Btbd10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	mRNA stability	Btbd10	0.14	0.08	4.0e-03	0.11	0.12	0.1	0.11	1.4e-03	1.0e-03	2.1e-03	1.1e-03
2	BLA	isoform ratio	NM_001399402.1	0.06	0.04	6.7e-03	0.02	0.04	0.04	0.03	2.1e-02	4.1e-03	5.4e-03	1.7e-02
3	Adipose	mRNA stability	Btbd10	0.03	0.02	6.0e-03	0.01	0.01	-0	0.01	1.9e-02	1.3e-02	7.1e-01	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.1	0.2	0.6	-0.1	0.2	-0.8
Area under the delay curve	0.0	0.0	0.0	0.2	-0.1	0.1
BMI with tail	4.5	15.4	29.4	4.0	-5.4	0.6
BMI without tail	2.2	6.7	12.2	2.8	-3.5	0.4
Body weight	0.8	3.6	7.3	1.8	-2.7	-0.5
Weight adjusted by age	0.8	1.2	2.9	0.5	-0.7	1.7
Bone surface	0.0	0.1	0.1	0.2	-0.0	-0.4
Bone volume	0.2	0.3	0.6	0.7	-0.7	-0.2
Breakpoint value in progressive ratio session	0.0	0.0	0.0	0.0	0.2	0.0
Number of licking bursts	0.4	0.7	1.5	-0.2	0.6	1.2
Context. condit. distance diff. score	0.2	0.3	0.4	0.6	-0.3	0.6
Locomotion velocity, session 1	0.5	0.6	0.9	1.0	-0.4	0.8
Locomotion distance, session 1	4.6	5.8	7.4	2.6	-2.7	1.8
Locomotion velocity, session 2	0.3	0.4	0.6	0.8	-0.4	0.5
Locomotion distance, session 2	5.7	7.9	10.9	3.1	-3.3	1.9
Locomotion velocity, session 3	0.1	0.1	0.3	-0.1	-0.3	0.5
Locomotion distance, session 3	0.1	0.1	0.2	-0.4	0.1	0.4
Stereotopy head waving bouts, day 3	1.3	1.6	3.4	0.7	-0.9	1.9
Stereotopy head waving duration, day 3	0.6	0.7	1.5	0.6	-0.5	1.2
Locomotion velocity, session 7	0.1	0.1	0.3	0.1	0.2	-0.6
Locomotion distance, session 7	0.3	0.3	0.6	-0.5	0.8	-0.4
Stereotopy head waving bouts, day 7	0.6	0.6	0.9	-0.6	1.0	0.8
Stereotopy head waving duration, day 7	0.2	0.3	0.4	0.6	-0.2	0.6
Locomotion velocity, session 8	0.7	0.9	2.0	0.1	0.7	1.4
Locomotion distance, session 8	2.9	4.3	5.4	2.3	-2.2	1.6
Degree of sensitization distance	0.3	0.3	0.7	0.9	-0.3	0.3
Degree of sensitization stereotypy	0.2	0.3	0.6	-0.4	0.8	0.1
Conditioned locomotion	0.3	0.3	0.5	-0.5	-0.4	-0.7
Cocaine response after cond. corrected	0.1	0.2	0.4	-0.2	0.3	-0.7
Cocaine response after cond. not corrected	0.9	1.0	2.9	-0.3	-0.2	-1.7
Cocaine response before conditioning	0.9	1.0	2.5	0.0	-0.8	-1.6
Saline control response	0.2	0.3	0.4	-0.6	0.6	-0.3
Bone: connectivity density	0.3	0.4	1.2	-0.1	0.1	-1.1
Bone: cortical apparent density	2.1	2.9	4.6	-1.8	2.1	-0.9
Bone: cortical area	0.6	0.9	1.4	1.2	-1.2	-0.0
Bone: cortical porosity	0.7	0.8	1.4	-1.2	0.2	-0.9
Bone: cortical porosity	1.9	2.1	3.6	-1.9	1.2	-1.1
Bone: cortical thickness	0.7	1.1	1.6	1.3	-1.3	-0.0
Bone: cortical thickness	0.4	0.5	0.8	0.9	-0.8	-0.1
Bone: cortical tissue density	2.1	2.9	4.5	-1.8	2.1	-0.9
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.2	-0.3	0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.3	0.2	-0.4
Condit. Reinf. active responses	0.1	0.2	0.5	-0.7	-0.2	0.1
Condit. Reinf. inactive responses	0.2	0.3	0.7	-0.1	-0.8	0.2
Incentive salience index mean	0.5	0.6	1.3	-0.7	0.2	-1.1
Condit. Reinf. lever presses	1.4	1.9	3.5	-1.3	0.8	-1.9
Condit. Reinf. active minus inactive responses	1.5	2.0	3.4	1.2	-1.1	1.8
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	0.4	-0.4	0.6
Condit. Reinf. active responses	1.4	2.0	3.0	1.1	-1.3	1.7
Condit. Reinf. inactive responses	0.3	0.4	0.8	0.5	-0.9	0.5
Condit. Reinf. lever presses	1.4	1.9	3.2	1.5	-1.8	0.6
Condit. Reinf. lever reinforcers received	0.9	1.3	2.2	0.8	-0.9	1.5
Conditioned reinforcement - actives	2.0	3.5	6.0	-2.4	1.3	-1.7
Conditioned reinforcement - inactives	0.1	0.2	0.4	-0.6	0.0	0.3
Conditioned locomotion	2.0	2.6	4.6	-2.1	0.9	-1.5
Patch foraging indifference point 0 sec	0.2	0.4	1.1	-0.2	1.1	0.3
Patch foraging indifference point AUC	0.8	1.1	1.5	1.2	-1.0	0.9
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	-0.0	-0.1	0.3
Delay disc. indifference point, 16s delay	0.4	0.4	0.8	-0.6	0.9	0.2
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	0.1	-0.2	-0.1
Delay disc. indifference point, 24s delay	0.5	0.6	1.0	-0.8	0.2	-1.0
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	0.7	-0.5	1.0
Delay disc. indifference point, 8s delay	0.7	0.8	1.2	1.1	-1.0	0.5
Indifference point function ln k	0.6	1.0	1.4	-0.9	1.0	-1.2
Indifference point function log k	0.6	1.0	1.4	-0.9	1.0	-1.2
Patch foraging total patch changes 0 sec	0.3	0.5	1.5	-0.2	1.2	0.2
Patch foraging total patch changes 12 sec	0.2	0.2	0.6	0.2	0.2	0.7
Patch foraging total patch changes 18 sec	0.4	0.7	1.6	-0.4	1.3	0.5
Patch foraging total patch changes 24 sec	0.1	0.1	0.4	-0.0	0.7	-0.0
Patch foraging total patch changes 6 sec	0.6	0.9	1.9	0.9	-0.2	1.4
Patch foraging time to switch 0 sec	0.5	1.0	1.6	-1.3	1.0	-0.5
Patch foraging water rate 0 sec	0.4	0.9	2.1	-0.7	1.4	-0.4
Patch foraging water rate 12 sec	0.9	1.9	3.8	1.9	-1.3	0.3
Patch foraging water rate 18 sec	0.2	0.3	0.8	0.9	0.2	-0.4
Patch foraging water rate 24 sec	1.1	1.6	3.4	1.8	-1.1	0.5
Patch foraging water rate 6 sec	1.6	2.3	4.5	-1.2	2.1	-1.0
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.0	-0.0	-0.7	-1.0
Distance traveled before self-admin	0.4	0.5	1.3	-1.1	0.1	-0.4
Distance traveled after self-admin	0.8	1.0	1.5	-1.1	0.2	-1.2
Extensor digitorum longus weight	0.8	3.0	4.7	2.2	-1.9	-0.9
Bone: elastic displacement	0.1	0.1	0.3	-0.1	-0.1	0.5
Bone: elastic work	0.5	0.6	0.8	0.9	-0.8	0.6
Bone: endosteal estimation	0.1	0.2	0.3	0.5	-0.3	0.5
Bone: endosteal perimeter	0.2	0.4	0.5	0.7	-0.6	0.6
Epididymis fat weight	0.3	1.0	1.9	1.4	-1.1	0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	-0.4	0.2
Delta time in open arm before/after self-admin	0.7	0.7	1.4	0.7	-0.4	1.2
Diff in mean of infusions in LGA sessions	0.2	0.3	0.5	-0.5	0.7	0.5
Delay discount exponential model param	0.0	0.0	0.1	-0.3	0.1	-0.1
Extinction: sum of active levers before priming	0.3	0.3	0.8	-0.1	-0.9	-0.3
Active lever presses in extinction session 6	0.0	0.0	0.1	0.1	-0.0	-0.3
Bone: final force	0.2	0.3	0.8	0.4	-0.9	0.1
Bone: final moment	0.3	0.5	1.1	0.7	-1.0	0.4
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.2	-0.2	-0.2
Glucose	0.2	0.3	0.5	0.4	0.7	0.4
Heart weight	0.9	1.4	2.2	1.5	-0.4	1.4
Delay discount hyperbolic model param	0.0	0.0	0.0	-0.2	0.1	-0.1
Intermittent access intake day 1-15 change	0.0	0.0	0.1	0.3	-0.2	0.0
Intermittent access intake escalation	0.0	0.1	0.1	0.4	-0.1	0.1
Intermittent access intake escalation 2	0.3	0.4	0.6	0.8	-0.6	0.4
Intermitt. access day 1 inactive lever presses	0.2	0.9	1.2	-1.1	0.8	-0.9
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.5	-0.0	-0.1	0.7
Intermitt. access escalation Index	0.3	0.4	0.8	0.4	-0.5	-0.9
Intermittent access day 1 total infusions	2.5	4.0	7.5	-2.7	1.8	-1.1
Intermittent access day 15 total infusions	1.0	1.5	3.0	-1.7	1.0	-0.7
Intermittent access terminal intake (last 3 days)	1.1	1.5	3.1	-1.7	0.7	-0.9
Intermittent access total infusions	3.2	3.7	7.1	-2.7	1.5	-1.4
Intermittent access day 1 locomotion	3.9	4.9	8.5	-2.9	2.3	-1.0
Intermittent access day 15 total locomotion	1.9	3.4	5.2	-2.3	1.7	-1.4
Intermittent access total locomotion	3.9	4.6	8.6	-2.9	2.0	-1.1
Intermittent access standard deviation	0.5	1.1	2.0	0.8	-1.4	0.8
Left kidney weight	0.6	3.0	4.6	1.6	-2.1	-1.4
Right kidney weight	1.2	5.5	9.7	2.2	-3.1	-1.3
Cocaine induced anxiety	0.1	0.1	0.3	-0.5	-0.1	-0.1
Post-drug Anxiety	0.3	0.4	0.5	-0.6	0.7	0.4
Baseline Anxiety	0.3	0.3	0.5	0.2	0.7	0.6
Tail length	0.8	3.1	5.5	-1.8	2.3	-0.7
Length with tail	0.4	1.7	2.9	-1.3	1.7	-0.6
Length without tail	0.3	0.8	1.4	-1.0	1.2	-0.3
Times rat made contact with spout	0.0	0.0	0.0	0.1	0.0	0.1
Lifetime Intake	2.9	3.6	6.2	-2.5	1.7	-1.3
Liver weight, left	1.8	3.0	8.0	-0.8	0.6	-2.8
Liver weight, right	1.1	2.0	4.1	-0.8	1.1	-2.0
Locomotor activity	0.6	1.0	1.8	0.8	-0.6	1.4
Locomotor testing distance	1.0	1.7	4.3	0.8	-0.4	2.1
Locomotor testing rearing	2.3	4.6	10.2	1.6	-1.0	3.2
Locomotion in novel chamber	2.9	3.7	5.8	-1.7	1.6	-2.4
Locomotion in novel chamber post-restriction	0.9	1.5	3.5	-0.2	1.0	1.9
Fecal boli incidents, locomotor time 1	3.0	4.3	5.1	-1.8	2.2	-2.2
Change in fecal boli incidents, locomotor task	4.1	4.0	5.8	2.1	-1.4	2.4
Time >=10cm from walls, locomotor time 1	0.7	0.8	2.3	0.2	-0.1	1.5
Bouts of movement, locomotor time 1	0.3	0.4	0.6	0.8	-0.1	-0.7
Total resting periods, locomotor time 1	0.4	0.4	0.9	0.2	0.6	-1.0
Rest time, locomotor task time 1	0.6	0.7	1.2	0.0	1.1	1.0
Distance moved, locomotor task time 1	0.2	0.3	0.4	-0.6	-0.5	-0.3
Vertical activity count, locomotor time 1	0.1	0.2	0.5	0.2	-0.7	0.4
Time >=10cm from walls, locomotor time 2	2.7	4.0	6.9	2.0	-2.6	1.0
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.1	-0.2	0.1
Total resting periods, locomotor time 2	0.0	0.0	0.0	-0.2	-0.1	0.1
Rest time, locomotor task time 2	1.2	1.5	2.9	1.0	-0.7	1.7
Distance moved, locomotor task time 2	0.3	0.4	0.9	-0.0	-1.0	-0.4
Vertical activity count, locomotor time 2	0.2	0.3	0.4	0.4	-0.6	0.5
Light reinforcement 1	0.3	0.7	1.2	0.6	-1.1	0.8
Light reinforcement 2	0.4	0.5	0.6	0.6	-0.8	-0.8
Bone: marrow area	0.1	0.1	0.2	0.5	-0.2	0.4
Bone: maximum diameter	0.4	0.7	1.1	1.0	-0.8	0.7
Bone: maximum force	0.4	0.8	1.1	1.0	-1.0	0.5
Bone: maximum moment	0.6	1.1	1.5	1.2	-1.2	0.7
Mean time between licks in bursts	0.3	0.7	0.8	-0.8	0.8	-0.9
Mean num. licks in bursts	0.3	0.5	1.0	0.3	-0.6	-1.0
Cd content in liver	2.1	2.4	3.9	-1.8	2.0	-0.4
Co content in liver	0.4	0.4	0.7	-0.8	0.6	-0.5
Cu content in liver	0.2	0.2	0.5	0.0	-0.7	-0.3
Fe content in liver	1.4	1.7	4.5	-0.7	-0.1	-2.1
K content in liver	1.2	1.1	2.8	-0.3	-0.7	-1.7
Mg content in liver	1.0	1.0	1.7	0.3	-1.1	-1.3
Mn content in liver	1.0	1.1	2.7	-0.6	-0.6	-1.7
Na content in liver	0.5	0.6	1.0	0.5	-1.0	0.7
Rb content in liver	1.2	1.4	3.2	-1.8	0.9	-0.5
Se content in liver	1.5	1.8	3.1	-1.5	0.1	-1.8
Sr content in liver	2.2	1.9	2.7	1.6	-0.8	1.5
Zn content in liver	1.5	1.6	2.9	1.4	-1.7	0.1
Bone: minimum diameter	0.4	0.8	1.5	1.2	-0.7	0.4
Time in familiar zone, hab. session 1	1.1	1.0	1.9	1.4	-0.6	0.9
Time in novel zone, hab. session 1	0.2	0.2	0.5	-0.7	0.2	-0.0
Total zone transitions, hab. session 1	3.4	4.7	5.5	1.9	-2.3	2.2
Total locomotion distance, hab. session 1	2.2	3.2	6.2	1.4	-2.5	1.1
Locomotion velocity, hab. session 1	2.1	3.0	5.6	1.4	-2.4	1.2
Time in familiar zone, hab. session 2	0.7	0.7	1.2	0.8	-1.1	0.6
Time in novel zone, hab. session 2	0.0	0.0	0.1	0.2	-0.2	-0.3
Total zone transitions, hab. session 2	3.9	5.0	6.3	2.3	-2.5	1.8
Total locomotion distance, hab. session 2	3.7	4.9	8.6	2.2	-2.9	1.1
Locomotion velocity, hab. session 2	3.5	4.7	8.0	2.1	-2.8	1.3
Novel to familiar place preference ratio	0.2	0.2	0.6	-0.8	-0.3	-0.2
Novelty place preference	0.2	0.2	0.4	-0.6	-0.4	-0.0
Time in novel zone, NPP test	0.2	0.2	0.5	-0.4	-0.7	0.2
Total zone transitions, NPP test	2.6	3.7	5.0	2.2	-2.2	1.2
Total locomotion distance, NPP test	4.6	6.3	11.2	2.7	-3.3	0.9
Locomotion velocity, NPP test	4.2	5.9	10.4	2.6	-3.2	0.8
Intraocular pressure	0.3	0.4	0.9	-0.2	1.0	0.4
Delta distance traveled before/after self-admin	0.1	0.2	0.3	0.1	0.4	-0.6
Delta ambulatory time before/after self-admin	0.4	0.5	0.8	-0.3	0.8	-0.9
Parametrial fat weight	0.1	0.3	0.8	0.1	0.3	-0.9
Pavlov. Cond. lever latency	2.3	2.8	4.7	1.4	-1.4	2.2
Pavlov. Cond. magazine entry latency	0.6	0.7	1.1	1.0	-1.0	-0.2
Pavlov. Cond. change in total contacts	3.9	4.2	4.9	-1.9	2.0	-2.2
Pavlov. Cond. index score	0.8	1.1	2.4	-0.6	0.6	-1.5
Pavlov. Cond. latency score	1.0	1.3	2.9	-0.8	0.7	-1.7
Pavlov. Cond. lever contacts	1.6	1.9	4.4	-0.8	0.8	-2.1
Pavlov. Cond. magazine entry number	0.3	0.4	1.2	0.1	-0.2	1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.5	-0.7	0.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.3	-0.7	0.8	-1.5
Pavlov. Cond. response bias	0.4	0.5	1.3	-0.1	0.2	-1.2
Pavlov. Cond. lever latency	4.3	5.9	8.1	-2.9	2.8	-1.3
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	1.1	-0.8	-0.2
Pavlov. Cond. change in total contacts	4.3	6.9	7.8	2.7	-2.3	2.8
Pavlov. Cond. index score	2.7	3.6	5.5	2.3	-2.1	1.0
Pavlov. Cond. latency score	2.6	3.5	5.5	2.3	-2.0	0.9
Pavlov. Cond. lever contacts	3.7	5.0	7.2	2.7	-2.6	1.2
Pavlov. Cond. magazine entry number	1.6	2.0	2.7	-1.6	1.4	-1.2
Pavlov. Cond. intertrial magazine entries	0.6	0.9	2.2	-0.8	-0.1	-1.5
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.4	5.5	2.3	-2.0	0.9
Pavlov. Cond. response bias	3.2	4.4	6.1	2.5	-2.3	1.3
Time in closed arm before self-admin	0.3	0.4	0.7	0.8	-0.5	0.6
Time in closed arm after self-admin	0.1	0.1	0.2	-0.2	0.2	-0.5
Time in open arm before self-admin	1.4	1.6	2.1	-1.4	0.9	-1.3
Time in open arm after self-admin	0.5	0.6	1.0	0.6	-1.0	0.6
Bone: periosteal estimation	0.3	0.7	1.1	1.1	-0.9	0.1
Bone: periosteal perimeter	1.0	1.8	2.6	1.6	-1.3	1.0
Bone: post-yield work	0.7	1.0	1.2	1.1	-1.0	1.0
Progressive ratio test 1 active lever presses	1.6	2.0	4.0	-2.0	1.2	-0.8
Progressive ratio test 1 breakpoint	1.6	2.0	3.9	-2.0	1.3	-0.7
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.5	-0.7	0.7	-0.2
Progressive ratio test 2 active lever presses	4.2	4.9	8.5	-2.9	1.7	-1.8
Progressive ratio test 2 breakpoint	4.5	5.1	8.7	-3.0	1.8	-1.8
Progressive ratio test 2 inactive lever presses	1.2	2.0	4.1	-2.0	1.0	-1.0
Incentive Sensitization - Responses	1.8	2.6	3.8	-1.9	1.2	-1.6
Incentive Sensitization - Breakpoint	2.3	2.9	4.3	-2.1	1.3	-1.7
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	0.5	-1.0	0.5
Progressive ratio	0.5	0.8	1.2	-1.1	1.0	-0.6
Food seeking constrained by brief footshock	0.7	0.9	1.3	0.9	-1.1	-0.7
Seeking ratio, punishment vs. effort	0.9	1.3	1.9	1.4	-1.4	-0.1
Retroperitoneal fat weight	0.2	0.9	1.7	1.3	-0.9	-0.2
Reaction time number correct	2.2	4.3	5.2	2.3	-1.8	2.1
Reaction time mean minus median	1.4	3.4	6.0	1.9	-2.5	0.7
Reaction time mean minus median AUC	1.5	3.8	7.3	1.9	-2.7	0.5
Reaction time num false alarms	2.1	2.9	3.4	-1.8	1.5	-1.8
Reaction time num false alarms AUC	2.4	3.8	4.2	-2.0	1.8	-2.0
Reaction time trials correct on left	2.2	4.3	5.2	2.3	-1.8	2.1
Reaction time trials on left	2.5	4.7	5.7	2.4	-1.9	2.2
Reaction time mean	0.3	0.4	1.2	-0.0	-1.1	0.2
Reaction time mean AUC	0.2	0.3	0.8	-0.4	-0.9	0.2
Median of all reaction times	0.2	0.2	0.4	-0.6	-0.5	-0.0
Reaction time omissions	3.0	4.4	5.9	2.3	-2.4	1.5
Reaction time false alarm rate	5.5	7.5	8.8	-2.8	2.4	-3.0
Reaction time premature initiation rate	1.6	2.2	3.2	1.4	-1.8	-1.2
Reaction time premature initiations	2.2	4.0	6.1	2.4	-2.5	0.1
Std. dev. reaction times	0.7	1.4	3.1	0.9	-1.7	0.4
Reaction time trials completed	2.5	4.7	5.7	2.4	-1.9	2.2
Reaction time trials AUC	2.3	4.4	5.4	2.3	-1.9	2.0
Run reversals in cocaine runway, females	0.6	0.6	1.3	0.5	-0.5	-1.1
Run reversals in cocaine runway, males	3.8	3.8	7.1	-1.9	2.7	-0.8
Latency to leave start box in cocaine runway	0.1	0.2	0.4	0.1	0.7	0.1
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	-0.2	0.7	-0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.1	0.6	-0.0
Std. dev. time between licks in bursts	0.2	0.2	0.6	-0.3	0.2	-0.8
Total sessions with >9 infusions	0.9	1.1	1.6	-1.3	0.7	-1.1
Short access day 1 total inactive lever presses	1.0	1.3	2.2	-1.2	1.5	-0.4
Short access day 10 total inactive lever presses	0.2	0.4	0.5	0.7	-0.7	0.5
Short access day 1 total infusions	2.1	2.8	3.6	-1.9	1.5	-1.7
Short access day 10 total infusions	3.4	4.4	6.4	-2.5	2.0	-1.6
Short access total infusions	3.0	3.8	5.1	-2.3	1.9	-1.6
Short access day 1 locomotion	2.7	3.3	4.5	-2.1	1.7	-1.6
Short access day 10 total locomotion	0.0	0.0	0.0	-0.0	-0.2	0.0
Short access total locomotion	1.9	2.3	3.5	-1.9	1.4	-1.2
One hour access (0.3 mA shock)	0.3	0.3	0.9	0.0	-0.9	0.2
Compulsive drug intake	1.3	1.5	2.9	1.7	-0.9	0.9
One hour access (shock baseline)	0.3	0.4	1.2	-1.1	0.1	-0.4
Social response proportion	1.0	1.2	2.4	1.0	-1.5	0.3
Social responses	4.5	5.8	8.9	2.1	-2.0	3.0
Social time	3.7	5.0	7.7	1.6	-2.2	2.8
Soleus weight	0.3	0.8	1.3	0.8	-0.8	-1.1
Bone: stiffness	0.0	0.0	0.0	-0.2	-0.1	0.0
Tibialis anterior weight	1.0	3.2	4.9	2.2	-2.1	-0.5
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.2	0.1	0.1
Time to tail flick, vehicle, after self-admin	0.7	1.0	2.0	0.3	1.0	1.4
Time to tail flick, test, before self-admin	1.7	1.7	2.3	-1.5	1.4	-1.0
Time to tail flick, test, after self-admin	0.9	1.0	1.9	-1.0	1.4	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.7	0.7	0.1	0.9
Delta time to tail flick, test, before/after SA	0.8	0.8	1.0	1.0	-0.9	0.7
Tibia length	0.5	1.2	2.9	-0.9	-0.2	-1.7
Ambulatory time before self-admin	0.9	1.4	2.9	-1.7	0.9	-0.7
Ambulatory time after self-admin	2.5	2.9	4.3	-2.1	1.5	-1.5
Bone: tissue strength	1.7	1.7	2.3	1.4	-1.5	1.0
Total heroin consumption	0.0	0.0	0.1	-0.3	-0.0	0.2
Bone: trabecular number	0.0	0.0	0.0	-0.1	0.2	-0.2
Bone: trabecular spacing	0.0	0.0	0.1	0.2	-0.2	0.0
Bone: trabecular thickness	0.7	0.9	1.2	0.9	-1.1	0.7
Bone: trabecular tissue density	0.5	0.7	1.1	-1.1	0.8	0.6
Water consumed over 24 hours	0.3	0.5	0.8	-0.1	0.9	0.7
Number of responses in last shaping day	4.6	5.0	6.9	-2.6	2.5	-1.4