Hub : Genes

Atp6v0d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Atp6v0d1 0.02 0.02 9.9e-04 0.01 0.01 0.01 0.01 5.0e-03 4.2e-03 6.0e-03 2.5e-03
2 Brain intron excision ratio chr19_50328051_50357042 0.18 0.16 4.5e-06 0.07 0.06 0.07 0.06 4.2e-07 6.7e-06 1.7e-07 2.5e-06
3 IC gene expression Atp6v0d1 0.1 0.08 2.3e-03 0.04 0.02 0.04 0.02 5.7e-03 4.4e-02 1.0e-02 3.8e-02
4 Brain intron excision ratio chr19_50342955_50357042 0.64 0.08 2.6e-05 0.04 0.06 0.07 0.03 7.1e-05 4.9e-06 7.4e-07 4.2e-04
5 Brain gene expression Atp6v0d1 0.08 0.06 6.5e-07 0.07 0.06 0.07 0.07 9.3e-07 1.6e-06 3.1e-07 3.0e-07
6 PL gene expression Atp6v0d1 0.09 0.08 1.1e-03 0.02 0.02 0.02 0.02 1.3e-03 2.2e-03 1.4e-03 1.6e-03
7 pVTA gene expression Atp6v0d1 0.16 0.11 4.0e-09 0.11 0.11 0.1 0.12 3.0e-09 3.0e-09 1.5e-08 1.5e-09
8 IC intron excision ratio chr19_50328051_50357042 0.06 0.04 6.4e-03 0.01 0.03 0.05 0.01 1.1e-01 2.4e-02 3.0e-03 1.3e-01
9 PL intron excision ratio chr19_50328051_50357042 0.06 0.06 1.7e-04 0.02 0.02 0.02 0.01 4.8e-03 1.3e-03 6.7e-03 8.8e-03
10 NAcc intron excision ratio chr19_50328051_50357042 0.03 0.04 9.9e-03 0.01 0.01 0.01 0.01 4.0e-02 8.6e-03 2.8e-02 2.5e-02
11 IL gene expression Atp6v0d1 0.17 0.12 2.7e-03 0.09 0.06 0.02 0.06 3.2e-03 1.5e-02 1.0e-01 1.3e-02
12 BLA mRNA stability Atp6v0d1 0.07 0.06 4.5e-04 0.02 0.06 0.03 0.03 2.5e-02 6.7e-04 1.2e-02 1.6e-02
13 pVTA intron excision ratio chr19_50342955_50357042 0.04 0.03 2.9e-04 0.01 0.04 0.02 0.02 2.1e-02 4.7e-04 6.5e-03 6.5e-03
14 pVTA mRNA stability Atp6v0d1 0.03 0.02 4.0e-03 0.01 0.02 0.01 0.01 3.8e-02 1.7e-02 7.5e-02 5.3e-02
15 Liver gene expression Atp6v0d1 0.03 0.03 8.4e-05 0.02 0.03 0.01 0.03 1.6e-03 5.4e-04 2.0e-02 5.7e-04
16 IC intron excision ratio chr19_50342955_50357042 0.07 0.05 1.8e-03 0.03 0.06 0.04 0.05 1.6e-02 2.1e-03 1.2e-02 5.1e-03
17 PL mRNA stability Atp6v0d1 0.05 0.03 7.4e-07 0.05 0.06 0.04 0.04 2.4e-06 1.1e-06 7.4e-05 1.6e-05
18 Brain mRNA stability Atp6v0d1 0.04 0.04 1.1e-03 0.02 0.03 0.01 0.02 7.0e-03 1.7e-03 4.5e-02 7.2e-03
19 OFC intron excision ratio chr19_50328051_50342690 0.15 0.13 8.4e-03 0.04 0.05 0.01 0.04 4.1e-02 2.8e-02 1.7e-01 4.8e-02
20 PL intron excision ratio chr19_50342955_50357042 0.03 0.03 1.4e-04 0.02 0.02 0.01 0.01 6.7e-03 1.6e-03 5.2e-02 1.7e-02
21 RMTg mRNA stability Atp6v0d1 0.16 0.12 4.6e-04 0.16 0.14 0.16 0.17 3.9e-05 1.6e-04 4.0e-05 3.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.10.10.60.30.80.3-0.80.40.30.3-0.00.40.40.20.3-0.30.30.3-0.30.30.3-0.3-0.20.2
Area under the delay curve0.10.11.2-0.2-1.1-0.00.9-0.7-0.1-0.10.10.10.10.10.0-0.1-0.00.00.00.1-0.1-0.0-0.10.7
BMI with tail0.10.41.40.81.00.6-1.20.50.50.60.70.50.60.80.5-0.40.40.4-0.40.40.3-0.4-0.40.8
BMI without tail0.00.00.20.1-0.20.1-0.1-0.1-0.2-0.00.30.00.00.30.0-0.1-0.00.1-0.00.1-0.0-0.1-0.20.4
Body weight0.41.74.91.51.91.0-2.21.51.21.01.31.11.01.31.2-1.11.21.2-1.21.21.2-1.2-1.10.8
Weight adjusted by age0.00.00.6-0.4-0.30.1-0.2-0.20.1-0.1-0.8-0.1-0.10.0-0.0-0.00.10.0-0.10.00.1-0.1-0.0-0.1
Bone surface1.22.23.81.51.91.2-1.81.51.61.31.31.51.51.11.5-1.51.61.5-1.61.51.5-1.5-1.40.9
Bone volume1.01.83.51.41.91.1-1.81.41.41.20.91.31.30.91.3-1.31.41.3-1.41.31.4-1.3-1.20.6
Breakpoint value in progressive ratio session1.92.34.1-1.6-0.8-1.50.8-1.5-1.3-1.4-2.0-1.6-1.5-1.5-1.61.6-1.5-1.61.6-1.7-1.51.61.7-1.7
Number of licking bursts0.50.92.20.90.71.5-0.60.81.01.10.81.00.90.91.0-1.00.91.0-1.01.00.9-0.9-0.90.7
Context. condit. distance diff. score0.10.20.8-0.5-0.3-0.60.3-0.40.0-0.6-0.3-0.3-0.5-0.7-0.30.3-0.2-0.30.2-0.3-0.20.30.4-0.9
Locomotion velocity, session 10.10.10.80.4-0.10.10.50.20.10.30.40.40.40.30.3-0.30.20.3-0.20.40.2-0.3-0.40.9
Locomotion distance, session 10.10.10.3-0.4-0.5-0.40.4-0.3-0.4-0.4-0.3-0.4-0.5-0.5-0.30.3-0.3-0.30.3-0.3-0.30.30.3-0.2
Locomotion velocity, session 20.81.01.7-1.1-0.6-1.10.3-1.0-0.9-1.1-0.9-1.2-1.3-1.3-1.01.0-0.9-0.90.9-0.9-0.90.90.9-1.3
Locomotion distance, session 20.20.20.5-0.4-0.5-0.70.4-0.4-0.3-0.6-0.4-0.6-0.7-0.6-0.40.4-0.4-0.40.4-0.4-0.40.30.4-0.5
Locomotion velocity, session 30.30.31.1-0.7-1.0-0.31.1-0.7-0.6-0.3-0.6-0.4-0.3-0.3-0.50.5-0.6-0.50.6-0.5-0.60.50.50.0
Locomotion distance, session 30.10.10.7-0.5-0.8-0.10.7-0.3-0.2-0.3-0.2-0.3-0.4-0.4-0.30.3-0.2-0.20.2-0.2-0.20.20.3-0.6
Stereotopy head waving bouts, day 30.10.20.70.40.20.8-0.10.40.30.60.50.40.40.50.3-0.40.30.4-0.30.40.3-0.4-0.40.5
Stereotopy head waving duration, day 30.60.71.50.91.21.1-1.10.90.81.00.80.80.80.80.8-0.80.80.8-0.80.80.8-0.8-0.80.7
Locomotion velocity, session 70.10.10.2-0.20.2-0.5-0.1-0.30.1-0.3-0.4-0.1-0.1-0.5-0.10.2-0.1-0.20.1-0.2-0.00.20.2-0.5
Locomotion distance, session 70.10.10.5-0.5-0.6-0.20.7-0.4-0.2-0.3-0.3-0.3-0.3-0.5-0.30.3-0.2-0.30.2-0.3-0.20.30.3-0.7
Stereotopy head waving bouts, day 70.20.20.60.40.50.6-0.20.50.60.80.40.60.70.60.5-0.40.40.4-0.40.40.4-0.4-0.40.5
Stereotopy head waving duration, day 70.70.81.60.90.81.1-0.30.90.91.30.81.11.21.10.9-0.90.80.8-0.80.80.7-0.7-0.81.1
Locomotion velocity, session 80.00.10.4-0.10.3-0.5-0.2-0.2-0.0-0.1-0.60.00.1-0.1-0.00.1-0.2-0.10.2-0.2-0.20.20.20.1
Locomotion distance, session 80.50.81.6-0.9-0.9-1.30.9-1.0-0.5-1.1-0.7-0.8-1.0-1.1-0.80.8-0.8-0.80.7-0.8-0.80.80.8-1.0
Degree of sensitization distance0.00.00.10.10.10.20.00.00.20.10.20.10.20.10.1-0.10.10.1-0.10.10.1-0.1-0.1-0.0
Degree of sensitization stereotypy0.40.40.80.60.60.6-0.40.70.70.90.60.80.80.80.6-0.60.50.6-0.50.60.5-0.5-0.50.7
Conditioned locomotion1.71.93.21.61.51.3-1.11.51.81.31.31.31.21.11.5-1.41.51.5-1.61.41.6-1.5-1.40.3
Cocaine response after cond. corrected0.70.83.01.10.70.7-0.60.80.70.70.91.11.21.30.8-0.80.70.7-0.60.80.6-0.7-0.91.7
Cocaine response after cond. not corrected0.20.32.30.50.10.2-0.10.30.10.30.50.60.70.90.3-0.30.10.2-0.10.30.1-0.2-0.41.5
Cocaine response before conditioning1.21.42.1-1.4-1.4-1.01.3-1.3-1.4-1.0-0.8-1.2-1.2-1.1-1.21.2-1.2-1.21.2-1.1-1.31.21.1-0.7
Saline control response4.25.67.62.82.22.0-1.92.32.52.12.52.32.22.42.5-2.52.52.5-2.52.52.4-2.5-2.52.1
Bone: connectivity density0.00.10.1-0.30.3-0.1-0.3-0.2-0.2-0.1-0.4-0.1-0.1-0.3-0.20.2-0.2-0.20.2-0.3-0.20.30.3-0.3
Bone: cortical apparent density0.81.13.5-1.2-1.7-0.11.9-1.0-1.1-0.4-1.1-0.8-0.6-0.6-1.01.0-1.1-1.11.1-1.1-1.11.11.1-0.4
Bone: cortical area0.30.41.10.70.90.3-1.00.70.80.50.40.60.60.40.6-0.60.70.6-0.70.60.8-0.7-0.60.3
Bone: cortical porosity0.60.62.9-0.5-0.6-1.70.8-0.5-0.4-1.2-0.7-0.7-0.8-1.0-0.60.6-0.5-0.50.5-0.6-0.40.50.6-1.2
Bone: cortical porosity0.50.52.6-0.5-0.8-1.61.0-0.5-0.3-1.1-0.7-0.6-0.7-1.0-0.50.5-0.4-0.50.4-0.5-0.40.40.5-1.0
Bone: cortical thickness0.10.21.00.50.90.2-1.00.40.50.40.00.40.50.30.4-0.40.40.4-0.40.30.5-0.3-0.30.3
Bone: cortical thickness0.20.21.80.00.6-0.4-0.90.20.2-0.4-0.2-0.4-0.5-0.6-0.20.10.1-0.1-0.1-0.20.20.00.2-1.4
Bone: cortical tissue density0.91.23.8-1.2-1.8-0.12.0-1.1-1.2-0.4-1.2-0.8-0.6-0.6-1.01.0-1.1-1.11.1-1.1-1.11.11.1-0.4
Condit. Reinf. active minus inactive responses4.44.97.7-2.3-2.6-2.12.8-2.3-2.2-2.2-2.3-2.0-2.0-2.2-2.22.1-2.2-2.22.2-2.2-2.12.12.1-1.8
Condit. Reinf. active-inactive response ratio3.94.26.5-2.0-2.4-2.32.5-2.2-2.1-2.1-1.9-1.8-1.7-1.9-2.02.0-2.0-2.02.0-2.0-2.02.02.0-1.6
Condit. Reinf. active responses3.34.16.3-2.2-2.5-1.92.5-2.0-2.0-2.0-2.0-1.9-1.9-2.2-2.01.9-1.9-2.01.9-1.9-1.91.91.9-1.9
Condit. Reinf. inactive responses0.20.30.6-0.6-0.6-0.00.5-0.3-0.5-0.3-0.5-0.6-0.6-0.7-0.50.5-0.5-0.50.5-0.5-0.40.50.5-0.8
Incentive salience index mean2.53.05.2-1.8-2.0-1.82.3-1.8-1.6-1.8-1.8-1.6-1.6-1.9-1.61.6-1.6-1.71.6-1.6-1.61.61.6-1.6
Condit. Reinf. lever presses0.20.30.8-0.5-0.4-0.90.9-0.6-0.4-0.8-0.7-0.4-0.4-0.8-0.40.4-0.4-0.40.4-0.4-0.40.40.4-0.6
Condit. Reinf. active minus inactive responses0.70.91.11.10.41.0-0.81.00.81.00.81.00.91.01.0-1.01.01.0-1.01.01.0-1.0-1.00.8
Condit. Reinf. active-inactive response ratio0.70.81.60.80.71.3-1.01.10.61.10.80.90.90.90.8-0.80.80.8-0.80.80.9-0.8-0.80.7
Condit. Reinf. active responses0.30.40.70.80.30.4-0.80.70.70.50.60.60.50.60.7-0.70.70.7-0.80.70.8-0.7-0.70.4
Condit. Reinf. inactive responses0.30.31.2-0.4-0.6-1.10.2-0.7-0.3-0.9-0.5-0.6-0.7-0.6-0.50.5-0.4-0.40.4-0.5-0.40.40.5-0.7
Condit. Reinf. lever presses2.73.86.0-2.1-1.0-2.10.3-1.8-1.8-2.1-2.1-2.1-2.2-2.2-1.92.0-1.8-1.91.8-2.0-1.81.92.0-2.4
Condit. Reinf. lever reinforcers received0.00.10.40.30.1-0.0-0.70.20.2-0.00.00.1-0.00.10.2-0.20.20.2-0.30.20.3-0.2-0.2-0.2
Conditioned reinforcement - actives0.61.12.2-0.9-1.4-1.51.3-1.0-1.2-1.3-0.5-1.1-1.1-0.9-1.11.0-1.0-1.01.0-0.9-1.00.90.8-0.3
Conditioned reinforcement - inactives0.20.20.80.70.30.50.20.50.30.70.40.70.90.70.4-0.40.20.2-0.20.30.2-0.2-0.20.8
Conditioned locomotion0.81.01.51.10.80.9-0.80.91.01.01.21.21.21.11.0-1.00.90.9-0.90.90.9-0.9-0.91.2
Patch foraging indifference point 0 sec2.85.16.22.42.02.2-2.02.32.52.22.52.22.12.22.3-2.32.42.4-2.42.42.3-2.4-2.31.7
Patch foraging indifference point AUC1.72.54.61.61.91.9-2.11.71.71.51.81.41.21.21.6-1.51.61.6-1.71.51.6-1.6-1.50.4
Delay disc. indifference point, 0s delay0.60.61.3-0.8-0.9-0.80.8-1.2-1.0-0.8-0.6-0.7-0.6-0.5-0.70.7-0.8-0.80.8-0.7-0.90.80.70.2
Delay disc. indifference point, 16s delay0.10.10.50.2-0.60.20.40.10.1-0.00.50.30.20.10.3-0.40.40.4-0.40.50.4-0.5-0.50.7
Delay disc. indifference point, 2s delay0.20.20.70.40.00.60.1-0.00.50.40.40.80.80.50.6-0.50.40.4-0.40.40.3-0.3-0.40.7
Delay disc. indifference point, 24s delay0.00.00.2-0.0-0.30.20.50.00.0-0.10.3-0.0-0.1-0.30.0-0.00.00.0-0.10.10.0-0.1-0.1-0.2
Delay disc. indifference point, 4s delay0.30.31.1-0.6-0.9-0.30.6-1.1-0.6-0.3-0.4-0.3-0.20.0-0.50.5-0.5-0.50.5-0.5-0.50.60.50.3
Delay disc. indifference point, 8s delay0.20.32.4-0.4-1.50.01.4-0.8-0.10.1-0.30.10.10.20.0-0.1-0.00.00.00.1-0.0-0.1-0.10.6
Indifference point function ln k0.30.52.1-0.4-1.3-0.91.5-0.6-0.6-0.6-0.3-0.3-0.3-0.1-0.60.5-0.7-0.70.7-0.5-0.70.60.50.4
Indifference point function log k0.30.52.1-0.4-1.3-0.91.5-0.6-0.6-0.6-0.3-0.3-0.3-0.1-0.60.5-0.7-0.70.7-0.5-0.70.60.50.4
Patch foraging total patch changes 0 sec2.75.06.22.42.02.1-2.12.32.52.22.42.22.02.22.3-2.32.32.4-2.42.32.3-2.4-2.31.6
Patch foraging total patch changes 12 sec2.63.44.71.81.82.2-1.62.02.02.01.91.71.61.51.9-1.92.02.0-2.01.91.9-1.9-1.90.8
Patch foraging total patch changes 18 sec2.33.55.12.02.01.8-2.32.12.21.72.01.71.41.51.8-1.92.02.0-2.01.92.1-2.0-1.80.5
Patch foraging total patch changes 24 sec0.20.31.00.20.81.0-0.90.50.60.80.00.40.30.20.6-0.50.60.6-0.60.50.5-0.5-0.4-0.5
Patch foraging total patch changes 6 sec1.93.03.71.81.71.8-1.91.51.81.71.71.71.61.71.8-1.71.81.8-1.81.71.7-1.7-1.71.1
Patch foraging time to switch 0 sec0.81.72.4-1.4-1.1-1.51.4-1.5-1.5-1.3-1.5-1.2-1.1-1.3-1.21.3-1.3-1.31.3-1.2-1.31.31.2-0.9
Patch foraging water rate 0 sec1.53.25.11.92.12.0-2.32.21.91.72.01.61.51.61.7-1.71.71.7-1.71.71.7-1.8-1.71.2
Patch foraging water rate 12 sec0.20.32.20.50.70.7-1.50.60.40.50.60.50.40.60.4-0.40.50.4-0.40.40.4-0.4-0.40.5
Patch foraging water rate 18 sec0.10.10.4-0.10.00.7-0.60.30.30.40.30.20.10.20.2-0.20.20.2-0.20.10.2-0.1-0.1-0.3
Patch foraging water rate 24 sec0.00.00.10.1-0.10.2-0.30.20.10.10.20.0-0.10.10.0-0.10.10.1-0.10.10.2-0.2-0.2-0.2
Patch foraging water rate 6 sec0.71.12.61.01.21.4-1.61.31.11.10.91.00.90.90.9-0.91.00.9-1.00.91.1-0.9-0.80.1
Seeking ratio, delayed vs. immediate footshock2.43.03.91.71.01.7-0.51.71.91.71.72.02.01.61.9-1.91.81.8-1.81.91.8-1.8-1.91.5
Distance traveled before self-admin0.50.72.20.41.01.5-0.70.41.31.30.31.01.10.40.8-0.60.80.6-0.70.50.8-0.5-0.3-0.8
Distance traveled after self-admin0.10.10.7-0.1-0.20.70.8-0.00.30.7-0.00.40.40.10.3-0.30.30.3-0.30.20.3-0.2-0.2-0.4
Extensor digitorum longus weight0.93.46.5-1.9-1.0-1.80.9-1.6-1.8-2.0-1.9-2.1-2.2-2.3-1.91.9-1.7-1.81.7-1.9-1.61.81.9-2.6
Bone: elastic displacement2.02.33.11.61.21.7-1.41.51.41.81.61.51.61.81.4-1.51.41.4-1.41.51.4-1.5-1.51.7
Bone: elastic work0.81.01.80.91.11.2-1.41.00.91.21.00.91.01.10.9-0.90.90.9-0.90.91.0-0.9-0.91.0
Bone: endosteal estimation0.10.10.30.3-0.30.30.60.40.20.30.60.20.20.00.3-0.30.40.3-0.40.30.4-0.4-0.40.1
Bone: endosteal perimeter0.10.20.50.40.30.2-0.40.60.70.10.60.40.2-0.00.5-0.50.60.5-0.60.50.6-0.6-0.5-0.0
Epididymis fat weight1.96.48.72.52.42.2-3.02.62.72.33.02.52.32.32.5-2.62.72.6-2.72.62.7-2.6-2.51.6
Delta time in closed arm before/after self-admin0.20.10.30.3-0.30.20.50.00.20.20.50.40.30.30.4-0.40.40.4-0.40.50.4-0.5-0.50.4
Delta time in open arm before/after self-admin0.10.10.2-0.1-0.10.20.2-0.30.10.3-0.40.20.30.4-0.10.2-0.2-0.30.3-0.3-0.30.40.40.2
Diff in mean of infusions in LGA sessions0.60.71.6-0.80.1-0.8-0.2-0.9-0.5-0.9-1.3-0.8-0.8-1.0-0.80.8-0.8-0.80.8-0.9-0.80.91.0-1.2
Delay discount exponential model param0.10.21.20.21.10.1-1.00.70.20.20.0-0.0-0.0-0.00.1-0.00.10.1-0.10.00.2-0.1-0.0-0.6
Extinction: sum of active levers before priming0.60.61.1-0.50.0-1.1-0.6-0.3-0.9-0.9-0.6-1.0-1.0-0.6-0.90.9-0.9-0.90.9-0.9-0.90.90.9-0.4
Active lever presses in extinction session 60.00.00.30.1-0.4-0.20.5-0.0-0.0-0.10.0-0.0-0.0-0.00.0-0.10.10.1-0.10.10.1-0.2-0.2-0.0
Bone: final force1.11.72.8-1.4-1.0-1.60.8-1.3-1.0-1.5-1.5-1.4-1.4-1.7-1.31.3-1.2-1.21.2-1.3-1.11.21.3-1.6
Bone: final moment0.50.71.2-0.9-0.7-1.10.7-0.9-0.6-1.0-1.0-0.9-0.9-1.1-0.90.8-0.8-0.80.8-0.8-0.70.80.8-0.9
Food consumed during 24 hour testing period0.10.20.60.3-0.20.1-0.30.50.50.10.80.2-0.10.10.4-0.40.50.5-0.60.50.6-0.6-0.5-0.4
Glucose1.42.23.3-1.6-1.7-1.11.5-1.6-1.8-1.0-1.5-1.4-1.2-1.0-1.51.5-1.6-1.61.7-1.5-1.71.61.5-0.7
Heart weight0.00.00.30.2-0.1-0.20.10.1-0.10.10.00.10.20.3-0.00.1-0.1-0.10.1-0.1-0.20.10.10.5
Delay discount hyperbolic model param0.20.21.50.41.20.1-1.10.90.30.30.20.00.00.00.2-0.20.20.2-0.20.10.3-0.2-0.1-0.6
Intermittent access intake day 1-15 change1.12.33.3-1.6-1.8-1.51.4-1.5-1.8-1.4-1.2-1.7-1.7-1.4-1.61.6-1.6-1.51.5-1.5-1.51.51.4-1.1
Intermittent access intake escalation1.32.63.8-1.7-1.9-1.61.6-1.6-1.9-1.5-1.3-1.7-1.7-1.5-1.71.6-1.7-1.61.6-1.5-1.61.61.5-1.1
Intermittent access intake escalation 20.91.12.0-0.9-1.4-1.11.2-0.9-1.3-0.9-0.7-1.1-1.1-0.8-1.11.0-1.1-1.01.0-1.0-1.11.00.9-0.6
Intermitt. access day 1 inactive lever presses0.00.11.10.1-0.8-0.31.0-0.1-0.3-0.20.2-0.00.00.2-0.00.0-0.2-0.10.10.0-0.20.1-0.10.9
Intermitt. access day 15 inactive lever presses0.10.10.2-0.4-0.3-0.20.3-0.3-0.3-0.2-0.3-0.10.0-0.5-0.30.3-0.4-0.40.4-0.4-0.40.50.4-0.2
Intermitt. access escalation Index0.30.40.70.30.50.8-0.70.40.40.80.60.60.70.50.6-0.70.60.7-0.60.70.6-0.7-0.70.7
Intermittent access day 1 total infusions0.10.21.70.2-0.6-0.60.9-0.2-0.5-0.40.50.10.20.20.0-0.1-0.10.00.10.2-0.2-0.1-0.31.3
Intermittent access day 15 total infusions1.52.24.6-1.4-2.2-1.91.9-1.6-2.0-1.6-0.7-1.4-1.4-1.0-1.51.4-1.5-1.41.5-1.2-1.61.31.10.1
Intermittent access terminal intake (last 3 days)2.53.35.6-1.7-2.3-2.32.2-1.8-2.4-2.0-1.0-1.8-1.8-1.5-1.91.7-1.9-1.81.9-1.6-1.91.71.5-0.5
Intermittent access total infusions2.02.34.7-1.4-2.0-2.21.8-1.6-2.0-1.9-0.7-1.5-1.5-1.3-1.51.4-1.5-1.41.5-1.3-1.61.31.2-0.3
Intermittent access day 1 locomotion1.62.17.01.40.41.1-0.11.11.11.21.81.61.61.61.4-1.51.31.4-1.31.51.2-1.5-1.62.6
Intermittent access day 15 total locomotion0.40.84.10.90.00.7-0.00.60.40.91.21.01.01.20.8-0.80.60.7-0.60.80.5-0.7-0.92.0
Intermittent access total locomotion0.30.43.40.6-0.30.10.60.20.10.30.80.70.80.80.4-0.50.30.3-0.20.50.2-0.4-0.61.8
Intermittent access standard deviation0.20.40.90.90.60.4-0.30.70.50.60.80.60.70.80.6-0.50.50.5-0.50.50.5-0.5-0.60.7
Left kidney weight1.77.914.3-3.1-1.7-2.51.0-2.5-2.5-2.8-3.0-3.0-3.1-3.1-2.82.9-2.7-2.82.7-3.0-2.72.93.1-3.8
Right kidney weight1.88.215.9-3.1-1.4-2.70.5-2.5-2.6-2.9-3.1-3.1-3.2-3.2-2.93.0-2.7-2.92.7-3.0-2.73.03.2-4.0
Cocaine induced anxiety3.14.56.62.42.62.1-2.52.31.92.12.02.12.22.22.0-2.01.91.9-1.92.01.9-1.9-1.92.4
Post-drug Anxiety0.90.92.21.01.01.0-1.21.00.81.00.91.01.01.20.9-0.80.80.8-0.70.80.7-0.8-0.81.5
Baseline Anxiety1.82.15.6-1.6-2.4-1.32.0-1.6-1.4-1.4-1.0-1.4-1.5-1.2-1.41.3-1.4-1.31.3-1.3-1.41.31.2-0.9
Tail length0.00.10.3-0.1-0.3-0.60.20.0-0.2-0.50.1-0.2-0.3-0.3-0.0-0.10.10.1-0.10.10.1-0.2-0.2-0.3
Length with tail0.10.52.00.71.20.0-1.40.90.70.10.60.40.20.40.6-0.60.80.7-0.80.60.8-0.7-0.6-0.2
Length without tail0.51.75.01.51.90.8-2.21.51.41.01.41.11.01.31.2-1.21.31.2-1.31.21.3-1.2-1.10.7
Times rat made contact with spout1.21.31.81.00.51.1-0.41.21.31.21.01.11.01.01.3-1.31.31.3-1.41.31.3-1.4-1.30.8
Lifetime Intake1.62.04.1-1.4-1.8-2.01.6-1.5-1.9-1.8-0.7-1.4-1.4-1.2-1.41.3-1.4-1.31.4-1.2-1.41.21.0-0.3
Liver weight, left0.20.41.50.41.20.6-1.00.60.60.70.30.50.60.50.6-0.60.60.6-0.60.50.6-0.5-0.50.1
Liver weight, right0.40.82.71.01.40.3-1.61.00.90.40.90.60.50.70.8-0.80.90.9-0.90.80.9-0.9-0.80.5
Locomotor activity2.64.16.42.22.51.9-2.51.92.41.81.92.01.91.82.0-2.02.12.0-2.11.92.1-2.0-1.91.3
Locomotor testing distance2.13.85.02.22.11.7-2.21.92.21.71.81.91.91.82.0-2.02.02.0-2.01.92.0-2.0-1.91.6
Locomotor testing rearing0.30.62.80.91.50.6-1.70.91.00.50.50.60.60.60.6-0.60.70.6-0.60.50.7-0.6-0.50.0
Locomotion in novel chamber2.43.13.81.91.31.7-1.41.71.71.71.91.91.91.71.8-1.81.71.7-1.71.81.7-1.7-1.81.8
Locomotion in novel chamber post-restriction1.82.94.01.71.21.7-1.41.61.61.71.91.61.51.71.7-1.71.71.7-1.71.81.8-1.8-1.92.0
Fecal boli incidents, locomotor time 10.91.23.30.91.31.1-1.81.20.81.31.00.60.50.91.0-1.11.21.2-1.21.21.3-1.3-1.20.4
Change in fecal boli incidents, locomotor task0.40.40.8-0.6-0.7-0.60.7-0.8-0.6-0.5-0.3-0.6-0.6-0.3-0.70.7-0.8-0.70.8-0.7-0.90.80.8-0.1
Time >=10cm from walls, locomotor time 10.40.40.80.4-0.10.50.00.20.50.70.60.40.40.90.6-0.70.70.8-0.70.80.7-0.8-0.80.8
Bouts of movement, locomotor time 10.20.20.70.50.70.3-0.50.60.00.50.40.30.40.50.3-0.30.30.3-0.30.40.2-0.3-0.40.8
Total resting periods, locomotor time 10.00.00.30.20.30.10.00.3-0.30.30.20.00.10.30.0-0.0-0.00.00.00.1-0.1-0.0-0.10.5
Rest time, locomotor task time 10.10.10.5-0.00.4-0.40.1-0.2-0.6-0.1-0.1-0.20.00.1-0.20.2-0.4-0.20.4-0.2-0.40.30.10.7
Distance moved, locomotor task time 10.10.10.30.3-0.20.6-0.10.30.50.30.30.40.30.40.3-0.40.40.3-0.40.30.4-0.4-0.30.1
Vertical activity count, locomotor time 10.41.01.81.00.41.3-1.01.21.10.81.30.80.60.60.9-1.01.11.0-1.11.01.2-1.1-1.00.3
Time >=10cm from walls, locomotor time 20.20.40.8-0.7-0.4-0.70.3-0.8-0.5-0.5-0.9-0.7-0.7-0.2-0.70.6-0.6-0.60.6-0.6-0.60.60.6-0.3
Bouts of movement, locomotor time 20.50.91.1-0.9-0.8-0.91.0-0.8-1.0-1.1-0.8-0.9-0.9-1.0-0.90.9-1.0-0.91.0-0.9-1.00.90.9-0.8
Total resting periods, locomotor time 20.61.11.4-1.0-0.8-1.01.0-0.9-1.2-1.1-0.9-1.1-1.0-1.2-1.11.1-1.1-1.11.1-1.1-1.11.11.1-1.0
Rest time, locomotor task time 20.40.61.3-0.8-0.6-0.80.6-0.6-1.1-0.6-0.5-1.0-0.9-0.7-0.80.8-0.8-0.70.8-0.7-0.80.70.6-0.4
Distance moved, locomotor task time 20.70.81.61.00.91.0-0.90.71.30.90.61.11.11.20.9-0.80.80.7-0.80.70.9-0.7-0.60.8
Vertical activity count, locomotor time 21.01.42.31.31.11.5-1.31.31.51.01.21.21.11.11.1-1.11.21.1-1.21.11.2-1.1-1.10.9
Light reinforcement 12.15.18.32.42.62.0-2.72.42.92.02.22.22.11.72.3-2.32.42.3-2.42.22.4-2.3-2.10.8
Light reinforcement 22.13.35.01.71.42.2-1.31.62.12.01.81.91.81.51.9-1.91.91.9-1.91.91.9-1.9-1.91.1
Bone: marrow area0.00.10.50.2-0.40.30.70.40.20.30.50.20.10.00.2-0.30.30.3-0.30.30.3-0.3-0.30.1
Bone: maximum diameter0.40.71.00.90.60.6-0.80.91.00.60.90.80.70.60.8-0.90.90.9-0.90.90.9-0.9-0.90.6
Bone: maximum force0.30.50.9-0.8-0.4-0.90.3-0.7-0.5-0.8-0.9-0.7-0.7-0.9-0.70.7-0.6-0.70.7-0.7-0.60.70.7-0.9
Bone: maximum moment0.00.10.2-0.3-0.2-0.40.2-0.3-0.1-0.3-0.4-0.2-0.2-0.4-0.20.2-0.2-0.20.2-0.3-0.20.30.3-0.2
Mean time between licks in bursts0.00.10.9-0.1-1.00.50.60.10.00.30.00.20.1-0.00.1-0.10.10.0-0.10.10.1-0.1-0.1-0.1
Mean num. licks in bursts0.00.00.4-0.2-0.3-0.60.30.1-0.1-0.20.0-0.2-0.2-0.3-0.10.00.0-0.0-0.0-0.00.1-0.0-0.0-0.3
Cd content in liver0.10.10.20.00.3-0.3-0.4-0.2-0.2-0.3-0.0-0.2-0.1-0.1-0.20.3-0.3-0.30.3-0.3-0.30.30.3-0.3
Co content in liver0.00.00.1-0.00.0-0.3-0.3-0.1-0.2-0.20.0-0.3-0.3-0.1-0.30.2-0.2-0.20.2-0.2-0.10.20.2-0.2
Cu content in liver0.81.01.7-0.9-0.5-1.30.3-1.1-1.0-1.2-0.6-1.1-1.2-1.1-1.11.0-1.0-1.01.0-1.0-1.01.01.0-0.9
Fe content in liver2.32.85.11.72.21.7-2.31.51.61.81.81.51.51.61.6-1.61.61.6-1.61.61.7-1.6-1.61.2
K content in liver0.20.21.7-0.2-1.0-0.21.3-0.4-0.4-0.2-0.1-0.3-0.30.1-0.30.3-0.4-0.30.3-0.3-0.40.30.20.2
Mg content in liver0.50.50.90.80.01.00.10.70.60.80.80.70.60.90.7-0.70.60.7-0.70.70.6-0.7-0.80.9
Mn content in liver0.80.82.10.9-0.21.50.51.00.71.10.51.01.11.00.9-0.90.80.9-0.80.90.8-0.8-0.91.2
Na content in liver0.20.21.00.1-0.60.50.9-0.2-0.00.70.30.10.21.00.0-0.0-0.10.00.10.0-0.1-0.0-0.10.7
Rb content in liver0.30.31.1-0.3-0.4-1.10.2-0.4-0.6-1.0-0.5-0.5-0.5-0.9-0.50.5-0.5-0.50.5-0.5-0.50.50.4-0.1
Se content in liver0.10.20.6-0.4-0.7-0.10.6-0.1-0.3-0.2-0.6-0.3-0.3-0.6-0.30.3-0.2-0.30.2-0.3-0.10.20.3-0.8
Sr content in liver0.80.71.10.90.50.7-0.61.01.00.70.50.90.90.41.0-0.91.01.0-1.00.91.0-0.9-0.90.4
Zn content in liver1.82.02.7-1.2-1.5-1.61.3-1.4-1.4-1.5-1.0-1.6-1.6-1.2-1.51.5-1.4-1.51.4-1.5-1.31.41.4-1.6
Bone: minimum diameter0.10.20.30.50.40.6-0.30.60.50.50.40.50.50.30.4-0.50.50.5-0.50.50.5-0.5-0.50.5
Time in familiar zone, hab. session 10.40.30.90.50.30.9-0.30.80.20.80.60.70.80.70.5-0.50.50.5-0.50.50.4-0.4-0.50.8
Time in novel zone, hab. session 10.20.20.6-0.4-0.2-0.80.3-0.7-0.2-0.6-0.7-0.6-0.6-0.4-0.50.5-0.4-0.40.4-0.5-0.40.40.4-0.5
Total zone transitions, hab. session 10.81.11.41.11.10.6-0.91.21.00.91.01.00.90.91.1-1.11.11.1-1.11.11.0-1.1-1.10.8
Total locomotion distance, hab. session 11.01.42.51.31.60.5-1.61.21.41.01.31.11.00.91.2-1.21.31.3-1.31.21.3-1.3-1.20.5
Locomotion velocity, hab. session 11.21.72.81.41.70.6-1.71.41.51.01.41.21.01.01.4-1.41.41.4-1.41.41.4-1.4-1.30.6
Time in familiar zone, hab. session 21.11.12.41.10.41.3-0.10.91.01.20.91.31.41.21.1-1.10.90.9-0.91.00.9-1.0-1.11.5
Time in novel zone, hab. session 24.44.45.3-2.3-1.7-2.01.5-2.1-2.2-2.0-2.2-2.3-2.3-2.0-2.22.2-2.2-2.22.2-2.2-2.12.22.2-2.0
Total zone transitions, hab. session 22.02.54.81.72.11.3-2.21.71.71.41.21.41.31.21.6-1.61.71.7-1.71.61.6-1.7-1.61.0
Total locomotion distance, hab. session 21.11.43.91.31.70.4-2.01.31.30.71.11.00.90.81.2-1.21.31.3-1.31.21.3-1.3-1.20.4
Locomotion velocity, hab. session 21.01.44.51.21.80.4-2.11.21.30.71.00.90.80.61.1-1.11.31.2-1.31.21.3-1.2-1.10.2
Novel to familiar place preference ratio1.82.03.7-1.6-1.5-1.01.9-1.5-1.5-1.1-1.3-1.2-1.1-1.2-1.41.4-1.6-1.51.6-1.5-1.61.61.5-0.7
Novelty place preference2.93.15.4-1.9-1.9-1.32.3-1.9-1.9-1.4-1.7-1.5-1.4-1.5-1.81.8-1.9-1.91.9-1.8-2.01.91.8-1.0
Time in novel zone, NPP test2.72.95.5-1.8-1.9-1.32.3-1.8-1.8-1.3-1.6-1.5-1.3-1.4-1.71.7-1.8-1.81.9-1.7-1.91.81.7-0.9
Total zone transitions, NPP test1.72.54.81.62.01.3-2.21.71.61.41.61.41.31.21.6-1.61.61.6-1.61.61.6-1.6-1.50.9
Total locomotion distance, NPP test0.91.35.01.11.80.6-2.21.21.20.81.00.80.60.61.0-1.01.21.1-1.21.11.2-1.1-1.0-0.0
Locomotion velocity, NPP test0.81.15.11.01.80.5-2.31.11.10.70.90.70.50.50.9-0.91.11.0-1.11.01.1-1.1-0.9-0.2
Intraocular pressure0.60.82.2-0.80.0-0.9-0.1-0.6-0.4-1.1-0.9-0.9-0.9-1.3-0.90.9-0.8-0.90.8-1.0-0.80.91.0-1.5
Delta distance traveled before/after self-admin0.40.41.4-0.5-0.8-0.71.2-0.4-0.8-0.5-0.5-0.6-0.5-0.4-0.60.6-0.7-0.60.7-0.6-0.80.60.6-0.1
Delta ambulatory time before/after self-admin0.70.82.3-0.7-1.4-1.11.5-0.9-1.1-0.9-0.7-0.9-0.9-0.5-0.90.8-0.9-0.80.9-0.8-1.00.80.70.0
Parametrial fat weight7.116.620.14.34.14.3-3.84.53.84.44.24.04.04.14.1-4.14.14.1-4.14.14.1-4.0-4.13.4
Pavlov. Cond. lever latency0.10.20.80.3-0.40.30.60.40.10.40.60.40.50.60.3-0.30.20.2-0.20.30.2-0.2-0.40.9
Pavlov. Cond. magazine entry latency0.81.13.1-1.1-0.7-0.80.4-1.0-0.7-1.2-1.1-1.2-1.4-1.6-1.01.0-0.8-0.90.8-0.9-0.70.81.0-1.8
Pavlov. Cond. change in total contacts1.01.01.7-1.2-0.7-0.70.6-1.1-1.0-0.9-1.2-1.0-1.0-1.3-1.01.0-0.9-1.00.9-1.0-1.01.01.0-1.3
Pavlov. Cond. index score0.70.82.9-0.9-0.3-0.80.0-0.9-0.5-1.1-1.1-1.0-1.2-1.4-0.80.8-0.6-0.70.6-0.8-0.60.70.9-1.7
Pavlov. Cond. latency score0.50.62.5-0.8-0.2-0.7-0.1-0.8-0.4-1.0-1.0-0.9-1.1-1.3-0.70.7-0.5-0.60.5-0.7-0.50.60.7-1.6
Pavlov. Cond. lever contacts0.70.82.0-0.9-0.2-0.9-0.1-0.9-0.7-1.0-1.2-1.0-1.1-1.2-0.80.9-0.8-0.80.8-0.9-0.70.80.9-1.4
Pavlov. Cond. magazine entry number0.91.12.91.20.90.9-0.71.10.81.21.11.21.41.41.0-1.00.90.9-0.81.00.8-0.9-1.01.7
Pavlov. Cond. intertrial magazine entries0.20.20.40.4-0.4-0.00.40.40.40.40.60.50.50.50.4-0.50.50.4-0.40.50.5-0.5-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.70.92.9-1.0-0.3-0.90.1-1.0-0.5-1.1-1.1-1.0-1.2-1.4-0.80.8-0.7-0.70.7-0.8-0.70.70.9-1.7
Pavlov. Cond. response bias0.50.61.9-0.8-0.3-0.70.1-0.8-0.5-0.9-0.9-0.9-1.0-1.1-0.70.7-0.6-0.60.5-0.7-0.50.60.7-1.4
Pavlov. Cond. lever latency1.52.03.21.61.11.4-0.61.31.31.41.61.61.61.61.4-1.41.31.4-1.31.41.3-1.4-1.51.8
Pavlov. Cond. magazine entry latency3.84.65.8-2.3-1.8-2.21.6-2.1-2.0-2.3-2.3-2.2-2.2-2.4-2.12.1-2.1-2.12.1-2.2-2.02.12.2-2.3
Pavlov. Cond. change in total contacts2.13.46.6-2.1-1.2-1.70.6-1.6-1.7-1.7-2.1-2.0-2.0-2.3-1.81.9-1.7-1.81.7-1.9-1.61.81.9-2.6
Pavlov. Cond. index score3.75.06.6-2.5-1.8-2.21.3-2.1-2.1-2.3-2.4-2.4-2.4-2.6-2.32.3-2.1-2.22.1-2.3-2.12.22.3-2.6
Pavlov. Cond. latency score3.74.96.4-2.4-1.7-2.21.4-2.1-2.1-2.3-2.4-2.3-2.4-2.5-2.22.2-2.2-2.22.1-2.3-2.12.22.3-2.5
Pavlov. Cond. lever contacts1.92.64.7-1.8-1.2-1.70.6-1.4-1.5-1.7-1.8-1.8-1.9-1.9-1.61.6-1.5-1.51.5-1.6-1.41.61.7-2.2
Pavlov. Cond. magazine entry number5.87.28.72.92.32.6-2.12.72.62.82.92.72.73.02.7-2.72.62.7-2.62.72.6-2.7-2.72.8
Pavlov. Cond. intertrial magazine entries4.36.57.72.82.42.3-2.22.82.72.62.72.52.42.42.6-2.62.72.6-2.72.62.7-2.7-2.61.9
Pavlov. Cond. lever-magazine prob. diff.4.25.57.0-2.6-2.0-2.31.6-2.3-2.2-2.4-2.5-2.5-2.5-2.7-2.42.4-2.3-2.32.3-2.4-2.22.32.4-2.6
Pavlov. Cond. response bias3.44.66.9-2.4-1.7-2.11.2-2.0-1.9-2.2-2.4-2.3-2.4-2.5-2.22.2-2.0-2.12.0-2.2-2.02.12.2-2.6
Time in closed arm before self-admin3.74.89.02.62.92.1-3.02.61.92.22.71.91.92.02.0-2.02.02.0-2.02.01.9-1.9-1.91.6
Time in closed arm after self-admin3.33.64.92.22.12.0-1.61.71.82.02.02.02.01.92.0-1.91.91.9-1.91.91.8-1.8-1.81.4
Time in open arm before self-admin2.32.64.1-2.0-1.7-1.61.1-1.9-1.3-1.8-1.8-1.7-1.8-1.9-1.51.5-1.3-1.41.3-1.5-1.21.41.5-2.0
Time in open arm after self-admin0.80.91.7-1.3-1.2-0.90.7-1.1-0.7-0.8-1.2-0.8-0.8-0.7-0.90.9-0.9-1.00.9-1.0-0.80.91.0-0.7
Bone: periosteal estimation0.20.40.60.60.50.6-0.40.80.70.60.60.60.50.30.6-0.60.70.7-0.70.60.8-0.7-0.60.2
Bone: periosteal perimeter0.61.02.31.01.30.7-1.51.21.20.71.00.90.80.51.0-1.01.11.0-1.11.01.2-1.1-1.00.4
Bone: post-yield work0.60.92.01.00.60.8-0.20.81.00.91.01.11.21.01.0-1.00.90.9-0.91.00.8-0.9-1.01.4
Progressive ratio test 1 active lever presses3.13.86.0-2.1-2.4-2.42.1-2.0-2.0-2.3-1.4-2.0-2.1-2.1-1.91.8-1.8-1.81.8-1.7-1.81.71.6-1.4
Progressive ratio test 1 breakpoint2.73.45.3-1.9-2.3-2.32.0-1.9-1.9-2.2-1.3-1.9-2.0-2.0-1.81.7-1.7-1.71.7-1.6-1.71.61.5-1.4
Progressive ratio test 1 inactive lever presses0.10.21.7-0.1-1.1-0.41.3-0.4-0.4-0.20.1-0.1-0.10.0-0.20.1-0.2-0.10.2-0.1-0.30.1-0.00.4
Progressive ratio test 2 active lever presses2.02.45.0-1.5-2.2-2.11.9-1.7-1.9-1.8-0.7-1.7-1.7-1.3-1.51.4-1.5-1.41.4-1.2-1.51.21.1-0.4
Progressive ratio test 2 breakpoint2.22.55.1-1.6-2.3-2.11.9-1.8-1.9-1.8-0.8-1.7-1.7-1.3-1.61.4-1.5-1.41.5-1.3-1.51.31.1-0.4
Progressive ratio test 2 inactive lever presses0.10.20.8-0.2-0.8-0.50.9-0.4-0.5-0.30.0-0.1-0.00.0-0.20.2-0.3-0.30.3-0.2-0.40.30.10.7
Incentive Sensitization - Responses0.50.71.6-0.7-1.1-1.30.9-0.9-1.3-1.0-0.1-1.0-1.0-0.5-0.90.7-0.8-0.70.8-0.6-0.80.60.50.1
Incentive Sensitization - Breakpoint0.70.81.9-0.8-1.2-1.41.0-1.0-1.4-1.1-0.2-1.1-1.1-0.6-0.90.8-0.9-0.80.9-0.7-0.90.70.50.1
Sum of active levers in priming session hrs 5-60.30.30.7-0.5-0.5-0.60.4-0.6-0.3-0.6-0.8-0.3-0.3-0.5-0.50.5-0.5-0.60.6-0.6-0.60.60.6-0.3
Progressive ratio0.20.31.9-0.40.9-0.0-0.9-0.30.4-0.3-1.1-0.0-0.0-0.9-0.10.2-0.0-0.20.1-0.4-0.00.30.5-1.4
Food seeking constrained by brief footshock1.82.23.9-1.7-0.8-1.40.4-1.6-1.4-1.5-2.0-1.6-1.6-1.4-1.51.5-1.4-1.41.4-1.5-1.41.51.6-1.9
Seeking ratio, punishment vs. effort0.50.72.0-0.8-1.4-0.81.1-0.8-1.1-0.7-0.4-0.9-1.0-0.2-0.90.8-0.9-0.80.9-0.7-0.90.80.7-0.1
Retroperitoneal fat weight6.427.230.75.44.35.4-3.75.45.25.55.45.55.55.15.4-5.45.35.3-5.35.45.3-5.3-5.34.6
Reaction time number correct0.91.72.2-1.0-1.2-1.41.0-1.2-1.5-1.5-0.6-1.5-1.5-1.2-1.41.4-1.4-1.41.4-1.3-1.41.31.3-0.8
Reaction time mean minus median0.71.83.6-1.2-0.4-1.70.9-1.4-0.9-1.6-1.9-1.2-1.1-1.7-1.21.3-1.2-1.31.2-1.4-1.21.41.4-1.6
Reaction time mean minus median AUC0.61.52.9-1.0-0.0-1.60.5-1.2-0.7-1.6-1.7-1.1-1.1-1.7-1.11.2-1.1-1.21.1-1.3-1.01.21.4-1.6
Reaction time num false alarms0.10.10.3-0.3-0.6-0.40.4-0.3-0.4-0.5-0.2-0.2-0.2-0.1-0.30.3-0.4-0.30.4-0.3-0.40.40.30.3
Reaction time num false alarms AUC0.00.00.40.1-0.2-0.10.00.10.0-0.20.30.10.10.30.1-0.10.10.1-0.10.20.0-0.1-0.20.6
Reaction time trials correct on left0.91.72.2-1.0-1.2-1.41.0-1.2-1.5-1.5-0.6-1.5-1.5-1.2-1.41.4-1.4-1.41.4-1.3-1.41.31.3-0.8
Reaction time trials on left0.91.72.4-1.1-1.2-1.41.0-1.2-1.5-1.5-0.7-1.5-1.5-1.3-1.51.4-1.4-1.41.4-1.4-1.41.31.3-0.9
Reaction time mean0.10.21.1-0.31.0-0.3-0.7-0.30.1-0.3-0.80.00.1-0.5-0.20.3-0.3-0.40.3-0.5-0.30.50.6-0.7
Reaction time mean AUC0.20.40.9-0.50.9-0.5-0.5-0.5-0.2-0.5-1.0-0.2-0.1-0.7-0.40.6-0.6-0.70.6-0.7-0.60.80.9-0.7
Median of all reaction times0.10.21.70.11.30.3-1.10.10.40.2-0.30.40.50.00.2-0.00.1-0.0-0.0-0.10.10.20.2-0.2
Reaction time omissions0.00.10.3-0.10.00.10.20.10.2-0.10.1-0.1-0.2-0.50.1-0.20.30.3-0.30.20.4-0.3-0.3-0.5
Reaction time false alarm rate0.40.51.10.60.30.6-0.50.70.70.50.60.80.80.90.8-0.80.70.8-0.70.80.7-0.7-0.81.0
Reaction time premature initiation rate1.42.03.5-1.6-1.0-1.21.0-1.3-1.3-1.3-1.8-1.5-1.4-1.6-1.41.4-1.3-1.41.3-1.5-1.31.41.5-1.9
Reaction time premature initiations2.44.25.1-2.1-1.6-1.91.4-2.0-2.2-2.0-2.1-2.2-2.2-2.2-2.12.1-2.1-2.12.1-2.1-2.02.12.1-2.3
Std. dev. reaction times0.30.51.2-0.50.6-0.8-0.3-0.7-0.4-0.8-1.1-0.5-0.3-0.8-0.50.7-0.6-0.70.6-0.8-0.50.80.8-0.8
Reaction time trials completed0.91.72.4-1.1-1.2-1.41.0-1.2-1.5-1.5-0.7-1.5-1.5-1.3-1.51.4-1.4-1.41.4-1.4-1.41.31.3-0.9
Reaction time trials AUC0.91.82.4-1.1-1.2-1.31.0-1.3-1.5-1.5-0.7-1.5-1.6-1.3-1.51.4-1.4-1.41.4-1.4-1.41.41.3-0.9
Run reversals in cocaine runway, females1.91.93.11.61.21.3-1.81.61.21.61.71.21.11.61.3-1.31.31.4-1.41.41.4-1.4-1.40.9
Run reversals in cocaine runway, males0.40.40.90.50.50.6-0.90.90.50.80.80.30.20.50.6-0.70.70.8-0.80.80.8-0.8-0.80.0
Latency to leave start box in cocaine runway0.10.10.3-0.10.3-0.0-0.10.1-0.4-0.1-0.1-0.3-0.2-0.0-0.40.5-0.5-0.50.6-0.5-0.60.60.5-0.1
Latency to leave start box in cocaine runway, F0.81.01.8-0.9-1.3-0.81.4-0.9-1.3-0.7-0.7-0.9-0.7-0.3-1.01.0-1.2-1.11.2-1.0-1.21.10.90.2
Latency to leave start box in cocaine runway, M1.41.36.31.32.51.2-2.31.71.31.00.61.01.00.50.9-0.80.90.8-0.80.60.9-0.6-0.5-0.2
Std. dev. time between licks in bursts1.72.33.31.61.51.2-1.71.61.81.51.51.51.31.31.5-1.51.61.6-1.61.51.7-1.6-1.50.7
Total sessions with >9 infusions1.51.94.2-1.5-2.0-1.81.7-1.5-1.6-1.6-0.8-1.4-1.5-1.4-1.41.2-1.2-1.21.2-1.1-1.21.11.0-0.7
Short access day 1 total inactive lever presses0.00.00.40.2-0.1-0.10.30.1-0.20.10.10.20.30.20.1-0.10.10.1-0.00.10.1-0.1-0.20.6
Short access day 10 total inactive lever presses0.10.30.60.70.10.60.20.60.50.60.40.60.60.70.6-0.50.50.5-0.50.50.5-0.5-0.50.6
Short access day 1 total infusions0.40.51.7-0.6-1.3-1.21.1-0.8-1.0-0.9-0.0-0.7-0.7-0.4-0.60.4-0.5-0.40.5-0.3-0.50.30.20.2
Short access day 10 total infusions0.30.41.3-0.4-1.0-1.11.0-0.6-1.0-1.00.1-0.5-0.5-0.5-0.50.4-0.5-0.40.5-0.3-0.50.30.20.4
Short access total infusions1.82.24.4-1.6-2.1-2.02.0-1.6-1.9-1.9-0.9-1.5-1.5-1.4-1.51.3-1.4-1.31.4-1.2-1.41.21.0-0.5
Short access day 1 locomotion0.20.20.6-0.6-0.7-0.80.3-0.7-0.7-0.5-0.2-0.7-0.8-0.4-0.50.4-0.4-0.30.3-0.3-0.30.20.2-0.1
Short access day 10 total locomotion1.73.17.11.90.91.7-0.41.61.61.71.92.12.21.81.8-1.81.71.7-1.61.81.6-1.7-1.82.7
Short access total locomotion0.50.62.80.70.20.40.20.50.40.60.90.90.90.70.7-0.70.60.6-0.60.70.6-0.7-0.81.7
One hour access (0.3 mA shock)1.01.12.7-0.9-1.3-1.61.2-1.1-1.4-1.5-0.5-1.2-1.2-1.0-1.10.9-1.0-0.91.0-0.8-1.00.90.7-0.3
Compulsive drug intake0.10.10.60.20.70.5-0.80.20.50.5-0.10.20.20.20.3-0.30.40.3-0.40.20.4-0.3-0.2-0.3
One hour access (shock baseline)0.81.23.1-0.8-1.4-1.81.3-1.0-1.6-1.5-0.2-1.1-1.1-0.8-1.10.9-1.1-1.01.1-0.8-1.10.90.70.1
Social response proportion0.80.93.2-0.7-1.8-1.41.7-1.0-1.0-1.1-0.6-0.7-0.8-0.6-0.80.7-0.8-0.70.7-0.6-0.80.60.50.0
Social responses0.10.10.90.1-1.0-0.60.8-0.3-0.1-0.4-0.2-0.1-0.2-0.0-0.10.0-0.0-0.00.00.00.0-0.0-0.10.1
Social time0.10.10.60.2-0.8-0.80.6-0.2-0.4-0.50.3-0.1-0.10.0-0.10.1-0.1-0.10.1-0.0-0.10.0-0.00.3
Soleus weight0.20.51.40.60.51.2-0.30.60.70.90.40.70.70.60.7-0.70.70.7-0.70.70.8-0.7-0.60.2
Bone: stiffness3.76.08.0-2.5-2.1-2.82.1-2.4-2.2-2.7-2.7-2.4-2.5-2.8-2.42.4-2.3-2.32.3-2.4-2.22.42.4-2.7
Tibialis anterior weight0.31.13.5-0.8-0.1-1.0-0.0-1.0-0.7-1.4-1.1-1.3-1.4-1.5-1.01.0-0.8-0.90.8-1.0-0.80.91.1-1.9
Time to tail flick, vehicle, before self-admin0.50.51.0-0.7-0.9-1.00.8-1.0-0.9-0.8-0.4-0.8-0.8-0.6-0.70.6-0.7-0.60.7-0.6-0.70.60.5-0.2
Time to tail flick, vehicle, after self-admin1.11.53.71.60.90.8-0.51.20.90.81.91.11.11.21.1-1.21.11.2-1.11.31.1-1.3-1.41.6
Time to tail flick, test, before self-admin3.13.24.32.01.91.5-2.01.91.51.52.11.61.61.61.8-1.91.91.9-1.91.91.8-1.9-1.91.6
Time to tail flick, test, after self-admin0.10.20.80.3-0.60.00.90.5-0.1-0.00.50.20.2-0.00.3-0.40.30.4-0.40.40.4-0.4-0.50.1
Delta time to tail flick, vehicle, before/after SA1.21.12.51.50.90.8-0.61.60.80.61.50.90.90.91.0-1.11.01.0-1.01.11.1-1.1-1.21.0
Delta time to tail flick, test, before/after SA1.51.53.4-1.4-1.8-1.01.8-1.2-1.1-1.1-1.3-1.1-1.2-1.3-1.21.1-1.1-1.11.1-1.1-1.01.01.1-1.4
Tibia length0.10.21.1-0.20.7-0.2-1.00.1-0.3-0.3-0.3-0.4-0.4-0.5-0.20.2-0.2-0.20.2-0.2-0.10.20.3-0.6
Ambulatory time before self-admin0.81.23.10.81.21.7-1.10.91.51.60.71.31.30.71.1-1.01.11.0-1.10.91.2-0.9-0.7-0.4
Ambulatory time after self-admin0.30.31.20.1-0.11.10.4-0.10.71.10.30.70.60.40.6-0.50.60.5-0.60.50.6-0.5-0.4-0.1
Bone: tissue strength0.40.42.7-0.5-1.30.31.6-0.5-0.70.3-0.2-0.00.20.3-0.30.3-0.5-0.40.5-0.3-0.60.40.20.8
Total heroin consumption0.91.01.5-0.8-0.7-1.21.0-1.1-1.1-1.0-0.8-1.0-0.9-0.7-1.11.1-1.1-1.11.2-1.1-1.21.11.1-0.4
Bone: trabecular number0.30.61.20.71.10.8-1.10.80.70.80.50.80.80.60.7-0.70.70.7-0.70.70.7-0.6-0.60.6
Bone: trabecular spacing0.10.10.30.50.00.20.00.40.20.20.60.10.10.30.2-0.20.20.3-0.30.30.3-0.3-0.30.2
Bone: trabecular thickness0.50.71.4-1.00.1-0.8-0.3-0.8-0.8-0.9-1.2-0.8-0.8-1.0-0.80.8-0.7-0.80.8-0.9-0.70.80.9-1.0
Bone: trabecular tissue density0.71.01.3-1.1-0.9-1.11.0-1.1-1.0-1.0-1.0-0.9-0.9-0.9-1.01.0-1.0-1.01.0-1.0-1.01.01.0-0.7
Water consumed over 24 hours0.20.20.40.4-0.10.10.20.50.60.40.40.40.30.30.6-0.60.60.6-0.70.60.6-0.6-0.60.2
Number of responses in last shaping day0.80.92.2-1.0-0.4-0.90.2-1.0-0.7-0.7-1.1-0.8-0.8-1.0-0.91.0-0.9-1.00.9-1.1-0.91.11.2-1.5