Hub : Genes

Btbd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Btbd2	0.05	0.04	6.9e-03	0.02	0.01	0.01	0.02	3.1e-03	3.8e-02	2.5e-02	1.1e-02
2	Adipose	gene expression	Btbd2	0.05	0.04	5.3e-07	0.05	0.05	0.05	0.05	3.3e-06	2.8e-06	4.4e-06	2.8e-06
3	PL	intron excision ratio	chr7_9072719_9073211	0.07	0.05	2.5e-03	0.03	0.02	0.02	0.02	5.0e-04	1.4e-03	2.8e-03	9.8e-04
4	PL	intron excision ratio	chr7_9072719_9073229	0.07	0.05	3.1e-03	0.02	0.02	0.02	0.02	1.5e-03	1.8e-03	3.6e-03	2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.9	3.2	5.6	1.0	-0.9	2.4	-2.4
Area under the delay curve	1.3	1.4	2.8	-1.6	-1.7	0.3	-0.3
BMI with tail	3.5	11.5	23.1	-4.8	-4.4	-1.4	1.4
BMI without tail	2.2	4.6	9.1	-3.0	-1.7	-1.8	1.8
Body weight	0.7	2.8	6.1	-2.5	-2.1	-0.6	0.6
Weight adjusted by age	1.2	1.3	1.9	-1.2	-0.2	-1.4	1.4
Bone surface	4.1	7.3	12.4	2.0	-0.7	3.5	-3.5
Bone volume	4.2	7.2	12.4	1.9	-0.7	3.5	-3.5
Breakpoint value in progressive ratio session	2.9	3.2	7.2	2.1	2.7	-0.7	0.7
Number of licking bursts	1.2	1.4	2.5	-0.7	0.3	-1.6	1.6
Context. condit. distance diff. score	0.2	0.3	0.6	-0.8	-0.5	-0.3	0.3
Locomotion velocity, session 1	1.8	1.9	3.0	1.3	0.3	1.7	-1.7
Locomotion distance, session 1	2.4	3.0	5.0	1.4	-0.4	2.2	-2.2
Locomotion velocity, session 2	5.3	6.1	9.1	3.0	1.3	2.6	-2.6
Locomotion distance, session 2	3.7	5.2	6.8	2.6	0.7	2.6	-2.6
Locomotion velocity, session 3	2.9	3.4	7.3	2.5	2.7	0.1	-0.1
Locomotion distance, session 3	0.0	0.0	0.1	-0.3	0.1	-0.2	0.2
Stereotopy head waving bouts, day 3	2.8	3.3	7.5	2.7	2.1	0.8	-0.8
Stereotopy head waving duration, day 3	3.1	3.7	8.1	2.8	2.4	0.6	-0.6
Locomotion velocity, session 7	0.4	0.4	0.6	0.4	0.8	0.6	-0.6
Locomotion distance, session 7	0.4	0.5	1.0	-1.0	0.0	-0.8	0.8
Stereotopy head waving bouts, day 7	0.9	1.0	1.7	0.6	-0.4	1.3	-1.3
Stereotopy head waving duration, day 7	1.1	1.4	2.2	1.0	-0.0	1.5	-1.5
Locomotion velocity, session 8	2.5	3.0	4.9	1.6	0.1	2.2	-2.2
Locomotion distance, session 8	0.3	0.5	0.7	0.8	0.1	0.8	-0.8
Degree of sensitization distance	0.2	0.2	0.4	-0.6	-0.6	0.0	-0.0
Degree of sensitization stereotypy	1.3	1.4	2.8	-1.0	-1.7	1.0	-1.0
Conditioned locomotion	2.1	2.5	3.4	-1.9	-0.8	-1.7	1.7
Cocaine response after cond. corrected	4.8	5.4	11.3	-3.4	-1.8	-1.9	1.9
Cocaine response after cond. not corrected	5.2	5.7	11.8	-3.4	-1.8	-1.9	1.9
Cocaine response before conditioning	0.4	0.5	0.7	0.8	0.6	0.7	-0.7
Saline control response	0.1	0.2	0.3	-0.3	-0.1	-0.5	0.5
Bone: connectivity density	1.3	2.0	3.2	0.3	-1.1	1.8	-1.8
Bone: cortical apparent density	0.3	0.5	0.9	-0.9	-1.0	-0.3	0.3
Bone: cortical area	0.8	1.2	1.5	-0.5	-1.2	1.2	-1.2
Bone: cortical porosity	0.7	0.8	1.1	1.0	0.5	0.9	-0.9
Bone: cortical porosity	1.1	1.2	2.1	0.7	-0.3	1.5	-1.5
Bone: cortical thickness	0.6	1.0	2.3	-1.0	-1.5	0.6	-0.6
Bone: cortical thickness	0.5	0.6	0.9	-0.6	0.4	-0.9	0.9
Bone: cortical tissue density	0.2	0.3	0.6	-0.7	-0.8	-0.3	0.3
Condit. Reinf. active minus inactive responses	2.1	2.4	4.9	2.2	2.1	0.4	-0.4
Condit. Reinf. active-inactive response ratio	1.1	1.1	2.9	1.1	1.7	-0.4	0.4
Condit. Reinf. active responses	2.6	3.2	7.1	2.7	1.8	1.2	-1.2
Condit. Reinf. inactive responses	1.6	1.9	3.3	1.8	0.5	1.4	-1.4
Incentive salience index mean	1.6	2.0	4.2	2.1	1.3	1.0	-1.0
Condit. Reinf. lever presses	1.5	2.0	3.3	1.1	-0.6	1.8	-1.8
Condit. Reinf. active minus inactive responses	1.4	1.7	3.9	1.1	2.0	-1.0	1.0
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.7	-0.3	0.7	-1.6	1.6
Condit. Reinf. active responses	0.9	1.3	3.4	1.3	1.8	-0.2	0.2
Condit. Reinf. inactive responses	0.6	0.8	1.1	1.0	1.1	0.7	-0.7
Condit. Reinf. lever presses	1.2	1.6	4.0	1.2	2.0	-0.7	0.7
Condit. Reinf. lever reinforcers received	0.8	1.1	3.0	0.9	1.7	-0.5	0.5
Conditioned reinforcement - actives	1.1	1.1	2.4	1.4	1.6	0.2	-0.2
Conditioned reinforcement - inactives	0.5	0.6	1.1	-1.1	-0.5	-0.7	0.7
Conditioned locomotion	3.5	4.2	9.1	2.8	3.0	0.2	-0.2
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.3	-0.5	0.1	-0.1
Patch foraging indifference point AUC	0.4	0.5	1.3	0.8	1.1	-0.2	0.2
Delay disc. indifference point, 0s delay	4.7	5.2	10.9	-1.7	-3.3	1.9	-1.9
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	-0.3	-0.4	0.0	-0.0
Delay disc. indifference point, 2s delay	3.0	3.4	7.7	-2.1	-2.8	0.8	-0.8
Delay disc. indifference point, 24s delay	0.6	0.6	1.2	-1.1	-0.7	-0.6	0.6
Delay disc. indifference point, 4s delay	0.7	0.8	1.7	-0.8	-1.3	0.6	-0.6
Delay disc. indifference point, 8s delay	1.0	1.0	2.6	-1.6	-1.0	-0.5	0.5
Indifference point function ln k	0.2	0.3	0.7	-0.8	-0.5	-0.3	0.3
Indifference point function log k	0.2	0.3	0.7	-0.8	-0.5	-0.3	0.3
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	-0.3	-0.4	-0.1	0.1
Patch foraging total patch changes 12 sec	0.8	1.0	1.5	-0.9	-0.3	-1.2	1.2
Patch foraging total patch changes 18 sec	0.6	0.7	1.5	1.2	1.2	-0.1	0.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.1	0.4	0.3	-0.2	0.2
Patch foraging total patch changes 6 sec	0.1	0.2	0.5	0.7	0.5	0.0	-0.0
Patch foraging time to switch 0 sec	1.3	2.0	3.6	-0.2	-1.9	1.5	-1.5
Patch foraging water rate 0 sec	1.2	2.0	3.1	-1.1	0.7	-1.8	1.8
Patch foraging water rate 12 sec	2.2	3.4	4.7	-2.2	-0.6	-2.1	2.1
Patch foraging water rate 18 sec	4.2	5.6	9.7	-1.3	1.2	-3.1	3.1
Patch foraging water rate 24 sec	3.5	4.9	7.7	-2.0	0.4	-2.8	2.8
Patch foraging water rate 6 sec	1.6	2.3	3.8	-0.5	1.2	-1.9	1.9
Seeking ratio, delayed vs. immediate footshock	2.5	2.9	5.8	2.4	2.1	0.8	-0.8
Distance traveled before self-admin	0.4	0.4	0.6	-0.5	-0.8	0.6	-0.6
Distance traveled after self-admin	0.4	0.5	0.8	0.9	0.8	0.5	-0.5
Extensor digitorum longus weight	2.9	11.3	23.9	-4.9	-3.8	-1.9	1.9
Bone: elastic displacement	0.2	0.2	0.4	0.6	0.5	0.3	-0.3
Bone: elastic work	0.3	0.4	0.4	-0.5	-0.6	0.7	-0.7
Bone: endosteal estimation	0.2	0.3	0.6	-0.4	-0.8	0.5	-0.5
Bone: endosteal perimeter	0.4	0.8	1.3	0.9	0.3	1.1	-1.1
Epididymis fat weight	0.3	0.6	0.7	0.7	0.8	-0.8	0.8
Delta time in closed arm before/after self-admin	4.0	3.8	6.1	-1.8	-0.1	-2.5	2.5
Delta time in open arm before/after self-admin	0.7	0.7	1.5	-0.8	-1.2	0.6	-0.6
Diff in mean of infusions in LGA sessions	1.0	1.1	2.3	1.5	1.4	0.0	-0.0
Delay discount exponential model param	1.2	1.2	2.5	1.6	1.6	-0.1	0.1
Extinction: sum of active levers before priming	1.4	1.4	2.1	0.6	1.5	-1.2	1.2
Active lever presses in extinction session 6	1.5	1.4	2.7	1.6	1.6	0.4	-0.4
Bone: final force	0.9	1.5	2.8	-1.2	-1.7	1.0	-1.0
Bone: final moment	0.8	1.3	2.3	-1.0	-1.5	1.0	-1.0
Food consumed during 24 hour testing period	0.4	0.5	1.1	-1.1	-0.7	-0.4	0.4
Glucose	0.8	1.2	2.5	-1.6	-1.3	-0.5	0.5
Heart weight	0.4	0.6	0.8	0.2	0.9	-0.8	0.8
Delay discount hyperbolic model param	1.6	1.7	3.5	1.8	1.9	-0.2	0.2
Intermittent access intake day 1-15 change	3.1	3.1	7.5	2.2	2.7	-0.2	0.2
Intermittent access intake escalation	3.5	3.5	8.5	1.7	2.9	-1.1	1.1
Intermittent access intake escalation 2	4.3	4.2	10.2	2.0	3.2	-1.2	1.2
Intermitt. access day 1 inactive lever presses	0.5	0.5	0.7	-0.3	0.8	-0.9	0.9
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.7	0.5	0.8	-0.3	0.3
Intermitt. access escalation Index	0.9	0.8	1.3	0.1	-0.8	1.2	-1.2
Intermittent access day 1 total infusions	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2
Intermittent access day 15 total infusions	1.0	1.1	2.9	1.0	1.7	-0.5	0.5
Intermittent access terminal intake (last 3 days)	0.5	0.5	1.4	0.8	1.2	-0.1	0.1
Intermittent access total infusions	0.1	0.1	0.3	0.2	0.6	-0.2	0.2
Intermittent access day 1 locomotion	0.2	0.2	0.5	0.5	0.7	-0.1	0.1
Intermittent access day 15 total locomotion	1.8	1.9	4.3	1.8	2.1	-0.1	0.1
Intermittent access total locomotion	0.5	0.6	1.2	1.0	1.1	0.2	-0.2
Intermittent access standard deviation	1.4	1.5	4.0	1.2	2.0	-0.5	0.5
Left kidney weight	0.2	0.6	1.0	0.5	-0.1	1.0	-1.0
Right kidney weight	0.7	2.1	3.9	2.0	1.9	0.7	-0.7
Cocaine induced anxiety	1.0	1.2	1.6	1.3	0.4	1.2	-1.2
Post-drug Anxiety	1.2	1.3	1.9	1.3	0.2	1.4	-1.4
Baseline Anxiety	0.3	0.3	0.6	-0.0	0.5	-0.8	0.8
Tail length	1.4	4.2	10.4	2.5	3.2	-0.3	0.3
Length with tail	1.1	3.9	7.0	2.6	2.4	1.2	-1.2
Length without tail	0.7	1.6	2.7	0.9	-0.1	1.6	-1.6
Times rat made contact with spout	0.7	0.8	1.2	-0.9	-0.2	-1.1	1.1
Lifetime Intake	0.0	0.0	0.1	0.1	0.3	-0.1	0.1
Liver weight, left	1.4	2.2	4.0	-2.0	-1.8	-1.0	1.0
Liver weight, right	0.8	1.3	3.1	-1.4	-1.8	0.0	-0.0
Locomotor activity	2.4	3.8	7.3	2.7	1.8	1.5	-1.5
Locomotor testing distance	1.2	2.0	4.1	2.0	1.6	0.9	-0.9
Locomotor testing rearing	0.3	0.4	0.8	-0.3	0.4	-0.9	0.9
Locomotion in novel chamber	0.5	0.6	0.8	0.3	0.8	-0.9	0.9
Locomotion in novel chamber post-restriction	0.4	0.5	1.1	0.7	1.0	-0.5	0.5
Fecal boli incidents, locomotor time 1	1.0	1.1	2.5	-1.6	-1.1	-0.6	0.6
Change in fecal boli incidents, locomotor task	0.5	0.5	0.9	0.4	0.2	0.9	-0.9
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.3	-0.4	-0.9	1.1	-1.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.2	0.5	-0.0	0.0
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.4	0.5	0.2	-0.2
Rest time, locomotor task time 1	0.2	0.2	0.5	0.7	0.4	0.4	-0.4
Distance moved, locomotor task time 1	0.7	0.7	1.0	-0.3	-1.0	1.0	-1.0
Vertical activity count, locomotor time 1	0.3	0.3	0.8	-0.9	-0.1	-0.5	0.5
Time >=10cm from walls, locomotor time 2	1.0	1.1	2.8	-1.7	-0.9	-0.6	0.6
Bouts of movement, locomotor time 2	1.3	1.4	1.9	1.3	0.3	1.4	-1.4
Total resting periods, locomotor time 2	1.3	1.4	1.9	1.3	0.2	1.4	-1.4
Rest time, locomotor task time 2	0.6	0.7	1.2	1.1	0.5	0.8	-0.8
Distance moved, locomotor task time 2	0.7	0.8	1.2	-1.1	-0.7	-0.8	0.8
Vertical activity count, locomotor time 2	1.3	1.4	2.1	-1.5	-0.5	-1.3	1.3
Light reinforcement 1	3.4	6.2	13.9	3.7	3.0	0.9	-0.9
Light reinforcement 2	1.4	1.9	4.0	2.0	1.5	0.9	-0.9
Bone: marrow area	0.2	0.3	0.7	-0.5	-0.8	0.5	-0.5
Bone: maximum diameter	1.1	2.0	2.6	1.5	0.6	1.6	-1.6
Bone: maximum force	0.8	1.4	2.7	-1.4	-1.6	0.8	-0.8
Bone: maximum moment	0.7	1.2	2.2	-1.2	-1.5	0.8	-0.8
Mean time between licks in bursts	2.1	3.0	6.6	2.2	2.6	-0.5	0.5
Mean num. licks in bursts	0.2	0.2	0.4	-0.0	-0.3	0.6	-0.6
Cd content in liver	0.2	0.2	0.3	-0.3	-0.5	0.4	-0.4
Co content in liver	0.3	0.3	0.8	0.7	0.9	-0.2	0.2
Cu content in liver	1.1	1.4	2.5	0.2	-0.7	1.6	-1.6
Fe content in liver	0.1	0.1	0.1	-0.1	0.3	-0.4	0.4
K content in liver	0.9	0.9	1.5	0.6	-0.4	1.2	-1.2
Mg content in liver	1.0	1.0	1.8	0.6	-0.5	1.3	-1.3
Mn content in liver	4.2	4.7	7.7	1.9	0.2	2.8	-2.8
Na content in liver	1.0	1.1	1.8	-0.3	-1.3	1.1	-1.1
Rb content in liver	1.1	1.4	2.2	0.0	-1.1	1.5	-1.5
Se content in liver	0.2	0.2	0.3	0.6	0.4	0.4	-0.4
Sr content in liver	0.8	0.8	1.4	-0.4	0.4	-1.2	1.2
Zn content in liver	2.6	2.9	3.8	0.5	2.0	-1.9	1.9
Bone: minimum diameter	0.2	0.3	0.6	0.1	-0.3	0.8	-0.8
Time in familiar zone, hab. session 1	1.2	1.1	2.6	1.1	1.6	-0.6	0.6
Time in novel zone, hab. session 1	1.4	1.4	1.8	-0.6	-1.3	1.3	-1.3
Total zone transitions, hab. session 1	2.0	2.8	3.7	1.9	0.6	1.9	-1.9
Total locomotion distance, hab. session 1	3.7	5.2	7.9	2.2	0.4	2.8	-2.8
Locomotion velocity, hab. session 1	3.2	4.5	5.9	2.4	0.7	2.4	-2.4
Time in familiar zone, hab. session 2	3.3	3.4	8.1	1.9	2.8	-0.9	0.9
Time in novel zone, hab. session 2	2.8	2.8	6.1	-1.7	-2.5	1.0	-1.0
Total zone transitions, hab. session 2	2.6	3.4	5.8	1.0	-1.1	2.4	-2.4
Total locomotion distance, hab. session 2	2.1	2.8	4.1	2.0	0.5	1.9	-1.9
Locomotion velocity, hab. session 2	2.9	3.9	5.4	2.2	0.4	2.3	-2.3
Novel to familiar place preference ratio	2.9	3.0	6.0	-1.5	-2.4	1.4	-1.4
Novelty place preference	2.1	2.2	3.8	-1.1	-2.0	1.4	-1.4
Time in novel zone, NPP test	2.2	2.2	4.2	-1.3	-2.0	1.3	-1.3
Total zone transitions, NPP test	1.0	1.5	2.3	1.0	-0.5	1.5	-1.5
Total locomotion distance, NPP test	1.5	2.0	3.5	0.8	-0.6	1.9	-1.9
Locomotion velocity, NPP test	1.5	2.1	3.4	1.1	-0.3	1.9	-1.9
Intraocular pressure	1.4	2.0	3.5	-0.7	0.7	-1.9	1.9
Delta distance traveled before/after self-admin	0.8	0.9	1.8	1.4	1.3	0.2	-0.2
Delta ambulatory time before/after self-admin	1.0	1.1	2.3	1.5	1.3	0.5	-0.5
Parametrial fat weight	0.2	0.4	1.1	0.4	1.0	-0.3	0.3
Pavlov. Cond. lever latency	0.6	0.8	1.4	-0.5	0.5	-1.2	1.2
Pavlov. Cond. magazine entry latency	1.5	1.9	4.0	1.9	2.0	-0.2	0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.2	0.4	0.2	0.0	-0.0
Pavlov. Cond. index score	0.5	0.6	1.2	1.1	0.4	0.7	-0.7
Pavlov. Cond. latency score	0.8	1.0	1.5	1.2	0.3	1.1	-1.1
Pavlov. Cond. lever contacts	1.0	1.2	2.0	0.8	-0.3	1.4	-1.4
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	-1.1	-0.9	0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.1	-0.0	0.7	-1.1	1.1
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.7	1.3	0.7	0.6	-0.6
Pavlov. Cond. response bias	0.6	0.7	1.7	1.3	1.1	0.2	-0.2
Pavlov. Cond. lever latency	0.3	0.4	1.0	-0.6	-1.0	-0.4	0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	0.5	0.7	0.4	-0.4
Pavlov. Cond. change in total contacts	0.3	0.4	1.2	0.6	1.1	0.0	-0.0
Pavlov. Cond. index score	0.3	0.4	1.2	0.6	1.1	0.2	-0.2
Pavlov. Cond. latency score	0.4	0.5	0.9	0.7	1.0	0.5	-0.5
Pavlov. Cond. lever contacts	0.3	0.4	1.2	0.4	1.1	-0.1	0.1
Pavlov. Cond. magazine entry number	0.4	0.4	0.8	-0.7	-0.9	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.7	0.9	-0.9	-0.3	-0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	0.7	1.0	0.4	-0.4
Pavlov. Cond. response bias	0.7	1.0	2.9	0.9	1.7	-0.2	0.2
Time in closed arm before self-admin	1.4	1.6	2.3	-0.1	-1.3	1.5	-1.5
Time in closed arm after self-admin	0.1	0.1	0.1	0.0	0.2	-0.3	0.3
Time in open arm before self-admin	0.5	0.5	1.2	0.6	1.1	-0.6	0.6
Time in open arm after self-admin	0.4	0.4	1.0	-1.0	-0.8	-0.2	0.2
Bone: periosteal estimation	0.6	1.2	1.7	-0.3	-1.2	1.3	-1.3
Bone: periosteal perimeter	0.7	1.1	2.1	0.5	-0.2	1.4	-1.4
Bone: post-yield work	0.3	0.5	1.1	-1.1	-0.8	-0.2	0.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.3	-0.5	-0.1	-0.5	0.5
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	-0.6	-0.2	-0.4	0.4
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.0	0.2	0.1	0.2	-0.2
Progressive ratio test 2 active lever presses	0.3	0.3	0.4	-0.1	0.7	-0.7	0.7
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	0.2	0.6	-0.2	0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.2	0.2	0.2	-0.2
Incentive Sensitization - Responses	0.4	0.4	0.6	-0.2	0.7	-0.8	0.8
Incentive Sensitization - Breakpoint	0.3	0.3	0.5	-0.1	0.7	-0.7	0.7
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	0.0	0.1	-0.1
Progressive ratio	0.2	0.2	0.3	-0.4	-0.3	-0.5	0.5
Food seeking constrained by brief footshock	0.2	0.2	0.8	0.9	0.3	0.3	-0.3
Seeking ratio, punishment vs. effort	0.3	0.4	0.6	0.8	0.3	0.6	-0.6
Retroperitoneal fat weight	0.2	0.5	1.0	-1.0	-0.9	-0.4	0.4
Reaction time number correct	1.5	2.1	2.8	-1.6	-0.3	-1.7	1.7
Reaction time mean minus median	0.3	0.3	1.0	0.5	1.0	0.1	-0.1
Reaction time mean minus median AUC	0.7	1.0	1.9	0.3	-0.3	1.4	-1.4
Reaction time num false alarms	0.6	0.9	1.2	-1.1	0.0	-1.1	1.1
Reaction time num false alarms AUC	1.1	1.5	2.2	-1.3	0.0	-1.5	1.5
Reaction time trials correct on left	1.5	2.1	2.8	-1.6	-0.3	-1.7	1.7
Reaction time trials on left	1.4	1.9	2.6	-1.6	-0.4	-1.6	1.6
Reaction time mean	0.4	0.5	1.0	0.1	-0.3	1.0	-1.0
Reaction time mean AUC	0.5	0.6	1.2	0.0	-0.4	1.1	-1.1
Median of all reaction times	0.5	0.7	1.0	-0.3	-0.8	1.0	-1.0
Reaction time omissions	0.2	0.3	0.6	0.8	0.5	0.5	-0.5
Reaction time false alarm rate	0.0	0.1	0.1	-0.4	-0.1	-0.2	0.2
Reaction time premature initiation rate	0.7	1.0	2.0	0.8	1.4	-0.8	0.8
Reaction time premature initiations	1.4	2.0	3.0	-0.0	1.4	-1.7	1.7
Std. dev. reaction times	0.2	0.3	0.4	0.3	0.4	0.7	-0.7
Reaction time trials completed	1.4	1.9	2.6	-1.6	-0.4	-1.6	1.6
Reaction time trials AUC	1.7	2.5	3.5	-1.7	-0.2	-1.9	1.9
Run reversals in cocaine runway, females	0.3	0.3	0.5	0.7	0.5	0.4	-0.4
Run reversals in cocaine runway, males	1.0	1.0	2.2	1.5	1.0	0.6	-0.6
Latency to leave start box in cocaine runway	1.2	1.3	2.0	1.4	0.6	1.2	-1.2
Latency to leave start box in cocaine runway, F	2.0	2.2	4.0	0.7	-0.6	2.0	-2.0
Latency to leave start box in cocaine runway, M	2.3	2.2	3.9	1.0	2.0	-1.4	1.4
Std. dev. time between licks in bursts	0.8	1.0	1.2	1.0	0.7	1.1	-1.1
Total sessions with >9 infusions	0.2	0.2	0.4	-0.0	-0.2	0.6	-0.6
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.3	0.2	0.0	-0.0
Short access day 10 total inactive lever presses	0.2	0.2	0.3	-0.2	0.3	-0.6	0.6
Short access day 1 total infusions	0.5	0.6	0.8	0.8	0.1	0.9	-0.9
Short access day 10 total infusions	0.1	0.1	0.1	-0.2	0.3	-0.3	0.3
Short access total infusions	0.0	0.0	0.0	0.0	-0.0	0.2	-0.2
Short access day 1 locomotion	0.9	1.0	1.4	1.2	0.8	1.0	-1.0
Short access day 10 total locomotion	1.9	2.1	5.4	1.7	2.3	-0.3	0.3
Short access total locomotion	0.5	0.5	0.9	0.9	0.9	0.4	-0.4
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.5	-0.4	0.0	-0.0
Compulsive drug intake	0.7	0.7	1.6	-0.8	-1.3	0.5	-0.5
One hour access (shock baseline)	0.2	0.2	0.3	-0.2	0.5	-0.5	0.5
Social response proportion	0.9	1.0	2.0	1.4	0.6	0.9	-0.9
Social responses	4.2	5.4	10.5	3.2	2.7	1.4	-1.4
Social time	0.2	0.3	0.7	-0.6	-0.9	-0.2	0.2
Soleus weight	4.7	13.6	27.6	-5.3	-5.1	-0.8	0.8
Bone: stiffness	1.6	2.5	5.5	-2.1	-2.3	0.4	-0.4
Tibialis anterior weight	0.6	2.2	4.6	-2.1	-2.0	-0.4	0.4
Time to tail flick, vehicle, before self-admin	1.2	1.3	1.9	1.1	0.3	1.4	-1.4
Time to tail flick, vehicle, after self-admin	1.1	1.2	2.2	-0.2	0.6	-1.5	1.5
Time to tail flick, test, before self-admin	1.0	1.0	1.6	0.8	0.0	1.3	-1.3
Time to tail flick, test, after self-admin	0.4	0.5	0.6	0.8	0.3	0.8	-0.8
Delta time to tail flick, vehicle, before/after SA	2.5	2.5	4.2	-1.3	-0.1	-2.0	2.0
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	0.0	0.6	-0.7	0.7
Tibia length	0.4	1.2	2.7	1.4	1.7	-0.0	0.0
Ambulatory time before self-admin	0.2	0.2	0.4	-0.5	-0.7	0.4	-0.4
Ambulatory time after self-admin	0.3	0.3	0.5	0.7	0.5	0.5	-0.5
Bone: tissue strength	0.8	0.8	1.9	-1.0	-1.4	0.2	-0.2
Total heroin consumption	1.0	1.2	2.4	1.6	1.5	0.1	-0.1
Bone: trabecular number	1.5	2.4	3.5	1.6	0.4	1.9	-1.9
Bone: trabecular spacing	3.5	4.5	7.4	-1.8	0.1	-2.7	2.7
Bone: trabecular thickness	5.0	5.9	10.4	1.4	-1.1	3.2	-3.2
Bone: trabecular tissue density	1.2	1.8	2.5	-1.6	-1.3	-1.2	1.2
Water consumed over 24 hours	0.7	0.8	1.1	-0.5	-1.1	1.0	-1.0
Number of responses in last shaping day	0.1	0.1	0.2	0.2	0.4	0.2	-0.2