Bmp5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Bmp5	0.04	0.03	5.3e-03	0.02	0.02	0	0.01	1.3e-03	3.4e-03	1.2e-01	9.0e-03
2	NAcc	gene expression	Bmp5	0.09	0.04	3.0e-12	0.08	0.09	0.09	0.11	8.3e-10	5.1e-11	1.2e-10	3.2e-12
3	Liver	mRNA stability	Bmp5	0.11	0.05	9.6e-09	0.02	0.06	0.05	0.04	3.6e-03	8.5e-07	3.4e-06	3.5e-05
4	Brain	gene expression	Bmp5	0.14	0.07	3.3e-12	0.1	0.14	0.14	0.14	3.4e-09	1.1e-12	8.0e-13	5.0e-13
5	pVTA	gene expression	Bmp5	0.48	0.12	3.3e-16	0.19	0.33	0.33	0.33	1.4e-08	8.4e-15	7.8e-15	6.0e-15
6	RMTg	gene expression	Bmp5	0.16	0.1	1.8e-03	0.15	0.1	0.15	0.15	6.7e-05	9.8e-04	7.3e-05	7.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.1	0.2	0.3	-0.2	0.3	0.2	0.5	0.5	-0.6
Area under the delay curve	1.0	1.0	2.5	-1.6	1.3	-0.9	0.9	0.3	-0.3
BMI with tail	1.0	3.3	7.6	-2.3	2.0	-2.8	0.6	-1.2	1.2
BMI without tail	0.3	0.7	2.5	-1.6	0.8	0.1	0.7	0.3	0.5
Body weight	0.8	3.5	6.5	-2.3	1.7	-2.5	0.4	-1.6	2.0
Weight adjusted by age	1.8	2.1	4.1	-2.0	1.8	-1.0	1.4	1.2	-0.8
Bone surface	1.9	3.3	5.0	-2.1	2.1	-0.7	2.2	1.7	-1.7
Bone volume	0.8	1.3	2.0	-1.4	1.4	-0.7	1.4	0.8	-0.9
Breakpoint value in progressive ratio session	1.1	1.2	1.8	-1.3	1.3	-0.7	1.2	0.9	-1.0
Number of licking bursts	2.1	2.5	3.8	-2.0	2.0	-1.1	1.8	1.2	-1.1
Context. condit. distance diff. score	0.4	0.5	1.1	-0.5	1.0	-1.0	0.6	0.4	-0.6
Locomotion velocity, session 1	0.1	0.1	0.5	-0.7	0.5	-0.1	0.3	0.0	0.2
Locomotion distance, session 1	0.7	0.9	3.0	-0.1	-0.3	1.7	0.6	1.2	-0.6
Locomotion velocity, session 2	0.7	0.9	2.1	-1.5	0.8	0.1	1.0	0.9	-0.6
Locomotion distance, session 2	0.6	0.9	3.0	-0.8	-0.2	1.7	0.7	1.1	-0.2
Locomotion velocity, session 3	3.1	3.6	7.4	-0.9	0.8	1.6	2.0	2.7	-2.6
Locomotion distance, session 3	2.1	2.3	6.3	0.6	-0.8	2.5	0.7	1.8	-1.6
Stereotopy head waving bouts, day 3	0.3	0.3	0.8	0.5	0.4	-0.9	0.0	0.0	-0.7
Stereotopy head waving duration, day 3	0.5	0.6	2.5	0.4	0.6	-1.6	-0.2	-0.7	-0.1
Locomotion velocity, session 7	0.2	0.3	0.7	-0.0	0.1	0.6	0.4	0.8	-0.6
Locomotion distance, session 7	0.6	0.7	1.5	-0.6	0.5	0.5	0.9	1.2	-1.0
Stereotopy head waving bouts, day 7	1.6	1.8	3.5	-0.7	0.9	0.7	1.5	1.8	-1.9
Stereotopy head waving duration, day 7	1.7	2.1	3.6	-1.0	1.0	0.6	1.7	1.9	-1.9
Locomotion velocity, session 8	1.8	2.1	3.6	-1.4	1.0	1.0	1.7	1.9	-1.5
Locomotion distance, session 8	1.4	2.1	3.9	-1.4	1.0	0.8	1.7	2.0	-1.5
Degree of sensitization distance	1.1	1.1	3.6	-0.8	1.0	-1.9	-0.0	-0.8	0.7
Degree of sensitization stereotypy	1.6	1.8	3.2	-0.9	0.9	0.8	1.5	1.8	-1.7
Conditioned locomotion	1.0	1.2	2.3	0.8	-1.0	0.2	-1.3	-1.2	1.5
Cocaine response after cond. corrected	1.1	1.2	3.3	-1.1	1.5	-1.8	0.6	-0.3	-0.1
Cocaine response after cond. not corrected	1.8	2.0	7.1	-1.0	1.6	-2.7	0.3	-1.0	0.4
Cocaine response before conditioning	0.7	0.9	2.5	-0.8	0.9	-1.6	0.1	-0.8	0.8
Saline control response	0.2	0.3	0.6	0.7	0.2	-0.7	0.1	0.1	-0.7
Bone: connectivity density	0.7	1.1	2.8	0.3	-0.5	1.7	0.6	1.3	-1.2
Bone: cortical apparent density	2.7	3.6	5.1	2.2	-2.3	1.0	-2.1	-1.6	1.8
Bone: cortical area	0.4	0.6	2.5	0.2	0.6	-1.6	-0.2	-0.6	0.1
Bone: cortical porosity	0.2	0.2	0.4	0.6	-0.5	-0.3	-0.6	-0.5	0.2
Bone: cortical porosity	0.1	0.1	0.4	0.7	-0.5	0.1	-0.3	-0.0	-0.3
Bone: cortical thickness	1.7	2.9	5.2	2.3	-1.6	-0.2	-2.0	-1.8	1.4
Bone: cortical thickness	1.8	2.1	3.7	1.5	-0.9	-1.0	-1.7	-1.9	1.4
Bone: cortical tissue density	2.5	3.3	4.7	2.1	-2.2	1.0	-2.1	-1.6	1.7
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	-1.1	0.1	1.1	0.5	0.6	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.7	0.1	0.2	-0.8	-0.4	-0.7	0.4
Condit. Reinf. active responses	1.6	2.0	3.9	-2.0	0.6	1.6	1.4	1.6	-0.9
Condit. Reinf. inactive responses	2.2	2.6	4.2	-1.9	0.6	1.7	1.6	2.1	-1.3
Incentive salience index mean	1.1	1.3	3.3	-1.8	1.0	0.2	1.3	1.1	-0.8
Condit. Reinf. lever presses	1.8	2.4	4.1	-2.0	1.6	-0.8	1.7	1.3	-1.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.5	-1.0	1.2	-0.7	1.0	0.5	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.1	0.7	-0.6	0.5	0.3	-0.4
Condit. Reinf. active responses	0.7	0.9	1.9	-1.4	1.4	-1.0	0.9	0.1	0.1
Condit. Reinf. inactive responses	0.4	0.5	1.5	-1.2	0.8	-0.6	0.4	-0.2	0.6
Condit. Reinf. lever presses	1.2	1.6	4.4	-1.0	1.7	-2.1	1.1	0.2	-0.4
Condit. Reinf. lever reinforcers received	0.5	0.8	1.4	-1.2	1.2	-1.1	0.7	-0.2	0.3
Conditioned reinforcement - actives	0.0	0.0	0.2	-0.1	-0.1	-0.2	0.2	-0.1	-0.4
Conditioned reinforcement - inactives	0.2	0.2	0.5	0.3	-0.4	0.3	-0.4	-0.7	0.7
Conditioned locomotion	1.3	1.6	2.6	1.3	-1.0	-0.6	-1.6	-1.6	1.1
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.3	0.6	-0.3	0.3	0.2	-0.2
Patch foraging indifference point AUC	0.6	0.6	1.5	0.4	-1.2	1.0	-0.6	-0.3	0.9
Delay disc. indifference point, 0s delay	0.6	0.6	1.9	-0.7	0.0	1.4	0.6	1.0	-0.3
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	-0.0	0.2	-0.6	-0.1	-0.4	0.1
Delay disc. indifference point, 2s delay	0.2	0.2	0.6	-0.8	0.5	-0.3	0.2	-0.2	0.2
Delay disc. indifference point, 24s delay	0.0	0.0	0.2	-0.4	0.2	-0.0	0.1	0.0	0.0
Delay disc. indifference point, 4s delay	1.2	1.3	2.5	-1.6	1.2	-0.2	1.3	0.9	-1.0
Delay disc. indifference point, 8s delay	2.0	2.0	4.6	-2.2	1.9	-1.2	1.4	0.6	-0.3
Indifference point function ln k	0.7	1.0	1.8	-0.7	1.3	-0.9	1.0	0.7	-1.3
Indifference point function log k	0.7	1.0	1.8	-0.7	1.3	-0.9	1.0	0.7	-1.3
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.1	0.4	-0.5	-0.0	-0.2	0.2
Patch foraging total patch changes 12 sec	0.6	0.7	1.3	0.8	-1.1	0.8	-0.8	-0.4	1.0
Patch foraging total patch changes 18 sec	0.4	0.5	1.0	0.7	-0.6	-0.4	-0.6	-0.8	1.0
Patch foraging total patch changes 24 sec	0.4	0.5	2.5	-0.0	-0.7	1.6	-0.2	0.2	0.3
Patch foraging total patch changes 6 sec	0.4	0.6	2.7	-0.0	-0.6	1.6	0.2	0.9	-0.1
Patch foraging time to switch 0 sec	0.1	0.2	0.5	0.7	-0.5	0.6	-0.1	0.3	-0.4
Patch foraging water rate 0 sec	0.4	0.7	1.7	-1.0	1.1	-1.3	0.2	-0.4	0.5
Patch foraging water rate 12 sec	0.9	1.3	2.6	-1.6	1.6	-0.6	1.3	0.9	-0.3
Patch foraging water rate 18 sec	0.4	0.6	1.0	0.5	-0.6	0.6	-1.0	-0.9	0.9
Patch foraging water rate 24 sec	0.1	0.1	0.4	-0.0	-0.1	0.6	0.0	0.2	-0.1
Patch foraging water rate 6 sec	1.1	1.7	3.1	-1.8	1.6	-0.6	1.4	0.9	-1.2
Seeking ratio, delayed vs. immediate footshock	5.0	5.7	8.5	-2.9	2.7	-1.0	2.7	2.3	-2.2
Distance traveled before self-admin	2.0	2.1	2.9	-1.2	1.6	-0.7	1.7	1.6	-1.6
Distance traveled after self-admin	2.3	2.6	4.3	-1.9	2.1	-1.8	1.6	0.6	-1.1
Extensor digitorum longus weight	0.7	2.6	6.8	-2.6	1.8	-0.2	1.8	1.3	-0.6
Bone: elastic displacement	0.6	0.7	1.3	0.6	-0.9	0.4	-0.9	-0.8	1.1
Bone: elastic work	0.3	0.4	0.6	0.6	-0.6	0.1	-0.8	-0.7	0.8
Bone: endosteal estimation	3.5	7.6	12.8	-3.4	3.6	-2.3	3.0	1.8	-1.9
Bone: endosteal perimeter	1.9	3.9	6.7	-2.5	2.6	-1.8	2.1	1.2	-1.3
Epididymis fat weight	3.1	7.2	10.9	2.5	-3.3	2.6	-2.7	-1.8	3.1
Delta time in closed arm before/after self-admin	1.8	1.7	3.1	1.2	-1.1	-0.3	-1.8	-1.5	1.4
Delta time in open arm before/after self-admin	1.3	1.2	2.7	0.8	-0.5	1.5	0.6	1.1	-1.6
Diff in mean of infusions in LGA sessions	2.4	2.6	4.9	-1.5	2.2	-2.2	1.6	0.6	-1.0
Delay discount exponential model param	1.2	1.2	3.0	1.7	-1.4	0.9	-1.1	-0.4	0.4
Extinction: sum of active levers before priming	0.3	0.3	0.6	0.0	0.5	-0.3	0.6	0.7	-0.8
Active lever presses in extinction session 6	0.9	0.9	1.3	-1.0	1.1	-0.3	1.2	0.8	-1.1
Bone: final force	0.2	0.3	0.7	-0.6	0.7	-0.9	0.2	-0.3	0.1
Bone: final moment	0.2	0.3	0.9	-0.2	0.3	-1.0	-0.2	-0.7	0.5
Food consumed during 24 hour testing period	3.4	4.1	12.5	-1.9	2.6	-3.5	1.0	-0.7	-0.2
Glucose	0.1	0.2	0.4	0.7	-0.6	0.5	-0.3	-0.1	-0.1
Heart weight	0.4	0.6	2.5	0.1	-0.4	0.1	-0.4	-0.8	1.6
Delay discount hyperbolic model param	1.0	1.1	2.6	1.6	-1.4	0.9	-1.0	-0.4	0.4
Intermittent access intake day 1-15 change	0.2	0.2	0.7	-0.1	0.0	-0.3	0.2	-0.8	0.6
Intermittent access intake escalation	0.5	0.5	0.8	-0.8	0.8	-0.9	0.7	-0.5	0.2
Intermittent access intake escalation 2	1.0	1.0	1.9	-1.3	1.3	-0.9	1.4	0.3	-0.4
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.3	0.6	-0.2	0.2	-0.3	-0.0	-0.3
Intermitt. access day 15 inactive lever presses	1.2	1.3	2.1	1.1	-1.3	0.6	-1.4	-1.2	0.8
Intermitt. access escalation Index	2.9	2.5	7.8	-0.9	1.1	-2.8	0.1	-1.5	1.8
Intermittent access day 1 total infusions	1.3	1.5	3.0	1.7	-1.4	0.2	-1.6	-1.0	0.7
Intermittent access day 15 total infusions	0.4	0.5	1.1	0.7	-0.5	-0.6	-0.6	-1.1	0.7
Intermittent access terminal intake (last 3 days)	0.4	0.4	1.2	0.3	0.0	-1.1	-0.4	-0.9	0.6
Intermittent access total infusions	0.5	0.5	1.3	1.1	-0.5	-0.7	-0.7	-0.8	0.2
Intermittent access day 1 locomotion	2.1	2.3	4.3	1.8	-1.8	0.4	-2.1	-1.2	1.1
Intermittent access day 15 total locomotion	0.6	0.6	1.4	1.2	-0.8	0.1	-1.1	-0.6	0.1
Intermittent access total locomotion	0.2	0.2	0.5	0.7	-0.2	-0.3	-0.6	-0.2	-0.5
Intermittent access standard deviation	0.1	0.1	0.2	0.0	0.3	-0.4	0.3	-0.1	-0.3
Left kidney weight	0.3	0.7	2.3	-0.5	0.3	-1.0	-0.2	-0.9	1.5
Right kidney weight	0.1	0.3	0.5	-0.7	0.6	-0.5	0.4	-0.1	0.5
Cocaine induced anxiety	0.4	0.4	0.9	-0.3	0.1	0.6	0.5	0.9	-0.9
Post-drug Anxiety	1.1	1.2	4.2	0.7	-0.9	2.1	0.1	1.1	-0.9
Baseline Anxiety	1.5	1.6	2.3	1.4	-1.5	1.4	-1.3	-0.7	0.9
Tail length	0.2	0.7	1.7	-1.0	0.1	1.3	0.7	1.0	-0.0
Length with tail	0.1	0.4	1.2	-1.1	0.6	-0.3	0.4	-0.2	0.7
Length without tail	1.1	2.4	8.8	-0.8	1.3	-3.0	-0.1	-1.6	0.9
Times rat made contact with spout	1.2	1.4	4.4	-1.1	1.5	-2.1	0.5	-0.3	-0.0
Lifetime Intake	0.8	0.9	2.3	1.5	-1.0	-0.2	-1.1	-0.9	0.4
Liver weight, left	0.2	0.3	1.0	-0.5	0.3	-1.0	-0.2	-0.6	0.5
Liver weight, right	0.2	0.4	1.6	-0.5	-0.1	-0.0	-0.3	-0.6	1.3
Locomotor activity	0.2	0.4	1.2	-0.2	0.3	-0.8	-0.1	-0.5	1.1
Locomotor testing distance	0.1	0.2	0.8	-0.0	0.2	-0.6	-0.3	-0.4	0.9
Locomotor testing rearing	0.0	0.1	0.3	0.2	0.0	-0.0	-0.4	-0.2	0.5
Locomotion in novel chamber	0.2	0.2	0.5	0.6	-0.4	-0.1	-0.7	-0.3	0.0
Locomotion in novel chamber post-restriction	0.3	0.4	0.5	0.7	-0.7	0.3	-0.7	-0.7	0.5
Fecal boli incidents, locomotor time 1	0.6	0.6	1.5	-1.2	1.0	-1.0	0.6	-0.2	0.3
Change in fecal boli incidents, locomotor task	0.8	0.8	2.2	-0.0	0.7	-0.5	0.9	0.9	-1.5
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.1	-0.8	1.0	-0.6	1.0	0.9	-0.8
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.6	0.4	-0.0	0.1	-0.1	0.3
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.5	0.4	-0.3	0.1	-0.3	0.3
Rest time, locomotor task time 1	0.7	0.8	2.6	-0.2	0.5	-1.6	-0.5	-1.0	0.8
Distance moved, locomotor task time 1	0.6	0.6	2.6	0.5	-0.9	1.6	-0.1	0.4	0.2
Vertical activity count, locomotor time 1	0.3	0.3	1.1	0.5	-0.5	1.1	0.1	0.3	-0.1
Time >=10cm from walls, locomotor time 2	0.7	0.7	1.2	0.6	-0.3	-0.9	-0.8	-1.0	1.1
Bouts of movement, locomotor time 2	0.7	0.7	1.4	0.4	-1.2	1.2	-0.8	-0.4	0.9
Total resting periods, locomotor time 2	0.4	0.5	0.8	0.3	-0.9	0.9	-0.7	-0.3	0.7
Rest time, locomotor task time 2	1.3	1.4	2.2	1.5	-1.1	-0.2	-1.5	-1.3	1.2
Distance moved, locomotor task time 2	0.6	0.7	1.6	-0.8	0.2	1.3	0.8	1.1	-0.6
Vertical activity count, locomotor time 2	0.0	0.1	0.1	-0.3	0.2	0.0	0.4	0.1	0.1
Light reinforcement 1	0.8	1.4	4.2	-2.0	1.1	-1.1	0.5	-0.5	1.0
Light reinforcement 2	0.4	0.6	2.2	0.5	0.0	-1.5	-0.4	-0.8	0.3
Bone: marrow area	3.4	7.4	12.7	-3.3	3.6	-2.4	2.9	1.7	-1.8
Bone: maximum diameter	3.7	6.9	13.0	-3.0	3.6	-3.3	2.4	0.9	-1.3
Bone: maximum force	0.4	0.8	1.6	-1.1	1.2	-1.2	0.6	-0.1	-0.1
Bone: maximum moment	0.3	0.6	1.8	-0.7	0.9	-1.3	0.2	-0.5	0.2
Mean time between licks in bursts	0.2	0.2	0.4	0.5	-0.4	-0.2	-0.5	-0.6	0.6
Mean num. licks in bursts	1.3	1.6	2.6	1.2	-1.0	-0.3	-1.6	-1.6	1.3
Cd content in liver	0.3	0.3	0.8	-0.8	0.2	0.9	0.5	0.6	-0.2
Co content in liver	1.1	1.3	3.1	0.4	-1.0	0.2	-1.2	-1.5	1.8
Cu content in liver	1.1	1.3	2.1	1.0	-1.1	0.1	-1.4	-1.3	1.5
Fe content in liver	2.8	3.4	6.2	-1.0	1.2	0.9	2.2	2.4	-2.5
K content in liver	0.1	0.1	0.4	-0.1	0.1	0.2	0.3	0.4	-0.6
Mg content in liver	0.3	0.3	0.9	-1.0	0.8	-0.4	0.6	0.1	-0.2
Mn content in liver	0.7	0.8	2.2	0.9	-0.1	-1.5	-0.7	-1.1	0.0
Na content in liver	1.4	1.5	3.3	-0.6	0.8	0.1	1.3	1.6	-1.8
Rb content in liver	1.0	1.3	2.1	-1.4	1.1	0.4	1.3	1.3	-1.0
Se content in liver	0.4	0.5	1.7	1.3	-0.9	0.5	-0.6	-0.1	-0.3
Sr content in liver	0.4	0.3	0.7	-0.8	0.6	-0.1	0.7	0.6	-0.4
Zn content in liver	0.9	1.0	1.9	0.7	-0.7	-0.4	-1.2	-1.3	1.4
Bone: minimum diameter	0.4	0.7	2.3	-0.1	0.5	-1.5	-0.4	-1.0	0.7
Time in familiar zone, hab. session 1	1.6	1.5	2.5	-1.5	1.6	-1.0	1.4	0.9	-0.8
Time in novel zone, hab. session 1	2.2	2.2	3.1	1.5	-1.5	0.2	-1.8	-1.7	1.5
Total zone transitions, hab. session 1	1.1	1.6	6.9	0.4	-1.3	2.6	-0.0	0.8	0.0
Total locomotion distance, hab. session 1	1.7	2.5	10.2	0.8	-1.8	3.2	-0.4	0.7	0.4
Locomotion velocity, hab. session 1	1.1	1.6	7.0	0.5	-1.3	2.7	-0.0	0.9	0.0
Time in familiar zone, hab. session 2	0.1	0.2	0.3	-0.4	0.6	-0.4	0.3	0.2	-0.3
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.3	-0.5	0.3
Total zone transitions, hab. session 2	1.2	1.5	6.5	-0.6	-0.7	2.5	0.5	1.2	-0.3
Total locomotion distance, hab. session 2	1.2	1.6	7.4	-0.3	-1.1	2.7	0.1	0.9	0.1
Locomotion velocity, hab. session 2	1.1	1.5	6.7	-0.0	-1.3	2.6	-0.1	0.7	0.2
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.5	0.5	-0.7	0.3	-0.3	0.3
Novelty place preference	0.5	0.6	1.6	-0.8	0.8	-1.2	0.4	-0.4	0.3
Time in novel zone, NPP test	0.9	0.9	2.8	-0.9	1.2	-1.7	0.5	-0.4	0.3
Total zone transitions, NPP test	0.7	1.0	3.2	-0.7	-0.1	1.8	0.7	1.3	-0.6
Total locomotion distance, NPP test	1.0	1.3	4.7	-0.8	-0.3	2.2	0.7	1.3	-0.4
Locomotion velocity, NPP test	1.4	2.0	7.6	-0.5	-0.7	2.8	0.7	1.6	-0.6
Intraocular pressure	0.1	0.2	0.5	0.1	-0.2	-0.0	-0.3	-0.6	0.7
Delta distance traveled before/after self-admin	0.7	0.8	1.8	-0.6	0.4	-1.4	-0.3	-1.3	0.8
Delta ambulatory time before/after self-admin	0.9	1.0	2.8	-0.5	0.4	-1.7	-0.4	-1.4	0.7
Parametrial fat weight	0.1	0.2	0.8	0.0	-0.4	0.9	0.0	0.4	0.1
Pavlov. Cond. lever latency	2.2	2.7	4.3	2.1	-1.6	0.2	-2.0	-1.8	1.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.2	-0.4	-0.1	0.1	0.1	0.2	-0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.5	-0.7	0.2	0.1	0.3	0.4	-0.3
Pavlov. Cond. index score	0.6	0.7	1.3	-1.1	0.5	0.3	0.9	1.0	-0.9
Pavlov. Cond. latency score	0.7	0.9	1.5	-1.2	0.6	0.2	1.0	1.1	-1.0
Pavlov. Cond. lever contacts	1.0	1.2	2.4	-1.5	1.1	-0.2	1.3	1.1	-1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.3	0.2	-0.6	-0.1	-0.5	0.4
Pavlov. Cond. intertrial magazine entries	1.5	1.8	3.1	-1.2	0.5	1.6	1.4	1.8	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.5	-1.2	0.6	0.3	1.0	1.1	-1.1
Pavlov. Cond. response bias	0.2	0.3	0.7	-0.8	0.3	0.3	0.5	0.6	-0.6
Pavlov. Cond. lever latency	1.9	2.5	4.2	1.9	-2.0	1.4	-1.8	-1.0	0.9
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.8	-0.4	0.5	0.1	0.7	-0.8
Pavlov. Cond. change in total contacts	0.3	0.5	0.8	-0.9	0.9	-0.6	0.8	0.5	-0.2
Pavlov. Cond. index score	1.0	1.3	2.0	-1.1	1.3	-0.7	1.4	1.1	-1.0
Pavlov. Cond. latency score	1.3	1.6	2.3	-1.2	1.5	-1.0	1.5	1.2	-1.2
Pavlov. Cond. lever contacts	2.0	2.7	4.5	-2.0	2.1	-1.7	1.8	0.9	-0.8
Pavlov. Cond. magazine entry number	0.5	0.6	1.4	0.1	-0.4	-0.3	-0.8	-1.2	1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.2	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.6	-0.9	1.1	-0.6	1.3	1.0	-0.9
Pavlov. Cond. response bias	0.9	1.2	1.9	-1.2	1.2	-0.4	1.4	1.2	-0.9
Time in closed arm before self-admin	0.6	0.7	1.2	-1.1	1.0	-0.7	1.1	0.5	-0.5
Time in closed arm after self-admin	0.5	0.5	1.1	0.5	-0.6	-0.1	-0.9	-0.8	1.1
Time in open arm before self-admin	0.7	0.8	2.5	-0.9	1.1	-1.6	0.3	-0.0	-0.3
Time in open arm after self-admin	1.3	1.4	4.2	-0.5	0.9	-0.2	1.3	1.3	-2.1
Bone: periosteal estimation	2.0	4.1	7.8	-2.4	2.8	-2.4	1.9	0.8	-1.1
Bone: periosteal perimeter	1.2	2.0	3.4	-1.5	1.9	-1.3	1.5	1.0	-1.2
Bone: post-yield work	2.9	3.9	7.2	-2.7	2.4	-1.2	2.2	1.4	-1.3
Progressive ratio test 1 active lever presses	0.5	0.5	0.9	0.5	-0.2	-1.0	-0.6	-0.9	0.8
Progressive ratio test 1 breakpoint	0.5	0.5	1.3	0.6	-0.1	-1.1	-0.6	-0.8	0.7
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.8	0.9	-0.6	-0.2	-0.6	-0.6	0.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	0.5	-0.5	-0.3	-0.4	-0.6	0.3
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.2	-0.4	0.1
Progressive ratio test 2 inactive lever presses	0.9	1.0	2.6	1.6	-1.1	0.1	-1.2	-0.8	0.2
Incentive Sensitization - Responses	0.1	0.1	0.4	0.4	-0.6	0.1	-0.3	-0.3	0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.7	0.5	-0.8	0.4	-0.5	-0.4	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.3	0.7	-0.7	0.4	-0.0	-0.4
Progressive ratio	0.4	0.5	1.1	-0.7	0.6	-1.0	-0.0	-0.5	1.0
Food seeking constrained by brief footshock	2.5	3.1	5.8	-2.4	2.3	-1.6	1.8	0.8	-1.0
Seeking ratio, punishment vs. effort	1.0	1.2	2.7	-1.0	0.8	0.2	1.2	1.1	-1.6
Retroperitoneal fat weight	1.0	3.4	5.3	1.4	-2.2	1.7	-1.9	-1.5	2.3
Reaction time number correct	0.9	1.3	2.0	-0.9	0.7	0.6	1.4	1.4	-1.4
Reaction time mean minus median	1.5	2.0	3.1	1.8	-1.5	0.3	-1.5	-1.6	1.4
Reaction time mean minus median AUC	1.0	1.2	2.5	1.6	-1.2	0.2	-1.1	-1.2	0.8
Reaction time num false alarms	0.6	0.8	1.7	1.3	-1.0	1.3	-0.6	0.2	-0.1
Reaction time num false alarms AUC	0.7	0.9	2.2	1.3	-1.1	1.5	-0.6	0.3	-0.4
Reaction time trials correct on left	0.9	1.3	2.0	-0.9	0.7	0.6	1.4	1.4	-1.4
Reaction time trials on left	0.9	1.3	2.0	-0.9	0.6	0.8	1.3	1.4	-1.4
Reaction time mean	1.0	1.4	2.9	1.7	-1.1	-0.1	-1.2	-1.2	1.1
Reaction time mean AUC	0.6	0.8	2.1	1.4	-0.9	-0.1	-0.9	-0.9	0.7
Median of all reaction times	0.8	1.0	2.7	1.6	-1.1	-0.1	-1.0	-0.9	0.8
Reaction time omissions	1.0	1.4	4.3	1.2	-1.4	2.1	-0.5	0.4	0.1
Reaction time false alarm rate	1.1	1.5	3.0	1.7	-1.4	1.0	-1.4	-0.7	0.6
Reaction time premature initiation rate	0.2	0.3	1.2	-0.3	-0.1	-0.1	-0.2	-0.7	1.1
Reaction time premature initiations	0.1	0.1	0.4	-0.7	0.2	0.3	0.5	-0.0	0.3
Std. dev. reaction times	1.5	2.0	3.8	2.0	-1.6	0.6	-1.4	-1.3	1.3
Reaction time trials completed	0.9	1.3	2.0	-0.9	0.6	0.8	1.3	1.4	-1.4
Reaction time trials AUC	1.0	1.4	2.3	-0.9	0.7	0.7	1.5	1.5	-1.5
Run reversals in cocaine runway, females	1.3	1.2	2.1	1.3	-1.0	-0.0	-1.5	-1.2	1.1
Run reversals in cocaine runway, males	1.6	1.5	2.4	-1.4	1.0	0.5	1.4	1.6	-1.3
Latency to leave start box in cocaine runway	0.6	0.6	1.5	-0.5	0.5	0.0	0.9	0.9	-1.2
Latency to leave start box in cocaine runway, F	0.2	0.3	0.5	-0.7	0.4	0.0	0.6	0.4	-0.6
Latency to leave start box in cocaine runway, M	0.5	0.5	1.1	0.7	-0.3	0.8	0.2	0.8	-1.1
Std. dev. time between licks in bursts	1.2	1.5	2.3	-1.5	1.1	0.2	1.5	1.3	-1.2
Total sessions with >9 infusions	0.2	0.2	0.8	0.0	0.4	-0.9	0.1	0.1	-0.3
Short access day 1 total inactive lever presses	0.6	0.7	1.3	0.7	-0.5	-0.6	-0.9	-1.1	1.1
Short access day 10 total inactive lever presses	0.1	0.1	0.3	0.6	-0.1	0.4	0.1	0.1	-0.0
Short access day 1 total infusions	0.2	0.3	0.8	0.9	-0.5	-0.2	-0.5	-0.3	0.2
Short access day 10 total infusions	0.3	0.4	1.3	1.1	-0.4	-0.5	-0.5	-0.0	-0.6
Short access total infusions	1.7	1.9	4.5	2.1	-1.6	0.1	-1.6	-1.0	0.7
Short access day 1 locomotion	0.2	0.3	0.4	-0.6	0.6	-0.7	0.4	0.2	-0.4
Short access day 10 total locomotion	0.4	0.4	1.5	-0.3	0.6	-0.3	0.3	0.6	-1.2
Short access total locomotion	0.2	0.3	0.6	0.7	-0.3	-0.5	-0.8	-0.3	-0.1
One hour access (0.3 mA shock)	0.3	0.3	0.7	0.8	-0.7	0.1	-0.7	-0.5	0.0
Compulsive drug intake	0.4	0.4	1.8	0.5	0.2	-1.3	-0.3	-0.6	0.2
One hour access (shock baseline)	0.1	0.1	0.5	0.1	-0.2	0.3	0.1	0.4	-0.7
Social response proportion	1.4	1.5	2.5	1.4	-0.9	-0.5	-1.5	-1.6	1.2
Social responses	0.1	0.1	0.3	-0.0	-0.1	-0.4	-0.5	-0.5	0.4
Social time	0.0	0.0	0.1	0.2	-0.1	-0.1	0.0	-0.2	-0.0
Soleus weight	5.2	15.3	33.0	-5.7	4.9	-2.2	4.3	2.7	-2.3
Bone: stiffness	0.1	0.2	0.4	-0.6	0.5	0.3	0.5	0.5	-0.5
Tibialis anterior weight	3.1	10.4	17.6	-4.1	4.2	-2.2	3.5	2.3	-2.4
Time to tail flick, vehicle, before self-admin	0.9	0.9	1.9	-0.9	0.8	0.2	1.4	1.1	-1.0
Time to tail flick, vehicle, after self-admin	3.2	3.4	5.0	-1.4	2.2	-1.5	1.8	1.7	-2.2
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.3	0.0	0.2	0.0	0.1	0.1
Time to tail flick, test, after self-admin	0.7	0.7	1.4	-0.9	1.2	-0.7	0.9	0.5	-0.4
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.2	-0.7	1.1	-0.7	0.7	0.8	-1.0
Delta time to tail flick, test, before/after SA	0.9	0.8	1.7	-0.6	1.3	-1.3	0.9	0.4	-0.5
Tibia length	1.2	3.3	12.7	-0.4	1.3	-3.6	-0.5	-1.8	1.3
Ambulatory time before self-admin	1.0	1.1	2.1	-0.6	0.9	-0.1	1.2	1.4	-1.4
Ambulatory time after self-admin	1.8	2.0	3.7	-1.5	1.8	-1.9	1.3	0.4	-1.1
Bone: tissue strength	0.4	0.4	0.7	0.8	-0.7	0.2	-0.7	-0.5	0.4
Total heroin consumption	1.4	1.7	2.9	-1.7	1.7	-1.1	1.4	0.6	-0.8
Bone: trabecular number	0.7	1.0	2.1	-0.6	0.4	0.8	1.1	1.5	-1.3
Bone: trabecular spacing	2.3	3.0	4.6	1.8	-2.2	1.3	-2.0	-1.4	1.6
Bone: trabecular thickness	0.6	0.7	1.6	0.4	0.1	-1.3	-0.7	-1.1	0.8
Bone: trabecular tissue density	1.3	1.8	3.3	1.2	-0.7	-0.9	-1.5	-1.8	1.6
Water consumed over 24 hours	1.5	1.8	4.4	-1.6	1.9	-2.1	0.8	-0.1	-0.3
Number of responses in last shaping day	2.2	2.3	7.3	-1.3	1.8	-2.7	0.9	0.1	-0.8