Barx2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Barx2	0.09	0.06	5.5e-09	0.07	0.05	0.06	0.06	4.0e-08	1.2e-06	2.5e-07	7.5e-08
2	BLA	gene expression	Barx2	0.21	0.1	7.3e-09	0.15	0.16	0.16	0.16	1.4e-08	7.4e-09	5.1e-09	7.4e-09
3	pVTA	gene expression	Barx2	0.14	0.12	5.7e-05	0.1	0.1	0.11	0.08	4.0e-05	5.8e-05	1.4e-05	3.6e-04
4	NAcc	mRNA stability	Barx2	0.05	0.03	2.0e-05	0.04	0.04	0.04	0.04	2.0e-05	3.5e-05	1.6e-05	4.5e-05
5	Brain	mRNA stability	Barx2	0.05	0.04	1.6e-04	0.04	0.04	0.04	0.04	6.4e-05	2.1e-04	2.4e-04	9.8e-05
6	PL	gene expression	Barx2	0.07	0.05	2.3e-04	0.04	0.03	0.03	0.03	8.7e-05	1.7e-04	8.7e-04	1.8e-04
7	LHb	gene expression	Barx2	0.11	0.09	5.4e-03	0.1	0.07	0.09	0.11	1.8e-03	8.4e-03	4.4e-03	1.7e-03
8	BLA	mRNA stability	Barx2	0.06	0.04	1.1e-03	0.05	0.05	0.05	0.04	7.8e-04	9.6e-04	9.4e-04	2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.1	0.3	0.4	0.1	0.3	0.3	-0.3	-0.0	-0.5	-0.5
Area under the delay curve	0.3	0.3	0.5	0.5	0.3	0.7	0.7	-0.5	-0.6	-0.4	0.1
BMI with tail	0.3	0.9	2.8	0.5	0.6	0.4	1.7	0.2	-1.2	-0.1	1.4
BMI without tail	0.2	0.5	1.2	-0.3	-0.5	-1.0	0.7	1.0	0.2	1.1	-0.0
Body weight	0.2	0.9	2.3	0.3	0.7	1.1	0.7	-0.7	-1.4	-0.5	1.5
Weight adjusted by age	0.3	0.3	0.8	-0.3	-0.4	0.7	0.5	0.1	-0.9	0.1	-0.8
Bone surface	0.0	0.1	0.1	0.3	0.1	0.4	0.0	-0.1	-0.0	-0.3	-0.3
Bone volume	0.4	0.6	1.2	0.9	0.6	0.9	0.8	-0.8	-0.6	-1.1	-0.1
Breakpoint value in progressive ratio session	1.2	1.3	2.6	0.9	1.0	0.9	1.3	-1.6	-1.2	-1.2	0.8
Number of licking bursts	0.1	0.1	0.5	-0.0	0.0	0.1	0.7	-0.4	-0.3	-0.5	-0.0
Context. condit. distance diff. score	0.3	0.4	1.9	-0.6	-0.4	-0.5	-0.4	0.3	0.5	0.1	-1.4
Locomotion velocity, session 1	0.7	0.7	1.9	0.7	0.5	1.3	1.1	-0.5	-1.4	-0.3	0.4
Locomotion distance, session 1	1.5	2.0	3.5	1.5	1.3	1.9	1.4	-1.3	-1.6	-1.3	0.8
Locomotion velocity, session 2	4.5	5.2	7.1	2.6	2.3	2.6	2.0	-2.3	-2.7	-2.1	1.4
Locomotion distance, session 2	4.9	6.9	9.8	2.9	2.6	3.1	2.2	-2.5	-2.8	-2.4	2.2
Locomotion velocity, session 3	1.0	1.2	2.0	1.2	0.9	1.3	1.1	-1.1	-1.4	-0.9	0.4
Locomotion distance, session 3	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.1	-0.1	-0.2	0.0	0.2
Stereotopy head waving bouts, day 3	3.7	4.3	6.5	-2.1	-2.1	-1.6	-2.5	2.5	1.8	2.1	-1.7
Stereotopy head waving duration, day 3	4.2	5.0	6.4	-2.3	-2.3	-1.8	-2.4	2.5	1.9	2.3	-2.3
Locomotion velocity, session 7	0.6	0.6	2.6	-0.6	-0.7	-0.6	-0.6	0.5	0.6	0.5	-1.6
Locomotion distance, session 7	0.7	0.9	2.1	-0.7	-0.9	-0.9	-0.7	1.0	0.8	0.8	-1.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.4	0.2	-0.2	-0.0	-0.1
Stereotopy head waving duration, day 7	0.1	0.1	0.5	-0.4	-0.2	0.2	-0.7	0.3	0.1	0.2	-0.2
Locomotion velocity, session 8	1.5	1.7	2.5	1.4	1.3	1.5	1.6	-1.3	-1.4	-1.3	0.3
Locomotion distance, session 8	2.1	3.0	4.5	1.7	1.9	2.1	1.4	-1.8	-1.9	-1.9	0.9
Degree of sensitization distance	0.1	0.1	0.4	0.2	0.1	-0.1	0.1	0.2	0.1	0.0	-0.7
Degree of sensitization stereotypy	0.6	0.6	1.1	0.7	0.8	1.0	0.6	-0.8	-0.9	-0.9	0.5
Conditioned locomotion	0.1	0.1	0.4	0.4	0.4	0.0	0.1	-0.2	-0.3	-0.1	0.6
Cocaine response after cond. corrected	0.8	0.8	1.1	0.8	1.0	1.0	1.1	-0.9	-1.1	-0.7	0.8
Cocaine response after cond. not corrected	2.1	2.3	3.1	1.4	1.5	1.7	1.6	-1.4	-1.7	-1.4	1.3
Cocaine response before conditioning	0.3	0.4	0.8	0.5	0.5	0.9	0.3	-0.6	-0.6	-0.8	0.5
Saline control response	0.1	0.1	0.3	0.4	0.3	-0.3	-0.1	0.2	0.4	-0.1	0.6
Bone: connectivity density	0.2	0.4	0.7	-0.4	-0.5	-0.4	-0.8	0.5	0.8	0.3	-0.8
Bone: cortical apparent density	1.0	1.3	2.8	-1.0	-1.3	-1.0	-1.0	1.2	0.7	1.2	-1.7
Bone: cortical area	0.1	0.1	0.3	0.1	-0.5	-0.4	0.2	0.5	0.3	0.4	-0.6
Bone: cortical porosity	0.5	0.5	1.2	0.7	0.6	0.4	1.1	-0.7	-0.6	-0.9	-0.0
Bone: cortical porosity	0.3	0.3	0.7	0.6	0.5	0.2	0.8	-0.5	-0.4	-0.7	-0.1
Bone: cortical thickness	0.5	0.8	1.6	-0.3	-0.8	-1.2	-0.7	1.0	1.3	0.8	-0.5
Bone: cortical thickness	0.3	0.4	1.0	-0.3	-0.5	-0.5	-0.6	0.3	0.9	0.3	-1.0
Bone: cortical tissue density	1.0	1.3	2.8	-0.9	-1.3	-0.9	-1.0	1.2	0.6	1.2	-1.7
Condit. Reinf. active minus inactive responses	3.7	4.1	5.1	2.2	2.2	2.3	1.9	-2.1	-2.1	-2.0	1.0
Condit. Reinf. active-inactive response ratio	2.8	3.0	3.9	1.9	1.9	2.0	1.6	-1.9	-1.8	-1.8	0.6
Condit. Reinf. active responses	1.3	1.5	2.1	1.4	1.2	1.3	1.4	-1.2	-1.5	-1.1	0.6
Condit. Reinf. inactive responses	0.8	0.9	1.5	-1.0	-1.2	-1.2	-0.5	1.2	0.6	1.1	-0.2
Incentive salience index mean	2.9	3.5	4.5	2.1	2.0	1.9	1.9	-1.9	-1.9	-1.8	1.4
Condit. Reinf. lever presses	0.9	1.2	2.1	1.0	0.8	1.2	1.3	-0.8	-1.4	-0.6	1.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	0.8	0.9	-0.1	-0.0	-0.9	0.4	-0.8	0.6
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.7	-0.7	-0.7	-1.7	-1.2	0.9	1.6	1.1	-0.9
Condit. Reinf. active responses	1.5	2.1	3.3	1.6	1.8	1.0	1.1	-1.8	-0.7	-1.7	1.5
Condit. Reinf. inactive responses	3.5	4.3	5.3	2.0	2.1	2.1	2.1	-2.1	-1.9	-2.3	2.0
Condit. Reinf. lever presses	3.9	5.4	8.0	2.7	2.7	2.0	1.7	-2.3	-1.4	-2.5	2.8
Condit. Reinf. lever reinforcers received	1.7	2.3	3.7	1.8	1.9	1.1	1.1	-1.9	-0.8	-1.8	1.4
Conditioned reinforcement - actives	1.1	1.1	2.2	1.2	1.1	0.1	-0.8	-1.5	0.6	-0.9	1.3
Conditioned reinforcement - inactives	0.5	0.5	0.9	0.8	0.8	0.9	0.0	-0.7	-0.6	-0.6	1.0
Conditioned locomotion	1.4	1.7	3.6	1.4	1.5	1.2	0.4	-1.9	-0.5	-1.4	1.5
Patch foraging indifference point 0 sec	0.2	0.4	1.3	0.9	0.5	0.7	0.1	-0.5	0.1	-0.1	1.1
Patch foraging indifference point AUC	0.1	0.1	0.4	0.3	-0.2	-0.4	0.5	0.4	-0.2	0.3	0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.4	0.1	0.1	0.2	0.7	-0.2	-0.1	-0.1	0.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.3	0.3	-0.2	-0.3	-0.1	0.5	-0.2	0.0
Delay disc. indifference point, 2s delay	1.5	1.6	2.5	1.4	1.1	1.1	1.6	-1.4	-1.2	-1.2	1.1
Delay disc. indifference point, 24s delay	0.9	0.9	1.9	0.8	0.8	1.0	1.2	-0.7	-1.4	-0.8	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.3	0.1	0.1	-0.1	-0.3	0.3	-0.1	0.5
Delay disc. indifference point, 8s delay	0.2	0.2	0.8	-0.3	-0.6	0.2	0.2	0.3	-0.3	0.4	-0.9
Indifference point function ln k	0.1	0.1	0.3	0.0	0.4	0.3	-0.2	-0.6	0.3	-0.1	0.1
Indifference point function log k	0.1	0.1	0.3	0.0	0.4	0.3	-0.2	-0.6	0.3	-0.1	0.1
Patch foraging total patch changes 0 sec	0.2	0.4	1.1	1.0	0.5	0.7	0.3	-0.4	-0.1	-0.1	1.1
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	0.1	-0.4	-0.3	0.0	0.7	-0.1	0.7	0.6
Patch foraging total patch changes 18 sec	1.4	1.8	3.9	1.5	1.0	1.0	1.8	-0.9	-1.3	-1.0	2.0
Patch foraging total patch changes 24 sec	0.2	0.2	0.6	0.4	-0.2	-0.4	0.3	0.4	0.2	0.6	0.8
Patch foraging total patch changes 6 sec	0.3	0.5	1.0	-0.4	-0.7	-0.8	-0.6	0.7	0.6	1.0	0.5
Patch foraging time to switch 0 sec	0.1	0.2	0.8	-0.9	-0.3	-0.3	-0.6	0.3	0.3	0.1	-0.1
Patch foraging water rate 0 sec	0.7	1.0	2.0	1.4	0.8	1.0	1.3	-0.4	-1.1	-0.5	1.2
Patch foraging water rate 12 sec	0.2	0.3	0.6	0.6	0.7	0.4	0.8	-0.6	-0.6	-0.4	0.5
Patch foraging water rate 18 sec	0.3	0.4	0.9	0.9	0.6	0.9	0.4	-0.6	-0.4	-0.4	0.2
Patch foraging water rate 24 sec	0.6	0.8	2.3	1.5	1.0	0.4	0.8	-0.8	-0.2	-1.1	0.9
Patch foraging water rate 6 sec	1.0	1.5	3.3	1.3	1.1	1.1	1.8	-0.9	-1.3	-1.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.5	0.4	0.5	0.2	-0.2	-0.1	0.6	-0.3	0.7
Distance traveled before self-admin	1.0	1.1	2.3	1.4	1.3	0.7	0.4	-0.9	-0.2	-1.1	1.5
Distance traveled after self-admin	1.5	1.7	3.6	1.3	1.5	1.0	1.2	-1.1	-1.0	-1.2	1.9
Extensor digitorum longus weight	0.1	0.3	0.9	-0.4	-0.6	-0.3	-0.9	0.5	0.6	0.6	-0.4
Bone: elastic displacement	0.3	0.3	0.5	-0.4	-0.5	-0.7	-0.7	0.4	0.5	0.4	-0.6
Bone: elastic work	0.1	0.1	0.2	0.4	0.2	-0.3	-0.1	-0.2	0.5	-0.2	0.0
Bone: endosteal estimation	0.2	0.5	1.1	0.5	0.5	0.8	1.0	-0.6	-1.0	-0.6	-0.4
Bone: endosteal perimeter	0.2	0.4	0.8	0.4	0.3	0.8	0.9	-0.7	-0.7	-0.5	0.3
Epididymis fat weight	0.2	0.5	2.3	0.1	0.0	0.5	1.2	0.1	-1.5	-0.1	0.3
Delta time in closed arm before/after self-admin	0.8	0.8	1.5	0.8	0.6	1.0	1.2	-0.9	-1.2	-0.7	0.5
Delta time in open arm before/after self-admin	0.6	0.6	1.1	-0.8	-1.0	-1.0	-0.5	0.5	0.7	0.7	-0.8
Diff in mean of infusions in LGA sessions	0.3	0.3	0.9	0.5	0.6	-0.1	0.3	-0.8	0.2	-0.5	0.9
Delay discount exponential model param	0.5	0.5	0.8	-0.7	-0.5	-0.9	-0.8	0.7	0.8	0.6	-0.3
Extinction: sum of active levers before priming	0.8	0.8	2.0	-0.7	-1.0	-1.1	-0.4	0.5	0.8	0.8	-1.4
Active lever presses in extinction session 6	1.2	1.2	2.4	-0.8	-0.9	-1.2	-1.6	1.1	1.1	1.0	-0.9
Bone: final force	0.3	0.5	0.8	-0.4	-0.7	-0.8	-0.3	0.7	0.8	0.6	-0.9
Bone: final moment	0.3	0.5	0.9	-0.3	-0.8	-0.8	-0.1	0.8	0.7	0.7	-1.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.2	0.2	-0.2	-0.1	-0.4	0.4	-0.3	0.2
Glucose	0.1	0.1	0.3	0.3	0.4	0.4	-0.6	-0.1	-0.1	-0.1	0.3
Heart weight	1.0	1.5	5.5	-0.3	-0.3	-1.1	-2.0	-0.4	2.3	0.1	-0.8
Delay discount hyperbolic model param	0.5	0.5	0.9	-0.7	-0.5	-0.9	-0.8	0.8	0.8	0.6	-0.3
Intermittent access intake day 1-15 change	0.3	0.3	0.7	0.9	0.4	0.5	-0.2	-0.5	0.1	-0.5	0.5
Intermittent access intake escalation	0.3	0.3	0.9	0.9	0.5	0.5	-0.1	-0.6	0.2	-0.6	0.7
Intermittent access intake escalation 2	1.2	1.2	3.3	-0.6	-0.9	-0.8	-1.8	0.8	1.6	0.9	-0.7
Intermitt. access day 1 inactive lever presses	0.2	0.3	0.8	-0.2	-0.2	-0.8	-0.5	0.9	0.5	0.4	0.0
Intermitt. access day 15 inactive lever presses	1.3	1.4	1.7	1.3	1.3	1.3	0.8	-1.1	-1.1	-1.3	1.2
Intermitt. access escalation Index	0.8	0.7	1.2	1.1	0.8	0.6	1.0	-1.0	-0.5	-1.0	0.5
Intermittent access day 1 total infusions	0.5	0.6	0.9	0.8	0.7	0.8	0.3	-0.9	-0.6	-0.7	0.9
Intermittent access day 15 total infusions	0.3	0.4	0.8	0.9	0.5	0.4	-0.4	-0.9	0.3	-0.6	0.8
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.4	0.5	0.1	0.6	-0.6	-0.5	-0.0	-0.3	0.4
Intermittent access total infusions	0.6	0.6	1.1	0.9	0.7	1.1	0.1	-1.0	-0.6	-0.8	0.8
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.3	0.3	0.5	0.1	-0.3	-0.4	-0.3	0.5
Intermittent access day 15 total locomotion	0.1	0.1	0.4	0.1	0.0	-0.2	-0.6	-0.0	0.5	0.0	0.2
Intermittent access total locomotion	0.1	0.2	0.4	0.4	0.4	0.4	-0.3	-0.4	0.1	-0.3	0.7
Intermittent access standard deviation	1.7	1.8	4.4	-1.0	-1.3	-0.9	-2.1	1.0	1.8	1.2	-0.9
Left kidney weight	0.1	0.2	1.1	-0.2	-0.2	0.2	-1.0	-0.1	0.5	-0.0	0.4
Right kidney weight	0.3	0.9	2.6	-1.0	-1.0	-0.4	-1.6	1.0	0.9	0.9	0.3
Cocaine induced anxiety	2.6	3.0	5.2	1.5	1.5	2.3	1.1	-2.1	-1.7	-1.8	1.7
Post-drug Anxiety	1.4	1.6	2.2	1.2	1.2	1.4	0.9	-1.4	-1.0	-1.3	1.5
Baseline Anxiety	1.2	1.3	2.4	-1.0	-1.1	-1.5	-0.2	1.4	0.8	1.3	-1.1
Tail length	0.2	0.5	0.8	-0.7	-0.6	-0.4	-0.9	0.3	0.5	0.8	-0.9
Length with tail	0.2	0.8	2.2	0.2	0.7	1.5	-0.6	-1.2	-1.0	-0.8	0.5
Length without tail	0.8	1.7	3.6	0.7	1.2	1.9	-0.3	-1.6	-1.3	-1.5	1.3
Times rat made contact with spout	0.2	0.2	0.4	0.5	0.3	-0.1	0.6	-0.6	-0.4	-0.5	0.1
Lifetime Intake	0.7	0.8	1.4	1.0	0.8	1.2	-0.0	-1.0	-0.7	-0.9	0.9
Liver weight, left	0.3	0.5	1.3	-1.2	-0.7	-0.0	0.1	0.7	-0.6	0.8	-0.7
Liver weight, right	0.8	1.3	4.5	0.7	0.7	0.8	2.1	-0.8	-1.7	-0.9	0.2
Locomotor activity	0.2	0.3	0.8	0.9	0.5	0.4	0.6	-0.9	0.3	-0.6	0.1
Locomotor testing distance	0.3	0.5	1.8	1.3	0.6	0.8	0.7	-0.7	0.0	-0.6	-0.1
Locomotor testing rearing	0.3	0.4	0.9	1.0	0.5	0.4	0.7	-0.8	0.3	-0.8	-0.4
Locomotion in novel chamber	0.0	0.0	0.1	0.0	-0.0	-0.2	0.3	0.2	0.0	0.1	-0.2
Locomotion in novel chamber post-restriction	3.5	4.2	8.8	-2.3	-2.3	-0.8	-1.3	3.0	0.2	2.5	-2.4
Fecal boli incidents, locomotor time 1	0.3	0.4	0.8	0.5	0.4	0.9	0.2	-0.7	-0.6	-0.6	0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	0.2	0.6	0.0	0.2	-0.3	0.0	-0.4	0.4
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.2	-0.5	-0.7	-1.1	-0.8	0.7	0.9	0.7	-0.3
Bouts of movement, locomotor time 1	0.5	0.5	1.1	-1.1	-1.0	-0.0	0.3	0.6	-0.7	0.7	-0.8
Total resting periods, locomotor time 1	0.8	0.8	1.5	-1.1	-1.1	0.1	0.7	0.6	-1.2	0.8	-1.1
Rest time, locomotor task time 1	1.5	1.6	2.9	-1.7	-1.4	-1.1	-0.6	1.5	0.3	1.5	-1.5
Distance moved, locomotor task time 1	0.3	0.3	1.3	-0.3	-0.2	-0.4	-1.2	0.4	0.7	0.3	-0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.0	-0.0	-0.3	-0.1	0.2	0.2	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.2	0.2	1.0	0.1	-0.0	-0.6	-0.4	-0.2	1.0	-0.1	0.3
Bouts of movement, locomotor time 2	0.7	0.8	2.1	0.8	0.6	0.9	0.8	-0.8	-1.5	-0.8	0.2
Total resting periods, locomotor time 2	0.8	0.9	2.4	0.9	0.6	0.9	1.0	-0.9	-1.5	-0.8	0.3
Rest time, locomotor task time 2	0.4	0.4	0.8	-0.8	-0.9	-0.7	-0.1	0.7	-0.1	0.9	-0.5
Distance moved, locomotor task time 2	2.1	2.5	4.6	-1.3	-1.2	-1.7	-2.1	1.4	2.1	1.2	-1.1
Vertical activity count, locomotor time 2	1.2	1.3	2.0	-1.3	-0.9	-0.9	-1.4	1.4	0.9	1.1	-1.0
Light reinforcement 1	0.3	0.5	1.5	-0.3	-0.5	-1.0	-0.8	0.4	1.2	0.3	0.6
Light reinforcement 2	0.1	0.2	0.5	-0.7	-0.7	-0.5	-0.0	0.5	0.1	0.2	-0.0
Bone: marrow area	0.2	0.4	0.8	0.4	0.4	0.7	0.9	-0.6	-0.9	-0.5	-0.5
Bone: maximum diameter	0.1	0.2	0.7	-0.2	-0.4	0.1	0.0	0.3	-0.2	0.5	-0.8
Bone: maximum force	0.1	0.1	0.3	0.6	0.2	0.2	0.6	-0.2	-0.2	-0.4	-0.2
Bone: maximum moment	0.1	0.2	0.6	0.7	0.2	0.3	0.8	-0.2	-0.3	-0.4	-0.2
Mean time between licks in bursts	0.8	1.1	3.5	0.4	0.2	1.2	1.9	-0.2	-1.9	-0.3	-0.4
Mean num. licks in bursts	0.1	0.2	0.4	0.0	-0.3	-0.4	-0.6	0.5	0.3	0.6	-0.2
Cd content in liver	0.3	0.3	1.2	-0.1	-0.4	-0.4	-0.4	0.3	0.5	0.6	-1.1
Co content in liver	0.5	0.6	1.3	-0.9	-1.0	-0.5	-0.1	1.0	0.0	1.1	-0.7
Cu content in liver	0.2	0.3	1.3	-0.2	-0.6	-0.2	0.2	0.5	-0.2	0.4	-1.1
Fe content in liver	1.1	1.3	2.5	-0.8	-1.0	-1.1	-1.3	0.9	1.5	0.8	-1.6
K content in liver	0.8	0.8	1.8	-1.3	-1.2	-0.6	-0.5	1.2	-0.0	1.1	-0.3
Mg content in liver	1.6	1.6	3.3	-1.8	-1.6	-1.0	-0.9	1.5	0.4	1.5	-0.6
Mn content in liver	0.1	0.2	0.6	-0.5	-0.4	-0.1	-0.8	0.4	0.1	0.2	-0.1
Na content in liver	0.3	0.3	0.7	0.0	0.5	0.5	0.5	-0.6	-0.8	-0.6	0.7
Rb content in liver	20.7	25.7	29.7	-5.0	-5.3	-5.4	-5.1	5.1	5.2	5.2	-4.2
Se content in liver	0.0	0.0	0.2	0.0	0.1	-0.0	-0.0	0.0	0.0	0.0	0.4
Sr content in liver	0.2	0.2	0.6	0.0	-0.1	-0.3	0.8	0.0	-0.1	0.1	-0.8
Zn content in liver	0.5	0.6	2.2	-0.7	-0.9	-0.2	-0.1	0.7	-0.0	0.7	-1.5
Bone: minimum diameter	0.1	0.2	0.6	0.2	-0.2	0.2	0.8	0.2	-0.4	0.1	-0.7
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.1	0.0	-0.0	-0.4	0.0	0.2	0.1	0.1
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.0	-0.1	-0.1	0.6	0.1	-0.2	0.1	-0.1
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.6	0.4	0.6	-0.6	-0.4	0.2	-0.2	-0.2
Total locomotion distance, hab. session 1	1.8	2.6	4.3	1.9	1.6	2.1	1.0	-1.7	-1.5	-1.8	0.6
Locomotion velocity, hab. session 1	1.9	2.7	4.4	2.0	1.7	2.1	1.1	-1.8	-1.6	-1.8	0.9
Time in familiar zone, hab. session 2	0.4	0.4	1.6	-0.2	-0.0	-0.3	-1.3	-0.0	1.0	0.4	-0.2
Time in novel zone, hab. session 2	0.2	0.2	1.1	0.0	-0.3	-0.4	1.0	0.3	-0.3	-0.0	-0.5
Total zone transitions, hab. session 2	0.8	1.0	2.0	0.8	0.7	1.4	1.3	-0.8	-1.4	-0.6	0.4
Total locomotion distance, hab. session 2	3.4	4.5	5.9	2.2	1.9	2.4	2.4	-2.0	-2.4	-1.9	1.6
Locomotion velocity, hab. session 2	3.6	4.8	6.5	2.2	1.9	2.5	2.5	-2.0	-2.5	-1.9	1.8
Novel to familiar place preference ratio	3.5	3.6	5.4	1.9	2.0	1.8	2.3	-2.0	-1.8	-2.1	1.0
Novelty place preference	4.2	4.2	6.4	2.2	2.2	1.9	2.5	-2.1	-1.9	-2.2	1.1
Time in novel zone, NPP test	4.0	4.1	5.8	2.1	2.2	2.0	2.4	-2.1	-1.8	-2.2	1.2
Total zone transitions, NPP test	0.6	0.9	2.7	0.8	0.7	1.6	0.4	-0.6	-1.4	-0.4	0.7
Total locomotion distance, NPP test	1.8	2.4	4.2	1.5	1.3	2.0	1.4	-1.3	-2.1	-1.3	1.4
Locomotion velocity, NPP test	1.7	2.4	4.4	1.5	1.3	2.0	1.5	-1.2	-2.1	-1.3	1.3
Intraocular pressure	0.2	0.3	1.3	-0.4	-0.6	-0.2	0.2	0.3	-0.1	0.4	-1.1
Delta distance traveled before/after self-admin	0.1	0.1	0.5	0.0	0.3	0.2	0.7	-0.1	-0.4	-0.1	0.4
Delta ambulatory time before/after self-admin	0.4	0.4	0.9	0.3	0.6	0.6	0.9	-0.5	-0.7	-0.5	0.6
Parametrial fat weight	0.7	1.4	3.3	0.4	0.4	1.0	1.8	-0.7	-1.8	-0.7	1.5
Pavlov. Cond. lever latency	0.1	0.2	0.5	-0.3	-0.1	-0.5	-0.4	-0.1	0.7	-0.2	-0.6
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	0.7	0.7	0.8	0.4	-0.5	-1.0	-0.5	0.9
Pavlov. Cond. change in total contacts	0.2	0.2	1.2	0.4	0.3	0.2	0.2	-0.1	-0.5	-0.2	1.1
Pavlov. Cond. index score	0.6	0.7	1.9	0.7	0.6	0.9	1.0	-0.3	-1.4	-0.3	1.0
Pavlov. Cond. latency score	0.6	0.8	1.9	0.7	0.6	0.9	1.1	-0.4	-1.4	-0.4	1.0
Pavlov. Cond. lever contacts	0.2	0.3	0.8	0.3	0.2	0.4	0.7	0.1	-0.9	0.1	0.8
Pavlov. Cond. magazine entry number	0.5	0.6	2.1	-0.7	-0.7	-1.1	-0.6	0.4	1.4	0.4	-0.6
Pavlov. Cond. intertrial magazine entries	2.9	3.5	5.4	-1.8	-1.8	-2.0	-1.8	1.7	2.3	1.6	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.8	0.7	0.6	0.9	1.0	-0.4	-1.3	-0.3	1.1
Pavlov. Cond. response bias	0.4	0.5	1.3	0.5	0.5	0.8	0.6	-0.2	-1.1	-0.1	1.1
Pavlov. Cond. lever latency	6.7	9.1	10.7	-3.2	-3.3	-2.9	-3.0	2.9	2.7	3.1	-3.0
Pavlov. Cond. magazine entry latency	2.0	2.3	3.9	1.2	1.5	2.0	1.3	-1.3	-1.8	-1.4	1.5
Pavlov. Cond. change in total contacts	4.6	6.3	7.3	2.6	2.7	2.6	2.7	-2.4	-2.4	-2.5	2.2
Pavlov. Cond. index score	5.0	6.4	7.5	2.6	2.7	2.6	2.5	-2.4	-2.4	-2.6	2.5
Pavlov. Cond. latency score	4.4	5.5	6.8	2.4	2.6	2.5	2.1	-2.3	-2.1	-2.4	2.4
Pavlov. Cond. lever contacts	6.7	9.2	11.2	3.0	3.2	2.9	3.1	-2.8	-2.8	-3.0	3.3
Pavlov. Cond. magazine entry number	1.9	2.3	2.8	-1.4	-1.7	-1.6	-1.3	1.5	1.3	1.6	-1.7
Pavlov. Cond. intertrial magazine entries	1.3	1.6	3.1	-0.9	-1.2	-1.8	-1.1	1.1	1.7	1.2	-1.0
Pavlov. Cond. lever-magazine prob. diff.	5.6	7.2	8.4	2.7	2.9	2.8	2.6	-2.6	-2.5	-2.7	2.6
Pavlov. Cond. response bias	6.4	8.7	9.8	2.9	3.1	2.9	3.0	-2.8	-2.8	-3.0	3.1
Time in closed arm before self-admin	0.3	0.4	1.3	0.0	0.3	-0.7	-1.0	0.2	1.1	-0.0	0.4
Time in closed arm after self-admin	0.5	0.5	1.0	0.9	1.0	0.4	-0.5	-0.8	0.6	-0.8	0.7
Time in open arm before self-admin	0.3	0.3	0.7	-0.2	-0.5	-0.4	-0.6	0.7	0.5	0.6	-0.8
Time in open arm after self-admin	2.0	2.2	2.8	-1.4	-1.7	-1.7	-0.9	1.6	1.1	1.6	-1.5
Bone: periosteal estimation	0.1	0.1	0.6	0.3	-0.1	0.1	0.6	0.0	-0.2	-0.0	-0.8
Bone: periosteal perimeter	0.0	0.0	0.2	0.1	-0.2	0.0	0.3	-0.0	0.1	0.1	-0.4
Bone: post-yield work	0.1	0.1	0.2	0.2	-0.0	0.3	0.4	-0.0	-0.4	-0.0	-0.4
Progressive ratio test 1 active lever presses	0.3	0.3	1.2	0.3	0.2	1.1	-0.9	-0.2	-0.5	-0.2	0.2
Progressive ratio test 1 breakpoint	0.4	0.4	1.7	0.4	0.3	1.3	-0.7	-0.3	-0.7	-0.3	0.2
Progressive ratio test 1 inactive lever presses	0.6	0.6	1.0	1.0	0.8	0.9	-0.6	-0.8	-0.4	-0.8	0.7
Progressive ratio test 2 active lever presses	1.9	2.0	3.3	1.8	1.7	1.4	-0.2	-1.5	-0.4	-1.4	1.8
Progressive ratio test 2 breakpoint	1.3	1.5	2.6	1.6	1.4	1.1	-0.5	-1.4	-0.2	-1.2	1.6
Progressive ratio test 2 inactive lever presses	4.2	4.9	6.7	2.6	2.4	2.4	0.8	-2.6	-1.5	-2.4	2.3
Incentive Sensitization - Responses	1.6	1.6	3.1	1.7	1.5	0.9	0.6	-1.3	-0.6	-1.3	1.5
Incentive Sensitization - Breakpoint	1.7	1.7	3.2	1.8	1.6	0.9	0.6	-1.3	-0.6	-1.3	1.6
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.5	-0.6	-0.6	-0.4	-0.1	0.6	0.4	-0.7
Progressive ratio	3.2	3.6	5.0	2.2	2.2	1.9	1.7	-1.6	-1.9	-1.9	1.8
Food seeking constrained by brief footshock	3.7	4.6	6.0	2.3	2.4	1.7	2.2	-2.3	-1.4	-2.2	2.4
Seeking ratio, punishment vs. effort	0.6	0.8	1.3	-1.1	-1.1	-0.9	-0.6	0.5	1.0	0.9	-0.8
Retroperitoneal fat weight	0.6	1.9	4.9	0.4	0.6	1.3	2.0	-0.6	-2.2	-0.8	1.8
Reaction time number correct	0.9	1.2	3.0	1.7	1.3	0.9	0.7	-1.2	-0.4	-1.4	0.4
Reaction time mean minus median	0.3	0.4	1.2	1.0	0.6	0.4	-0.1	-0.5	0.4	-0.6	1.1
Reaction time mean minus median AUC	0.6	0.8	1.4	-0.7	-1.0	-0.8	-1.2	0.9	1.2	0.8	-0.4
Reaction time num false alarms	3.0	4.0	8.9	3.0	2.2	1.4	1.7	-2.0	-0.2	-2.1	2.3
Reaction time num false alarms AUC	3.2	4.5	10.5	3.2	2.3	1.7	1.8	-2.1	-0.5	-2.1	2.2
Reaction time trials correct on left	0.9	1.2	3.0	1.7	1.3	0.9	0.7	-1.2	-0.4	-1.4	0.4
Reaction time trials on left	0.7	1.0	2.7	1.6	1.2	0.8	0.6	-1.1	-0.3	-1.3	0.3
Reaction time mean	0.1	0.2	0.5	-0.1	-0.5	-0.5	-0.4	0.3	0.7	0.3	0.0
Reaction time mean AUC	0.1	0.1	0.3	-0.2	-0.4	-0.3	-0.4	0.3	0.5	0.2	0.2
Median of all reaction times	0.4	0.6	1.1	-0.7	-1.1	-0.8	-0.5	0.8	0.7	0.8	-0.6
Reaction time omissions	3.7	5.0	7.3	-1.8	-2.7	-2.4	-1.8	2.3	2.3	2.0	-2.3
Reaction time false alarm rate	2.0	2.8	5.5	2.4	1.8	1.3	1.4	-1.7	-0.5	-1.7	2.1
Reaction time premature initiation rate	0.5	0.6	1.8	1.0	0.9	-0.5	0.6	-0.7	0.5	-0.4	1.3
Reaction time premature initiations	0.7	0.9	2.1	1.5	1.2	-0.3	0.6	-0.9	0.7	-0.8	1.3
Std. dev. reaction times	0.2	0.3	1.5	0.2	-0.1	-0.4	-0.6	0.0	1.2	0.1	0.4
Reaction time trials completed	0.7	1.0	2.7	1.6	1.2	0.8	0.6	-1.1	-0.3	-1.3	0.3
Reaction time trials AUC	0.9	1.3	3.1	1.8	1.3	1.0	0.8	-1.2	-0.4	-1.4	0.4
Run reversals in cocaine runway, females	0.7	0.6	2.1	-0.8	-0.8	-0.0	1.5	0.2	-0.8	0.5	-0.8
Run reversals in cocaine runway, males	0.5	0.5	1.6	-0.3	-0.3	0.4	1.3	0.4	-1.2	0.3	-0.7
Latency to leave start box in cocaine runway	1.1	1.2	1.9	-0.8	-1.2	-0.9	-1.4	1.0	1.1	1.1	-1.2
Latency to leave start box in cocaine runway, F	1.7	1.9	3.0	-1.0	-1.3	-1.7	-1.4	1.3	1.7	1.3	-1.2
Latency to leave start box in cocaine runway, M	0.2	0.1	0.7	0.1	-0.2	0.8	-0.4	0.0	-0.5	0.1	-0.4
Std. dev. time between licks in bursts	0.9	1.1	1.5	1.2	1.2	1.1	0.9	-1.0	-0.9	-1.0	1.1
Total sessions with >9 infusions	0.3	0.3	1.8	0.3	0.2	0.4	-1.3	-0.3	0.5	-0.2	0.3
Short access day 1 total inactive lever presses	0.6	0.7	1.3	0.9	1.0	0.8	-0.0	-1.1	-0.3	-1.0	0.9
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.3	0.4	-0.2	-0.1	-0.0	0.2	-0.3	0.1
Short access day 1 total infusions	0.5	0.5	1.0	0.8	0.7	1.0	-0.5	-0.8	-0.6	-0.8	0.6
Short access day 10 total infusions	0.2	0.2	0.3	0.5	0.4	0.5	0.2	-0.5	-0.6	-0.4	0.6
Short access total infusions	0.6	0.7	1.4	0.8	0.7	1.2	0.1	-0.8	-1.0	-0.8	0.9
Short access day 1 locomotion	0.2	0.3	0.5	0.7	0.6	0.4	-0.4	-0.7	-0.0	-0.6	0.3
Short access day 10 total locomotion	0.0	0.1	0.3	0.1	0.2	-0.0	-0.5	0.1	0.2	-0.1	0.2
Short access total locomotion	0.4	0.4	0.7	0.8	0.8	0.4	-0.1	-0.6	-0.2	-0.7	0.8
One hour access (0.3 mA shock)	1.0	1.2	1.9	1.2	1.2	1.1	-0.6	-1.4	-0.0	-1.1	1.4
Compulsive drug intake	0.1	0.1	0.3	0.3	0.6	0.1	0.1	-0.2	0.3	-0.3	0.5
One hour access (shock baseline)	0.6	0.7	1.6	0.9	0.7	0.7	-0.7	-1.3	0.1	-0.8	0.9
Social response proportion	2.0	2.2	3.4	1.5	1.4	1.5	1.4	-1.8	-0.9	-1.6	1.6
Social responses	0.6	0.7	2.5	1.0	0.6	0.7	1.6	-0.7	-0.4	-0.6	0.5
Social time	0.2	0.2	0.6	-0.3	-0.6	0.1	-0.0	0.4	0.2	0.7	-0.8
Soleus weight	0.1	0.2	1.1	0.2	0.2	-0.3	0.1	-0.3	0.3	0.2	1.0
Bone: stiffness	0.4	0.6	1.1	0.7	0.7	0.8	1.0	-0.6	-1.0	-0.8	0.5
Tibialis anterior weight	0.2	0.7	1.9	0.6	0.7	1.4	-0.0	-0.6	-0.9	-0.4	1.3
Time to tail flick, vehicle, before self-admin	1.2	1.2	2.3	1.2	1.1	0.7	0.6	-1.4	-0.2	-1.2	1.5
Time to tail flick, vehicle, after self-admin	0.5	0.6	2.2	0.3	0.1	0.7	1.5	-0.4	-1.2	-0.4	0.0
Time to tail flick, test, before self-admin	0.5	0.5	2.3	0.1	0.5	-0.2	-1.3	-0.1	1.5	-0.2	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.1	-0.2	-0.5	-0.0	0.1	0.6	0.1	-0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.5	-0.5	0.1	0.8	0.5	-0.8	0.4	-0.7
Delta time to tail flick, test, before/after SA	0.6	0.5	1.3	-0.6	-1.1	-0.2	0.4	0.4	-0.6	0.6	-1.1
Tibia length	0.7	1.9	2.6	1.4	1.4	1.5	1.3	-1.4	-1.3	-1.6	0.8
Ambulatory time before self-admin	1.2	1.2	2.8	1.6	1.5	0.7	0.3	-0.8	-0.1	-1.2	1.7
Ambulatory time after self-admin	1.9	2.1	4.0	1.3	1.7	1.1	1.5	-1.2	-1.2	-1.4	2.0
Bone: tissue strength	1.4	1.4	2.8	1.1	0.9	1.3	1.3	-0.8	-1.7	-0.8	1.3
Total heroin consumption	0.6	0.7	1.4	-0.9	-0.9	-1.2	0.8	0.7	0.3	0.8	-0.8
Bone: trabecular number	0.1	0.1	0.5	-0.0	-0.1	0.3	0.0	-0.2	-0.1	-0.2	-0.7
Bone: trabecular spacing	0.1	0.1	0.3	-0.2	-0.1	-0.5	0.4	0.3	0.1	0.3	0.3
Bone: trabecular thickness	0.4	0.5	1.1	0.9	0.5	0.8	0.0	-0.8	-0.1	-1.1	-0.4
Bone: trabecular tissue density	2.2	3.1	4.0	1.8	1.8	1.9	1.2	-1.7	-1.8	-1.7	2.0
Water consumed over 24 hours	1.3	1.6	3.3	1.8	1.4	0.9	0.8	-1.5	-0.6	-1.5	1.0
Number of responses in last shaping day	0.3	0.3	0.6	0.6	0.6	0.7	-0.5	-0.8	0.0	-0.7	-0.2