Hub : Genes

C2cd3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression C2cd3 0.21 0.13 3.2e-06 0.06 0.13 0.14 0.12 9.8e-04 3.6e-06 1.6e-06 5.5e-06
2 BLA intron excision ratio chr1_154721739_154732359 0.06 0.05 7.5e-03 0.03 0.03 0.01 0.02 1.3e-02 1.3e-02 6.9e-02 2.6e-02
3 PL mRNA stability C2cd3 0.02 0.02 9.3e-03 0.02 0.01 0 0.01 5.4e-03 1.9e-02 9.0e-02 9.9e-03
4 Adipose gene expression C2cd3 0.03 0.03 2.4e-03 0.02 0.01 0 0.01 5.0e-03 2.2e-02 2.2e-01 1.9e-02
5 Adipose mRNA stability C2cd3 0.06 0.05 2.5e-06 0.04 0.04 0.03 0.04 2.7e-05 4.1e-05 2.5e-04 6.2e-05
6 BLA gene expression C2cd3 0.11 0.08 1.1e-04 0.05 0.07 0.05 0.06 9.7e-04 7.8e-05 9.7e-04 4.5e-04
7 PL gene expression C2cd3 0.11 0.06 1.0e-11 0.11 0.12 0.11 0.11 1.1e-11 1.1e-12 2.9e-12 2.9e-12
8 NAcc gene expression C2cd3 0.1 0.06 6.0e-12 0.09 0.1 0.1 0.1 1.9e-10 5.2e-12 1.3e-11 2.3e-11
9 Brain gene expression C2cd3 0.28 0.14 0.0e+00 0.21 0.25 0.24 0.25 3.7e-19 5.2e-23 1.6e-22 5.6e-23
10 Brain mRNA stability C2cd3 0.13 0.08 2.7e-09 0.05 0.1 0.1 0.1 3.4e-05 6.4e-10 2.3e-09 9.6e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.10.20.40.10.40.40.30.3-0.4-0.5-0.5-0.5-0.6
Area under the delay curve0.20.20.5-0.7-0.4-0.4-0.5-0.50.50.50.50.50.4
BMI with tail0.10.30.4-0.6-0.5-0.5-0.4-0.50.60.60.60.60.6
BMI without tail1.22.55.1-0.2-1.3-1.3-1.2-1.21.61.81.82.02.3
Body weight1.04.27.7-0.8-1.7-1.7-1.8-1.82.12.32.32.52.8
Weight adjusted by age0.30.30.80.3-0.4-0.4-0.4-0.40.50.60.60.70.9
Bone surface0.40.61.31.20.90.90.90.9-0.7-0.6-0.6-0.5-0.3
Bone volume0.30.40.80.90.80.80.70.7-0.6-0.6-0.6-0.5-0.3
Breakpoint value in progressive ratio session0.10.10.4-0.30.20.20.20.2-0.3-0.4-0.5-0.5-0.7
Number of licking bursts4.95.88.6-2.9-2.5-2.5-2.6-2.62.42.22.22.11.7
Context. condit. distance diff. score2.93.54.12.02.02.02.02.0-1.9-1.8-1.8-1.7-1.5
Locomotion velocity, session 10.30.30.8-0.00.40.40.40.4-0.6-0.7-0.7-0.8-0.9
Locomotion distance, session 11.31.71.81.31.41.41.31.3-1.3-1.3-1.3-1.2-1.1
Locomotion velocity, session 20.00.00.00.20.10.10.10.1-0.1-0.0-0.0-0.00.0
Locomotion distance, session 20.50.70.90.90.90.90.90.9-0.8-0.8-0.8-0.7-0.6
Locomotion velocity, session 31.51.71.91.01.41.41.31.3-1.3-1.4-1.3-1.3-1.3
Locomotion distance, session 32.72.93.21.51.81.81.71.7-1.7-1.7-1.7-1.7-1.6
Stereotopy head waving bouts, day 30.91.01.1-0.9-1.0-1.0-1.0-1.01.01.01.01.01.0
Stereotopy head waving duration, day 30.20.20.20.30.40.40.50.5-0.5-0.5-0.5-0.5-0.5
Locomotion velocity, session 70.00.00.1-0.4-0.1-0.1-0.1-0.1-0.0-0.1-0.1-0.2-0.3
Locomotion distance, session 70.10.20.2-0.5-0.4-0.4-0.4-0.40.40.40.40.40.3
Stereotopy head waving bouts, day 72.73.13.71.91.91.91.91.9-1.8-1.7-1.7-1.6-1.3
Stereotopy head waving duration, day 72.42.94.02.01.91.91.91.9-1.7-1.6-1.5-1.4-1.1
Locomotion velocity, session 80.70.81.00.91.01.01.01.0-0.9-0.9-0.9-0.8-0.7
Locomotion distance, session 82.13.14.42.11.91.91.91.9-1.8-1.7-1.6-1.5-1.2
Degree of sensitization distance3.73.74.4-1.4-1.9-1.9-1.9-1.92.02.12.12.12.1
Degree of sensitization stereotypy5.56.17.92.82.72.72.72.7-2.5-2.3-2.3-2.1-1.7
Conditioned locomotion0.10.10.20.10.20.20.20.2-0.3-0.4-0.4-0.4-0.5
Cocaine response after cond. corrected2.73.03.5-1.8-1.9-1.9-1.8-1.81.81.71.71.61.4
Cocaine response after cond. not corrected0.60.71.0-1.0-0.9-0.9-0.8-0.80.80.80.80.70.6
Cocaine response before conditioning3.13.84.21.72.12.12.12.1-2.0-2.0-1.9-1.9-1.7
Saline control response0.30.41.81.30.70.70.70.7-0.5-0.3-0.3-0.10.3
Bone: connectivity density0.50.71.00.60.90.90.70.7-0.9-0.9-0.9-1.0-1.0
Bone: cortical apparent density2.53.33.7-1.9-1.9-1.9-1.9-1.91.91.81.81.71.5
Bone: cortical area0.00.10.20.4-0.0-0.00.00.00.10.20.20.30.5
Bone: cortical porosity1.92.12.21.21.41.41.51.5-1.5-1.5-1.5-1.4-1.3
Bone: cortical porosity1.71.92.01.11.41.41.41.4-1.4-1.4-1.4-1.4-1.3
Bone: cortical thickness0.00.10.2-0.4-0.3-0.3-0.3-0.30.20.10.10.1-0.0
Bone: cortical thickness0.30.40.40.50.60.60.60.6-0.6-0.6-0.6-0.6-0.6
Bone: cortical tissue density2.33.13.5-1.8-1.9-1.9-1.8-1.81.81.71.71.61.4
Condit. Reinf. active minus inactive responses0.20.20.50.0-0.3-0.3-0.3-0.30.40.50.50.60.7
Condit. Reinf. active-inactive response ratio0.20.20.60.3-0.2-0.2-0.2-0.20.30.50.50.60.8
Condit. Reinf. active responses0.10.10.3-0.2-0.3-0.3-0.3-0.30.40.40.40.50.5
Condit. Reinf. inactive responses0.00.00.0-0.10.00.00.00.0-0.0-0.1-0.1-0.1-0.2
Incentive salience index mean0.10.10.30.1-0.1-0.1-0.1-0.10.30.30.40.40.6
Condit. Reinf. lever presses0.00.00.00.10.10.10.10.1-0.00.00.00.10.1
Condit. Reinf. active minus inactive responses1.62.07.72.81.61.61.61.6-1.1-0.8-0.7-0.40.2
Condit. Reinf. active-inactive response ratio0.70.82.21.51.01.01.01.0-0.8-0.6-0.6-0.5-0.2
Condit. Reinf. active responses1.62.29.73.11.61.61.61.6-1.0-0.6-0.6-0.20.6
Condit. Reinf. inactive responses0.60.83.81.90.90.90.90.9-0.5-0.2-0.10.10.7
Condit. Reinf. lever presses6.69.024.75.03.43.43.33.3-2.7-2.2-2.1-1.7-0.7
Condit. Reinf. lever reinforcers received2.23.111.93.51.91.91.91.9-1.4-0.9-0.9-0.50.3
Conditioned reinforcement - actives3.43.44.11.81.91.92.02.0-1.9-1.8-1.8-1.7-1.5
Conditioned reinforcement - inactives0.30.30.4-0.5-0.6-0.6-0.5-0.50.50.60.60.60.6
Conditioned locomotion4.55.57.02.02.62.62.42.4-2.3-2.3-2.3-2.2-2.0
Patch foraging indifference point 0 sec2.33.76.32.52.12.12.22.2-1.9-1.7-1.7-1.5-1.0
Patch foraging indifference point AUC0.70.91.4-0.3-0.9-0.9-0.8-0.81.01.01.01.11.2
Delay disc. indifference point, 0s delay0.10.20.50.70.50.50.50.5-0.3-0.2-0.2-0.10.0
Delay disc. indifference point, 16s delay0.00.00.1-0.40.00.00.00.0-0.0-0.1-0.1-0.1-0.2
Delay disc. indifference point, 2s delay0.10.10.60.1-0.1-0.1-0.1-0.10.30.40.40.50.8
Delay disc. indifference point, 24s delay0.40.41.3-1.1-0.7-0.7-0.7-0.70.60.50.40.40.1
Delay disc. indifference point, 4s delay0.30.31.00.2-0.3-0.3-0.3-0.30.60.70.70.81.0
Delay disc. indifference point, 8s delay0.00.00.2-0.4-0.0-0.0-0.1-0.10.10.10.00.10.1
Indifference point function ln k3.04.24.61.62.12.12.12.1-2.1-2.2-2.1-2.1-2.0
Indifference point function log k3.04.24.61.62.12.12.12.1-2.1-2.2-2.1-2.1-2.0
Patch foraging total patch changes 0 sec1.72.74.82.21.81.81.91.9-1.6-1.4-1.4-1.2-0.8
Patch foraging total patch changes 12 sec0.20.30.80.9-0.1-0.10.00.00.30.40.50.60.9
Patch foraging total patch changes 18 sec0.50.72.01.40.90.91.01.0-0.7-0.5-0.5-0.30.0
Patch foraging total patch changes 24 sec0.20.20.70.8-0.1-0.10.10.10.20.40.40.50.8
Patch foraging total patch changes 6 sec0.40.51.01.00.70.70.80.8-0.7-0.7-0.6-0.6-0.4
Patch foraging time to switch 0 sec1.32.05.4-2.3-1.6-1.6-1.6-1.61.31.11.00.80.3
Patch foraging water rate 0 sec1.93.15.92.41.91.92.02.0-1.7-1.6-1.5-1.4-0.9
Patch foraging water rate 12 sec2.23.35.12.31.91.92.02.0-1.9-1.7-1.7-1.6-1.3
Patch foraging water rate 18 sec0.50.62.61.60.90.90.80.8-0.6-0.5-0.4-0.3-0.0
Patch foraging water rate 24 sec2.43.43.51.91.81.81.91.9-1.9-1.9-1.8-1.8-1.7
Patch foraging water rate 6 sec1.52.12.91.71.51.51.51.5-1.5-1.4-1.4-1.3-1.1
Seeking ratio, delayed vs. immediate footshock0.10.10.6-0.7-0.1-0.1-0.4-0.40.1-0.0-0.1-0.2-0.5
Distance traveled before self-admin1.31.42.3-1.5-1.3-1.3-1.3-1.31.21.01.00.90.7
Distance traveled after self-admin0.60.71.5-0.00.80.80.70.7-0.8-0.9-0.9-1.0-1.2
Extensor digitorum longus weight0.62.43.1-1.2-1.4-1.4-1.5-1.51.61.71.71.71.8
Bone: elastic displacement0.40.41.6-1.3-0.8-0.8-0.6-0.60.40.20.20.0-0.3
Bone: elastic work0.20.31.3-1.2-0.6-0.6-0.4-0.40.1-0.1-0.1-0.3-0.7
Bone: endosteal estimation0.10.31.20.90.10.10.10.10.20.50.50.71.1
Bone: endosteal perimeter0.20.31.61.20.50.50.40.4-0.10.20.20.40.8
Epididymis fat weight2.25.05.4-2.1-2.2-2.2-2.2-2.12.32.32.32.32.3
Delta time in closed arm before/after self-admin6.56.36.8-1.9-2.6-2.6-2.5-2.52.62.62.62.62.5
Delta time in open arm before/after self-admin2.12.14.02.01.61.61.61.6-1.4-1.2-1.1-1.0-0.6
Diff in mean of infusions in LGA sessions2.83.14.4-1.7-2.1-2.1-2.0-2.01.81.61.61.51.1
Delay discount exponential model param0.30.30.50.70.40.40.50.5-0.5-0.5-0.5-0.5-0.5
Extinction: sum of active levers before priming0.10.10.2-0.4-0.2-0.2-0.3-0.30.30.30.30.30.2
Active lever presses in extinction session 66.15.96.71.82.62.62.42.4-2.5-2.5-2.5-2.5-2.4
Bone: final force0.00.00.1-0.2-0.3-0.3-0.2-0.20.20.20.20.20.2
Bone: final moment0.00.00.0-0.0-0.1-0.1-0.0-0.00.10.10.10.10.2
Food consumed during 24 hour testing period3.94.76.32.52.42.42.32.3-2.2-2.0-2.0-1.9-1.5
Glucose0.10.20.20.20.40.40.40.4-0.4-0.4-0.4-0.4-0.4
Heart weight0.81.21.81.11.31.31.21.2-1.1-1.0-1.0-0.9-0.6
Delay discount hyperbolic model param0.30.30.40.60.40.40.50.5-0.6-0.6-0.6-0.6-0.6
Intermittent access intake day 1-15 change0.60.61.21.10.90.90.70.7-0.7-0.7-0.6-0.6-0.5
Intermittent access intake escalation0.70.71.41.21.01.00.80.8-0.8-0.8-0.7-0.7-0.6
Intermittent access intake escalation 20.10.10.20.5-0.0-0.0-0.2-0.20.20.20.30.30.4
Intermitt. access day 1 inactive lever presses0.50.60.7-0.6-0.7-0.7-0.8-0.80.80.80.80.80.7
Intermitt. access day 15 inactive lever presses0.40.50.60.30.60.60.80.8-0.8-0.7-0.8-0.7-0.7
Intermitt. access escalation Index0.30.20.50.60.70.70.40.4-0.4-0.4-0.4-0.3-0.2
Intermittent access day 1 total infusions0.60.71.21.10.90.91.11.1-0.8-0.7-0.7-0.6-0.3
Intermittent access day 15 total infusions1.51.72.51.61.51.51.41.4-1.3-1.2-1.2-1.1-0.8
Intermittent access terminal intake (last 3 days)0.91.01.61.31.21.21.11.1-1.0-0.9-0.8-0.7-0.5
Intermittent access total infusions0.60.71.51.20.90.91.01.0-0.8-0.7-0.7-0.6-0.3
Intermittent access day 1 locomotion0.40.40.60.20.70.70.70.7-0.7-0.6-0.7-0.6-0.6
Intermittent access day 15 total locomotion1.51.62.11.31.51.51.41.4-1.3-1.2-1.2-1.1-0.9
Intermittent access total locomotion0.60.71.00.80.90.91.01.0-0.8-0.7-0.8-0.7-0.5
Intermittent access standard deviation0.10.10.1-0.2-0.3-0.3-0.2-0.20.20.30.30.30.4
Left kidney weight0.41.03.10.0-0.7-0.7-0.6-0.61.01.21.21.41.8
Right kidney weight0.30.92.3-0.1-0.6-0.6-0.7-0.70.91.01.11.21.5
Cocaine induced anxiety1.31.53.8-2.0-1.4-1.4-1.3-1.31.10.90.90.80.5
Post-drug Anxiety1.31.41.6-1.1-1.3-1.3-1.3-1.31.21.11.11.10.9
Baseline Anxiety0.40.42.21.50.70.70.50.5-0.4-0.2-0.2-0.10.1
Tail length1.64.712.40.7-1.5-1.5-1.5-1.52.12.52.62.93.5
Length with tail1.45.110.8-0.1-1.8-1.8-1.8-1.82.22.62.62.83.3
Length without tail0.10.20.5-0.7-0.5-0.5-0.5-0.50.30.30.30.20.1
Times rat made contact with spout1.21.41.6-1.0-1.1-1.1-1.2-1.21.21.31.31.31.3
Lifetime Intake0.91.02.31.51.01.01.21.2-1.0-0.8-0.8-0.7-0.5
Liver weight, left2.33.64.1-1.5-1.9-1.9-1.9-1.92.02.02.02.02.0
Liver weight, right5.08.49.4-2.2-2.9-2.9-2.8-2.83.03.03.13.13.0
Locomotor activity0.40.60.80.70.90.90.90.9-0.8-0.8-0.8-0.7-0.6
Locomotor testing distance0.50.91.91.41.11.11.11.1-0.9-0.7-0.7-0.6-0.2
Locomotor testing rearing0.20.31.00.2-0.3-0.3-0.3-0.30.50.60.60.81.0
Locomotion in novel chamber1.82.22.81.01.71.71.41.4-1.5-1.6-1.5-1.6-1.5
Locomotion in novel chamber post-restriction2.93.54.41.92.02.02.12.1-1.9-1.8-1.8-1.7-1.5
Fecal boli incidents, locomotor time 11.71.92.21.11.51.51.41.4-1.4-1.4-1.4-1.4-1.3
Change in fecal boli incidents, locomotor task1.00.91.2-0.8-1.1-1.1-1.1-1.11.00.90.90.80.7
Time >=10cm from walls, locomotor time 12.42.43.11.51.81.81.71.7-1.6-1.5-1.5-1.4-1.2
Bouts of movement, locomotor time 10.30.30.50.60.70.70.60.6-0.6-0.5-0.5-0.5-0.5
Total resting periods, locomotor time 10.70.80.90.71.01.00.90.9-0.9-0.9-0.9-0.9-1.0
Rest time, locomotor task time 10.30.30.60.20.50.50.50.5-0.6-0.7-0.7-0.7-0.8
Distance moved, locomotor task time 10.70.81.5-0.2-0.7-0.7-0.8-0.80.91.01.01.11.2
Vertical activity count, locomotor time 10.20.20.60.1-0.3-0.3-0.3-0.30.40.50.50.60.8
Time >=10cm from walls, locomotor time 20.60.61.61.30.80.81.01.0-0.8-0.6-0.6-0.5-0.2
Bouts of movement, locomotor time 20.50.51.20.1-0.5-0.5-0.6-0.60.80.80.90.91.1
Total resting periods, locomotor time 20.70.71.2-0.2-0.7-0.7-0.8-0.80.91.01.01.01.1
Rest time, locomotor task time 21.21.42.9-1.7-1.5-1.5-1.3-1.31.00.90.80.70.3
Distance moved, locomotor task time 20.80.92.61.61.21.21.01.0-0.8-0.6-0.6-0.40.1
Vertical activity count, locomotor time 20.10.10.40.70.20.20.20.20.00.20.20.30.6
Light reinforcement 11.62.86.2-2.5-1.9-1.9-1.7-1.81.61.41.31.20.8
Light reinforcement 20.10.10.3-0.50.10.10.10.1-0.2-0.3-0.3-0.4-0.6
Bone: marrow area0.20.31.40.7-0.0-0.0-0.0-0.00.40.60.60.81.2
Bone: maximum diameter0.20.41.61.30.60.60.70.7-0.4-0.2-0.10.00.5
Bone: maximum force0.00.00.00.0-0.1-0.10.00.00.00.00.00.10.1
Bone: maximum moment0.00.00.10.30.10.10.20.2-0.1-0.1-0.1-0.00.1
Mean time between licks in bursts0.40.62.21.50.30.30.40.40.20.50.60.91.5
Mean num. licks in bursts3.44.16.62.62.12.12.22.2-2.0-1.9-1.8-1.7-1.3
Cd content in liver1.31.51.6-1.0-1.2-1.2-1.1-1.11.31.31.31.31.2
Co content in liver0.10.20.80.90.20.20.30.3-0.00.10.20.30.6
Cu content in liver0.20.20.90.5-0.1-0.1-0.1-0.10.40.50.60.70.9
Fe content in liver0.10.10.1-0.3-0.4-0.4-0.3-0.30.30.30.30.30.3
K content in liver0.70.70.7-0.7-0.8-0.8-0.8-0.80.80.80.80.80.8
Mg content in liver0.00.00.10.20.10.10.10.1-0.1-0.00.00.00.1
Mn content in liver0.20.20.7-0.8-0.1-0.1-0.2-0.2-0.2-0.3-0.4-0.5-0.8
Na content in liver0.30.30.40.60.60.60.60.6-0.6-0.6-0.6-0.5-0.5
Rb content in liver0.20.20.90.90.50.50.50.5-0.4-0.3-0.3-0.20.0
Se content in liver1.21.43.8-1.9-1.4-1.4-1.4-1.41.10.90.80.70.2
Sr content in liver0.40.30.50.40.40.40.50.5-0.6-0.7-0.7-0.7-0.7
Zn content in liver2.22.45.42.31.81.81.71.7-1.5-1.3-1.2-1.0-0.6
Bone: minimum diameter0.81.63.6-0.2-0.9-0.9-1.0-1.01.31.51.51.61.9
Time in familiar zone, hab. session 10.20.20.3-0.2-0.4-0.4-0.4-0.40.50.50.50.50.6
Time in novel zone, hab. session 10.20.20.3-0.6-0.4-0.4-0.5-0.50.40.40.40.30.2
Total zone transitions, hab. session 10.50.71.00.40.70.70.70.7-0.8-0.9-0.9-0.9-1.0
Total locomotion distance, hab. session 12.33.33.7-1.4-1.8-1.8-1.8-1.81.91.91.91.91.9
Locomotion velocity, hab. session 11.31.92.2-1.0-1.4-1.4-1.4-1.41.41.51.51.51.5
Time in familiar zone, hab. session 20.40.41.11.10.70.70.70.7-0.6-0.4-0.4-0.30.0
Time in novel zone, hab. session 20.00.00.1-0.4-0.1-0.1-0.1-0.1-0.0-0.1-0.1-0.2-0.3
Total zone transitions, hab. session 22.12.73.01.61.71.71.71.7-1.7-1.6-1.6-1.6-1.4
Total locomotion distance, hab. session 21.01.42.3-0.5-1.1-1.1-1.0-1.01.21.31.31.41.5
Locomotion velocity, hab. session 21.52.13.1-0.7-1.3-1.3-1.3-1.31.51.61.61.71.8
Novel to familiar place preference ratio0.10.10.10.40.30.30.30.3-0.3-0.3-0.3-0.3-0.2
Novelty place preference0.10.10.10.40.30.30.30.3-0.3-0.3-0.3-0.3-0.2
Time in novel zone, NPP test0.20.20.30.60.50.50.50.5-0.5-0.5-0.5-0.4-0.4
Total zone transitions, NPP test0.60.90.90.81.01.00.90.9-1.0-1.0-1.0-1.0-0.9
Total locomotion distance, NPP test1.62.12.5-1.0-1.4-1.4-1.4-1.41.51.61.61.61.6
Locomotion velocity, NPP test1.92.73.0-1.3-1.7-1.7-1.7-1.71.71.71.71.71.7
Intraocular pressure0.81.11.20.81.11.11.01.0-1.0-1.1-1.1-1.1-1.1
Delta distance traveled before/after self-admin2.83.03.61.81.91.91.91.9-1.8-1.6-1.6-1.6-1.4
Delta ambulatory time before/after self-admin3.74.14.81.92.22.22.12.1-2.1-2.0-1.9-1.9-1.8
Parametrial fat weight2.14.04.8-1.7-2.2-2.2-2.0-2.02.02.02.02.01.9
Pavlov. Cond. lever latency0.40.61.1-1.0-0.9-0.9-0.9-0.90.70.60.60.40.2
Pavlov. Cond. magazine entry latency0.91.23.01.71.31.31.31.3-1.0-0.8-0.8-0.6-0.2
Pavlov. Cond. change in total contacts0.40.41.21.10.80.80.80.8-0.6-0.5-0.4-0.3-0.1
Pavlov. Cond. index score0.81.12.71.61.21.21.21.2-0.9-0.7-0.7-0.5-0.1
Pavlov. Cond. latency score0.91.12.61.61.21.21.21.2-1.0-0.8-0.7-0.6-0.2
Pavlov. Cond. lever contacts0.20.20.70.90.60.60.60.6-0.4-0.2-0.2-0.10.2
Pavlov. Cond. magazine entry number1.51.83.9-2.0-1.5-1.5-1.5-1.51.31.11.00.90.4
Pavlov. Cond. intertrial magazine entries0.30.30.8-0.9-0.7-0.7-0.7-0.70.50.40.40.30.1
Pavlov. Cond. lever-magazine prob. diff.0.70.92.11.51.11.11.11.1-0.9-0.7-0.6-0.5-0.1
Pavlov. Cond. response bias0.20.30.90.90.60.60.60.6-0.4-0.3-0.3-0.20.1
Pavlov. Cond. lever latency7.610.325.5-5.0-3.6-3.6-3.6-3.63.02.52.42.01.1
Pavlov. Cond. magazine entry latency3.23.75.92.42.02.02.12.1-1.9-1.7-1.7-1.6-1.2
Pavlov. Cond. change in total contacts7.19.821.64.63.53.53.53.5-3.0-2.6-2.5-2.2-1.3
Pavlov. Cond. index score6.78.619.54.43.23.23.33.3-2.8-2.4-2.3-2.0-1.1
Pavlov. Cond. latency score6.37.817.74.23.13.13.13.1-2.7-2.3-2.2-1.9-1.1
Pavlov. Cond. lever contacts8.010.926.95.23.73.73.73.7-3.1-2.6-2.5-2.1-1.1
Pavlov. Cond. magazine entry number5.56.711.5-3.4-2.8-2.8-2.8-2.82.62.32.32.11.5
Pavlov. Cond. intertrial magazine entries1.21.52.4-0.7-1.1-1.1-1.1-1.11.31.41.41.41.6
Pavlov. Cond. lever-magazine prob. diff.5.87.417.64.23.03.03.13.1-2.6-2.2-2.1-1.8-0.9
Pavlov. Cond. response bias8.912.127.95.33.83.83.93.9-3.3-2.8-2.7-2.3-1.3
Time in closed arm before self-admin6.27.07.81.92.62.62.72.7-2.8-2.8-2.8-2.8-2.7
Time in closed arm after self-admin0.20.20.5-0.7-0.1-0.10.00.0-0.2-0.4-0.4-0.5-0.7
Time in open arm before self-admin4.85.26.5-2.4-2.5-2.5-2.5-2.52.42.12.12.01.6
Time in open arm after self-admin0.70.71.50.0-0.6-0.6-0.7-0.70.91.01.01.11.2
Bone: periosteal estimation0.10.20.90.90.10.10.20.20.20.40.40.60.9
Bone: periosteal perimeter0.10.21.11.00.40.40.40.4-0.10.00.10.20.6
Bone: post-yield work0.10.10.20.40.50.50.40.4-0.3-0.3-0.3-0.3-0.2
Progressive ratio test 1 active lever presses0.00.00.1-0.3-0.2-0.2-0.1-0.10.10.10.10.10.0
Progressive ratio test 1 breakpoint0.10.10.1-0.3-0.3-0.3-0.2-0.20.20.30.30.30.2
Progressive ratio test 1 inactive lever presses0.10.10.30.50.10.10.60.6-0.4-0.2-0.3-0.2-0.0
Progressive ratio test 2 active lever presses0.10.10.40.60.30.30.50.5-0.3-0.2-0.2-0.10.1
Progressive ratio test 2 breakpoint0.10.10.40.60.30.30.50.5-0.3-0.2-0.2-0.10.2
Progressive ratio test 2 inactive lever presses0.91.11.60.90.90.91.31.3-1.1-1.0-1.1-1.0-0.8
Incentive Sensitization - Responses0.30.31.51.20.60.60.60.6-0.4-0.3-0.2-0.10.3
Incentive Sensitization - Breakpoint0.40.41.41.20.70.70.70.7-0.5-0.4-0.4-0.20.1
Sum of active levers in priming session hrs 5-60.10.10.2-0.30.10.10.10.1-0.2-0.3-0.3-0.4-0.5
Progressive ratio0.20.30.40.10.60.60.50.5-0.5-0.6-0.6-0.6-0.6
Food seeking constrained by brief footshock0.10.10.60.30.00.0-0.1-0.10.30.40.40.50.8
Seeking ratio, punishment vs. effort0.60.71.80.2-0.6-0.6-0.5-0.50.80.91.01.11.3
Retroperitoneal fat weight8.728.531.0-4.4-5.3-5.3-5.4-5.45.55.65.55.55.4
Reaction time number correct1.21.82.71.01.21.21.21.2-1.4-1.5-1.4-1.5-1.6
Reaction time mean minus median0.10.10.40.60.30.30.30.3-0.2-0.1-0.10.00.2
Reaction time mean minus median AUC0.70.91.41.21.01.01.01.0-0.9-0.8-0.8-0.7-0.5
Reaction time num false alarms2.43.35.1-2.3-2.0-2.0-1.8-1.91.81.71.71.61.3
Reaction time num false alarms AUC1.01.43.0-1.7-1.3-1.3-1.2-1.21.21.01.01.00.7
Reaction time trials correct on left1.21.82.71.01.21.21.21.2-1.4-1.5-1.4-1.5-1.6
Reaction time trials on left1.21.82.70.91.21.21.21.2-1.4-1.5-1.4-1.5-1.6
Reaction time mean1.11.61.8-1.3-1.2-1.2-1.3-1.31.31.31.21.21.1
Reaction time mean AUC1.01.31.8-1.4-1.2-1.2-1.2-1.21.21.11.11.00.8
Median of all reaction times1.31.82.7-1.6-1.4-1.4-1.4-1.41.41.31.21.20.9
Reaction time omissions0.60.81.4-1.2-0.9-0.9-0.8-0.80.90.80.80.80.7
Reaction time false alarm rate2.33.24.6-2.1-1.9-1.9-1.8-1.81.81.81.71.71.5
Reaction time premature initiation rate0.60.92.80.2-0.5-0.5-0.6-0.50.81.11.11.31.7
Reaction time premature initiations0.10.10.70.80.40.40.30.3-0.10.00.10.20.5
Std. dev. reaction times0.70.91.8-0.3-0.8-0.8-0.8-0.81.01.11.11.21.4
Reaction time trials completed1.21.82.70.91.21.21.21.2-1.4-1.5-1.4-1.5-1.6
Reaction time trials AUC0.91.32.00.81.01.01.01.0-1.2-1.3-1.2-1.3-1.4
Run reversals in cocaine runway, females5.95.78.0-1.3-2.3-2.3-2.2-2.22.52.62.62.72.8
Run reversals in cocaine runway, males0.00.00.1-0.2-0.2-0.20.00.0-0.1-0.1-0.1-0.1-0.2
Latency to leave start box in cocaine runway3.63.94.8-1.6-2.2-2.2-2.1-2.12.02.02.01.91.6
Latency to leave start box in cocaine runway, F4.55.05.4-1.6-2.3-2.3-2.3-2.32.32.32.32.32.1
Latency to leave start box in cocaine runway, M0.00.00.2-0.1-0.1-0.10.00.0-0.1-0.2-0.2-0.3-0.5
Std. dev. time between licks in bursts0.81.03.00.2-0.5-0.5-0.6-0.61.01.21.21.41.7
Total sessions with >9 infusions2.93.24.92.21.81.82.02.0-1.8-1.6-1.6-1.5-1.2
Short access day 1 total inactive lever presses0.00.00.10.2-0.2-0.20.10.1-0.2-0.1-0.1-0.1-0.2
Short access day 10 total inactive lever presses0.00.00.0-0.1-0.0-0.0-0.1-0.10.0-0.0-0.0-0.1-0.1
Short access day 1 total infusions1.11.23.21.81.11.11.31.3-1.1-0.9-0.8-0.7-0.3
Short access day 10 total infusions0.30.31.11.00.50.50.70.7-0.4-0.3-0.2-0.10.2
Short access total infusions0.40.51.71.30.50.50.90.9-0.7-0.5-0.5-0.3-0.1
Short access day 1 locomotion3.53.74.21.82.02.02.12.1-2.0-1.9-1.9-1.8-1.6
Short access day 10 total locomotion0.00.00.20.10.40.40.10.10.00.00.00.10.2
Short access total locomotion0.20.20.40.20.60.60.40.4-0.4-0.3-0.3-0.3-0.2
One hour access (0.3 mA shock)1.01.13.01.71.11.11.21.2-1.0-0.9-0.8-0.7-0.4
Compulsive drug intake0.40.40.80.00.40.40.50.5-0.6-0.7-0.7-0.8-0.9
One hour access (shock baseline)0.50.62.31.50.90.90.80.8-0.6-0.5-0.4-0.30.0
Social response proportion0.91.01.1-0.7-1.0-1.0-1.0-1.01.01.01.01.01.0
Social responses1.82.42.9-1.0-1.5-1.5-1.5-1.51.51.61.61.71.7
Social time0.60.82.0-1.4-1.1-1.1-1.0-1.00.70.50.50.3-0.1
Soleus weight1.74.97.1-1.3-2.0-2.0-2.1-2.12.32.42.42.52.7
Bone: stiffness0.71.11.2-0.9-1.1-1.1-1.0-1.01.11.11.11.11.1
Tibialis anterior weight0.10.41.0-0.2-0.5-0.5-0.5-0.50.70.70.80.81.0
Time to tail flick, vehicle, before self-admin0.10.10.2-0.10.40.40.20.2-0.2-0.2-0.3-0.3-0.3
Time to tail flick, vehicle, after self-admin3.23.54.42.01.91.92.12.1-1.9-1.8-1.8-1.7-1.4
Time to tail flick, test, before self-admin0.10.10.20.30.20.2-0.1-0.10.20.30.30.30.5
Time to tail flick, test, after self-admin0.70.71.60.3-0.7-0.7-0.6-0.60.81.01.01.11.3
Delta time to tail flick, vehicle, before/after SA1.71.72.41.51.31.31.61.6-1.4-1.2-1.2-1.1-0.9
Delta time to tail flick, test, before/after SA0.40.40.7-0.3-0.9-0.9-0.6-0.60.60.50.60.50.5
Tibia length2.67.28.22.92.82.82.82.8-2.7-2.6-2.6-2.5-2.2
Ambulatory time before self-admin0.80.81.9-1.4-1.0-1.0-1.0-1.00.90.70.70.60.4
Ambulatory time after self-admin1.61.83.10.31.21.21.21.2-1.4-1.5-1.5-1.6-1.7
Bone: tissue strength1.11.12.20.30.80.80.80.8-1.1-1.2-1.2-1.3-1.5
Total heroin consumption0.70.81.00.81.01.00.90.9-0.9-0.9-0.9-0.9-0.8
Bone: trabecular number0.10.10.4-0.6-0.0-0.0-0.2-0.2-0.1-0.2-0.2-0.4-0.6
Bone: trabecular spacing0.60.71.41.20.80.81.01.0-0.9-0.8-0.8-0.7-0.5
Bone: trabecular thickness0.30.40.5-0.7-0.7-0.7-0.6-0.60.60.60.60.50.5
Bone: trabecular tissue density3.85.45.7-2.0-2.4-2.4-2.3-2.32.42.42.42.42.3
Water consumed over 24 hours0.10.10.5-0.7-0.3-0.3-0.4-0.40.30.20.10.1-0.1
Number of responses in last shaping day0.10.10.3-0.1-0.2-0.2-0.1-0.10.30.30.30.40.5