Hub : Genes

C2cd4c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	isoform ratio	NM_001109285.1	0.11	0.09	7.0e-03	0.05	0.05	0.02	0.04	2.3e-02	2.5e-02	1.1e-01	3.9e-02
2	LHb	isoform ratio	XM_006240985.4	0.1	0.09	8.9e-03	0.06	0.05	0.02	0.04	1.7e-02	2.7e-02	8.8e-02	3.3e-02
3	Brain	isoform ratio	XM_006240985.4	0.08	0.06	8.4e-07	0.07	0.06	0.07	0.07	4.7e-07	1.1e-06	4.7e-07	7.0e-07
4	PL	isoform ratio	XM_006240985.4	0.06	0.04	1.3e-08	0.09	0.07	0.08	0.08	1.0e-09	2.8e-08	6.7e-09	4.6e-09
5	PL	isoform ratio	NM_001109285.1	0.06	0.04	7.5e-09	0.08	0.07	0.08	0.08	4.3e-09	1.2e-08	3.4e-09	2.3e-09
6	Brain	gene expression	C2cd4c	0.06	0.05	2.6e-06	0.05	0.05	0.05	0.05	1.5e-05	1.5e-05	3.0e-05	2.6e-05
7	Brain	isoform ratio	NM_001109285.1	0.08	0.06	8.3e-07	0.07	0.07	0.07	0.07	4.6e-07	1.0e-06	3.9e-07	6.4e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.8	1.4	5.2	-0.9	0.9	-1.0	-0.9	-0.9	0.7	2.3
Area under the delay curve	2.1	2.2	2.9	1.7	-1.7	-1.6	-1.3	-1.3	1.6	1.0
BMI with tail	5.9	19.2	22.4	4.7	-4.7	-4.6	-4.5	-4.5	4.6	2.7
BMI without tail	1.9	3.9	7.2	2.7	-2.7	-1.8	-1.8	-1.8	1.7	0.1
Body weight	0.9	4.0	5.4	2.3	-2.3	-2.1	-1.8	-1.9	2.1	1.1
Weight adjusted by age	0.6	0.7	1.7	1.3	-1.3	-0.5	-0.6	-0.6	0.5	-0.4
Bone surface	1.1	2.0	6.3	-1.8	1.8	-0.5	-0.4	-0.5	0.3	2.5
Bone volume	1.1	1.9	6.5	-1.7	1.7	-0.6	-0.6	-0.6	0.4	2.6
Breakpoint value in progressive ratio session	5.2	5.7	7.0	-2.1	2.1	2.6	2.5	2.5	-2.6	-2.1
Number of licking bursts	0.3	0.3	0.7	0.9	-0.9	0.1	0.0	0.1	0.0	-0.9
Context. condit. distance diff. score	0.1	0.1	0.4	0.3	-0.3	-0.0	-0.0	-0.0	0.0	-0.6
Locomotion velocity, session 1	0.5	0.5	1.5	-1.2	1.2	0.3	0.3	0.3	-0.4	0.7
Locomotion distance, session 1	0.9	1.2	3.8	-1.9	1.9	0.3	0.3	0.3	-0.3	0.7
Locomotion velocity, session 2	5.0	5.9	11.5	-3.4	3.4	2.1	2.1	2.1	-2.0	-0.6
Locomotion distance, session 2	1.7	2.4	6.5	-2.5	2.5	0.8	0.8	0.8	-0.8	1.1
Locomotion velocity, session 3	7.3	8.5	9.9	-2.7	2.7	3.1	3.1	3.1	-2.9	-2.5
Locomotion distance, session 3	0.1	0.1	0.4	-0.0	0.0	0.3	0.3	0.3	-0.1	-0.6
Stereotopy head waving bouts, day 3	5.9	7.0	8.8	-3.0	3.0	2.7	2.7	2.7	-2.4	-1.6
Stereotopy head waving duration, day 3	6.4	7.7	8.6	-2.9	2.9	2.9	2.9	2.9	-2.7	-1.9
Locomotion velocity, session 7	1.6	1.7	3.3	-1.0	1.0	1.4	1.4	1.4	-1.0	-1.8
Locomotion distance, session 7	0.2	0.3	0.9	0.7	-0.7	0.0	0.0	0.0	0.1	-1.0
Stereotopy head waving bouts, day 7	0.2	0.3	0.8	-0.9	0.9	0.1	0.1	0.1	-0.0	0.4
Stereotopy head waving duration, day 7	0.4	0.5	1.5	-1.2	1.2	0.3	0.3	0.3	-0.2	0.5
Locomotion velocity, session 8	1.3	1.6	4.1	-2.0	2.0	1.0	1.0	1.0	-0.5	-0.1
Locomotion distance, session 8	0.5	0.7	1.6	-1.3	1.3	0.6	0.6	0.6	-0.6	-0.2
Degree of sensitization distance	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.5	-0.5	0.5	0.0
Degree of sensitization stereotypy	1.7	1.9	2.5	0.9	-0.9	-1.6	-1.6	-1.6	1.5	1.5
Conditioned locomotion	1.3	1.5	3.1	1.7	-1.7	-1.0	-1.0	-1.0	1.1	-0.3
Cocaine response after cond. corrected	5.4	6.1	11.6	3.4	-3.4	-2.3	-2.2	-2.2	2.0	0.4
Cocaine response after cond. not corrected	5.4	5.9	11.5	3.4	-3.4	-2.2	-2.2	-2.2	2.0	0.3
Cocaine response before conditioning	0.8	0.9	1.2	-1.1	1.1	1.0	1.0	1.0	-0.8	-0.7
Saline control response	0.0	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.2	0.3	0.0
Bone: connectivity density	0.8	1.3	4.1	-0.3	0.3	-1.1	-1.1	-1.1	1.0	2.0
Bone: cortical apparent density	1.5	2.0	2.2	1.5	-1.5	-1.4	-1.4	-1.4	1.3	1.3
Bone: cortical area	0.5	0.8	1.2	0.4	-0.4	-1.0	-1.0	-1.0	1.1	1.0
Bone: cortical porosity	0.5	0.5	1.2	-1.1	1.1	0.5	0.5	0.5	-0.5	0.1
Bone: cortical porosity	0.3	0.3	0.8	-0.9	0.9	-0.1	-0.1	-0.1	0.2	0.7
Bone: cortical thickness	1.2	1.9	2.5	1.0	-1.0	-1.5	-1.5	-1.5	1.6	1.4
Bone: cortical thickness	0.2	0.3	0.6	0.8	-0.8	0.1	0.0	0.0	-0.2	-0.7
Bone: cortical tissue density	1.1	1.5	1.8	1.3	-1.3	-1.2	-1.2	-1.2	1.1	1.2
Condit. Reinf. active minus inactive responses	5.0	5.6	6.1	-2.4	2.4	2.5	2.5	2.5	-2.5	-1.7
Condit. Reinf. active-inactive response ratio	1.8	2.0	3.1	-1.0	1.0	1.5	1.5	1.5	-1.8	-1.2
Condit. Reinf. active responses	4.3	5.2	8.6	-2.9	2.9	2.2	2.2	2.2	-2.2	-1.0
Condit. Reinf. inactive responses	1.3	1.6	4.3	-2.1	2.1	0.8	0.8	0.8	-0.7	0.2
Incentive salience index mean	3.1	3.7	5.9	-2.4	2.4	1.8	1.8	1.8	-1.8	-0.9
Condit. Reinf. lever presses	0.6	0.8	2.1	-1.4	1.4	-0.2	-0.2	-0.2	0.2	1.2
Condit. Reinf. active minus inactive responses	1.5	1.9	2.5	-0.8	0.8	1.6	1.5	1.5	-1.5	-1.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.6	0.8	-0.8	-0.1	-0.2	-0.2	-0.0	-0.1
Condit. Reinf. active responses	1.5	2.1	2.8	-1.0	1.0	1.7	1.6	1.6	-1.5	-1.5
Condit. Reinf. inactive responses	1.4	1.7	2.2	-1.0	1.0	1.5	1.5	1.5	-1.2	-1.5
Condit. Reinf. lever presses	1.9	2.5	3.3	-1.2	1.2	1.7	1.7	1.7	-1.8	-1.6
Condit. Reinf. lever reinforcers received	1.1	1.6	2.3	-0.7	0.7	1.5	1.4	1.4	-1.3	-1.5
Conditioned reinforcement - actives	1.8	1.8	2.7	-1.6	1.6	1.3	1.3	1.3	-1.4	-0.7
Conditioned reinforcement - inactives	0.2	0.3	0.6	0.8	-0.8	-0.6	-0.2	-0.2	0.5	-0.1
Conditioned locomotion	6.6	7.9	9.3	-3.0	3.0	2.8	3.0	3.0	-2.9	-1.8
Patch foraging indifference point 0 sec	0.2	0.4	0.6	0.3	-0.3	-0.7	-0.7	-0.7	0.7	0.8
Patch foraging indifference point AUC	0.5	0.6	0.9	-0.8	0.8	0.8	0.8	0.8	-1.0	-0.5
Delay disc. indifference point, 0s delay	7.5	8.2	11.1	1.7	-1.7	-3.2	-3.2	-3.2	3.2	3.3
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.6	-0.6	-0.4	-0.1	-0.1	0.4	0.3
Delay disc. indifference point, 2s delay	4.8	5.3	6.9	2.1	-2.1	-2.6	-2.3	-2.3	2.6	2.0
Delay disc. indifference point, 24s delay	0.9	0.9	1.7	1.3	-1.3	-1.0	-0.6	-0.6	0.9	0.5
Delay disc. indifference point, 4s delay	0.7	0.7	1.1	0.8	-0.8	-1.0	-0.6	-0.7	1.0	0.8
Delay disc. indifference point, 8s delay	1.3	1.3	2.5	1.6	-1.6	-1.0	-1.0	-1.0	1.0	0.1
Indifference point function ln k	0.2	0.3	0.6	0.8	-0.8	-0.5	-0.5	-0.5	0.5	-0.0
Indifference point function log k	0.2	0.3	0.6	0.8	-0.8	-0.5	-0.5	-0.5	0.5	-0.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	0.3	-0.3	-0.5	-0.5	-0.5	0.6	0.4
Patch foraging total patch changes 12 sec	0.3	0.4	0.7	0.8	-0.8	-0.7	-0.7	-0.7	0.4	0.2
Patch foraging total patch changes 18 sec	0.9	1.1	1.4	-1.2	1.2	1.1	1.0	1.0	-1.2	-0.6
Patch foraging total patch changes 24 sec	0.0	0.0	0.2	-0.2	0.2	0.0	0.0	0.0	-0.1	0.4
Patch foraging total patch changes 6 sec	0.1	0.1	0.2	-0.5	0.5	0.1	-0.1	-0.1	-0.2	0.4
Patch foraging time to switch 0 sec	1.0	1.5	3.2	-0.1	0.1	-1.3	-1.4	-1.4	1.2	1.8
Patch foraging water rate 0 sec	0.5	0.9	3.0	1.1	-1.1	0.5	0.5	0.5	-0.2	-1.7
Patch foraging water rate 12 sec	1.4	2.1	5.7	2.4	-2.4	-0.9	-0.8	-0.8	1.0	-0.7
Patch foraging water rate 18 sec	1.1	1.5	5.0	1.4	-1.4	0.7	0.7	0.7	-0.7	-2.2
Patch foraging water rate 24 sec	1.1	1.6	4.1	2.0	-2.0	-0.1	0.0	0.0	0.2	-1.7
Patch foraging water rate 6 sec	0.7	1.1	3.7	0.7	-0.7	0.9	0.8	0.8	-0.8	-1.9
Seeking ratio, delayed vs. immediate footshock	3.9	4.5	6.1	-2.2	2.2	2.1	2.5	2.4	-2.1	-1.0
Distance traveled before self-admin	1.1	1.1	2.0	0.7	-0.7	-1.0	-1.4	-1.4	0.9	1.1
Distance traveled after self-admin	0.3	0.4	0.7	-0.8	0.8	0.7	0.3	0.3	-0.7	-0.2
Extensor digitorum longus weight	3.4	13.4	20.5	4.5	-4.5	-3.6	-3.5	-3.5	3.8	1.0
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.2	0.0	0.0	0.0	-0.4	0.4
Bone: elastic work	0.5	0.6	0.8	0.7	-0.7	-0.9	-0.9	-0.9	0.5	0.8
Bone: endosteal estimation	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	-0.3	0.4	0.0
Bone: endosteal perimeter	0.3	0.7	1.3	-1.1	1.1	0.7	0.8	0.8	-0.7	-0.3
Epididymis fat weight	0.2	0.5	0.9	-0.7	0.7	0.8	0.7	0.7	-0.9	-0.6
Delta time in closed arm before/after self-admin	1.3	1.2	3.2	1.8	-1.8	-0.5	-0.7	-0.7	0.4	-0.8
Delta time in open arm before/after self-admin	1.5	1.5	1.9	0.9	-0.9	-1.4	-1.3	-1.3	1.1	1.4
Diff in mean of infusions in LGA sessions	1.9	2.1	2.5	-1.5	1.5	1.6	1.5	1.4	-1.6	-1.0
Delay discount exponential model param	1.9	2.0	2.8	-1.7	1.7	1.5	1.2	1.2	-1.5	-0.9
Extinction: sum of active levers before priming	1.4	1.4	1.9	-0.8	0.8	1.3	1.4	1.4	-1.3	-1.4
Active lever presses in extinction session 6	1.9	1.8	2.5	-1.5	1.5	1.6	1.2	1.2	-1.5	-0.9
Bone: final force	1.0	1.6	2.3	1.1	-1.1	-1.4	-1.4	-1.4	1.5	0.8
Bone: final moment	0.8	1.3	1.8	1.0	-1.0	-1.3	-1.3	-1.3	1.3	0.8
Food consumed during 24 hour testing period	0.7	0.8	1.9	1.4	-1.4	-0.8	-0.7	-0.7	0.7	0.2
Glucose	1.8	2.7	3.4	1.8	-1.8	-1.6	-1.6	-1.6	1.8	1.1
Heart weight	0.1	0.1	0.2	0.0	-0.0	0.4	0.0	0.0	-0.5	-0.3
Delay discount hyperbolic model param	2.6	2.8	3.5	-1.9	1.9	1.8	1.5	1.5	-1.8	-1.1
Intermittent access intake day 1-15 change	5.5	5.4	7.3	-2.3	2.3	2.7	2.0	2.0	-2.6	-2.1
Intermittent access intake escalation	5.2	5.1	7.4	-1.9	1.9	2.7	1.9	2.0	-2.7	-2.6
Intermittent access intake escalation 2	6.1	6.0	8.7	-2.1	2.1	2.9	2.0	2.1	-2.9	-2.7
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.7	0.1	-0.1	0.4	0.3	0.3	-0.5	-0.8
Intermitt. access day 15 inactive lever presses	0.6	0.6	0.9	-0.6	0.6	0.9	0.8	0.8	-0.8	-0.9
Intermitt. access escalation Index	0.4	0.3	1.1	0.0	-0.0	-0.6	-0.4	-0.4	0.6	1.1
Intermittent access day 1 total infusions	0.0	0.0	0.1	0.1	-0.1	-0.2	0.3	0.3	0.2	0.2
Intermittent access day 15 total infusions	2.0	2.3	2.8	-1.1	1.1	1.7	1.6	1.6	-1.6	-1.6
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.4	-1.0	1.0	1.2	1.2	1.2	-1.1	-1.1
Intermittent access total infusions	0.4	0.4	0.7	-0.3	0.3	0.6	0.8	0.8	-0.5	-0.7
Intermittent access day 1 locomotion	0.6	0.6	1.1	-0.5	0.5	0.8	1.0	1.0	-0.8	-0.7
Intermittent access day 15 total locomotion	3.7	4.0	5.3	-1.9	1.9	2.0	2.3	2.3	-2.1	-1.4
Intermittent access total locomotion	1.1	1.2	1.9	-1.1	1.1	1.0	1.4	1.3	-1.0	-0.6
Intermittent access standard deviation	2.7	2.8	3.5	-1.3	1.3	1.8	1.9	1.9	-1.8	-1.7
Left kidney weight	0.0	0.0	0.1	-0.3	0.3	0.1	-0.1	-0.1	-0.2	0.3
Right kidney weight	1.0	2.9	4.8	-1.8	1.8	1.9	1.4	1.5	-2.2	-1.2
Cocaine induced anxiety	0.5	0.6	1.5	-1.2	1.2	0.4	0.4	0.4	-0.4	0.5
Post-drug Anxiety	0.6	0.6	1.6	-1.3	1.3	0.5	0.6	0.6	-0.5	0.4
Baseline Anxiety	0.4	0.4	1.0	-0.0	0.0	0.6	0.7	0.7	-0.6	-1.0
Tail length	3.3	9.9	12.0	-2.8	2.8	3.4	3.3	3.3	-3.5	-2.8
Length with tail	1.8	6.6	7.5	-2.7	2.7	2.6	2.7	2.7	-2.7	-1.6
Length without tail	0.2	0.3	0.9	-1.0	1.0	0.1	0.3	0.3	-0.0	0.6
Times rat made contact with spout	0.4	0.4	1.3	1.1	-1.1	-0.2	-0.2	-0.2	0.4	-0.4
Lifetime Intake	0.2	0.2	0.4	-0.2	0.2	0.4	0.6	0.6	-0.3	-0.5
Liver weight, left	1.7	2.7	3.5	1.9	-1.9	-1.7	-1.7	-1.7	1.7	0.9
Liver weight, right	1.1	1.8	2.6	1.2	-1.2	-1.4	-1.6	-1.6	1.4	0.8
Locomotor activity	2.7	4.3	7.2	-2.7	2.7	1.9	2.1	2.0	-1.8	-0.7
Locomotor testing distance	1.4	2.3	3.8	-2.0	2.0	1.4	1.4	1.4	-1.5	-0.4
Locomotor testing rearing	0.1	0.2	0.6	0.3	-0.3	0.3	0.3	0.3	-0.2	-0.8
Locomotion in novel chamber	0.1	0.1	0.3	0.2	-0.2	0.4	0.1	0.1	-0.4	-0.5
Locomotion in novel chamber post-restriction	1.2	1.5	2.2	-0.8	0.8	1.3	1.3	1.3	-1.2	-1.5
Fecal boli incidents, locomotor time 1	1.2	1.3	2.0	1.4	-1.4	-1.2	-1.0	-1.1	1.2	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.4	0.4	0.2	0.3	0.3	-0.1	-0.1
Time >=10cm from walls, locomotor time 1	1.5	1.5	2.6	0.5	-0.5	-1.1	-1.6	-1.6	1.2	1.4
Bouts of movement, locomotor time 1	0.5	0.5	1.0	-0.3	0.3	0.7	1.0	1.0	-0.6	-0.9
Total resting periods, locomotor time 1	0.6	0.6	1.0	-0.5	0.5	0.8	1.0	1.0	-0.7	-0.9
Rest time, locomotor task time 1	0.8	0.8	1.0	-1.0	1.0	0.9	0.9	0.9	-0.8	-0.8
Distance moved, locomotor task time 1	1.4	1.5	2.7	0.6	-0.6	-1.3	-1.5	-1.5	1.2	1.6
Vertical activity count, locomotor time 1	0.8	0.8	1.5	1.2	-1.2	-0.7	-0.9	-0.9	0.7	0.4
Time >=10cm from walls, locomotor time 2	1.7	1.8	2.7	1.6	-1.6	-1.3	-1.4	-1.4	1.3	0.4
Bouts of movement, locomotor time 2	0.5	0.6	1.3	-1.1	1.1	0.5	0.6	0.6	-0.6	0.4
Total resting periods, locomotor time 2	0.5	0.5	1.3	-1.1	1.1	0.5	0.5	0.5	-0.5	0.5
Rest time, locomotor task time 2	0.5	0.5	0.9	-1.0	1.0	0.7	0.6	0.6	-0.8	-0.1
Distance moved, locomotor task time 2	0.5	0.6	0.9	0.9	-0.9	-0.8	-0.8	-0.8	0.8	0.2
Vertical activity count, locomotor time 2	0.6	0.7	1.4	1.2	-1.2	-0.6	-0.7	-0.7	0.6	-0.5
Light reinforcement 1	5.9	10.7	13.9	-3.7	3.7	3.1	3.6	3.5	-3.2	-1.3
Light reinforcement 2	2.0	2.7	4.1	-2.0	2.0	1.3	1.9	1.8	-1.4	-0.1
Bone: marrow area	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	-0.3	0.4	0.0
Bone: maximum diameter	0.7	1.3	2.7	-1.6	1.6	1.0	1.0	1.0	-0.9	-0.1
Bone: maximum force	0.9	1.6	2.0	1.2	-1.2	-1.3	-1.4	-1.4	1.4	0.6
Bone: maximum moment	0.8	1.4	1.6	1.2	-1.2	-1.3	-1.3	-1.3	1.3	0.7
Mean time between licks in bursts	3.7	5.2	6.3	-2.2	2.2	2.5	2.5	2.5	-2.2	-1.8
Mean num. licks in bursts	0.0	0.0	0.2	0.1	-0.1	-0.2	-0.2	-0.2	0.1	0.4
Cd content in liver	0.3	0.4	0.9	0.5	-0.5	-0.6	-0.6	-0.6	0.9	0.5
Co content in liver	0.8	0.9	1.1	-0.9	0.9	1.0	1.0	1.0	-0.9	-1.0
Cu content in liver	0.1	0.1	0.3	-0.3	0.3	-0.3	-0.3	-0.3	0.5	0.5
Fe content in liver	0.4	0.5	1.4	-0.6	0.6	0.7	0.7	0.7	-0.5	-1.2
K content in liver	0.4	0.4	1.2	-1.1	1.1	0.2	0.2	0.3	0.3	0.1
Mg content in liver	0.3	0.3	0.8	-0.9	0.9	-0.0	-0.0	-0.0	0.4	0.5
Mn content in liver	1.8	2.1	5.5	-2.3	2.3	1.0	1.0	1.0	-0.7	0.0
Na content in liver	0.4	0.4	1.0	-0.4	0.4	-0.6	-0.6	-0.6	1.0	0.5
Rb content in liver	0.5	0.6	1.4	-0.1	0.1	-0.8	-0.8	-0.8	1.0	1.2
Se content in liver	0.9	1.1	1.3	-1.1	1.1	1.0	1.0	1.0	-0.9	-1.1
Sr content in liver	0.2	0.2	0.6	0.4	-0.4	0.3	0.3	0.3	-0.3	-0.8
Zn content in liver	1.5	1.7	2.8	-0.3	0.3	1.5	1.5	1.5	-1.7	-1.6
Bone: minimum diameter	0.0	0.1	0.2	-0.4	0.4	0.2	0.2	0.2	0.0	-0.3
Time in familiar zone, hab. session 1	2.1	2.0	3.3	-1.0	1.0	1.5	1.5	1.5	-1.8	-1.3
Time in novel zone, hab. session 1	1.2	1.2	1.9	0.6	-0.6	-1.2	-1.2	-1.2	1.4	1.3
Total zone transitions, hab. session 1	1.2	1.6	4.0	-2.0	2.0	1.0	1.0	1.0	-0.7	0.2
Total locomotion distance, hab. session 1	1.8	2.6	6.6	-2.6	2.6	1.2	1.2	1.2	-0.9	0.0
Locomotion velocity, hab. session 1	2.4	3.4	7.6	-2.8	2.8	1.5	1.5	1.5	-1.2	-0.2
Time in familiar zone, hab. session 2	5.2	5.4	8.6	-1.6	1.6	2.6	2.6	2.6	-2.9	-1.9
Time in novel zone, hab. session 2	4.6	4.6	6.2	1.8	-1.8	-2.3	-2.3	-2.3	2.5	1.9
Total zone transitions, hab. session 2	0.7	0.9	3.3	-0.8	0.8	-0.6	-0.6	-0.6	0.8	1.8
Total locomotion distance, hab. session 2	1.1	1.5	3.4	-1.9	1.9	0.9	0.9	0.9	-0.9	0.5
Locomotion velocity, hab. session 2	1.2	1.6	3.9	-2.0	2.0	0.8	0.8	0.8	-0.8	0.8
Novel to familiar place preference ratio	4.5	4.6	6.2	1.4	-1.4	-2.4	-2.4	-2.4	2.5	2.3
Novelty place preference	2.9	2.9	3.8	1.0	-1.0	-1.9	-1.9	-1.9	1.9	1.9
Time in novel zone, NPP test	2.9	3.0	3.9	1.2	-1.2	-1.9	-1.9	-1.9	2.0	1.8
Total zone transitions, NPP test	0.4	0.6	1.9	-0.9	0.9	-0.3	-0.3	-0.3	0.4	1.4
Total locomotion distance, NPP test	0.3	0.5	1.1	-1.1	1.1	-0.2	-0.2	-0.2	0.4	0.9
Locomotion velocity, NPP test	0.4	0.6	1.5	-1.2	1.2	0.0	0.0	0.0	0.1	0.9
Intraocular pressure	0.3	0.4	1.3	1.1	-1.1	-0.0	0.3	0.2	-0.3	-0.5
Delta distance traveled before/after self-admin	2.2	2.3	2.7	-1.6	1.6	1.6	1.6	1.6	-1.4	-1.3
Delta ambulatory time before/after self-admin	2.3	2.5	2.9	-1.7	1.7	1.6	1.7	1.7	-1.5	-1.2
Parametrial fat weight	0.4	0.8	1.3	-0.5	0.5	1.0	0.8	0.8	-1.1	-1.1
Pavlov. Cond. lever latency	0.3	0.4	1.4	1.2	-1.2	-0.3	-0.3	-0.3	0.1	0.1
Pavlov. Cond. magazine entry latency	4.6	5.9	6.4	-2.4	2.4	2.5	2.5	2.5	-2.4	-2.1
Pavlov. Cond. change in total contacts	0.7	0.7	0.9	-1.0	1.0	0.8	0.8	0.8	-0.6	-1.0
Pavlov. Cond. index score	1.5	1.9	3.2	-1.8	1.8	1.3	1.3	1.3	-1.1	-1.0
Pavlov. Cond. latency score	1.5	2.0	3.9	-2.0	2.0	1.2	1.2	1.2	-1.0	-0.8
Pavlov. Cond. lever contacts	0.6	0.7	2.0	-1.4	1.4	0.5	0.5	0.5	-0.2	-0.0
Pavlov. Cond. magazine entry number	1.6	2.0	2.4	1.6	-1.6	-1.4	-1.4	-1.4	1.3	1.2
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.3	-0.3	0.3	0.3	0.3	-0.4	-0.6
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	3.8	-1.9	1.9	1.5	1.5	1.5	-1.4	-1.2
Pavlov. Cond. response bias	2.3	2.8	3.3	-1.8	1.8	1.7	1.7	1.7	-1.5	-1.5
Pavlov. Cond. lever latency	0.4	0.6	0.7	0.7	-0.7	-0.8	-0.8	-0.8	0.8	0.7
Pavlov. Cond. magazine entry latency	0.6	0.7	0.9	-0.7	0.7	0.9	0.9	0.9	-0.8	-0.8
Pavlov. Cond. change in total contacts	0.3	0.4	0.5	-0.4	0.4	0.7	0.7	0.7	-0.7	-0.5
Pavlov. Cond. index score	0.6	0.8	1.0	-0.7	0.7	1.0	1.0	1.0	-0.9	-0.9
Pavlov. Cond. latency score	0.5	0.6	0.7	-0.7	0.7	0.8	0.9	0.9	-0.8	-0.7
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-0.5	0.5	0.9	0.9	0.9	-0.9	-1.0
Pavlov. Cond. magazine entry number	0.9	1.1	1.2	1.0	-1.0	-1.1	-1.1	-1.1	1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.0	1.0	-1.0	-0.4	-0.5	-0.5	0.5	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.0	-0.8	0.8	1.0	1.0	1.0	-0.9	-0.8
Pavlov. Cond. response bias	1.3	1.8	2.3	-0.9	0.9	1.5	1.5	1.5	-1.5	-1.4
Time in closed arm before self-admin	1.0	1.1	1.9	0.1	-0.1	-0.9	-1.4	-1.3	1.1	1.4
Time in closed arm after self-admin	0.1	0.1	0.1	0.0	-0.0	0.2	-0.4	-0.3	-0.2	-0.3
Time in open arm before self-admin	1.1	1.2	2.2	-0.7	0.7	1.0	1.5	1.5	-0.9	-1.0
Time in open arm after self-admin	0.8	0.9	1.3	1.1	-1.1	-1.2	-0.7	-0.7	0.9	0.9
Bone: periosteal estimation	0.2	0.4	0.6	0.2	-0.2	-0.7	-0.7	-0.7	0.8	0.7
Bone: periosteal perimeter	0.1	0.2	0.6	-0.8	0.8	0.2	0.2	0.2	-0.1	0.3
Bone: post-yield work	0.2	0.3	0.5	0.7	-0.7	-0.3	-0.2	-0.2	0.6	-0.7
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	0.5	-0.5	0.2	0.5	0.4	0.0	-0.8
Progressive ratio test 1 breakpoint	0.2	0.2	0.6	0.6	-0.6	0.2	0.4	0.4	0.1	-0.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.2	-0.1	0.1	0.3	0.4	0.4	-0.2	-0.3
Progressive ratio test 2 active lever presses	0.2	0.2	0.7	0.0	-0.0	0.5	0.3	0.4	-0.5	-0.8
Progressive ratio test 2 breakpoint	0.2	0.2	0.4	-0.3	0.3	0.5	0.3	0.3	-0.5	-0.6
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.4	0.4	0.1	0.1	0.1	-0.1	0.1
Incentive Sensitization - Responses	0.1	0.1	0.2	0.1	-0.1	0.2	-0.2	-0.1	-0.4	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.0	0.0	0.3	-0.1	-0.1	-0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.1	0.1	-0.2	0.0	0.0	0.0	0.3
Progressive ratio	0.1	0.1	0.1	0.2	-0.2	-0.1	-0.3	-0.3	0.1	-0.3
Food seeking constrained by brief footshock	0.6	0.7	1.2	-1.1	1.1	0.8	0.9	0.9	-0.6	-0.3
Seeking ratio, punishment vs. effort	0.3	0.4	0.6	-0.8	0.8	0.4	0.7	0.7	-0.3	0.2
Retroperitoneal fat weight	0.2	0.6	0.9	0.9	-0.9	-0.6	-1.0	-0.9	0.5	0.0
Reaction time number correct	0.8	1.1	3.0	1.7	-1.7	-0.3	-0.5	-0.5	0.5	-1.0
Reaction time mean minus median	0.6	0.8	1.1	-0.6	0.6	1.0	0.9	0.9	-0.9	-1.0
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.4	0.4	0.1	0.0	0.0	0.1	0.2
Reaction time num false alarms	0.2	0.3	0.8	0.7	-0.7	-0.1	0.2	0.2	0.2	-0.9
Reaction time num false alarms AUC	0.3	0.4	1.1	0.9	-0.9	-0.1	0.1	0.1	0.2	-1.1
Reaction time trials correct on left	0.8	1.1	3.0	1.7	-1.7	-0.3	-0.5	-0.5	0.5	-1.0
Reaction time trials on left	0.8	1.1	3.0	1.7	-1.7	-0.4	-0.5	-0.5	0.5	-0.9
Reaction time mean	0.1	0.1	0.2	0.2	-0.2	-0.2	-0.4	-0.4	0.3	0.4
Reaction time mean AUC	0.1	0.2	0.4	0.2	-0.2	-0.4	-0.6	-0.5	0.4	0.6
Median of all reaction times	0.4	0.6	0.9	0.5	-0.5	-0.8	-0.9	-0.9	0.8	0.9
Reaction time omissions	0.1	0.1	0.4	-0.3	0.3	0.2	0.1	0.1	-0.3	0.6
Reaction time false alarm rate	0.0	0.0	0.0	-0.1	0.1	-0.1	0.2	0.1	0.1	-0.2
Reaction time premature initiation rate	0.7	0.9	1.4	-0.5	0.5	1.0	1.2	1.2	-1.2	-0.7
Reaction time premature initiations	0.6	0.9	1.7	0.4	-0.4	0.9	1.0	1.0	-1.0	-1.3
Std. dev. reaction times	0.1	0.1	0.2	-0.3	0.3	0.5	0.3	0.3	-0.4	-0.4
Reaction time trials completed	0.8	1.1	3.0	1.7	-1.7	-0.4	-0.5	-0.5	0.5	-0.9
Reaction time trials AUC	0.8	1.2	3.3	1.8	-1.8	-0.3	-0.4	-0.4	0.4	-1.1
Run reversals in cocaine runway, females	0.5	0.4	0.6	-0.7	0.7	0.8	0.5	0.6	-0.7	-0.6
Run reversals in cocaine runway, males	1.2	1.2	1.9	-1.4	1.4	1.1	0.9	0.9	-1.2	-0.3
Latency to leave start box in cocaine runway	0.5	0.6	1.4	-1.2	1.2	0.1	-0.2	-0.2	-0.1	1.0
Latency to leave start box in cocaine runway, F	1.3	1.4	4.8	-0.4	0.4	-1.1	-1.2	-1.1	1.0	2.2
Latency to leave start box in cocaine runway, M	2.8	2.7	4.5	-1.1	1.1	2.0	1.5	1.5	-1.8	-2.1
Std. dev. time between licks in bursts	0.6	0.7	1.0	-1.0	1.0	0.9	0.8	0.8	-0.6	-0.5
Total sessions with >9 infusions	0.0	0.0	0.1	0.0	-0.0	-0.2	-0.1	-0.1	0.3	0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.4	0.4	0.4	0.4	0.4	-0.3	-0.3
Short access day 10 total inactive lever presses	0.0	0.0	0.0	0.2	-0.2	-0.0	-0.1	-0.1	0.0	-0.1
Short access day 1 total infusions	0.3	0.3	0.8	-0.9	0.9	0.4	0.3	0.3	-0.2	0.1
Short access day 10 total infusions	0.3	0.4	0.8	0.1	-0.1	0.5	0.9	0.9	-0.4	-0.9
Short access total infusions	0.0	0.0	0.0	-0.1	0.1	0.0	0.2	0.1	0.1	-0.0
Short access day 1 locomotion	0.8	0.9	1.4	-1.2	1.2	1.0	0.8	0.8	-0.9	-0.4
Short access day 10 total locomotion	3.5	3.9	4.6	-1.8	1.8	2.1	2.1	2.1	-2.1	-1.8
Short access total locomotion	0.9	0.9	1.2	-1.0	1.0	0.9	1.1	1.1	-0.8	-0.7
One hour access (0.3 mA shock)	0.0	0.1	0.1	0.3	-0.3	-0.3	0.1	0.0	0.3	-0.1
Compulsive drug intake	1.5	1.5	2.5	0.8	-0.8	-1.5	-1.2	-1.2	1.4	1.6
One hour access (shock baseline)	0.4	0.5	1.3	0.0	-0.0	0.6	0.8	0.8	-0.6	-1.2
Social response proportion	0.5	0.6	1.3	-1.2	1.2	0.6	0.5	0.6	-0.5	0.3
Social responses	6.0	7.7	10.6	-3.3	3.3	2.8	2.8	2.8	-2.7	-1.5
Social time	0.7	0.9	1.2	0.7	-0.7	-1.0	-1.1	-1.1	1.1	1.0
Soleus weight	8.2	23.9	27.1	5.2	-5.2	-5.1	-5.1	-5.1	5.0	3.0
Bone: stiffness	1.8	2.9	4.7	1.6	-1.6	-1.8	-1.8	-1.8	2.2	0.9
Tibialis anterior weight	0.7	2.5	3.4	1.8	-1.8	-1.6	-1.6	-1.6	1.8	0.5
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.2	-1.1	1.1	0.4	0.9	0.9	-0.4	0.4
Time to tail flick, vehicle, after self-admin	0.3	0.3	1.4	0.1	-0.1	0.6	0.2	0.3	-0.7	-1.2
Time to tail flick, test, before self-admin	0.3	0.3	0.6	-0.8	0.8	0.2	0.5	0.5	-0.2	0.5
Time to tail flick, test, after self-admin	0.3	0.3	0.6	-0.8	0.8	0.7	0.1	0.2	-0.5	-0.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.3	1.1	-1.1	-0.1	-0.9	-0.8	0.2	-1.0
Delta time to tail flick, test, before/after SA	0.3	0.3	1.1	-0.1	0.1	0.7	-0.0	0.1	-0.6	-1.1
Tibia length	0.8	2.4	2.9	-1.3	1.3	1.6	1.7	1.7	-1.7	-1.4
Ambulatory time before self-admin	0.9	1.0	1.9	0.6	-0.6	-0.9	-1.4	-1.3	0.8	1.0
Ambulatory time after self-admin	0.2	0.2	0.3	-0.6	0.6	0.5	0.1	0.1	-0.5	-0.1
Bone: tissue strength	1.9	1.8	2.3	1.1	-1.1	-1.5	-1.5	-1.5	1.5	1.3
Total heroin consumption	1.8	2.1	2.5	-1.5	1.5	1.4	1.6	1.6	-1.5	-0.8
Bone: trabecular number	0.7	1.1	2.9	-1.7	1.7	0.6	0.6	0.6	-0.7	0.6
Bone: trabecular spacing	1.0	1.4	3.6	1.9	-1.9	-0.1	-0.1	-0.1	0.2	-1.5
Bone: trabecular thickness	1.8	2.2	8.2	-1.2	1.2	-1.1	-1.1	-1.1	0.9	2.9
Bone: trabecular tissue density	1.1	1.5	2.4	1.6	-1.6	-1.1	-1.1	-1.1	1.3	0.2
Water consumed over 24 hours	0.6	0.7	1.0	0.7	-0.7	-0.9	-0.9	-0.9	1.0	0.7
Number of responses in last shaping day	0.1	0.1	0.2	-0.4	0.4	0.3	0.3	0.3	-0.4	-0.4