Hub : Genes

Bmal1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Bmal1	0.03	0.02	3.1e-03	0.01	0.02	0.03	0.02	1.6e-02	2.9e-03	1.2e-03	8.1e-03
2	BLA	alternative TSS	XM_039109763.1	0.04	0.03	9.6e-03	0.03	0.01	-0	0.02	7.6e-03	5.2e-02	9.8e-01	4.1e-02
3	BLA	alternative TSS	XM_039109763.1	0.04	0.03	6.5e-03	0.04	0.02	-0	0.02	5.8e-03	3.8e-02	8.4e-01	3.7e-02
4	BLA	gene expression	Bmal1	0.05	0.04	8.8e-03	0.01	0.03	0.02	0.01	1.5e-01	1.4e-02	4.2e-02	1.0e-01
5	BLA	isoform ratio	XM_006230029.4	0.07	0.05	2.8e-03	0.02	0.04	0.02	0.03	3.5e-02	5.3e-03	1.9e-02	1.1e-02
6	Adipose	gene expression	Bmal1	0.1	0.06	3.0e-07	0.02	0.05	0.04	0.04	9.9e-04	4.3e-06	2.9e-05	4.2e-05
7	Adipose	alternative TSS	XM_039109763.1	0.09	0.05	1.4e-06	0.05	0.05	0.04	0.05	1.9e-06	1.2e-06	3.4e-05	1.8e-06
8	Adipose	alternative TSS	XM_039109763.1	0.08	0.04	1.1e-05	0.04	0.05	0.03	0.04	1.8e-05	7.1e-06	2.6e-04	2.4e-05
9	Adipose	intron excision ratio	chr1_167399993_167401894	0.04	0.02	1.0e-03	0	0.01	0.02	0.01	1.9e-01	6.9e-03	5.9e-03	9.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.2	0.4	-0.6	0.7	0.5	-0.4	-0.0	-0.4	-0.4	-0.3	-0.1
Area under the delay curve	0.1	0.1	0.4	-0.5	0.2	0.2	-0.0	-0.1	0.0	-0.2	-0.2	-0.7
BMI with tail	2.1	6.9	14.2	0.0	-2.8	-2.9	3.8	-3.7	-0.1	2.9	2.4	-1.8
BMI without tail	1.9	4.0	8.5	-1.0	-1.8	-2.1	2.7	-2.9	0.0	2.3	2.0	-1.4
Body weight	0.4	1.8	4.2	-0.8	-0.7	-1.1	1.7	-2.0	-1.0	1.2	0.9	-1.8
Weight adjusted by age	0.8	0.9	3.0	0.2	-0.6	0.1	0.5	-0.6	1.4	-1.0	-1.1	-1.7
Bone surface	0.0	0.0	0.1	-0.0	0.3	0.3	-0.2	-0.1	-0.1	-0.2	-0.2	0.1
Bone volume	0.1	0.1	0.6	-0.3	-0.1	-0.2	0.4	-0.8	0.1	0.2	0.1	-0.4
Breakpoint value in progressive ratio session	0.1	0.2	0.6	0.8	-0.1	-0.1	-0.3	0.5	0.3	-0.0	0.0	0.6
Number of licking bursts	1.2	1.4	7.8	2.8	-0.5	0.0	-0.6	1.2	1.2	-0.3	-0.2	1.2
Context. condit. distance diff. score	0.3	0.4	0.8	-0.6	-0.9	-0.7	0.6	-0.5	0.9	0.4	0.5	-0.1
Locomotion velocity, session 1	0.7	0.7	1.5	0.8	-1.1	-1.1	0.8	-0.7	1.2	0.7	0.8	0.1
Locomotion distance, session 1	3.1	4.0	7.4	0.2	-2.6	-2.3	2.7	-2.6	1.5	1.6	1.4	-1.7
Locomotion velocity, session 2	0.4	0.5	0.9	0.8	-0.8	-1.0	0.6	-0.4	0.6	0.7	0.8	0.0
Locomotion distance, session 2	4.1	5.7	10.6	0.4	-2.8	-2.8	3.3	-3.1	1.5	2.1	1.8	-2.2
Locomotion velocity, session 3	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	0.1	0.1	-0.3	-0.4	-0.3
Locomotion distance, session 3	0.2	0.2	0.6	-0.5	0.2	0.6	-0.2	0.3	-0.0	-0.7	-0.8	-0.4
Stereotopy head waving bouts, day 3	0.6	0.7	1.8	1.1	-1.3	-0.4	0.9	-0.5	1.3	-0.1	-0.3	-0.8
Stereotopy head waving duration, day 3	0.3	0.3	0.9	0.8	-0.9	-0.4	0.5	-0.2	1.0	0.1	0.0	-0.3
Locomotion velocity, session 7	0.3	0.3	0.7	-0.8	0.0	-0.6	-0.0	-0.0	-0.1	0.6	0.8	0.8
Locomotion distance, session 7	0.1	0.1	0.6	-0.8	0.4	0.1	-0.5	0.4	-0.1	-0.2	-0.1	0.2
Stereotopy head waving bouts, day 7	0.3	0.4	0.8	0.3	0.3	0.8	-0.6	0.7	0.4	-0.9	-0.9	0.1
Stereotopy head waving duration, day 7	0.1	0.2	0.5	0.3	-0.5	-0.2	0.4	-0.5	0.7	0.1	0.0	-0.4
Locomotion velocity, session 8	0.5	0.6	3.0	0.9	-0.6	0.1	-0.2	0.4	1.7	-0.8	-0.7	-0.1
Locomotion distance, session 8	2.2	3.3	5.6	0.1	-2.3	-2.1	2.4	-2.3	1.5	1.5	1.4	-1.5
Degree of sensitization distance	0.6	0.7	1.4	0.6	-0.8	-1.2	0.7	-0.6	0.8	1.0	1.0	0.1
Degree of sensitization stereotypy	0.2	0.2	0.4	0.3	0.4	0.6	-0.6	0.5	0.3	-0.7	-0.6	0.2
Conditioned locomotion	0.3	0.4	1.9	-1.1	0.5	0.1	-0.1	0.2	-1.4	0.2	0.1	0.1
Cocaine response after cond. corrected	0.1	0.1	0.3	0.1	0.5	0.1	-0.3	0.2	-0.5	0.1	0.1	0.5
Cocaine response after cond. not corrected	0.5	0.5	2.5	-0.0	1.1	0.2	-0.1	-0.2	-1.6	0.6	0.5	0.6
Cocaine response before conditioning	0.5	0.6	2.8	-0.2	0.7	0.0	0.4	-0.7	-1.7	0.9	0.8	0.4
Saline control response	0.2	0.3	0.7	0.7	0.7	0.8	-0.4	0.1	-0.4	-0.4	-0.5	-0.1
Bone: connectivity density	0.1	0.2	0.5	-0.2	0.6	0.2	-0.4	0.1	-0.7	0.2	0.2	0.7
Bone: cortical apparent density	1.2	1.6	3.3	0.7	1.4	1.2	-1.8	1.8	-0.4	-0.9	-0.7	1.5
Bone: cortical area	0.5	0.7	2.3	-0.4	-0.5	-0.8	1.1	-1.5	0.1	0.8	0.6	-0.9
Bone: cortical porosity	1.7	1.9	4.0	-2.0	1.5	1.6	-1.0	0.6	-1.5	-1.4	-1.5	-0.7
Bone: cortical porosity	2.4	2.6	4.1	-1.7	1.8	2.0	-1.6	1.3	-1.5	-1.8	-1.9	-0.2
Bone: cortical thickness	0.6	1.0	2.3	-0.4	-0.8	-1.2	1.3	-1.5	0.2	1.2	1.1	-0.7
Bone: cortical thickness	0.3	0.3	0.7	-0.6	-0.2	-0.7	0.5	-0.7	-0.2	0.8	0.8	0.1
Bone: cortical tissue density	1.2	1.5	3.3	0.7	1.4	1.2	-1.7	1.8	-0.4	-0.9	-0.6	1.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	-0.2	0.1	0.4	0.1	-0.1	-0.3	-0.4	-0.6	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.0	0.5	0.4	-0.2	0.1	-0.4	-0.2	-0.2	-0.1
Condit. Reinf. active responses	0.4	0.5	1.2	-0.4	0.5	0.9	-0.3	0.3	-0.6	-0.9	-1.1	-0.9
Condit. Reinf. inactive responses	0.3	0.4	1.4	-0.9	0.1	0.4	0.3	-0.3	-0.6	-0.4	-0.6	-1.2
Incentive salience index mean	0.4	0.5	1.8	-0.5	1.0	0.7	-0.5	0.3	-1.4	-0.3	-0.4	-0.0
Condit. Reinf. lever presses	1.1	1.5	4.0	-0.6	1.8	1.2	-1.4	1.2	-2.0	-0.7	-0.6	0.7
Condit. Reinf. active minus inactive responses	1.1	1.4	4.0	0.5	-1.4	-0.5	1.2	-1.2	1.6	-0.3	-0.5	-2.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.6	-0.5	-0.2	0.4	-0.5	0.5	-0.1	-0.1	-0.6
Condit. Reinf. active responses	0.9	1.3	4.1	0.6	-1.3	-0.4	1.2	-1.2	1.4	-0.2	-0.4	-2.0
Condit. Reinf. inactive responses	0.2	0.3	1.4	-0.1	-0.4	-0.1	0.7	-0.8	0.3	0.0	-0.1	-1.2
Condit. Reinf. lever presses	1.1	1.5	3.7	0.3	-1.0	-1.0	1.7	-1.9	0.5	0.8	0.6	-1.8
Condit. Reinf. lever reinforcers received	0.6	0.8	2.8	0.7	-0.9	-0.2	0.8	-0.9	1.2	-0.4	-0.5	-1.7
Conditioned reinforcement - actives	6.6	6.6	18.2	-4.3	2.6	2.5	-2.5	2.3	-2.7	-1.9	-1.9	1.3
Conditioned reinforcement - inactives	0.9	1.0	6.2	-2.5	0.1	0.5	-0.5	0.5	-0.5	-1.0	-1.0	-0.1
Conditioned locomotion	6.4	7.7	39.9	-6.3	2.2	2.1	-2.0	1.8	-2.5	-1.7	-1.8	0.9
Patch foraging indifference point 0 sec	0.5	0.8	5.6	2.4	0.1	0.1	-0.4	0.7	0.8	0.2	0.4	0.7
Patch foraging indifference point AUC	0.9	1.1	2.1	1.0	-1.2	-0.9	1.2	-1.4	0.9	0.3	0.1	-1.3
Delay disc. indifference point, 0s delay	0.3	0.4	1.0	1.0	0.3	0.9	-0.1	-0.2	0.1	-0.8	-0.9	-0.2
Delay disc. indifference point, 16s delay	0.3	0.3	0.9	0.5	0.3	0.4	-0.8	0.9	0.4	-0.7	-0.6	0.0
Delay disc. indifference point, 2s delay	0.7	0.7	2.8	-1.4	0.4	0.5	0.2	-0.6	-0.2	-0.6	-0.7	-1.7
Delay disc. indifference point, 24s delay	0.6	0.6	2.2	-1.5	0.8	0.5	-0.6	0.6	-1.3	-0.2	-0.2	-0.2
Delay disc. indifference point, 4s delay	0.6	0.6	2.9	0.0	-0.4	0.1	0.6	-0.8	1.0	-0.5	-0.7	-1.7
Delay disc. indifference point, 8s delay	0.7	0.8	1.2	0.3	-1.1	-1.0	1.1	-0.9	0.5	1.1	1.1	-0.4
Indifference point function ln k	0.6	0.8	1.5	-1.2	1.2	0.5	-1.0	1.0	-1.0	0.0	0.2	1.1
Indifference point function log k	0.6	0.8	1.5	-1.2	1.2	0.5	-1.0	1.0	-1.0	0.0	0.2	1.1
Patch foraging total patch changes 0 sec	0.5	0.8	4.7	2.2	0.2	0.1	-0.5	0.8	0.7	0.1	0.3	0.7
Patch foraging total patch changes 12 sec	0.9	1.2	10.2	3.2	-0.2	0.1	-0.1	0.3	0.7	-0.0	0.0	0.3
Patch foraging total patch changes 18 sec	1.2	1.5	9.8	3.1	0.2	0.4	-0.9	1.2	0.8	-0.6	-0.4	0.7
Patch foraging total patch changes 24 sec	0.3	0.3	2.1	1.5	0.3	0.4	-0.4	0.4	0.2	-0.2	-0.1	0.2
Patch foraging total patch changes 6 sec	1.2	1.8	12.1	3.5	-0.9	-0.3	0.7	-0.4	1.5	0.3	0.3	-0.4
Patch foraging time to switch 0 sec	0.8	1.2	3.4	1.8	1.1	1.1	-1.1	1.4	-0.8	-0.5	-0.4	1.1
Patch foraging water rate 0 sec	0.3	0.5	1.3	-0.1	0.7	0.5	-1.1	1.1	0.1	-0.6	-0.4	0.9
Patch foraging water rate 12 sec	1.8	2.8	5.7	0.8	-1.6	-2.4	1.8	-1.7	0.8	2.2	2.2	-0.3
Patch foraging water rate 18 sec	0.6	0.8	1.8	1.3	-0.3	-1.0	0.4	-0.6	0.4	1.1	1.3	0.5
Patch foraging water rate 24 sec	2.4	3.3	5.9	2.0	-1.9	-2.4	1.5	-1.2	1.1	2.2	2.4	1.0
Patch foraging water rate 6 sec	0.9	1.3	3.4	0.5	1.0	0.5	-1.7	1.7	-0.2	-0.6	-0.3	1.9
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	8.7	-3.0	0.2	-0.1	0.1	-0.1	-1.3	0.6	0.5	0.4
Distance traveled before self-admin	1.9	2.0	4.2	1.3	1.9	1.8	-1.2	1.2	-2.0	-1.0	-1.1	-0.1
Distance traveled after self-admin	1.0	1.1	2.6	1.6	1.4	1.2	-0.7	0.8	-1.4	-0.5	-0.6	0.1
Extensor digitorum longus weight	0.8	3.1	6.1	-0.7	-0.8	-2.1	1.9	-2.5	-0.3	2.5	2.4	-0.4
Bone: elastic displacement	0.1	0.1	0.3	0.5	-0.4	-0.1	0.0	0.4	0.4	-0.1	-0.1	0.2
Bone: elastic work	0.3	0.4	0.7	0.2	-0.8	-0.8	0.8	-0.7	0.7	0.6	0.6	-0.4
Bone: endosteal estimation	0.1	0.2	0.4	0.3	-0.4	-0.1	0.4	-0.6	0.5	-0.1	-0.2	-0.5
Bone: endosteal perimeter	0.1	0.2	0.6	0.0	-0.4	-0.1	0.5	-0.8	0.4	-0.2	-0.3	-0.8
Epididymis fat weight	0.5	1.1	2.1	-1.5	-0.6	-1.0	1.2	-1.4	-0.1	0.9	0.8	-1.2
Delta time in closed arm before/after self-admin	0.5	0.5	3.0	-1.7	-0.6	-0.6	0.3	-0.1	0.2	0.4	0.4	0.5
Delta time in open arm before/after self-admin	0.5	0.4	1.1	-0.2	-0.7	-0.3	0.8	-1.0	0.7	0.2	0.1	-1.0
Diff in mean of infusions in LGA sessions	0.3	0.4	0.8	-0.2	0.3	0.8	-0.4	0.4	0.5	-0.9	-0.9	-0.8
Delay discount exponential model param	0.1	0.1	0.7	0.7	-0.2	-0.2	0.0	0.1	-0.0	0.2	0.2	0.8
Extinction: sum of active levers before priming	0.8	0.8	3.9	-2.0	0.1	0.4	0.5	-0.5	-1.0	-0.2	-0.4	-1.1
Active lever presses in extinction session 6	0.4	0.4	2.4	-1.6	0.6	0.5	-0.3	0.0	-0.5	-0.3	-0.3	-0.4
Bone: final force	0.5	0.8	3.1	-1.2	-0.1	0.2	0.7	-1.2	-0.1	-0.3	-0.6	-1.8
Bone: final moment	0.6	0.9	3.2	-1.4	-0.4	-0.0	0.9	-1.3	0.2	-0.2	-0.4	-1.8
Food consumed during 24 hour testing period	0.1	0.1	0.3	-0.2	0.0	-0.0	0.2	-0.4	-0.2	0.1	0.0	-0.5
Glucose	0.3	0.5	1.4	1.1	-0.3	-0.4	-0.3	0.4	1.1	0.2	0.5	1.2
Heart weight	0.3	0.5	2.1	1.1	-0.2	0.1	-0.0	-0.3	1.5	-0.4	-0.3	-0.8
Delay discount hyperbolic model param	0.2	0.2	1.0	0.7	-0.1	-0.2	-0.2	0.3	-0.2	0.2	0.2	1.0
Intermittent access intake day 1-15 change	2.1	2.1	6.8	-2.6	-1.5	-1.6	0.4	-0.1	0.7	1.2	1.4	1.8
Intermittent access intake escalation	1.8	1.8	7.0	-2.6	-1.3	-1.3	0.3	-0.1	0.5	1.0	1.2	1.6
Intermittent access intake escalation 2	2.3	2.2	7.0	-2.6	-1.8	-1.8	1.0	-0.8	0.8	1.3	1.4	0.9
Intermitt. access day 1 inactive lever presses	2.0	2.1	2.7	-1.6	1.7	1.6	-1.6	1.3	-1.5	-1.5	-1.5	0.3
Intermitt. access day 15 inactive lever presses	0.7	0.7	2.1	-1.2	-0.0	0.5	0.1	-0.2	0.5	-1.0	-1.1	-1.4
Intermitt. access escalation Index	0.7	0.6	1.3	-1.2	0.2	-0.4	0.4	-0.6	-0.9	1.1	1.1	0.5
Intermittent access day 1 total infusions	5.5	6.4	12.1	-0.8	3.1	3.5	-2.5	2.0	-2.0	-3.1	-3.2	-0.7
Intermittent access day 15 total infusions	2.9	3.3	12.4	-3.5	1.5	1.6	-1.7	1.5	-1.3	-1.6	-1.6	0.7
Intermittent access terminal intake (last 3 days)	3.2	3.5	15.7	-4.0	1.4	1.6	-1.4	1.1	-1.5	-1.6	-1.7	0.1
Intermittent access total infusions	5.6	6.2	9.7	-2.5	3.0	3.1	-2.5	2.1	-2.4	-2.6	-2.7	0.2
Intermittent access day 1 locomotion	4.9	5.2	9.4	-1.2	2.6	3.1	-2.1	1.5	-1.5	-2.9	-3.1	-1.5
Intermittent access day 15 total locomotion	3.6	3.9	12.0	-3.5	2.0	2.0	-1.9	1.5	-1.7	-1.8	-1.8	0.2
Intermittent access total locomotion	4.4	5.0	8.2	-2.4	2.4	2.8	-1.9	1.4	-1.7	-2.7	-2.9	-1.3
Intermittent access standard deviation	0.5	0.5	3.3	-1.8	-0.7	-0.0	0.0	0.1	0.7	-0.4	-0.5	0.4
Left kidney weight	0.6	1.7	4.4	-0.2	0.4	-0.7	1.4	-2.1	-1.7	1.2	1.0	-1.8
Right kidney weight	0.8	2.4	5.7	-1.8	0.5	-0.4	1.5	-2.4	-1.7	1.0	0.7	-2.4
Cocaine induced anxiety	0.4	0.5	2.4	-0.6	0.3	0.3	0.1	-0.3	-0.6	-0.6	-0.8	-1.6
Post-drug Anxiety	0.4	0.4	0.8	-0.2	0.6	0.5	-0.7	0.4	0.1	-0.9	-0.9	-0.8
Baseline Anxiety	0.7	0.7	3.3	0.1	0.5	0.2	-1.1	1.2	0.4	-0.1	0.2	1.8
Tail length	0.5	1.4	8.1	-2.8	1.3	0.9	-0.7	-0.1	-0.5	-0.7	-0.7	-0.8
Length with tail	0.3	1.1	1.9	-1.0	1.4	1.1	-0.7	0.2	-0.7	-1.1	-1.2	-1.4
Length without tail	0.7	1.5	2.9	0.4	1.3	1.5	-1.1	1.1	-0.9	-1.6	-1.7	-0.8
Times rat made contact with spout	0.0	0.0	0.2	0.4	0.1	0.2	0.1	-0.2	0.2	-0.2	-0.2	-0.2
Lifetime Intake	4.5	5.1	8.2	-2.1	2.8	2.9	-2.4	2.0	-2.1	-2.3	-2.4	0.4
Liver weight, left	1.4	2.2	4.3	-2.1	1.6	1.7	-1.1	0.7	-1.5	-1.5	-1.6	-0.9
Liver weight, right	1.0	1.6	3.1	-1.8	1.5	1.4	-0.9	0.4	-1.5	-1.2	-1.3	-0.9
Locomotor activity	0.7	1.1	4.7	2.2	-1.0	-0.4	0.8	-0.7	1.2	-0.1	-0.2	-1.3
Locomotor testing distance	1.0	1.7	7.1	2.7	-1.4	-0.4	0.8	-0.6	2.0	-0.1	-0.2	-0.9
Locomotor testing rearing	2.5	3.9	13.8	3.7	-2.5	-1.0	1.4	-1.1	3.1	-0.1	-0.2	-0.9
Locomotion in novel chamber	1.9	2.4	5.9	-1.3	2.4	1.8	-1.7	1.1	-2.2	-1.0	-0.9	0.2
Locomotion in novel chamber post-restriction	1.5	1.9	7.5	2.7	-0.7	0.0	0.0	0.1	2.3	-1.1	-1.0	-1.1
Fecal boli incidents, locomotor time 1	2.9	3.2	11.3	-3.4	1.7	1.4	-2.0	1.6	-1.4	-0.8	-0.6	1.8
Change in fecal boli incidents, locomotor task	3.1	2.9	7.4	1.2	-2.2	-1.8	1.8	-1.6	2.7	0.7	0.7	-1.5
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.6	0.8	-0.6	0.0	0.2	-0.2	1.3	-0.7	-0.8	-0.6
Bouts of movement, locomotor time 1	0.6	0.6	2.3	-0.1	-0.4	-0.8	0.6	-0.7	0.0	1.4	1.5	-0.1
Total resting periods, locomotor time 1	0.3	0.3	1.3	-0.5	0.1	-0.3	-0.1	0.0	-0.3	0.9	1.1	0.3
Rest time, locomotor task time 1	0.6	0.6	4.2	0.5	-0.8	-0.3	0.1	-0.1	2.0	-0.4	-0.3	-0.0
Distance moved, locomotor task time 1	0.4	0.5	1.5	0.3	0.7	0.7	0.0	0.1	-1.2	-0.4	-0.6	-1.1
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.5	-0.1	-0.1	0.4	0.3	-0.2
Time >=10cm from walls, locomotor time 2	2.8	3.0	6.2	-1.7	-1.9	-1.7	2.4	-2.5	0.5	1.3	1.0	-1.7
Bouts of movement, locomotor time 2	0.7	0.7	3.4	0.1	0.4	0.8	0.0	-0.3	-0.3	-1.0	-1.1	-1.8
Total resting periods, locomotor time 2	0.6	0.6	2.5	0.2	0.4	0.8	-0.0	-0.2	-0.2	-0.9	-1.1	-1.6
Rest time, locomotor task time 2	0.8	1.0	2.7	0.7	-1.6	-1.0	0.9	-0.6	1.6	0.5	0.4	0.6
Distance moved, locomotor task time 2	0.4	0.5	2.3	-0.5	0.4	0.1	0.5	-0.5	-1.1	0.1	-0.1	-1.5
Vertical activity count, locomotor time 2	0.2	0.3	1.1	0.2	-0.4	-0.4	0.7	-0.5	0.2	0.2	0.2	-1.1
Light reinforcement 1	0.4	0.7	2.6	1.6	-1.0	-0.8	0.6	-0.1	0.3	0.7	0.7	0.8
Light reinforcement 2	1.2	1.5	3.9	1.5	-0.3	-1.3	0.7	-0.4	-0.6	1.9	2.0	1.2
Bone: marrow area	0.1	0.1	0.3	0.3	-0.3	-0.0	0.3	-0.5	0.4	-0.2	-0.2	-0.5
Bone: maximum diameter	0.2	0.4	1.1	0.3	-0.5	-0.3	0.7	-1.1	0.6	0.1	-0.0	-1.0
Bone: maximum force	0.4	0.6	2.2	-0.6	-0.5	-0.2	0.9	-1.3	0.5	-0.0	-0.2	-1.5
Bone: maximum moment	0.5	0.8	2.2	-0.9	-0.7	-0.5	1.1	-1.5	0.7	0.2	0.1	-1.4
Mean time between licks in bursts	0.2	0.2	0.6	-0.6	0.8	0.6	-0.4	0.1	-0.7	-0.2	-0.3	0.1
Mean num. licks in bursts	1.2	1.4	7.4	-2.7	0.5	0.2	0.6	-1.3	-0.9	0.0	-0.2	-1.5
Cd content in liver	1.8	2.0	5.8	0.6	1.6	0.8	-2.1	2.0	-0.6	-0.4	-0.0	2.4
Co content in liver	2.0	2.3	4.2	-0.9	1.5	2.1	-1.7	1.5	-0.5	-2.1	-2.0	-0.2
Cu content in liver	0.9	1.1	4.1	-0.9	0.1	0.9	0.0	-0.3	0.2	-1.3	-1.4	-2.0
Fe content in liver	1.7	2.0	5.4	0.4	1.6	1.1	-1.6	1.8	-1.8	-0.4	-0.3	2.3
K content in liver	2.0	2.0	6.9	-2.5	1.4	0.4	0.3	-0.8	-2.6	0.3	-0.0	-1.3
Mg content in liver	0.9	0.9	2.6	-1.1	0.3	-0.3	0.9	-1.1	-1.6	0.7	0.4	-1.1
Mn content in liver	1.5	1.7	7.2	-1.4	1.9	1.1	-0.6	0.2	-2.7	-0.3	-0.5	-0.1
Na content in liver	0.8	0.9	2.6	-1.5	0.1	0.9	0.3	-0.5	-0.3	-0.9	-1.1	-1.6
Rb content in liver	1.6	2.0	3.6	-1.8	1.1	1.8	-0.9	0.7	-1.0	-1.7	-1.9	-1.2
Se content in liver	1.3	1.6	4.4	-0.3	1.7	1.7	-1.1	0.9	-2.1	-1.1	-1.2	0.3
Sr content in liver	2.3	2.1	3.3	1.2	-1.7	-1.8	1.5	-1.6	1.7	1.3	1.3	-0.7
Zn content in liver	2.2	2.5	5.6	-1.2	-0.8	-1.5	2.1	-2.4	-0.6	1.6	1.3	-1.8
Bone: minimum diameter	0.3	0.5	1.4	0.0	-0.7	-0.7	0.8	-1.2	0.8	0.4	0.4	-0.6
Time in familiar zone, hab. session 1	1.3	1.2	2.3	0.2	-1.4	-1.5	1.0	-1.0	1.5	1.0	1.1	-0.5
Time in novel zone, hab. session 1	0.4	0.4	1.0	0.5	0.6	1.0	-0.5	0.5	-0.6	-0.8	-0.9	0.2
Total zone transitions, hab. session 1	2.0	2.8	7.2	-0.1	-2.2	-1.2	2.2	-2.1	1.6	0.3	-0.0	-2.7
Total locomotion distance, hab. session 1	1.8	2.6	10.1	-1.6	-1.2	-0.8	2.0	-2.1	0.2	0.3	-0.1	-3.2
Locomotion velocity, hab. session 1	1.5	2.2	8.0	-1.3	-1.3	-0.9	1.9	-1.9	0.3	0.3	-0.0	-2.8
Time in familiar zone, hab. session 2	0.5	0.5	1.5	-0.7	-0.7	-0.5	1.0	-1.0	0.3	0.3	0.1	-1.2
Time in novel zone, hab. session 2	0.3	0.3	0.6	0.8	-0.1	-0.4	0.2	-0.1	-0.2	0.7	0.7	0.7
Total zone transitions, hab. session 2	2.8	3.7	7.4	0.0	-2.2	-1.9	2.6	-2.6	1.4	1.1	0.8	-2.7
Total locomotion distance, hab. session 2	2.6	3.4	6.9	-0.5	-1.8	-1.8	2.6	-2.6	0.5	1.4	1.0	-2.6
Locomotion velocity, hab. session 2	2.4	3.2	8.5	-0.7	-1.8	-1.6	2.5	-2.5	0.6	1.1	0.7	-2.9
Novel to familiar place preference ratio	2.2	2.3	5.8	-2.0	1.1	1.5	-0.2	-0.2	-1.1	-1.5	-1.8	-2.4
Novelty place preference	1.9	2.0	6.0	-1.8	0.8	1.3	-0.1	-0.3	-0.9	-1.5	-1.8	-2.4
Time in novel zone, NPP test	1.8	1.9	6.5	-2.0	0.6	1.1	0.2	-0.5	-0.7	-1.3	-1.6	-2.5
Total zone transitions, NPP test	2.1	3.0	5.4	-0.3	-2.0	-2.0	2.3	-2.3	1.0	1.5	1.3	-1.8
Total locomotion distance, NPP test	3.6	4.9	9.4	-0.3	-2.2	-2.5	3.1	-3.0	0.4	2.3	2.0	-2.2
Locomotion velocity, NPP test	3.3	4.6	8.8	-0.3	-2.1	-2.5	3.0	-2.9	0.3	2.3	2.0	-2.0
Intraocular pressure	0.3	0.4	2.2	0.2	-0.2	-0.0	-0.6	0.7	0.9	-0.1	0.1	1.5
Delta distance traveled before/after self-admin	0.3	0.3	0.9	0.3	-0.7	-0.7	0.5	-0.5	0.9	0.5	0.6	0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	-0.6	-0.2	-0.3	-0.1	0.0	0.6	0.1	0.2	0.6
Parametrial fat weight	0.1	0.2	0.7	0.2	0.8	-0.0	-0.3	-0.1	-0.8	0.4	0.4	0.5
Pavlov. Cond. lever latency	1.2	1.6	3.4	1.4	-1.8	-0.9	1.4	-1.1	1.8	0.3	0.2	-1.1
Pavlov. Cond. magazine entry latency	0.6	0.8	2.1	-1.3	-0.4	-0.6	1.0	-1.4	0.0	0.4	0.3	-1.4
Pavlov. Cond. change in total contacts	2.3	2.5	5.6	-1.4	2.4	1.7	-1.9	1.4	-1.8	-1.2	-1.1	0.8
Pavlov. Cond. index score	0.5	0.6	2.3	-1.5	1.1	0.4	-0.6	0.2	-1.2	-0.1	-0.0	0.3
Pavlov. Cond. latency score	0.7	0.9	3.1	-1.8	1.3	0.5	-0.7	0.3	-1.4	-0.1	-0.1	0.4
Pavlov. Cond. lever contacts	0.8	1.0	2.8	-1.4	1.4	0.3	-0.8	0.4	-1.7	0.3	0.4	1.0
Pavlov. Cond. magazine entry number	0.2	0.3	1.3	1.2	-0.6	0.0	0.0	0.5	0.6	-0.2	-0.2	0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	0.6	0.2	0.9	-0.6	0.7	0.1	-1.0	-1.0	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	2.5	-1.6	1.2	0.5	-0.7	0.2	-1.1	-0.1	-0.1	0.2
Pavlov. Cond. response bias	0.2	0.3	0.8	-0.8	0.8	0.1	-0.3	-0.1	-0.9	0.3	0.3	0.3
Pavlov. Cond. lever latency	3.2	4.3	8.9	-0.6	2.2	2.1	-2.8	3.0	-1.5	-1.7	-1.5	2.1
Pavlov. Cond. magazine entry latency	1.7	2.0	4.1	2.0	-0.6	-1.5	0.7	-0.3	0.1	1.9	2.0	1.8
Pavlov. Cond. change in total contacts	3.0	4.2	7.7	1.3	-2.8	-2.0	2.4	-2.3	2.8	1.0	0.9	-1.9
Pavlov. Cond. index score	2.3	3.0	4.5	1.7	-1.8	-2.1	2.0	-1.9	1.2	2.0	1.9	-0.3
Pavlov. Cond. latency score	2.7	3.4	5.1	1.7	-1.8	-2.3	2.0	-1.9	1.2	2.2	2.2	-0.1
Pavlov. Cond. lever contacts	2.8	3.8	8.5	0.4	-1.9	-2.1	2.6	-2.9	1.2	1.8	1.6	-2.0
Pavlov. Cond. magazine entry number	2.0	2.4	5.7	-2.4	1.7	1.8	-1.4	0.9	-1.3	-1.6	-1.7	-0.6
Pavlov. Cond. intertrial magazine entries	1.1	1.4	3.5	-1.9	1.3	1.0	-0.2	-0.3	-1.8	-0.7	-0.9	-1.3
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.2	4.9	1.7	-1.8	-2.2	2.0	-1.9	1.1	2.1	2.1	-0.2
Pavlov. Cond. response bias	2.2	2.9	5.2	1.1	-1.8	-1.9	2.2	-2.3	1.2	1.7	1.5	-1.2
Time in closed arm before self-admin	1.1	1.2	5.2	2.3	-0.7	-0.7	1.1	-1.2	0.8	0.7	0.6	-0.7
Time in closed arm after self-admin	0.2	0.2	0.9	0.5	0.4	0.2	-0.4	0.5	-0.0	0.1	0.2	1.0
Time in open arm before self-admin	0.8	0.9	2.1	-1.4	0.6	0.9	-0.9	0.9	-0.8	-1.0	-1.1	-0.2
Time in open arm after self-admin	0.7	0.8	1.7	-0.9	-1.1	-0.7	1.2	-1.3	0.2	0.5	0.3	-1.1
Bone: periosteal estimation	0.2	0.3	1.4	-0.1	-0.4	-0.5	0.7	-1.2	0.2	0.4	0.3	-0.7
Bone: periosteal perimeter	0.6	0.9	2.4	0.1	-1.0	-0.9	1.3	-1.5	0.8	0.6	0.5	-1.1
Bone: post-yield work	0.6	0.8	3.4	-0.7	-0.6	-0.1	0.9	-1.3	0.6	-0.3	-0.5	-1.8
Progressive ratio test 1 active lever presses	2.8	2.9	4.7	-1.6	2.1	2.2	-1.6	1.4	-1.6	-1.9	-2.0	-0.0
Progressive ratio test 1 breakpoint	2.6	2.7	4.2	-1.8	2.0	2.1	-1.5	1.3	-1.5	-1.8	-1.9	-0.1
Progressive ratio test 1 inactive lever presses	0.4	0.4	3.0	1.7	0.3	0.2	-0.4	0.4	-0.2	-0.2	-0.2	0.6
Progressive ratio test 2 active lever presses	6.2	6.6	11.1	-2.2	3.3	3.3	-2.7	2.4	-2.8	-2.4	-2.5	0.7
Progressive ratio test 2 breakpoint	5.4	6.0	9.9	-2.2	3.1	3.1	-2.5	2.3	-2.7	-2.3	-2.3	0.7
Progressive ratio test 2 inactive lever presses	2.3	2.6	4.2	-2.0	1.6	2.0	-1.5	1.2	-1.4	-1.9	-2.0	-0.0
Incentive Sensitization - Responses	3.5	3.6	6.0	-1.4	2.4	2.5	-2.0	1.8	-2.5	-1.5	-1.5	1.0
Incentive Sensitization - Breakpoint	3.8	3.9	6.7	-1.4	2.5	2.5	-2.1	1.9	-2.6	-1.5	-1.5	1.1
Sum of active levers in priming session hrs 5-6	0.7	0.7	2.8	-1.4	-0.4	-0.1	0.8	-0.9	-0.2	0.0	-0.2	-1.7
Progressive ratio	0.8	0.9	3.9	-2.0	0.6	0.6	-0.8	0.9	-0.9	-0.4	-0.4	0.9
Food seeking constrained by brief footshock	0.8	1.0	2.1	-1.2	-0.3	-1.2	0.8	-0.6	-0.7	1.5	1.5	0.2
Seeking ratio, punishment vs. effort	1.3	1.6	2.5	1.5	-0.8	-1.3	1.4	-1.4	0.1	1.6	1.5	-0.7
Retroperitoneal fat weight	0.3	1.0	5.5	2.3	-0.8	-0.7	0.6	-0.6	0.8	0.5	0.5	-0.2
Reaction time number correct	2.8	4.0	8.0	1.3	-2.8	-2.5	2.0	-1.4	2.2	2.1	2.1	0.7
Reaction time mean minus median	2.1	2.8	5.1	2.3	-1.6	-1.6	2.2	-2.1	0.3	1.7	1.5	-1.0
Reaction time mean minus median AUC	2.6	3.4	5.3	2.3	-1.7	-2.0	2.2	-2.0	-0.0	2.3	2.1	-0.2
Reaction time num false alarms	1.6	2.2	4.1	-1.3	2.0	1.6	-1.7	1.5	-1.9	-1.0	-0.9	1.0
Reaction time num false alarms AUC	2.1	2.9	5.2	-1.7	2.3	1.6	-2.0	1.8	-2.1	-1.0	-0.9	1.3
Reaction time trials correct on left	2.8	4.0	8.0	1.3	-2.8	-2.5	2.0	-1.4	2.2	2.1	2.1	0.7
Reaction time trials on left	3.1	4.4	8.6	1.4	-2.9	-2.6	2.1	-1.5	2.2	2.2	2.2	0.7
Reaction time mean	0.4	0.6	2.6	0.8	0.2	0.7	0.6	-0.7	-0.7	-0.4	-0.6	-1.6
Reaction time mean AUC	0.4	0.6	1.8	0.7	0.4	0.9	0.3	-0.2	-0.8	-0.6	-0.9	-1.3
Median of all reaction times	0.7	1.0	2.7	0.4	0.8	1.3	0.0	-0.1	-1.0	-1.0	-1.2	-1.6
Reaction time omissions	1.5	2.1	3.7	1.9	-1.8	-1.4	1.8	-1.6	0.9	1.3	1.2	-0.5
Reaction time false alarm rate	4.0	5.6	11.1	-2.3	3.3	2.5	-2.7	2.2	-3.0	-1.7	-1.6	1.0
Reaction time premature initiation rate	1.5	2.1	4.3	0.6	-0.4	-1.6	1.6	-1.8	-1.2	2.1	1.9	-0.3
Reaction time premature initiations	3.4	4.8	9.2	1.6	-1.9	-2.8	2.4	-2.3	0.2	3.0	3.0	0.4
Std. dev. reaction times	0.8	1.2	3.6	1.9	-0.6	-0.4	1.4	-1.4	-0.3	0.9	0.6	-1.0
Reaction time trials completed	3.1	4.4	8.6	1.4	-2.9	-2.6	2.1	-1.5	2.2	2.2	2.2	0.7
Reaction time trials AUC	2.8	4.0	7.9	1.3	-2.8	-2.5	2.1	-1.5	2.1	2.1	2.1	0.5
Run reversals in cocaine runway, females	0.6	0.6	1.5	-1.2	0.3	-0.9	0.3	-0.4	-0.9	0.9	1.0	0.3
Run reversals in cocaine runway, males	2.7	2.6	6.6	-0.6	1.6	1.5	-2.2	2.6	-0.5	-1.0	-0.7	2.2
Latency to leave start box in cocaine runway	0.7	0.8	5.1	2.3	0.2	-0.4	-0.4	0.7	0.7	0.3	0.5	0.6
Latency to leave start box in cocaine runway, F	0.2	0.3	0.7	0.7	0.6	-0.0	-0.8	0.8	0.0	-0.1	0.0	0.6
Latency to leave start box in cocaine runway, M	1.0	0.9	4.7	2.2	0.2	-0.1	-0.6	0.9	0.6	0.3	0.6	1.3
Std. dev. time between licks in bursts	0.2	0.2	0.9	-0.2	0.5	0.1	-0.4	0.3	-0.8	0.3	0.3	0.9
Total sessions with >9 infusions	4.4	4.9	7.4	-2.5	2.6	2.7	-2.3	2.0	-2.1	-2.2	-2.2	0.5
Short access day 1 total inactive lever presses	0.7	0.8	1.5	0.6	1.2	1.2	-1.0	0.9	-0.5	-1.0	-0.9	0.4
Short access day 10 total inactive lever presses	0.6	0.7	1.4	0.6	-0.7	-0.9	1.2	-1.2	0.2	0.9	0.7	-0.8
Short access day 1 total infusions	1.7	1.8	3.5	-1.2	1.9	1.6	-1.4	1.2	-1.5	-1.1	-1.1	0.5
Short access day 10 total infusions	4.9	5.4	8.8	-1.8	2.9	3.0	-2.6	2.3	-2.0	-2.5	-2.5	0.7
Short access total infusions	2.8	3.1	5.7	-1.1	2.3	2.4	-2.0	1.7	-1.5	-1.8	-1.8	0.5
Short access day 1 locomotion	1.0	1.1	2.0	-0.5	1.4	1.3	-1.2	1.1	-1.2	-0.9	-0.9	0.4
Short access day 10 total locomotion	1.3	1.4	5.9	-1.2	0.6	1.0	-0.1	-0.4	-0.2	-1.3	-1.5	-2.4
Short access total locomotion	2.4	2.5	4.7	-1.2	1.9	2.2	-1.4	0.9	-0.9	-2.0	-2.1	-1.1
One hour access (0.3 mA shock)	1.1	1.3	9.6	-3.1	-0.0	-0.1	0.2	-0.3	-1.0	-0.3	-0.5	-0.8
Compulsive drug intake	1.5	1.5	3.0	0.9	-1.0	-1.6	1.2	-1.2	0.2	1.7	1.7	-0.2
One hour access (shock baseline)	2.5	2.9	14.8	-3.8	1.0	1.2	-1.1	1.0	-1.2	-1.6	-1.7	-0.2
Social response proportion	1.4	1.5	7.2	2.7	-0.7	-0.8	1.3	-1.2	-0.0	0.9	0.8	-0.8
Social responses	4.0	5.1	18.5	4.3	-2.9	-2.0	2.0	-1.4	2.7	1.1	1.0	-0.4
Social time	2.2	3.0	9.3	3.1	-2.1	-1.1	1.8	-1.4	2.0	0.2	-0.1	-1.6
Soleus weight	0.3	0.8	1.5	-1.2	0.4	-0.6	0.6	-1.1	-0.9	1.0	0.9	-0.6
Bone: stiffness	0.6	0.9	2.8	-0.8	0.5	0.9	-0.0	-0.6	-0.3	-1.1	-1.3	-1.7
Tibialis anterior weight	0.9	3.2	7.9	-1.1	-0.8	-1.9	2.2	-2.8	-0.2	2.1	1.9	-1.7
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.5	0.1	0.3	-0.4	0.4	0.4	-0.7	-0.6	-0.1
Time to tail flick, vehicle, after self-admin	1.3	1.4	7.5	2.7	-0.6	-0.2	-0.4	0.6	2.0	-0.4	-0.1	0.5
Time to tail flick, test, before self-admin	1.5	1.5	2.6	-0.7	1.6	1.4	-1.6	1.3	-0.8	-1.2	-1.1	0.7
Time to tail flick, test, after self-admin	0.9	0.9	1.9	-0.0	0.9	1.3	-1.2	0.9	0.4	-1.4	-1.3	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	2.3	1.5	-0.3	-0.2	0.1	-0.2	1.0	0.1	0.2	-0.1
Delta time to tail flick, test, before/after SA	0.8	0.7	1.2	0.9	-1.0	-0.7	0.9	-0.8	1.1	0.5	0.5	-0.7
Tibia length	0.4	1.1	4.5	-1.3	1.4	1.0	-0.6	0.4	-2.1	-0.5	-0.6	-0.2
Ambulatory time before self-admin	3.2	3.4	6.0	1.3	2.5	2.3	-1.9	2.0	-2.2	-1.4	-1.4	0.6
Ambulatory time after self-admin	2.8	3.1	5.2	1.7	2.3	2.2	-1.9	1.8	-1.6	-1.5	-1.5	0.7
Bone: tissue strength	1.3	1.3	2.4	0.5	-1.4	-1.3	1.5	-1.4	0.8	1.1	1.0	-0.9
Total heroin consumption	0.6	0.7	1.5	-1.0	0.4	1.1	-0.7	0.8	-0.1	-1.2	-1.2	-0.3
Bone: trabecular number	0.1	0.2	0.4	-0.2	0.4	0.6	-0.4	0.1	-0.1	-0.6	-0.6	-0.2
Bone: trabecular spacing	0.3	0.3	0.8	0.4	-0.4	-0.7	0.4	-0.3	0.1	0.9	0.9	0.6
Bone: trabecular thickness	0.4	0.5	2.0	-0.8	-0.5	-0.1	0.7	-0.9	0.4	-0.2	-0.4	-1.4
Bone: trabecular tissue density	0.6	0.9	2.1	0.4	0.6	1.2	-0.9	1.0	0.1	-1.4	-1.4	-0.3
Water consumed over 24 hours	0.7	0.8	2.3	1.5	0.0	0.3	-0.8	1.1	1.0	-0.5	-0.3	1.3
Number of responses in last shaping day	3.2	3.3	5.3	-2.3	2.0	2.0	-2.1	1.9	-1.2	-1.9	-1.8	0.8