Hub : Genes

Bsg

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Bsg 0.54 0.18 0.0e+00 0.27 0.27 0.28 0.27 5.2e-30 2.9e-30 1.6e-30 1.7e-30
2 Liver gene expression Bsg 0.35 0.17 0.0e+00 0.19 0.18 0.19 0.19 1.3e-20 5.2e-20 1.7e-20 2.6e-20
3 PL gene expression Bsg 0.38 0.17 0.0e+00 0.17 0.18 0.18 0.18 1.1e-18 4.0e-19 1.8e-19 3.1e-19
4 LHb gene expression Bsg 0.22 0.15 5.8e-04 0.08 0.09 0.11 0.08 5.8e-03 3.3e-03 1.4e-03 6.2e-03
5 Brain gene expression Bsg 0.41 0.13 0.0e+00 0.18 0.21 0.21 0.21 5.8e-17 3.5e-19 1.4e-19 2.0e-19
6 BLA gene expression Bsg 0.34 0.17 1.2e-06 0.12 0.1 0.11 0.11 3.2e-07 6.1e-06 1.3e-06 1.2e-06
7 NAcc gene expression Bsg 0.34 0.15 6.7e-16 0.12 0.14 0.14 0.14 3.4e-14 2.5e-16 3.2e-16 3.6e-16
8 IL gene expression Bsg 0.38 0.21 1.2e-04 0.12 0.09 0.1 0.1 1.0e-03 3.9e-03 2.2e-03 2.1e-03
9 OFC gene expression Bsg 0.39 0.21 1.5e-04 0.18 0.15 0.16 0.16 4.6e-05 1.9e-04 1.3e-04 1.0e-04
10 pVTA gene expression Bsg 0.33 0.16 3.4e-07 0.17 0.14 0.14 0.15 1.1e-07 1.1e-06 8.0e-07 3.6e-07
11 Brain mRNA stability Bsg 0.05 0.04 7.6e-06 0.04 0.05 0.04 0.04 2.9e-04 3.1e-05 2.1e-04 1.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.81.44.0-1.2-0.9-1.4-0.9-1.5-1.02.0-0.9-0.9-0.90.5
Area under the delay curve2.12.22.81.61.71.41.61.21.4-1.01.61.61.61.6
BMI with tail6.621.325.04.64.74.54.84.35.0-3.84.74.74.74.8
BMI without tail3.67.58.22.82.72.82.82.72.7-2.82.92.92.92.1
Body weight1.35.36.02.22.32.22.42.22.5-2.02.42.42.42.3
Weight adjusted by age1.51.72.71.41.31.41.31.41.2-1.71.21.21.20.7
Bone surface2.64.510.0-2.2-1.9-2.4-1.9-2.8-1.93.2-1.9-1.9-1.9-0.1
Bone volume2.34.09.2-2.1-1.7-2.3-1.8-2.6-1.83.0-1.7-1.7-1.70.0
Breakpoint value in progressive ratio session3.74.16.6-1.9-2.1-1.8-2.2-1.6-2.11.2-2.1-2.1-2.1-2.6
Number of licking bursts0.70.81.81.00.81.10.81.00.9-1.30.70.70.70.1
Context. condit. distance diff. score0.20.20.40.40.30.40.50.40.1-0.60.70.70.70.2
Locomotion velocity, session 11.51.62.6-1.2-1.2-1.3-1.3-1.5-1.11.6-1.3-1.3-1.3-0.6
Locomotion distance, session 12.63.36.4-2.1-1.9-2.1-1.6-2.3-1.72.5-1.4-1.4-1.4-0.6
Locomotion velocity, session 28.710.212.1-3.5-3.4-3.5-3.2-3.5-3.23.4-3.0-3.0-3.0-2.5
Locomotion distance, session 24.86.710.4-2.8-2.5-2.8-2.5-2.9-2.33.2-2.5-2.5-2.5-1.3
Locomotion velocity, session 35.36.19.5-2.4-2.7-2.3-2.6-2.0-2.61.5-2.5-2.5-2.5-3.1
Locomotion distance, session 30.00.00.20.1-0.10.20.10.40.2-0.40.20.20.2-0.2
Stereotopy head waving bouts, day 36.78.08.8-3.0-3.0-2.8-2.9-2.8-2.82.4-2.8-2.8-2.8-2.9
Stereotopy head waving duration, day 36.78.09.1-2.8-2.9-2.7-2.9-2.7-2.92.2-2.9-2.9-2.9-3.0
Locomotion velocity, session 70.50.51.4-0.8-1.0-0.6-0.6-0.5-0.90.2-0.4-0.4-0.4-1.2
Locomotion distance, session 70.70.91.80.90.71.00.91.10.7-1.31.01.01.00.2
Stereotopy head waving bouts, day 70.60.71.2-1.0-0.9-1.0-0.7-1.0-0.71.1-0.7-0.7-0.7-0.3
Stereotopy head waving duration, day 71.11.42.2-1.2-1.2-1.3-1.1-1.4-1.11.5-1.1-1.1-1.1-0.5
Locomotion velocity, session 82.83.35.0-2.1-2.0-2.0-1.7-2.2-1.92.1-1.6-1.6-1.6-1.1
Locomotion distance, session 80.91.31.7-1.2-1.3-1.3-1.0-1.3-1.31.3-0.9-0.9-0.9-0.7
Degree of sensitization distance0.30.30.50.50.50.60.60.30.5-0.40.70.70.70.5
Degree of sensitization stereotypy0.80.92.20.70.90.71.00.71.0-0.31.01.01.01.5
Conditioned locomotion3.03.54.81.81.71.91.92.21.9-2.01.91.91.91.2
Cocaine response after cond. corrected9.710.912.73.63.43.63.43.33.2-3.43.33.33.32.6
Cocaine response after cond. not corrected10.211.312.83.53.43.63.43.53.2-3.53.43.43.42.6
Cocaine response before conditioning0.70.81.2-1.1-1.1-1.0-0.9-0.5-0.90.7-0.8-0.8-0.8-1.0
Saline control response0.10.10.40.30.30.30.30.60.5-0.40.30.30.30.3
Bone: connectivity density0.30.51.8-0.6-0.4-0.8-0.4-1.0-0.51.4-0.3-0.3-0.30.7
Bone: cortical apparent density1.11.42.21.41.51.31.20.81.4-0.91.01.01.01.4
Bone: cortical area0.20.20.90.20.40.20.50.00.50.10.60.60.60.9
Bone: cortical porosity1.01.11.4-1.2-1.1-1.2-1.0-0.9-1.11.2-1.0-1.0-1.0-0.6
Bone: cortical porosity0.70.71.5-1.0-0.9-1.1-0.7-0.9-0.81.2-0.7-0.7-0.7-0.1
Bone: cortical thickness0.61.12.20.81.00.81.10.81.1-0.51.11.11.11.5
Bone: cortical thickness0.60.71.60.90.80.90.71.30.7-1.20.70.70.70.1
Bone: cortical tissue density0.81.11.81.31.31.21.00.71.2-0.80.80.80.81.2
Condit. Reinf. active minus inactive responses4.55.16.4-2.3-2.4-2.2-2.4-1.9-2.41.7-2.3-2.3-2.3-2.5
Condit. Reinf. active-inactive response ratio1.01.12.3-0.8-1.0-0.9-1.2-0.5-1.10.4-1.2-1.2-1.2-1.5
Condit. Reinf. active responses6.07.48.6-2.9-2.9-2.9-2.8-2.6-2.82.6-2.6-2.6-2.6-2.4
Condit. Reinf. inactive responses3.13.75.3-2.2-2.0-2.2-1.8-2.1-1.92.3-1.7-1.7-1.7-1.1
Incentive salience index mean4.14.96.0-2.4-2.4-2.4-2.3-2.1-2.32.1-2.1-2.1-2.1-2.0
Condit. Reinf. lever presses1.52.04.5-1.7-1.4-1.7-1.2-1.8-1.32.1-1.1-1.1-1.1-0.2
Condit. Reinf. active minus inactive responses0.60.72.1-0.6-0.8-0.5-0.9-0.1-0.7-0.1-1.0-1.0-1.0-1.4
Condit. Reinf. active-inactive response ratio0.50.61.31.00.80.90.61.10.7-1.10.30.30.30.2
Condit. Reinf. active responses0.71.02.5-0.9-1.0-0.8-1.1-0.4-0.90.3-1.2-1.2-1.2-1.6
Condit. Reinf. inactive responses0.70.81.9-0.9-1.0-0.8-0.9-0.6-0.90.5-0.9-0.9-0.9-1.4
Condit. Reinf. lever presses0.91.22.8-1.0-1.2-0.9-1.2-0.3-1.10.4-1.2-1.2-1.2-1.7
Condit. Reinf. lever reinforcers received0.30.51.7-0.4-0.6-0.3-0.70.0-0.5-0.2-0.8-0.8-0.8-1.3
Conditioned reinforcement - actives2.02.02.5-1.5-1.6-1.4-1.5-1.2-1.51.2-1.4-1.4-1.4-1.4
Conditioned reinforcement - inactives0.70.81.10.80.80.90.91.00.8-0.81.11.11.10.6
Conditioned locomotion6.47.69.0-2.8-3.0-2.7-2.9-2.5-2.92.3-2.8-2.8-2.8-2.9
Patch foraging indifference point 0 sec0.10.10.30.20.30.20.30.20.5-0.10.30.30.30.6
Patch foraging indifference point AUC0.50.60.7-0.7-0.7-0.7-0.8-0.5-0.70.5-0.9-0.9-0.9-0.9
Delay disc. indifference point, 0s delay2.42.68.51.31.71.01.70.51.7-0.01.71.71.72.9
Delay disc. indifference point, 16s delay0.10.10.30.50.50.40.40.10.3-0.20.30.30.30.4
Delay disc. indifference point, 2s delay3.63.96.51.82.11.72.11.62.2-1.12.12.12.12.5
Delay disc. indifference point, 24s delay1.31.21.61.31.31.21.20.91.2-1.01.11.11.11.0
Delay disc. indifference point, 4s delay0.50.50.90.70.80.60.80.40.7-0.20.80.80.81.0
Delay disc. indifference point, 8s delay2.22.32.61.61.61.51.61.51.2-1.41.61.61.61.2
Indifference point function ln k0.40.60.70.80.80.80.80.80.8-0.80.80.80.80.6
Indifference point function log k0.40.60.70.80.80.80.80.80.8-0.80.80.80.80.6
Patch foraging total patch changes 0 sec0.10.10.20.20.30.30.30.30.5-0.20.30.30.30.5
Patch foraging total patch changes 12 sec0.60.81.00.80.80.90.91.00.9-0.90.90.90.90.7
Patch foraging total patch changes 18 sec0.91.21.4-1.1-1.1-1.1-1.2-0.7-1.10.8-1.2-1.2-1.2-1.2
Patch foraging total patch changes 24 sec0.10.10.2-0.2-0.2-0.3-0.3-0.2-0.20.4-0.4-0.4-0.4-0.1
Patch foraging total patch changes 6 sec0.20.30.5-0.5-0.4-0.5-0.6-0.5-0.40.5-0.7-0.7-0.7-0.3
Patch foraging time to switch 0 sec0.20.31.1-0.4-0.1-0.40.1-0.9-0.21.00.20.20.21.1
Patch foraging water rate 0 sec1.21.94.31.41.11.51.22.01.2-2.11.11.11.1-0.0
Patch foraging water rate 12 sec3.75.67.52.62.42.62.32.72.4-2.72.22.22.21.3
Patch foraging water rate 18 sec2.12.87.01.81.41.91.42.31.5-2.71.41.41.4-0.2
Patch foraging water rate 24 sec3.65.09.22.32.12.42.03.02.1-3.02.02.02.00.6
Patch foraging water rate 6 sec0.60.82.41.00.71.10.61.30.7-1.60.60.60.6-0.5
Seeking ratio, delayed vs. immediate footshock4.35.05.8-2.2-2.2-2.1-2.4-2.1-2.21.9-2.4-2.4-2.4-2.3
Distance traveled before self-admin0.30.30.80.50.70.40.50.10.5-0.20.50.50.50.9
Distance traveled after self-admin0.70.70.9-0.8-0.8-0.9-0.9-1.0-0.90.8-0.9-0.9-0.9-0.7
Extensor digitorum longus weight5.321.024.24.54.54.54.84.44.6-4.34.94.94.94.1
Bone: elastic displacement0.10.10.2-0.2-0.2-0.3-0.3-0.1-0.40.4-0.5-0.5-0.5-0.1
Bone: elastic work0.30.30.70.70.70.50.60.70.4-0.40.50.50.50.8
Bone: endosteal estimation0.10.20.30.40.40.40.50.20.5-0.40.40.40.40.4
Bone: endosteal perimeter0.51.11.6-1.1-1.1-1.1-1.0-1.3-1.01.1-0.9-0.9-0.9-0.8
Epididymis fat weight0.20.40.7-0.6-0.7-0.6-0.7-0.5-0.70.3-0.7-0.7-0.7-0.8
Delta time in closed arm before/after self-admin3.93.86.12.11.92.21.82.41.9-2.51.81.81.80.9
Delta time in open arm before/after self-admin0.60.61.50.70.80.60.80.30.8-0.30.80.80.81.2
Diff in mean of infusions in LGA sessions1.92.12.5-1.4-1.5-1.4-1.5-1.4-1.51.1-1.5-1.5-1.5-1.6
Delay discount exponential model param2.12.22.7-1.6-1.6-1.4-1.6-1.2-1.41.1-1.6-1.6-1.6-1.6
Extinction: sum of active levers before priming0.50.51.4-0.6-0.8-0.5-0.7-0.2-0.80.2-0.6-0.6-0.6-1.2
Active lever presses in extinction session 62.52.42.7-1.5-1.5-1.5-1.6-1.5-1.61.4-1.6-1.6-1.6-1.5
Bone: final force0.71.22.00.91.10.91.30.81.2-0.71.21.21.21.4
Bone: final moment0.61.01.60.91.00.81.10.71.0-0.61.11.11.11.3
Food consumed during 24 hour testing period1.11.32.01.41.41.31.20.81.1-1.11.01.01.00.9
Glucose1.72.53.21.71.81.61.71.41.6-1.31.51.51.51.7
Heart weight0.00.00.10.10.00.1-0.20.1-0.0-0.3-0.2-0.2-0.2-0.3
Delay discount hyperbolic model param2.72.93.4-1.7-1.8-1.6-1.8-1.4-1.61.2-1.8-1.8-1.8-1.8
Intermittent access intake day 1-15 change4.74.77.1-2.2-2.4-2.1-2.3-1.7-2.31.3-2.2-2.2-2.2-2.7
Intermittent access intake escalation2.92.96.5-1.6-1.9-1.5-1.8-1.0-1.90.6-1.7-1.7-1.7-2.6
Intermittent access intake escalation 23.73.77.6-1.8-2.2-1.7-2.1-1.2-2.10.7-2.0-2.0-2.0-2.8
Intermitt. access day 1 inactive lever presses0.10.10.30.30.20.30.20.40.1-0.60.30.30.3-0.3
Intermitt. access day 15 inactive lever presses0.20.30.7-0.5-0.6-0.5-0.5-0.3-0.60.3-0.5-0.5-0.5-0.8
Intermitt. access escalation Index0.10.10.2-0.10.0-0.2-0.1-0.20.00.5-0.1-0.1-0.10.4
Intermittent access day 1 total infusions0.00.00.10.00.10.00.10.00.00.30.20.20.20.2
Intermittent access day 15 total infusions1.01.22.4-1.1-1.2-1.0-1.1-0.7-1.20.6-1.0-1.0-1.0-1.5
Intermittent access terminal intake (last 3 days)0.70.81.2-1.0-1.1-1.0-0.9-0.7-1.10.8-0.8-0.8-0.8-1.1
Intermittent access total infusions0.10.10.2-0.3-0.4-0.3-0.3-0.1-0.40.3-0.2-0.2-0.2-0.5
Intermittent access day 1 locomotion0.30.30.5-0.5-0.6-0.5-0.5-0.3-0.60.4-0.5-0.5-0.5-0.7
Intermittent access day 15 total locomotion3.03.34.4-1.8-1.9-1.8-1.9-1.4-2.01.4-1.8-1.8-1.8-2.1
Intermittent access total locomotion1.01.11.3-1.1-1.1-1.1-1.1-0.8-1.21.0-1.0-1.0-1.0-1.1
Intermittent access standard deviation1.21.32.9-1.1-1.3-1.0-1.2-0.7-1.20.5-1.2-1.2-1.2-1.7
Left kidney weight0.10.20.3-0.5-0.3-0.4-0.5-0.5-0.30.5-0.4-0.4-0.4-0.2
Right kidney weight1.13.13.9-1.7-1.8-1.6-1.9-1.6-1.81.2-1.9-1.9-1.9-2.0
Cocaine induced anxiety1.51.82.8-1.4-1.3-1.5-1.3-1.5-1.31.7-1.3-1.3-1.3-0.7
Post-drug Anxiety1.61.72.7-1.4-1.3-1.4-1.3-1.5-1.31.6-1.3-1.3-1.3-0.7
Baseline Anxiety0.10.10.30.20.00.2-0.00.30.0-0.50.00.00.0-0.5
Tail length2.26.811.1-2.5-2.8-2.4-2.7-2.2-2.91.7-2.6-2.6-2.6-3.3
Length with tail1.96.88.1-2.7-2.7-2.6-2.7-2.3-2.92.2-2.6-2.6-2.6-2.7
Length without tail0.40.81.6-1.1-0.9-1.1-0.9-0.9-0.81.2-0.8-0.8-0.8-0.3
Times rat made contact with spout0.91.01.71.21.11.31.00.80.9-1.30.90.90.90.4
Lifetime Intake0.10.10.1-0.3-0.3-0.3-0.2-0.2-0.30.3-0.1-0.1-0.1-0.3
Liver weight, left2.23.43.91.81.91.81.91.81.9-1.52.02.02.01.8
Liver weight, right0.91.52.21.01.21.11.30.91.3-0.81.41.41.41.5
Locomotor activity4.47.18.1-2.7-2.6-2.8-2.7-2.9-2.82.7-2.6-2.6-2.6-2.2
Locomotor testing distance2.33.84.3-2.0-2.0-2.1-2.0-2.0-2.11.9-2.0-2.0-2.0-1.6
Locomotor testing rearing0.10.20.40.40.30.40.30.60.4-0.60.30.30.3-0.1
Locomotion in novel chamber0.10.10.20.20.10.3-0.00.10.1-0.5-0.3-0.3-0.3-0.3
Locomotion in novel chamber post-restriction0.40.51.5-0.6-0.8-0.5-0.7-0.4-0.80.1-0.7-0.7-0.7-1.2
Fecal boli incidents, locomotor time 11.82.02.51.41.41.31.51.31.2-1.21.61.61.61.3
Change in fecal boli incidents, locomotor task0.20.10.2-0.4-0.4-0.4-0.4-0.5-0.30.4-0.4-0.4-0.4-0.3
Time >=10cm from walls, locomotor time 10.20.21.10.30.50.10.4-0.30.30.30.40.40.41.0
Bouts of movement, locomotor time 10.10.10.5-0.2-0.3-0.2-0.2-0.3-0.40.0-0.2-0.2-0.2-0.7
Total resting periods, locomotor time 10.20.20.6-0.4-0.5-0.4-0.4-0.5-0.60.2-0.4-0.4-0.4-0.8
Rest time, locomotor task time 10.70.81.2-1.0-1.0-0.9-0.8-1.1-1.10.7-0.7-0.7-0.7-1.0
Distance moved, locomotor task time 10.20.31.40.40.60.20.4-0.00.50.30.30.30.31.2
Vertical activity count, locomotor time 11.11.11.71.31.21.21.01.21.1-1.10.90.90.90.9
Time >=10cm from walls, locomotor time 22.42.52.81.61.61.61.71.41.5-1.51.71.71.71.4
Bouts of movement, locomotor time 21.61.83.0-1.3-1.2-1.4-1.3-1.7-1.21.6-1.3-1.3-1.3-0.7
Total resting periods, locomotor time 21.61.73.0-1.3-1.2-1.4-1.3-1.7-1.21.6-1.3-1.3-1.3-0.7
Rest time, locomotor task time 21.11.22.2-1.1-1.0-1.1-1.1-1.5-1.11.2-1.1-1.1-1.1-0.9
Distance moved, locomotor task time 21.01.11.61.01.01.01.11.31.1-1.01.11.11.10.9
Vertical activity count, locomotor time 21.82.03.21.41.31.41.41.81.2-1.61.51.51.50.9
Light reinforcement 17.313.314.7-3.6-3.7-3.7-3.8-3.4-3.83.4-3.7-3.7-3.7-3.4
Light reinforcement 22.93.84.2-2.0-2.1-2.0-2.0-1.9-1.92.0-2.0-2.0-2.0-1.6
Bone: marrow area0.10.20.30.40.40.40.50.20.5-0.40.40.40.40.4
Bone: maximum diameter1.42.53.4-1.7-1.6-1.7-1.6-1.8-1.61.7-1.5-1.5-1.5-1.2
Bone: maximum force1.01.72.11.21.31.21.41.11.3-1.01.41.41.41.4
Bone: maximum moment0.81.31.71.11.21.01.31.01.2-0.91.21.21.21.3
Mean time between licks in bursts2.94.16.2-2.0-2.2-1.8-2.2-1.5-1.91.2-2.2-2.2-2.2-2.5
Mean num. licks in bursts0.00.00.10.00.1-0.1-0.0-0.2-0.20.2-0.0-0.0-0.00.2
Cd content in liver0.20.20.40.40.50.30.50.60.6-0.20.40.40.40.6
Co content in liver0.40.40.9-0.8-0.9-0.7-0.7-0.3-0.70.4-0.6-0.6-0.6-0.9
Cu content in liver0.10.20.6-0.4-0.3-0.5-0.2-0.6-0.30.8-0.1-0.1-0.10.2
Fe content in liver0.10.10.3-0.5-0.6-0.3-0.10.3-0.4-0.20.10.10.1-0.5
K content in liver0.80.81.6-1.3-1.1-1.1-0.7-1.1-0.81.1-0.5-0.5-0.5-0.3
Mg content in liver0.60.61.2-1.0-0.9-1.0-0.6-1.0-0.71.1-0.5-0.5-0.5-0.1
Mn content in liver4.14.66.4-2.5-2.3-2.4-2.0-2.5-2.22.5-1.8-1.8-1.8-1.2
Na content in liver0.20.20.4-0.6-0.4-0.40.2-0.4-0.00.60.40.40.40.6
Rb content in liver0.10.10.5-0.3-0.1-0.4-0.0-0.6-0.10.70.00.00.00.6
Se content in liver0.60.71.2-1.0-1.1-1.0-0.8-0.7-1.10.7-0.6-0.6-0.6-0.9
Sr content in liver0.30.30.70.50.40.60.40.70.4-0.90.40.40.4-0.1
Zn content in liver0.30.31.7-0.0-0.30.1-0.50.4-0.2-0.6-0.5-0.5-0.5-1.3
Bone: minimum diameter0.00.10.2-0.4-0.4-0.3-0.2-0.4-0.20.3-0.1-0.1-0.1-0.2
Time in familiar zone, hab. session 11.11.02.2-0.8-1.0-0.8-1.1-0.6-1.30.4-1.1-1.1-1.1-1.5
Time in novel zone, hab. session 10.40.31.20.40.60.30.60.20.70.10.60.60.61.1
Total zone transitions, hab. session 12.83.95.4-2.2-2.0-2.1-2.0-2.2-1.72.3-1.9-1.9-1.9-1.2
Total locomotion distance, hab. session 14.15.78.2-2.8-2.6-2.7-2.3-2.7-2.32.9-2.1-2.1-2.1-1.5
Locomotion velocity, hab. session 14.76.79.1-3.0-2.8-2.8-2.5-2.9-2.52.9-2.3-2.3-2.3-1.8
Time in familiar zone, hab. session 23.43.56.7-1.5-1.7-1.6-2.0-1.1-2.20.9-2.1-2.1-2.1-2.6
Time in novel zone, hab. session 22.92.95.21.71.91.51.80.81.9-0.81.81.81.82.3
Total zone transitions, hab. session 21.11.54.3-1.1-0.8-1.3-0.9-2.1-0.72.1-0.9-0.9-0.90.3
Total locomotion distance, hab. session 23.34.47.5-2.0-1.9-2.2-2.0-2.7-1.92.6-2.0-2.0-2.0-1.2
Locomotion velocity, hab. session 23.95.39.6-2.2-2.0-2.4-2.2-3.1-2.12.9-2.2-2.2-2.2-1.2
Novel to familiar place preference ratio1.91.95.11.11.41.01.50.71.5-0.31.51.51.52.2
Novelty place preference1.01.03.00.81.00.61.10.31.0-0.01.01.01.01.7
Time in novel zone, NPP test1.21.33.30.91.20.81.20.51.2-0.31.21.21.21.8
Total zone transitions, NPP test0.81.23.0-1.2-0.9-1.2-1.0-1.5-0.71.7-1.0-1.0-1.00.0
Total locomotion distance, NPP test0.81.22.8-1.3-1.1-1.3-0.9-1.5-0.71.7-0.8-0.8-0.8-0.1
Locomotion velocity, NPP test1.21.73.5-1.5-1.2-1.5-1.2-1.7-1.01.9-1.1-1.1-1.1-0.3
Intraocular pressure0.81.12.41.31.11.30.81.60.8-1.50.70.70.70.2
Delta distance traveled before/after self-admin1.81.92.5-1.5-1.6-1.4-1.4-1.1-1.51.1-1.4-1.4-1.4-1.6
Delta ambulatory time before/after self-admin2.22.43.0-1.6-1.7-1.6-1.6-1.3-1.61.3-1.5-1.5-1.5-1.6
Parametrial fat weight0.10.30.8-0.3-0.5-0.4-0.5-0.0-0.70.1-0.5-0.5-0.5-0.9
Pavlov. Cond. lever latency0.70.91.71.31.11.20.71.21.0-1.30.50.50.50.4
Pavlov. Cond. magazine entry latency3.54.56.3-2.2-2.4-2.0-2.2-1.9-2.31.5-2.0-2.0-2.0-2.5
Pavlov. Cond. change in total contacts0.50.50.8-0.9-0.9-0.8-0.6-0.8-0.80.6-0.4-0.4-0.4-0.7
Pavlov. Cond. index score1.72.13.3-1.8-1.7-1.6-1.4-1.6-1.61.4-1.1-1.1-1.1-1.3
Pavlov. Cond. latency score2.12.74.1-2.0-1.9-1.8-1.5-1.8-1.81.8-1.3-1.3-1.3-1.3
Pavlov. Cond. lever contacts1.31.52.6-1.6-1.4-1.4-1.0-1.5-1.21.6-0.8-0.8-0.8-0.6
Pavlov. Cond. magazine entry number1.41.72.31.51.51.31.31.31.4-1.01.21.21.21.4
Pavlov. Cond. intertrial magazine entries0.10.10.50.50.30.50.20.60.3-0.70.10.10.1-0.2
Pavlov. Cond. lever-magazine prob. diff.2.22.73.8-1.9-1.9-1.8-1.6-1.7-1.81.6-1.4-1.4-1.4-1.5
Pavlov. Cond. response bias1.92.33.2-1.8-1.8-1.5-1.5-1.4-1.71.2-1.3-1.3-1.3-1.7
Pavlov. Cond. lever latency0.20.30.60.60.60.50.60.00.5-0.20.60.60.60.8
Pavlov. Cond. magazine entry latency0.30.40.7-0.7-0.7-0.5-0.6-0.5-0.60.3-0.5-0.5-0.5-0.8
Pavlov. Cond. change in total contacts0.10.20.5-0.4-0.4-0.3-0.50.0-0.40.1-0.5-0.5-0.5-0.7
Pavlov. Cond. index score0.30.30.8-0.6-0.7-0.5-0.6-0.1-0.60.2-0.6-0.6-0.6-0.9
Pavlov. Cond. latency score0.30.40.7-0.7-0.7-0.5-0.7-0.3-0.60.3-0.7-0.7-0.7-0.8
Pavlov. Cond. lever contacts0.10.20.7-0.4-0.4-0.2-0.40.2-0.3-0.1-0.4-0.4-0.4-0.8
Pavlov. Cond. magazine entry number0.50.61.10.91.00.80.80.50.9-0.50.70.70.71.0
Pavlov. Cond. intertrial magazine entries0.81.11.51.11.01.21.01.11.2-1.21.01.01.00.6
Pavlov. Cond. lever-magazine prob. diff.0.40.50.9-0.8-0.8-0.6-0.7-0.3-0.70.3-0.7-0.7-0.7-0.9
Pavlov. Cond. response bias0.50.72.0-0.8-0.9-0.6-0.9-0.2-0.80.1-0.9-0.9-0.9-1.4
Time in closed arm before self-admin0.10.20.7-0.3-0.1-0.40.1-0.6-0.10.70.10.10.10.8
Time in closed arm after self-admin0.00.00.10.0-0.00.0-0.00.1-0.0-0.3-0.0-0.0-0.0-0.1
Time in open arm before self-admin0.30.30.9-0.5-0.6-0.4-0.6-0.1-0.40.3-0.6-0.6-0.6-0.9
Time in open arm after self-admin0.91.01.11.01.11.01.00.91.1-0.71.01.01.01.1
Bone: periosteal estimation0.10.10.40.10.30.10.4-0.10.30.10.30.30.30.7
Bone: periosteal perimeter0.30.51.0-0.9-0.8-0.9-0.7-1.0-0.71.0-0.5-0.5-0.5-0.3
Bone: post-yield work0.60.81.20.70.70.91.00.90.9-1.01.11.11.10.5
Progressive ratio test 1 active lever presses0.20.30.40.50.50.60.50.60.4-0.50.50.50.50.1
Progressive ratio test 1 breakpoint0.30.30.40.60.60.60.60.70.5-0.60.60.60.60.1
Progressive ratio test 1 inactive lever presses0.00.00.1-0.1-0.2-0.2-0.2-0.3-0.30.3-0.2-0.2-0.2-0.3
Progressive ratio test 2 active lever presses0.00.00.10.1-0.00.10.00.4-0.0-0.30.10.10.1-0.4
Progressive ratio test 2 breakpoint0.10.10.2-0.3-0.3-0.2-0.20.0-0.30.1-0.2-0.2-0.2-0.4
Progressive ratio test 2 inactive lever presses0.10.20.3-0.5-0.4-0.5-0.3-0.4-0.50.6-0.2-0.2-0.2-0.2
Incentive Sensitization - Responses0.00.00.20.10.00.20.10.40.0-0.40.20.20.2-0.2
Incentive Sensitization - Breakpoint0.00.00.1-0.0-0.10.0-0.00.3-0.1-0.30.10.10.1-0.3
Sum of active levers in priming session hrs 5-60.00.00.1-0.1-0.1-0.1-0.1-0.2-0.10.3-0.1-0.1-0.10.1
Progressive ratio0.10.10.20.30.20.30.40.40.2-0.50.40.40.40.2
Food seeking constrained by brief footshock0.91.11.7-1.2-1.1-1.1-1.0-1.3-1.11.2-0.9-0.9-0.9-0.9
Seeking ratio, punishment vs. effort0.60.71.2-0.9-0.8-0.8-0.8-1.1-0.81.1-0.8-0.8-0.8-0.6
Retroperitoneal fat weight0.30.91.01.01.01.01.00.81.0-1.01.01.01.00.8
Reaction time number correct2.23.25.01.91.72.01.72.01.7-2.21.71.71.70.7
Reaction time mean minus median0.20.20.8-0.5-0.6-0.3-0.6-0.2-0.4-0.0-0.5-0.5-0.5-0.9
Reaction time mean minus median AUC0.10.10.3-0.5-0.3-0.4-0.3-0.5-0.30.5-0.2-0.2-0.2-0.1
Reaction time num false alarms0.81.11.80.90.71.01.01.31.0-1.41.11.11.10.3
Reaction time num false alarms AUC1.11.52.61.10.91.21.21.51.1-1.61.31.31.30.4
Reaction time trials correct on left2.23.25.01.91.72.01.72.01.7-2.21.71.71.70.7
Reaction time trials on left2.13.14.81.91.72.01.72.01.7-2.21.71.71.70.7
Reaction time mean0.00.00.10.00.10.10.10.10.2-0.0-0.0-0.0-0.00.3
Reaction time mean AUC0.00.00.10.10.20.20.10.10.3-0.00.00.00.00.4
Median of all reaction times0.10.20.60.30.50.30.40.30.5-0.10.30.30.30.7
Reaction time omissions0.30.40.6-0.4-0.4-0.4-0.7-0.7-0.40.6-0.8-0.8-0.8-0.3
Reaction time false alarm rate0.00.10.10.0-0.00.10.20.30.2-0.20.40.40.40.2
Reaction time premature initiation rate0.30.41.0-0.4-0.5-0.3-0.7-0.1-0.50.1-0.8-0.8-0.8-1.0
Reaction time premature initiations0.20.31.20.60.40.70.11.00.4-1.10.00.00.0-0.7
Std. dev. reaction times0.00.10.1-0.2-0.2-0.1-0.30.0-0.0-0.1-0.3-0.3-0.3-0.4
Reaction time trials completed2.13.14.81.91.72.01.72.01.7-2.21.71.71.70.7
Reaction time trials AUC2.43.55.72.01.82.11.82.11.8-2.41.81.81.80.7
Run reversals in cocaine runway, females0.50.50.6-0.7-0.7-0.7-0.7-0.7-0.80.6-0.7-0.7-0.7-0.8
Run reversals in cocaine runway, males2.01.92.2-1.4-1.4-1.4-1.5-1.3-1.51.3-1.5-1.5-1.5-1.3
Latency to leave start box in cocaine runway1.51.62.3-1.3-1.2-1.4-1.2-1.2-1.11.5-1.4-1.4-1.4-0.4
Latency to leave start box in cocaine runway, F0.50.62.0-0.7-0.4-0.9-0.5-0.7-0.31.4-0.7-0.7-0.70.7
Latency to leave start box in cocaine runway, M1.01.03.0-0.9-1.1-0.7-1.0-0.5-1.0-0.0-1.0-1.0-1.0-1.7
Std. dev. time between licks in bursts0.70.81.0-1.0-1.0-0.9-1.0-0.9-0.70.8-1.0-1.0-1.0-0.9
Total sessions with >9 infusions0.00.00.1-0.1-0.1-0.2-0.0-0.3-0.10.40.00.00.00.2
Short access day 1 total inactive lever presses0.20.20.4-0.4-0.4-0.4-0.4-0.7-0.50.5-0.3-0.3-0.3-0.4
Short access day 10 total inactive lever presses0.00.00.00.20.20.20.2-0.00.1-0.20.20.20.20.0
Short access day 1 total infusions0.80.91.4-1.0-0.9-1.1-0.9-1.2-1.01.2-0.8-0.8-0.8-0.5
Short access day 10 total infusions0.00.00.10.10.00.20.10.20.0-0.20.20.20.2-0.3
Short access total infusions0.00.00.1-0.2-0.2-0.2-0.1-0.2-0.20.3-0.0-0.0-0.0-0.0
Short access day 1 locomotion1.51.61.9-1.3-1.3-1.3-1.3-1.3-1.41.3-1.2-1.2-1.2-1.1
Short access day 10 total locomotion2.32.64.4-1.6-1.8-1.4-1.7-1.1-1.70.9-1.7-1.7-1.7-2.1
Short access total locomotion0.80.91.1-1.0-1.0-1.0-1.0-0.9-1.00.9-0.9-0.9-0.9-0.9
One hour access (0.3 mA shock)0.10.20.30.30.30.30.40.60.4-0.20.50.50.50.3
Compulsive drug intake0.60.61.60.70.80.60.80.30.9-0.20.80.80.81.3
One hour access (shock baseline)0.10.10.50.1-0.00.20.10.70.1-0.40.20.20.2-0.4
Social response proportion1.51.62.0-1.3-1.2-1.2-1.3-1.4-1.11.3-1.4-1.4-1.4-0.8
Social responses7.49.610.3-3.2-3.2-3.1-3.2-2.8-3.22.7-3.2-3.2-3.2-3.0
Social time0.20.30.90.50.60.40.60.50.6-0.10.50.50.51.0
Soleus weight8.625.128.34.95.24.85.34.65.1-4.05.35.35.35.3
Bone: stiffness1.93.03.91.51.61.61.91.31.9-1.32.02.02.01.9
Tibialis anterior weight1.03.44.31.61.71.72.01.71.8-1.62.12.12.11.8
Time to tail flick, vehicle, before self-admin1.31.42.4-1.2-1.0-1.2-1.1-1.5-1.11.5-1.1-1.1-1.1-0.6
Time to tail flick, vehicle, after self-admin0.10.10.60.1-0.10.30.10.80.1-0.70.20.20.2-0.5
Time to tail flick, test, before self-admin0.80.81.6-0.9-0.8-1.0-0.8-0.9-0.81.3-0.8-0.8-0.8-0.3
Time to tail flick, test, after self-admin0.60.60.8-0.8-0.8-0.8-0.8-0.9-0.80.7-0.8-0.8-0.8-0.6
Delta time to tail flick, vehicle, before/after SA1.71.73.21.21.01.31.21.71.1-1.81.31.31.30.4
Delta time to tail flick, test, before/after SA0.10.10.30.0-0.10.1-0.10.0-0.2-0.6-0.0-0.0-0.0-0.5
Tibia length0.61.62.7-1.2-1.3-1.2-1.3-1.1-1.30.9-1.3-1.3-1.3-1.6
Ambulatory time before self-admin0.30.30.80.60.60.50.50.20.6-0.30.50.50.50.9
Ambulatory time after self-admin0.40.40.5-0.7-0.6-0.7-0.7-0.7-0.70.6-0.7-0.7-0.7-0.5
Bone: tissue strength1.11.12.11.01.10.91.10.81.0-0.61.11.11.11.4
Total heroin consumption1.92.22.5-1.5-1.5-1.5-1.6-1.3-1.51.3-1.6-1.6-1.6-1.5
Bone: trabecular number1.92.94.4-1.9-1.7-1.9-1.7-1.9-1.82.1-1.5-1.5-1.5-0.9
Bone: trabecular spacing3.14.17.52.21.92.31.92.41.9-2.71.81.81.80.6
Bone: trabecular thickness2.12.57.1-1.6-1.2-1.8-1.3-2.2-1.32.7-1.3-1.3-1.30.5
Bone: trabecular tissue density1.92.63.31.51.61.71.71.61.8-1.61.71.71.71.3
Water consumed over 24 hours0.30.30.70.60.70.50.7-0.10.6-0.20.60.60.60.9
Number of responses in last shaping day0.10.10.2-0.4-0.4-0.4-0.3-0.3-0.40.4-0.2-0.2-0.2-0.3