1-0.10.30.5-0.1-0.3-1.0-0.2
Stereotopy head waving bouts, day 70.20.21.0-0.1-0.1-0.10.2-0.10.40.5-0.60.70.40.30.7-0.50.31.0
Stereotopy head waving duration, day 70.10.10.4-0.1-0.1-0.3-0.0-0.30.20.3-0.40.50.20.20.5-0.30.30.6
Locomotion velocity, session 80.60.81.9-0.3-0.7-0.6-0.7-0.6-0.8-0.91.0-0.9-0.9-0.9-1.01.10.6-1.4
Locomotion distance, session 83.04.35.2-1.8-2.2-2.0-2.1-1.9-2.2-2.22.2-2.2-2.1-2.2-2.32.01.8-1.6
Degree of sensitization distance0.40.42.70.10.40.5-0.20.4-0.2-0.40.7-0.7-0.30.0-0.90.7-0.6-1.6
Degree of sensitization stereotypy0.30.30.90.20.0-0.20.2-0.10.50.6-0.70.80.50.30.9-0.60.30.9
Conditioned locomotion4.95.68.62.62.02.12.52.02.62.7-2.72.92.52.22.7-2.3-1.42.0
Cocaine response after cond. corrected2.73.23.81.71.91.81.81.71.91.9-1.91.81.91.91.8-1.8-1.51.4
Cocaine response after cond. not corrected0.50.60.90.60.90.70.60.60.90.9-0.90.80.90.90.8-0.8-0.60.6
Cocaine response before conditioning6.07.28.4-2.7-2.8-2.9-2.8-2.9-2.8-2.72.7-2.7-2.7-2.8-2.72.62.4-1.9
Saline control response0.40.61.8-0.2-1.1-1.0-0.6-1.0-0.7-0.60.5-0.3-0.7-0.9-0.30.71.4-0.4
Bone: connectivity density0.40.61.2-0.9-1.0-1.1-0.8-1.0-0.8-0.70.5-0.7-0.6-0.8-0.20.30.80.3
Bone: cortical apparent density0.20.31.0-0.50.30.1-0.50.0-0.3-0.40.6-0.7-0.4-0.1-1.00.5-0.5-1.0
Bone: cortical area0.71.12.2-1.2-0.4-0.5-1.3-0.6-1.1-1.11.2-1.3-1.1-0.8-1.11.30.1-1.5
Bone: cortical porosity0.20.20.40.50.30.30.50.40.40.4-0.60.40.50.30.4-0.6-0.10.6
Bone: cortical porosity0.10.10.20.40.30.30.30.40.30.3-0.40.20.30.30.1-0.4-0.30.3
Bone: cortical thickness0.20.31.1-0.50.1-0.1-0.6-0.2-0.4-0.50.6-0.6-0.5-0.2-0.50.7-0.3-1.0
Bone: cortical thickness2.73.14.61.22.01.91.61.81.81.8-1.71.61.82.01.7-1.8-2.11.5
Bone: cortical tissue density0.20.30.9-0.50.20.0-0.5-0.0-0.3-0.40.6-0.6-0.4-0.1-1.00.5-0.4-0.9
Condit. Reinf. active minus inactive responses1.41.62.7-1.7-1.5-1.4-1.3-1.3-1.4-1.31.3-1.3-1.2-1.3-1.11.01.2-0.4
Condit. Reinf. active-inactive response ratio3.53.88.3-2.9-1.9-1.9-2.1-1.8-2.1-2.12.0-2.2-1.9-1.8-1.91.61.3-0.7
Condit. Reinf. active responses0.40.50.9-0.6-1.0-0.9-0.6-0.7-0.8-0.70.7-0.6-0.7-0.9-0.50.60.9-0.2
Condit. Reinf. inactive responses0.50.62.31.50.80.60.90.60.90.8-0.70.90.70.70.9-0.5-0.4-0.0
Incentive salience index mean1.41.72.1-1.4-1.5-1.4-1.3-1.3-1.4-1.31.4-1.3-1.3-1.4-1.11.21.3-0.8
Condit. Reinf. lever presses0.91.21.7-0.7-1.1-1.2-1.0-1.1-1.1-1.11.2-1.0-1.2-1.2-0.91.31.1-1.2
Condit. Reinf. active minus inactive responses1.52.02.7-1.6-1.3-1.3-1.5-1.3-1.5-1.51.6-1.6-1.4-1.4-1.41.41.0-1.2
Condit. Reinf. active-inactive response ratio4.55.36.3-2.4-2.1-2.2-2.5-2.2-2.4-2.42.4-2.5-2.4-2.2-2.42.31.8-2.0
Condit. Reinf. active responses0.71.02.0-1.4-1.0-1.0-1.2-1.0-1.1-1.11.1-1.1-1.0-1.0-0.90.90.8-0.6
Condit. Reinf. inactive responses0.30.41.50.20.30.30.50.40.60.7-0.80.70.70.50.8-0.9-0.31.2
Condit. Reinf. lever presses1.01.42.3-1.5-1.1-1.1-1.3-1.1-1.3-1.31.3-1.3-1.2-1.2-1.21.10.8-0.8
Condit. Reinf. lever reinforcers received0.70.91.9-1.4-1.0-0.9-1.1-1.0-1.1-1.01.0-1.0-0.9-1.0-0.80.80.7-0.4
Conditioned reinforcement - actives3.25.57.4-2.2-2.0-2.5-2.6-2.7-2.4-2.52.6-2.4-2.5-2.2-2.12.61.6-2.1
Conditioned reinforcement - inactives4.66.89.2-2.4-3.0-3.0-2.6-2.9-2.8-2.72.5-2.6-2.7-2.7-2.52.22.5-1.1
Conditioned locomotion0.81.03.4-1.8-1.3-1.3-1.1-1.3-1.0-0.90.7-0.9-0.8-0.7-0.70.30.50.7
Patch foraging indifference point 0 sec1.12.08.90.50.50.61.20.81.21.4-1.71.61.41.11.4-2.0-0.53.0
Patch foraging indifference point AUC0.60.92.10.91.31.00.80.81.00.9-0.70.80.91.20.9-0.5-1.4-0.2
Delay disc. indifference point, 0s delay0.00.00.10.2-0.0-0.2-0.1-0.3-0.2-0.20.1-0.3-0.2-0.1-0.3-0.0-0.10.0
Delay disc. indifference point, 16s delay1.21.32.20.81.41.11.10.81.11.1-1.11.01.21.31.1-1.2-1.51.1
Delay disc. indifference point, 2s delay0.10.10.40.00.30.20.20.10.30.3-0.20.30.30.40.6-0.3-0.60.4
Delay disc. indifference point, 24s delay0.30.41.00.70.40.30.60.20.60.7-0.70.80.60.41.0-0.5-0.10.7
Delay disc. indifference point, 4s delay0.30.30.70.90.30.30.70.30.50.6-0.60.60.50.40.8-0.6-0.30.7
Delay disc. indifference point, 8s delay0.20.20.90.1-0.8-0.8-0.2-0.8-0.3-0.20.0-0.1-0.3-0.50.00.01.00.3
Indifference point function ln k0.61.01.6-1.0-1.3-1.0-1.0-0.8-1.1-1.10.8-1.0-1.0-1.2-1.30.61.2-0.1
Indifference point function log k0.61.01.6-1.0-1.3-1.0-1.0-0.8-1.1-1.10.8-1.0-1.0-1.2-1.30.61.2-0.1
Patch foraging total patch changes 0 sec1.01.99.20.40.30.51.10.71.11.3-1.71.51.41.01.4-2.0-0.33.0
Patch foraging total patch changes 12 sec0.00.00.2-0.2-0.2-0.20.1-0.30.10.1-0.10.10.10.10.5-0.1-0.00.2
Patch foraging total patch changes 18 sec0.81.23.3-0.00.80.60.60.41.11.2-1.31.31.21.21.2-1.4-1.11.8
Patch foraging total patch changes 24 sec1.42.45.90.31.21.01.20.81.51.7-1.71.71.71.61.7-1.9-1.52.4
Patch foraging total patch changes 6 sec0.91.34.00.60.70.50.90.41.11.2-1.51.21.31.11.1-1.6-0.92.0
Patch foraging time to switch 0 sec0.10.10.5-0.70.1-0.1-0.1-0.1-0.00.0-0.0-0.10.10.30.1-0.4-0.40.7
Patch foraging water rate 0 sec0.00.10.4-0.0-0.10.10.10.20.20.2-0.40.20.20.10.1-0.40.30.6
Patch foraging water rate 12 sec0.00.10.4-0.20.40.4-0.10.50.10.0-0.0-0.10.10.2-0.3-0.0-0.6-0.3
Patch foraging water rate 18 sec0.81.22.0-0.8-1.1-1.1-1.0-0.9-1.1-1.11.2-0.9-1.2-1.2-0.81.41.1-1.4
Patch foraging water rate 24 sec0.30.41.4-0.50.10.1-0.50.1-0.4-0.50.7-0.7-0.5-0.2-1.00.7-0.5-1.2
Patch foraging water rate 6 sec0.00.00.40.10.00.2-0.00.30.0-0.0-0.1-0.00.0-0.0-0.6-0.1-0.00.0
Seeking ratio, delayed vs. immediate footshock0.30.30.7-0.5-0.4-0.3-0.6-0.3-0.5-0.60.6-0.7-0.5-0.5-0.80.60.2-0.8
Distance traveled before self-admin0.00.10.5-0.70.00.10.00.3-0.0-0.10.2-0.1-0.00.2-0.1-0.0-0.40.2
Distance traveled after self-admin0.40.41.1-1.1-0.2-0.2-0.7-0.2-0.6-0.60.9-0.8-0.6-0.3-0.60.8-0.4-0.9
Extensor digitorum longus weight0.20.71.00.61.00.70.60.60.90.8-0.90.70.91.00.8-0.9-0.90.8
Bone: elastic displacement0.70.92.20.61.31.20.71.20.90.8-0.70.60.91.10.8-0.7-1.50.2
Bone: elastic work0.81.03.2-0.01.31.20.71.20.80.8-0.70.60.91.20.9-0.8-1.80.7
Bone: endosteal estimation0.20.30.60.30.40.70.50.60.50.6-0.70.60.60.50.7-0.7-0.40.8
Bone: endosteal perimeter0.30.61.1-0.4-0.9-0.8-0.7-0.9-0.8-0.70.7-0.6-0.8-0.9-0.40.81.1-0.6
Epididymis fat weight1.13.65.7-2.4-1.8-1.8-2.1-1.7-2.1-2.02.0-2.1-2.0-1.9-1.81.81.4-1.3
Delta time in closed arm before/after self-admin0.40.30.80.50.80.70.40.90.60.5-0.30.50.50.60.6-0.2-0.80.1
Delta time in open arm before/after self-admin0.30.31.90.2-0.8-0.60.4-0.40.00.2-0.30.50.0-0.40.5-0.11.40.5
Diff in mean of infusions in LGA sessions0.60.81.90.11.11.00.71.10.80.8-0.70.60.91.11.0-0.7-1.40.5
Delay discount exponential model param0.30.30.9-0.6-0.1-0.1-0.60.0-0.5-0.60.6-0.7-0.5-0.4-0.90.60.1-0.9
Extinction: sum of active levers before priming0.20.20.9-0.10.70.7-0.10.60.30.1-0.1-0.10.20.5-0.3-0.1-0.9-0.2
Active lever presses in extinction session 60.00.00.2-0.5-0.10.0-0.30.1-0.1-0.20.1-0.2-0.1-0.1-0.1-0.1-0.10.2
Bone: final force0.20.41.0-0.5-0.20.0-0.50.0-0.6-0.70.8-0.8-0.6-0.4-0.80.8-0.2-1.0
Bone: final moment0.10.20.6-0.40.10.3-0.40.3-0.4-0.40.5-0.6-0.4-0.2-0.70.5-0.5-0.8
Food consumed during 24 hour testing period6.69.110.6-2.2-2.9-2.9-3.1-2.9-3.0-3.13.2-3.0-3.2-3.1-3.03.33.0-3.1
Glucose3.04.76.5-2.1-1.8-1.9-2.3-1.9-2.2-2.32.3-2.3-2.3-2.1-2.52.31.7-2.3
Heart weight0.40.71.30.91.01.11.01.10.70.7-0.60.70.70.80.7-0.6-0.90.4
Delay discount hyperbolic model param0.30.41.0-0.7-0.2-0.2-0.7-0.1-0.5-0.60.7-0.8-0.6-0.4-1.00.70.1-0.9
Intermittent access intake day 1-15 change0.30.51.2-0.9-1.1-1.0-0.6-0.9-0.8-0.70.6-0.6-0.6-0.8-0.50.40.80.2
Intermittent access intake escalation0.40.91.6-1.1-1.3-1.2-0.9-1.2-1.0-0.90.8-0.9-0.8-0.9-0.70.51.00.2
Intermittent access intake escalation 21.72.02.9-0.9-1.7-1.6-1.2-1.6-1.5-1.41.4-1.3-1.4-1.5-1.31.31.7-0.9
Intermitt. access day 1 inactive lever presses0.31.14.3-1.8-0.1-0.2-1.2-0.2-1.0-1.21.0-1.7-0.8-0.4-2.10.4-0.7-0.3
Intermitt. access day 15 inactive lever presses0.51.02.4-1.5-0.9-0.8-1.2-0.7-1.1-1.11.0-1.2-1.0-0.9-1.30.80.6-0.6
Intermitt. access escalation Index0.30.41.50.8-0.3-0.50.1-0.7-0.1-0.10.10.2-0.3-0.60.50.81.1-1.2
Intermittent access day 1 total infusions2.23.56.1-2.1-2.1-2.3-2.2-2.5-1.9-1.81.5-1.7-1.8-1.8-1.61.41.9-0.6
Intermittent access day 15 total infusions2.74.17.4-2.1-2.6-2.6-2.1-2.7-2.0-1.91.7-1.7-1.9-2.1-1.41.52.4-0.5
Intermittent access terminal intake (last 3 days)3.14.07.2-1.7-2.5-2.6-2.0-2.7-2.0-1.91.8-1.6-2.0-2.1-1.31.82.4-1.0
Intermittent access total infusions3.84.58.5-1.7-2.7-2.8-2.2-2.9-2.1-2.01.8-1.8-2.1-2.2-1.51.72.6-0.9
Intermittent access day 1 locomotion1.11.32.8-1.3-1.7-1.6-1.3-1.6-1.2-1.10.7-1.0-1.0-1.0-0.90.31.20.7
Intermittent access day 15 total locomotion0.40.72.7-0.4-1.6-1.2-0.3-1.0-0.4-0.1-0.20.2-0.2-0.50.4-0.41.31.6
Intermittent access total locomotion0.91.13.2-1.1-1.8-1.5-0.9-1.3-1.0-0.80.4-0.7-0.7-0.8-0.5-0.11.21.4
Intermittent access standard deviation1.73.64.7-1.8-2.2-2.2-2.0-2.2-1.9-1.91.8-1.7-1.9-2.0-1.71.82.1-1.2
Left kidney weight1.04.76.8-2.5-1.6-1.5-2.5-1.5-2.2-2.32.6-2.4-2.3-1.9-2.42.61.0-2.6
Right kidney weight1.35.99.1-3.0-2.0-2.0-2.8-2.0-2.6-2.62.8-2.8-2.5-2.2-2.82.51.3-2.2
Cocaine induced anxiety0.10.10.80.20.40.60.00.7-0.0-0.10.2-0.20.00.3-0.10.1-0.9-0.2
Post-drug Anxiety1.01.12.90.51.41.40.71.30.90.8-0.80.61.01.20.7-0.9-1.70.6
Baseline Anxiety1.11.32.51.00.80.61.10.51.31.3-1.61.41.20.91.5-1.40.01.3
Tail length1.14.47.5-1.9-1.3-1.7-2.5-1.8-2.0-2.22.3-2.3-2.2-1.7-2.52.41.2-2.7
Length with tail1.56.312.1-3.5-1.7-2.1-3.1-2.2-2.5-2.72.7-2.9-2.6-2.0-3.02.41.2-2.2
Length without tail0.82.49.3-3.0-1.4-1.4-2.0-1.3-1.6-1.51.3-1.7-1.4-1.2-1.70.91.0-0.2
Times rat made contact with spout0.20.20.4-0.6-0.4-0.4-0.6-0.5-0.4-0.40.3-0.5-0.4-0.4-0.50.20.30.1
Lifetime Intake3.84.67.9-1.6-2.6-2.7-2.3-2.8-2.1-2.11.9-1.8-2.1-2.2-1.71.92.5-1.1
Liver weight, left1.83.05.0-2.2-1.3-1.2-1.9-1.3-1.8-1.92.0-2.1-1.8-1.5-2.11.70.6-1.6
Liver weight, right1.73.04.7-1.9-1.2-1.2-1.7-1.1-1.8-1.92.1-2.1-1.8-1.5-2.22.00.6-2.1
Locomotor activity0.00.00.3-0.0-0.3-0.10.10.0-0.10.0-0.10.1-0.0-0.10.1-0.10.60.3
Locomotor testing distance1.22.14.5-2.1-1.3-1.5-1.7-1.4-1.6-1.61.3-1.7-1.4-1.3-1.61.11.2-0.6
Locomotor testing rearing0.30.51.5-1.2-0.6-0.6-0.8-0.5-0.8-0.70.7-0.8-0.7-0.5-0.90.60.4-0.4
Locomotion in novel chamber0.50.72.3-0.5-1.3-1.0-0.6-1.0-0.8-0.70.5-0.4-0.7-1.0-0.30.41.50.2
Locomotion in novel chamber post-restriction0.40.71.31.10.90.81.00.80.90.9-0.90.90.90.80.7-0.9-0.70.7
Fecal boli incidents, locomotor time 13.45.09.32.02.92.62.02.42.32.1-2.01.92.22.51.9-1.8-3.00.8
Change in fecal boli incidents, locomotor task3.03.08.7-0.9-2.7-2.4-1.3-2.2-1.6-1.41.2-1.0-1.6-2.1-0.91.13.0-0.0
Time >=10cm from walls, locomotor time 10.10.11.20.60.5-0.00.1-0.30.10.00.2-0.0-0.10.1-0.10.4-0.2-1.1
Bouts of movement, locomotor time 10.10.21.0-0.30.80.4-0.10.10.20.1-0.2-0.10.20.5-0.2-0.2-1.00.0
Total resting periods, locomotor time 10.10.20.8-0.30.70.4-0.20.10.1-0.00.1-0.20.00.4-0.30.2-0.9-0.5
Rest time, locomotor task time 10.50.64.11.40.70.40.40.20.50.30.10.50.00.10.50.9-0.2-2.0
Distance moved, locomotor task time 11.01.52.1-1.3-1.4-1.3-1.1-1.2-1.3-1.31.2-1.3-1.2-1.3-1.30.81.3-0.2
Vertical activity count, locomotor time 10.10.11.0-0.4-0.4-0.2-0.1-0.1-0.2-0.1-0.2-0.30.0-0.2-0.2-0.60.31.0
Time >=10cm from walls, locomotor time 24.66.88.4-2.0-2.5-2.7-2.5-2.9-2.6-2.62.6-2.5-2.7-2.7-2.32.82.7-2.7
Bouts of movement, locomotor time 20.30.52.4-1.20.70.9-0.10.80.0-0.0-0.1-0.50.30.6-0.6-0.7-1.50.9
Total resting periods, locomotor time 20.30.41.9-1.20.50.7-0.20.7-0.1-0.1-0.0-0.50.20.5-0.6-0.6-1.40.8
Rest time, locomotor task time 21.62.03.81.91.41.41.51.31.61.6-1.41.71.41.31.5-1.1-1.10.6
Distance moved, locomotor task time 25.56.57.1-2.3-2.5-2.5-2.5-2.5-2.6-2.62.7-2.6-2.7-2.6-2.42.72.5-2.5
Vertical activity count, locomotor time 22.12.95.1-2.3-1.7-1.5-1.8-1.4-1.8-1.91.7-2.0-1.8-1.7-1.61.51.4-1.3
Light reinforcement 10.30.73.0-0.7-0.3-0.3-0.9-0.3-0.7-0.81.1-0.7-0.9-0.6-0.81.40.2-1.7
Light reinforcement 20.61.07.10.5-0.10.1-0.30.1-0.5-0.71.1-0.6-0.8-0.7-0.71.70.4-2.7
Bone: marrow area0.20.40.60.30.40.70.50.70.60.6-0.70.60.60.50.7-0.7-0.40.8
Bone: maximum diameter0.40.81.9-0.6-0.6-0.6-1.0-0.7-0.9-1.01.0-1.0-1.0-0.8-0.91.20.5-1.4
Bone: maximum force0.10.30.5-0.7-0.5-0.2-0.6-0.2-0.6-0.60.6-0.6-0.5-0.5-0.50.60.1-0.3
Bone: maximum moment0.00.10.3-0.5-0.10.2-0.30.2-0.2-0.20.3-0.3-0.2-0.1-0.20.2-0.4-0.0
Mean time between licks in bursts0.71.83.50.91.11.11.31.11.31.4-1.51.41.41.31.2-1.7-1.11.9
Mean num. licks in bursts0.00.10.2-0.40.20.2-0.30.1-0.1-0.20.2-0.4-0.10.1-0.50.1-0.3-0.3
Cd content in liver4.44.97.4-1.5-1.8-1.9-2.0-1.9-2.2-2.32.4-2.3-2.3-2.3-2.72.52.0-2.7
Co content in liver1.01.11.40.81.11.21.01.11.11.1-1.11.01.11.11.0-1.2-1.01.0
Cu content in liver0.60.71.40.81.01.20.91.20.90.8-0.70.70.80.90.7-0.7-0.80.1
Fe content in liver0.10.10.4-0.40.50.50.10.50.20.2-0.2-0.00.30.40.1-0.4-0.60.2
K content in liver4.13.96.11.22.02.21.82.21.91.9-1.91.62.02.21.5-2.3-2.52.2
Mg content in liver0.70.72.00.41.11.10.61.10.80.7-0.70.40.81.00.3-0.9-1.40.6
Mn content in liver0.80.92.01.21.21.21.01.20.90.8-0.60.70.81.00.7-0.5-1.4-0.0
Na content in liver0.60.62.1-1.5-0.3-0.3-1.0-0.4-0.8-0.90.8-1.2-0.7-0.3-1.10.5-0.4-0.4
Rb content in liver1.11.32.70.91.51.61.01.61.11.0-0.90.81.11.30.7-0.9-1.60.2
Se content in liver4.85.76.92.42.22.22.52.22.52.5-2.52.52.52.52.6-2.5-1.82.2
Sr content in liver0.10.10.40.00.30.30.20.30.30.3-0.40.20.40.40.0-0.6-0.40.7
Zn content in liver0.50.61.7-0.2-0.6-0.5-0.5-0.5-0.6-0.70.8-0.6-0.8-0.8-0.91.00.9-1.3
Bone: minimum diameter1.22.13.3-1.6-1.2-1.3-1.8-1.3-1.5-1.61.5-1.6-1.5-1.3-1.41.50.9-1.3
Time in familiar zone, hab. session 10.60.60.90.90.90.80.80.80.80.7-0.60.70.70.90.6-0.6-0.80.2
Time in novel zone, hab. session 11.21.21.7-1.3-1.2-1.2-1.1-1.1-1.2-1.11.1-1.1-1.1-1.2-0.91.01.1-0.6
Total zone transitions, hab. session 11.11.63.1-1.3-1.8-1.4-1.2-1.4-1.3-1.21.1-1.1-1.2-1.5-0.90.81.60.0
Total locomotion distance, hab. session 10.40.53.1-0.2-1.0-0.6-0.0-0.6-0.10.1-0.50.40.1-0.40.4-0.71.21.8
Locomotion velocity, hab. session 10.40.54.0-0.0-0.7-0.40.2-0.30.10.3-0.70.50.3-0.10.6-1.00.92.0
Time in familiar zone, hab. session 20.20.20.70.80.10.20.70.20.40.5-0.50.60.40.20.4-0.40.10.5
Time in novel zone, hab. session 20.60.61.9-0.7-0.3-0.4-0.9-0.4-0.7-0.80.9-0.9-0.8-0.6-0.81.10.2-1.4
Total zone transitions, hab. session 21.31.62.1-0.8-1.3-1.3-1.3-1.3-1.3-1.21.2-1.1-1.3-1.5-1.21.41.5-1.3
Total locomotion distance, hab. session 20.20.30.80.90.10.20.50.20.50.6-0.70.70.50.20.5-0.50.20.6
Locomotion velocity, hab. session 20.30.30.80.80.20.30.50.20.60.7-0.80.80.60.30.5-0.70.10.9
Novel to familiar place preference ratio0.70.82.4-1.6-0.9-0.8-0.9-0.9-1.0-0.90.7-1.0-0.8-0.8-0.90.30.50.4
Novelty place preference0.80.92.7-1.7-0.9-0.9-1.0-0.9-1.0-1.00.8-1.1-0.8-0.8-1.00.40.50.3
Time in novel zone, NPP test0.70.72.3-1.5-0.8-0.7-0.9-0.7-1.0-0.90.8-1.1-0.7-0.7-1.00.40.40.2
Total zone transitions, NPP test1.01.42.81.70.81.01.31.01.21.3-1.41.41.20.91.4-1.2-0.31.1
Total locomotion distance, NPP test1.62.14.02.00.81.11.61.11.51.6-1.81.81.51.01.7-1.6-0.21.6
Locomotion velocity, NPP test1.42.03.61.90.71.01.50.91.41.5-1.81.71.41.01.6-1.7-0.11.8
Intraocular pressure0.10.20.90.9-0.00.20.70.20.40.4-0.30.70.3-0.10.6-0.10.4-0.0
Delta distance traveled before/after self-admin0.20.21.4-0.10.30.0-0.5-0.2-0.2-0.30.6-0.4-0.3-0.0-0.10.7-0.7-1.2
Delta ambulatory time before/after self-admin0.40.51.8-0.5-0.1-0.3-0.8-0.4-0.6-0.60.9-0.8-0.6-0.4-0.61.0-0.3-1.3
Parametrial fat weight0.10.10.6-0.3-0.3-0.6-0.2-0.8-0.2-0.20.2-0.1-0.3-0.3-0.10.20.6-0.2
Pavlov. Cond. lever latency0.60.81.01.00.90.81.00.71.01.0-1.01.01.00.90.8-0.9-0.70.7
Pavlov. Cond. magazine entry latency1.41.72.8-1.6-0.8-0.9-1.4-0.9-1.3-1.41.6-1.5-1.4-1.2-1.41.60.4-1.7
Pavlov. Cond. change in total contacts0.10.10.5-0.20.50.60.20.50.20.2-0.10.20.20.40.1-0.1-0.70.2
Pavlov. Cond. index score0.50.60.9-0.9-0.5-0.5-0.8-0.4-0.8-0.80.9-0.9-0.9-0.7-0.81.00.4-1.0
Pavlov. Cond. latency score0.50.61.0-0.9-0.5-0.5-0.9-0.5-0.8-0.91.0-0.9-0.9-0.7-0.81.00.3-0.9
Pavlov. Cond. lever contacts0.70.81.1-1.0-0.8-0.7-1.0-0.7-1.0-1.01.1-1.0-1.0-0.9-0.81.10.7-0.9
Pavlov. Cond. magazine entry number1.62.03.11.80.91.01.60.91.51.5-1.71.61.51.31.6-1.7-0.51.7
Pavlov. Cond. intertrial magazine entries0.20.21.50.2-0.10.00.30.10.30.3-0.60.30.40.20.2-0.90.01.2
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.7-0.5-0.5-0.7-0.4-0.7-0.70.8-0.7-0.7-0.7-0.60.80.4-0.7
Pavlov. Cond. response bias1.31.62.3-1.5-1.0-0.9-1.4-0.9-1.3-1.41.5-1.4-1.4-1.2-1.31.50.7-1.4
Pavlov. Cond. lever latency1.82.52.91.51.71.71.51.61.71.6-1.61.61.61.71.6-1.4-1.61.1
Pavlov. Cond. magazine entry latency0.60.71.0-0.9-1.0-1.0-0.7-1.0-0.9-0.90.8-0.8-0.8-0.9-0.80.60.9-0.3
Pavlov. Cond. change in total contacts0.81.32.1-0.7-1.3-1.3-1.0-1.3-1.2-1.11.0-1.0-1.2-1.3-1.01.11.4-0.9
Pavlov. Cond. index score1.82.43.1-1.6-1.7-1.8-1.5-1.8-1.6-1.61.5-1.6-1.5-1.6-1.61.31.6-0.8
Pavlov. Cond. latency score2.02.63.6-1.5-1.9-1.9-1.5-1.9-1.7-1.61.5-1.5-1.6-1.8-1.61.41.9-0.9
Pavlov. Cond. lever contacts2.53.44.1-1.8-2.0-2.0-1.8-2.0-2.0-1.91.8-1.9-1.9-2.0-1.81.61.9-1.1
Pavlov. Cond. magazine entry number0.70.81.00.91.01.00.81.01.01.0-0.91.00.91.01.0-0.8-0.80.5
Pavlov. Cond. intertrial magazine entries0.10.10.6-0.10.50.50.10.50.20.2-0.20.00.30.50.1-0.4-0.80.3
Pavlov. Cond. lever-magazine prob. diff.1.62.12.6-1.5-1.6-1.6-1.4-1.6-1.5-1.51.4-1.5-1.4-1.5-1.51.21.4-0.8
Pavlov. Cond. response bias2.33.13.7-1.9-1.8-1.8-1.7-1.8-1.9-1.91.9-1.9-1.8-1.8-1.91.71.5-1.3
Time in closed arm before self-admin3.54.58.4-2.9-1.8-2.0-2.3-2.2-2.2-2.22.0-2.4-2.1-2.0-2.41.91.4-1.4
Time in closed arm after self-admin0.91.04.2-2.0-0.8-0.9-1.3-0.9-1.0-1.00.9-1.0-0.9-0.8-0.90.80.4-0.2
Time in open arm before self-admin5.56.07.02.62.22.42.42.42.52.5-2.62.52.52.42.6-2.6-2.02.2
Time in open arm after self-admin3.63.97.62.81.11.42.51.72.02.2-2.22.42.01.52.4-2.0-0.31.8
Bone: periosteal estimation0.00.00.1-0.30.10.3-0.30.2-0.1-0.10.1-0.2-0.10.0-0.00.2-0.2-0.2
Bone: periosteal perimeter1.11.92.8-0.9-1.3-1.3-1.4-1.5-1.4-1.41.4-1.3-1.5-1.5-1.01.71.5-1.6
Bone: post-yield work0.00.10.20.5-0.3-0.00.3-0.00.10.2-0.10.40.1-0.20.2-0.00.40.2
Progressive ratio test 1 active lever presses3.13.85.3-1.2-2.1-2.2-1.9-2.3-2.0-1.92.0-1.7-2.1-2.0-1.52.22.0-1.9
Progressive ratio test 1 breakpoint3.34.15.5-1.2-2.1-2.2-2.0-2.3-2.0-2.02.1-1.8-2.1-2.1-1.62.32.0-2.1
Progressive ratio test 1 inactive lever presses1.01.41.8-1.1-1.2-1.2-1.2-1.2-1.3-1.31.2-1.3-1.3-1.2-1.21.20.8-0.8
Progressive ratio test 2 active lever presses5.46.48.8-2.4-2.7-2.8-2.6-3.0-2.6-2.62.6-2.5-2.6-2.5-2.22.42.3-1.7
Progressive ratio test 2 breakpoint5.76.69.1-2.4-2.8-2.9-2.7-3.0-2.7-2.62.6-2.5-2.6-2.6-2.22.52.4-1.8
Progressive ratio test 2 inactive lever presses3.04.87.0-2.6-2.3-2.2-2.4-2.2-2.4-2.32.2-2.4-2.2-2.0-2.41.91.5-1.2
Incentive Sensitization - Responses3.24.66.7-2.3-2.2-2.4-2.3-2.6-2.2-2.22.0-2.2-2.1-2.1-2.11.82.0-1.2
Incentive Sensitization - Breakpoint3.24.16.1-2.2-2.2-2.4-2.2-2.5-2.1-2.11.9-2.0-2.0-2.0-1.91.72.0-1.0
Sum of active levers in priming session hrs 5-60.80.81.61.01.31.30.81.20.90.7-0.50.60.70.90.7-0.2-1.0-0.7
Progressive ratio0.50.71.2-0.6-0.8-0.6-0.8-0.4-0.9-1.01.1-1.0-1.0-1.0-0.91.10.4-1.1
Food seeking constrained by brief footshock0.60.71.8-0.5-1.1-1.0-0.7-0.9-0.8-0.80.8-0.6-0.8-1.0-0.90.81.3-0.6
Seeking ratio, punishment vs. effort0.30.41.30.50.20.20.60.20.60.7-0.90.90.70.50.8-0.80.21.2
Retroperitoneal fat weight10.544.875.0-8.7-7.0-6.8-7.4-6.6-7.3-7.16.7-7.2-6.7-6.6-7.05.55.1-2.8
Reaction time number correct0.00.00.10.10.00.1-0.10.00.0-0.00.00.0-0.1-0.1-0.20.20.1-0.3
Reaction time mean minus median0.10.31.50.2-0.4-0.3-0.3-0.2-0.4-0.50.6-0.4-0.5-0.6-0.40.90.6-1.2
Reaction time mean minus median AUC0.10.41.50.1-0.5-0.3-0.4-0.2-0.5-0.60.7-0.6-0.6-0.7-0.60.90.6-1.2
Reaction time num false alarms1.72.44.32.11.41.51.71.51.71.7-1.61.81.51.41.7-1.4-1.01.1
Reaction time num false alarms AUC2.03.15.42.31.71.71.91.71.91.9-1.72.01.71.71.9-1.5-1.31.1
Reaction time trials correct on left0.00.00.10.10.00.1-0.10.00.0-0.00.00.0-0.1-0.1-0.20.20.1-0.3
Reaction time trials on left0.00.00.10.10.10.2-0.00.10.10.1-0.00.1-0.00.0-0.20.1-0.0-0.3
Reaction time mean0.60.91.8-0.6-0.6-0.7-0.9-0.7-0.9-1.01.0-1.2-0.9-0.8-1.21.00.5-1.4
Reaction time mean AUC0.91.42.6-0.8-0.8-0.9-1.2-0.9-1.2-1.31.3-1.5-1.2-1.1-1.61.30.7-1.6
Median of all reaction times0.91.22.4-0.9-0.6-0.9-1.2-0.9-1.1-1.21.2-1.4-1.1-1.0-1.51.10.6-1.4
Reaction time omissions0.50.82.10.31.21.10.71.10.80.8-0.70.50.91.00.3-0.9-1.40.6
Reaction time false alarm rate2.73.75.02.21.81.82.11.82.02.0-1.92.12.01.92.1-1.8-1.51.6
Reaction time premature initiation rate0.10.10.50.50.50.40.30.30.20.10.10.20.00.10.10.3-0.6-0.7
Reaction time premature initiations0.10.10.70.60.50.40.30.30.20.10.10.20.00.10.00.4-0.5-0.8
Std. dev. reaction times0.10.31.1-0.1-0.3-0.2-0.4-0.1-0.5-0.50.6-0.7-0.5-0.5-0.60.70.2-1.1
Reaction time trials completed0.00.00.10.10.10.2-0.00.10.10.1-0.00.1-0.00.0-0.20.1-0.0-0.3
Reaction time trials AUC0.00.00.20.0-0.0-0.0-0.2-0.1-0.1-0.10.2-0.1-0.2-0.2-0.30.30.2-0.5
Run reversals in cocaine runway, females0.80.82.2-1.5-0.3-0.6-1.1-0.7-0.9-1.00.9-1.3-0.7-0.4-1.30.5-0.2-0.3
Run reversals in cocaine runway, males3.53.59.60.22.22.11.42.11.61.5-1.51.11.82.21.3-2.1-3.12.0
Latency to leave start box in cocaine runway0.70.71.60.80.71.11.01.30.80.9-0.90.90.90.70.9-0.8-0.20.7
Latency to leave start box in cocaine runway, F0.30.30.90.80.30.70.80.90.50.5-0.50.60.50.30.6-0.50.30.3
Latency to leave start box in cocaine runway, M0.30.30.6-0.00.60.80.30.70.50.5-0.50.40.50.60.5-0.5-0.70.4
Std. dev. time between licks in bursts0.10.20.9-0.30.50.50.30.50.30.2-0.20.10.40.40.1-0.4-0.90.6
Total sessions with >9 infusions1.72.03.5-0.9-1.6-1.8-1.4-1.9-1.4-1.41.4-1.2-1.5-1.5-1.01.51.5-1.0
Short access day 1 total inactive lever presses0.60.81.2-0.3-1.1-1.1-0.8-1.0-1.0-1.00.8-0.9-0.9-1.0-1.00.61.1-0.2
Short access day 10 total inactive lever presses0.20.41.9-0.8-0.10.0-0.40.2-0.6-0.70.6-1.0-0.5-0.4-1.40.4-0.0-0.6
Short access day 1 total infusions3.64.76.0-1.6-2.1-2.3-2.4-2.4-2.3-2.32.2-2.2-2.3-2.2-2.22.31.9-1.9
Short access day 10 total infusions2.02.64.9-1.2-2.2-2.2-1.6-2.2-1.6-1.41.4-1.1-1.6-1.7-1.01.42.0-0.7
Short access total infusions3.24.16.3-1.3-2.2-2.4-2.1-2.5-2.0-2.02.0-1.8-2.1-2.1-1.72.12.2-1.7
Short access day 1 locomotion1.51.93.8-1.0-1.9-1.9-1.1-1.8-1.3-1.21.2-0.9-1.3-1.5-0.61.22.0-0.5
Short access day 10 total locomotion1.42.65.1-1.4-2.3-1.9-1.4-1.7-1.7-1.61.6-1.5-1.6-1.7-1.41.41.8-0.7
Short access total locomotion1.92.34.6-1.1-2.1-1.9-1.3-1.8-1.5-1.41.3-1.2-1.5-1.6-1.11.31.9-0.7
One hour access (0.3 mA shock)3.64.15.7-1.9-2.4-2.4-1.9-2.4-2.1-2.02.0-1.9-2.0-2.0-1.81.92.0-1.3
Compulsive drug intake4.04.86.02.22.32.52.32.52.22.1-2.31.92.22.21.6-2.3-2.31.8
One hour access (shock baseline)5.88.811.9-2.7-3.4-3.4-3.0-3.4-3.0-2.93.0-2.6-3.0-3.1-2.23.03.2-2.3
Social response proportion2.93.35.31.82.32.21.82.21.81.7-1.71.41.82.00.9-1.7-2.31.0
Social responses0.40.52.80.6-0.1-0.1-0.2-0.0-0.4-0.50.8-0.4-0.6-0.5-0.81.00.4-1.7
Social time2.02.76.82.61.61.51.81.51.81.7-1.71.81.61.51.5-1.4-0.80.8
Soleus weight1.44.06.90.42.12.01.62.01.91.9-2.11.62.22.31.5-2.5-2.42.6
Bone: stiffness0.71.11.6-1.0-1.0-0.8-1.0-0.8-1.2-1.21.3-1.1-1.2-1.1-1.21.20.7-1.1
Tibialis anterior weight2.06.99.71.93.12.82.52.72.72.6-2.52.42.73.02.5-2.5-3.11.9
Time to tail flick, vehicle, before self-admin1.21.33.6-0.4-1.4-1.3-0.7-1.2-1.1-1.01.0-0.8-1.1-1.4-0.71.21.9-0.9
Time to tail flick, vehicle, after self-admin3.14.16.6-2.0-2.3-2.5-2.1-2.6-2.1-2.01.9-1.8-2.0-2.1-1.51.82.4-1.0
Time to tail flick, test, before self-admin1.81.93.0-1.7-1.7-1.4-1.3-1.3-1.4-1.31.4-1.2-1.4-1.5-1.11.31.6-0.9
Time to tail flick, test, after self-admin3.63.88.1-1.7-2.6-2.2-1.7-1.9-1.9-1.81.7-1.6-1.9-2.3-1.51.62.9-1.0
Delta time to tail flick, vehicle, before/after SA0.30.31.2-1.1-0.5-0.6-0.7-0.8-0.5-0.50.4-0.6-0.4-0.2-0.4-0.00.10.5
Delta time to tail flick, test, before/after SA0.10.10.70.7-0.3-0.40.2-0.40.10.1-0.30.40.0-0.20.2-0.20.80.4
Tibia length0.10.31.4-0.10.80.8-0.20.70.1-0.10.2-0.3-0.10.3-0.20.4-0.9-1.2
Ambulatory time before self-admin0.10.10.5-0.70.30.30.00.30.10.00.1-0.00.10.40.0-0.0-0.70.1
Ambulatory time after self-admin1.31.65.0-1.3-0.5-0.6-1.2-0.6-1.1-1.21.7-1.3-1.3-0.9-1.01.9-0.1-2.2
Bone: tissue strength0.20.20.80.90.00.30.70.50.40.5-0.50.60.40.20.6-0.40.10.3
Total heroin consumption0.50.61.80.41.31.00.60.90.70.6-0.50.40.71.00.7-0.5-1.4-0.2
Bone: trabecular number0.30.61.1-0.9-1.0-1.0-0.8-0.9-0.8-0.70.6-0.7-0.7-0.8-0.40.40.80.1
Bone: trabecular spacing0.20.31.10.1-0.3-0.3-0.3-0.3-0.4-0.40.6-0.3-0.5-0.5-0.50.80.5-1.0
Bone: trabecular thickness0.40.50.9-0.9-0.8-0.8-0.7-0.7-0.8-0.70.7-0.8-0.7-0.7-0.60.50.7-0.2
Bone: trabecular tissue density0.81.22.60.51.21.51.01.61.00.9-0.90.71.11.10.5-1.1-1.30.8
Water consumed over 24 hours0.71.01.7-1.3-0.8-0.9-1.1-0.9-1.1-1.11.1-1.1-1.0-0.9-1.11.00.5-0.8
Number of responses in last shaping day3.84.15.1-1.8-1.8-2.0-2.1-2.1-2.2-2.22.3-2.2-2.2-2.0-2.02.11.5-1.7