Hub : Genes

Bltp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Bltp2 0.17 0.14 4.3e-06 0.11 0.1 0.12 0.11 3.3e-05 4.2e-05 1.1e-05 1.8e-05
2 Adipose mRNA stability Bltp2 0.08 0.06 4.7e-08 0.06 0.06 0.06 0.06 4.9e-07 2.6e-07 1.7e-07 2.2e-07
3 Adipose gene expression Bltp2 0.24 0.12 0.0e+00 0.25 0.26 0.25 0.26 3.8e-27 4.0e-28 7.3e-28 4.4e-28
4 Liver gene expression Bltp2 0.16 0.15 1.1e-10 0.09 0.08 0.08 0.09 1.1e-09 1.7e-09 2.0e-09 7.7e-10
5 PL gene expression Bltp2 0.06 0.04 9.9e-07 0.05 0.06 0.06 0.06 5.6e-06 5.0e-07 6.9e-07 1.0e-06
6 Brain gene expression Bltp2 0.22 0.13 0.0e+00 0.24 0.25 0.25 0.24 8.6e-22 1.2e-23 3.5e-23 1.6e-22
7 NAcc gene expression Bltp2 0.14 0.1 0.0e+00 0.13 0.14 0.13 0.13 3.4e-19 5.8e-20 2.2e-19 1.4e-19
8 pVTA gene expression Bltp2 0.12 0.12 1.4e-05 0.05 0.05 0.04 0.06 1.3e-04 3.7e-05 2.3e-04 1.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.13.84.1-2.0-1.92.01.72.02.02.02.0
Area under the delay curve1.42.13.11.01.0-1.5-1.0-1.6-1.7-1.8-1.8
BMI with tail1.86.37.0-2.6-2.52.52.42.42.42.42.6
BMI without tail1.26.47.2-2.6-2.42.62.22.62.62.62.7
Body weight2.711.813.3-3.6-3.53.53.33.43.43.33.4
Weight adjusted by age0.10.20.5-0.7-0.10.40.30.40.50.50.4
Bone surface1.52.93.1-1.8-1.61.71.41.71.71.71.8
Bone volume1.32.52.8-1.7-1.61.61.41.61.61.61.6
Breakpoint value in progressive ratio session0.30.51.0-0.4-0.50.80.50.90.91.00.8
Number of licking bursts0.20.51.01.00.7-0.6-0.6-0.6-0.6-0.6-0.6
Context. condit. distance diff. score0.60.70.8-0.9-0.80.80.80.80.80.80.8
Locomotion velocity, session 12.12.42.7-1.6-1.61.61.51.51.51.51.5
Locomotion distance, session 10.20.30.4-0.5-0.60.60.40.50.50.50.5
Locomotion velocity, session 20.00.00.1-0.1-0.10.20.10.20.20.20.2
Locomotion distance, session 21.21.72.1-1.3-1.31.31.41.31.31.31.3
Locomotion velocity, session 33.54.04.62.12.1-2.0-2.1-1.9-1.9-1.9-1.9
Locomotion distance, session 30.40.50.60.70.6-0.7-0.8-0.7-0.7-0.7-0.7
Stereotopy head waving bouts, day 30.00.00.0-0.00.10.10.10.10.20.20.2
Stereotopy head waving duration, day 30.50.61.10.91.1-0.8-0.9-0.6-0.6-0.6-0.5
Locomotion velocity, session 70.30.30.5-0.4-0.30.50.20.60.70.70.7
Locomotion distance, session 70.40.60.7-0.7-0.60.80.50.80.80.90.8
Stereotopy head waving bouts, day 70.50.60.6-0.8-0.70.80.80.80.80.80.8
Stereotopy head waving duration, day 70.20.30.4-0.5-0.30.50.40.60.60.60.6
Locomotion velocity, session 80.00.00.1-0.2-0.20.20.20.10.10.10.1
Locomotion distance, session 80.81.21.3-1.1-1.01.11.11.11.11.11.1
Degree of sensitization distance3.23.43.6-1.9-1.71.81.81.91.91.91.9
Degree of sensitization stereotypy0.60.60.7-0.8-0.70.80.80.80.80.80.8
Conditioned locomotion1.61.92.61.61.6-1.4-1.4-1.3-1.3-1.3-1.2
Cocaine response after cond. corrected1.32.02.3-1.5-1.41.41.51.41.41.41.3
Cocaine response after cond. not corrected1.82.62.9-1.7-1.61.61.71.61.61.61.5
Cocaine response before conditioning0.20.20.3-0.5-0.40.50.30.50.50.50.4
Saline control response0.00.00.00.10.2-0.0-0.2-0.0-0.00.00.0
Bone: connectivity density3.86.06.8-2.5-2.32.52.12.52.52.52.6
Bone: cortical apparent density0.40.60.90.90.9-0.8-0.7-0.7-0.7-0.7-0.7
Bone: cortical area1.42.32.61.41.4-1.5-1.5-1.5-1.5-1.5-1.6
Bone: cortical porosity0.30.30.4-0.5-0.40.50.20.60.60.60.7
Bone: cortical porosity0.10.10.2-0.4-0.30.30.10.40.40.40.5
Bone: cortical thickness2.94.85.32.22.2-2.2-2.3-2.2-2.1-2.1-2.2
Bone: cortical thickness0.00.00.20.20.3-0.2-0.4-0.1-0.1-0.1-0.1
Bone: cortical tissue density0.20.30.50.70.7-0.6-0.5-0.5-0.5-0.5-0.5
Condit. Reinf. active minus inactive responses0.80.91.21.01.0-0.9-1.1-0.9-0.9-0.8-0.8
Condit. Reinf. active-inactive response ratio0.20.20.40.40.4-0.4-0.6-0.4-0.4-0.4-0.4
Condit. Reinf. active responses0.00.00.10.20.1-0.1-0.2-0.1-0.1-0.1-0.1
Condit. Reinf. inactive responses0.30.40.7-0.5-0.60.60.80.60.60.60.6
Incentive salience index mean0.30.40.50.70.6-0.6-0.7-0.6-0.6-0.6-0.6
Condit. Reinf. lever presses0.10.10.1-0.3-0.30.30.30.30.30.30.3
Condit. Reinf. active minus inactive responses0.30.50.90.90.9-0.7-0.9-0.5-0.5-0.5-0.4
Condit. Reinf. active-inactive response ratio0.40.60.91.00.9-0.8-0.8-0.8-0.8-0.7-0.6
Condit. Reinf. active responses0.20.30.60.70.8-0.5-0.8-0.4-0.4-0.3-0.3
Condit. Reinf. inactive responses0.00.00.1-0.10.00.2-0.10.20.20.30.2
Condit. Reinf. lever presses2.43.43.82.01.9-1.9-1.8-1.8-1.8-1.8-1.7
Condit. Reinf. lever reinforcers received0.40.61.00.91.0-0.8-1.0-0.7-0.7-0.6-0.6
Conditioned reinforcement - actives0.10.30.5-0.5-0.70.60.60.60.60.60.5
Conditioned reinforcement - inactives0.00.10.2-0.4-0.40.40.40.30.30.30.3
Conditioned locomotion0.30.41.0-0.8-0.80.61.00.50.50.40.4
Patch foraging indifference point 0 sec0.30.71.20.90.9-0.9-1.1-0.8-0.8-0.8-0.7
Patch foraging indifference point AUC1.33.13.61.91.8-1.8-1.6-1.8-1.7-1.7-1.7
Delay disc. indifference point, 0s delay0.91.01.21.00.8-1.0-0.7-1.0-1.1-1.1-1.1
Delay disc. indifference point, 16s delay1.01.42.40.60.6-1.2-0.5-1.4-1.4-1.5-1.5
Delay disc. indifference point, 2s delay2.62.93.21.61.7-1.7-1.5-1.8-1.8-1.8-1.7
Delay disc. indifference point, 24s delay0.50.81.3-1.1-0.90.80.90.80.80.80.8
Delay disc. indifference point, 4s delay0.20.20.40.30.3-0.4-0.4-0.5-0.6-0.6-0.6
Delay disc. indifference point, 8s delay0.61.11.60.60.7-1.1-0.6-1.2-1.2-1.3-1.3
Indifference point function ln k0.30.91.0-0.9-0.91.00.71.01.01.01.0
Indifference point function log k0.30.91.0-0.9-0.91.00.71.01.01.01.0
Patch foraging total patch changes 0 sec0.20.61.10.80.9-0.7-1.0-0.7-0.7-0.6-0.5
Patch foraging total patch changes 12 sec0.20.20.30.50.4-0.5-0.4-0.5-0.5-0.5-0.5
Patch foraging total patch changes 18 sec1.02.43.01.71.7-1.6-1.6-1.5-1.5-1.5-1.4
Patch foraging total patch changes 24 sec0.93.13.92.01.8-1.8-1.8-1.7-1.7-1.7-1.6
Patch foraging total patch changes 6 sec3.05.15.32.32.2-2.3-2.1-2.3-2.3-2.3-2.2
Patch foraging time to switch 0 sec0.72.53.0-1.7-1.61.61.71.51.51.51.4
Patch foraging water rate 0 sec0.83.03.41.81.8-1.7-1.8-1.7-1.7-1.6-1.6
Patch foraging water rate 12 sec0.10.30.6-0.5-0.50.50.40.60.60.70.8
Patch foraging water rate 18 sec0.40.80.9-1.0-0.90.91.00.80.80.80.9
Patch foraging water rate 24 sec0.20.20.30.40.3-0.5-0.5-0.5-0.5-0.5-0.6
Patch foraging water rate 6 sec1.01.51.81.31.3-1.2-1.4-1.2-1.2-1.1-1.1
Seeking ratio, delayed vs. immediate footshock1.82.53.31.61.4-1.5-1.4-1.6-1.6-1.7-1.8
Distance traveled before self-admin2.14.55.11.82.2-2.2-2.3-2.2-2.2-2.1-2.0
Distance traveled after self-admin0.00.10.10.00.2-0.3-0.3-0.3-0.3-0.4-0.3
Extensor digitorum longus weight0.83.13.9-2.0-1.81.81.81.71.71.71.6
Bone: elastic displacement2.83.53.71.91.9-1.9-1.9-1.9-1.9-1.9-1.9
Bone: elastic work8.911.614.13.53.3-3.4-3.8-3.3-3.3-3.3-3.4
Bone: endosteal estimation0.00.00.0-0.1-0.1-0.0-0.0-0.1-0.1-0.1-0.2
Bone: endosteal perimeter0.00.00.1-0.3-0.30.10.30.10.0-0.0-0.1
Epididymis fat weight5.628.532.6-5.7-5.45.45.55.25.25.25.0
Delta time in closed arm before/after self-admin2.92.73.31.31.8-1.7-1.7-1.7-1.7-1.6-1.8
Delta time in open arm before/after self-admin5.05.97.5-1.8-2.72.52.52.42.42.42.5
Diff in mean of infusions in LGA sessions0.40.60.8-0.5-0.90.80.90.80.80.80.8
Delay discount exponential model param1.01.42.1-0.8-0.81.20.81.31.41.41.4
Extinction: sum of active levers before priming0.71.01.3-0.8-1.01.00.91.11.11.11.0
Active lever presses in extinction session 60.30.30.6-0.7-0.20.50.00.70.70.80.8
Bone: final force0.40.61.10.60.6-0.7-1.1-0.7-0.7-0.8-0.8
Bone: final moment0.40.71.20.70.6-0.8-1.1-0.8-0.8-0.8-0.8
Food consumed during 24 hour testing period0.10.30.80.20.7-0.5-0.9-0.4-0.4-0.3-0.4
Glucose1.42.22.41.51.5-1.5-1.3-1.5-1.5-1.5-1.5
Heart weight1.52.42.9-1.6-1.31.61.21.71.71.71.7
Delay discount hyperbolic model param1.51.92.6-1.0-1.11.41.11.51.51.61.6
Intermittent access intake day 1-15 change0.00.00.1-0.1-0.10.20.10.20.20.20.4
Intermittent access intake escalation0.00.10.2-0.2-0.30.30.20.40.30.30.4
Intermittent access intake escalation 20.10.20.20.50.5-0.4-0.4-0.4-0.4-0.4-0.3
Intermitt. access day 1 inactive lever presses0.00.20.30.40.4-0.4-0.5-0.4-0.4-0.4-0.4
Intermitt. access day 15 inactive lever presses0.10.81.91.40.9-0.8-0.7-0.8-0.8-0.8-0.8
Intermitt. access escalation Index0.41.42.4-1.4-1.41.11.61.01.00.91.0
Intermittent access day 1 total infusions0.10.20.8-0.3-0.70.40.90.30.30.30.2
Intermittent access day 15 total infusions0.41.11.8-0.7-1.21.11.31.01.00.91.0
Intermittent access terminal intake (last 3 days)0.71.21.9-1.0-1.31.11.41.01.01.01.0
Intermittent access total infusions0.30.41.0-0.4-0.80.61.00.50.50.40.5
Intermittent access day 1 locomotion0.00.00.2-0.1-0.30.10.40.00.0-0.0-0.1
Intermittent access day 15 total locomotion0.10.50.7-0.7-0.80.70.90.70.60.60.6
Intermittent access total locomotion0.50.60.9-0.7-0.90.80.90.70.70.70.7
Intermittent access standard deviation0.00.00.10.3-0.2-0.00.3-0.1-0.1-0.1-0.3
Left kidney weight0.00.20.3-0.5-0.50.50.40.50.50.40.3
Right kidney weight0.10.71.0-1.0-0.90.80.80.80.80.80.7
Cocaine induced anxiety0.10.20.50.70.4-0.4-0.4-0.4-0.4-0.4-0.3
Post-drug Anxiety0.20.20.4-0.2-0.30.40.30.50.50.50.6
Baseline Anxiety0.20.40.6-0.6-0.40.60.40.70.70.80.7
Tail length0.31.71.9-1.4-1.31.41.11.41.41.41.3
Length with tail0.62.63.1-1.8-1.71.61.51.61.61.61.5
Length without tail0.21.21.8-1.3-1.31.11.21.00.90.90.9
Times rat made contact with spout0.10.10.5-0.10.4-0.2-0.7-0.1-0.1-0.0-0.1
Lifetime Intake0.40.61.2-0.5-1.00.71.10.60.60.50.5
Liver weight, left5.08.69.5-3.1-3.02.93.02.92.92.92.8
Liver weight, right4.07.07.7-2.8-2.62.72.62.62.62.62.6
Locomotor activity0.00.00.00.10.1-0.2-0.1-0.2-0.2-0.2-0.1
Locomotor testing distance0.00.10.10.30.3-0.3-0.1-0.3-0.4-0.4-0.3
Locomotor testing rearing0.00.10.20.30.4-0.3-0.3-0.2-0.2-0.2-0.3
Locomotion in novel chamber2.33.13.81.21.6-1.8-1.6-1.9-1.9-2.0-1.9
Locomotion in novel chamber post-restriction0.00.00.2-0.4-0.00.0-0.20.00.0-0.0-0.2
Fecal boli incidents, locomotor time 10.82.22.5-1.4-1.31.51.41.51.51.61.5
Change in fecal boli incidents, locomotor task0.20.20.40.30.1-0.4-0.3-0.5-0.5-0.6-0.5
Time >=10cm from walls, locomotor time 10.00.00.0-0.1-0.10.1-0.00.20.10.20.2
Bouts of movement, locomotor time 10.40.50.60.70.7-0.7-0.7-0.7-0.7-0.7-0.8
Total resting periods, locomotor time 10.10.10.10.40.4-0.3-0.3-0.3-0.3-0.3-0.4
Rest time, locomotor task time 10.10.20.3-0.1-0.20.4-0.00.50.60.60.6
Distance moved, locomotor task time 10.20.40.70.50.4-0.7-0.4-0.7-0.8-0.8-0.8
Vertical activity count, locomotor time 10.00.20.30.30.0-0.4-0.1-0.5-0.5-0.6-0.5
Time >=10cm from walls, locomotor time 20.30.91.4-0.7-1.21.00.81.00.90.91.0
Bouts of movement, locomotor time 20.10.40.70.70.7-0.6-0.8-0.6-0.6-0.6-0.6
Total resting periods, locomotor time 20.00.10.40.40.4-0.3-0.6-0.2-0.2-0.2-0.2
Rest time, locomotor task time 20.10.10.30.30.6-0.0-0.40.20.20.40.3
Distance moved, locomotor task time 20.30.40.80.40.1-0.6-0.1-0.8-0.8-0.9-0.8
Vertical activity count, locomotor time 20.30.71.40.5-0.0-0.7-0.1-1.0-1.0-1.2-1.1
Light reinforcement 10.00.00.00.1-0.0-0.10.1-0.2-0.2-0.2-0.1
Light reinforcement 20.20.50.60.70.7-0.7-0.7-0.8-0.8-0.8-0.8
Bone: marrow area0.00.00.0-0.0-0.1-0.1-0.0-0.1-0.1-0.2-0.2
Bone: maximum diameter0.30.70.90.70.6-0.8-0.8-0.9-0.9-0.9-1.0
Bone: maximum force0.51.01.40.90.8-1.0-1.2-1.0-1.0-1.0-1.1
Bone: maximum moment0.61.21.60.90.9-1.0-1.3-1.1-1.1-1.1-1.1
Mean time between licks in bursts0.20.91.5-1.2-1.01.01.00.90.90.90.8
Mean num. licks in bursts0.20.51.5-1.2-0.60.70.30.70.70.70.7
Cd content in liver0.80.91.71.30.7-0.9-0.5-1.0-1.0-1.0-1.1
Co content in liver0.40.50.90.90.7-0.6-0.6-0.6-0.6-0.6-0.8
Cu content in liver1.61.92.41.51.5-1.4-1.5-1.3-1.3-1.3-1.3
Fe content in liver2.02.42.8-1.2-1.71.61.71.61.61.61.5
K content in liver0.10.10.2-0.3-0.40.30.30.30.30.30.4
Mg content in liver0.70.81.41.20.8-0.8-1.0-0.8-0.8-0.7-0.8
Mn content in liver0.20.20.30.50.6-0.5-0.5-0.4-0.4-0.4-0.4
Na content in liver0.10.10.4-0.1-0.40.20.70.00.0-0.00.1
Rb content in liver0.10.10.10.1-0.30.30.30.30.30.20.3
Se content in liver0.80.92.41.60.8-0.8-1.0-0.8-0.8-0.7-0.8
Sr content in liver0.50.40.5-0.7-0.60.70.60.70.70.70.6
Zn content in liver0.30.40.6-0.2-0.80.70.40.60.60.60.5
Bone: minimum diameter0.10.10.30.20.3-0.3-0.3-0.4-0.4-0.4-0.5
Time in familiar zone, hab. session 10.30.30.40.50.5-0.6-0.4-0.6-0.6-0.6-0.6
Time in novel zone, hab. session 10.10.20.2-0.3-0.30.40.30.40.40.50.5
Total zone transitions, hab. session 10.00.10.10.20.0-0.20.1-0.3-0.3-0.3-0.3
Total locomotion distance, hab. session 10.10.10.20.40.3-0.3-0.2-0.3-0.3-0.3-0.3
Locomotion velocity, hab. session 10.30.40.50.70.6-0.7-0.5-0.7-0.7-0.7-0.7
Time in familiar zone, hab. session 20.10.20.30.50.5-0.4-0.5-0.3-0.3-0.3-0.3
Time in novel zone, hab. session 20.10.10.20.30.2-0.4-0.3-0.4-0.4-0.5-0.5
Total zone transitions, hab. session 20.30.40.7-0.6-0.60.60.80.60.60.50.6
Total locomotion distance, hab. session 20.00.10.10.40.3-0.3-0.1-0.2-0.2-0.2-0.2
Locomotion velocity, hab. session 20.10.10.20.40.4-0.3-0.1-0.3-0.3-0.2-0.2
Novel to familiar place preference ratio0.70.91.1-1.0-1.01.01.00.90.90.90.9
Novelty place preference0.91.21.4-1.2-1.11.11.11.11.11.11.1
Time in novel zone, NPP test1.11.31.4-1.2-1.21.11.11.11.11.11.1
Total zone transitions, NPP test0.00.00.1-0.1-0.20.10.30.10.10.10.1
Total locomotion distance, NPP test0.81.11.51.21.1-1.1-0.9-1.1-1.1-1.0-1.0
Locomotion velocity, NPP test1.01.41.71.31.2-1.2-1.0-1.2-1.2-1.2-1.2
Intraocular pressure1.01.61.91.41.4-1.3-1.1-1.3-1.3-1.2-1.1
Delta distance traveled before/after self-admin2.93.23.5-1.7-1.91.81.81.81.81.81.6
Delta ambulatory time before/after self-admin1.42.53.1-1.2-1.81.61.81.61.61.61.4
Parametrial fat weight6.415.016.6-4.1-3.83.93.93.93.93.93.7
Pavlov. Cond. lever latency0.00.00.0-0.1-0.10.10.10.20.20.20.2
Pavlov. Cond. magazine entry latency0.00.00.0-0.2-0.20.10.20.10.10.10.1
Pavlov. Cond. change in total contacts0.30.40.40.60.6-0.6-0.5-0.6-0.6-0.6-0.6
Pavlov. Cond. index score0.00.00.10.10.1-0.2-0.1-0.2-0.2-0.2-0.2
Pavlov. Cond. latency score0.00.00.0-0.0-0.1-0.00.0-0.1-0.1-0.1-0.1
Pavlov. Cond. lever contacts0.00.00.0-0.0-0.1-0.10.1-0.1-0.1-0.2-0.2
Pavlov. Cond. magazine entry number0.10.20.2-0.4-0.30.40.30.40.40.50.5
Pavlov. Cond. intertrial magazine entries0.20.30.40.60.6-0.5-0.5-0.5-0.5-0.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.10.20.2-0.3-0.2-0.3-0.3-0.4-0.4
Pavlov. Cond. response bias0.00.00.00.0-0.0-0.10.0-0.1-0.1-0.2-0.2
Pavlov. Cond. lever latency2.43.43.7-1.9-1.91.91.71.91.91.81.8
Pavlov. Cond. magazine entry latency0.20.30.30.50.5-0.5-0.5-0.5-0.5-0.5-0.5
Pavlov. Cond. change in total contacts0.92.12.31.51.5-1.5-1.5-1.5-1.5-1.4-1.4
Pavlov. Cond. index score2.03.13.31.81.8-1.8-1.7-1.8-1.8-1.7-1.7
Pavlov. Cond. latency score2.23.63.81.91.9-1.9-1.9-1.9-1.9-1.9-1.9
Pavlov. Cond. lever contacts1.31.92.31.51.5-1.4-1.4-1.4-1.4-1.3-1.3
Pavlov. Cond. magazine entry number0.00.00.0-0.1-0.10.10.10.20.20.20.2
Pavlov. Cond. intertrial magazine entries0.30.70.8-0.8-0.80.80.80.80.80.80.9
Pavlov. Cond. lever-magazine prob. diff.1.52.32.51.61.6-1.5-1.5-1.5-1.5-1.5-1.5
Pavlov. Cond. response bias1.21.61.71.31.3-1.3-1.2-1.3-1.3-1.3-1.2
Time in closed arm before self-admin1.01.72.5-1.2-1.61.31.61.21.21.11.2
Time in closed arm after self-admin0.70.81.40.20.6-0.9-0.4-1.1-1.1-1.2-1.2
Time in open arm before self-admin1.61.93.01.21.7-1.4-1.7-1.3-1.2-1.1-1.3
Time in open arm after self-admin0.91.01.3-0.6-1.01.10.81.11.11.11.1
Bone: periosteal estimation0.30.81.10.80.7-0.9-0.9-0.9-0.9-1.0-1.1
Bone: periosteal perimeter0.30.50.90.50.4-0.7-0.6-0.8-0.8-0.8-0.9
Bone: post-yield work0.20.40.5-0.7-0.70.60.70.50.50.50.5
Progressive ratio test 1 active lever presses0.40.61.01.00.5-0.8-0.4-0.8-0.9-0.9-0.9
Progressive ratio test 1 breakpoint0.40.71.21.10.6-0.8-0.5-0.9-0.9-1.0-1.0
Progressive ratio test 1 inactive lever presses0.92.32.91.61.1-1.5-1.1-1.6-1.6-1.7-1.7
Progressive ratio test 2 active lever presses0.30.40.60.80.6-0.6-0.6-0.6-0.6-0.6-0.6
Progressive ratio test 2 breakpoint0.30.40.60.80.6-0.6-0.6-0.6-0.6-0.6-0.6
Progressive ratio test 2 inactive lever presses0.00.10.20.30.4-0.4-0.4-0.4-0.4-0.4-0.4
Incentive Sensitization - Responses0.00.00.1-0.10.10.1-0.10.20.20.20.2
Incentive Sensitization - Breakpoint0.00.00.1-0.10.00.1-0.00.20.20.30.3
Sum of active levers in priming session hrs 5-61.51.41.7-0.9-1.21.21.01.31.31.31.2
Progressive ratio0.00.10.2-0.00.10.2-0.50.30.40.40.5
Food seeking constrained by brief footshock0.10.10.1-0.1-0.30.30.40.30.30.30.3
Seeking ratio, punishment vs. effort0.10.20.40.1-0.0-0.30.4-0.5-0.5-0.6-0.6
Retroperitoneal fat weight0.52.43.5-1.8-1.71.51.91.41.41.41.3
Reaction time number correct0.41.31.6-1.2-1.11.21.11.11.11.11.2
Reaction time mean minus median0.10.30.4-0.5-0.50.60.70.60.60.60.6
Reaction time mean minus median AUC0.42.43.3-1.6-1.71.51.81.51.51.51.4
Reaction time num false alarms4.78.18.82.93.0-2.9-2.9-2.8-2.8-2.8-2.7
Reaction time num false alarms AUC3.68.39.12.93.0-2.9-3.0-2.8-2.8-2.8-2.7
Reaction time trials correct on left0.41.31.6-1.2-1.11.21.11.11.11.11.2
Reaction time trials on left0.41.41.6-1.3-1.21.21.11.21.21.11.2
Reaction time mean0.51.01.1-1.0-1.01.01.11.01.11.10.9
Reaction time mean AUC0.30.80.9-0.8-0.90.90.90.90.90.90.8
Median of all reaction times0.40.70.8-0.8-0.80.90.90.90.90.90.7
Reaction time omissions1.11.92.2-1.4-1.51.31.51.31.31.31.3
Reaction time false alarm rate6.28.69.33.03.0-2.9-3.0-2.9-2.9-2.9-2.8
Reaction time premature initiation rate0.20.20.4-0.6-0.60.50.60.40.40.40.4
Reaction time premature initiations0.20.60.9-0.9-0.90.80.80.70.70.70.8
Std. dev. reaction times0.41.31.4-1.1-1.21.11.21.11.11.11.1
Reaction time trials completed0.41.41.6-1.3-1.21.21.11.21.21.11.2
Reaction time trials AUC0.31.11.4-1.1-1.01.11.01.11.11.01.2
Run reversals in cocaine runway, females0.10.10.4-0.6-0.20.30.50.20.20.30.3
Run reversals in cocaine runway, males0.10.10.4-0.6-0.30.20.40.20.20.1-0.1
Latency to leave start box in cocaine runway0.40.51.80.61.2-0.6-1.3-0.3-0.3-0.1-0.1
Latency to leave start box in cocaine runway, F0.10.10.40.20.6-0.2-0.60.00.10.20.2
Latency to leave start box in cocaine runway, M0.20.21.10.20.7-0.4-1.0-0.2-0.2-0.10.1
Std. dev. time between licks in bursts0.00.00.2-0.5-0.20.10.10.10.10.0-0.1
Total sessions with >9 infusions0.30.41.0-0.6-1.00.61.00.40.40.20.2
Short access day 1 total inactive lever presses2.14.25.4-2.2-2.32.12.32.01.91.81.8
Short access day 10 total inactive lever presses0.00.00.10.20.0-0.1-0.2-0.2-0.2-0.2-0.2
Short access day 1 total infusions0.30.61.4-0.5-1.20.81.10.60.60.40.4
Short access day 10 total infusions0.20.30.9-0.5-0.90.51.00.40.40.30.2
Short access total infusions0.10.20.6-0.1-0.80.30.80.10.10.0-0.0
Short access day 1 locomotion0.00.10.20.3-0.2-0.10.2-0.3-0.3-0.4-0.4
Short access day 10 total locomotion0.20.81.71.30.7-0.8-0.8-0.9-0.9-0.9-0.9
Short access total locomotion0.40.71.10.90.4-0.8-0.4-0.9-0.9-1.0-1.0
One hour access (0.3 mA shock)0.10.10.30.50.1-0.30.0-0.3-0.3-0.3-0.3
Compulsive drug intake0.71.11.3-1.0-1.11.01.11.01.01.01.0
One hour access (shock baseline)0.10.20.30.60.3-0.4-0.2-0.4-0.5-0.5-0.5
Social response proportion2.02.63.2-1.8-1.71.61.61.61.51.51.4
Social responses1.92.42.7-1.7-1.61.61.51.61.51.51.5
Social time1.32.02.9-1.5-1.71.41.61.31.31.21.1
Soleus weight2.36.77.6-2.7-2.62.62.62.62.62.52.4
Bone: stiffness1.73.03.6-1.9-1.91.81.71.71.71.71.7
Tibialis anterior weight2.89.610.9-3.3-3.23.13.03.13.13.13.0
Time to tail flick, vehicle, before self-admin0.10.10.3-0.6-0.50.20.40.10.10.00.0
Time to tail flick, vehicle, after self-admin0.30.60.90.90.5-0.7-0.5-0.8-0.8-0.8-1.0
Time to tail flick, test, before self-admin0.00.00.1-0.30.00.10.20.10.10.10.2
Time to tail flick, test, after self-admin0.40.41.40.51.2-0.5-1.0-0.3-0.3-0.20.1
Delta time to tail flick, vehicle, before/after SA0.40.51.11.00.8-0.6-0.8-0.5-0.5-0.4-0.5
Delta time to tail flick, test, before/after SA0.40.50.91.00.8-0.7-0.9-0.6-0.6-0.6-0.5
Tibia length0.00.10.10.20.1-0.3-0.2-0.3-0.3-0.3-0.4
Ambulatory time before self-admin0.72.12.80.91.3-1.6-1.3-1.6-1.6-1.7-1.5
Ambulatory time after self-admin0.00.00.1-0.3-0.20.00.1-0.0-0.0-0.0-0.0
Bone: tissue strength1.81.82.21.31.2-1.3-1.5-1.4-1.4-1.4-1.4
Total heroin consumption3.44.05.6-1.9-1.62.11.52.22.32.42.0
Bone: trabecular number2.75.05.5-2.3-2.12.32.02.32.32.32.3
Bone: trabecular spacing0.30.40.50.60.5-0.6-0.6-0.6-0.6-0.7-0.6
Bone: trabecular thickness0.00.00.0-0.0-0.0-0.0-0.1-0.1-0.1-0.1-0.1
Bone: trabecular tissue density1.11.92.21.51.4-1.4-1.2-1.4-1.4-1.4-1.3
Water consumed over 24 hours0.00.00.10.20.2-0.2-0.4-0.1-0.1-0.1-0.2
Number of responses in last shaping day1.11.41.81.11.1-1.2-1.2-1.2-1.2-1.3-1.3