Hub : Genes

Btnl3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	gene expression	Btnl3	0.23	0.11	9.3e-04	0.09	0.03	0.09	0.12	3.2e-03	7.6e-02	4.1e-03	8.4e-04
2	Brain	gene expression	Btnl3	0.28	0.1	0.0e+00	0.24	0.24	0.24	0.26	3.5e-22	3.3e-22	5.7e-22	8.7e-24
3	pVTA	gene expression	Btnl3	0.59	0.1	0.0e+00	0.49	0.49	0.52	0.52	2.8e-44	7.0e-45	5.9e-48	4.9e-48
4	IL	gene expression	Btnl3	0.63	0.13	1.1e-08	0.2	0.15	0.22	0.16	1.8e-05	2.0e-04	5.6e-06	1.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.4	0.7	1.7	1.3	0.9	0.4	-0.0
Area under the delay curve	0.0	0.1	0.1	0.3	-0.0	0.2	-0.4
BMI with tail	2.3	7.9	10.7	-3.2	-2.7	-3.3	1.9
BMI without tail	1.5	7.7	8.7	-2.9	-2.9	-2.8	2.5
Body weight	2.9	12.7	16.2	-4.0	-3.9	-3.9	2.0
Weight adjusted by age	0.4	1.2	2.0	-1.3	-1.4	-1.1	-0.0
Bone surface	0.1	0.3	0.8	0.4	0.3	0.1	-0.9
Bone volume	0.0	0.0	0.1	0.3	0.1	-0.2	-0.1
Breakpoint value in progressive ratio session	0.1	0.3	0.3	0.4	0.6	0.5	-0.5
Number of licking bursts	0.3	1.0	1.8	0.3	1.3	1.1	-1.0
Context. condit. distance diff. score	5.3	6.5	8.0	2.6	2.8	2.3	-2.3
Locomotion velocity, session 1	3.1	3.5	4.0	2.0	1.7	1.9	-1.9
Locomotion distance, session 1	0.6	0.8	1.5	1.2	1.0	0.8	-0.1
Locomotion velocity, session 2	0.8	0.9	1.1	1.0	1.0	1.0	-0.8
Locomotion distance, session 2	0.7	0.9	1.4	1.0	1.2	0.8	-0.9
Locomotion velocity, session 3	0.3	0.4	1.4	-0.2	-0.2	-0.1	1.2
Locomotion distance, session 3	1.2	1.4	2.5	1.6	1.3	1.2	-0.0
Stereotopy head waving bouts, day 3	0.3	0.4	0.9	-1.0	-0.4	-0.2	-0.5
Stereotopy head waving duration, day 3	0.3	0.4	1.2	-1.1	-0.5	-0.1	-0.3
Locomotion velocity, session 7	2.8	3.1	4.9	2.2	2.0	1.4	-1.3
Locomotion distance, session 7	3.9	4.9	8.2	2.9	2.4	2.1	-1.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	-0.3	0.1	0.7	0.4
Stereotopy head waving duration, day 7	0.3	0.3	0.8	-0.9	-0.4	0.1	0.6
Locomotion velocity, session 8	3.8	4.5	7.5	1.6	2.0	2.0	-2.7
Locomotion distance, session 8	4.4	6.4	8.6	2.7	2.9	2.1	-2.4
Degree of sensitization distance	0.6	0.7	1.7	0.5	0.6	0.5	-1.3
Degree of sensitization stereotypy	0.3	0.4	1.0	0.3	0.5	1.0	0.3
Conditioned locomotion	0.6	0.8	1.3	-1.1	-0.8	-1.0	-0.3
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	0.3	-0.5	-0.3
Cocaine response after cond. not corrected	0.2	0.3	0.8	-0.9	-0.2	-0.4	-0.4
Cocaine response before conditioning	0.8	0.9	2.0	-1.2	-1.4	-0.4	0.2
Saline control response	4.2	5.8	8.0	-2.3	-2.8	-2.2	2.3
Bone: connectivity density	0.3	0.5	1.1	1.0	0.7	0.2	-0.6
Bone: cortical apparent density	1.6	2.6	3.7	-1.6	-1.8	-1.9	0.9
Bone: cortical area	0.1	0.1	0.3	0.0	-0.6	-0.4	0.1
Bone: cortical porosity	1.2	1.3	2.5	1.3	0.9	1.6	-0.1
Bone: cortical porosity	1.6	1.8	3.2	1.5	1.2	1.8	-0.6
Bone: cortical thickness	1.1	1.8	2.4	-0.6	-1.5	-1.4	1.6
Bone: cortical thickness	2.3	2.8	3.7	-1.6	-1.9	-1.9	1.2
Bone: cortical tissue density	1.5	2.4	3.4	-1.6	-1.7	-1.8	0.7
Condit. Reinf. active minus inactive responses	1.3	1.5	2.3	1.5	1.1	1.4	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.1	-0.3	-0.1	0.6
Condit. Reinf. active responses	0.9	1.1	2.4	1.5	0.9	1.0	-0.5
Condit. Reinf. inactive responses	0.6	0.7	2.1	1.5	0.8	0.5	0.0
Incentive salience index mean	2.9	3.7	4.7	2.2	1.9	1.9	-1.8
Condit. Reinf. lever presses	3.2	4.8	5.7	2.3	2.3	1.8	-2.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.1	-0.6	-0.2	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.2	-0.0	-0.4	-0.0	-0.3
Condit. Reinf. active responses	0.0	0.1	0.1	0.1	-0.3	-0.0	0.4
Condit. Reinf. inactive responses	0.2	0.3	0.6	-0.5	-0.5	-0.5	0.8
Condit. Reinf. lever presses	0.6	0.8	1.8	1.3	0.7	0.9	0.1
Condit. Reinf. lever reinforcers received	0.0	0.1	0.1	0.4	-0.1	0.3	0.2
Conditioned reinforcement - actives	0.0	0.0	0.1	0.4	0.0	-0.2	0.1
Conditioned reinforcement - inactives	0.0	0.0	0.0	-0.2	0.1	0.0	-0.0
Conditioned locomotion	0.2	0.3	0.6	0.8	0.3	0.3	-0.6
Patch foraging indifference point 0 sec	0.9	2.7	3.7	-1.6	-1.9	-1.7	1.2
Patch foraging indifference point AUC	0.0	0.0	0.1	0.1	-0.1	0.3	-0.3
Delay disc. indifference point, 0s delay	0.6	0.6	1.2	0.6	0.8	0.6	-1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.0	-0.4	-0.2	0.3
Delay disc. indifference point, 2s delay	0.6	0.6	1.3	0.5	0.5	0.8	-1.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.0	-0.4	0.1	0.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.7	-0.6	-0.3	-0.1
Delay disc. indifference point, 8s delay	0.2	0.3	0.6	0.8	0.2	0.4	-0.5
Indifference point function ln k	0.3	0.8	1.1	0.6	0.8	1.0	-1.0
Indifference point function log k	0.3	0.8	1.1	0.6	0.8	1.0	-1.0
Patch foraging total patch changes 0 sec	1.0	2.9	4.0	-1.7	-2.0	-1.8	1.3
Patch foraging total patch changes 12 sec	1.4	1.8	2.8	-1.4	-1.7	-1.4	0.8
Patch foraging total patch changes 18 sec	1.4	3.3	4.3	-1.7	-1.8	-2.1	1.7
Patch foraging total patch changes 24 sec	0.2	0.5	1.3	-0.0	-0.6	-0.7	1.1
Patch foraging total patch changes 6 sec	1.3	2.2	2.9	-1.4	-1.7	-1.4	1.3
Patch foraging time to switch 0 sec	0.5	2.1	3.3	-1.4	-1.2	-1.8	1.3
Patch foraging water rate 0 sec	0.1	0.2	0.5	-0.7	-0.5	-0.3	-0.1
Patch foraging water rate 12 sec	0.0	0.1	0.5	-0.2	-0.0	-0.2	0.7
Patch foraging water rate 18 sec	0.2	0.5	0.8	-0.9	-0.6	-0.6	0.7
Patch foraging water rate 24 sec	0.4	0.6	1.0	-0.7	-0.6	-0.7	1.0
Patch foraging water rate 6 sec	0.3	0.5	0.9	-0.7	-0.5	-0.5	0.9
Seeking ratio, delayed vs. immediate footshock	1.3	1.9	3.2	-0.9	-1.8	-1.0	1.6
Distance traveled before self-admin	0.1	0.3	0.9	-0.2	-0.4	-0.9	0.1
Distance traveled after self-admin	0.9	1.5	2.2	-1.5	-1.3	-1.2	0.8
Extensor digitorum longus weight	0.0	0.1	0.2	0.1	0.3	0.1	-0.5
Bone: elastic displacement	0.2	0.2	0.4	0.7	0.2	0.5	0.3
Bone: elastic work	0.0	0.0	0.1	0.0	-0.4	-0.1	-0.2
Bone: endosteal estimation	0.4	1.0	2.1	-1.4	-0.7	-0.4	-1.2
Bone: endosteal perimeter	0.2	0.6	1.9	0.2	0.5	0.5	-1.4
Epididymis fat weight	4.4	22.3	27.4	-4.2	-4.5	-5.2	4.9
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.3	-0.2	-0.5	-0.6
Delta time in open arm before/after self-admin	0.0	0.1	0.1	-0.2	-0.3	0.0	0.3
Diff in mean of infusions in LGA sessions	0.7	1.2	2.0	1.4	1.3	0.8	-0.7
Delay discount exponential model param	0.0	0.1	0.1	-0.3	0.0	-0.3	0.3
Extinction: sum of active levers before priming	0.7	1.1	2.1	0.8	1.0	0.9	-1.4
Active lever presses in extinction session 6	0.2	0.2	0.6	0.8	0.4	0.2	-0.3
Bone: final force	2.9	4.7	6.1	-2.2	-2.4	-2.5	1.4
Bone: final moment	2.1	3.4	4.4	-1.9	-2.0	-2.1	1.3
Food consumed during 24 hour testing period	0.4	0.8	1.7	-1.3	-0.7	-0.9	-0.2
Glucose	2.7	4.3	5.0	1.7	2.2	2.2	-2.1
Heart weight	0.3	0.5	1.4	-0.4	-1.2	-0.4	0.2
Delay discount hyperbolic model param	0.1	0.1	0.1	-0.3	-0.0	-0.4	0.3
Intermittent access intake day 1-15 change	0.0	0.2	0.5	-0.7	-0.2	-0.1	0.5
Intermittent access intake escalation	0.1	0.6	1.1	-0.8	-0.6	-0.4	1.1
Intermittent access intake escalation 2	0.1	0.1	0.2	-0.3	0.3	0.4	-0.2
Intermitt. access day 1 inactive lever presses	0.0	0.6	0.9	-0.9	0.7	0.3	-0.9
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.5	-0.7	-0.4	-0.4	-0.1
Intermitt. access escalation Index	0.3	1.0	1.5	1.2	1.1	0.9	-0.8
Intermittent access day 1 total infusions	1.0	2.9	4.5	2.1	1.7	1.6	-1.4
Intermittent access day 15 total infusions	0.1	0.2	0.4	0.6	0.5	0.6	0.1
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.6	0.3	0.5	-0.1
Intermittent access total infusions	0.5	0.5	0.9	1.0	0.7	0.8	-0.3
Intermittent access day 1 locomotion	0.1	0.2	0.8	0.9	0.2	-0.1	-0.0
Intermittent access day 15 total locomotion	0.2	0.8	1.3	-0.5	-1.2	-1.1	0.7
Intermittent access total locomotion	0.2	0.2	0.4	0.0	-0.6	-0.6	0.5
Intermittent access standard deviation	0.6	3.0	4.8	-2.2	-1.7	-1.6	1.3
Left kidney weight	1.6	12.5	15.6	-3.5	-3.9	-3.8	2.8
Right kidney weight	1.8	12.8	15.5	-3.6	-3.9	-3.9	2.8
Cocaine induced anxiety	0.0	0.1	0.2	-0.1	0.2	-0.1	-0.4
Post-drug Anxiety	0.1	0.2	0.3	-0.4	-0.4	-0.6	0.2
Baseline Anxiety	0.1	0.1	0.2	-0.3	-0.4	-0.3	-0.0
Tail length	0.2	1.1	2.0	-1.4	-1.4	-0.6	0.4
Length with tail	0.6	2.8	4.6	-2.1	-2.1	-1.5	0.1
Length without tail	1.1	5.8	9.4	-3.1	-2.5	-2.8	-0.0
Times rat made contact with spout	0.4	0.4	1.2	0.5	0.3	0.5	1.1
Lifetime Intake	0.4	0.6	1.1	1.1	0.7	0.7	-0.3
Liver weight, left	0.3	0.5	1.4	-1.2	-0.5	-0.7	-0.2
Liver weight, right	0.6	1.1	4.2	-0.2	0.2	0.2	-2.1
Locomotor activity	0.4	0.6	0.9	-1.0	-0.6	-0.2	1.0
Locomotor testing distance	0.2	0.4	0.8	-0.9	-0.4	-0.3	0.6
Locomotor testing rearing	0.2	0.8	1.6	-1.3	-0.8	-0.8	0.3
Locomotion in novel chamber	0.2	0.2	0.5	-0.7	-0.3	-0.3	0.5
Locomotion in novel chamber post-restriction	0.6	1.7	2.6	-1.0	-1.6	-1.5	0.9
Fecal boli incidents, locomotor time 1	0.1	0.2	0.3	0.3	0.5	0.1	-0.6
Change in fecal boli incidents, locomotor task	0.3	0.3	0.7	-0.8	-0.4	-0.1	-0.7
Time >=10cm from walls, locomotor time 1	1.5	1.9	2.8	-1.7	-1.4	-1.7	-0.3
Bouts of movement, locomotor time 1	0.1	0.2	0.3	0.5	0.3	0.3	0.5
Total resting periods, locomotor time 1	0.2	0.2	0.5	0.7	0.4	0.4	0.2
Rest time, locomotor task time 1	0.2	0.4	0.6	0.5	0.7	0.8	-0.4
Distance moved, locomotor task time 1	0.3	0.9	1.2	-1.0	-1.1	-0.9	0.5
Vertical activity count, locomotor time 1	0.3	2.2	2.9	-1.3	-1.7	-1.6	1.2
Time >=10cm from walls, locomotor time 2	0.2	0.6	0.8	-0.9	-0.8	-0.8	-0.6
Bouts of movement, locomotor time 2	0.0	0.1	0.1	0.1	0.0	0.4	0.4
Total resting periods, locomotor time 2	0.1	0.4	0.8	0.7	0.4	0.9	-0.1
Rest time, locomotor task time 2	0.4	0.7	1.2	0.4	1.0	0.6	-1.1
Distance moved, locomotor task time 2	1.1	1.5	2.0	-1.1	-1.4	-1.3	0.9
Vertical activity count, locomotor time 2	0.5	1.1	1.6	-0.9	-1.3	-1.3	0.6
Light reinforcement 1	0.5	2.5	4.2	-2.1	-1.1	-1.6	1.4
Light reinforcement 2	0.4	1.0	2.5	-1.6	-0.6	-1.0	0.5
Bone: marrow area	0.5	1.2	2.6	-1.6	-0.9	-0.5	-1.1
Bone: maximum diameter	0.7	1.4	2.4	0.9	1.0	1.1	-1.6
Bone: maximum force	1.0	2.0	3.1	-1.4	-1.6	-1.7	0.4
Bone: maximum moment	0.6	1.1	1.8	-1.1	-1.2	-1.3	0.3
Mean time between licks in bursts	0.6	3.5	5.2	1.7	1.7	1.7	-2.3
Mean num. licks in bursts	0.4	1.1	2.5	-0.1	-1.1	-0.8	1.6
Cd content in liver	0.2	0.2	0.5	-0.4	-0.1	-0.7	0.4
Co content in liver	2.5	2.9	3.2	-1.7	-1.8	-1.8	1.5
Cu content in liver	0.6	0.7	2.2	0.7	0.2	0.3	1.5
Fe content in liver	1.1	1.4	1.9	-1.2	-1.0	-1.2	1.4
K content in liver	0.5	0.4	0.8	0.8	0.9	0.6	0.2
Mg content in liver	1.7	1.9	2.7	1.3	1.6	1.4	-1.1
Mn content in liver	1.6	1.8	3.0	0.8	1.5	1.1	-1.7
Na content in liver	0.3	0.4	1.5	-0.0	-0.2	0.0	1.2
Rb content in liver	0.1	0.1	0.2	0.3	0.5	0.1	-0.1
Se content in liver	2.6	3.1	5.2	1.5	1.8	2.3	-1.2
Sr content in liver	0.1	0.1	0.2	-0.5	-0.1	-0.1	-0.0
Zn content in liver	0.2	0.2	0.3	0.2	0.5	0.3	-0.6
Bone: minimum diameter	0.1	0.2	0.9	0.3	0.1	0.1	-0.9
Time in familiar zone, hab. session 1	0.5	0.6	1.2	1.1	0.3	0.4	1.0
Time in novel zone, hab. session 1	0.5	0.6	1.7	-1.3	-0.4	-0.4	-0.6
Total zone transitions, hab. session 1	0.2	0.3	0.6	0.6	0.8	0.6	-0.1
Total locomotion distance, hab. session 1	0.2	0.3	0.6	0.8	0.6	0.5	-0.1
Locomotion velocity, hab. session 1	0.1	0.2	0.5	0.7	0.4	0.4	0.0
Time in familiar zone, hab. session 2	1.1	1.2	2.7	-0.6	-0.9	-1.0	1.6
Time in novel zone, hab. session 2	0.3	0.3	0.8	-0.1	0.4	0.6	-0.9
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.1	-0.0	-0.5	0.6
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.5	0.7	0.1	0.2
Locomotion velocity, hab. session 2	0.4	0.6	1.1	1.0	1.1	0.4	-0.1
Novel to familiar place preference ratio	0.3	0.4	0.6	0.2	0.7	0.8	-0.5
Novelty place preference	0.3	0.4	0.7	0.2	0.7	0.8	-0.6
Time in novel zone, NPP test	0.3	0.3	0.6	0.1	0.6	0.8	-0.5
Total zone transitions, NPP test	1.1	1.7	2.8	1.4	1.7	1.1	-0.8
Total locomotion distance, NPP test	0.8	1.1	2.0	1.2	1.4	0.7	-0.6
Locomotion velocity, NPP test	1.1	1.5	2.8	1.5	1.7	0.9	-0.6
Intraocular pressure	0.3	0.5	1.1	0.5	-0.6	-0.6	1.1
Delta distance traveled before/after self-admin	0.5	0.6	1.1	-1.1	-0.9	-0.0	0.7
Delta ambulatory time before/after self-admin	0.2	0.4	0.8	-0.9	-0.7	0.0	0.5
Parametrial fat weight	2.8	6.7	8.8	-3.0	-2.4	-2.8	2.1
Pavlov. Cond. lever latency	8.0	10.1	10.7	-3.3	-3.2	-3.2	3.0
Pavlov. Cond. magazine entry latency	3.7	4.7	6.1	2.2	2.1	2.5	-1.8
Pavlov. Cond. change in total contacts	2.0	2.2	2.8	1.7	1.3	1.6	-1.3
Pavlov. Cond. index score	6.4	8.2	9.0	3.0	2.9	2.9	-2.6
Pavlov. Cond. latency score	6.8	8.6	9.6	3.1	2.9	3.0	-2.7
Pavlov. Cond. lever contacts	6.4	7.8	8.2	2.8	2.9	2.6	-2.9
Pavlov. Cond. magazine entry number	2.5	3.2	4.0	-1.9	-1.8	-2.0	1.4
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.0	-0.8	-0.8	-1.0	0.9
Pavlov. Cond. lever-magazine prob. diff.	6.4	8.0	8.8	3.0	2.8	2.9	-2.6
Pavlov. Cond. response bias	4.3	5.4	6.0	2.3	2.4	2.4	-2.1
Pavlov. Cond. lever latency	0.2	0.3	0.8	-0.5	-0.1	-0.3	-0.9
Pavlov. Cond. magazine entry latency	0.5	0.8	0.9	0.8	1.0	0.9	-0.8
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.6	0.0	0.4	0.4
Pavlov. Cond. index score	0.2	0.4	0.7	0.8	0.6	0.7	-0.0
Pavlov. Cond. latency score	0.1	0.2	0.4	0.6	0.4	0.5	0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.9	0.3	-0.0	0.2	0.9
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.2
Pavlov. Cond. intertrial magazine entries	0.3	0.6	0.7	0.8	0.7	0.9	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	0.8	0.5	0.6	0.0
Pavlov. Cond. response bias	0.3	0.4	0.8	0.9	0.6	0.7	0.2
Time in closed arm before self-admin	0.1	0.1	0.3	-0.6	0.1	0.3	-0.1
Time in closed arm after self-admin	0.0	0.0	0.1	0.2	0.2	0.0	-0.2
Time in open arm before self-admin	1.1	1.3	1.9	1.2	1.1	1.4	-0.9
Time in open arm after self-admin	0.2	0.2	0.6	0.1	0.3	0.7	-0.5
Bone: periosteal estimation	0.3	0.8	1.3	-1.1	-1.0	-0.7	-0.5
Bone: periosteal perimeter	0.0	0.1	0.3	0.1	-0.0	0.2	-0.6
Bone: post-yield work	0.3	0.5	1.9	-0.1	0.4	0.1	-1.4
Progressive ratio test 1 active lever presses	0.2	0.4	0.5	0.7	0.7	0.6	-0.6
Progressive ratio test 1 breakpoint	0.2	0.4	0.5	0.6	0.7	0.6	-0.6
Progressive ratio test 1 inactive lever presses	0.2	0.4	0.7	-0.7	-0.4	-0.8	0.6
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.5	0.7	0.5	-0.2
Progressive ratio test 2 breakpoint	0.2	0.3	0.4	0.5	0.7	0.5	-0.2
Progressive ratio test 2 inactive lever presses	0.5	1.6	2.2	0.8	1.4	1.2	-1.5
Incentive Sensitization - Responses	0.1	0.2	0.4	0.3	0.6	0.6	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.2	0.5	0.5	-0.1
Sum of active levers in priming session hrs 5-6	0.6	0.5	0.8	0.8	0.7	0.9	-0.4
Progressive ratio	2.8	8.3	10.1	-3.0	-3.2	-2.9	2.5
Food seeking constrained by brief footshock	0.0	0.1	0.1	-0.2	-0.3	0.0	0.3
Seeking ratio, punishment vs. effort	2.5	5.5	6.6	2.3	2.6	2.5	-2.0
Retroperitoneal fat weight	0.1	0.6	1.2	-0.9	-0.6	-1.1	0.4
Reaction time number correct	0.8	2.7	4.0	-2.0	-1.7	-1.7	1.2
Reaction time mean minus median	0.5	3.5	6.6	2.6	1.9	1.9	-0.5
Reaction time mean minus median AUC	0.8	5.0	9.1	3.0	2.3	2.2	-1.0
Reaction time num false alarms	0.1	0.1	0.2	0.4	0.2	0.4	-0.4
Reaction time num false alarms AUC	0.0	0.1	0.1	0.3	-0.0	0.3	-0.2
Reaction time trials correct on left	0.8	2.7	4.0	-2.0	-1.7	-1.7	1.2
Reaction time trials on left	0.8	2.6	3.7	-1.9	-1.6	-1.6	1.1
Reaction time mean	1.8	3.9	4.9	2.2	2.1	1.8	-1.9
Reaction time mean AUC	1.6	3.9	5.2	2.3	2.0	1.7	-1.8
Median of all reaction times	1.7	2.6	3.6	1.6	1.6	1.3	-1.9
Reaction time omissions	1.1	1.7	2.7	1.7	1.5	1.1	-0.9
Reaction time false alarm rate	1.1	1.6	2.3	1.5	1.0	1.4	-1.0
Reaction time premature initiation rate	0.2	0.4	1.1	-1.0	-0.5	-0.4	-0.0
Reaction time premature initiations	0.8	2.3	4.5	-2.1	-1.5	-1.4	0.6
Std. dev. reaction times	1.4	4.6	7.2	2.7	2.2	2.2	-1.2
Reaction time trials completed	0.8	2.6	3.7	-1.9	-1.6	-1.6	1.1
Reaction time trials AUC	0.8	2.7	4.0	-2.0	-1.6	-1.7	1.2
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.3	-0.2	-0.4	0.5
Run reversals in cocaine runway, males	1.0	1.1	1.6	0.7	1.3	1.1	-1.0
Latency to leave start box in cocaine runway	0.7	1.0	2.1	0.6	1.0	0.8	-1.4
Latency to leave start box in cocaine runway, F	0.6	0.8	1.3	0.8	0.8	0.7	-1.2
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	-0.3	0.2	0.0	-0.7
Std. dev. time between licks in bursts	1.2	2.3	4.9	1.1	1.1	1.3	-2.2
Total sessions with >9 infusions	0.5	0.7	1.8	1.4	0.5	0.7	-0.3
Short access day 1 total inactive lever presses	0.9	1.9	2.8	1.1	1.3	1.3	-1.7
Short access day 10 total inactive lever presses	0.0	0.1	0.4	-0.6	0.3	-0.1	0.2
Short access day 1 total infusions	1.0	1.9	2.5	1.6	1.2	1.4	-1.3
Short access day 10 total infusions	0.3	0.5	1.7	1.3	0.5	0.5	-0.1
Short access total infusions	1.0	1.4	3.1	1.8	1.0	1.0	-0.7
Short access day 1 locomotion	0.7	1.2	2.3	1.5	1.0	0.8	-0.8
Short access day 10 total locomotion	0.2	0.7	1.0	-1.0	-1.0	-0.9	-0.1
Short access total locomotion	0.1	0.2	0.6	0.5	0.0	-0.0	-0.8
One hour access (0.3 mA shock)	0.7	0.8	1.7	0.8	1.3	1.0	-0.1
Compulsive drug intake	0.4	0.6	1.2	-0.1	1.0	0.4	-1.1
One hour access (shock baseline)	0.1	0.3	0.4	0.6	0.2	0.3	0.7
Social response proportion	0.2	0.3	0.9	-0.5	-0.2	-0.0	-0.9
Social responses	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.3
Social time	0.8	1.3	1.8	1.0	1.3	1.0	-1.3
Soleus weight	0.7	2.0	6.0	0.2	1.1	0.8	-2.5
Bone: stiffness	1.1	2.0	3.0	-1.4	-1.5	-1.7	0.8
Tibialis anterior weight	0.3	0.9	1.2	-0.8	-1.0	-1.1	1.0
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.0	0.3	-0.5	-1.0	1.0
Time to tail flick, vehicle, after self-admin	0.5	1.0	1.7	1.3	0.8	1.0	-0.7
Time to tail flick, test, before self-admin	0.5	0.6	2.0	-0.4	-0.4	-0.3	1.4
Time to tail flick, test, after self-admin	0.9	0.9	1.6	0.8	1.2	1.3	-0.2
Delta time to tail flick, vehicle, before/after SA	1.7	1.8	2.7	1.3	1.4	1.6	-1.0
Delta time to tail flick, test, before/after SA	0.2	0.3	0.5	0.5	0.7	0.3	-0.5
Tibia length	0.7	1.8	4.1	-2.0	-1.1	-1.1	-0.8
Ambulatory time before self-admin	0.0	0.1	0.1	0.3	0.1	-0.3	-0.1
Ambulatory time after self-admin	0.3	0.5	0.7	-0.8	-0.8	-0.6	0.4
Bone: tissue strength	0.1	0.1	0.1	-0.2	-0.2	-0.3	0.1
Total heroin consumption	0.0	0.0	0.1	-0.1	0.1	0.1	0.3
Bone: trabecular number	0.4	0.8	1.8	1.3	1.0	0.4	0.3
Bone: trabecular spacing	0.7	1.0	1.9	-1.4	-1.3	-0.7	0.0
Bone: trabecular thickness	0.1	0.1	0.3	0.6	0.4	-0.1	0.2
Bone: trabecular tissue density	0.1	0.2	0.4	-0.1	0.3	0.6	-0.3
Water consumed over 24 hours	0.1	0.1	0.3	-0.0	0.4	0.4	-0.5
Number of responses in last shaping day	1.0	1.3	3.3	0.4	0.6	1.2	-1.8