Hub : Genes

Brms1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Brms1 0.07 0.04 1.7e-05 0.04 0.04 0.04 0.04 5.7e-05 5.3e-05 1.7e-04 9.1e-05
2 Liver mRNA stability Brms1 0.06 0.04 1.4e-06 0.05 0.04 0.04 0.05 2.8e-06 2.1e-05 2.1e-05 6.8e-06
3 Adipose alternative TSS NM_001009605.1 0.03 0.02 4.9e-03 0 0.01 0.01 0 8.4e-02 2.2e-02 4.3e-02 8.5e-02
4 Adipose alternative TSS XM_063286834.1 0.04 0.02 6.5e-04 0.01 0.02 0.01 0.01 2.2e-02 6.6e-03 2.7e-02 3.9e-02
5 Adipose alternative TSS XM_063286834.1 0.02 0.02 6.4e-03 0 0.01 0 0 1.4e-01 2.2e-02 8.6e-02 1.2e-01
6 PL mRNA stability Brms1 0.03 0.02 5.4e-03 0.03 0.01 0.02 0.03 2.2e-04 9.2e-03 2.5e-03 7.1e-04
7 Adipose alternative TSS NM_001009605.1 0.03 0.02 2.8e-03 0 0.01 0 0 7.5e-02 1.5e-02 1.5e-01 1.4e-01
8 IL mRNA stability Brms1 0.26 0.18 3.0e-03 0.12 0.06 0.08 0.09 7.4e-04 1.4e-02 6.9e-03 3.2e-03
9 IC gene expression Brms1 0.12 0.09 5.3e-04 0.1 0.08 0.09 0.09 6.0e-05 2.3e-04 1.7e-04 9.6e-05
10 NAcc gene expression Brms1 0.12 0.07 2.7e-12 0.08 0.09 0.09 0.08 1.1e-12 6.0e-13 5.3e-13 1.2e-12
11 pVTA gene expression Brms1 0.05 0.03 6.5e-04 0.03 0.04 0.03 0.03 1.4e-03 2.3e-04 1.2e-03 9.8e-04
12 Brain gene expression Brms1 0.47 0.18 6.3e-06 0.07 0.06 0.07 0.07 9.0e-07 1.3e-06 1.6e-07 5.6e-07
13 PL gene expression Brms1 0.04 0.04 1.8e-03 0.01 0.02 0.02 0.01 1.7e-02 6.5e-03 4.1e-03 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.91.57.30.90.90.2-0.1-0.10.6-0.10.7-1.3-2.7-1.5-1.5-1.8
Area under the delay curve0.40.51.6-0.2-0.2-0.60.60.70.2-0.70.4-1.3-1.0-1.0-0.3-0.9
BMI with tail1.34.519.32.52.51.2-1.2-1.12.20.82.4-1.1-4.4-1.6-1.5-2.3
BMI without tail0.72.06.61.71.80.9-0.9-0.82.10.62.2-0.3-2.6-0.8-0.3-0.9
Body weight1.98.215.13.73.83.1-3.1-3.03.82.83.91.5-2.91.01.20.4
Weight adjusted by age1.42.13.01.61.41.7-1.7-1.71.71.71.51.5-0.41.31.10.9
Bone surface2.64.714.23.02.92.3-2.2-2.22.11.92.2-0.3-3.8-0.2-0.7-1.3
Bone volume1.12.09.31.71.61.1-1.0-1.01.00.81.0-0.9-3.1-0.8-1.2-1.7
Breakpoint value in progressive ratio session2.42.95.02.22.22.1-2.1-2.11.72.01.70.9-1.61.00.50.3
Number of licking bursts0.20.30.60.80.70.7-0.7-0.70.50.60.50.0-0.70.20.2-0.2
Context. condit. distance diff. score1.61.93.0-1.7-1.7-1.71.61.7-1.5-1.6-1.5-0.71.1-1.0-0.8-0.3
Locomotion velocity, session 10.20.31.7-0.10.10.1-0.1-0.10.40.20.50.60.70.61.30.3
Locomotion distance, session 10.50.62.50.70.90.2-0.2-0.11.00.11.0-0.8-1.6-0.8-0.1-0.8
Locomotion velocity, session 21.92.24.11.91.91.6-1.6-1.52.01.52.00.8-1.20.71.00.2
Locomotion distance, session 20.50.82.31.01.10.6-0.6-0.51.40.51.5-0.2-1.3-0.20.5-0.3
Locomotion velocity, session 30.30.31.0-0.3-0.3-0.60.50.6-0.2-0.6-0.2-0.7-0.5-0.8-0.6-1.0
Locomotion distance, session 30.00.00.2-0.00.0-0.10.10.10.1-0.10.00.00.1-0.10.1-0.4
Stereotopy head waving bouts, day 30.91.01.8-1.0-1.1-1.31.31.4-0.6-1.3-0.5-0.90.0-1.3-0.6-1.0
Stereotopy head waving duration, day 31.31.52.2-1.2-1.2-1.41.41.5-1.1-1.5-1.0-1.2-0.1-1.4-1.1-1.0
Locomotion velocity, session 70.50.61.3-0.5-0.4-0.80.70.8-0.3-0.9-0.2-0.7-0.7-1.2-1.0-1.1
Locomotion distance, session 70.10.10.40.00.1-0.20.10.20.5-0.20.60.2-0.2-0.30.1-0.0
Stereotopy head waving bouts, day 70.70.82.8-0.1-0.2-0.30.40.4-0.8-0.5-0.8-1.0-1.0-1.0-1.6-1.7
Stereotopy head waving duration, day 70.60.72.50.90.80.6-0.5-0.50.10.30.1-0.5-1.6-0.6-1.4-1.5
Locomotion velocity, session 81.01.21.91.11.11.1-1.2-1.11.31.21.40.9-0.11.01.40.8
Locomotion distance, session 80.30.40.7-0.7-0.6-0.80.80.8-0.5-0.8-0.5-0.7-0.1-0.8-0.4-0.4
Degree of sensitization distance0.10.10.40.10.1-0.20.20.30.3-0.30.4-0.3-0.6-0.6-0.3-0.3
Degree of sensitization stereotypy0.40.51.40.70.70.6-0.5-0.6-0.20.5-0.1-0.2-1.1-0.2-1.2-1.1
Conditioned locomotion2.02.33.21.51.51.5-1.6-1.51.81.61.81.60.21.41.51.4
Cocaine response after cond. corrected0.70.91.7-1.3-1.2-1.21.11.2-0.9-1.1-1.0-0.31.1-0.5-0.20.1
Cocaine response after cond. not corrected0.60.71.2-1.1-1.0-1.01.01.0-0.9-1.0-0.9-0.60.6-0.6-0.4-0.2
Cocaine response before conditioning0.50.61.41.01.00.9-0.8-0.90.50.80.4-0.2-1.20.2-0.2-0.5
Saline control response2.83.76.42.52.12.2-2.1-2.12.52.02.50.9-1.81.01.20.4
Bone: connectivity density1.72.610.02.12.01.3-1.2-1.21.71.01.9-0.7-3.2-0.7-0.9-1.2
Bone: cortical apparent density0.30.40.80.40.40.5-0.6-0.60.50.60.40.90.70.80.70.8
Bone: cortical area0.71.11.81.21.11.3-1.3-1.30.91.30.90.9-0.41.10.70.8
Bone: cortical porosity0.10.20.70.30.30.00.00.00.5-0.10.5-0.3-0.9-0.6-0.3-0.4
Bone: cortical porosity0.30.30.80.70.60.4-0.4-0.30.90.30.90.1-0.9-0.20.0-0.1
Bone: cortical thickness4.57.59.92.62.53.0-3.1-3.02.63.12.63.20.63.02.82.6
Bone: cortical thickness1.82.24.51.00.91.2-1.3-1.31.61.41.61.91.01.72.11.5
Bone: cortical tissue density0.40.61.20.50.60.7-0.8-0.70.60.80.51.10.71.00.80.9
Condit. Reinf. active minus inactive responses0.20.20.70.60.80.4-0.4-0.40.50.30.5-0.2-0.8-0.2-0.1-0.7
Condit. Reinf. active-inactive response ratio0.10.10.30.20.50.1-0.1-0.10.10.10.1-0.3-0.5-0.2-0.3-0.6
Condit. Reinf. active responses0.10.10.50.40.70.3-0.3-0.30.40.20.4-0.2-0.6-0.2-0.1-0.3
Condit. Reinf. inactive responses0.00.00.1-0.1-0.0-0.20.10.2-0.1-0.2-0.1-0.2-0.2-0.3-0.2-0.1
Incentive salience index mean0.30.31.00.70.90.5-0.5-0.40.70.40.7-0.1-1.0-0.2-0.1-0.4
Condit. Reinf. lever presses0.30.41.00.81.00.8-0.8-0.70.60.70.60.3-0.80.30.00.3
Condit. Reinf. active minus inactive responses0.81.02.5-0.2-0.3-0.40.50.4-1.0-0.6-0.9-1.5-1.3-1.0-1.4-1.6
Condit. Reinf. active-inactive response ratio1.41.63.1-0.9-0.8-0.91.00.9-1.6-1.0-1.6-1.8-0.9-1.2-1.6-1.5
Condit. Reinf. active responses0.71.03.80.40.2-0.00.20.1-0.3-0.3-0.2-1.4-2.0-1.2-1.4-1.8
Condit. Reinf. inactive responses0.40.51.90.90.60.4-0.3-0.30.90.21.0-0.2-1.4-0.7-0.5-0.9
Condit. Reinf. lever presses1.31.84.41.91.81.6-1.5-1.51.01.41.10.1-2.10.2-0.4-0.8
Condit. Reinf. lever reinforcers received0.60.94.10.70.40.3-0.1-0.2-0.00.00.1-1.2-2.0-0.9-1.2-1.6
Conditioned reinforcement - actives0.00.10.20.0-0.10.3-0.2-0.3-0.50.3-0.4-0.10.10.4-0.1-0.0
Conditioned reinforcement - inactives1.92.75.2-1.9-1.6-1.71.81.7-2.3-1.7-2.1-1.60.6-1.2-1.5-1.2
Conditioned locomotion5.57.212.1-3.4-3.3-3.03.03.0-3.4-2.9-3.5-2.11.8-1.5-1.4-0.7
Patch foraging indifference point 0 sec0.20.41.5-0.3-0.6-0.40.40.4-0.3-0.5-0.3-1.2-0.8-0.7-0.7-0.6
Patch foraging indifference point AUC1.82.64.11.92.02.0-2.0-2.01.32.01.31.7-0.41.50.60.7
Delay disc. indifference point, 0s delay0.80.91.9-0.9-0.9-1.31.31.4-0.1-1.30.1-1.1-0.2-1.3-0.2-0.5
Delay disc. indifference point, 16s delay1.11.22.6-0.9-0.8-1.01.11.1-1.0-1.1-0.8-1.6-0.8-1.3-1.2-1.4
Delay disc. indifference point, 2s delay0.30.30.7-0.4-0.4-0.60.60.6-0.4-0.7-0.3-0.9-0.5-0.8-0.5-0.7
Delay disc. indifference point, 24s delay0.10.10.7-0.2-0.2-0.20.10.20.4-0.10.40.10.50.30.90.6
Delay disc. indifference point, 4s delay0.30.30.7-0.4-0.2-0.70.70.80.3-0.80.4-0.8-0.5-0.80.1-0.2
Delay disc. indifference point, 8s delay0.20.30.8-0.2-0.2-0.50.50.60.3-0.60.4-0.9-0.5-0.70.1-0.4
Indifference point function ln k4.47.714.5-3.7-3.8-3.53.43.4-2.7-3.3-2.7-2.02.0-1.7-0.5-0.4
Indifference point function log k4.47.714.5-3.7-3.8-3.53.43.4-2.7-3.3-2.7-2.02.0-1.7-0.5-0.4
Patch foraging total patch changes 0 sec0.00.10.3-0.2-0.5-0.10.10.10.0-0.10.0-0.6-0.2-0.10.1-0.0
Patch foraging total patch changes 12 sec3.03.97.12.72.42.4-2.4-2.32.22.22.21.4-1.61.10.50.5
Patch foraging total patch changes 18 sec0.30.51.11.01.10.8-0.7-0.70.70.70.70.1-0.90.1-0.3-0.3
Patch foraging total patch changes 24 sec1.32.23.11.71.61.8-1.8-1.81.61.81.51.2-0.31.41.10.9
Patch foraging total patch changes 6 sec0.81.22.31.51.31.3-1.2-1.21.31.11.30.4-1.20.30.0-0.4
Patch foraging time to switch 0 sec0.91.96.51.81.91.1-1.1-1.01.40.81.4-0.6-2.5-0.7-1.0-1.0
Patch foraging water rate 0 sec1.94.08.7-2.8-2.8-2.01.91.9-2.4-1.7-2.4-0.22.90.20.51.0
Patch foraging water rate 12 sec3.98.117.3-3.9-4.2-3.33.13.1-2.8-2.9-2.9-0.73.8-0.50.81.1
Patch foraging water rate 18 sec1.62.55.7-2.2-2.4-1.91.81.8-1.4-1.7-1.4-0.61.9-0.40.50.4
Patch foraging water rate 24 sec2.73.88.9-2.8-2.6-2.22.02.0-2.1-1.8-2.1-0.03.0-0.00.60.9
Patch foraging water rate 6 sec2.43.59.0-2.6-2.7-2.01.91.9-1.6-1.7-1.6-0.13.00.21.41.4
Seeking ratio, delayed vs. immediate footshock0.40.51.8-0.2-0.0-0.50.60.60.3-0.70.2-1.4-1.0-1.1-0.7-0.7
Distance traveled before self-admin0.30.41.80.70.60.5-0.4-0.50.10.40.2-0.5-1.4-0.3-0.7-0.8
Distance traveled after self-admin0.10.20.50.50.30.5-0.4-0.5-0.10.40.10.0-0.60.1-0.3-0.7
Extensor digitorum longus weight6.324.736.35.96.05.7-5.8-5.75.85.65.84.3-2.43.73.32.3
Bone: elastic displacement0.91.04.7-0.8-0.8-0.30.20.2-0.20.0-0.21.02.21.11.61.5
Bone: elastic work2.12.75.11.31.11.5-1.6-1.61.71.71.71.90.71.92.31.8
Bone: endosteal estimation1.63.55.7-1.5-1.7-1.92.02.0-1.5-2.1-1.4-2.4-1.3-2.4-1.8-1.9
Bone: endosteal perimeter2.85.911.8-1.7-1.8-2.12.22.2-2.3-2.3-2.1-3.4-2.0-2.9-2.8-3.1
Epididymis fat weight3.010.418.2-3.9-3.8-3.63.63.5-4.2-3.5-4.3-2.61.3-2.2-2.4-1.3
Delta time in closed arm before/after self-admin0.80.81.80.50.30.4-0.5-0.41.30.51.21.30.70.71.21.1
Delta time in open arm before/after self-admin0.30.30.50.40.60.6-0.5-0.6-0.50.5-0.60.3-0.30.2-0.7-0.6
Diff in mean of infusions in LGA sessions0.60.71.21.01.11.1-1.1-1.10.51.10.60.8-0.30.80.20.7
Delay discount exponential model param0.30.41.30.10.10.5-0.5-0.5-0.30.5-0.51.11.00.80.10.7
Extinction: sum of active levers before priming1.61.83.81.81.81.5-1.5-1.51.51.31.40.1-1.90.2-0.2-0.1
Active lever presses in extinction session 62.42.44.11.91.92.0-1.9-2.01.41.91.51.3-0.71.20.60.4
Bone: final force1.62.54.02.01.91.9-1.9-1.81.81.81.91.0-1.31.01.00.5
Bone: final moment1.42.33.71.91.81.8-1.8-1.71.81.71.81.0-1.30.91.00.5
Food consumed during 24 hour testing period0.10.20.40.10.20.4-0.4-0.4-0.40.4-0.40.70.30.60.10.3
Glucose3.45.47.8-2.1-2.2-2.62.62.6-2.0-2.7-1.9-2.8-0.6-2.8-2.2-2.3
Heart weight1.72.75.9-1.3-1.1-2.01.92.1-0.7-2.1-0.7-1.8-0.9-2.4-1.7-1.5
Delay discount hyperbolic model param0.40.41.40.20.10.5-0.5-0.6-0.20.6-0.41.21.00.90.20.8
Intermittent access intake day 1-15 change0.51.12.4-1.3-1.2-1.01.01.0-1.5-0.9-1.5-0.51.1-0.3-0.6-0.1
Intermittent access intake escalation0.40.82.1-1.2-1.0-0.80.80.7-1.5-0.7-1.5-0.41.1-0.1-0.5-0.1
Intermittent access intake escalation 20.91.03.0-1.3-1.1-0.80.90.8-1.7-0.8-1.7-0.41.1-0.1-0.6-0.2
Intermitt. access day 1 inactive lever presses0.00.10.6-0.4-0.0-0.20.30.2-0.8-0.2-0.6-0.10.3-0.1-0.5-0.5
Intermitt. access day 15 inactive lever presses0.91.93.5-1.3-1.0-1.21.31.2-1.9-1.3-1.7-1.6-0.0-1.2-1.6-1.7
Intermitt. access escalation Index2.63.75.7-2.3-2.4-2.42.32.4-1.8-2.3-2.0-1.60.6-1.7-1.1-0.7
Intermittent access day 1 total infusions3.45.59.5-1.7-1.5-2.32.42.4-2.0-2.5-1.7-3.1-1.5-3.0-2.9-2.7
Intermittent access day 15 total infusions3.95.88.9-2.5-2.2-2.52.62.5-3.0-2.6-2.9-2.60.1-2.1-2.5-1.9
Intermittent access terminal intake (last 3 days)4.45.88.9-2.3-1.9-2.42.52.4-3.0-2.5-2.7-2.7-0.3-2.3-2.8-2.5
Intermittent access total infusions4.04.77.6-1.8-1.5-2.22.32.2-2.2-2.3-2.0-2.8-0.9-2.4-2.6-2.4
Intermittent access day 1 locomotion2.73.55.7-1.4-1.1-1.92.01.9-1.6-2.0-1.4-2.4-1.0-2.3-2.2-2.2
Intermittent access day 15 total locomotion2.95.26.9-2.2-2.0-2.32.42.3-2.6-2.4-2.6-2.6-0.2-2.2-2.5-2.1
Intermittent access total locomotion7.38.812.9-2.8-2.4-3.03.23.1-3.2-3.2-3.0-3.6-0.7-3.1-3.3-2.9
Intermittent access standard deviation0.51.01.9-1.3-1.1-1.11.11.1-1.4-1.0-1.3-0.51.1-0.4-0.4-0.4
Left kidney weight0.73.15.2-2.2-2.3-2.12.02.1-1.9-2.0-1.9-1.00.9-1.3-1.1-0.0
Right kidney weight0.31.42.6-1.6-1.6-1.31.21.2-1.4-1.1-1.5-0.31.3-0.2-0.10.9
Cocaine induced anxiety0.00.10.20.20.30.3-0.2-0.2-0.10.2-0.2-0.0-0.30.0-0.3-0.5
Post-drug Anxiety0.50.51.00.90.91.0-0.9-1.00.50.90.30.5-0.60.60.10.0
Baseline Anxiety0.30.40.70.60.30.6-0.6-0.60.50.70.40.70.10.70.70.8
Tail length0.83.36.31.21.31.5-1.6-1.61.91.71.92.31.02.12.52.3
Length with tail2.19.111.23.03.03.2-3.2-3.23.33.33.33.30.03.03.22.7
Length without tail2.27.08.62.72.62.9-2.9-2.92.92.92.92.90.02.62.72.0
Times rat made contact with spout0.40.41.40.80.70.5-0.5-0.51.10.51.20.1-0.80.00.40.0
Lifetime Intake2.73.35.4-1.5-1.2-1.91.91.9-1.8-2.0-1.6-2.3-0.8-2.2-2.2-1.9
Liver weight, left0.61.02.9-1.3-1.3-1.11.01.1-0.7-0.9-0.70.31.70.00.60.9
Liver weight, right1.22.14.2-2.0-1.9-2.01.81.9-1.1-1.8-1.1-0.61.6-0.80.30.3
Locomotor activity1.01.54.3-1.7-1.6-1.31.21.3-0.8-1.1-0.8-0.12.10.21.20.8
Locomotor testing distance1.12.04.9-2.0-1.8-1.61.51.6-0.9-1.4-0.9-0.12.20.11.40.8
Locomotor testing rearing1.12.23.8-1.9-1.9-2.01.91.9-1.3-1.8-1.2-0.91.2-1.00.0-0.4
Locomotion in novel chamber4.55.78.8-2.9-2.9-2.72.72.7-2.9-2.6-3.0-2.31.0-1.7-1.5-1.1
Locomotion in novel chamber post-restriction2.13.55.9-2.2-2.1-2.12.12.0-2.4-2.0-2.3-1.60.9-1.3-1.4-1.0
Fecal boli incidents, locomotor time 10.10.20.70.10.20.2-0.2-0.2-0.70.2-0.80.40.10.1-0.8-0.7
Change in fecal boli incidents, locomotor task0.20.20.7-0.1-0.2-0.30.30.30.7-0.30.9-0.8-0.4-0.40.40.2
Time >=10cm from walls, locomotor time 12.32.55.8-0.9-0.8-1.21.31.3-1.0-1.4-0.9-2.4-1.5-2.0-2.1-2.3
Bouts of movement, locomotor time 11.11.32.71.41.61.4-1.4-1.41.11.41.00.8-0.40.90.50.2
Total resting periods, locomotor time 10.70.71.81.11.41.1-1.0-1.10.71.00.70.4-0.60.50.0-0.2
Rest time, locomotor task time 11.11.32.8-1.5-1.4-1.21.21.2-1.7-1.1-1.4-1.10.8-0.5-0.4-0.6
Distance moved, locomotor task time 10.20.31.40.50.40.1-0.1-0.00.5-0.10.6-0.7-1.2-0.7-0.6-0.7
Vertical activity count, locomotor time 10.20.50.8-0.9-0.9-0.90.90.9-0.5-0.9-0.4-0.50.5-0.5-0.30.1
Time >=10cm from walls, locomotor time 20.10.10.5-0.00.10.00.0-0.0-0.3-0.0-0.3-0.7-0.6-0.2-0.5-0.5
Bouts of movement, locomotor time 20.30.40.80.90.90.8-0.7-0.70.70.70.70.6-0.50.2-0.0-0.3
Total resting periods, locomotor time 20.10.20.30.60.60.4-0.4-0.40.30.30.30.4-0.5-0.1-0.4-0.5
Rest time, locomotor task time 21.72.23.5-1.9-1.7-1.81.81.8-1.7-1.7-1.6-0.91.0-1.0-0.8-0.7
Distance moved, locomotor task time 21.11.41.91.31.41.4-1.4-1.41.31.31.40.4-0.60.90.80.8
Vertical activity count, locomotor time 20.81.13.70.20.20.6-0.6-0.60.70.70.71.11.31.41.71.9
Light reinforcement 10.00.10.4-0.4-0.6-0.40.40.4-0.1-0.4-0.1-0.40.1-0.10.30.2
Light reinforcement 20.60.92.1-1.1-0.9-0.90.90.8-1.5-0.9-1.5-1.00.1-0.5-0.7-0.7
Bone: marrow area1.73.76.1-1.6-1.7-2.02.12.1-1.6-2.2-1.5-2.5-1.3-2.4-1.9-2.0
Bone: maximum diameter0.10.10.50.30.20.4-0.4-0.5-0.40.4-0.4-0.3-0.70.1-0.4-0.2
Bone: maximum force1.83.27.92.42.42.1-2.0-2.01.81.81.90.0-2.80.3-0.1-0.9
Bone: maximum moment1.73.07.32.32.21.9-1.9-1.91.81.71.90.0-2.70.20.0-0.8
Mean time between licks in bursts0.20.61.80.60.50.5-0.6-0.51.10.61.10.70.20.61.30.8
Mean num. licks in bursts0.10.20.5-0.6-0.6-0.70.60.7-0.2-0.7-0.1-0.20.3-0.5-0.2-0.0
Cd content in liver1.31.42.4-1.2-1.2-1.21.31.2-1.5-1.2-1.5-1.30.2-1.0-1.3-0.8
Co content in liver1.21.46.6-1.3-1.4-0.80.70.8-0.6-0.5-0.60.92.60.91.61.2
Cu content in liver0.10.10.30.1-0.1-0.20.10.20.1-0.20.1-0.4-0.6-0.5-0.4-0.5
Fe content in liver0.30.40.70.50.30.6-0.6-0.60.50.70.50.80.30.80.80.5
K content in liver0.30.30.80.70.80.5-0.5-0.40.80.40.90.0-0.8-0.10.0-0.4
Mg content in liver0.50.51.2-0.6-0.5-0.80.80.8-0.4-0.8-0.3-0.8-0.2-0.9-0.5-1.1
Mn content in liver2.62.95.92.22.42.2-2.1-2.21.42.11.41.1-1.31.10.2-0.2
Na content in liver0.60.61.40.50.40.9-0.9-0.90.41.00.40.60.31.21.00.9
Rb content in liver1.72.03.0-1.5-1.5-1.71.71.7-1.2-1.7-1.0-1.40.1-1.5-1.0-1.4
Se content in liver0.30.41.1-0.2-0.3-0.30.40.3-0.8-0.4-0.8-0.7-0.5-0.6-1.1-0.8
Sr content in liver2.62.33.31.61.61.8-1.8-1.81.41.81.21.60.11.61.11.4
Zn content in liver0.20.20.50.50.50.4-0.5-0.40.70.40.70.5-0.20.20.30.5
Bone: minimum diameter2.03.77.3-1.1-1.3-1.71.81.8-1.3-1.9-1.2-2.7-1.9-2.6-2.3-2.6
Time in familiar zone, hab. session 10.60.61.5-0.4-0.3-0.60.60.6-0.6-0.7-0.6-1.0-0.6-0.9-0.9-1.2
Time in novel zone, hab. session 10.40.41.6-0.4-0.5-0.30.20.20.0-0.10.00.61.30.50.91.0
Total zone transitions, hab. session 10.50.81.61.11.30.9-0.9-0.91.10.91.10.3-1.00.30.30.1
Total locomotion distance, hab. session 10.40.50.9-0.8-0.6-0.80.80.8-0.7-0.8-0.7-1.0-0.2-0.8-0.6-0.6
Locomotion velocity, hab. session 10.10.10.3-0.2-0.1-0.30.30.3-0.1-0.3-0.1-0.5-0.4-0.4-0.2-0.3
Time in familiar zone, hab. session 20.30.30.90.10.20.2-0.3-0.20.50.30.50.90.90.60.90.5
Time in novel zone, hab. session 20.30.31.00.1-0.1-0.20.20.2-0.1-0.3-0.1-0.8-1.0-0.8-0.8-0.5
Total zone transitions, hab. session 21.51.98.41.31.30.4-0.3-0.31.20.11.3-1.5-2.9-1.5-1.1-2.0
Total locomotion distance, hab. session 20.81.13.1-0.2-0.1-0.70.70.80.1-0.90.1-1.8-1.4-1.6-1.0-1.7
Locomotion velocity, hab. session 21.01.43.9-0.4-0.3-0.90.91.0-0.2-1.1-0.2-2.0-1.5-1.7-1.2-1.9
Novel to familiar place preference ratio0.50.62.01.00.80.9-0.8-0.80.00.70.0-0.3-1.4-0.1-1.0-0.6
Novelty place preference0.40.41.50.60.40.5-0.4-0.4-0.30.3-0.3-0.6-1.2-0.3-1.2-0.7
Time in novel zone, NPP test0.30.31.20.50.30.3-0.3-0.3-0.30.2-0.3-0.6-1.1-0.4-1.1-0.6
Total zone transitions, NPP test1.31.93.71.81.91.3-1.3-1.31.81.21.90.0-1.90.10.5-0.4
Total locomotion distance, NPP test0.10.20.60.10.2-0.20.10.20.4-0.20.5-0.6-0.8-0.50.2-0.4
Locomotion velocity, NPP test0.10.20.60.20.3-0.10.00.10.4-0.10.5-0.6-0.8-0.40.2-0.3
Intraocular pressure0.71.03.4-1.1-1.0-0.70.70.6-1.8-0.6-1.80.11.50.2-0.80.0
Delta distance traveled before/after self-admin0.10.10.7-0.2-0.4-0.10.00.0-0.10.0-0.00.60.80.40.50.4
Delta ambulatory time before/after self-admin0.10.20.5-0.1-0.20.1-0.1-0.10.20.20.30.70.70.50.60.5
Parametrial fat weight3.48.011.2-3.2-3.1-3.23.23.2-3.3-3.2-3.3-2.31.1-2.4-2.4-1.5
Pavlov. Cond. lever latency0.10.20.3-0.5-0.6-0.40.50.4-0.5-0.4-0.5-0.40.4-0.1-0.00.1
Pavlov. Cond. magazine entry latency0.40.52.00.40.50.1-0.0-0.00.1-0.10.1-0.9-1.4-0.8-1.0-1.1
Pavlov. Cond. change in total contacts0.30.31.20.20.40.2-0.1-0.2-0.50.1-0.5-0.6-1.0-0.5-1.1-0.8
Pavlov. Cond. index score0.10.10.20.40.50.4-0.4-0.40.10.30.00.0-0.50.0-0.2-0.2
Pavlov. Cond. latency score0.00.10.20.20.30.2-0.2-0.20.00.10.0-0.1-0.4-0.2-0.3-0.4
Pavlov. Cond. lever contacts0.00.00.10.20.20.1-0.1-0.10.20.10.20.1-0.4-0.1-0.1-0.2
Pavlov. Cond. magazine entry number0.10.20.4-0.5-0.7-0.60.60.6-0.1-0.6-0.0-0.10.4-0.30.10.1
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.5-0.5-0.20.20.2-0.6-0.2-0.60.20.70.2-0.00.4
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.50.60.5-0.5-0.50.20.40.2-0.0-0.7-0.0-0.3-0.2
Pavlov. Cond. response bias0.10.10.30.50.60.5-0.5-0.50.20.50.10.2-0.30.3-0.00.1
Pavlov. Cond. lever latency0.40.61.0-0.9-0.9-1.01.01.0-0.4-1.0-0.5-0.70.5-0.6-0.3-0.1
Pavlov. Cond. magazine entry latency3.13.87.82.72.82.2-2.1-2.22.12.02.20.4-2.50.50.2-0.6
Pavlov. Cond. change in total contacts1.01.64.71.71.71.5-1.3-1.40.61.20.6-0.3-2.20.0-0.8-1.1
Pavlov. Cond. index score1.72.24.52.12.11.8-1.7-1.81.31.61.40.4-2.00.5-0.0-0.5
Pavlov. Cond. latency score1.52.04.11.92.01.7-1.6-1.71.21.51.30.4-1.80.50.0-0.4
Pavlov. Cond. lever contacts0.40.51.01.00.91.0-0.9-1.00.50.90.50.5-0.70.50.1-0.1
Pavlov. Cond. magazine entry number4.96.012.2-3.3-3.5-2.92.82.9-2.6-2.6-2.6-0.82.9-0.9-0.30.5
Pavlov. Cond. intertrial magazine entries0.81.21.9-1.4-1.4-1.31.31.2-1.3-1.2-1.3-0.80.8-0.6-0.6-0.3
Pavlov. Cond. lever-magazine prob. diff.2.02.75.52.32.32.0-1.9-2.01.51.81.60.4-2.10.50.0-0.5
Pavlov. Cond. response bias1.31.83.51.91.91.6-1.6-1.61.21.51.20.5-1.70.4-0.0-0.5
Time in closed arm before self-admin0.81.02.4-0.6-0.4-0.70.80.8-1.1-0.9-0.9-1.6-0.8-1.1-1.2-1.4
Time in closed arm after self-admin0.10.10.2-0.4-0.3-0.40.40.4-0.1-0.4-0.1-0.30.2-0.30.0-0.4
Time in open arm before self-admin0.60.72.4-0.4-0.5-0.40.20.40.8-0.20.80.71.30.41.51.6
Time in open arm after self-admin0.10.10.60.20.20.3-0.3-0.30.20.30.10.80.40.40.30.5
Bone: periosteal estimation0.10.31.0-0.2-0.3-0.30.30.3-0.4-0.3-0.4-0.8-1.0-0.7-0.7-0.6
Bone: periosteal perimeter0.30.62.60.30.10.1-0.0-0.1-0.3-0.1-0.2-1.1-1.6-0.7-1.0-1.3
Bone: post-yield work3.45.018.80.70.8-0.30.50.5-0.3-0.8-0.2-3.3-4.3-3.0-3.5-3.5
Progressive ratio test 1 active lever presses0.20.30.7-0.2-0.0-0.40.40.4-0.6-0.4-0.5-0.8-0.5-0.6-0.8-0.7
Progressive ratio test 1 breakpoint0.20.20.7-0.20.1-0.30.30.3-0.5-0.3-0.5-0.8-0.5-0.5-0.8-0.7
Progressive ratio test 1 inactive lever presses0.10.10.3-0.1-0.0-0.20.20.2-0.2-0.2-0.1-0.5-0.3-0.3-0.5-0.5
Progressive ratio test 2 active lever presses2.12.53.8-1.4-1.2-1.51.61.5-1.9-1.6-1.7-2.0-0.3-1.5-1.8-1.6
Progressive ratio test 2 breakpoint2.02.33.5-1.4-1.2-1.41.51.5-1.9-1.5-1.7-1.9-0.3-1.4-1.8-1.5
Progressive ratio test 2 inactive lever presses5.48.711.9-3.2-2.9-3.23.33.2-3.4-3.3-3.3-3.20.3-2.6-2.8-2.2
Incentive Sensitization - Responses0.30.41.50.10.2-0.20.20.2-0.2-0.30.1-1.0-1.1-0.8-1.0-1.2
Incentive Sensitization - Breakpoint0.40.51.6-0.1-0.1-0.30.40.4-0.4-0.5-0.1-1.1-1.0-0.9-1.1-1.3
Sum of active levers in priming session hrs 5-62.32.14.61.21.11.9-1.8-2.00.52.00.41.60.62.21.01.3
Progressive ratio0.81.35.01.10.90.3-0.2-0.21.10.01.3-1.0-2.2-1.3-1.2-1.5
Food seeking constrained by brief footshock0.20.30.70.50.40.4-0.5-0.40.80.40.90.40.10.40.70.5
Seeking ratio, punishment vs. effort0.81.14.3-1.2-1.1-0.70.60.6-0.7-0.4-0.80.62.10.81.31.4
Retroperitoneal fat weight7.732.649.6-7.0-7.0-6.86.76.7-6.6-6.5-6.5-4.52.7-4.2-3.2-2.2
Reaction time number correct0.30.71.30.50.30.8-0.8-0.80.60.90.61.00.51.11.11.0
Reaction time mean minus median1.23.16.32.42.52.3-2.2-2.21.72.11.60.9-1.41.00.10.2
Reaction time mean minus median AUC0.92.33.91.82.01.9-1.8-1.91.51.81.31.3-0.31.30.80.8
Reaction time num false alarms0.30.51.7-0.5-0.7-0.30.20.30.2-0.10.20.71.30.71.31.1
Reaction time num false alarms AUC0.40.72.50.20.10.4-0.5-0.40.90.50.91.00.91.01.61.1
Reaction time trials correct on left0.30.71.30.50.30.8-0.8-0.80.60.90.61.00.51.11.11.0
Reaction time trials on left0.50.91.60.60.40.9-0.9-1.00.71.00.71.20.61.31.21.1
Reaction time mean0.00.00.20.20.40.2-0.2-0.2-0.00.1-0.2-0.1-0.2-0.1-0.4-0.1
Reaction time mean AUC0.00.10.40.10.30.1-0.0-0.1-0.20.0-0.3-0.3-0.3-0.2-0.6-0.3
Median of all reaction times0.20.30.5-0.4-0.3-0.50.50.5-0.6-0.5-0.6-0.6-0.0-0.5-0.7-0.5
Reaction time omissions1.52.23.81.92.01.9-1.9-1.91.41.81.31.3-0.61.20.60.6
Reaction time false alarm rate0.10.20.7-0.4-0.3-0.30.20.30.2-0.10.30.30.80.30.90.6
Reaction time premature initiation rate2.53.56.32.02.01.8-1.9-1.82.51.92.51.7-0.31.52.01.3
Reaction time premature initiations3.46.08.72.42.32.5-2.6-2.53.02.62.92.5-0.02.32.72.0
Std. dev. reaction times0.50.92.01.31.41.2-1.2-1.20.81.10.70.5-0.70.6-0.10.2
Reaction time trials completed0.50.91.60.60.40.9-0.9-1.00.71.00.71.20.61.31.21.1
Reaction time trials AUC0.30.61.40.40.20.7-0.7-0.80.60.80.61.00.61.11.20.9
Run reversals in cocaine runway, females0.40.42.00.60.50.2-0.2-0.11.40.11.40.1-0.7-0.40.5-0.1
Run reversals in cocaine runway, males1.01.04.6-0.4-0.50.1-0.2-0.2-0.30.4-0.41.32.21.41.31.4
Latency to leave start box in cocaine runway0.70.82.7-0.2-0.2-0.50.50.5-0.7-0.6-0.5-1.2-1.1-1.2-1.4-1.7
Latency to leave start box in cocaine runway, F0.30.41.1-0.1-0.2-0.40.40.4-0.5-0.5-0.3-0.8-0.8-0.9-0.9-1.0
Latency to leave start box in cocaine runway, M0.20.20.80.30.30.2-0.2-0.2-0.20.10.0-0.4-0.7-0.2-0.5-0.9
Std. dev. time between licks in bursts0.60.82.9-0.1-0.30.0-0.2-0.10.70.20.71.11.40.91.71.5
Total sessions with >9 infusions0.40.51.80.20.3-0.20.30.30.2-0.40.4-1.0-1.3-1.0-0.9-0.9
Short access day 1 total inactive lever presses1.72.23.2-1.8-1.7-1.81.81.8-1.7-1.7-1.6-1.20.4-1.2-1.0-0.6
Short access day 10 total inactive lever presses0.10.20.4-0.6-0.2-0.50.50.5-0.5-0.5-0.50.00.6-0.2-0.1-0.3
Short access day 1 total infusions1.72.33.3-1.4-1.2-1.71.71.7-1.5-1.8-1.3-1.6-0.6-1.8-1.6-1.4
Short access day 10 total infusions2.02.55.7-0.3-0.1-1.01.11.1-0.6-1.3-0.3-2.3-2.3-2.3-2.4-2.4
Short access total infusions0.91.12.6-0.4-0.1-0.90.91.0-0.4-1.1-0.3-1.5-1.3-1.6-1.5-1.3
Short access day 1 locomotion1.51.83.1-1.1-0.8-1.41.41.4-1.3-1.4-1.1-1.7-0.5-1.6-1.5-1.7
Short access day 10 total locomotion0.91.72.9-1.0-0.8-1.31.41.3-1.0-1.4-0.8-1.7-0.7-1.7-1.6-1.7
Short access total locomotion1.72.03.7-1.1-0.9-1.41.51.5-1.3-1.5-1.0-1.9-0.7-1.7-1.7-1.8
One hour access (0.3 mA shock)4.95.67.8-2.7-2.3-2.72.82.7-2.8-2.7-2.5-2.30.9-2.0-1.9-1.6
Compulsive drug intake2.93.56.91.41.11.6-1.7-1.62.21.82.12.31.02.02.62.0
One hour access (shock baseline)5.28.012.7-3.0-2.5-3.03.13.0-3.6-3.0-3.3-3.00.3-2.5-2.9-2.2
Social response proportion0.50.51.30.91.00.8-0.7-0.70.60.60.6-0.5-1.1-0.0-0.3-0.7
Social responses0.20.30.40.60.60.6-0.6-0.60.60.60.60.3-0.00.50.50.2
Social time0.40.50.80.70.60.7-0.7-0.70.80.80.80.70.20.70.80.9
Soleus weight2.98.515.7-4.0-4.0-3.63.43.5-3.2-3.3-3.2-1.42.7-1.5-0.7-0.0
Bone: stiffness1.32.27.32.01.91.5-1.4-1.41.21.21.3-0.3-2.7-0.3-0.8-1.2
Tibialis anterior weight9.732.845.26.36.36.7-6.7-6.76.06.76.05.6-1.15.44.53.7
Time to tail flick, vehicle, before self-admin0.20.20.60.40.30.1-0.1-0.10.50.10.4-0.2-0.8-0.4-0.2-0.7
Time to tail flick, vehicle, after self-admin0.40.51.60.70.80.1-0.2-0.11.00.01.1-0.5-1.3-0.8-0.5-0.6
Time to tail flick, test, before self-admin2.22.23.9-1.4-1.3-1.81.81.8-0.8-1.9-0.8-2.0-0.5-1.9-1.2-1.4
Time to tail flick, test, after self-admin0.00.00.10.10.10.2-0.2-0.2-0.20.2-0.2-0.1-0.20.1-0.3-0.4
Delta time to tail flick, vehicle, before/after SA0.30.30.80.60.70.3-0.3-0.30.70.20.9-0.3-0.8-0.3-0.2-0.3
Delta time to tail flick, test, before/after SA2.92.95.81.31.32.0-1.9-2.00.82.10.62.31.12.41.51.8
Tibia length0.92.54.31.71.82.0-2.0-2.11.12.01.01.2-0.51.70.91.5
Ambulatory time before self-admin0.40.62.40.70.70.5-0.3-0.4-0.20.3-0.1-0.8-1.5-0.5-1.2-1.3
Ambulatory time after self-admin0.91.13.2-0.5-0.6-0.60.70.6-1.2-0.7-1.0-1.3-1.0-1.1-1.6-1.8
Bone: tissue strength0.10.10.40.10.1-0.10.10.1-0.1-0.1-0.1-0.5-0.6-0.4-0.4-0.5
Total heroin consumption3.43.96.52.62.42.5-2.5-2.52.02.42.11.2-1.41.40.80.8
Bone: trabecular number0.91.67.31.21.30.6-0.4-0.50.60.20.7-1.1-2.7-1.2-1.6-1.6
Bone: trabecular spacing0.40.51.9-0.8-0.9-0.70.60.6-0.2-0.5-0.20.41.40.20.80.8
Bone: trabecular thickness1.01.22.7-0.5-0.4-0.90.90.9-0.7-1.0-0.7-1.4-1.2-1.6-1.6-1.6
Bone: trabecular tissue density2.63.97.4-2.7-2.5-2.22.12.1-2.6-2.0-2.6-0.92.1-0.6-0.40.0
Water consumed over 24 hours0.71.01.61.31.21.1-1.1-1.11.31.01.30.7-0.80.60.70.3
Number of responses in last shaping day0.00.10.2-0.00.10.0-0.0-0.0-0.20.1-0.30.40.50.30.30.2