Hub : Genes

Bhlha9

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Bhlha9 0.06 0.05 5.8e-03 0.06 0.03 0.03 0.03 1.2e-03 2.9e-02 1.6e-02 1.6e-02
2 Adipose gene expression Bhlha9 0.04 0.03 3.5e-05 0.03 0.03 0.03 0.03 6.2e-04 3.1e-04 4.4e-04 4.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.24.14.3-1.92.1
Area under the delay curve1.01.51.71.1-1.3
BMI with tail0.72.32.5-1.51.6
BMI without tail1.15.75.8-2.42.4
Body weight3.414.915.4-3.93.8
Weight adjusted by age0.00.00.10.3-0.1
Bone surface0.91.82.0-1.21.4
Bone volume1.02.02.2-1.31.5
Breakpoint value in progressive ratio session1.73.03.2-1.81.7
Number of licking bursts0.30.81.31.2-0.4
Context. condit. distance diff. score0.70.91.1-0.81.0
Locomotion velocity, session 12.32.62.8-1.61.7
Locomotion distance, session 10.10.20.2-0.40.4
Locomotion velocity, session 20.00.00.1-0.10.3
Locomotion distance, session 20.81.11.2-1.11.0
Locomotion velocity, session 32.02.32.51.4-1.6
Locomotion distance, session 30.40.50.60.6-0.8
Stereotopy head waving bouts, day 30.30.40.4-0.70.5
Stereotopy head waving duration, day 30.20.30.30.5-0.5
Locomotion velocity, session 70.10.10.1-0.20.3
Locomotion distance, session 70.10.10.2-0.20.4
Stereotopy head waving bouts, day 70.80.90.9-1.00.9
Stereotopy head waving duration, day 70.60.80.9-0.90.8
Locomotion velocity, session 80.00.00.0-0.10.1
Locomotion distance, session 80.91.31.5-1.01.2
Degree of sensitization distance2.02.12.5-1.31.6
Degree of sensitization stereotypy1.01.11.1-1.11.1
Conditioned locomotion0.50.50.60.7-0.8
Cocaine response after cond. corrected1.31.91.9-1.41.3
Cocaine response after cond. not corrected1.82.62.7-1.61.6
Cocaine response before conditioning0.20.20.2-0.50.5
Saline control response0.40.60.80.9-0.5
Bone: connectivity density3.75.85.9-2.42.4
Bone: cortical apparent density0.10.20.40.3-0.6
Bone: cortical area2.13.43.81.9-1.8
Bone: cortical porosity0.30.30.4-0.60.5
Bone: cortical porosity0.10.10.1-0.30.2
Bone: cortical thickness2.33.83.91.9-2.0
Bone: cortical thickness0.10.20.30.5-0.3
Bone: cortical tissue density0.10.10.20.1-0.4
Condit. Reinf. active minus inactive responses0.00.00.1-0.2-0.1
Condit. Reinf. active-inactive response ratio0.00.00.0-0.1-0.0
Condit. Reinf. active responses0.20.30.4-0.60.4
Condit. Reinf. inactive responses0.10.10.1-0.40.4
Incentive salience index mean0.10.10.1-0.40.2
Condit. Reinf. lever presses0.60.90.9-1.00.9
Condit. Reinf. active minus inactive responses0.00.00.10.2-0.2
Condit. Reinf. active-inactive response ratio0.00.10.10.3-0.2
Condit. Reinf. active responses0.10.20.20.5-0.4
Condit. Reinf. inactive responses0.10.10.20.4-0.3
Condit. Reinf. lever presses1.72.42.71.4-1.7
Condit. Reinf. lever reinforcers received0.30.40.40.6-0.6
Conditioned reinforcement - actives0.00.10.2-0.20.4
Conditioned reinforcement - inactives0.00.10.20.4-0.1
Conditioned locomotion0.10.10.20.3-0.4
Patch foraging indifference point 0 sec0.00.10.20.3-0.4
Patch foraging indifference point AUC1.22.93.41.8-1.5
Delay disc. indifference point, 0s delay0.80.81.21.1-0.7
Delay disc. indifference point, 16s delay0.71.01.40.8-1.2
Delay disc. indifference point, 2s delay2.02.22.61.6-1.4
Delay disc. indifference point, 24s delay0.00.00.00.10.0
Delay disc. indifference point, 4s delay0.10.10.10.4-0.1
Delay disc. indifference point, 8s delay0.20.40.60.4-0.8
Indifference point function ln k0.61.72.1-1.51.1
Indifference point function log k0.61.72.1-1.51.1
Patch foraging total patch changes 0 sec0.10.20.20.4-0.4
Patch foraging total patch changes 12 sec0.50.70.80.9-0.7
Patch foraging total patch changes 18 sec0.40.91.01.0-0.9
Patch foraging total patch changes 24 sec0.41.51.61.2-1.3
Patch foraging total patch changes 6 sec2.94.95.52.3-2.1
Patch foraging time to switch 0 sec0.31.31.3-1.11.1
Patch foraging water rate 0 sec0.93.33.61.9-1.7
Patch foraging water rate 12 sec0.00.00.0-0.10.2
Patch foraging water rate 18 sec0.20.50.6-0.60.7
Patch foraging water rate 24 sec0.71.01.21.1-0.9
Patch foraging water rate 6 sec1.21.81.91.4-1.3
Seeking ratio, delayed vs. immediate footshock2.63.73.92.0-1.9
Distance traveled before self-admin2.04.34.62.0-2.1
Distance traveled after self-admin0.20.30.50.7-0.3
Extensor digitorum longus weight0.62.52.7-1.51.6
Bone: elastic displacement1.31.71.81.2-1.3
Bone: elastic work4.76.16.52.4-2.5
Bone: endosteal estimation0.30.81.11.1-0.6
Bone: endosteal perimeter0.20.50.70.9-0.5
Epididymis fat weight5.125.827.1-5.05.2
Delta time in closed arm before/after self-admin1.51.41.61.3-1.1
Delta time in open arm before/after self-admin2.22.52.8-1.71.5
Diff in mean of infusions in LGA sessions0.71.21.6-1.01.2
Delay discount exponential model param0.70.91.1-0.91.1
Extinction: sum of active levers before priming0.81.21.3-1.21.0
Active lever presses in extinction session 61.31.31.8-1.40.9
Bone: final force0.40.60.60.8-0.7
Bone: final moment0.40.70.70.8-0.8
Food consumed during 24 hour testing period0.10.10.3-0.50.1
Glucose1.82.83.01.6-1.7
Heart weight1.93.03.1-1.71.8
Delay discount hyperbolic model param0.91.21.4-1.01.2
Intermittent access intake day 1-15 change0.10.40.40.6-0.6
Intermittent access intake escalation0.00.30.30.5-0.6
Intermittent access intake escalation 20.71.21.41.2-1.0
Intermitt. access day 1 inactive lever presses0.11.41.81.1-1.3
Intermitt. access day 15 inactive lever presses0.42.22.21.5-1.5
Intermitt. access escalation Index0.82.62.9-1.51.7
Intermittent access day 1 total infusions0.00.00.0-0.0-0.0
Intermittent access day 15 total infusions0.00.00.00.2-0.1
Intermittent access terminal intake (last 3 days)0.00.10.1-0.10.4
Intermittent access total infusions0.10.10.10.3-0.3
Intermittent access day 1 locomotion0.20.30.40.6-0.5
Intermittent access day 15 total locomotion0.00.10.10.3-0.3
Intermittent access total locomotion0.10.10.10.3-0.3
Intermittent access standard deviation0.21.01.20.8-1.1
Left kidney weight0.00.40.5-0.70.5
Right kidney weight0.10.91.1-1.10.9
Cocaine induced anxiety0.00.00.00.2-0.2
Post-drug Anxiety1.61.81.9-1.41.3
Baseline Anxiety0.91.41.6-1.11.2
Tail length1.36.97.1-2.72.6
Length with tail2.08.89.1-3.02.9
Length without tail0.73.63.9-2.01.8
Times rat made contact with spout0.30.30.6-0.8-0.1
Lifetime Intake0.00.00.0-0.0-0.2
Liver weight, left6.711.512.2-3.33.5
Liver weight, right7.413.013.5-3.73.5
Locomotor activity0.00.00.00.1-0.0
Locomotor testing distance0.10.30.40.6-0.3
Locomotor testing rearing0.10.20.30.6-0.3
Locomotion in novel chamber3.44.65.22.0-2.3
Locomotion in novel chamber post-restriction0.00.10.2-0.50.1
Fecal boli incidents, locomotor time 10.30.70.9-0.71.0
Change in fecal boli incidents, locomotor task0.20.20.40.6-0.3
Time >=10cm from walls, locomotor time 10.10.10.10.3-0.4
Bouts of movement, locomotor time 10.30.30.40.6-0.5
Total resting periods, locomotor time 10.30.40.50.7-0.4
Rest time, locomotor task time 10.20.30.60.7-0.1
Distance moved, locomotor task time 10.00.00.10.0-0.3
Vertical activity count, locomotor time 10.00.00.0-0.20.1
Time >=10cm from walls, locomotor time 20.10.40.70.8-0.3
Bouts of movement, locomotor time 20.10.30.50.7-0.3
Total resting periods, locomotor time 20.00.00.10.20.1
Rest time, locomotor task time 20.00.10.1-0.00.3
Distance moved, locomotor task time 20.30.30.50.4-0.7
Vertical activity count, locomotor time 20.20.40.40.7-0.6
Light reinforcement 10.00.00.0-0.1-0.0
Light reinforcement 20.20.40.50.6-0.7
Bone: marrow area0.30.81.21.1-0.7
Bone: maximum diameter1.22.52.91.7-1.4
Bone: maximum force0.71.41.51.2-1.1
Bone: maximum moment0.81.61.71.3-1.2
Mean time between licks in bursts0.20.91.1-0.91.0
Mean num. licks in bursts0.61.52.9-1.70.4
Cd content in liver1.01.22.11.4-0.5
Co content in liver0.10.20.20.3-0.5
Cu content in liver1.11.31.61.0-1.3
Fe content in liver1.21.51.5-1.21.2
K content in liver0.60.61.0-1.00.5
Mg content in liver0.40.40.50.7-0.6
Mn content in liver0.10.10.20.4-0.4
Na content in liver0.10.10.1-0.3-0.3
Rb content in liver0.10.10.10.30.2
Se content in liver0.60.81.01.0-0.7
Sr content in liver0.30.20.3-0.60.4
Zn content in liver0.20.30.5-0.30.7
Bone: minimum diameter0.30.60.80.9-0.6
Time in familiar zone, hab. session 10.40.50.50.7-0.7
Time in novel zone, hab. session 10.10.10.2-0.30.4
Total zone transitions, hab. session 10.00.00.10.2-0.3
Total locomotion distance, hab. session 10.00.10.1-0.20.2
Locomotion velocity, hab. session 10.00.00.00.1-0.1
Time in familiar zone, hab. session 20.00.00.10.2-0.1
Time in novel zone, hab. session 20.20.20.30.4-0.6
Total zone transitions, hab. session 20.70.91.0-1.00.8
Total locomotion distance, hab. session 20.30.40.5-0.70.5
Locomotion velocity, hab. session 20.20.30.4-0.60.4
Novel to familiar place preference ratio0.00.00.00.1-0.1
Novelty place preference0.00.00.0-0.20.2
Time in novel zone, NPP test0.10.10.1-0.30.3
Total zone transitions, NPP test0.10.10.2-0.40.2
Total locomotion distance, NPP test0.20.20.30.4-0.5
Locomotion velocity, NPP test0.40.60.70.7-0.8
Intraocular pressure1.42.22.31.5-1.5
Delta distance traveled before/after self-admin2.42.62.9-1.51.7
Delta ambulatory time before/after self-admin1.22.12.4-1.41.5
Parametrial fat weight7.617.918.9-4.14.3
Pavlov. Cond. lever latency0.00.00.00.2-0.1
Pavlov. Cond. magazine entry latency0.60.80.9-1.00.8
Pavlov. Cond. change in total contacts0.20.20.30.5-0.5
Pavlov. Cond. index score0.30.30.4-0.60.5
Pavlov. Cond. latency score0.30.40.5-0.70.6
Pavlov. Cond. lever contacts0.00.00.1-0.30.2
Pavlov. Cond. magazine entry number0.10.20.30.5-0.3
Pavlov. Cond. intertrial magazine entries0.20.20.20.5-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.50.4
Pavlov. Cond. response bias0.30.40.5-0.70.5
Pavlov. Cond. lever latency1.82.62.9-1.51.7
Pavlov. Cond. magazine entry latency0.10.10.2-0.4-0.1
Pavlov. Cond. change in total contacts0.82.12.21.4-1.5
Pavlov. Cond. index score1.32.12.51.3-1.6
Pavlov. Cond. latency score1.62.53.01.5-1.7
Pavlov. Cond. lever contacts0.81.11.31.0-1.2
Pavlov. Cond. magazine entry number0.00.00.00.20.2
Pavlov. Cond. intertrial magazine entries0.20.40.6-0.50.8
Pavlov. Cond. lever-magazine prob. diff.1.11.72.11.2-1.4
Pavlov. Cond. response bias0.60.81.00.8-1.0
Time in closed arm before self-admin0.71.21.6-0.91.2
Time in closed arm after self-admin0.80.91.11.1-0.9
Time in open arm before self-admin1.62.02.21.3-1.5
Time in open arm after self-admin0.20.20.4-0.60.0
Bone: periosteal estimation1.12.53.11.8-1.4
Bone: periosteal perimeter0.81.72.01.4-1.2
Bone: post-yield work0.20.40.5-0.60.7
Progressive ratio test 1 active lever presses0.40.70.70.8-0.9
Progressive ratio test 1 breakpoint0.40.70.80.8-0.9
Progressive ratio test 1 inactive lever presses2.05.15.52.3-2.2
Progressive ratio test 2 active lever presses0.60.91.00.9-1.0
Progressive ratio test 2 breakpoint0.70.80.90.9-0.9
Progressive ratio test 2 inactive lever presses0.31.11.50.8-1.2
Incentive Sensitization - Responses0.00.10.10.2-0.3
Incentive Sensitization - Breakpoint0.00.00.00.1-0.2
Sum of active levers in priming session hrs 5-63.53.33.8-2.01.7
Progressive ratio0.10.20.30.3-0.5
Food seeking constrained by brief footshock0.00.00.0-0.20.2
Seeking ratio, punishment vs. effort0.00.00.00.20.1
Retroperitoneal fat weight0.52.22.4-1.41.5
Reaction time number correct0.10.20.2-0.40.5
Reaction time mean minus median0.10.50.8-0.90.5
Reaction time mean minus median AUC0.31.82.3-1.51.2
Reaction time num false alarms3.05.05.22.3-2.2
Reaction time num false alarms AUC2.45.55.72.4-2.3
Reaction time trials correct on left0.10.20.2-0.40.5
Reaction time trials on left0.10.20.2-0.40.5
Reaction time mean0.40.91.1-1.00.8
Reaction time mean AUC0.20.50.6-0.80.6
Median of all reaction times0.30.40.5-0.70.6
Reaction time omissions1.42.23.0-1.71.2
Reaction time false alarm rate3.34.64.72.2-2.1
Reaction time premature initiation rate0.10.20.3-0.50.4
Reaction time premature initiations0.10.20.3-0.50.5
Std. dev. reaction times0.30.91.4-1.20.7
Reaction time trials completed0.10.20.2-0.40.5
Reaction time trials AUC0.00.10.2-0.30.4
Run reversals in cocaine runway, females0.10.10.1-0.30.1
Run reversals in cocaine runway, males0.10.10.1-0.40.2
Latency to leave start box in cocaine runway0.00.00.0-0.1-0.0
Latency to leave start box in cocaine runway, F0.20.30.4-0.60.4
Latency to leave start box in cocaine runway, M0.20.20.30.5-0.4
Std. dev. time between licks in bursts0.00.10.10.2-0.3
Total sessions with >9 infusions0.00.00.00.0-0.2
Short access day 1 total inactive lever presses0.61.11.5-1.20.9
Short access day 10 total inactive lever presses0.21.21.31.1-1.0
Short access day 1 total infusions0.10.20.30.4-0.6
Short access day 10 total infusions0.00.00.1-0.3-0.0
Short access total infusions0.20.20.40.3-0.6
Short access day 1 locomotion0.50.91.20.8-1.1
Short access day 10 total locomotion0.51.92.01.4-1.4
Short access total locomotion1.72.62.71.5-1.7
One hour access (0.3 mA shock)0.00.00.00.1-0.2
Compulsive drug intake1.92.93.6-1.91.5
One hour access (shock baseline)0.30.91.11.1-0.8
Social response proportion3.44.34.5-2.12.0
Social responses1.41.82.0-1.31.4
Social time1.52.32.6-1.41.6
Soleus weight3.710.811.0-3.33.3
Bone: stiffness0.50.91.1-0.81.1
Tibialis anterior weight2.58.58.8-2.93.0
Time to tail flick, vehicle, before self-admin0.30.30.4-0.50.6
Time to tail flick, vehicle, after self-admin0.00.00.10.3-0.1
Time to tail flick, test, before self-admin0.10.10.1-0.30.3
Time to tail flick, test, after self-admin0.00.00.00.1-0.0
Delta time to tail flick, vehicle, before/after SA0.10.10.20.3-0.4
Delta time to tail flick, test, before/after SA0.50.60.70.8-0.7
Tibia length0.30.71.0-1.00.7
Ambulatory time before self-admin0.82.32.71.4-1.6
Ambulatory time after self-admin0.10.10.1-0.20.4
Bone: tissue strength0.60.60.90.6-0.9
Total heroin consumption5.56.56.6-2.62.5
Bone: trabecular number3.15.85.9-2.42.4
Bone: trabecular spacing0.50.80.80.8-0.9
Bone: trabecular thickness0.00.00.00.20.0
Bone: trabecular tissue density1.01.81.91.3-1.4
Water consumed over 24 hours0.10.20.3-0.50.3
Number of responses in last shaping day1.52.02.31.3-1.5