Hub : Genes

Brms1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Brms1 0.07 0.04 1.7e-05 0.04 0.04 0.04 0.04 5.7e-05 5.3e-05 1.7e-04 9.7e-05
2 Liver mRNA stability Brms1 0.06 0.04 1.4e-06 0.05 0.04 0.04 0.05 2.8e-06 2.1e-05 2.1e-05 6.5e-06
3 Adipose alternative TSS NM_001009605.1 0.03 0.02 4.9e-03 0 0.01 0.01 0 8.4e-02 2.2e-02 4.3e-02 8.4e-02
4 Adipose alternative TSS XM_063286834.1 0.04 0.02 6.5e-04 0.01 0.02 0.01 0.01 2.2e-02 6.6e-03 2.7e-02 3.9e-02
5 Adipose alternative TSS XM_063286834.1 0.02 0.02 6.4e-03 0 0.01 0 0 1.4e-01 2.2e-02 8.6e-02 1.2e-01
6 PL mRNA stability Brms1 0.03 0.02 5.4e-03 0.03 0.01 0.02 0.03 2.2e-04 9.2e-03 2.4e-03 6.8e-04
7 Adipose alternative TSS NM_001009605.1 0.03 0.02 2.8e-03 0 0.01 0 0 7.5e-02 1.5e-02 1.5e-01 1.3e-01
8 IL mRNA stability Brms1 0.26 0.18 3.0e-03 0.12 0.06 0.08 0.09 7.4e-04 1.4e-02 6.9e-03 3.1e-03
9 IC gene expression Brms1 0.12 0.09 5.3e-04 0.1 0.08 0.09 0.09 6.0e-05 2.3e-04 1.7e-04 1.0e-04
10 NAcc gene expression Brms1 0.12 0.07 2.7e-12 0.08 0.09 0.09 0.08 1.1e-12 6.0e-13 4.4e-13 1.2e-12
11 pVTA gene expression Brms1 0.05 0.03 6.5e-04 0.03 0.04 0.03 0.03 1.4e-03 2.3e-04 1.2e-03 9.9e-04
12 Brain gene expression Brms1 0.47 0.18 6.3e-06 0.07 0.06 0.07 0.07 9.0e-07 1.3e-06 1.6e-07 5.6e-07
13 PL gene expression Brms1 0.04 0.04 1.8e-03 0.01 0.02 0.02 0.01 1.7e-02 6.5e-03 4.1e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.81.57.30.9-0.90.2-0.1-0.1-0.6-0.1-0.71.32.7-1.51.51.8
Area under the delay curve0.30.51.6-0.20.2-0.60.60.7-0.2-0.7-0.41.31.0-1.00.30.9
BMI with tail1.34.519.32.5-2.51.2-1.2-1.1-2.20.8-2.41.14.4-1.61.52.3
BMI without tail0.42.06.61.7-1.80.9-0.9-0.8-2.10.6-2.20.32.6-0.80.30.9
Body weight1.98.215.13.7-3.83.1-3.1-3.0-3.82.8-3.9-1.52.91.0-1.2-0.4
Weight adjusted by age0.72.13.01.6-1.41.7-1.7-1.7-1.71.7-1.5-1.50.41.3-1.1-0.8
Bone surface2.44.714.23.0-2.92.3-2.2-2.2-2.11.9-2.20.33.8-0.20.71.3
Bone volume1.02.09.31.7-1.61.1-1.0-1.0-1.00.8-1.00.93.1-0.81.21.7
Breakpoint value in progressive ratio session1.62.95.02.2-2.22.1-2.1-2.1-1.72.0-1.7-0.91.61.0-0.5-0.3
Number of licking bursts0.10.30.60.8-0.70.7-0.7-0.7-0.50.6-0.5-0.00.70.2-0.20.2
Context. condit. distance diff. score1.61.93.0-1.71.7-1.71.61.71.5-1.61.50.7-1.1-1.00.80.3
Locomotion velocity, session 10.20.31.7-0.1-0.10.1-0.1-0.1-0.40.2-0.5-0.6-0.70.6-1.3-0.3
Locomotion distance, session 10.50.62.50.7-0.90.2-0.2-0.1-1.00.1-1.00.81.6-0.80.10.8
Locomotion velocity, session 21.82.24.11.9-1.91.6-1.6-1.5-2.01.5-2.0-0.81.20.7-1.0-0.2
Locomotion distance, session 20.50.82.31.0-1.10.6-0.6-0.5-1.40.5-1.50.21.3-0.2-0.50.3
Locomotion velocity, session 30.30.31.0-0.30.3-0.60.50.60.2-0.60.20.70.5-0.80.61.0
Locomotion distance, session 30.00.00.2-0.0-0.0-0.10.10.1-0.1-0.1-0.0-0.0-0.1-0.1-0.10.5
Stereotopy head waving bouts, day 30.91.01.8-1.01.1-1.31.31.40.6-1.30.50.9-0.0-1.30.61.0
Stereotopy head waving duration, day 31.21.52.2-1.21.2-1.41.41.51.1-1.51.01.20.1-1.41.11.0
Locomotion velocity, session 70.50.61.3-0.50.4-0.80.70.80.3-0.90.20.70.7-1.21.01.1
Locomotion distance, session 70.10.10.40.0-0.1-0.20.10.2-0.5-0.2-0.6-0.20.2-0.3-0.10.0
Stereotopy head waving bouts, day 70.70.82.8-0.10.2-0.30.40.40.8-0.50.81.01.0-1.01.61.7
Stereotopy head waving duration, day 70.60.72.50.9-0.80.6-0.5-0.5-0.10.3-0.10.51.6-0.61.41.5
Locomotion velocity, session 81.01.21.91.1-1.11.1-1.2-1.1-1.31.2-1.4-0.90.11.0-1.4-0.8
Locomotion distance, session 80.30.40.7-0.70.6-0.80.80.80.5-0.80.50.70.1-0.80.40.4
Degree of sensitization distance0.10.10.40.1-0.1-0.20.20.3-0.3-0.3-0.40.30.6-0.60.30.3
Degree of sensitization stereotypy0.40.51.40.7-0.70.6-0.5-0.60.20.50.10.21.1-0.21.21.1
Conditioned locomotion1.92.33.21.5-1.51.5-1.6-1.5-1.81.6-1.8-1.6-0.21.4-1.5-1.4
Cocaine response after cond. corrected0.60.91.7-1.31.2-1.21.11.20.9-1.11.00.3-1.1-0.50.2-0.1
Cocaine response after cond. not corrected0.50.71.2-1.11.0-1.01.01.00.9-1.00.90.6-0.6-0.60.40.2
Cocaine response before conditioning0.50.61.41.0-1.00.9-0.8-0.9-0.50.8-0.40.21.20.20.20.5
Saline control response2.73.76.42.5-2.12.2-2.1-2.1-2.52.0-2.5-0.91.81.0-1.2-0.4
Bone: connectivity density1.62.610.02.1-2.01.3-1.2-1.2-1.71.0-1.90.73.2-0.70.91.2
Bone: cortical apparent density0.30.40.80.4-0.40.5-0.6-0.6-0.50.6-0.4-0.9-0.70.8-0.7-0.8
Bone: cortical area0.71.11.81.2-1.11.3-1.3-1.3-0.91.3-0.9-0.90.41.1-0.7-0.8
Bone: cortical porosity0.10.20.70.3-0.30.00.00.0-0.5-0.1-0.50.30.9-0.60.30.5
Bone: cortical porosity0.30.30.80.7-0.60.4-0.4-0.3-0.90.3-0.9-0.10.9-0.2-0.00.1
Bone: cortical thickness4.57.59.92.6-2.53.0-3.1-3.0-2.63.1-2.6-3.2-0.63.0-2.8-2.6
Bone: cortical thickness1.82.24.51.0-0.91.2-1.3-1.3-1.61.4-1.6-1.9-1.01.7-2.1-1.5
Bone: cortical tissue density0.40.61.20.5-0.60.7-0.8-0.7-0.60.8-0.5-1.1-0.71.0-0.8-0.9
Condit. Reinf. active minus inactive responses0.20.30.70.6-0.80.4-0.4-0.4-0.50.3-0.50.20.8-0.20.10.7
Condit. Reinf. active-inactive response ratio0.10.10.30.2-0.50.1-0.1-0.1-0.10.1-0.10.30.5-0.20.30.6
Condit. Reinf. active responses0.10.10.50.4-0.70.3-0.3-0.3-0.40.2-0.40.20.6-0.20.10.3
Condit. Reinf. inactive responses0.00.00.1-0.10.0-0.20.10.20.1-0.20.10.20.2-0.30.20.1
Incentive salience index mean0.30.31.00.7-0.90.5-0.5-0.4-0.70.4-0.70.11.0-0.20.10.4
Condit. Reinf. lever presses0.30.41.00.8-1.00.8-0.8-0.7-0.60.7-0.6-0.30.80.3-0.0-0.3
Condit. Reinf. active minus inactive responses0.61.02.5-0.20.3-0.40.50.41.0-0.60.91.51.3-1.01.41.6
Condit. Reinf. active-inactive response ratio1.01.63.1-0.90.8-0.91.00.91.6-1.01.61.80.9-1.21.61.5
Condit. Reinf. active responses0.71.03.80.4-0.2-0.00.20.10.3-0.30.21.42.0-1.21.41.8
Condit. Reinf. inactive responses0.40.51.90.9-0.60.4-0.3-0.3-0.90.2-1.00.21.4-0.70.50.9
Condit. Reinf. lever presses1.21.84.41.9-1.81.6-1.5-1.5-1.01.4-1.1-0.12.10.20.40.8
Condit. Reinf. lever reinforcers received0.60.94.10.7-0.40.3-0.1-0.20.00.0-0.11.22.0-0.91.21.6
Conditioned reinforcement - actives0.00.10.20.00.10.3-0.2-0.30.50.30.40.1-0.10.40.10.0
Conditioned reinforcement - inactives1.02.75.2-1.91.6-1.71.81.72.3-1.72.11.6-0.6-1.21.51.2
Conditioned locomotion4.97.212.1-3.43.3-3.03.03.03.4-2.93.52.1-1.8-1.51.40.7
Patch foraging indifference point 0 sec0.10.41.5-0.30.6-0.40.40.40.3-0.50.31.20.8-0.70.70.6
Patch foraging indifference point AUC1.12.64.11.9-2.02.0-2.0-2.0-1.32.0-1.3-1.70.41.5-0.6-0.7
Delay disc. indifference point, 0s delay0.80.91.9-0.90.9-1.31.31.40.1-1.3-0.11.10.2-1.30.20.5
Delay disc. indifference point, 16s delay0.91.22.6-0.90.8-1.01.11.11.0-1.10.81.60.8-1.31.21.4
Delay disc. indifference point, 2s delay0.30.30.7-0.40.4-0.60.60.60.4-0.70.30.90.5-0.80.50.7
Delay disc. indifference point, 24s delay0.10.10.7-0.20.2-0.20.10.2-0.4-0.1-0.4-0.1-0.50.3-0.9-0.6
Delay disc. indifference point, 4s delay0.30.30.7-0.40.2-0.70.70.8-0.3-0.8-0.40.80.5-0.8-0.10.2
Delay disc. indifference point, 8s delay0.20.30.8-0.20.2-0.50.50.6-0.3-0.6-0.40.90.5-0.7-0.10.4
Indifference point function ln k2.57.714.5-3.73.8-3.53.43.42.7-3.32.72.0-2.0-1.70.50.4
Indifference point function log k2.57.714.5-3.73.8-3.53.43.42.7-3.32.72.0-2.0-1.70.50.4
Patch foraging total patch changes 0 sec0.00.10.3-0.20.5-0.10.10.1-0.0-0.1-0.00.60.2-0.1-0.10.0
Patch foraging total patch changes 12 sec2.93.97.12.7-2.42.4-2.4-2.3-2.22.2-2.2-1.41.61.1-0.5-0.5
Patch foraging total patch changes 18 sec0.20.51.11.0-1.10.8-0.7-0.7-0.70.7-0.7-0.10.90.10.30.3
Patch foraging total patch changes 24 sec0.62.23.11.7-1.61.8-1.8-1.8-1.61.8-1.5-1.20.31.4-1.1-0.9
Patch foraging total patch changes 6 sec0.71.22.31.5-1.31.3-1.2-1.2-1.31.1-1.3-0.41.20.3-0.00.4
Patch foraging time to switch 0 sec0.51.96.51.8-1.91.1-1.1-1.0-1.40.8-1.40.62.5-0.71.01.0
Patch foraging water rate 0 sec1.04.08.7-2.82.8-2.01.91.92.4-1.72.40.2-2.90.2-0.5-1.0
Patch foraging water rate 12 sec2.08.117.3-3.94.2-3.33.13.12.8-2.92.90.7-3.8-0.5-0.8-1.1
Patch foraging water rate 18 sec1.12.55.7-2.22.4-1.91.81.81.4-1.71.40.6-1.9-0.4-0.5-0.4
Patch foraging water rate 24 sec2.73.88.9-2.82.6-2.22.02.02.1-1.82.10.0-3.0-0.0-0.6-0.9
Patch foraging water rate 6 sec2.43.59.0-2.62.7-2.01.91.91.6-1.71.60.1-3.00.2-1.4-1.4
Seeking ratio, delayed vs. immediate footshock0.30.51.8-0.20.0-0.50.60.6-0.3-0.7-0.21.41.0-1.10.70.7
Distance traveled before self-admin0.20.41.80.7-0.60.5-0.4-0.5-0.10.4-0.20.51.4-0.30.70.8
Distance traveled after self-admin0.10.20.50.5-0.30.5-0.4-0.50.10.4-0.1-0.00.60.10.30.7
Extensor digitorum longus weight6.224.736.35.9-6.05.7-5.8-5.7-5.85.6-5.8-4.32.43.7-3.3-2.3
Bone: elastic displacement0.81.04.7-0.80.8-0.30.20.20.20.00.2-1.0-2.21.1-1.6-1.5
Bone: elastic work2.12.75.11.3-1.11.5-1.6-1.6-1.71.7-1.7-1.9-0.71.9-2.3-1.8
Bone: endosteal estimation1.43.55.7-1.51.7-1.92.02.01.5-2.11.42.41.3-2.41.81.9
Bone: endosteal perimeter2.45.911.8-1.71.8-2.12.22.22.3-2.32.13.42.0-2.92.83.1
Epididymis fat weight2.110.418.2-3.93.8-3.63.63.54.2-3.54.32.6-1.3-2.22.41.3
Delta time in closed arm before/after self-admin0.80.81.80.5-0.30.4-0.5-0.4-1.30.5-1.2-1.3-0.70.7-1.2-1.1
Delta time in open arm before/after self-admin0.20.30.50.4-0.60.6-0.5-0.60.50.50.6-0.30.30.20.70.6
Diff in mean of infusions in LGA sessions0.40.71.21.0-1.11.1-1.1-1.1-0.51.1-0.6-0.80.30.8-0.2-0.7
Delay discount exponential model param0.30.41.30.1-0.10.5-0.5-0.50.30.50.5-1.1-1.00.8-0.1-0.7
Extinction: sum of active levers before priming1.21.83.81.8-1.81.5-1.5-1.5-1.51.3-1.4-0.11.90.20.20.1
Active lever presses in extinction session 62.42.44.11.9-1.92.0-1.9-2.0-1.41.9-1.5-1.30.71.2-0.6-0.4
Bone: final force1.52.54.02.0-1.91.9-1.9-1.8-1.81.8-1.9-1.01.31.0-1.0-0.5
Bone: final moment1.42.33.71.9-1.81.8-1.8-1.7-1.81.7-1.8-1.01.30.9-1.0-0.5
Food consumed during 24 hour testing period0.10.20.40.1-0.20.4-0.4-0.40.40.40.4-0.7-0.30.6-0.1-0.3
Glucose3.45.47.8-2.12.2-2.62.62.62.0-2.71.92.80.6-2.82.22.3
Heart weight1.72.75.9-1.31.1-2.01.92.10.7-2.10.71.80.9-2.41.71.5
Delay discount hyperbolic model param0.30.41.40.2-0.10.5-0.5-0.60.20.60.4-1.2-1.00.9-0.2-0.8
Intermittent access intake day 1-15 change0.21.12.4-1.31.2-1.01.01.01.5-0.91.50.5-1.1-0.30.60.1
Intermittent access intake escalation0.10.82.1-1.21.0-0.80.80.71.5-0.71.50.4-1.1-0.10.50.1
Intermittent access intake escalation 20.61.03.0-1.31.1-0.80.90.81.7-0.81.70.4-1.1-0.10.60.2
Intermitt. access day 1 inactive lever presses0.00.10.6-0.40.0-0.20.30.20.8-0.20.60.1-0.3-0.10.50.5
Intermitt. access day 15 inactive lever presses0.41.93.5-1.31.0-1.21.31.21.9-1.31.71.60.0-1.21.61.7
Intermitt. access escalation Index1.23.75.7-2.32.4-2.42.32.41.8-2.32.01.6-0.6-1.71.10.7
Intermittent access day 1 total infusions1.85.59.5-1.71.5-2.32.42.42.0-2.51.73.11.5-3.02.92.7
Intermittent access day 15 total infusions2.45.88.9-2.52.2-2.52.62.53.0-2.62.92.6-0.1-2.12.51.9
Intermittent access terminal intake (last 3 days)3.35.88.9-2.31.9-2.42.52.43.0-2.52.72.70.3-2.32.82.4
Intermittent access total infusions4.04.77.6-1.81.5-2.22.32.22.2-2.32.02.80.9-2.42.62.4
Intermittent access day 1 locomotion1.93.55.7-1.41.1-1.92.01.91.6-2.01.42.41.0-2.32.22.2
Intermittent access day 15 total locomotion1.35.26.9-2.22.0-2.32.42.32.6-2.42.62.60.2-2.22.52.1
Intermittent access total locomotion7.38.812.9-2.82.4-3.03.23.13.2-3.23.03.60.7-3.13.32.9
Intermittent access standard deviation0.21.01.9-1.31.1-1.11.11.11.4-1.01.30.5-1.1-0.40.40.4
Left kidney weight0.43.15.2-2.22.3-2.12.02.11.9-2.01.91.0-0.9-1.31.10.0
Right kidney weight0.21.42.6-1.61.6-1.31.21.21.4-1.11.50.3-1.3-0.20.1-0.9
Cocaine induced anxiety0.00.10.20.2-0.30.3-0.2-0.20.10.20.20.00.30.00.30.5
Post-drug Anxiety0.50.51.00.9-0.91.0-0.9-1.0-0.50.9-0.3-0.50.60.6-0.1-0.0
Baseline Anxiety0.20.40.70.6-0.30.6-0.6-0.6-0.50.7-0.4-0.7-0.10.7-0.7-0.8
Tail length0.63.36.31.2-1.31.5-1.6-1.6-1.91.7-1.9-2.3-1.02.1-2.5-2.3
Length with tail2.09.111.23.0-3.03.2-3.2-3.2-3.33.3-3.3-3.3-0.03.0-3.2-2.7
Length without tail1.37.08.62.7-2.62.9-2.9-2.9-2.92.9-2.9-2.9-0.02.6-2.7-2.0
Times rat made contact with spout0.40.41.40.8-0.70.5-0.5-0.5-1.10.5-1.2-0.10.80.0-0.4-0.0
Lifetime Intake2.73.35.4-1.51.2-1.91.91.91.8-2.01.62.30.8-2.22.21.9
Liver weight, left0.61.02.9-1.31.3-1.11.01.10.7-0.90.7-0.3-1.70.0-0.6-0.9
Liver weight, right1.22.14.2-2.01.9-2.01.81.91.1-1.81.10.6-1.6-0.8-0.3-0.3
Locomotor activity1.01.54.3-1.71.6-1.31.21.30.8-1.10.80.1-2.10.2-1.2-0.8
Locomotor testing distance0.82.04.9-2.01.8-1.61.51.60.9-1.40.90.1-2.20.1-1.4-0.8
Locomotor testing rearing0.62.23.8-1.91.9-2.01.91.91.3-1.81.20.9-1.2-1.0-0.00.4
Locomotion in novel chamber4.35.78.8-2.92.9-2.72.72.72.9-2.63.02.3-1.0-1.71.51.1
Locomotion in novel chamber post-restriction1.13.45.9-2.22.1-2.12.12.02.4-2.02.31.6-0.9-1.31.41.0
Fecal boli incidents, locomotor time 10.10.20.70.1-0.20.2-0.2-0.20.70.20.8-0.4-0.10.10.80.7
Change in fecal boli incidents, locomotor task0.20.20.7-0.10.2-0.30.30.3-0.7-0.3-0.90.80.4-0.4-0.4-0.2
Time >=10cm from walls, locomotor time 12.02.55.8-0.90.8-1.21.31.31.0-1.40.92.41.5-2.02.12.3
Bouts of movement, locomotor time 11.01.32.71.4-1.61.4-1.4-1.4-1.11.4-1.0-0.80.40.9-0.5-0.2
Total resting periods, locomotor time 10.60.71.81.1-1.41.1-1.0-1.1-0.71.0-0.7-0.40.60.5-0.00.2
Rest time, locomotor task time 10.81.32.8-1.51.4-1.21.21.21.7-1.11.41.1-0.8-0.50.40.6
Distance moved, locomotor task time 10.10.31.40.5-0.40.1-0.1-0.0-0.5-0.1-0.60.71.2-0.70.60.7
Vertical activity count, locomotor time 10.10.50.8-0.90.9-0.90.90.90.5-0.90.40.5-0.5-0.50.3-0.1
Time >=10cm from walls, locomotor time 20.00.10.5-0.0-0.10.00.0-0.00.3-0.00.30.70.6-0.20.50.5
Bouts of movement, locomotor time 20.10.40.80.9-0.90.8-0.7-0.7-0.70.7-0.7-0.60.50.20.00.3
Total resting periods, locomotor time 20.00.20.30.6-0.60.4-0.4-0.4-0.30.3-0.3-0.40.5-0.10.40.5
Rest time, locomotor task time 21.32.23.5-1.91.7-1.81.81.81.7-1.71.60.9-1.0-1.00.80.7
Distance moved, locomotor task time 21.01.41.91.3-1.41.4-1.4-1.4-1.31.3-1.4-0.40.60.9-0.8-0.8
Vertical activity count, locomotor time 20.51.13.70.2-0.20.6-0.6-0.6-0.70.7-0.7-1.1-1.31.4-1.7-1.9
Light reinforcement 10.00.10.4-0.40.6-0.40.40.40.1-0.40.10.4-0.1-0.1-0.3-0.2
Light reinforcement 20.40.92.1-1.10.9-0.90.90.81.5-0.91.51.0-0.1-0.50.70.7
Bone: marrow area1.53.76.1-1.61.7-2.02.12.11.6-2.21.52.51.3-2.41.92.0
Bone: maximum diameter0.10.10.50.3-0.20.4-0.4-0.50.40.40.40.30.70.10.40.2
Bone: maximum force1.63.27.92.4-2.42.1-2.0-2.0-1.81.8-1.9-0.02.80.30.10.9
Bone: maximum moment1.63.07.32.3-2.21.9-1.9-1.9-1.81.7-1.9-0.02.70.2-0.00.8
Mean time between licks in bursts0.10.61.80.6-0.50.5-0.6-0.5-1.10.6-1.1-0.7-0.20.6-1.3-0.8
Mean num. licks in bursts0.10.20.5-0.60.6-0.70.60.70.2-0.70.10.2-0.3-0.50.20.0
Cd content in liver1.31.42.4-1.21.2-1.21.31.21.5-1.21.51.3-0.2-1.01.30.8
Co content in liver1.21.46.6-1.31.4-0.80.70.80.6-0.50.6-0.9-2.60.9-1.6-1.2
Cu content in liver0.10.10.30.10.1-0.20.10.2-0.1-0.2-0.10.40.6-0.50.40.5
Fe content in liver0.30.40.70.5-0.30.6-0.6-0.6-0.50.7-0.5-0.8-0.30.8-0.8-0.5
K content in liver0.30.30.80.7-0.80.5-0.5-0.4-0.80.4-0.9-0.00.8-0.1-0.00.4
Mg content in liver0.50.51.2-0.60.5-0.80.80.80.4-0.80.30.80.2-0.90.51.1
Mn content in liver2.62.95.92.2-2.42.2-2.1-2.2-1.42.1-1.4-1.11.31.1-0.20.2
Na content in liver0.50.61.40.5-0.40.9-0.9-0.9-0.41.0-0.4-0.6-0.31.2-1.0-0.9
Rb content in liver1.72.03.0-1.51.5-1.71.71.71.2-1.71.01.4-0.1-1.51.01.4
Se content in liver0.30.41.1-0.20.3-0.30.40.30.8-0.40.80.70.5-0.61.10.8
Sr content in liver2.62.33.31.6-1.61.8-1.8-1.8-1.41.8-1.2-1.6-0.11.6-1.1-1.4
Zn content in liver0.20.20.50.5-0.50.4-0.5-0.4-0.70.4-0.7-0.50.20.2-0.3-0.5
Bone: minimum diameter1.93.77.3-1.11.3-1.71.81.81.3-1.91.22.71.9-2.62.32.6
Time in familiar zone, hab. session 10.50.61.5-0.40.3-0.60.60.60.6-0.70.61.00.6-0.90.91.2
Time in novel zone, hab. session 10.30.41.6-0.40.5-0.30.20.2-0.0-0.1-0.0-0.6-1.30.5-0.9-1.0
Total zone transitions, hab. session 10.50.81.61.1-1.30.9-0.9-0.9-1.10.9-1.1-0.31.00.3-0.3-0.1
Total locomotion distance, hab. session 10.40.50.9-0.80.6-0.80.80.80.7-0.80.71.00.2-0.80.60.6
Locomotion velocity, hab. session 10.10.10.3-0.20.1-0.30.30.30.1-0.30.10.50.4-0.40.20.3
Time in familiar zone, hab. session 20.30.30.90.1-0.20.2-0.3-0.2-0.50.3-0.5-0.9-0.90.6-0.9-0.5
Time in novel zone, hab. session 20.20.31.00.10.1-0.20.20.20.1-0.30.10.81.0-0.80.80.5
Total zone transitions, hab. session 21.51.98.41.3-1.30.4-0.3-0.3-1.20.1-1.31.52.9-1.51.12.0
Total locomotion distance, hab. session 20.81.13.1-0.20.1-0.70.70.8-0.1-0.9-0.11.81.4-1.61.01.7
Locomotion velocity, hab. session 21.01.43.9-0.40.3-0.90.91.00.2-1.10.22.01.5-1.71.21.9
Novel to familiar place preference ratio0.50.62.01.0-0.80.9-0.8-0.8-0.00.7-0.00.31.4-0.11.00.6
Novelty place preference0.30.41.50.6-0.40.5-0.4-0.40.30.30.30.61.2-0.31.20.7
Time in novel zone, NPP test0.30.31.20.5-0.30.3-0.3-0.30.30.20.30.61.1-0.41.10.6
Total zone transitions, NPP test1.31.93.71.8-1.91.3-1.3-1.3-1.81.2-1.9-0.01.90.1-0.50.4
Total locomotion distance, NPP test0.10.20.60.1-0.2-0.20.10.2-0.4-0.2-0.50.60.8-0.5-0.20.4
Locomotion velocity, NPP test0.10.20.60.2-0.3-0.10.00.1-0.4-0.1-0.50.60.8-0.4-0.20.3
Intraocular pressure0.61.03.4-1.11.0-0.70.70.61.8-0.61.8-0.1-1.50.20.8-0.0
Delta distance traveled before/after self-admin0.10.10.7-0.20.4-0.10.00.00.10.00.0-0.6-0.80.4-0.5-0.4
Delta ambulatory time before/after self-admin0.10.20.5-0.10.20.1-0.1-0.1-0.20.2-0.3-0.7-0.70.5-0.6-0.5
Parametrial fat weight3.48.011.2-3.23.1-3.23.23.23.3-3.23.32.3-1.1-2.42.41.5
Pavlov. Cond. lever latency0.10.20.3-0.50.6-0.40.50.40.5-0.40.50.4-0.4-0.10.0-0.1
Pavlov. Cond. magazine entry latency0.40.52.00.4-0.50.1-0.0-0.0-0.1-0.1-0.10.91.4-0.81.01.1
Pavlov. Cond. change in total contacts0.30.31.20.2-0.40.2-0.1-0.20.50.10.50.61.0-0.51.10.8
Pavlov. Cond. index score0.10.10.20.4-0.50.4-0.4-0.4-0.10.3-0.0-0.00.50.00.20.2
Pavlov. Cond. latency score0.00.10.20.2-0.30.2-0.2-0.2-0.00.1-0.00.10.4-0.20.30.4
Pavlov. Cond. lever contacts0.00.00.10.2-0.20.1-0.1-0.1-0.20.1-0.2-0.10.4-0.10.10.2
Pavlov. Cond. magazine entry number0.10.20.4-0.50.7-0.60.60.60.1-0.60.00.1-0.4-0.3-0.1-0.1
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.50.5-0.20.20.20.6-0.20.6-0.2-0.70.20.0-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.20.50.5-0.60.5-0.5-0.5-0.20.4-0.20.00.7-0.00.30.2
Pavlov. Cond. response bias0.10.10.30.5-0.60.5-0.5-0.5-0.20.5-0.1-0.20.30.30.0-0.1
Pavlov. Cond. lever latency0.40.61.0-0.90.9-1.01.01.00.4-1.00.50.7-0.5-0.60.30.1
Pavlov. Cond. magazine entry latency2.73.87.82.7-2.82.2-2.1-2.2-2.12.0-2.2-0.42.50.5-0.20.6
Pavlov. Cond. change in total contacts0.71.64.71.7-1.71.5-1.3-1.4-0.61.2-0.60.32.20.00.81.2
Pavlov. Cond. index score1.42.24.52.1-2.11.8-1.7-1.8-1.31.6-1.4-0.42.00.50.00.6
Pavlov. Cond. latency score1.22.04.11.9-2.01.7-1.6-1.7-1.21.5-1.3-0.41.80.5-0.00.5
Pavlov. Cond. lever contacts0.40.51.01.0-0.91.0-0.9-1.0-0.50.9-0.5-0.50.70.5-0.10.1
Pavlov. Cond. magazine entry number4.66.012.2-3.33.5-2.92.82.92.6-2.62.60.8-2.9-0.90.3-0.5
Pavlov. Cond. intertrial magazine entries0.51.21.9-1.41.4-1.31.31.21.3-1.21.30.8-0.8-0.60.60.2
Pavlov. Cond. lever-magazine prob. diff.1.82.75.52.3-2.32.0-1.9-2.0-1.51.8-1.6-0.42.10.5-0.00.6
Pavlov. Cond. response bias1.31.83.51.9-1.91.6-1.6-1.6-1.21.5-1.2-0.51.70.40.00.5
Time in closed arm before self-admin0.61.02.4-0.60.4-0.70.80.81.1-0.90.91.60.8-1.11.21.4
Time in closed arm after self-admin0.10.10.2-0.40.3-0.40.40.40.1-0.40.10.3-0.2-0.3-0.00.4
Time in open arm before self-admin0.60.72.4-0.40.5-0.40.20.4-0.8-0.2-0.8-0.7-1.30.4-1.5-1.6
Time in open arm after self-admin0.10.10.60.2-0.20.3-0.3-0.3-0.20.3-0.1-0.8-0.40.4-0.3-0.5
Bone: periosteal estimation0.10.31.0-0.20.3-0.30.30.30.4-0.30.40.81.0-0.70.70.6
Bone: periosteal perimeter0.30.62.60.3-0.10.1-0.0-0.10.3-0.10.21.11.6-0.71.01.3
Bone: post-yield work2.95.018.80.7-0.8-0.30.50.50.3-0.80.23.34.3-3.03.53.5
Progressive ratio test 1 active lever presses0.20.30.7-0.20.0-0.40.40.40.6-0.40.50.80.5-0.60.80.7
Progressive ratio test 1 breakpoint0.10.20.7-0.2-0.1-0.30.30.30.5-0.30.50.80.5-0.50.80.7
Progressive ratio test 1 inactive lever presses0.00.10.3-0.10.0-0.20.20.20.2-0.20.10.50.3-0.30.50.4
Progressive ratio test 2 active lever presses1.72.53.8-1.41.2-1.51.61.51.9-1.61.72.00.3-1.51.81.6
Progressive ratio test 2 breakpoint1.82.33.5-1.41.2-1.41.51.51.9-1.51.71.90.3-1.41.81.5
Progressive ratio test 2 inactive lever presses2.78.711.9-3.22.9-3.23.33.23.4-3.33.33.2-0.3-2.62.82.1
Incentive Sensitization - Responses0.20.41.50.1-0.2-0.20.20.20.2-0.3-0.11.01.1-0.81.01.2
Incentive Sensitization - Breakpoint0.20.51.6-0.10.1-0.30.40.40.4-0.50.11.11.0-0.91.11.3
Sum of active levers in priming session hrs 5-62.32.14.61.2-1.11.9-1.8-2.0-0.52.0-0.4-1.6-0.62.2-1.0-1.3
Progressive ratio0.41.35.01.1-0.90.3-0.2-0.2-1.10.0-1.31.02.2-1.31.21.5
Food seeking constrained by brief footshock0.20.30.70.5-0.40.4-0.5-0.4-0.80.4-0.9-0.4-0.10.4-0.7-0.5
Seeking ratio, punishment vs. effort0.51.14.3-1.21.1-0.70.60.60.7-0.40.8-0.6-2.10.8-1.3-1.4
Retroperitoneal fat weight7.332.649.6-7.07.0-6.86.76.76.6-6.56.54.5-2.7-4.23.22.2
Reaction time number correct0.20.71.30.5-0.30.8-0.8-0.8-0.60.9-0.6-1.0-0.51.1-1.1-1.0
Reaction time mean minus median0.53.16.32.4-2.52.3-2.2-2.2-1.72.1-1.6-0.91.41.0-0.1-0.2
Reaction time mean minus median AUC0.32.23.91.8-2.01.9-1.8-1.9-1.51.8-1.3-1.30.31.3-0.8-0.8
Reaction time num false alarms0.30.51.7-0.50.7-0.30.20.3-0.2-0.1-0.2-0.7-1.30.7-1.3-1.1
Reaction time num false alarms AUC0.30.72.50.2-0.10.4-0.5-0.4-0.90.5-0.9-1.0-0.91.0-1.6-1.1
Reaction time trials correct on left0.20.71.30.5-0.30.8-0.8-0.8-0.60.9-0.6-1.0-0.51.1-1.1-1.0
Reaction time trials on left0.30.91.60.6-0.40.9-0.9-1.0-0.71.0-0.7-1.2-0.61.3-1.2-1.1
Reaction time mean0.00.00.20.2-0.40.2-0.2-0.20.00.10.20.10.2-0.10.40.1
Reaction time mean AUC0.00.10.40.1-0.30.1-0.0-0.10.20.00.30.30.3-0.20.60.3
Median of all reaction times0.20.30.5-0.40.3-0.50.50.50.6-0.50.60.60.0-0.50.70.5
Reaction time omissions1.42.23.81.9-2.01.9-1.9-1.9-1.41.8-1.3-1.30.61.2-0.6-0.6
Reaction time false alarm rate0.10.20.7-0.40.3-0.30.20.3-0.2-0.1-0.3-0.3-0.80.3-0.9-0.6
Reaction time premature initiation rate2.23.56.32.0-2.01.8-1.9-1.8-2.51.9-2.5-1.70.31.5-2.0-1.3
Reaction time premature initiations2.06.08.72.4-2.32.5-2.6-2.5-3.02.6-2.9-2.50.02.3-2.7-1.9
Std. dev. reaction times0.30.92.01.3-1.41.2-1.2-1.2-0.81.1-0.7-0.50.70.60.1-0.2
Reaction time trials completed0.30.91.60.6-0.40.9-0.9-1.0-0.71.0-0.7-1.2-0.61.3-1.2-1.1
Reaction time trials AUC0.20.61.40.4-0.20.7-0.7-0.8-0.60.8-0.6-1.0-0.61.1-1.2-0.9
Run reversals in cocaine runway, females0.40.42.00.6-0.50.2-0.2-0.1-1.40.1-1.4-0.10.7-0.4-0.50.1
Run reversals in cocaine runway, males0.91.04.6-0.40.50.1-0.2-0.20.30.40.4-1.3-2.21.4-1.3-1.4
Latency to leave start box in cocaine runway0.60.82.7-0.20.2-0.50.50.50.7-0.60.51.21.1-1.21.41.7
Latency to leave start box in cocaine runway, F0.30.41.1-0.10.2-0.40.40.40.5-0.50.30.80.8-0.90.91.0
Latency to leave start box in cocaine runway, M0.20.20.80.3-0.30.2-0.2-0.20.20.1-0.00.40.7-0.20.50.9
Std. dev. time between licks in bursts0.40.82.9-0.10.30.0-0.2-0.1-0.70.2-0.7-1.1-1.40.9-1.7-1.5
Total sessions with >9 infusions0.40.51.80.2-0.3-0.20.30.3-0.2-0.4-0.41.01.3-1.00.90.9
Short access day 1 total inactive lever presses1.12.23.2-1.81.7-1.81.81.81.7-1.71.61.2-0.4-1.21.00.6
Short access day 10 total inactive lever presses0.00.20.4-0.60.2-0.50.50.50.5-0.50.5-0.0-0.6-0.20.10.3
Short access day 1 total infusions1.22.33.3-1.41.2-1.71.71.71.5-1.81.31.60.6-1.81.61.4
Short access day 10 total infusions1.52.55.7-0.30.1-1.01.11.10.6-1.30.32.32.3-2.32.42.4
Short access total infusions0.81.12.6-0.40.1-0.90.91.00.4-1.10.31.51.3-1.61.51.3
Short access day 1 locomotion1.11.83.1-1.10.8-1.41.41.41.3-1.41.11.70.5-1.61.51.7
Short access day 10 total locomotion0.41.72.9-1.00.8-1.31.41.31.0-1.40.81.70.7-1.71.61.7
Short access total locomotion1.42.03.7-1.10.9-1.41.51.51.3-1.51.01.90.7-1.71.71.8
One hour access (0.3 mA shock)4.75.67.8-2.72.3-2.72.82.72.8-2.72.52.3-0.9-2.01.91.6
Compulsive drug intake2.43.56.91.4-1.11.6-1.7-1.6-2.21.8-2.1-2.3-1.02.0-2.6-2.0
One hour access (shock baseline)3.08.012.7-3.02.5-3.03.13.03.6-3.03.33.0-0.3-2.52.92.2
Social response proportion0.40.51.30.9-1.00.8-0.7-0.7-0.60.6-0.60.51.1-0.00.30.7
Social responses0.20.30.40.6-0.60.6-0.6-0.6-0.60.6-0.6-0.30.00.5-0.5-0.2
Social time0.30.50.80.7-0.60.7-0.7-0.7-0.80.8-0.8-0.7-0.20.7-0.8-0.9
Soleus weight2.98.515.7-4.04.0-3.63.43.53.2-3.33.21.4-2.7-1.50.70.0
Bone: stiffness1.22.27.32.0-1.91.5-1.4-1.4-1.21.2-1.30.32.7-0.30.81.2
Tibialis anterior weight9.532.845.26.3-6.36.7-6.7-6.7-6.06.7-6.0-5.61.15.4-4.5-3.7
Time to tail flick, vehicle, before self-admin0.10.20.60.4-0.30.1-0.1-0.1-0.50.1-0.40.20.8-0.40.20.7
Time to tail flick, vehicle, after self-admin0.20.51.60.7-0.80.1-0.2-0.1-1.00.0-1.10.51.3-0.80.50.6
Time to tail flick, test, before self-admin1.92.23.9-1.41.3-1.81.81.80.8-1.90.82.00.5-1.91.21.4
Time to tail flick, test, after self-admin0.00.00.10.1-0.10.2-0.2-0.20.20.20.20.10.20.10.30.4
Delta time to tail flick, vehicle, before/after SA0.30.30.80.6-0.70.3-0.3-0.3-0.70.2-0.90.30.8-0.30.20.3
Delta time to tail flick, test, before/after SA2.42.95.81.3-1.32.0-1.9-2.0-0.82.1-0.6-2.3-1.12.4-1.5-1.8
Tibia length0.92.54.31.7-1.82.0-2.0-2.1-1.12.0-1.0-1.20.51.7-0.9-1.5
Ambulatory time before self-admin0.20.62.40.7-0.70.5-0.3-0.40.20.30.10.81.5-0.51.21.3
Ambulatory time after self-admin0.71.13.2-0.50.6-0.60.70.61.2-0.71.01.31.0-1.11.61.8
Bone: tissue strength0.10.10.40.1-0.1-0.10.10.10.1-0.10.10.50.6-0.40.40.5
Total heroin consumption3.33.96.52.6-2.42.5-2.5-2.5-2.02.4-2.1-1.21.41.4-0.8-0.8
Bone: trabecular number0.81.67.31.2-1.30.6-0.4-0.5-0.60.2-0.71.12.7-1.21.61.6
Bone: trabecular spacing0.30.51.9-0.80.9-0.70.60.60.2-0.50.2-0.4-1.40.2-0.8-0.8
Bone: trabecular thickness0.91.22.7-0.50.4-0.90.90.90.7-1.00.71.41.2-1.61.61.6
Bone: trabecular tissue density2.23.97.4-2.72.5-2.22.12.12.6-2.02.60.9-2.1-0.60.4-0.1
Water consumed over 24 hours0.51.01.61.3-1.21.1-1.1-1.1-1.31.0-1.3-0.70.80.6-0.7-0.3
Number of responses in last shaping day0.00.10.2-0.0-0.10.0-0.0-0.00.20.10.3-0.4-0.50.3-0.3-0.2